Heparin-functionalized surface, method for preparing the same, and use thereof
A multilayer coating method using priming and heparin-functionalized polymeric conjugates with single-point bonds addresses the peeling issue of heparin coatings, enhancing durability and antithrombin properties on medical devices.
JP2026511887APending Publication Date: 2026-04-14CORLINE SYST
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Patent Information
- Application Number
- JP2025557293
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-03-30
- Filing Date
- 2024-03-28
- Publication Date
- 2026-04-14
AI Technical Summary
Technical Problem
Heparin or heparin conjugate coatings on certain surfaces, such as metal surfaces, tend to peel off, losing their antithrombin properties and reducing their effectiveness over time.
Method used
A multilayer coating method involving priming the surface with a primer at elevated temperatures and using a heparin-functionalized polymeric conjugate with multiple GAG molecules, each bound by single-point bonds, to enhance adhesion and maintain biological activity.
Benefits of technology
The method improves the durability and stability of heparin coatings, maintaining antithrombin properties and increasing the amount of heparin on the surface, thereby preventing blood coagulation and promoting anticoagulant properties.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to a method for preparing a multilayer heparin conjugate coating on a substrate, the method promoting good adhesion to the substrate surface and increasing the number of available heparin molecules.
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