Oral components

Abstract

The present invention aims to provide an oral composition that can maintain the stability of an enzyme when an anionic surfactant and an enzyme are used in combination, and that exhibits good foaming and foam retention. [Solution] The present invention provides an oral composition comprising (A) an enzyme, (B) an anionic surfactant comprising (B-1) an alkyl sulfate and / or acylmethyl taurate salt and (B-2) one or more selected from the group consisting of α-oleiculfonate, acyl sarcosine salt, acyl glutamate, and sulfosuccinate, and (C) a glycyrrhizinate, wherein the content of component (B) is 0.3 to 1.3% by mass.

Description

Technical Field

[0001] The present invention relates to an oral composition.

Background Art

[0002] Conventionally, various enzymes have been incorporated into oral compositions from the viewpoints of preventing and suppressing the progression of dental caries, preventing halitosis, and further improving the aesthetics of teeth. As an enzyme that can be incorporated into an oral composition, for example, dextranase is known to provide a dental caries preventive effect by decomposing plaque.

[0003] On the other hand, surfactants are usually incorporated into oral compositions from the viewpoints of improving the feel and usability. Examples of surfactants incorporated into oral compositions include anionic surfactants incorporated from the viewpoint of ensuring sufficient foaming properties.

[0004] However, anionic surfactants may denature and inactivate enzymes. Therefore, when an enzyme such as dextranase is incorporated into an oral composition, a specific surfactant is incorporated together with or instead of the anionic surfactant from the viewpoint of ensuring the stabilization of the activity of dextranase. For example, Patent Document 1 describes incorporating an anionic surfactant and a carboxylic acid type amphoteric surfactant, Patent Document 2 describes incorporating polyoxyethylene alkyl ether, Patent Document 3 describes incorporating glycerin fatty acid ester, and Patent Document 4 describes incorporating fatty acid diethanolamide.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document 2

Patent Document 3

[0006] However, with the conventional technology described above, the expected foaming and foam retention due to the inclusion of anionic surfactants may not be achieved. In addition, the denaturation and inactivation of enzymes by anionic surfactants may not be sufficiently suppressed.

[0007] The present invention aims to provide an oral composition that can maintain the stability of an enzyme when an anionic surfactant and an enzyme are used in combination, and that exhibits good foaming and foam retention. [Means for solving the problem]

[0008] The present invention provides [1] to [9]. [1] Component (A) Enzyme Anionic surfactant containing components (B), (B-1), and (B-2). (B-1) Alkyl sulfates and / or acylmethyl taurine salts (B-2) One or more selected from the group consisting of α-oleisulfonates, acylsarcosine salts, acylglutamates, and sulfosuccinates. Ingredient (C) Glycyrrhizate Includes, The content of component (B) is 0.3 to 1.3% by mass. Oral composition. [2] The oral composition according to [1], wherein component (A) comprises one or both of glucanase and protease. [3] The oral composition according to [1], wherein component (A) comprises one or more selected from the group consisting of dextranase, mutanase, actinidine, papain, and bromelain. [4] Component (A) contains dextranase, The enzyme activity of dextranase is between 2 U / g and 200 U / g. The oral composition described in [3]. [5] Component (A) contains papain, The enzyme activity of papain is 400 U / g to 40,000 U / g. The oral composition described in [3]. [6] An oral composition according to any one of items [1] to [5], wherein the content of (B-1) is 0.1 to 0.8% by mass. [7] An oral composition according to any one of items [1] to [6], wherein the content of (B-2) is 0.1 to 0.8% by mass. [8] An oral composition according to any one of items [1] to [7], wherein the content of component (B) is 0.3 to 1.0% by mass. [9] An oral composition according to any one of items [1] to [8], wherein the ratio of the content of (B-2) to the content of (B-1) is 0.15 to 4. [Effects of the Invention]

[0009] The present invention provides an oral composition that can maintain stability, such as by suppressing enzyme inactivation and denaturation, and that can exhibit good foaming and foam retention. [Modes for carrying out the invention]

[0010] [1. Ingredients and composition of oral composition] The oral composition of the present invention contains components (A) to (C).

[0011] [1.1 Ingredient A: Enzyme] Component (A) is an enzyme. Component (A) allows the composition to exhibit functions based on its enzyme activity.

[0012] As the enzyme, an enzyme capable of exhibiting enzyme activity that brings about functions required for oral compositions, such as decomposition and removal of plaque (biofilm) on tooth surfaces, in periodontal pockets, and on the tongue, prevention of dental caries, and suppression of its progression, is preferable. Examples of such enzymes include protease and glucanase. As the glucanase, an enzyme that acts on polysaccharides involved in diseases (e.g., dental caries) in the oral cavity is preferable, and examples include dextranase, mutanase, α -amylase, β -amylase, pullulanase, glucoamylase, α -glucosidase, isoamylase, cellulase (including β -glucanase), and hemicellulase, with dextranase being preferable. Dextranase can exhibit effects of decomposing and removing dental plaque and suppressing the formation of dental plaque.

[0013] The protease may be either an endopeptidase or an exopeptidase (aminopeptidase, carboxypeptidase), but an endopeptidase is preferable. Examples of endoproteases include cysteine proteases such as papain, bromelain, and actinidin, and serine proteases such as nattokinase, with cysteine proteases being preferable, papain, bromelain, and actinidin being more preferable, and papain being even more preferable. Papain can exhibit the effect of removing tongue coating and stains.

[0014] Component (A) may be one type of enzyme or a combination of two or more types, and preferably contains any one or more of dextranase, mutanase, actinidin, papain, and bromelain, and more preferably contains dextranase and / or papain.

[0015] As the enzyme of component (A), one stabilized with an excipient can be used. Commonly used excipients can be used. Examples include sugar alcohols such as sorbitol, mannitol, and maltitol, polyhydric alcohols such as glycerin and propylene glycol, polysaccharides such as dextrin, starch, and crystalline cellulose, and inorganic powders such as silica. Among these, mannitol, dextrin, crystalline cellulose, and glycerin are preferable. The content of the excipient with respect to the enzyme can be adjusted appropriately to an appropriate amount.

[0016] [Content of Component (A)] The content of Component (A) varies depending on the type of enzyme and it is difficult to specify uniformly. However, as enzyme activity, it is preferably 1 U / g or more, more preferably 2 U / g or more, still more preferably 5 U / g or more, and even more preferably 10 U / g or more. Thereby, the blending effect can be exhibited more favorably. The upper limit is preferably 70,000 U / g or less, more preferably 60,000 U / g or less, still more preferably 50,000 U / g or less, even more preferably 40,000 U / g or less, and particularly preferably 30,000 U / g or less. Therefore, it is preferably 1 to 70,000 U / g, more preferably 2 to 60,000 U / g, still more preferably 5 to 50,000 U / g, even more preferably 10 to 40,000 U / g, and particularly preferably 10 to 30,000 U / g.

[0017] The content of dextranase as component (A) is preferably 1 U / g or more, more preferably 2 U / g or more, even more preferably 5 U / g or more, and even more preferably 10 U / g or more, in terms of enzyme activity (in the composition). This allows the blending effect to be exhibited more effectively. The upper limit is preferably 500 U / g or less, more preferably 200 U or less, even more preferably 150 U / g or less, and even more preferably 100 U / g or less. Therefore, it is 1 to 500 U / g, more preferably 2 to 200 U / g, even more preferably 5 to 150 U / g, and even more preferably 10 to 100 U / g. This suppresses the generation of bitterness during use. The content of dextranase is preferably 0.025% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.125% by mass or more or 0.055% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 0.25% by mass or more, when the enzyme activity is 4000 U / g. This allows the blending effect to be exhibited more effectively. The upper limit is preferably 12.5% ​​by mass or less, more preferably 5% by mass or less, even more preferably 3.75% by mass or less, and particularly preferably 2.5% by mass or less, when the enzyme activity is 4000 U / g. This suppresses the generation of bitterness during use. Therefore, when the enzyme activity is 4000 U / g, it is preferably 0.025 to 12.5% ​​by mass, more preferably 0.05 to 5% by mass, even more preferably 0.125 to 3.75% by mass, and particularly preferably 0.25 to 2.5% by mass.

[0018] The papain content as component (A) is preferably 100 U / g or more, more preferably 200 U / g or more, even more preferably 300 U / g or more, even more preferably 400 U / g or more, and particularly preferably 500 U / g or more, in terms of enzyme activity (in the composition). This allows the blending effect to be exhibited more effectively. The upper limit is preferably 70,000 U / g or less, more preferably 60,000 U / g or less, even more preferably 50,000 U / g or less, even more preferably 40,000 U / g or less, and particularly preferably 30,000 U / g or less. Therefore, it is 1 to 500 U / g or more, more preferably 2 to 200 U / g, even more preferably 5 to 150 U / g, and even more preferably 10 to 100 U / g. This suppresses the generation of bitterness during use. The papain content, when the enzyme activity is 800,000 U / g, is preferably 0.0125% by mass or more, more preferably 0.025% by mass or more, even more preferably 0.0375% by mass or more, even more preferably 0.05% by mass or more, and particularly preferably 0.0625% by mass or more. This allows the blending effect to be exhibited more effectively. The upper limit is preferably 8.75% by mass or less, more preferably 7.5% by mass or less, even more preferably 6.25% by mass or less, even more preferably 5% by mass or less, and particularly preferably 3.753% by mass or less. This suppresses the generation of bitterness during use. Therefore, when the enzyme activity is 800,000 U / g, it is preferably 0.0125 to 8.75% by mass, more preferably 0.025 to 7.5% by mass, even more preferably 0.0375 to 6.25% by mass, even more preferably 0.05 to 5% by mass, and particularly preferably 0.0625 to 3.75% by mass.

[0019] In this specification, unless otherwise specified, the content of each component is based on the amount of each component used when manufacturing the oral composition. Furthermore, unless otherwise specified, it means mass percent relative to 100% by mass of the total amount of the oral composition.

[0020] [1.2 Ingredient (B): Anionic surfactant] Component (B) is an anionic surfactant. Component (B) enables the oral composition to exhibit good foaming and foam retention. The anionic surfactant includes (B-1) and (B-2) below.

[0021] [Component (B-1)] Component (B-1) is one or more selected from the group consisting of alkyl sulfates and acylmethyl taurate salts. (B-1) allows the composition to exhibit an improved foaming effect.

[0022] The alkyl group in alkyl sulfates is usually a straight chain, and the number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. Examples of alkyl sulfates include lauryl sulfate and myristyl sulfate, with lauryl sulfate being preferred.

[0023] The acyl group in acylmethyltaurine salts is usually a straight chain, and its number of carbon atoms is preferably 8 to 20, more preferably 10 to 20, and even more preferably 10 to 18. Examples of acylmethyltaurine salts include lauroylmethyltaurine salt and N-cocoylmethyltaurine salt, with lauroylmethyltaurine salt being preferred.

[0024] The salts of alkyl sulfates and acylmethyl taurine salts can be selected from pharmacokinetically acceptable salts such as base addition salts and amino acid salts, for example, inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0025] Component (B-1) may be one or a combination of two or more, and preferably contains at least sodium lauryl sulfate and / or sodium lauroyl methyl taurate.

[0026] [Component (B-2)] Component (B-2) is one or more selected from acyl sarcosine salt, α-olefin sulfonate, acyl glutamate, and sulfosuccinate. (B-2) allows the composition to exhibit an improved foam retention effect.

[0027] The acyl group in an acyl sarcosine salt is usually a straight chain, and its number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. Examples of acyl sarcosine salts include lauroyl sarcosine salts and myristoyl sarcosine salts, with lauroyl sarcosine salts being preferred.

[0028] The number of carbon atoms in the α-olefin sulfonate is preferably 10 to 20, more preferably 12 to 18, and even more preferably 14 to 16. As the α-olefin sulfonate, tetradecene sulfonate is preferred, for example.

[0029] The acyl group in acyl glutamates is usually a straight chain, and its number of carbon atoms is preferably 8 to 20, more preferably 10 to 20, and even more preferably 10 to 18. Examples of acyl glutamates include cocoyl glutamates and lauroyl glutamates, with lauroyl glutamates being preferred.

[0030] The alkyl group in the sulfosuccinate is usually linear, and its number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. For example, lauryl sulfosuccinate is preferred. The alkyl group may have a polyoxyalkylene group. A polyoxyethylene group is preferred as the polyoxyalkylene group. An example of a sulfosuccinate is polyoxyethylene(2)alkyl(12-14) sulfosuccinate.

[0031] Examples of salts derived from acyl sarcosine salts, α-olefin sulfonates, acyl glutamates, and sulfosuccinates are the same as those in component (B-1).

[0032] Component (B-2) may be one or a combination of two or more, and preferably contains at least one selected from the group consisting of sodium lauroyl sarcosinate, sodium tetradecenesulfonate, sodium lauroyl glutamate, and disodium polyoxyethylene (2) alkyl (12-14) sulfosuccinate.

[0033] [Other anionic surfactants] Component (B) may contain anionic surfactants other than (B-1) and (B-2). Examples include acylglycine salts such as cocoyl glycine salt; acylalanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt; acylmethylalanine salts of N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-cocoyl-N-methyl-β-alanine salt; acyl aspartates such as lauroyl aspartate; hydrogenated coconut fatty acid monoglyceride monosulfate, and lauryl sulfoacetate. The anionic surfactants other than (B-1) and (B-2) may be one type or a combination of two or more types.

[0034] [Content and mass ratio of components (B), (B-1), and (B-2)] The content of component (B) (preferably the sum of the content of components (B-1) and (B-2)) is usually 0.3% by mass or more, preferably 0.4% by mass or more. This allows for a good effect of incorporating component (B). The upper limit is usually 1.2% by mass or less, preferably 1.1% by mass or less, and more preferably 1.0% by mass or less. This suppresses the effect on enzyme activity. Therefore, it is usually 0.3 to 1.2% by mass, preferably 0.3 to 1.1% by mass, more preferably 0.3 to 1.0% by mass, and even more preferably 0.4 to 1.0% by mass.

[0035] The content of component (B-1) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more. This can improve the foaming effect. The upper limit is preferably 1% by mass or less, more preferably 0.9% by mass or less, even more preferably 0.8% by mass or less, even more preferably 0.7% by mass or less, and particularly preferably 0.6% by mass or less. This can maintain the stability of component (A). Therefore, it is preferably 0.1 to 1% by mass, more preferably 0.1 to 0.9% by mass, even more preferably 0.1 to 0.8% by mass, even more preferably 0.2 to 0.7% by mass, and particularly preferably 0.2 to 0.6% by mass.

[0036] The content of component (B-2) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more. This can improve the foam retention effect. The upper limit is preferably 1% by mass or less, more preferably 0.9% by mass or less, even more preferably 0.8% by mass or less, even more preferably 0.7% by mass or less, and particularly preferably 0.6% by mass or less. This can maintain the stability of component (A). Therefore, it is preferably 0.1 to 1% by mass, more preferably 0.1 to 0.9% by mass, even more preferably 0.1 to 0.8% by mass, even more preferably 0.2 to 0.7% by mass or more, and particularly preferably 0.2 to 0.6% by mass.

[0037] The ratio (mass ratio) of the content of (B-1) to the content of (B-2) is preferably 0.15 or more, more preferably 0.2 or more, even more preferably 0.3 or more, even more preferably 0.4 or more, 0.5 or more, or 0.6 or more. This allows for a good balance between foaming and foam retention. The upper limit is preferably 4 or less, more preferably 3.5 or less, even more preferably 3 or less, even more preferably 2 or less, and particularly preferably 1.6 or less. This allows for a good balance between enzyme stability and foam retention. Therefore, it is preferably 0.15 to 4, more preferably 0.2 to 3.5, even more preferably 0.3 to 3, even more preferably 0.4 to 3, and particularly preferably 0.4 to 2.

[0038] [Mass ratio of components (A) and (B)] The ratio of the content of component (A) (enzyme activity: U / g) to the content of (B) (mass %) of the composition is preferably 2 or more, more preferably 5 or more, even more preferably 10 or more, and even more preferably 15 or more. If the enzyme is papain, it is preferably 300 or more, 400 or more, or 500 or more. The upper limit is preferably 80,000 or less, more preferably 70,000 or less, and even more preferably 60,000 or less. If the enzyme is dextrose, it is preferably 500 or less, 400 or less, or 300 or less. Therefore, it is preferably 2 to 80,000, more preferably 5 to 70,000, even more preferably 10 to 60,000, and even more preferably 15 to 60,000. By satisfying any of these conditions, enzyme stability, foam retention, and foaming can be exhibited in a well-balanced manner.

[0039] [1.3 Ingredient (C): Glycyrrhizinate] Component (C) is glycyrrhizinate. Component (C) can improve the stability of component (A).

[0040] Examples of glycyrrhizinate salts include dipotassium glycyrrhizinate and monoammonium glycyrrhizinate, with dipotassium glycyrrhizinate being preferred.

[0041] Component (C) may be one or a combination of two or more, and preferably contains at least dipotassium glycyrrhizinate.

[0042] [Content of ingredient (C)] The content of component (C) is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, and particularly preferably 0.04% by mass or more. This allows for a good stabilization effect of component (A). The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and particularly preferably 0.2% by mass or less. This suppresses the bitterness derived from component (C). Therefore, it is preferably 0.005 to 2% by mass, more preferably 0.01 to 1% by mass, even more preferably 0.02 to 0.5% by mass, even more preferably 0.03 to 0.3% by mass, and particularly preferably 0.04 to 0.2% by mass or less.

[0043] [Mass ratio of components (A) to (C)] The ratio (mass ratio) of the content of component (A) (enzyme activity: U / g) to the total content of components (B) and (C) (A(enzyme activity: U / g) / (B+C)) is preferably 2 or more, more preferably 5 or more, even more preferably 10 or more, and even more preferably 12 or more. If the enzyme is papain, it is preferably 300 or more, 400 or more, or 500 or more. The upper limit is preferably 80,000 or less, more preferably 70,000 or less, and even more preferably 60,000 or less. If the enzyme is dextrose, it is preferably 500 or less, 400 or less, or 300 or less. Therefore, it is preferably 2 to 80,000, more preferably 5 to 70,000, even more preferably 10 to 60,000, and even more preferably 12 to 60,000. By satisfying any of these conditions, enzyme stability, foam retention, and foaming can be exhibited in a well-balanced manner.

[0044] [1.4 Optional components] The oral composition of the present invention may optionally contain components other than components (A) to (C). Examples of optional components include abrasives, surfactants, wetting agents, binders, fragrances, solvents, sweeteners, medicinal ingredients, oily ingredients, preservatives, pH adjusters, and colorants (pigments). Optional components may be present individually or in combination of two or more.

[0045] -Abrasive- Either inorganic or organic abrasives may be used as abrasives. Examples of inorganic abrasives include silica-based abrasives (abrasive silica) such as precipitated silica, crystalline silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica; zeolites; calcium phosphate compounds such as anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, dicalcium phosphate dihydrate or anhydrous, monocalcium phosphate, tricalcium phosphate, and tetracalcium phosphate; calcium carbonate-based abrasives such as calcium carbonate; aluminum hydroxide, alumina, magnesium carbonate, trimagnesium phosphate, calcium sulfate, and zirconium silicate; apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; titanium-based materials such as titanium oxide and titanium dioxide; and minerals such as bentonite. Examples of organic abrasives include polymethyl methacrylate and synthetic resin-based abrasives.

[0046] The abrasive silica is preferably abrasive particles with an average particle size of 1 to 40 μm, and the BET specific surface area of ​​the abrasive silica is preferably 80 to 250 square meters per gram. Here, the average particle size of the abrasive silica is the volume-based median diameter (D50) measured by laser diffraction-scattering.

[0047] There are no particular limitations on the RDA (Radioactive Dentine Abrasion Values) of the abrasive, but it is preferably between 50 and 200. The abrasive may be in the form of granules. Examples of granules include particles obtained by granulating water-insoluble powders (e.g., silica gel, precipitated silica). For example, particles containing pigments such as Red No. 202, No. 205, Red No. 226, Orange No. 203, and Yellow No. 205 may be included. When granulating into granules, any suitable conventionally known binder may be used.

[0048] The abrasive may be a single type or a combination of two or more types. The abrasive content is preferably 7 to 50% by mass, more preferably 10 to 30% by mass.

[0049] -Surfactants (other than component (B))- Any surfactant other than component (B) is acceptable, and examples include nonionic surfactants, amphoteric surfactants, and cationic surfactants.

[0050] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers (e.g., polyoxyethylene stearyl ether), polyoxyethylene-polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters (e.g., decaglycerin fatty acid ester), alkyl glucosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), fatty acid alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate ester), sugar alcohol fatty acid esters (e.g., maltitol fatty acid ester, lactitol fatty acid ester), polyoxyethylene polyoxypropylene copolymer, and polyoxyethylene polyoxypropylene fatty acid ester.

[0051] The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20. The average number of moles of ethylene oxide added to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of the fatty acid alkylolamide is preferably 8 to 20.

[0052] As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred, and polyoxyethylene hydrogenated castor oil with an average ethylene oxide addition number of 5 to 100 moles, or 5 to 60 moles, is more preferred. The nonionic surfactant may be used alone or in combination of two or more types.

[0053] Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine), lauryl imidazolinium betaine, alkyl sulfobetaine (e.g., lauramidopropyl hydroxysultaine), and lecithin. Of these, betaine-type amphoteric surfactants are preferred, fatty acid amidopropyl betaine is more preferred, and coconut oil fatty acid amidopropyl betaine is even more preferred. The amphoteric surfactant may be used alone or in combination of two or more types.

[0054] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. The number of carbon atoms in the alkyl and acyl groups that the cationic surfactant may have may be, for example, 8 to 22 or 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylbenzylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long chain acyl basic amino acid lower alkyl ester salts. Examples of amino acids that may constitute a cationic surfactant include basic amino acids (e.g., natural amino acids such as ornithine, lysine, and arginine, and synthetic amino acids such as α,γ-diaminobutyric acid), and may be either optically active or racemic. The acyl group that the cationic surfactant may have is preferably a saturated or unsaturated higher fatty acid residue, such as a single higher fatty acid residue like a lauroyl group, myristoyl group, palmitoyl group, or stearoyl group; or a natural mixed higher fatty acid residue like coconut oil fatty acid residues or beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, examples include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters.Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate. Cationic surfactants may be used alone or in combination of two or more.

[0055] The surfactant may be a single type or a combination of two or more types. It is preferable to include a nonionic surfactant, anionic surfactant, and amphoteric surfactant, and more preferably to include a nonionic surfactant and / or amphoteric surfactant.

[0056] The content of surfactants (other than (B)) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, it is preferably 0.001 to 10% by mass, more preferably 0.01 to 8% by mass, and even more preferably 0.1 to 5% by mass.

[0057] -Wetting agent- Examples of humectants include sugar alcohols and polyhydric alcohols other than sugar alcohols. Examples of sugar alcohols include sorbitol, xylitol, erythritol, maltitol, lactitol, and reduced starch saccharides; and examples of polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The average molecular weight is the average molecular weight described in the 2021 Japanese Standards for Raw Materials of Quasi-Drugs. One of the above humectants may be used alone, or two or more may be used in combination.

[0058] The humectant content is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and even more preferably 3 to 60% by mass, when the total amount of the oral composition is 100% by mass.

[0059] - Binding agent - Examples of binders include organic binders and inorganic binders. Examples of organic binders include polysaccharides, cellulosic binders (e.g., carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Examples of inorganic binders include thickening silica and aluminum silicate. The binder may be used alone or in combination of two or more types.

[0060] The binder content is preferably 0.001% by mass or more, and more preferably 0.01% by mass or more, in the case of an organic binder. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, 0.001 to 10% by mass or less is preferred, 0.001 to 8% by mass is more preferred, and 0.001 to 5% by mass is even more preferred.

[0061] -Fragrance- Fragrances include, for example, natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, grapefruit oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, and rose oil; Fragrance components contained in the above natural essential oils, such as carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamic aldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, methyl jasmonate, vanillin, germacrene, caryophyllene, viridiflorol, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenol, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furaneol, undecalactone, decalactone, Fragrance components such as ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, menthofran, maltol, ethylmaltol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one, menthyl lactate, ethylene glycol-l-menthyl carbonate, caron, etc.; plant extracts such as chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, vanilla extract, etc.This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, menthol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl monosuccinate, menthyl glutarate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, 3-((-)-mentoxy)propane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-[(ethoxycarbonyl)methyl]-p-menthane-3- Other examples include carboxamide, Np-benzeneasotonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl glyceryl ether, menthyl succinate, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide. The fragrance may contain a solvent, such as ethanol, propylene glycol, glycerin fatty acid ester, or triacetin. The fragrance may be used alone or in combination of two or more types.

[0062] -solvent- Examples of solvents include water and lower monohydric alcohols such as ethyl alcohol (e.g., those with 1 to 4 carbon atoms).

[0063] -Sweetener- Examples of sweeteners include saccharin, sodium saccharin, aspartame, stevioside, stevia extract, neohesperidin dihydrochalcone, perillartin, thaumatin, aspartylphenylalanine methyl ester, acesulfame potassium, maltitol, and mannitol. Sweeteners may be used individually or in combination of two or more.

[0064] -Medicinal ingredients- Medicinal ingredients include, for example, fluorides such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, pyrrolidone carboxylic acid or its salts (e.g., sodium salts), glycine, proline, arginine, lysine, glutamine, and cysteine; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhetinic acid, Phellodendron bark, and Phellodendron bark extract; cell activators such as sodium chloride and vitamins; and isopropylmethylphenol, cetylpyridinium chloride, and benzalconium chloride. Examples of medicinal ingredients include: antibacterial or antimicrobial agents such as thyme, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventative agents such as zeolites, ethane hydroxydiphosphonate, and polyphosphates; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., tocopherol or its derivatives (e.g., tocopherol acetate)); astringents such as sodium chloride, alum, and lysozyme chloride; peptides such as caropeptides; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When an oral composition contains medicinal ingredients, the amount may be an effective amount within a pharmacologically acceptable range. The medicinal ingredients may be a single ingredient or a combination of two or more.

[0065] -Oily components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used individually or in combination of two or more types.

[0066] - Preservatives - Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, and methyl parahydroxybenzoic acid. The preservative may be used alone or in combination of two or more types.

[0067] - pH adjuster - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters may be used individually or in combination of two or more.

[0068] -Coloring agent- As colorants, water-soluble dyes are preferred due to their high safety. Examples include Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and Red No. 106.

[0069] Examples of other optional components include inorganic compounds such as zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention.

[0070] [2. Dosage Forms and Uses of Oral Compositions] The dosage form of the oral composition is not particularly limited. Examples of dosage forms include liquids (liquid bodies such as solutions, emulsions, suspensions, and syrups), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneads, molten solids, waxy solids, elastic solids, soft capsules, etc.). Preferably, the dosage form of the oral composition is a liquid, a semi-solid, and preferably a semi-solid.

[0071] Oral compositions can be widely used in various oral applications such as foods, quasi-drugs, and cosmetics. Examples of solid dosage forms include lozenges, gummies, gums, and toothpastes. Examples of semi-solid dosage forms include toothpastes and gel toothpastes. Examples of liquid dosage forms include mouthwashes, liquid toothpastes, and oral fresheners (sprays, etc.).

[0072] The pH of the oral composition (at 25°C) is preferably near neutral, and more preferably between 5 and 9. The pH can be adjusted by adding pH adjusters, changing the component composition, etc.

[0073] The viscosity of oral compositions can be adjusted according to the dosage form and application. For example, in the case of paste or gel forms, the viscosity at 25°C measured with a BH viscometer is preferably 1 to 300 Pa·s, and more preferably 20 to 150 Pa·s. In the case of liquid forms, the viscosity at 25°C measured with a BL viscometer is preferably 1000 mPa·s or less, and more preferably 0.7 to 100 mPa·s, and more preferably 0.7 to 30 mPa·s.

[0074] [3. Method for producing oral compositions] The method for producing the oral composition of the present invention is not particularly limited. In the case of a toothpaste composition, for example, one method of production involves preparing a component soluble in a solvent, mixing in an insoluble component, and, if necessary, degassing by, for example, reducing pressure, before placing the mixture in a container.

[0075] The shape and material of the container are not particularly limited. Examples of container materials include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon. Containers in which the innermost layer is made of linear low-density polyethylene (LLDPE) or polyethylene (LE) are particularly preferred. In the case of toothpaste, a laminated tube is preferred, and in the case of liquid preparations, a container (bottle) capable of holding the liquid is preferred. [Examples]

[0076] The present invention will be described in detail below with reference to examples. The following examples are one embodiment of the present invention and are not intended to limit it.

[0077] Examples 1-30 and Comparative Examples 1-6 [Manufacturing of toothpaste composition (toothpaste)] The raw materials shown in the table were blended using conventional methods to obtain a toothpaste composition. The obtained toothpaste composition was then placed in a conventionally known and suitable container (laminated tube). The resulting toothpaste composition was evaluated using the method described below.

[0078] [Evaluation of toothpaste compositions] (1) Method for evaluating enzyme stability The toothpaste composition was filled into 50g laminate tubes and stored for 3 weeks at 45°C and 75% RH. After returning to room temperature, the toothpaste composition was subjected to the following tests according to the enzyme species it contained.

[0079] (i) Measurement of dextranase enzyme activity First, 0.6 g of the toothpaste composition was suspended in 0.1 M phosphate buffer to form a suspension, and the supernatant obtained by centrifugation of the resulting suspension was used as the test solution. The amount of 0.1 M phosphate buffer added when forming the suspension can be adjusted according to the amount of dextranase contained in the toothpaste composition. For example, if the amount of dextranase was 0.5%, 15 mL of 0.1 M phosphate buffer was used. 1 mL of the resulting test solution was added to 2 mL of 1% dextran solution and reacted in a 35°C bath for exactly 10 minutes. The amount of reducing sugar produced was measured using the Somogyi-Nelson method. One unit of dextranase enzyme activity was defined as the amount of dextranase capable of producing free reducing sugar equivalent to 1 μmol of glucose per minute.

[0080] (ii) Measurement of papain enzyme activity The enzyme activity of papain was measured in accordance with the "Method for Measuring Enzyme Activity" described in the "Papain" section of the 10th edition of the Japanese Food Additives Compendium. For the preparation of the test solution used for measuring enzyme activity, 0.5 g of the toothpaste composition was first suspended in a diluent to form a suspension, and the supernatant obtained by centrifugation of the resulting suspension was used as the test solution. The amount of diluent added to form the suspension was adjusted according to the amount of papain in the toothpaste composition. For example, if the papain content was 0.3%, 20 mL of diluent was used.

[0081] The enzyme activity in the toothpaste composition before preservation treatment and the enzyme activity in the toothpaste composition after preservation treatment were measured, and the enzyme retention rate (in %) was calculated using the following formula. Enzyme retention rate (%) = (Enzyme activity after preservation treatment) / (Enzyme activity before preservation treatment) × 100

[0082] In this embodiment, the enzyme retention rate was measured three times, and the stability of the enzyme was evaluated based on the average value of the three results using the following evaluation criteria.

[0083] (Evaluation Criteria) ◎(Good): Enzyme residual rate 90% or more ○ (Acceptable): Enzyme retention rate 80% or more but less than 90% × (Not acceptable): Enzyme retention rate less than 80%

[0084] (2) Evaluation of the feel of the foam The product was evaluated through a sensory test using 10 expert panelists. Approximately 1g of the toothpaste composition was placed on a toothbrush (Clinica Advantage toothbrush, 4-row compact, regular type, manufactured by Lion Corporation), and teeth were brushed for 3 minutes in the same manner as usual. The foaming and foam retention during use were evaluated as follows.

[0085] (i) Evaluation of foaming The foaming of the toothpaste composition in the oral cavity at the start of brushing (20 seconds after brushing begins) was evaluated according to the following scoring criteria.

[0086] (Scoring Criteria) 4 points: Sufficient lathering and excellent user experience. 3 points: It lathers up nicely, and the user experience is satisfying. 2 points: The amount of lather is small, and the user experience is somewhat inferior. 1 point: It hardly lathers at all, making it unpleasant to use.

[0087] Toothpaste compositions that achieved a foaming level rated ◎ (Good) or ○ (Acceptable) when evaluated according to the following evaluation criteria, based on the average score obtained by averaging the evaluation results (scores) of 10 individuals, were evaluated as good toothpaste compositions.

[0088] (Evaluation Criteria) ◎(Good): Average score 3.5 points or more and 4.0 points or less ○ (Acceptable): Average score between 3.0 and 3.5 points. × (Fail): Average score below 3.0 points

[0089] (ii) Evaluation of foam retention The foam retention of toothpaste compositions in the oral cavity after brushing was evaluated according to the following scoring criteria.

[0090] (Scoring Criteria) 4 points: The foam remains in the mouth sufficiently until the end of brushing, providing a superior user experience. 3 points: A moderate amount of foam remains in the mouth until the end of brushing, and the user experience is satisfactory. 2 points: The amount of foam in the mouth after brushing is small, resulting in a slightly inferior user experience. 1 point: There is almost no foam left in the mouth after brushing, resulting in a poor user experience.

[0091] Toothpaste compositions that achieved foam retention rated ◎ (Excellent) or ○ (Good) when evaluated according to the following evaluation criteria based on the average score obtained by averaging the evaluation results (scores) of 10 individuals were evaluated as good toothpaste compositions.

[0092] (Evaluation Criteria) ◎(Good): Average score 3.5 points or more and 4.0 points or less ○ (Acceptable): Average score between 3.0 and 3.5 points. × (Fail): Average score below 3.0 points

[0093] [Table 1]

[0094] [Table 2]

[0095] [Table 3]

[0096] [Table 4]

[0097] [Table 5]

[0098] [Footnotes for Tables 1-5] *A / B: This is the ratio of the enzyme units (U / g) of component A to the content (mass%) of component B. Note that the values ​​in the table (excluding B-1 / B-2, A / B, A / B+C, and the average and average scores of the evaluations) represent the content (mass%) relative to 100% of the total amount of the composition in each example.

[0099] [Raw materials] Dextranase: Manufactured by Mitsubishi Chemical Corporation, product name "Dextranase 2F", enzyme activity 4000 U / g Papain: Manufactured by Mitsubishi Chemical Corporation, product name "Purified Papain", enzyme activity 800,000 U / g Dipotassium glycyrrhizinate: Manufactured by Tokyo Chemical Industry Co., Ltd., product name "Dipotassium Glycyrrhizinate" Sodium lauryl sulfate: Manufactured by BASF Japan, trade name "Texapon (registered trademark)" Sodium lauroyl methyl taurate: Manufactured by Nikko Chemicals Co., Ltd., product name "NIKKOL LMT-P" Sodium tetradecenesulfonate: Manufactured by Lion Specialty Chemicals, product name "K Liporan PJ-400CJ" Sodium lauroyl sarcosinate: Manufactured by Kawaken Fine Chemicals Co., Ltd., product name "Soypon SLP (registered trademark)" Sodium lauroyl glutamate: Manufactured by Asahi Kasei Finechem Co., Ltd., product name "AminoSurfact® ALMS-P1" Disodium polyoxyethylene (2) alkyl(12-14) sulfosuccinate: Manufactured by Sanyo Chemical Industries, Ltd., product name "Viewlight ESS" Sodium carboxymethylcellulose: Manufactured by Daicel Mirise, product name "CMC1260" Abrasive silica: Manufactured by Evonik, product name "Zeodent(registered trademark) 124" Thickening silica: Manufactured by DSL Japan, product name "Carplex(registered trademark) #67" Fragrance composition A: As shown in the table below.

[0100] In the comparative toothpaste, enzyme stability, foaming, or foam retention were inferior, whereas the example toothpaste received favorable evaluations in all three aspects with a good balance. These results indicate that the oral composition of the present invention can maintain enzyme stability and exhibits good foaming and foam retention.

[0101] [Example prescription] [Table 6]

[0102] [Table 7]

[0103] [Footnotes for Tables 6 and 7] *1: Coconut oil fatty acid amidopropyl betaine solution: A 30% pure solution was used, and the amount of the solution used is indicated. *2: Silica granules (average particle size 250 μm): Tosoh Silica Co., Ltd. NIPGEL (registered trademark) AY-001 *3: Silica granules (average particle size 100 μm): Tosoh Silica Co., Ltd. NIPGEL (registered trademark) AY-002 The values ​​in the table represent the content (mass%) relative to 100% of the total amount of each example composition.

[0104] [Fragrance composition] [Table 8]

[0105] [Table 9]

[0106] [Table 10]

[0107] [Table 11]

[0108] [Table 12]

[0109] In Examples 1-30 and Formulation Examples 1-11 described above, samples with the same composition were prepared, except that fragrance compositions B-S were used instead of fragrance composition A. It was found that all samples maintained enzyme stability and exhibited good foaming and foam retention.

Claims

1. Ingredient (A): Enzyme Component (B) Anionic surfactant containing (B-1) and (B-2) (B-1) Alkyl sulfates and / or acylmethyl taurine salts (B-2) One or more selected from the group consisting of α-oleisulfonates, acylsarcosine salts, acylglutamates, and sulfosuccinates. (C) Glycyrrhizinate Includes, The content of component (B) is 0.3 to 1.3% by mass. Oral composition.

2. The oral composition according to claim 1, wherein component (A) comprises one or both of glucanase and protease.

3. The oral composition according to claim 1, wherein component (A) comprises one or more selected from the group consisting of dextranase, mutanase, actinidine, papain, and bromelain.

4. Component (A) contains dextranase, The enzymatic activity of dextranase is between 2 U / g and 200 U / g. The oral composition according to claim 3.

5. Component (A) contains papain, The enzyme activity of papain ranges from 400 U / g to 40,000 U / g. The oral composition according to claim 3.

6. The oral composition according to any one of claims 1 to 5, wherein the content of (B-1) is 0.1 to 0.8% by mass.

7. The oral composition according to any one of claims 1 to 5, wherein the content of (B-2) is 0.1 to 0.8% by mass.

8. The oral composition according to any one of claims 1 to 5, wherein the content of component (B) is 0.3 to 1.0% by mass.

9. The oral composition according to any one of claims 1 to 5, wherein the ratio of the content of (B-2) to the content of (B-1) is 0.15 to 4.

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