Oral components

Abstract

The present invention provides an oral composition that exhibits excellent anti-inflammatory effects and is effective in preventing or suppressing oral diseases such as dental caries and periodontal disease. [Solution] An oral composition containing glycyrrhizinate.

Description

Technical Field

[0001] The present invention relates to an oral composition having an excellent anti-inflammatory effect and being effective for preventing or suppressing oral diseases such as dental caries and periodontal diseases.

Background Art

[0002] imparting an anti-inflammatory effect to an oral composition is effective for preventing or suppressing oral diseases such as dental caries and periodontal diseases. Therefore, the development of an oral composition having an excellent anti-inflammatory effect is desired.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0004] The present invention has been made in view of the above circumstances, and an object thereof is to provide an oral composition having an excellent anti-inflammatory effect.

Means for Solving the Problems

[0005] As a result of intensive studies to achieve the above object, the present inventors have found that an oral composition containing glycyrrhetinate and further preferably containing one or more selected from surfactants, abrasives, thickeners, wetting agents, solvents, sweeteners, flavors, cooling agents, pH adjusters, preservatives, coloring agents, suspending agents, functional components and flavoring components has an excellent anti-inflammatory effect, and thus has completed the present invention.

[0006] Therefore, the present invention provides the following oral compositions. 〔1〕 An oral composition containing glycyrrhetinate. 〔2〕 The oral composition according to [1] further contains one or more selected from surfactants, abrasives, thickeners, humectants, solvents, sweeteners, fragrances, cooling agents, pH adjusters, preservatives, colorants, suspending agents, functional ingredients, and flavoring ingredients. [3] The oral composition according to [2], wherein the surfactant is one or more selected from the anionic surfactants, nonionic surfactants and amphoteric surfactants shown in (i) to (iii) below. (i) Anionic surfactant selected from alkyl sulfates, acyl sarcosine salts, acyl methyl taurate salts, acyl glutamate salts, and α-olefin sulfonates. (ii) Nonionic surfactant selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, and fatty acid monoglycerides. (iii) an amphoteric surfactant selected from fatty acid amidopropyl betaine and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt [4] The oral composition according to [2] or [3], wherein the abrasive is one or more selected from anhydrous silicic acid, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide. [5] An oral composition according to any one of [2] to [4], wherein the thickening agent is one or more selected from xanthan gum, sodium alginate, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, carboxyvinyl polymer, and thickening silica. [6] An oral composition according to any one of [2] to [5], wherein the humectant is one or more selected from sorbitol, xylitol, erythritol, glycerin, propylene glycol, and polyethylene glycol. [7] The oral composition according to any one of [2] to [6], wherein the solvent is one or two selected from purified water and ethanol. [8] An oral composition according to any one of [2] to [7], wherein the sweetener is one or more selected from saccharin, sodium saccharin, and sucralose. [9] The fragrances include peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, and pimentoium. Cinnamon oil, cinnamon leaf oil, perilla oil, menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, Caryophyllene, Germacrene, Viridiflorol, Methyl Cinnamate, Methylheptin Carbonate, Ionone, Ethyl-β-Methylthiopropionate, Cith-6-Nonenool, Carone, Methyl Jasmonate, Citronellyl Acetate, Ethyl Linalool, Ethyl Acetate, Ethyl Butyrate, Isoamyl Acetate, Hexanal, Hexenal, Methyl Anthranilate, Ethyl Methylphenyl Glycidate, Benzaldehyde, Vanillin, Ethyl Vanillin, Furaneol, Ethyl Cyclopentenolone, 3-Hydroxy-4 ,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalactone, decalactone, hexyl acetate, ethyl-2-methylbutyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol,The cooling agent is one or more selected from chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, and cardamom extract, and the cooling agent is N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-yl) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopuregol, menthyl glycol ketal, N-(4-cyanomethyl ethyl) Nyl)-p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2- An oral composition according to any one of [2] to [8], comprising one or more selected from diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopuregol.

[10] An oral composition according to any one of [2] to [9], wherein the pH adjusting agent is one or more selected from citric acid, citrate, tartaric acid, tartarate, succinic acid, succinate, malic acid, malate, hydrochloric acid, sodium hydroxide, trisodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, and sodium bicarbonate.

[11] An oral composition according to any one of [2] to

[10] , wherein the preservative is one or two selected from parahydroxybenzoic acid esters and sodium benzoate.

[12] An oral composition according to any one of [2] to

[11] , wherein the coloring agent is one or more selected from Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium dioxide, and titanium mica.

[13] The oral composition according to any one of [2] to

[12] , wherein the suspending agent is one or more selected from olive oil, camellia oil, castor oil, and triglycerides having 6 to 12 carbon atoms in the fatty acid.

[14] An oral composition according to any one of [2] to

[13] , wherein the functional ingredient is one or more selected from sodium fluoride, sodium monofluorophosphate, stannous fluoride, dextranase, sodium pyrrolidone carboxylate, tranexamic acid, epsilon-aminocaproic acid, allantoin, glycyrrhetinate, sodium chloride, vitamin E, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, Phellodendron amurense bark extract, sodium lauroyl glutamate, sodium tetradecenesulfonate, sodium polyglutamate, cationized cellulose, propylene glycol alginate, and l-menthol.

[15] The flavoring component is one or more selected from alanine, glycine, potassium aluminum sulfate, and sodium sulfate, and the oral composition according to any one of [2] to

[14] . 〔16〕 The oral composition according to any one of [1] to

[15] , having a pH of 5 to 9. 〔17〕 The oral composition according to any one of [1] to

[16] , which is in a paste or gel form with a viscosity at 25 °C measured by a BH viscometer of 40 to 150 Pa·s. 〔18〕 The oral composition according to any one of [1] to

[16] , which is in a liquid form with a viscosity at 25 °C measured by a BH viscometer of 30 mPa·s or less. 〔19〕 The oral composition according to any one of [1] to

[18] , which is a dentifrice, mouthwash, coating agent, sheet agent, or spray agent.

Advantages of the Invention

[0007] According to the present invention, an oral composition excellent in anti-inflammatory effect and widely usable for the prevention or suppression of oral diseases such as dental caries and periodontal disease can be provided.

Embodiments for Carrying Out the Invention

[0008] Hereinafter, the present invention will be described in more detail. The oral composition of the present invention is characterized by containing glycyrrhetinate.

[0009] Glycyrrhetinate has an anti-inflammatory action, and in the oral cavity, it is known to have an effect of controlling the oral flora, an effect of improving the oral flora, an effect of suppressing periodontal disease-causing bacteria, an effect of suppressing oral pathogenic bacteria, an effect of suppressing the growth of periodontal disease-causing bacteria, an effect of maintaining the growth of oral resident bacteria (e.g., nitrate-reducing bacteria), an effect of controlling the balance of the oral flora, and an antibacterial effect. Examples of the salt include dipotassium glycyrrhetinate. As the glycyrrhetinate, commercially available products such as dipotassium glycyrrhetinate manufactured by Maruzen Pharmaceutical Co., Ltd. can be used.

[0010] The blending amount of glycyrrhizinate is preferably 0.005% or more (mass%, the same applies hereinafter) of the whole composition, more preferably 0.01% or more. Also, it is preferably 1% or less, more preferably 0.50% or less. When the blending amount is 0.005% or more, a good anti-inflammatory effect can be obtained.

[0011] The oral composition of the present invention can be prepared and used in the form of paste, gel, liquid, solid, etc., in dosage forms such as dentifrices, gel dentifrices, liquid dentifrices, wet dentifrices, mouthwashes, coating agents, sheet agents, spray agents (mouthwash), etc. The preparation method can adopt a conventional method according to the form and dosage form. In this case, according to the purpose, dosage form, etc. of the oral composition, other optional components can be appropriately blended as necessary in addition to the above-described components. Optional components include various components known for oral use, for example, surfactants, abrasives, thickeners, wetting agents, solvents, sweeteners, fragrances, cooling agents, pH adjusters, preservatives, coloring agents, suspending agents, functional components, flavoring components, etc. Note that it can also be prepared into an oral composition without an abrasive, and generally, an abrasive is not blended in a liquid oral composition such as a mouthwash.

[0012] Specific examples of the optional components are shown below. These optional components can be blended singly or in combination of two or more, and the blending amount of each optional component can be a normal amount within a range that does not interfere with the effects of the present invention.

[0013] Surfactant: Surfactants include anionic surfactants, nonionic surfactants, and amphoteric surfactants, specifically shown in the following (i) to (iii). (i) Anionic surfactant Alkyl sulfates such as lauryl sulfate, acyl sarcosinate, acyl methyl taurinate, acyl glutamate, α-olefin sulfonate (tetradecene sulfonate) As the above salts, alkali metal salts, particularly sodium salts and potassium salts, are preferred. (ii) Nonionic surfactant Polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, fatty acid monoglyceride (iii) Amphoteric surfactants Fatty acid amidopropyl betaines such as coconut oil fatty acid amidopropyl betaine, N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts The amount of surfactant should be 0.001 to 10% of the total composition, preferably 0.1 to 5%.

[0014] Abrasives: Examples include silica-based abrasives such as anhydrous silicic acid, zeolites, calcium carbonate, aluminum hydroxide, and aluminum oxide. The amount of abrasive material is typically 2-50% of the total composition, and especially 10-40%.

[0015] Thickener: Examples of organic thickeners include xanthan gum, sodium alginate, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, and carboxyvinyl polymer, as well as inorganic thickeners such as thickening silica. The amount of thickener added is typically 0.1-10% of the total composition, and especially 0.1-8%.

[0016] Humectants: Examples include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol (PEG). The amount of wetting agent is typically between 2% and 50% of the total composition.

[0017] solvent: Examples include purified water and lower monohydric alcohols having 2 or 3 carbon atoms, such as ethanol. Sweeteners: Examples include saccharin, sodium saccharin, and sucralose.

[0018] Fragrance:Natural essential oils known for oral use, such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, etc.; menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl Fragrance components contained in the above natural essential oils, such as salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, caryophyllene, germacrene, viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, ethyl linalool, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalactone, decalactone, hexyl acetate, ethyl-2- Examples of fragrance components include methyl butyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, and ethyl maltol; plant extracts such as chili pepper extract, ginger extract, pepper extract, and Japanese pepper extract; cardamom extract; and various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils.

[0019] The amount of fragrance is 0.0000001 to 5.0% of the total composition, preferably 0.000010 to 3.0%, and more preferably 0.010 to 2.0%. A solvent may also be used when compounding these fragrances. Examples of solvents include ethanol, propylene glycol, glycerin fatty acid ester, and triacetin.

[0020] Cooling agent: Cooling agents known for oral use, for example, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopuregol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthane Examples include tancarboxamide, 3-l-mentoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophene-2-ylmethyl)acetamide, and isopuregol.

[0021] The amount of cooling agent included is preferably 0.00001 to 0.01% of the total composition, but it may also be omitted or at 0%.

[0022] pH adjuster: Examples include organic acids such as citric acid, citrates, tartaric acid, tartarates, succinic acid, succinates, malic acid, malates, or their salts, hydrochloric acid, sodium hydroxide, trisodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, and sodium bicarbonate.

[0023] Preservatives: Examples include parahydroxybenzoic acid esters and sodium benzoate. Coloring agents: Examples include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, and titanium mica. Suspension: Examples include olive oil, camellia oil, castor oil, triglycerides with 6 to 12 carbon atoms, and emulsions containing these oils.

[0024] Functional ingredients (active ingredients): Examples include fluorine-containing compounds such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; enzymes such as dextranase; sodium pyrrolidone carboxylate; tranexamic acid; epsilon-aminocaproic acid; allantoin; glycyrrhetinate; sodium chloride; vitamin E; isopropylmethylphenol; copper gluconate; cetylpyridinium chloride; benzalkonium chloride; benzethonium chloride; hinokitiol; pyrophosphate; polyphosphate; metaphosphate; zeolite; aluminum lactate; potassium nitrate; calcium glycerophosphate; Phellodendron amurense bark extract; sodium lauroyl glutamate; sodium tetradecenesulfonate; sodium polyglutamate; cationized cellulose; propylene glycol alginate; and l-menthol.

[0025] Flavoring ingredients: Examples include alanine, glycine, aluminum potassium sulfate, and sodium sulfate.

[0026] The oral composition of the present invention preferably has a pH of 5.0 to 9.0 at 25°C.

[0027] The oral composition of the present invention can be adjusted to an appropriate viscosity depending on its form and other factors. For oral compositions in paste or gel form, it is preferable that the viscosity at 25°C, as measured by a BH viscometer, is 40 to 150 Pa·s. For oral compositions in liquid form, it is preferable that the viscosity at 25°C, as measured by a BH viscometer, is 30 mPa·s or less, and particularly between 0.7 and 30 mPa·s.

[0028] Furthermore, oral compositions can be housed in general-purpose containers. The shape and material of the container are not particularly limited, and known containers used for oral compositions can be used. Specifically, examples include containers made of plastic materials such as polyethylene, polypropylene, polyethylene terephthalate, and nylon. The innermost layer of the container is preferably made of polyethylene (PE), and a container made of linear low-density polyethylene (LLDPE) is particularly preferred. [Examples]

[0029] The present invention will be specifically described below with reference to example formulations, but the present invention is not limited to the following examples. In the following examples, % all represent mass percentages unless otherwise specified. The amounts in the table refer to the quantities of the items listed.

[0030] The oral compositions shown in the following example formulations were prepared by the method described below and used in the usual manner, and all of them exhibited good anti-inflammatory effects. • Preparation Method 1 (Toothpaste: Prescription Examples 1-40) Purified water was mixed with water-soluble substances, inorganic thickeners, and organic thickeners. Then, fragrance, surfactant, and, if necessary, abrasives and oil-soluble components were added, and the mixture was further mixed under reduced pressure (4 kPa) to obtain a toothpaste composition. A 5L capacity kneader (manufactured by Ishiyama Kogyo Co., Ltd.) was used for the manufacturing process. • Preparation Method 2 (Liquid Composition: Formulation Examples 41-51) Glycyrrhizinate and other raw material components were sequentially added to a solvent such as purified water and stirred to dissolve uniformly and obtain a mouthwash composition. A 1L beaker and a three-one motor (BL1200, manufactured by HEIDON) were used for the preparation.

[0031] [Table 1]

[0032] [Table 2]

[0033] [Table 3]

[0034] [Table 4]

[0035] [Table 5]

[0036] [Table 6]

[0037] The ingredients in the above example formulation are as follows: *1; Dipotassium glycyrrhizinate: Maruzen Pharmaceutical Co., Ltd. Dipotassium glycyrrhizinate *2; Abrasive silica: Evonik Co., Ltd. Zeodent124 *3; Silica granules (average particle size 250 μm): Tosoh Silica Co., Ltd. NIPGEL AY-001 *4; Silica granules (average particle size 100 μm): Tosoh Silica Co., Ltd. NIPGEL AY-002 *5; Thickening silica: DSL Japan Co., Ltd. Carplex #67Q (Absorption capacity: 2.1~2.7 mL / g) *6; Thickening silica: Aerosil 200, Nippon Aerosil Co., Ltd. (Liquid absorption capacity: 4.2) *7; Xanthan gum: CP Kelco Monart Gum DA (viscosity: 1300~1700 mPa·s) *8; Sodium carboxymethylcellulose: Nippon Paper Industries Co., Ltd. Sunrose F08HC (viscosity: 60-100 mPa·s) *9; Sodium alginate: Kimika Co., Ltd. Kimika Algin (viscosity: 2500~3500 mPa·s) *10; Propylene glycol alginate: Kimika Co., Ltd. Kimiloid BF (viscosity: 50-165 mPa·s) *11; Sodium polyacrylate: Toagosei Co., Ltd. Rheogic 260H (viscosity: 7000~9500 mPa·s) *12; Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated.

[0038] Furthermore, in the above example formulation, the fragrance column may contain fragrances with the following compositions A to Y.

[0039] [Table 7]

[0040] [Table 8]

[0041] [Table 9]

[0042] [Table 10]

[0043] [Table 11]

[0044] Table 12

[0045] Table 13

[0046] Table 14

[0047] Table 15

[0048] Table 16

[0049] Table 17

[0050] Table 18

[0051] Table 19

[0052] Table 20

[0053] Table 21

[0054] Table 22

[0055] Table 23

[0056] Table 24

[0057] Table 25

[0058] Table 26

[0059] Table 27

[0060] Table 28

[0061] Table 29

[0062] Table 30

[0063] Table 31

Claims

1. An oral composition containing glycyrrhizinate.

2. The oral composition according to claim 1, further comprising one or more selected from surfactants, abrasives, thickeners, humectants, solvents, sweeteners, fragrances, cooling agents, pH adjusters, preservatives, colorants, suspending agents, functional components, and flavoring components.

3. The oral composition according to claim 2, wherein the surfactant is one or more selected from the anionic surfactants, nonionic surfactants, and amphoteric surfactants shown in (i) to (iii) below. (i) Anionic surfactant selected from alkyl sulfates, acyl sarcosine salts, acyl methyl taurate salts, acyl glutamate salts, and α-olefin sulfonate salts. (ii) Nonionic surfactant selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, and fatty acid monoglyceride. (iii) Amphoteric surfactant selected from fatty acid amidopropyl betaine and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salt

4. The oral composition according to claim 2, wherein the abrasive is one or more selected from anhydrous silicic acid, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide.

5. The oral composition according to claim 2, wherein the thickening agent is one or more selected from xanthan gum, sodium alginate, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, carboxyvinyl polymer, and thickening silica.

6. The oral composition according to claim 2, wherein the humectant is one or more selected from sorbitol, xylitol, erythritol, glycerin, propylene glycol, and polyethylene glycol.

7. The oral composition according to claim 2, wherein the solvent is one or two selected from purified water and ethanol.

8. The oral composition according to claim 2, wherein the sweetener is one or more selected from saccharin, sodium saccharin, and sucralose.

9. The fragrance contains peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, and pimentoium. Cinnamon oil, cinnamon leaf oil, perilla oil, menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, Caryophyllene, Germacrene, Viridiflorol, Methyl Cinnamate, Methylheptin Carbonate, Ionone, Ethyl-β-Methylthiopropionate, Cith-6-Nonenole, Carone, Methyl Jasmonate, Citronellyl Acetate, Ethyl Linalool, Ethyl Acetate, Ethyl Butyrate, Isoamyl Acetate, Hexanal, Hexenal, Methyl Anthranilate, Ethyl Methylphenyl Glycidate, Benzaldehyde, Vanillin, Ethyl Vanillin, Furaneol, Ethyl Cyclopentenolone, 3-Hydroxy-4 ,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalactone, decalactone, hexyl acetate, ethyl-2-methylbutyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol,The cooling agent is one or more selected from chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, and cardamom extract, and the cooling agent is N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, N-p-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopuregol, menthyl glycoside ketal, N-(4-cyano Methylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N, 2,3-trimethylbutylamide, N- The oral composition according to claim 2, comprising one or more selected from tyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide, and isopuregol.

10. The oral composition according to claim 2, wherein the pH adjusting agent is one or more selected from citric acid, citrate, tartaric acid, tartarate, succinic acid, succinate, malic acid, malate, hydrochloric acid, sodium hydroxide, trisodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, and sodium bicarbonate.

11. The oral composition according to claim 2, wherein the preservative is one or two selected from parahydroxybenzoic acid esters and sodium benzoate.

12. The oral composition according to claim 2, wherein the coloring agent is one or more selected from Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium dioxide, and titanium mica.

13. The oral composition according to claim 2, wherein the suspending agent is one or more selected from olive oil, camellia oil, castor oil, and triglycerides having 6 to 12 carbon atoms in the fatty acid.

14. The oral composition according to claim 2, wherein the functional ingredient is one or more selected from sodium fluoride, sodium monofluorophosphate, stannous fluoride, dextranase, sodium pyrrolidone carboxylate, tranexamic acid, epsilon-aminocaproic acid, allantoin, glycyrrhetinate, sodium chloride, vitamin E, isopropylmethylphenol, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, Phellodendron amurense bark extract, sodium lauroyl glutamate, sodium tetradecenesulfonate, sodium polyglutamate, cationized cellulose, propylene glycol alginate, and l-menthol.

15. The oral composition according to claim 2, wherein the flavoring component is one or more selected from alanine, glycine, aluminum potassium sulfate, and sodium sulfate.

16. The oral composition according to claim 1 or 2, wherein the pH is 5 to 9.

17. The oral composition according to claim 1 or 2, wherein the viscosity at 25°C, as measured by a BH viscometer, is 40 to 150 Pa·s and is in the form of a paste or gel.

18. The oral composition according to claim 1 or 2, wherein the viscosity at 25°C, as measured by a BH viscometer, is 30 mPa·s or less and is in a liquid state.

19. The oral composition according to claim 1 or 2, which is a toothpaste, mouthwash, ointment, sheet, or spray.

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