Use of organic acid metal compounds as animal feed additives

Abstract

This invention belongs to the field of animal feed additives and, more specifically, relates to the use of organic acid metal compounds and / or solvates as animal feed additives or in the manufacture of animal feed additives. The organic acid metal compounds and / or solvates according to the present invention can effectively increase the body weight of animals, improve feed efficiency, have a good effect in improving the productivity of animals, and when administered to animals, the organic acid metal compounds and / or solvates according to the present invention do not substantially remain in the tissues such as the muscles and liver of edible animals.

Description

[Technical Field]

[0001] The present invention relates to the field of animal feed additives, and more specifically to the use of organic acid metal compounds and / or their solvates as animal feed additives, or their use in the manufacture of animal feed additives. [Background technology]

[0002] There are various types of organic aluminum compounds, with a wide range of applications. Common examples include aluminum formate and aluminum acetate. Aluminum formate is often used as a catalyst in organic synthesis reactions, particularly esterification reactions, where it promotes ester formation and improves reaction rates and yields, such as in the synthesis of amino acid esters. As a wood preservative, aluminum formate helps protect wood from fungi, insects, and other organisms. It penetrates the surface of the wood and binds to the fibers to form a protective film, extending the lifespan of the wood. Aluminum formate can be used as an ingredient in several dyes and pigments, and can also be added to pulp as a paper strength improver. Aluminum acetate has antibacterial, anti-inflammatory, and antipruritic effects. In the early 20th century, aluminum acetate was used in pharmaceuticals and dyes as a preservative, astringent, and antipyretic. Aluminum acetate can also be used as a catalyst and color fixative in the dyeing and tanning processes of leather.

[0003] In addition, organic aluminum compounds have been disclosed and are used in the manufacture of polyurethane foam, or as anti-caking agents, stabilizers, or viscosity modifiers in foundations, sunscreens, and moisturizing creams, or as nucleating agents and surfactants in plastic processing, or as one of the components of defoamers, or as one of the components of conductive slurries in the manufacture of chip resistor electrodes, or as one of the components of grease compositions, or in polyester catalyst compositions. However, there are no reports yet on the application of organic aluminum compounds in the feed industry and animal husbandry. [Overview of the project]

[0004] Based on this, the present invention provides the use of an organic acid metal compound and / or its solvate as an animal feed additive or in the manufacture of an animal feed additive, and further provides a composition comprising the organic acid metal compound and / or its solvate.

[0005] To achieve the above object of the present invention, the present invention provides the use of an organic acid metal compound of the molecular formula Al m , 5 , m , 12 , 12 , 12 , 12 (R 1 ) n (R 2 ) n (R 3 ) n and / or its solvate as an animal feed additive or in the manufacture of an animal feed additive, where n is any natural number, R 1 is selected from Y-C(O)O- or a plant polyphenol, and R 2 and R 3 are each independently selected from -OH, Y-C(O)O- or a plant polyphenol, Y is H, a straight-chain or branched C1-C 19 alkyl group or a straight-chain or branched C1-C 4 alkyl group substituted with 1 to 5 R 19 a C3-C7 cycloalkyl group or a C3-C7 cycloalkyl group substituted with 1 to 5 R 4 a C3-C7 cycloheteroalkyl group or a C3-C7 cycloheteroalkyl group substituted with 1 to 5 R 4 a C5-C 12 aryl group or a C5-C 5 aryl group substituted with 1 to 5 R 12 a C5-C 12 heteroaryl group or a C5-C 5 heteroaryl group substituted with 1 to 5 R 12 -(CH=CH) m -(C5-C 12 aryl group) or a -(CH=CH) 5 substituted with 1 to 5 R 12 aryl group of C5-C m -(C5-C[[ID=Aryl group), -(CH=CH) m -(C5-C 12 (heteroaryl group) or 1 to 5 R 5 C5-C 12 -(CH=CH) with a heteroaryl group substituted m -(C5-C 12 Selected from heteroaryl groups, m is any natural number, R 4 is -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I. R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy group, -C1-C5 alkyl group, or -C1-C5 alkyl group substituted with X2, where X2 is selected from F, Cl, Br or I.

[0006] The present invention further provides a composition comprising the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n The mixture contains an organic acid metal compound and / or a solvate thereof, preferably the organic acid metal compound and / or a solvate thereof being an effective component.

[0007] This invention relates to the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Further providing the use of a composition comprising an organic acid metal compound and / or a solvate thereof as an animal feed additive, or in the manufacture of an animal feed additive, preferably the animal feed additive being an animal growth promoter.

[0008] The present invention provides a method for improving the production performance of animals, the method being based on the molecular formula Al n (R 1 ) n (R2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n This includes administering to animals a composition containing an organic acid metal compound and / or a solvate thereof.

[0009] The present invention has demonstrated through animal farming trials that the organic acid metal compounds and / or solvates thereof according to the present invention can effectively increase the body weight of animals, improve feed efficiency, and have a good effect in improving the productivity of animals. Furthermore, it is noteworthy that the organic acid metal compounds and / or solvates thereof according to the present invention do not substantially remain in the tissues of edible animals such as muscles and livers, and the aluminum element content is below the detection limit of instruments of aluminum element detection laboratories, or below the aluminum element content in commercially available meat, or below the aluminum element content in the meat of edible animals in a blank control group that was not administered the organic acid metal compounds, thus complying with the aluminum residue requirements in food specified in the Food Additive Use Standard GB2760-2014, with an aluminum residue amount of ≤100 mg / kg (equivalent to 100 ppm), (dry sample, Al equivalent).

[0010] Any embodiment of any one aspect of the present invention can be combined with other embodiments, provided that this does not conflict with the invention. Furthermore, any technical feature in any one embodiment of any one aspect of the present invention can be applied to the same technical feature in other embodiments, provided that this does not conflict with the invention.

[0011] The above description merely outlines some aspects of the present invention, but is not limited to these aspects. The above and other aspects are described more specifically and completely below. [Modes for carrying out the invention]

[0012] The following detailed description is intended to enable those skilled in the art to carry out different embodiments. Descriptions of specific equipment, techniques, or applications are merely examples. The present invention is intended to encompass all alternative, modified, and equivalent technical proposals, all of which fall within the scope of the invention as defined in the claims. Furthermore, some technical features of the present invention are described individually in several independent embodiments for clarity, but may also be provided in combination in a single embodiment or in any suitable subcombination. Organic acid metal compounds related to the present invention

[0013] This invention relates to the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n This relates to organic acid metal compounds and / or solvates thereof.

[0014] Here, n is any natural number, and R 1 It is selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols. Y is C1-C of H, a straight or branched chain. 19 Alkyl group or 1 to 5 R 4 C1-C in a linear or branched chain that has been substituted with 19 Alkyl alkyl groups, C3-C7 cycloalkyl groups, or 1 to 5 R groups 4 A C3-C7 cycloalkyl group substituted with a C3-C7 cycloheteralkyl group, or 1 to 5 R 4 C3-C7 cycloheteralkyl groups substituted with C5-C 12 Aryl group or 1 to 5 R 5 C5-C replaced by 12 Aryl group, C5-C 12 Heteroaryl group or 1 to 5 R 5 C5-C replaced by 12A heteroaryl group, -(CH=CH) m -(C5-C 12 aryl group) or 1 to 5 R 5 wherein the C5-C 12 aryl group-substituted -(CH=CH) m -(C5-C 12 aryl group), -(CH=CH) m -(C5-C 12 heteroaryl group) or 1 to 5 R 5 wherein the C5-C 12 heteroaryl group-substituted -(CH=CH) m -(C5-C 12 heteroaryl group), selected from m is an arbitrary natural number, R 4 is -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I, R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy group, -C1-C5 alkyl group, or a -C1-C5 alkyl group substituted with X2, where X2 is selected from F, Cl, Br or I.

[0015] Generally, "substituted" means that one or more replaceable hydrogen atoms in the given structure are replaced by specific substituents, and one substituted group may have one substituent at each replaceable position of the group. When multiple positions in the given structural formula are replaceable by one or more substituents of a specific substituent, the substitution method of the substituents at each position may be the same or different.

[0016] In the present invention, "C a -C b alkyl group" represents a linear or branched saturated alkyl group containing a to b carbon atoms, such as a methyl group, an ethyl group, a propyl group, an isopropyl group,... For example, "C1-C5 alkyl group" represents a linear or branched saturated alkyl group containing 1 to 5 carbon atoms.

[0017] In this invention, "CH=CH" represents an olefin fragment with the structure -HC=CH-, and (CH=CH) m This represents a conjugated olefin fragment in which m -HC=CH- groups are linked by single bonds.

[0018] GB987715A, GB190708576A, GB190708643A, and GB182446A disclose existing processes for producing Al salts of organic acids, and these processes and their variations can be used to produce the above-mentioned organic acid metal compounds, and the R related to their structure 2 and R 3 If R is not OH, 2 and R 3 R 1 It may be the same or different.

[0019] The material form of the organic acid metal compound according to the present invention may be a monomer or a polymer.

[0020] The monomers related to this invention are those with the molecular formula Al(R 1 )(R 2 )(R 3 This refers to organic acid metal compounds that are )

[0021] The polymer relating to this invention is a polymer with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n This refers to an organic acid metal compound, where n is a natural number greater than 2.

[0022] In some manufacturing methods, reaction substrates with multiple active functional groups may cause reaction selectivity problems during the reaction process. Therefore, the products obtained by the above-mentioned manufacturing methods for organic acid metal compounds have the molecular formula Al n (R 1 ) n (OH) n (OH) n , Al n (R 1 ) n(R 2 ) n (OH) n and Al n (R 1 ) n (R 2 ) n (R 3 ) n It consists of one or more of the compounds, R 1 It is selected from YC(O)O or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols, preferably R 1 , R 2 and R 3 In this manufacturing form, represents YC(O)O- or plant polyphenols.

[0023] The "plant polyphenols" in this invention refer to secondary metabolites having a polyphenol structure derived from natural plants, and include, but are not limited to, curcumin, grape polyphenols, elladic acid, magnolol, Cornus officinalis extract, tea polyphenols, hydrolyzed tannins, chestnut tannins, grapefruit tannins, and tannic acid.

[0024] In some specific manufacturing methods, the above product is preferably of the molecular formula Al n (R 1 ) n (OH) n (OH) n , Al n (R 1 ) n (R 1 ) n (OH) n and Al n (R 1 ) n (R 1 ) n (R 1 ) n It consists of one or more of the compounds, R 1 , R 2 and R 3 In this manufacturing form, represents YC(O)O- or plant polyphenols.

[0025] In some manufacturing methods, the resulting product is R 1 Selected from plant polyphenols, R 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH or plant polyphenols.

[0026] In some specific manufacturing methods, the resulting product is R 1 R is selected from tannic acid. 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH or tannic acid.

[0027] The "tannic acid" in this invention refers to tannin obtained from galls, and is also called tannic acid, tannic acid, tannin, or tanni.

[0028] In some manufacturing methods, the resulting product is R 1 is selected from YC(O)O-, R 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH and YC(O)O-, where Y is a linear or branched C1-C 15 Alkyl group or 1 to 5 R 4 C1-C substituted in linear or branched chains 15 Selected from alkyl groups, R 4 is -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I.

[0029] In some embodiments, the resulting product is R 1 is selected from YC(O)O-, R 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH and YC(O)O-, where Y is a C4-C5 cycloheteralkyl group or 1 to 5 R groups. 4 Selected from C4-C5 cycloheteralkyl groups substituted with R 4is -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I.

[0030] In some embodiments, the resulting product is R 1 is selected from YC(O)O-, R 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH and YC(O)O-, where Y is a phenyl group or 1 to 5 R groups. 5 Selected from phenyl groups substituted with R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy group, -C1-C5 alkyl group, or -C1-C5 alkyl group substituted with X2, where X2 is selected from F, Cl, Br or I.

[0031] In some embodiments, the resulting product is R 1 is selected from YC(O)O-, R 2 and R 3 Each of these is an organic acid metal compound independently selected from -OH and YC(O)O-, where Y is a C4-C5 heteroaryl group or 1 to 5 R 5 Selected from C4-C5 heteroaryl groups substituted with, the heteroaryl group is a heteroaryl group containing O, S or N, and R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy group, -C1-C5 alkyl group, or -C1-C5 alkyl group substituted with X2, where X2 is selected from F, Cl, Br or I.

[0032] In some embodiments, Y in the organic acid metal compound and / or its solvate is a 3-pyridyl group.

[0033] In some embodiments, the R of an organic acid metal compound and / or its solvate 1 is selected from YC(O)O-, R 2 and R 3These are independently selected from -OH and YC(O)O-, and Y is -(CH=CH) m - Phenyl group or 1 to 5 R groups 5 -(CH=CH) with a phenyl group substituted m - Selected from phenyl groups, where m is any natural number, R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy group, -C1-C5 alkyl group, or -C1-C5 alkyl group substituted with X2, where X2 is selected from F, Cl, Br or I.

[0034] In some embodiments, the R of an organic acid metal compound and / or its solvate 1 is selected from YC(O)O-, R 2 and R 3 Each of these is independently selected from -OH and YC(O)O-, and Y is selected from the -(CH=CH)-phenyl group.

[0035] In some embodiments, the organic acid metal compound solvate in the organic acid metal compound and / or its solvate is selected from one, more or a combination thereof of the organic acid metal compound hydrate, acetone solvate, ethanol solvate, methanol solvate, dimethyl sulfoxide solvate, ethyl acetate solvate, acetic acid solvate, and / or isopropanol solvate.

[0036] In some embodiments, the organic acid metal compound and / or its solvate is selected from one or more organic acid metal compounds of the same or different molecular formulas, one or more organic acid metal compound solvates of the same or different molecular formulas, or a combination of one or more organic acid metal compounds of the same or different molecular formulas and one or more organic acid metal compound solvates of the same or different molecular formulas.

[0037] In some embodiments, the organic acid metal compound comprises an organic acid metal compound monomer or an organic acid metal compound polymer.

[0038] In some of the manufacturing embodiments, the organic acid metal compound is one of the compounds shown below in molecular formula, Al n (OH) 2n (CH3COO) n (Abbreviated as "ethyl Al"), Al n (OH) 2n (CH3(CH2)2COO) n (Abbreviated as "butylal"), Al n (OH) 2n (CH3(CH2)8COO) n (Abbreviated as "Decil Al"), Al n (OH) 2n (CH3(CH2) 12 COO) n (Abbreviated as "14Al"), Al n (OH) 2n (CH3(CH2) 14 COO) n (Abbreviated as "palmitin A") [ka] (Abbreviated as "phenylalanyl") [ka] (Abbreviated as "NAl") [ka] (Abbreviated as "KAl") [ka] (Abbreviated as "RAl").

[0039] In some of these manufacturing embodiments, the organic acid metal compound is one of the following combinations.

[0040] "Ethyl Al combination" is Al n (OH) 2n (CH3COO) n , Al n (OH) n (CH3COO)2n and Al n (CH3COO) 3n It is one or more combinations of the following: "Butyl Al combination" is Al n (OH) 2n (CH3(CH2)2COO) n , Al n (OH) n (CH3(CH2)2COO) 2n , and Al n (CH3(CH2)2COO) 3n It is one or more combinations of the following: "Decile-Al combination" is Al n (OH) 2n (CH3(CH2)8COO) n , Al n (OH) n (CH3(CH2)8COO) 2n and Al n (CH3(CH2)8COO) 3n It is one or more combinations of the following: "14Al combination" is Al n (OH) 2n (CH3(CH2) 12 COO) n , Al n (OH) n (CH3(CH2) 12 COO) 2n and Al n (CH3(CH2) 12 COO) 3n It is one or more combinations of the following: "Palmitin Al combination" is Al n (OH) 2n (CH3(CH2) 14 COO) n , Al n (OH) n (CH3(CH2) 14 COO) 2n and Al n (CH3(CH2) 14 COO) 3n It is one or more combinations of the following: "Phenyl Al combination" is [ka] It is one or more combinations of the following: "NAl combination" is, [ka] It is one or more combinations of the following: "KAl combination" is, [ka] It is one or more combinations of the following: "RAl combination" is, [ka] It is one or a combination of these.

[0041] The "organic acid metal compound" according to the present invention includes an organic acid metal compound monomer or an organic acid metal compound polymer, and further includes one or more combinations of organic acid metal compounds of the same or different molecular formulas.

[0042] In some embodiments, the process for producing the organic acid metal compound also involves the separation, purification, or recrystallization of the reaction product. The reaction product can be obtained from the reaction system by desolvation to obtain a crude product. To obtain a solid substance with higher chemical purity and lower impurity content, the crude product is dissolved, crystallized, precipitated, or recrystallized in an alcohol solvent, an alcohol-water mixture, or another organic solvent usable for product recrystallization, under appropriate conditions such as temperature, light, and mechanical vibration, to obtain an organic acid metal compound having a specific material form.

[0043] The aforementioned organic acid metal compound having a specific material form is a solvate of the organic acid metal compound. The solvate of the organic acid metal compound may be selected from the hydrate, acetone solvate, ethanol solvate, methanol solvate, dimethyl sulfoxide solvate, ethyl acetate solvate, acetic acid solvate, and isopropanol solvate of the organic acid metal compound.

[0044] The term "solvate" in this invention refers to a eutectic aggregate formed by the bonding of stoichiometric or non-stoichiometric solvent molecules via non-covalent intermolecular forces during the contact process between the compound of this invention and solvent molecules, due to external and internal conditions. The solvents that form the solvate include, but are not limited to, water, acetone, ethanol, methanol, dimethyl sulfoxide, ethyl acetate, acetic acid, and isopropanol. The term "hydrate" refers to a compound in which the solvent molecule is water, and the aggregate or crystal formed therefrom is a compound that bonds stoichiometric or non-stoichiometric water molecules via non-covalent intermolecular forces.

[0045] The "organic acid metal compound and / or solvate thereof" in this invention refers to a selection from one or more organic acid metal compounds of the same or different molecular formulas, one or more organic acid metal compound solvates of the same or different molecular formulas, or a combination of one or more organic acid metal compounds of the same or different molecular formulas and one or more organic acid metal compound solvates of the same or different molecular formulas.

[0046] The bioavailability research tests of the organic acid metal compounds according to the present invention include tests on the effects of the organic acid metal compounds and their solvates on the growth performance of piglets, on the growth performance of broilers, on the production performance of laying hens, and on the effects of applying them to meat duck feed. The research results show that applying the organic acid metal compounds and their solvates to the farming of pigs, chickens, and ducks effectively improves the growth rate of pigs, chickens, and ducks, reduces feed efficiency, improves growth efficiency, and promotes growth.

[0047] The present invention also studies the residual amount of Al element in the muscles or tissues of broilers, meat ducks, pigs, and laying hens when the organic acid metal compounds and their solvates are applied to their feed. As a result, in long-term feeding trials lasting 3 to 6 months, the residual amount of Al element contained in the organic acid metal compounds in the animals was lower than that of the blank control group or below the detection limit of the instruments. In other words, the present invention fully demonstrates that the organic acid metal compounds and their solvates can be applied to the feed of broilers, meat ducks, pigs, and laying hens, and that no Al element remains in the muscles or tissues of these animals. Applications of organic acid metal compounds related to the present invention

[0048] Based on research results on the bioavailability of organic acid metal compounds and their solvates, and research results on their persistence in animal bodies, the present invention provides applications of the said organic acid metal compounds and / or their solvates as animal feed additives, or applications in the manufacture of animal feed additives.

[0049] The term "animal" in this invention refers to aquaculture animals that cannot synthesize organic matter from inorganic matter and that use organic matter as food to carry out life activities such as foraging, digestion, absorption, respiration, circulation, excretion, sensation, movement, and reproduction. "Aquaculture animals" include poultry, livestock, aquaculture animals, and other animals that are legally captured through artificial rearing, including pets such as cats and dogs. The term "livestock" is, for example, any one of pigs, cattle, horses, goats, sheep, deer, and many industrially valuable rodents. The term "poultry" includes, for example, chickens, ducks, geese, quail, and pigeons. The term "aquaculture animals" includes, for example, fish, shrimp, turtles, and softshell turtles.

[0050] The organic acid metal compounds and / or solvates thereof according to the present invention may be used as growth promoters for animals at each growth stage, or for use in the manufacture of growth promoters, and said animals may be selected from livestock, poultry, aquaculture animals or other animals including pets at each growth stage.

[0051] Furthermore, the livestock includes, but is not limited to, pigs, cattle, sheep, deer, horses, rabbits, mink, or donkeys; the poultry includes, but is not limited to, chickens, turkeys, ducks, geese, quail, or pigeons; the aquatic animals include, but are not limited to, fish, shrimp, turtles, crabs, softshell turtles, bullfrogs, swamp eels, or loaches; and the pets include, but are not limited to, dogs or cats of any subspecies.

[0052] In one embodiment, the organic acid metal compound and / or solvate thereof according to the present invention is used as a feed additive to improve the production performance of market pigs, or is used in the manufacture of a feed additive, and the feed additive has a significant improvement effect on both the average daily weight gain and feed efficiency of market pigs.

[0053] In another embodiment, the organic acid metal compound and / or solvate thereof according to the present invention is used as a feed additive to improve the production performance of broilers or laying hens, or is used in the manufacture of a feed additive, and the feed additive can significantly improve the production performance of broilers or laying hens.

[0054] In another embodiment, the organic acid metal compound and / or solvate thereof according to the present invention is used as a feed additive to improve the production performance of meat ducks, or is used in the manufacture of a feed additive, and the feed additive can significantly improve the production performance of meat ducks.

[0055] In another embodiment, the organic acid metal compound and / or solvate thereof according to the present invention is used as a feed additive to improve the productivity of fish, or is used in the manufacture of a feed additive, and the feed additive can significantly improve the productivity of fish. Composition according to the present invention

[0056] The "composition" according to the present invention is a group or aggregate of compounds containing one or more compounds, and further, a group or aggregate of compounds containing one or more compounds as an active ingredient or component.

[0057] The composition according to the present invention comprises the above-mentioned organic acid metal compound and / or its solvate, and further, the active ingredient or component contained in the composition is the above-mentioned organic acid metal compound and / or its solvate.

[0058] The aforementioned organic acid metal compound and / or its solvate is of the molecular formula Al n (R 1 ) n (OH) n (OH) n , Al n (R 1 ) n (R 2 ) n (OH) n and Al n (R 1 ) n (R 2 ) n (R 3 ) n It consists of one or more of the compounds, R 1 It is selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols, preferably with the molecular formula Al n (R 1 ) n (OH) n (OH) n , Al n (R 1 ) n (R 1 ) n (OH) n and Al n (R 1 ) n (R 1 ) n (R 1 ) n It consists of one or more of the compounds, R 1 , R 2 and R 3 This represents YC(O)O- or plant polyphenols.

[0059] Furthermore, the composition comprising the above-mentioned organic acid metal compound and / or its solvate according to the present invention further comprises one or a combination thereof of feed supplementary ingredients, additional animal feed additives, and animal feed ingredients.

[0060] Furthermore, the organic acid metal compound solvate in the organic acid metal compound and / or its solvate according to the present invention is selected from one, more, or a combination thereof of the organic acid metal compound hydrate, acetone solvate, ethanol solvate, methanol solvate, dimethyl sulfoxide solvate, ethyl acetate solvate, acetic acid solvate, and / or isopropanol solvate.

[0061] Furthermore, the above-mentioned organic acid metal compounds and / or solvates thereof are selected from one or more organic acid metal compounds of the same or different molecular formulas, one or more organic acid metal compound solvates of the same or different molecular formulas, or a combination of one or more organic acid metal compounds of the same or different molecular formulas and one or more organic acid metal compound solvates of the same or different molecular formulas.

[0062] Furthermore, the above-mentioned organic acid metal compound includes an organic acid metal compound monomer or an organic acid metal compound polymer.

[0063] The term "includes" as used in this invention is an open expression and includes the content explicitly mentioned in this invention, but does not exclude other content.

[0064] Furthermore, the aforementioned feed supplementary material is selected from one or more of the following: carrier, diluent, excipient, and solvent.

[0065] The "carrier" according to the present invention refers to a feed substance that can support an active ingredient, improve its dispersibility, and has good chemical stability and adsorption properties, and includes organic carriers and inorganic carriers. The organic carrier is selected from materials that contain a large amount of crude fiber and includes, but is not limited to, corn flour, corn cob powder, wheat bran, rice husk powder, defatted rice bran, mixed powder of rice husk and rice bran, corn stalk and leaf powder, peanut shell powder, etc. The inorganic carrier is selected from minerals, and further selected from calcium salts and silicon oxides, and is used in the production of trace element premixes and includes, but is not limited to, calcium carbonate, silicates, vermiculite, zeolite, sepiolite, etc.

[0066] The "diluent" according to the present invention refers to a substance that uniformly distributes additive raw materials into a material and dilutes high-concentration additive raw materials into a low-concentration premix or premix, separating trace components from each other, reducing the interaction between active components, and improving the stability of active components, without affecting the physical and chemical properties of related substances, and includes organic diluents and inorganic diluents. Organic diluents include, but are not limited to, corn flour, sprouted corn flour, dextrose (glucose), sucrose, bran-containing semolina flour, roasted soy flour, wheat midling, and corn gluten meal, and inorganic diluents include, but are not limited to, limestone, calcium dihydrogen phosphate, shell powder, kaolin (white clay), salt, and sodium sulfate.

[0067] The "excipient" according to the present invention refers to a wetting agent that induces viscosity inherent to the substance itself, an adhesive that bonds substances together, a disintegrant that breaks a sheet-like substance into many fine particles, a retaining aid that reduces interparticle friction, or an anti-adhesion agent that prevents materials from adhering together, and includes, but is not limited to, magnesium stearate, talc, vegetable oil, magnesium lauryl sulfate, starch, starch slurry, water, inorganic salts, dextrin, powdered sugar, etc.

[0068] The "vehicle" according to the present invention is a solvent necessary for the dissolution or dispersion of a solid, and includes, but is not limited to, water, ethanol, and glycerin.

[0069] The term "feed additive" in this invention refers to a small or trace amount of substance added during the processing, manufacturing, and use of feed, and includes both nutritional feed additives and general feed additives, also known as non-nutritional feed additives.

[0070] The "animal feed additive" in this invention refers to one or more of the following: nutritional feed additives, general feed additives, or drug feed additives.

[0071] The "nutritional feed additives" in this invention refer to small or trace amounts of substances added to compound feeds to balance feed nutrients, improve feed utilization, and directly provide nutritional effects to animals. These substances include amino acids, amino acid salts and their analogues, vitamins and retinoid vitamins, mineral elements and their complexes (chelates), microbial enzyme preparations, or non-proteinoid nitrogen.

[0072] The "general feed additives" in this invention, also known as "non-nutrient additives," are several non-nutrient substances added to feed to improve feed utilization and guarantee feed quality and grade, and are beneficial to the health or metabolism of animals. These include growth promoters, insect repellents, flavorings and attractants, feed adjusters, feed compounders, feed preservatives, and herbal medicine additives.

[0073] In this invention, "feed" refers to a product that is industrially processed and manufactured for animal consumption. Unless otherwise specified, the term "feed" or "animal feed" includes animal feed ingredients and one or more animal feed additives. In some embodiments, the animal feed ingredients include feed substances such as grains and their processed products, oilseeds and their processed products, leguminous crop seeds and their processed products, tubers, rhizomes and their processed products, other seeds, fruit products and their processed products, feed, roughage and their processed products, other plants, algae and their processed products, dairy products and their by-products, terrestrial animal products and their by-products, fish, other aquatic organisms and their by-products, minerals, microbial fermentation products and their by-products, and other feed ingredients. Use of the composition

[0074] The present invention relates to the use of compositions comprising the above-mentioned organic acid metal compounds and / or solvates thereof, and further relates to the use of compositions comprising the above-mentioned organic acid metal compounds and / or solvates thereof as active ingredients or components.

[0075] In some embodiments, the composition or feed composition containing the organic acid metal compound and / or its solvate is applied as an animal feed additive or in the manufacture of an animal feed additive.

[0076] Applications of compositions or feed compositions containing the aforementioned organic acid metal compounds and / or solvates thereof as animal feed additives, or applications in the manufacture of animal feed additives, wherein the animal feed additives are selected from livestock feed additives, poultry feed additives, aquaculture animal feed additives, or pet feed additives. Specifically, the animal feed additives are animal growth promoters.

[0077] Specifically, the application of a composition or feed composition containing the aforementioned organic acid metal compound and / or its solvate as a livestock feed additive, or in the manufacture of livestock feed additives, wherein the livestock includes, but is not limited to, pigs, cattle, sheep, horses, rabbits, mink, etc., at each growth stage.

[0078] Specifically, the application of a composition or feed composition containing the aforementioned organic acid metal compound and / or its solvate as a poultry feed additive, or in the manufacture of a poultry feed additive, wherein the poultry includes, but is not limited to, chickens, ducks, geese, and pigeons at each growth stage.

[0079] Specifically, the application of a composition or feed composition containing the aforementioned organic acid metal compound and / or its solvate as an additive for aquaculture animal feed, or in the manufacture of an additive for aquaculture animal feed, wherein the aquaculture animals include, but are not limited to, fish at each growth stage, shrimp, crabs, softshell turtles, swamp eels, etc.

[0080] Specifically, the application of a composition or feed composition containing the aforementioned organic acid metal compound and / or its solvate as a pet feed additive, or in the manufacture of a pet feed additive, wherein the pet includes, but is not limited to, artificially bred dogs or cats.

[0081] Specifically, the application of the composition or feed composition containing the organic acid metal compound and / or its solvate as an animal feed additive, or in the manufacture of an animal feed additive, wherein the animal feed additive manufactured with the composition or feed composition of the organic acid metal compound and / or its solvate is selected from a premix, a compound premix, an aqueous solution, or granules.

[0082] In some embodiments, the application of a composition or feed composition containing the organic acid metal compound and / or its solvate is to animal feed or to the manufacture of animal feed.

[0083] Specifically, the composition or feed composition containing the aforementioned organic acid metal compound and / or its solvate, or the animal feed produced therefrom, is selected from livestock feed, poultry feed, farmed animal feed, or pet feed.

[0084] Specifically, a composition or feed composition containing an organic acid metal compound and / or its solvate, or livestock feed produced therefrom, wherein the livestock includes, but is not limited to, pigs, cattle, sheep, horses, rabbits, mink, etc., at each growth stage.

[0085] Specifically, a composition or feed composition containing an organic acid metal compound and / or a solvate thereof, or poultry feed produced therefrom, wherein the poultry includes, but is not limited to, chickens, ducks, geese, pigeons, etc., at each growth stage.

[0086] Specifically, a composition or feed composition containing an organic acid metal compound and / or a solvate thereof, or a feed for aquaculture animals produced therefrom, wherein the aquaculture animals include, but are not limited to, fish, shrimp, crabs, softshell turtles, and swamp eels at each growth stage.

[0087] Specifically, a composition or feed composition containing an organic acid metal compound and / or a solvate thereof, or pet feed manufactured therefrom, wherein the pet includes, but is not limited to, artificially bred dogs or cats.

[0088] In some embodiments, a composition or feed composition comprising an organic acid metal compound and / or a solvate thereof is applied as feed or in the manufacture of feed, wherein the feed is selected from single feeds, concentrated feeds, compound feeds, complex premixes or complementary feeds.

[0089] Specifically, the aforementioned compound feed is a complete compound feed. Methods to improve the productivity of farmed animals

[0090] The method for improving the production performance of animals according to the present invention is based on the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n This includes administering organic acid metal compounds and / or solvates thereof to animals, or the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n This includes administering to animals a composition containing an organic acid metal compound and / or a solvate thereof as an active ingredient.

[0091] In some embodiments, the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or solvates thereof, or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 )n A composition containing the active ingredients of an organic acid metal compound and / or its solvate can be administered to animals together with feed, and the production performance of the animals can be significantly improved by the administration of the organic acid metal compound and / or its solvate, or the composition.

[0092] In some embodiments, the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n The organic acid metal compound and / or its solvate are uniformly mixed with animal feed and then administered to the animal.

[0093] In some embodiments, the composition of the organic acid metal compound and / or its solvate is selected from a premix, a complex premix, granules, or aqueous solution, and the molecular formula is Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition containing the active ingredients of an organic acid metal compound and / or its solvate is uniformly mixed with animal feed and then administered to the animal.

[0094] Specifically, the animals are selected from livestock, poultry, aquaculture animals, or pets.

[0095] Specifically, the livestock includes, but is not limited to, pigs, cattle, sheep, horses, rabbits, mink, etc., at each stage of growth; the poultry includes, but is not limited to, chickens, ducks, geese, pigeons, etc., at each stage of growth; the aquaculture animals include, but are not limited to, fish, shrimp, crabs, soft-shelled turtles, swamp eels, etc., at each stage of growth; and the pets include, but are not limited to, dogs or cats that have been raised in captivity.

[0096] One embodiment, molecular formula Al n (R 1 ) n (R 2 ) n (R 3) n Organic acid metal compounds and / or solvates thereof, or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition containing an active ingredient of an organic acid metal compound and / or its solvate is administered to weaned piglets together with feed, and this administration method can significantly improve the weight gain rate and feed efficiency of the average daily weight gain of weaned piglets.

[0097] One embodiment, molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or solvates thereof, or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition containing the active ingredients of an organic acid metal compound and / or its solvate is administered to broilers together with feed, and this administration method can significantly reduce the feed conversion ratio of broilers and improve feed efficiency.

[0098] One embodiment, molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or solvates thereof, or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition containing the active ingredients of an organic acid metal compound and / or its solvate is administered to fish together with feed.

[0099] One embodiment, molecular formula Aln (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or solvates thereof, or molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition containing an active ingredient of an organic acid metal compound or its solvate is administered to puppies together with feed.

[0100] In some other embodiments, the above molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n By administering a composition containing an active ingredient of an organic acid metal compound and / or its solvate to an animal, the production performance of the animal can be significantly improved by this administration method.

[0101] Optionally, the composition is selected from feed additive premixes, feed additive complex premixes, granules, or aqueous formulations, and / or administered to animals together with feed.

[0102] In one embodiment, the composition is a feed additive premix.

[0103] In one embodiment, the composition is a feed additive complex premix.

[0104] Optionally, the composition may be a concentrated feed, compound feed, complex premix, or supplemental feed, or may be administered directly to an animal as animal feed.

[0105] In one embodiment, the composition is a complete feed.

[0106] To further clarify the object, technical proposal, and advantages of the present invention, the compounds, compositions, and applications of the present invention will be described in more detail below through examples. It should be understood that the specific examples described herein are used solely to interpret the present invention and are not intended to limit it.

[0107] Example 1: Effects of organic acid metal compounds on the growth performance of piglets Twenty hundred 45-day-old Duroc-Landrace-Large Yorkshire three-way crossbreed piglets of similar weight were randomly divided into 10 treatment groups. Each group consisted of two replicates, with an equal number of males and females, and 10 piglets in each replicate. The specific groupings are shown in Table 1. Before the experiment, the pigpens and equipment were disinfected. During the experiment, pigs were raised in individual compartments in the same pigpen under the same feeding and management conditions. Throughout the experiment, the test pigs had free access to food and water. Group A was the blank control group and was given only growth feed, while groups B through H were given growth feeds containing different organic acid metal compounds. No other antioxidants or growth promoters were added to any of the test groups throughout the feeding process. The experiment cycle was 28 days, and the growth performance of the test pigs was statistically analyzed. The average daily feed intake (ADFI, g / d* head), average daily weight gain (ADG, g / d* head), and feed conversion ratio (FCR) of experimental pigs are expressed as "average values" and are shown in Table 1.

[0108] Feed conversion ratio (FCR) = average daily feed intake / average daily weight gain. Weight gain rate = (Test group ADG - Control group ADG) / Control group ADG * 100% Feed intake improvement rate = (Test group ADFI - Control group ADFI) / Control group ADFI * 100% Feed conversion ratio reduction rate = (Control group FCR - Test group FCR) / Control group FCR * 100%.

[0109] [Table 1]

[0110] The above results indicate that the organic acid metal compounds involved in the study had a significant improvement or enhancement effect on the feed efficiency of the test pigs, which was reflected in the fact that the feed conversion ratio was reduced by 9.82% to 11.90% compared to the blank control group. Furthermore, considering weight gain, the average daily weight gain in the test group increased by 12.25% to 25.64% compared to the blank control group, and considering feed intake, butyl aluminum, decyl aluminum, palmitic aluminum, phenyl aluminum, and Nal were able to increase the feed intake of the test pigs to different degrees.

[0111] Example 2: Effects of organic acid metal compounds on broiler growth performance The study employed a single-factor randomization design. Sixty hundred yellow-feather broilers with similar body weights (average weight 50g) at one day old were selected and randomly divided into 10 treatment groups. Each group consisted of three replicates, with 20 yellow-feather broilers in each replicate, equal numbers of males and females. The group assignments are shown in Table 2. The chicken houses and equipment were disinfected before the study. During the study period, the chickens were raised in cages in the same chicken houses under the same feeding and management conditions. The basal diet consisted mainly of corn-soybean meal, and no other antioxidants or growth promoters were added throughout the feeding process. Study A was the control group, fed only the basal diet, while Study Groups B-H had 250 ppm of organic acid metal compounds added to their basal diet, as shown in Table 2. The study period totaled 20 days, and the test chickens had free access to food and water, and were fed twice a day. In each replicate unit, body weight was measured at 21 days of age (without feeding for 12 hours, but watering was not stopped), the feed intake of the test chickens was statistically analyzed, and the average daily feed intake (ADFI, g / d* birds), average daily weight gain (ADG, g / d* birds), and feed conversion ratio (FCR) of the test chickens in each group were calculated using the following formulas.

[0112] Feed conversion ratio (FCR) = average daily feed intake / average daily weight gain. Weight gain rate = (Test group ADG - Control group ADG) / Control group ADG * 100% Feed intake improvement rate = (Test group ADFI - Control group ADFI) / Control group ADFI * 100% Feed conversion ratio reduction rate = (Control group FCR - Test group FCR) / Control group FCR * 100%.

[0113] The test results are shown in Table 2.

[0114] [Table 2]

[0115] The results above indicate that the organic acid metal compounds used in the study had a significant improvement or enhancement effect on the feed intake, average daily weight gain, and feed efficiency of the test chickens. Compared to the blank control group, the feed intake of the test chickens in the study group increased by 9.40% to 29.87%, the average daily weight gain increased by 25.89% to 50.89%, and the feed conversion ratio decreased by 11.95% to 14.13%.

[0116] Example 3: Application study of organic acid metal compounds in meat duck feed. A single-factor experimental design was employed. 480 Cherry Valley meat ducks, all one day old, with nearly identical body weight and good health, were selected and randomly divided into eight treatment groups. Each treatment group consisted of three replicates, with 20 ducks in each replicate. The control group received a blank feed, consisting of a corn and soybean meal-based basal diet. The other treatment groups were sample-added groups, each supplemented with a different organic acid metal compound. The experiment lasted a total of 42 days. The specific animal groupings are shown in Table 3. During the experiment, the ducks were free to eat and drink, and received vaccinations according to standard vaccination procedures. The feeding status, feed consumption, and mortality rates of the test ducks in each group were observed and recorded daily. The fasting body weight of the ducks was measured at the beginning and end of the experiment. After the experiment, the average daily body weight gain, average daily feed intake, and feed conversion ratio for each treatment group were statistically analyzed per replicate. The results are shown in Table 3.

[0117] [Table 3]

[0118] The above results indicate that the organic acid metal compounds involved in the study had a significant improvement or enhancement effect on the feed intake, average daily weight gain, and feed efficiency of the test ducks. Compared to the blank control group, the feed intake of the test ducks in the test group increased by 7.26% to 23.46%, the average daily weight gain increased by 19.06% to 38.90%, and the feed conversion ratio decreased by 10.42% to 11.99%.

[0119] Example 4: Study on the effects of aluminum benzoate compounds on the production performance of laying hens. A stable, high-line gray laying hen flock (277 days old, 38,395 birds) was subjected to a two-week period of normal production data statistics. Afterward, aluminum benzoate compound (abbreviated as "phenylalanine") (500 grams / ton) was added to the complete feed, and the hen flock was observed for 33 days. Following this, the experiment continued for another 33 days using a complete feed without added phenylalanine. Data such as egg production, mortality, feed intake, and temperature / humidity were statistically collected daily, and the data was compiled into one experimental phase every two weeks. The entire experiment consisted of five phases: pre-control (14 days), aluminum benzoate salt I (14 days), aluminum benzoate salt II (19 days), post-control I (14 days), and post-control II (19 days). Additionally, a random sample of eggs was taken each week to test the thickness and strength of the eggshells.

[0120] Detailed production performance data is as follows: (1) Improvement in egg production rate: The egg production rate of the chicken flock improved from 91.71% in the pre-control stage to 93.57% (phenylalanine I) and 93% (phenylalanine II), and after discontinuation of use, the egg production rate decreased to 91.72% (post-control I) and 91.96% (post-control II), corresponding to the pre-control stage. (2) Improvement in feed conversion ratio: The feed conversion ratio in the pre-control stage was 2.063:1, and the feed conversion ratio in the test stage improved significantly to 2.0:1 (phenylalanine I) and 1.970:1 (phenylalanine I). II) decreased, and the feed conversion ratio after discontinuing the use of phenylalanine was 1.976 (post-control I) and 1.996 (post-control II), respectively. (3) Decrease in daily feed intake: After using phenylalanine, the average daily feed intake decreased from 116.79 grams to 115.27 grams (aluminum benzoate I) and 112.69 grams (phenylalanine II), and (4) there was no significant change in eggshell thickness.

[0121] The overall statistical analysis of the test data clearly demonstrated that after the use of phenylalanine, the intestinal health of the chicken flock improved, egg production increased, feed conversion ratio decreased, daily feed intake decreased, and average egg weight tended to decline. Furthermore, the production performance of the chicken flock after discontinuation of phenylalanine continued to show an improving trend, indicating persistent after-effects.

[0122] Example 5: Residual Analysis Study of Different Organic Acid Metal Compounds in Different Animals 1. Test animals: White-feathered broiler chickens (1 day old), yellow-feathered broiler chickens (1 day old), meat ducks (1 day old), pigs (15 kg), laying hens (eggs)

[0123] 2. Test method: 1. High doses of organic acid metal compounds were added to the feed, and muscle or tissue samples were collected at different ages during a long-term feeding trial lasting 3 to 6 months. The Al content was measured and is shown in Tables 4 to 10.

[0124] 2. The test design includes a blank control group without the addition of organic acid metal compounds.

[0125] The content of Al in the feed after adding different metal organic acid compounds was tested.

[0126] III. Test Results (I) Test Results of White-Feathered Broilers

[0127] [Table 4] (II) Test Results of Yellow-Feathered Broilers

[0128] [Table 5]

[0129] [Table 6]

[0130] [Table 7] (III) Test Results of Egg-Laying Hens: The content of Al in eggs is the content of Al detected in eggs before or 1 - 4 weeks after the use of metal organic acid compounds.

[0131] [Table 8] (IV) Test Results of Ducks

[0132] [Table 9] (V) Test Results of Pigs

[0133] [Table 10]

[0134] The present invention has demonstrated through animal farming trials that the organic acid metal compounds and / or solvates thereof according to the present invention can effectively increase the body weight of animals, improve feed efficiency, and have a good effect in improving the productivity of animals. Furthermore, it is noteworthy that the organic acid metal compounds and / or solvates thereof according to the present invention do not substantially remain in the tissues of edible animals such as muscles and livers, and the aluminum element content is below the detection limit of instruments of aluminum element detection laboratories, or below the aluminum element content in commercially available meat, or below the aluminum element content in the meat of edible animals in a blank control group that was not administered the organic acid metal compounds, thus complying with the aluminum residue requirements in food specified in the Food Additive Use Standard GB2760-2014, with an aluminum residue amount of ≤100 mg / kg (equivalent to 100 ppm), (dry sample, Al equivalent).

[0135] The embodiments described above represent only a few embodiments of the present invention, and while the descriptions are relatively specific and detailed, this should not be understood as limiting the scope of the patent. It should be noted that those skilled in the art will be able to make various modifications and improvements without departing from the concept of the present invention, and all of these fall within the scope of protection of the present invention. Therefore, the scope of protection of the patent for the present invention should be in accordance with the appended claims.

Claims

1. Molecular formula Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ The use of organic acid metal compounds and / or their solvates as animal feed additives, or in the manufacture of animal feed additives, Here, n is an arbitrary natural number, and R １ is selected from Y-C(O)O- or a plant polyphenol, and R ２ and R ３ are each independently selected from -OH, Y-C(O)O- or a plant polyphenol, Y is H, a straight or branched C １ -C １９ Alkyl alkyl group or 1 to 5 R ４ Linear or branched chain C substituted with １ -C １９ alkyl group, C ３ -C ７ Cycloalkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloalkyl groups, C ３ -C ７ Cycloheteralkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloheteralkyl groups, C ５ -C １２ Aryl group or 1 to 5 R ５ C replaced by ５ -C １２ Aryl group, C ５ -C １２ Heteroaryl group or 1 to 5 R ５ C replaced by ５ -C １２ Heteroaryl group, -(CH=CH) ｍ - (C ５ -C １２ (aryl group) or 1 to 5 R ５ C ５ -C １２ -(CH=CH) with aryl group substitution ｍ - (C ５ -C １２ Aryl group), -(CH=CH) ｍ - (C ５ -C １２ (heteroaryl group) or 1 to 5 R ５ C ５ -C １２ A heteroaryl group is substituted with -(CH=CH) ｍ - (C ５ -C １２ Selected from heteroaryl groups, m is any natural number, R ４ is -OH, -NH ２ -CN, -SH, or -X １ Selected from, here, X １ is selected from F, Cl, Br, or I, R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, where X ２ The element used is selected from F, Cl, Br, or I.

2. The molecular formula of the aforementioned organic acid metal compound and / or its solvate is Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ And here, R １ It is selected from plant polyphenols, R ２ and R ３ Each is independently selected from -OH or plant polyphenols, preferably R １ It is tannic acid, and R ２ and R ３ The use according to claim 1, characterized in that each is independently selected from OH or tannic acid.

3. The compound molecular formula of the organic acid metal compound and / or its solvate is Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ wherein R １ is selected from Y-C(O)O-, R ２ and R ３ are each independently selected from -OH or Y-C(O)O-, Y is a straight-chain or branched-chain C １ -C １５ alkyl group or a straight-chain or branched-chain C ４ substituted with 1 to 5 R １ -C １５ alkyl group, R ４ is selected from -OH, -NH ２ , -CN, -SH or -X １ wherein X １ is selected from F, Cl, Br or I, Alternatively, here, R １ is selected from Y-C(O)O-, R ２ and R ３ Each is independently selected from -OH or Y-C(O)O-, where Y is C ４ -C ５ Cycloheteralkyl groups or 1 to 5 R groups ４ C replaced by ４ -C ５ Selected from cycloheteralkyl groups, R ４ is -OH, -NH ２ -CN, -SH, or -X １ Selected from, here, X １ is selected from F, Cl, Br, or I, Alternatively, here, R １ is selected from Y-C(O)O-, R ２ and R ３ Each is independently selected from -OH or Y-C(O)O-, where Y is a phenyl group or 1 to 5 R groups. ５ Selected from phenyl groups substituted with R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, where X ２ is selected from F, Cl, Br, or I, Alternatively, here, R １ is selected from Y-C(O)O-, R ２ and R ３ Each is independently selected from -OH or Y-C(O)O-, where Y is C ４ -C ５ Heteroaryl group or 1 to 5 R ５ C replaced by ４ -C ５ Selected from heteroaryl groups, the heteroaryl group is a heteroaryl group containing O, S, or N, and R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, where X ２ is selected from F, Cl, Br, or I, and preferably Y is a 3-pyridyl group. Alternatively, here, R １ is selected from Y-C(O)O-, R ２ and R ３ Each is independently selected from -OH or Y-C(O)O-, where Y is -(CH=CH) ｍ - Phenyl group or 1 to 5 R ５ The phenyl group was substituted with -(CH=CH) ｍ - Selected from phenyl groups, where m is any natural number, R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, where X ２ The use according to claim 1, characterized in that is selected from F, Cl, Br, or I, and preferably Y is selected from a -(CH=CH)-phenyl group.

4. The use according to claim 1, characterized in that the aforementioned organic acid metal compound and / or solvate thereof is used as an animal growth promoter, used as an animal feed additive, or used in the manufacture of an animal feed additive.

5. The use according to claim 1, wherein the organic acid metal compound solvate in the organic acid metal compound and / or its solvate is selected from one or more or a combination thereof of hydrates, acetone solvates, ethanol solvates, methanol solvates, dimethyl sulfoxide solvates, ethyl acetate solvates, acetic acid solvates, and / or isopropanol solvates of organic acid metal compounds, preferably the organic acid metal compound and / or its solvate is selected from one or more organic acid metal compounds of the same or different molecular formulas, one or more organic acid metal compound solvates of the same or different molecular formulas, or a combination of one or more organic acid metal compounds of the same or different molecular formulas and one or more organic acid metal compound solvates of the same or different molecular formulas, and more preferably the organic acid metal compound comprises an organic acid metal compound monomer or an organic acid metal compound polymer.

6. A composition wherein the composition has the molecular formula Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ It comprises organic acid metal compounds and / or solvates thereof, Here, n is any natural number from 1 to 10, and R １ is selected from Y-C(O)O- or plant polyphenols, R ２ and R ３ Each is independently selected from -OH, Y-C(O)O-, and plant polyphenols, preferably R １ is selected from Y-C(O)O- or tannic acid, R ２ and R ３ Each is independently selected from -OH, Y-C(O)O-, or tannic acid. Y is H, a straight or branched C １ -C １９ Alkyl alkyl group or 1 to 5 R ４ Linear or branched chain C substituted with １ -C １９ alkyl group, C ３ -C ７ Cycloalkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloalkyl groups, C ３ -C ７ Cycloheteralkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloheteralkyl groups, C ５ -C １２ Aryl group or 1 to 5 R ５ C replaced by ５ -C １２ Aryl group, C ５ -C １２ Heteroaryl group or 1 to 5 R ５ C replaced by ５ -C １２ Heteroaryl group, -(CH=CH) ｍ - (C ５ -C １２ (aryl group) or 1 to 5 R ５ C ５ -C １２ -(CH=CH) with aryl group substitution ｍ - (C ５ -C １２ Aryl group), -(CH=CH) ｍ - (C ５ -C １２ (heteroaryl group) or 1 to 5 R ５ C ５ -C １２ A heteroaryl group is substituted with -(CH=CH) ｍ - (C ５ -C １２ Selected from heteroaryl groups, m is any natural number, R ４ is -OH, -NH ２ -CN, -SH, or -X １ Selected from, the X １ is selected from F, Cl, Br, or I, R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, the X ２ A composition characterized in that is selected from F, Cl, Br, or I.

7. The aforementioned composition has the molecular formula Al ｎ (R １ ) ｎ (OH) ｎ (OH) ｎ , or Al ｎ (R １ ) ｎ (R ２ ) ｎ (OH) ｎ , or Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ This includes one or more or a combination thereof of organic acid metal compounds and / or solvates thereof, where n, R １ , R ２ , R ３ Y, m, R ４ , R ５ , X １ , X ２ The composition according to claim 6, wherein each of the elements is as described in claim 6.

8. The aforementioned composition has the molecular formula Al ｎ (R １ ) ｎ (OH) ｎ (OH) ｎ Al ｎ (R １ ) ｎ (R １ ) ｎ (OH) ｎ and Al ｎ (R １ ) ｎ (R １ ) ｎ (R １ ) ｎ This includes one or more or a combination thereof of organic acid metal compounds and / or solvates thereof, where n, R １ , R ２ , R ３ Y, m, R ４ , R ５ , X １ , X ２ The composition according to claim 6, wherein each of the elements is as described in claim 6.

9. The composition according to any one of claims 6 to 8, wherein the organic acid metal compound solvate in the organic acid metal compound and / or its solvate is selected from one or more or a combination thereof of hydrates, acetone solvates, ethanol solvates, methanol solvates, dimethyl sulfoxide solvates, ethyl acetate solvates, acetic acid solvates, and / or isopropanol solvates of organic acid metal compounds, preferably the organic acid metal compound and / or its solvate is selected from one or more organic acid metal compounds of the same or different molecular formulas, one or more organic acid metal compound solvates of the same or different molecular formulas, or a combination of one or more organic acid metal compounds of the same or different molecular formulas and one or more organic acid metal compound solvates of the same or different molecular formulas, and more preferably the organic acid metal compound comprises an organic acid metal compound monomer or an organic acid metal compound polymer.

10. The composition according to any one of claims 6 to 9, further comprising animal feed ingredients, additional animal feed additives and / or feed supplement ingredients, wherein the additional animal feed additives are selected from at least one of nutritional feed additives, non-nutritional feed additives, or drug feed additives.

11. Use of the composition according to any one of claims 6 to 10 as an animal feed additive, or use in the manufacture of an animal feed additive, wherein the animal feed additive is an animal growth promoter.

12. A method for improving the productivity of animals, The above method uses the molecular formula Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ Organic acid metal compounds and / or their solvates or molecular formula Al ｎ (R １ ) ｎ (R ２ ) ｎ (R ３ ) ｎ The method involves administering to an animal a composition containing an organic acid metal compound and / or a solvate thereof. Here, n is any natural number from 1 to 10, and R １ is selected from Y-C(O)O- or plant polyphenols, R ２ and R ３ Each is independently selected from -OH, Y-C(O)O-, and plant polyphenols, preferably R １ is selected from Y-C(O)O- or tannic acid, R ２ and R ３ Each is independently selected from -OH, Y-C(O)O-, or tannic acid. Y is H, a straight or branched C １ -C １９ Alkyl alkyl group or 1 to 5 R ４ Linear or branched chain C substituted with １ -C １９ alkyl group, C ３ -C ７ Cycloalkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloalkyl groups, C ３ -C ７ Cycloheteralkyl groups or 1 to 5 R groups ４ C replaced by ３ -C ７ Cycloheteralkyl groups, C ５ -C １２ Aryl group or 1 to 5 R ５ C replaced by ５ -C １２ Aryl group, C ５ -C １２ Heteroaryl group or 1 to 5 R ５ C replaced by ５ -C １２ Heteroaryl group, -(CH=CH) ｍ - (C ５ -C １２ (aryl group) or 1 to 5 R ５ C ５ -C １２ -(CH=CH) with aryl group substitution ｍ - (C ５ -C １２ Aryl group), -(CH=CH) ｍ - (C ５ -C １２ (heteroaryl group) or 1 to 5 R ５ C ５ -C １２ A heteroaryl group is substituted with -(CH=CH) ｍ - (C ５ -C １２ Selected from heteroaryl groups, m is any natural number, R ４ is -OH, -NH ２ -CN, -SH, or -X １ Selected from, the X １ is selected from F, Cl, Br, or I, R ５ is -OH, -NH ２ , -NO ２ , -CN, -SH, -X ２ , -C １ -C ５ Alkoxy group, -C １ -C ５ Alkyl group, or X ２ -C replaced by １ -C ５ Selected from alkyl groups, the X ２ This is a method selected from F, Cl, Br, or I.

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