Quinazoline dione compounds and their uses

JP2026516306AActive Publication Date: 2026-05-21EDGEWISE THERAPEUTICS INC
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Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
EDGEWISE THERAPEUTICS INC
Filing Date
2024-03-26
Publication Date
2026-05-21

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Benefits of technology

【0354】 また本明細書では、例えば、開示される化合物および追加の活性剤を、これらの治療剤の共同作用から有益な効果を提供することが意図された特定の処置レジメンの一部として併用投与する併用療法が企図される。組合せの有益な効果としては、それに限定されるものではないが、治療剤の組合せから生じる薬物動態または薬力学的共同作用が挙げられる。組合せにおけるこれらの治療剤の投与は、典型的に、規定された期間(通常、選択された組合せに応じて、数時間、数日、数週、数カ月または数年)にわたって行われる。併用療法は、逐次的方式での複数の治療剤の投与(すなわち、ここでは各治療剤が、異なる時点で投与される)、および実質的に同時方式でのこれらの治療剤または治療剤の少なくとも2つの投与を包含することを意図される。

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Abstract

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.
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Claims

1. Equation (Ia): 【Chemistry 181】 A compound or salt thereof represented by formula (Ia): R ２ teeth: 【Chemistry 182】 Selected from; X １ C(R) １ａ ), N, and N ＋ (-O － ) are selected from; X ２ is selected from C(R １ｂ ), N, and N ＋ (-O － ); X ３ C(R) １ｃ ), N, and N ＋ (-O － ) are selected from; X ４ C(R) １ｄ ), N, and N ＋ (-O － ) are selected from; Here X １ , X ２ , X ３ , and X ４ Two or fewer of these are N or N ＋ (-O － ) and; Y １ C(R) ９ｂＡ ), N, and N ＋ (-O － ) are selected from; Y ２ C(R) ９ｂＢ ), N, and N ＋ (-O － ) are selected from; Y ３ C(R) ９ｂＣ ), N, and N ＋ (-O － ) are selected from; Y ４ C(R) ９ｂＤ ), N, and N ＋ (-O － ) are selected from; Y ５ C(R) ９ｂＥ ), N, and N ＋ (-O － ) are selected from; Here Y １ , Y ２ , Y ３ , Y ４ , and Y ５ At least one of them is N or N ＋ (-O － ) and; Here Y １ , Y ２ , Y ３ , Y ４ , and Y ５ Three or fewer of these are N or N ＋ (-O － ) and; R １ａ , R １ｂ , R １ｃ , and R １ｄ Each is independent of the others: hydrogen; ハロゲン、-NO ２ 、-N ３ 、-CN、-OR １０ａ 、-SR １０ａ 、-N(R １０ａ ) ２ 、-C(O)R １０ａ 、-C(O)N(R １０ａ ) ２ 、-N(R １０ａ )C(O)R １０ａ 、-N(R １０ａ )C(O)N(R １０ａ ) ２ 、-OC(O)N(R １０ａ ) ２ 、-N(R １０ａ )C(O)OR １０ａ 、-C(O)OR １０ａ 、-OC(O)R １０ａ 、-S(O)R １０ａ 、および-S(O) ２ R １０ａ ; C １～６ alkyl, C ２～６ alkenyl, and C ２～６ alkynyl, each of which is halogen, -OR １０ａ , -SR １０ａ , -N(R １０ａ ), ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ), ２ , -N(R １０ａ ), C(O)R １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -N(R １０ａ ), C(O)N(R １０ａ ), ２ , -OC(O)N(R １０ａ ), ２ , -N(R １０ａ ), C(O)OR １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ , -CN, C ３～１０ carbocyclic ring and one or more substituents independently selected from 3- to 10-membered heterocyclic rings, optionally substituted as necessary, where the C ３～１０ carbocyclic ring and 3- to 10-membered heterocyclic rings are each optionally substituted with one or more substituents independently selected from R ９ａ ; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R Ｚ teeth: -CN, -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , and -C(O)OR １０ｚ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｚ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｚ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R Ｃ teeth: hydrogen; -CN、-C(O)R １０ｃ 、-C(O)N(R １０ｃ ) ２ 、-C(O)OR １０ｃ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｃ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｃ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R Ｚ is R Ｃ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｃ It is optionally substituted with one or more substituents selected independently of it; R ５ teeth: hydrogen; ハロゲン、-OR １０ｄ 、-SR １０ｄ 、-N(R １０ｄ ) ２ 、-C(O)R １０ｄ 、-C(O)N(R １０ｄ ) ２ 、-N(R １０ｄ )C(O)R １０ｄ 、-C(O)OR １０ｄ 、-OC(O)R １０ｄ 、-N(R １０ｄ )C(O)N(R １０ｄ ) ２ 、-OC(O)N(R １０ｄ ) ２ 、-N(R １０ｄ )C(O)OR １０ｄ 、-S(O)R １０ｄ 、-S(O) ２ R １０ｄ 、-NO ２ 、-N ３ 、および-CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｄ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｄ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ５ is R ６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｄ It is optionally substituted with one or more substituents selected independently of it; R ６ teeth: hydrogen; ハロゲン、-OR １０ｅ 、-SR １０ｅ 、-N(R １０ｅ ) ２ 、-C(O)R １０ｅ 、-C(O)N(R １０ｅ ) ２ 、-N(R １０ｅ )C(O)R １０ｅ 、-C(O)OR １０ｅ 、-OC(O)R １０ｅ 、-N(R １０ｅ )C(O)N(R １０ｅ ) ２ 、-OC(O)N(R １０ｅ ) ２ 、-N(R １０ｅ )C(O)OR １０ｅ 、-S(O)R １０ｅ 、-S(O) ２ R １０ｅ 、-NO ２ 、-N ３ 、および-CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｅ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｅ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ６ is R ５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｅ It is optionally substituted with one or more substituents selected independently of it; R ７ teeth: hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ８ teeth: hydrogen; -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -C(O)OR １０ｇ , -S(O)R １０ｇ , and -S(O) ２ R １０ｇ ; Halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｇ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｇ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R ９ａ Independently: Halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; R ９ｂＡ , R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ Each is independent of the others: hydrogen; ハロゲン、-NO ２ 、-N ３ 、-CN、-OR １０ｂ 、-SR １０ｂ 、-N(R １０ｂ ) ２ 、-C(O)R １０ｂ 、-C(O)N(R １０ｂ ) ２ 、-N(R １０ｂ )C(O)R １０ｂ 、-N(R １０ｂ )C(O)N(R １０ｂ ) ２ 、-OC(O)N(R １０ｂ ) ２ 、-N(R １０ｂ )C(O)OR １０ｂ 、-C(O)OR １０ｂ 、-OC(O)R １０ｂ 、-S(O)R １０ｂ 、および-S(O) ２ R １０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R ９ｚ Independently: Halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｃ Independently: Halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｄ Independently: Halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｅ Independently: halogen, -OR １０ｅ , -SR １０ｅ , -N(R １０ｅ ), ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ), ２ , -N(R １０ｅ ),C(O)R １０ｅ , -N(R １０ｅ ),C(O)N(R １０ｅ ), ２ , -OC(O)N(R １０ｅ ), ２ , -N(R １０ｅ ),C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｆ Independently: halogen, -OR １０ｆ , -SR １０ｆ , -N(R １０ｆ ), ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ), ２ , -N(R １０ｆ ),C(O)R １０ｆ , -N(R １０ｆ ),C(O)N(R １０ｆ ), ２ , -OC(O)N(R １０ｆ ), ２ , -N(R １０ｆ ),C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｇ Independently: Halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R １０ａ , R １０ｂ , R １０ｚ , R １０ｃ , R １０ｄ , R １０ｅ , R １０ｆ , and R １０ｇ Independently: hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, and those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Here Y １ 1N or N ＋ (-O － ) and Y ２ C(H) and Y ３ C(H) and Y ４ C(H) and Y ５ If C(H); R ７ teeth: Hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each substituent is substituted as needed by one or more substituents independently selected from the original; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. ２～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Y １ C(H) and Y ２ C(H) and Y ３ C(H) and Y ４ C(H) and Y ５ 1N or N ＋ (-O － ) if R ７ teeth: hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each substituent is substituted as needed by one or more substituents independently selected from the original; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. ２～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Y １ C(H) and Y ２ C(H) and Y ３ 1N or N ＋ (-O － ) and Y ４ C(H) and Y ５ If C(H); R Ｃ teeth: --&N---ORR １０ｃ 、-C(O)N(R １０ｃ ) ２ 、-C(O)OR １０ｃ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｃ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Cycloalkyl and 3- to 10-membered heterocycles, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｃ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; and Y １ C(H) and Y ２ C(H) and Y ３ 1N or N ＋ (-O － ) and Y ４ C(H) and Y ５ If C(H); R ７ ha: hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each substituent is substituted as needed by one or more substituents independently selected from the original; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. A compound or a salt thereof, selected from the above.

2. The compound or salt according to claim 1, wherein the compound or salt is neither compound 213 nor 215, nor a salt thereof.

3. X １ , X ２ , X ３ , and X ４ One or less of these is N, and Y １ , Y ２ , Y ３ , Y ４ , and Y ５ A compound or salt according to any one of claims 1 to 2, wherein one or less of the members is N.

4. X １ However, C(R １ａ A compound or salt according to any one of claims 1 to 3, selected from ) and N.

5. X １ However, C(R １ａ A compound or salt according to any one of claims 1 to 4, selected from ).

6. X １ However, C(H), C(F), and C(CN), and C(CH) ３ A compound or salt according to any one of claims 1 to 5, selected from ).

7. X ２ However, C(R １ｂ A compound or salt according to any one of claims 1 to 6, selected from ) and N.

8. X ２ However, N, C(H), C(F), C(CH) ３ A compound or salt according to any one of claims 1 to 7, selected from ), and C(CN).

9. X ３ A compound or salt according to any one of claims 1 to 8, selected from C(H).

10. X ４ A compound or salt according to any one of claims 1 to 9, wherein C(H) is selected.

11. X ３ and X ４ A compound or salt according to any one of claims 1 to 10, wherein is C(H).

12. R １ａ , R １ｂ , R １ｃ , and R １ｄ Each independently: hydrogen; Halogen, -NO ２ , -N ３ -CN, -OR １０ａ ,-SR １０ａ , and -N(R １０ａ ) ２ ; Halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -NO ２ , = O, -N ３ , and C as needed, substituted with one or more substituents independently selected from -CN １～６ Alkyl A compound or salt according to any one of claims 1 to 11, selected from the above.

13. R １ａ , R １ｂ , R １ｃ , and R １ｄ Each of these independently consists of: hydrogen, fluorocarbon, -CN, and C １～６ A compound or salt according to any one of claims 1 to 12, selected from alkyl groups.

14. R １ａ , R １ｂ , R １ｃ , and R １ｄ The compound or salt according to any one of claims 1 to 13, wherein each of the following is independently selected from hydrogen and fluoro.

15. R Ｚ is: -CN, -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , and -C(O)OR １０ｚ ; and halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , = O, -N ３ , C as needed, substituted with one or more substituents independently selected from -CN １～６ A compound or salt according to any one of claims 1 to 14, selected from alkyl groups.

16. R Ｚ However, C １ A compound or salt according to any one of claims 1 to 15, selected from alkyl groups.

17. R Ｃ but: hydrogen; -CN、-C(O)R １０ｃ 、-C(O)N(R １０ｃ ) ２ 、-C(O)OR １０ｃ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ９ｃ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles A compound or salt according to any one of claims 1 to 16, selected from the above.

18. R Ｃ A: A compound or salt according to any one of claims 1 to 17, selected from hydrogen.

19. R ５ but: hydrogen; Halogen, -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -C(O)OR １０ｄ , and -CN; Halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ９ｄ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ９ｄ Each is replaced as needed. A compound or salt according to any one of claims 1 to 18, selected from the above.

20. R ５ ga: Hydrogen and C １～６ A compound or salt according to any one of claims 1 to 19, selected from alkyl groups.

21. R ５ A: A compound or salt according to any one of claims 1 to 20, selected from hydrogen.

22. R ６ but: hydrogen; Halogen, -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -C(O)OR １０ｅ , and -CN; Halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ９ｅ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ９ｅ Each is replaced as needed. A compound or salt according to any one of claims 1 to 21, selected from the above.

23. R ６ ga: Hydrogen and C １～６ A compound or salt according to any one of claims 1 to 22, selected from alkyl groups.

24. R ６ A: A compound or salt according to any one of claims 1 to 23, selected from hydrogen.

25. R ５ R ６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ A carbon ring has one or more R ９ｄ A compound or salt according to any one of claims 1 to 18, which is substituted as necessary.

26. R ５ R ６ The compound or salt according to any one of claims 1 to 18, which together with the other to form a cyclopropyl group.

27. R ５ is hydrogen, and R ６ A compound or salt according to any one of claims 1 to 24, wherein the compound is hydrogen.

28. R ７ ga: hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ C as needed, substituted with one or more substituents independently selected from ,=O and -CN １～６ A compound or salt according to any one of claims 1 to 27, selected from alkyl groups.

29. R ７ A compound or salt according to any one of claims 1 to 28, wherein hydrogen is selected.

30. Y １ However, C(H), C(F), C(CH) ３ A compound or salt according to any one of claims 1 to 29, selected from ) and N.

31. Y ２ However, C(H), C(F), C(CH) ３ A compound or salt according to any one of claims 1 to 30, selected from ), and N.

32. Y ３ The compound or salt according to any one of claims 1 to 31, wherein the compound is selected from N, C(H), C(CN), C(F), C(Cl), and C(OH).

33. Y ３ A compound or salt according to any one of claims 1 to 32, selected from C(CN).

34. Y ４ However, C(H), C(F), C(CH) ３ A compound or salt according to any one of claims 1 to 33, selected from ), and N.

35. Y ５ However, NC C(H), C(F), and C(CH ３ A compound or salt according to any one of claims 1 to 34, selected from ).

36. Y ５ A compound or salt according to any one of claims 1 to 35, wherein C(H) and C(F) are selected.

37. R ２ but, 【Chemistry 183】 A compound or salt according to any one of claims 1, 2, or 4 to 36, selected from the above.

38. R ８ ga: Hydrogen and C １ A compound or salt according to any one of claims 1 to 37, selected from alkyl groups.

39. R ８ A: A compound or salt according to any one of claims 1 to 38, selected from hydrogen.

40. Each R ９ａ Independently: halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , = O, and -CN; and C １～３ Selected from alkyl groups, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ The compound or salt according to any one of claims 1 to 39, which is optionally substituted with one or more substituents independently selected from ,=O, and -CN.

41. R ９ｂＡ , R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ Each independently: hydrogen; halogen, -CN, -OR １０ｂ ,-SR １０ｂ , and -N(R １０ｂ ) ２ ; and halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ C as needed, substituted with one or more substituents independently selected from ,=O and -CN １～６ A compound or salt according to any one of claims 1 to 40, selected from alkyl groups.

42. R ９ｂＡ , R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ Each of these is independently: hydrogen, fluoro, -CN, -OH, and C １ A compound or salt according to any one of claims 1 to 41, selected from alkyl groups.

43. Each R ９ｚ , R ９ｃ , R ９ｅ , R ９ｆ , and R ９ｇ The compound or salt according to any one of claims 1 to 42, wherein the compound is independently selected from fluoro and -CN.

44. Each R １０ａ , R １０ｂ , R １０ｚ , R １０ｃ , R １０ｄ , R １０ｅ , R １０ｆ , and R １０ｇ Independently: Hydrogen and C １～６ A compound or salt according to any one of claims 1 to 43, selected from alkyl groups.

45. Each R １０ａ A compound or salt according to any one of claims 1 to 44, wherein the compound is independently selected from hydrogen.

46. Y １ N or N ＋ (-O － ) or Y ５ N or N ＋ (-O － ) if R ７ The compound or salt according to any one of claims 1 to 45, wherein hydrogen is selected.

47. Y ３ 1N or N ＋ (-O － ) if R Ｃ ha: Selected from hydrogen; and Y ３ 1N or N ＋ (-O － ) if R ７ a: A compound or salt according to any one of claims 1 to 46, selected from hydrogen.

48. Compounds 1, 2, 11, 12, 5, 6, 97, 3, 4, 7, 8, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 27, 28, 29, 30, 47, 105, 106, 98, 99, 100, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 214, 3001, 3002, 3003, 3004, 3005, 3006, 3007, 3008, 3009, 3010, 3011, 3013, 3014, and 3015, or salts of any one of these, as described in any one of claims 1 to 47.

49. Formula (Ib): 【Chemistry 184】 A compound or salt thereof represented by formula (Ib): R １２ teeth, 【Chemistry 185】 Selected from; m is an integer selected from 1, 2, 3, 4, and 5; X １１ C(R) １１ａ ), N, and N ＋ (-O － ) are selected from; X １２ C(R) １１ｂ ), N, and N ＋ (-O － ) are selected from; X １３ C(R) １１ｃ ), N, and N ＋ (-O － ) are selected from; X １４ C(R) １１ｄ ), N, and N ＋ (-O － ) are selected from; Here X １１ , X １２ , X １３ , and X １４ At least one of them is N or N ＋ (-O － ) and; Here X １１ , X １２ , X １３ , and X １４ Two or fewer of these are N or N ＋ (-O － ) and; R １１ａ , R １１ｂ , R １１ｃ , and R １１ｄ Each is independent of the others: Hydrogen; halogen, -NO ２ , -N ３ -CN, -OR １１０ａ ,-SR １１０ａ , -N(R １１０ａ ) ２ , -C(O)R １１０ａ , -C(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)R １１０ａ , -N(R １１０ａ ) C(O)N(R １１０ａ ) ２ , -OC(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)OR １１０ａ , -C(O)OR １１０ａ , -OC(O)R １１０ａ , -S(O)R １１０ａ , and -S(O) ２ R １１０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ａ ,-SR １１０ａ , -N(R １１０ａ ) ２ , -C(O)R １１０ａ , -C(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)R １１０ａ , -C(O)OR １１０ａ , -OC(O)R １１０ａ , -N(R １１０ａ ) C(O)N(R １１０ａ ) ２ , -OC(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)OR １１０ａ , -S(O)R １１０ａ , -S(O) ２ R １１０ａ , -NO ２ , =O, =S, =N(R １１０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ａ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ａ ,-SR １１０ａ , -N(R １１０ａ ) ２ , -C(O)R １１０ａ , -C(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)R １１０ａ , -N(R １１０ａ ) C(O)N(R １１０ａ ) ２ , -OC(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)OR １１０ａ , -C(O)OR １１０ａ , -OC(O)R １１０ａ , -S(O)R １１０ａ , -S(O) ２ R １１０ａ , -NO ２ , =O, =S, =N(R １１０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ａ Each is replaced as needed. Selected from; R １Ｚ teeth: -C(O)R １１０ｚ , -C(O)N(R １１０ｚ ) ２ , -C(O)OR １１０ｚ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ｚ ,-SR １１０ｚ , -N(R １１０ｚ ) ２ , -C(O)R １１０ｚ , -C(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)R １１０ｚ , -C(O)OR １１０ｚ , -OC(O)R １１０ｚ , -N(R １１０ｚ ) C(O)N(R １１０ｚ ) ２ , -OC(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)OR １１０ｚ , -S(O)R １１０ｚ , -S(O) ２ R １１０ｚ , -NO ２ , =O, =S, =N(R １１０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｚ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｚ ,-SR １１０ｚ , -N(R １１０ｚ ) ２ , -C(O)R １１０ｚ , -C(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)R １１０ｚ , -N(R １１０ｚ ) C(O)N(R １１０ｚ ) ２ , -OC(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)OR １１０ｚ , -C(O)OR １１０ｚ , -OC(O)R １１０ｚ , -S(O)R １１０ｚ , -S(O) ２ R １１０ｚ , -NO ２ , =O, =S, =N(R １１０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｚ Each is replaced as needed. Selected from; R １Ｃ teeth: Hydrogen; -C(O)R １１０ｃ , -C(O)N(R １１０ｃ ) ２ , -C(O)OR １１０ｃ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ｃ ,-SR １１０ｃ , -N(R １１０ｃ ) ２ , -C(O)R １１０ｃ , -C(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)R １１０ｃ , -C(O)OR １１０ｃ , -OC(O)R １１０ｃ , -N(R １１０ｃ ) C(O)N(R １１０ｃ ) ２ , -OC(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)OR １１０ｃ , -S(O)R １１０ｃ , -S(O) ２ R １１０ｃ , -NO ２ , =O, =S, =N(R １１０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｃ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｃ ,-SR １１０ｃ , -N(R １１０ｃ ) ２ , -C(O)R １１０ｃ , -C(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)R １１０ｃ , -N(R １１０ｃ ) C(O)N(R １１０ｃ ) ２ , -OC(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)OR １１０ｃ , -C(O)OR １１０ｃ , -OC(O)R １１０ｃ , -S(O)R １１０ｃ , -S(O) ２ R １１０ｃ , -NO ２ , =O, =S, =N(R １１０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｃ Each is replaced as needed. Selected from; R １５ teeth: Hydrogen; halogen, -OR １１０ｄ ,-SR １１０ｄ , -N(R １１０ｄ ) ２ , -C(O)R １１０ｄ , -C(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)R １１０ｄ , -C(O)OR １１０ｄ , -OC(O)R １１０ｄ , -N(R １１０ｄ ) C(O)N(R １１０ｄ ) ２ , -OC(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)OR １１０ｄ , -S(O)R １１０ｄ , -S(O) ２ R １１０ｄ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ｄ ,-SR １１０ｄ , -N(R １１０ｄ ) ２ , -C(O)R １１０ｄ , -C(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)R １１０ｄ , -C(O)OR １１０ｄ , -OC(O)R １１０ｄ , -N(R １１０ｄ ) C(O)N(R １１０ｄ ) ２ , -OC(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)OR １１０ｄ , -S(O)R １１０ｄ , -S(O) ２ R １１０ｄ , -NO ２ , =O, =S, =N(R １１０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｄ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｄ ,-SR １１０ｄ , -N(R １１０ｄ ) ２ , -C(O)R １１０ｄ , -C(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)R １１０ｄ , -N(R １１０ｄ ) C(O)N(R １１０ｄ ) ２ , -OC(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)OR １１０ｄ , -C(O)OR １１０ｄ , -OC(O)R １１０ｄ , -S(O)R １１０ｄ , -S(O) ２ R １１０ｄ , -NO ２ , =O, =S, =N(R １１０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｄ Each is replaced as needed. Selected from; or R １５ is R １６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ A carbon ring has one or more R １９ｄ It is replaced as needed; R １６ teeth: Hydrogen; halogen, -OR １１０ｅ ,-SR １１０ｅ , -N(R １１０ｅ ) ２ , -C(O)R １１０ｅ , -C(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)R １１０ｅ , -C(O)OR １１０ｅ , -OC(O)R １１０ｅ , -N(R １１０ｅ ) C(O)N(R １１０ｅ ) ２ , -OC(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)OR １１０ｅ , -S(O)R １１０ｅ , -S(O) ２ R １１０ｅ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ｅ ,-SR １１０ｅ , -N(R １１０ｅ ) ２ , -C(O)R １１０ｅ , -C(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)R １１０ｅ , -C(O)OR １１０ｅ , -OC(O)R １１０ｅ , -N(R １１０ｅ ) C(O)N(R １１０ｅ ) ２ , -OC(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)OR １１０ｅ , -S(O)R １１０ｅ , -S(O) ２ R １１０ｅ , -NO ２ , =O, =S, =N(R １１０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｅ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｅ ,-SR １１０ｅ , -N(R １１０ｅ ) ２ , -C(O)R １１０ｅ , -C(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)R １１０ｅ , -N(R １１０ｅ ) C(O)N(R １１０ｅ ) ２ , -OC(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)OR １１０ｅ , -C(O)OR １１０ｅ , -OC(O)R １１０ｅ , -S(O)R １１０ｅ , -S(O) ２ R １１０ｅ , -NO ２ , =O, =S, =N(R １１０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｅ Each is replaced as needed. Selected from; or R １６ is R １５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ A carbon ring has one or more R １９ｅ It is replaced as needed; R １７ teeth: Hydrogen; -C(O)R １１０ｆ , -C(O)N(R １１０ｆ ) ２ , -C(O)OR １１０ｆ , -S(O)R １１０ｆ , and -S(O) ２ R １１０ｆ ; Halogen, -OR １１０ｆ ,-SR １１０ｆ , -N(R １１０ｆ ) ２ , -C(O)R １１０ｆ , -C(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)R １１０ｆ , -C(O)OR １１０ｆ , -OC(O)R １１０ｆ , -N(R １１０ｆ ) C(O)N(R １１０ｆ ) ２ , -OC(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)OR １１０ｆ , -S(O)R １１０ｆ , -S(O) ２ R １１０ｆ , -NO ２ , =O, =S, =N(R １１０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｆ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｆ ,-SR １１０ｆ , -N(R １１０ｆ ) ２ , -C(O)R １１０ｆ , -C(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)R １１０ｆ , -N(R １１０ｆ ) C(O)N(R １１０ｆ ) ２ , -OC(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)OR １１０ｆ , -C(O)OR １１０ｆ , -OC(O)R １１０ｆ , -S(O)R １１０ｆ , -S(O) ２ R １１０ｆ , -NO ２ , =O, =S, =N(R １１０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｆ Each is replaced as needed. Selected from; R １８ teeth: Hydrogen; -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -C(O)OR １１０ｇ , -S(O)R １１０ｇ , and -S(O) ２ R １１０ｇ ; Halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｇ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｇ Each is replaced as needed. Selected from; Each R １９ａ Independently: Halogen, -OR １１０ａ ,-SR １１０ａ , -N(R １１０ａ ) ２ , -C(O)R １１０ａ , -C(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)R １１０ａ , -N(R １１０ａ ) C(O)N(R １１０ａ ) ２ , -OC(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)OR １１０ａ , -C(O)OR １１０ａ , -OC(O)R １１０ａ , -S(O)R １１０ａ , -S(O) ２ R １１０ａ , -NO ２ , =O, =S, =N(R １１０ａ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ａ ,-SR １１０ａ , -N(R １１０ａ ) ２ , -C(O)R １１０ａ , -C(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)R １１０ａ , -N(R １１０ａ ) C(O)N(R １１０ａ ) ２ , -OC(O)N(R １１０ａ ) ２ , -N(R １１０ａ ) C(O)OR １１０ａ , -C(O)OR １１０ａ , -OC(O)R １１０ａ , -S(O)R １１０ａ , -S(O) ２ R １１０ａ , -NO ２ , =O, =S, =N(R １１０ａ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｂ Independently: ハロゲン、-NO ２ 、-N ３ 、-CN、-OR １１０ｂ 、-SR １１０ｂ 、-N(R １１０ｂ ) ２ 、-C(O)R １１０ｂ 、-C(O)N(R １１０ｂ ) ２ 、-N(R １１０ｂ )C(O)R １１０ｂ 、-N(R １１０ｂ )C(O)N(R １１０ｂ ) ２ 、-OC(O)N(R １１０ｂ ) ２ 、-N(R １１０ｂ )C(O)OR １１０ｂ 、-C(O)OR １１０ｂ 、-OC(O)R １１０ｂ 、-S(O)R １１０ｂ 、および-S(O) ２ R １１０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １１０ｂ ,-SR １１０ｂ , -N(R １１０ｂ ) ２ , -C(O)R １１０ｂ , -C(O)N(R １１０ｂ ) ２ , -N(R １１０ｂ ) C(O)R １１０ｂ , -C(O)OR １１０ｂ , -OC(O)R １１０ｂ , -N(R １１０ｂ ) C(O)N(R １１０ｂ ) ２ , -OC(O)N(R １１０ｂ ) ２ , -N(R １１０ｂ ) C(O)OR １１０ｂ , -S(O)R １１０ｂ , -S(O) ２ R １１０ｂ , -NO ２ , =O, =S, =N(R １１０ｂ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｂ ,-SR １１０ｂ , -N(R １１０ｂ ) ２ , -C(O)R １１０ｂ , -C(O)N(R １１０ｂ ) ２ , -N(R １１０ｂ ) C(O)R １１０ｂ , -N(R １１０ｂ ) C(O)N(R １１０ｂ ) ２ , -OC(O)N(R １１０ｂ ) ２ , -N(R １１０ｂ ) C(O)OR １１０ｂ , -C(O)OR １１０ｂ , -OC(O)R １１０ｂ , -S(O)R １１０ｂ , -S(O) ２ R １１０ｂ , -NO ２ , =O, =S, =N(R １１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R １９ｚ Independently: Halogen, -OR １１０ｚ ,-SR １１０ｚ , -N(R １１０ｚ ) ２ , -C(O)R １１０ｚ , -C(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)R １１０ｚ , -N(R １１０ｚ ) C(O)N(R １１０ｚ ) ２ , -OC(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)OR １１０ｚ , -C(O)OR １１０ｚ , -OC(O)R １１０ｚ , -S(O)R １１０ｚ , -S(O) ２ R １１０ｚ , -NO ２ , =O, =S, =N(R １１０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｚ ,-SR １１０ｚ , -N(R １１０ｚ ) ２ , -C(O)R １１０ｚ , -C(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)R １１０ｚ , -N(R １１０ｚ ) C(O)N(R １１０ｚ ) ２ , -OC(O)N(R １１０ｚ ) ２ , -N(R １１０ｚ ) C(O)OR １１０ｚ , -C(O)OR １１０ｚ , -OC(O)R １１０ｚ , -S(O)R １１０ｚ , -S(O) ２ R １１０ｚ , -NO ２ , =O, =S, =N(R １１０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｃ Independently: Halogen, -OR １１０ｃ ,-SR １１０ｃ , -N(R １１０ｃ ) ２ , -C(O)R １１０ｃ , -C(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)R １１０ｃ , -N(R １１０ｃ ) C(O)N(R １１０ｃ ) ２ , -OC(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)OR １１０ｃ , -C(O)OR １１０ｃ , -OC(O)R １１０ｃ , -S(O)R １１０ｃ , -S(O) ２ R １１０ｃ , -NO ２ , =O, =S, =N(R １１０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｃ ,-SR １１０ｃ , -N(R １１０ｃ ) ２ , -C(O)R １１０ｃ , -C(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)R １１０ｃ , -N(R １１０ｃ ) C(O)N(R １１０ｃ ) ２ , -OC(O)N(R １１０ｃ ) ２ , -N(R １１０ｃ ) C(O)OR １１０ｃ , -C(O)OR １１０ｃ , -OC(O)R １１０ｃ , -S(O)R １１０ｃ , -S(O) ２ R １１０ｃ , -NO ２ , =O, =S, =N(R １１０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｄ Independently: Halogen, -OR １１０ｄ ,-SR １１０ｄ , -N(R １１０ｄ ) ２ , -C(O)R １１０ｄ , -C(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)R １１０ｄ , -N(R １１０ｄ ) C(O)N(R １１０ｄ ) ２ , -OC(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)OR １１０ｄ , -C(O)OR １１０ｄ , -OC(O)R １１０ｄ , -S(O)R １１０ｄ , -S(O) ２ R １１０ｄ , -NO ２ , =O, =S, =N(R １１０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｄ ,-SR １１０ｄ , -N(R １１０ｄ ) ２ , -C(O)R １１０ｄ , -C(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)R １１０ｄ , -N(R １１０ｄ ) C(O)N(R １１０ｄ ) ２ , -OC(O)N(R １１０ｄ ) ２ , -N(R １１０ｄ ) C(O)OR １１０ｄ , -C(O)OR １１０ｄ , -OC(O)R １１０ｄ , -S(O)R １１０ｄ , -S(O) ２ R １１０ｄ , -NO ２ , =O, =S, =N(R １１０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｅ Independently: Halogen, -OR １１０ｅ ,-SR １１０ｅ , -N(R １１０ｅ ) ２ , -C(O)R １１０ｅ , -C(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)R １１０ｅ , -N(R １１０ｅ ) C(O)N(R １１０ｅ ) ２ , -OC(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)OR １１０ｅ , -C(O)OR １１０ｅ , -OC(O)R １１０ｅ , -S(O)R １１０ｅ , -S(O) ２ R １１０ｅ , -NO ２ , =O, =S, =N(R １１０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｅ ,-SR １１０ｅ , -N(R １１０ｅ ) ２ , -C(O)R １１０ｅ , -C(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)R １１０ｅ , -N(R １１０ｅ ) C(O)N(R １１０ｅ ) ２ , -OC(O)N(R １１０ｅ ) ２ , -N(R １１０ｅ ) C(O)OR １１０ｅ , -C(O)OR １１０ｅ , -OC(O)R １１０ｅ , -S(O)R １１０ｅ , -S(O) ２ R １１０ｅ , -NO ２ , =O, =S, =N(R １１０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｆ Independently: Halogen, -OR １１０ｆ ,-SR １１０ｆ , -N(R １１０ｆ ) ２ , -C(O)R １１０ｆ , -C(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)R １１０ｆ , -N(R １１０ｆ ) C(O)N(R １１０ｆ ) ２ , -OC(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)OR １１０ｆ , -C(O)OR １１０ｆ , -OC(O)R １１０ｆ , -S(O)R １１０ｆ , -S(O) ２ R １１０ｆ , -NO ２ , =O, =S, =N(R １１０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｆ ,-SR １１０ｆ , -N(R １１０ｆ ) ２ , -C(O)R １１０ｆ , -C(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)R １１０ｆ , -N(R １１０ｆ ) C(O)N(R １１０ｆ ) ２ , -OC(O)N(R １１０ｆ ) ２ , -N(R １１０ｆ ) C(O)OR １１０ｆ , -C(O)OR １１０ｆ , -OC(O)R １１０ｆ , -S(O)R １１０ｆ , -S(O) ２ R １１０ｆ , -NO ２ , =O, =S, =N(R １１０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R １９ｇ Independently: Halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R １１０ａ , R １１０ｂ , R １１０ｃ , R １１０ｄ , R １１０ｅ , R １１０ｆ , R １１０ｇ , R １１０ｚ Independently: Hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; and Here X １４ 1N or N ＋ (-O － ) If R １８ teeth: Hydrogen; -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -C(O)OR １１０ｇ , -S(O)R １１０ｇ , and -S(O) ２ R １１０ｇ ; Halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ ,-CN,C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｇ Each of these is replaced as needed; Halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. ２～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R １９ｇ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｇ ,-SR １１０ｇ , -N(R １１０ｇ ) ２ , -C(O)R １１０ｇ , -C(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)R １１０ｇ , -N(R １１０ｇ ) C(O)N(R １１０ｇ ) ２ , -OC(O)N(R １１０ｇ ) ２ , -N(R １１０ｇ ) C(O)OR １１０ｇ , -C(O)OR １１０ｇ , -OC(O)R １１０ｇ , -S(O)R １１０ｇ , -S(O) ２ R １１０ｇ , -NO ２ , =O, =S, =N(R １１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R １９ｇ Each is replaced as needed. A compound or a salt thereof, selected from the above.

50. The compound or salt according to claim 49, wherein the compound or salt is not compound 301, 302, 303, or any salt thereof.

51. The compound or salt according to any one of claims 49 to 50, wherein m is an integer selected from 1 and 2.

52. X １１ are C(H), C(OH), C(OCH ３ ), and selected from N; or X １２ However, selected from N and C(H); X １３ However, it is selected from C(H); or X １４ A compound or salt according to any one of claims 49 to 51, wherein C(H) is selected.

53. R １１ａ , R １１ｂ , R １１ｃ , and R １１ｄ Each of these is independent of: hydrogen, -OH, and -OCH ３ A compound or salt according to any one of claims 49 to 52, selected from the above.

54. R １Ｚ However, C １ A compound or salt according to any one of claims 49 to 53, selected from alkyl groups.

55. R １Ｃ A compound or salt according to any one of claims 49 to 54, wherein the compound is selected from hydrogen.

56. R １５ But: Selected from hydrogen, and R １６ A compound or salt according to any one of claims 49 to 55, wherein hydrogen is selected.

57. R １７ A compound or salt according to any one of claims 49 to 56, wherein hydrogen is selected.

58. R １８ A compound or salt according to any one of claims 49 to 57, wherein the compound is selected from hydrogen.

59. Each R １９ｂ Independently: Halogen, -CN, -OR １１０ｂ ,-SR １１０ｂ , and -N(R １１０ｂ ) ２ ; Halogen, -OR １１０ｂ ,-SR １１０ｂ , -N(R １１０ｂ ) ２ , = O, -CN, C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ alkyl; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １１０ｂ ,-SR １１０ｂ , -N(R １１０ｂ ) ２ , = O, -CN, C １～６ Substituted as needed with one or more substituents independently selected from alkyl groups. A compound or salt according to any one of claims 49 to 58, selected from the above.

60. Each R １９ｂ A compound or salt according to any one of claims 49 to 59, in which is independently selected from fluoro.

61. Each R １１０ａ , R １１０ｂ , R １１０ｚ , R １１０ｃ , R １１０ｄ , R １１０ｅ , R １１０ｆ , and R １１０ｇ A compound or salt according to any one of claims 49 to 60, wherein the compound is independently selected from hydrogen.

62. X １４ 1N or N ＋ (-O － ) If R １８ A compound or salt according to any one of claims 49 to 61, wherein the compound is selected from hydrogen.

63. R １２ but, 【Chemical 186】 Selected from, here Q １ is halogen, -CN, -OH, -O(C １～６ A compound or salt according to any one of claims 49 to 62, selected from alkyl and -OH.

64. R １２ but, 【Chemistry 187】 A compound or salt according to any one of claims 49 to 63, selected from among them.

65. A compound or salt according to any one of claims 49 to 64, selected from compounds 59, 95, 96, and 141, or a salt of any one thereof.

66. Formula (IIa): 【Chemical 188】 A compound represented by or a salt thereof, wherein in formula (IIa), R ２２ teeth: 【Chemical 189】 Selected from; p is an integer selected from 1, 2, 3, 4, and 5; q is an integer selected from 1, 2, 3, and 4; Each R ２１ Independently: ハロゲン、-NO ２ 、-N ３ 、-CN、-OR ２１０ａ 、-SR ２１０ａ 、-N(R ２１０ａ ) ２ 、-C(O)R ２１０ａ 、-C(O)N(R ２１０ａ ) ２ 、-N(R ２１０ａ )C(O)R ２１０ａ 、-N(R ２１０ａ )C(O)N(R ２１０ａ ) ２ 、-OC(O)N(R ２１０ａ ) ２ 、-N(R ２１０ａ )C(O)OR ２１０ａ 、-C(O)OR ２１０ａ 、-OC(O)R ２１０ａ 、-S(O)R ２１０ａ 、および-S(O) ２ R ２１０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ａ ,-SR ２１０ａ , -N(R ２１０ａ ) ２ , -C(O)R ２１０ａ , -C(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)R ２１０ａ , -C(O)OR ２１０ａ , -OC(O)R ２１０ａ , -N(R ２１０ａ ) C(O)N(R ２１０ａ ) ２ , -OC(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)OR ２１０ａ , -S(O)R ２１０ａ , -S(O) ２ R ２１０ａ , -NO ２ , =O, =S, =N(R ２１０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ａ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ａ ,-SR ２１０ａ , -N(R ２１０ａ ) ２ , -C(O)R ２１０ａ , -C(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)R ２１０ａ , -N(R ２１０ａ ) C(O)N(R ２１０ａ ) ２ , -OC(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)OR ２１０ａ , -C(O)OR ２１０ａ , -OC(O)R ２１０ａ , -S(O)R ２１０ａ , -S(O) ２ R ２１０ａ , -NO ２ , =O, =S, =N(R ２１０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ａ Each is replaced as needed. Selected from; R ２Ｚ teeth: -C(O)R ２１０ｚ , -C(O)N(R ２１０ｚ ) ２ , -C(O)OR ２１０ｚ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ｚ ,-SR ２１０ｚ , -N(R ２１０ｚ ) ２ , -C(O)R ２１０ｚ , -C(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)R ２１０ｚ , -C(O)OR ２１０ｚ , -OC(O)R ２１０ｚ , -N(R ２１０ｚ ) C(O)N(R ２１０ｚ ) ２ , -OC(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)OR ２１０ｚ , -S(O)R ２１０ｚ , -S(O) ２ R ２１０ｚ , -NO ２ , =O, =S, =N(R ２１０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｚ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｚ ,-SR ２１０ｚ , -N(R ２１０ｚ ) ２ , -C(O)R ２１０ｚ , -C(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)R ２１０ｚ , -N(R ２１０ｚ ) C(O)N(R ２１０ｚ ) ２ , -OC(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)OR ２１０ｚ , -C(O)OR ２１０ｚ , -OC(O)R ２１０ｚ , -S(O)R ２１０ｚ , -S(O) ２ R ２１０ｚ , -NO ２ , =O, =S, =N(R ２１０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｚ Each is replaced as needed. Selected from; R ２Ｃ teeth: Hydrogen; -C(O)R ２１０ｃ , -C(O)N(R ２１０ｃ ) ２ , -C(O)OR ２１０ｃ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ｃ ,-SR ２１０ｃ , -N(R ２１０ｃ ) ２ , -C(O)R ２１０ｃ , -C(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)R ２１０ｃ , -C(O)OR ２１０ｃ , -OC(O)R ２１０ｃ , -N(R ２１０ｃ ) C(O)N(R ２１０ｃ ) ２ , -OC(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)OR ２１０ｃ , -S(O)R ２１０ｃ , -S(O) ２ R ２１０ｃ , -NO ２ , =O, =S, =N(R ２１０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｃ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｃ ,-SR ２１０ｃ , -N(R ２１０ｃ ) ２ , -C(O)R ２１０ｃ , -C(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)R ２１０ｃ , -N(R ２１０ｃ ) C(O)N(R ２１０ｃ ) ２ , -OC(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)OR ２１０ｃ , -C(O)OR ２１０ｃ , -OC(O)R ２１０ｃ , -S(O)R ２１０ｃ , -S(O) ２ R ２１０ｃ , -NO ２ , =O, =S, =N(R ２１０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｃ Each is replaced as needed. Selected from; R ２５ teeth: Hydrogen; halogen, -OR ２１０ｄ ,-SR ２１０ｄ , -N(R ２１０ｄ ) ２ , -C(O)R ２１０ｄ , -C(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)R ２１０ｄ , -C(O)OR ２１０ｄ , -OC(O)R ２１０ｄ , -N(R ２１０ｄ ) C(O)N(R ２１０ｄ ) ２ , -OC(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)OR ２１０ｄ , -S(O)R ２１０ｄ , -S(O) ２ R ２１０ｄ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ｄ ,-SR ２１０ｄ , -N(R ２１０ｄ ) ２ , -C(O)R ２１０ｄ , -C(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)R ２１０ｄ , -C(O)OR ２１０ｄ , -OC(O)R ２１０ｄ , -N(R ２１０ｄ ) C(O)N(R ２１０ｄ ) ２ , -OC(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)OR ２１０ｄ , -S(O)R ２１０ｄ , -S(O) ２ R ２１０ｄ , -NO ２ , =O, =S, =N(R ２１０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｄ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｄ ,-SR ２１０ｄ , -N(R ２１０ｄ ) ２ , -C(O)R ２１０ｄ , -C(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)R ２１０ｄ , -N(R ２１０ｄ ) C(O)N(R ２１０ｄ ) ２ , -OC(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)OR ２１０ｄ , -C(O)OR ２１０ｄ , -OC(O)R ２１０ｄ , -S(O)R ２１０ｄ , -S(O) ２ R ２１０ｄ , -NO ２ , =O, =S, =N(R ２１０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｄ Each is replaced as needed. Selected from; or R ２５ is R ２６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ A carbon ring has one or more R ２９ｄ It is replaced as needed; R ２６ teeth: Hydrogen; halogen, -OR ２１０ｅ ,-SR ２１０ｅ , -N(R ２１０ｅ ) ２ , -C(O)R ２１０ｅ , -C(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)R ２１０ｅ , -C(O)OR ２１０ｅ , -OC(O)R ２１０ｅ , -N(R ２１０ｅ ) C(O)N(R ２１０ｅ ) ２ , -OC(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)OR ２１０ｅ , -S(O)R ２１０ｅ , -S(O) ２ R ２１０ｅ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ｅ ,-SR ２１０ｅ , -N(R ２１０ｅ ) ２ , -C(O)R ２１０ｅ , -C(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)R ２１０ｅ , -C(O)OR ２１０ｅ , -OC(O)R ２１０ｅ , -N(R ２１０ｅ ) C(O)N(R ２１０ｅ ) ２ , -OC(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)OR ２１０ｅ , -S(O)R ２１０ｅ , -S(O) ２ R ２１０ｅ , -NO ２ , =O, =S, =N(R ２１０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｅ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｅ ,-SR ２１０ｅ , -N(R ２１０ｅ ) ２ , -C(O)R ２１０ｅ , -C(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)R ２１０ｅ , -N(R ２１０ｅ ) C(O)N(R ２１０ｅ ) ２ , -OC(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)OR ２１０ｅ , -C(O)OR ２１０ｅ , -OC(O)R ２１０ｅ , -S(O)R ２１０ｅ , -S(O) ２ R ２１０ｅ , -NO ２ , =O, =S, =N(R ２１０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｅ Each is replaced as needed. Selected from; or R ２６ is R ２５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ A carbon ring has one or more R ２９ｅ It is replaced as needed; R ２７ teeth: Hydrogen; -C(O)R ２１０ｆ , -C(O)N(R ２１０ｆ ) ２ , -C(O)OR ２１０ｆ , -S(O)R ２１０ｆ , and -S(O) ２ R ２１０ｆ ; Halogen, -OR ２１０ｆ ,-SR ２１０ｆ , -N(R ２１０ｆ ) ２ , -C(O)R ２１０ｆ , -C(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)R ２１０ｆ , -C(O)OR ２１０ｆ , -OC(O)R ２１０ｆ , -N(R ２１０ｆ ) C(O)N(R ２１０ｆ ) ２ , -OC(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)OR ２１０ｆ , -S(O)R ２１０ｆ , -S(O) ２ R ２１０ｆ , -NO ２ , =O, =S, =N(R ２１０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｆ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｆ ,-SR ２１０ｆ , -N(R ２１０ｆ ) ２ , -C(O)R ２１０ｆ , -C(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)R ２１０ｆ , -N(R ２１０ｆ ) C(O)N(R ２１０ｆ ) ２ , -OC(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)OR ２１０ｆ , -C(O)OR ２１０ｆ , -OC(O)R ２１０ｆ , -S(O)R ２１０ｆ , -S(O) ２ R ２１０ｆ , -NO ２ , =O, =S, =N(R ２１０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｆ Each is replaced as needed. Selected from; R ２８ teeth: Hydrogen; -C(O)R ２１０ｇ , -C(O)N(R ２１０ｇ ) ２ , -C(O)OR ２１０ｇ , -S(O)R ２１０ｇ , and -S(O) ２ R ２１０ｇ ; Halogen, -OR ２１０ｇ ,-SR ２１０ｇ , -N(R ２１０ｇ ) ２ , -C(O)R ２１０ｇ , -C(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)R ２１０ｇ , -C(O)OR ２１０ｇ , -OC(O)R ２１０ｇ , -N(R ２１０ｇ ) C(O)N(R ２１０ｇ ) ２ , -OC(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)OR ２１０ｇ , -S(O)R ２１０ｇ , -S(O) ２ R ２１０ｇ , -NO ２ , =O, =S, =N(R ２１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ２９ｇ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｇ ,-SR ２１０ｇ , -N(R ２１０ｇ ) ２ , -C(O)R ２１０ｇ , -C(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)R ２１０ｇ , -N(R ２１０ｇ ) C(O)N(R ２１０ｇ ) ２ , -OC(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)OR ２１０ｇ , -C(O)OR ２１０ｇ , -OC(O)R ２１０ｇ , -S(O)R ２１０ｇ , -S(O) ２ R ２１０ｇ , -NO ２ , =O, =S, =N(R ２１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl has one or more R ２９ｇ Each is replaced as needed. Selected from; Each R ２９ａ Independently: Halogen, -OR ２１０ａ ,-SR ２１０ａ , -N(R ２１０ａ ) ２ , -C(O)R ２１０ａ , -C(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)R ２１０ａ , -N(R ２１０ａ ) C(O)N(R ２１０ａ ) ２ , -OC(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)OR ２１０ａ , -C(O)OR ２１０ａ , -OC(O)R ２１０ａ , -S(O)R ２１０ａ , -S(O) ２ R ２１０ａ , -NO ２ , =O, =S, =N(R ２１０ａ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ａ ,-SR ２１０ａ , -N(R ２１０ａ ) ２ , -C(O)R ２１０ａ , -C(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)R ２１０ａ , -N(R ２１０ａ ) C(O)N(R ２１０ａ ) ２ , -OC(O)N(R ２１０ａ ) ２ , -N(R ２１０ａ ) C(O)OR ２１０ａ , -C(O)OR ２１０ａ , -OC(O)R ２１０ａ , -S(O)R ２１０ａ , -S(O) ２ R ２１０ａ , -NO ２ , =O, =S, =N(R ２１０ａ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｂ Independently: ハロゲン、-NO ２ 、-N ３ 、-CN、-OR ２１０ｂ 、-SR ２１０ｂ 、-N(R ２１０ｂ ) ２ 、-C(O)R ２１０ｂ 、-C(O)N(R ２１０ｂ ) ２ 、-N(R ２１０ｂ )C(O)R ２１０ｂ 、-N(R ２１０ｂ )C(O)N(R ２１０ｂ ) ２ 、-OC(O)N(R ２１０ｂ ) ２ 、-N(R ２１０ｂ )C(O)OR ２１０ｂ 、-C(O)OR ２１０ｂ 、-OC(O)R ２１０ｂ 、-S(O)R ２１０ｂ 、および-S(O) ２ R ２１０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ２１０ｂ ,-SR ２１０ｂ , -N(R ２１０ｂ ) ２ , -C(O)R ２１０ｂ , -C(O)N(R ２１０ｂ ) ２ , -N(R ２１０ｂ ) C(O)R ２１０ｂ , -C(O)OR ２１０ｂ , -OC(O)R ２１０ｂ , -N(R ２１０ｂ ) C(O)N(R ２１０ｂ ) ２ , -OC(O)N(R ２１０ｂ ) ２ , -N(R ２１０ｂ ) C(O)OR ２１０ｂ , -S(O)R ２１０ｂ , -S(O) ２ R ２１０ｂ , -NO ２ , =O, =S, =N(R ２１０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ２１０ｂ ,-SR ２１０ｂ , -N(R ２１０ｂ ) ２ , -C(O)R ２１０ｂ , -C(O)N(R ２１０ｂ ) ２ , -N(R ２１０ｂ ) C(O)R ２１０ｂ , -N(R ２１０ｂ ) C(O)N(R ２１０ｂ ) ２ , -OC(O)N(R ２１０ｂ ) ２ , -N(R ２１０ｂ ) C(O)OR ２１０ｂ , -C(O)OR ２１０ｂ , -OC(O)R ２１０ｂ , -S(O)R ２１０ｂ , -S(O) ２ R ２１０ｂ , -NO ２ , =O, =S, =N(R ２１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R ２９ｃ Independently: Halogen, -OR ２１０ｃ ,-SR ２１０ｃ , -N(R ２１０ｃ ) ２ , -C(O)R ２１０ｃ , -C(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)R ２１０ｃ , -N(R ２１０ｃ ) C(O)N(R ２１０ｃ ) ２ , -OC(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)OR ２１０ｃ , -C(O)OR ２１０ｃ , -OC(O)R ２１０ｃ , -S(O)R ２１０ｃ , -S(O) ２ R ２１０ｃ , -NO ２ , =O, =S, =N(R ２１０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｃ ,-SR ２１０ｃ , -N(R ２１０ｃ ) ２ , -C(O)R ２１０ｃ , -C(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)R ２１０ｃ , -N(R ２１０ｃ ) C(O)N(R ２１０ｃ ) ２ , -OC(O)N(R ２１０ｃ ) ２ , -N(R ２１０ｃ ) C(O)OR ２１０ｃ , -C(O)OR ２１０ｃ , -OC(O)R ２１０ｃ , -S(O)R ２１０ｃ , -S(O) ２ R ２１０ｃ , -NO ２ , =O, =S, =N(R ２１０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｄ Independently: Halogen, -OR ２１０ｄ ,-SR ２１０ｄ , -N(R ２１０ｄ ) ２ , -C(O)R ２１０ｄ , -C(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)R ２１０ｄ , -N(R ２１０ｄ ) C(O)N(R ２１０ｄ ) ２ , -OC(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)OR ２１０ｄ , -C(O)OR ２１０ｄ , -OC(O)R ２１０ｄ , -S(O)R ２１０ｄ , -S(O) ２ R ２１０ｄ , -NO ２ , =O, =S, =N(R ２１０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｄ ,-SR ２１０ｄ , -N(R ２１０ｄ ) ２ , -C(O)R ２１０ｄ , -C(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)R ２１０ｄ , -N(R ２１０ｄ ) C(O)N(R ２１０ｄ ) ２ , -OC(O)N(R ２１０ｄ ) ２ , -N(R ２１０ｄ ) C(O)OR ２１０ｄ , -C(O)OR ２１０ｄ , -OC(O)R ２１０ｄ , -S(O)R ２１０ｄ , -S(O) ２ R ２１０ｄ , -NO ２ , =O, =S, =N(R ２１０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｅ Independently: Halogen, -OR ２１０ｅ ,-SR ２１０ｅ , -N(R ２１０ｅ ) ２ , -C(O)R ２１０ｅ , -C(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)R ２１０ｅ , -N(R ２１０ｅ ) C(O)N(R ２１０ｅ ) ２ , -OC(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)OR ２１０ｅ , -C(O)OR ２１０ｅ , -OC(O)R ２１０ｅ , -S(O)R ２１０ｅ , -S(O) ２ R ２１０ｅ , -NO ２ , =O, =S, =N(R ２１０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｅ ,-SR ２１０ｅ , -N(R ２１０ｅ ) ２ , -C(O)R ２１０ｅ , -C(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)R ２１０ｅ , -N(R ２１０ｅ ) C(O)N(R ２１０ｅ ) ２ , -OC(O)N(R ２１０ｅ ) ２ , -N(R ２１０ｅ ) C(O)OR ２１０ｅ , -C(O)OR ２１０ｅ , -OC(O)R ２１０ｅ , -S(O)R ２１０ｅ , -S(O) ２ R ２１０ｅ , -NO ２ , =O, =S, =N(R ２１０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｆ Independently: Halogen, -OR ２１０ｆ ,-SR ２１０ｆ , -N(R ２１０ｆ ) ２ , -C(O)R ２１０ｆ , -C(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)R ２１０ｆ , -N(R ２１０ｆ ) C(O)N(R ２１０ｆ ) ２ , -OC(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)OR ２１０ｆ , -C(O)OR ２１０ｆ , -OC(O)R ２１０ｆ , -S(O)R ２１０ｆ , -S(O) ２ R ２１０ｆ , -NO ２ , =O, =S, =N(R ２１０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｆ ,-SR ２１０ｆ , -N(R ２１０ｆ ) ２ , -C(O)R ２１０ｆ , -C(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)R ２１０ｆ , -N(R ２１０ｆ ) C(O)N(R ２１０ｆ ) ２ , -OC(O)N(R ２１０ｆ ) ２ , -N(R ２１０ｆ ) C(O)OR ２１０ｆ , -C(O)OR ２１０ｆ , -OC(O)R ２１０ｆ , -S(O)R ２１０ｆ , -S(O) ２ R ２１０ｆ , -NO ２ , =O, =S, =N(R ２１０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｇ Independently: Halogen, -OR ２１０ｇ ,-SR ２１０ｇ , -N(R ２１０ｇ ) ２ , -C(O)R ２１０ｇ , -C(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)R ２１０ｇ , -N(R ２１０ｇ ) C(O)N(R ２１０ｇ ) ２ , -OC(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)OR ２１０ｇ , -C(O)OR ２１０ｇ , -OC(O)R ２１０ｇ , -S(O)R ２１０ｇ , -S(O) ２ R ２１０ｇ , -NO ２ , =O, =S, =N(R ２１０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｇ ,-SR ２１０ｇ , -N(R ２１０ｇ ) ２ , -C(O)R ２１０ｇ , -C(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)R ２１０ｇ , -N(R ２１０ｇ ) C(O)N(R ２１０ｇ ) ２ , -OC(O)N(R ２１０ｇ ) ２ , -N(R ２１０ｇ ) C(O)OR ２１０ｇ , -C(O)OR ２１０ｇ , -OC(O)R ２１０ｇ , -S(O)R ２１０ｇ , -S(O) ２ R ２１０ｇ , -NO ２ , =O, =S, =N(R ２１０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ２９ｚ Independently: Halogen, -OR ２１０ｚ ,-SR ２１０ｚ , -N(R ２１０ｚ ) ２ , -C(O)R ２１０ｚ , -C(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)R ２１０ｚ , -N(R ２１０ｚ ) C(O)N(R ２１０ｚ ) ２ , -OC(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)OR ２１０ｚ , -C(O)OR ２１０ｚ , -OC(O)R ２１０ｚ , -S(O)R ２１０ｚ , -S(O) ２ R ２１０ｚ , -NO ２ , =O, =S, =N(R ２１０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ２１０ｚ ,-SR ２１０ｚ , -N(R ２１０ｚ ) ２ , -C(O)R ２１０ｚ , -C(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)R ２１０ｚ , -N(R ２１０ｚ ) C(O)N(R ２１０ｚ ) ２ , -OC(O)N(R ２１０ｚ ) ２ , -N(R ２１０ｚ ) C(O)OR ２１０ｚ , -C(O)OR ２１０ｚ , -OC(O)R ２１０ｚ , -S(O)R ２１０ｚ , -S(O) ２ R ２１０ｚ , -NO ２ , =O, =S, =N(R ２１０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R ２１０ａ , R ２１０ｂ , R ２１０ｃ , R ２１０ｄ , R ２１０ｅ , R ２１０ｆ , R ２１０ｇ , and R ２１０ｚ Independently: Hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. A compound or a salt thereof, selected from the above.

67. The compound or salt according to claim 66, wherein the compound is not compound 136, 142, 143, 154, 155, 401, 405, 406, 407, 408, or a salt of any of these.

68. The compound or salt according to claim 66 or claim 67, wherein p is an integer selected from 1 and 2, or q is an integer selected from 1 and 2.

69. Each R ２１ These are independent: halogen, -CN, -OR ２１０ａ , as well as C, optionally substituted with one or more substituents independently selected from fluoro and -CN １～６ A compound or salt according to any one of claims 66 to 68, selected from alkyl groups.

70. Each R ２１ These independently form: fluoro, chloro, -OH, -O(CH ３ ), -CF ３ , and C １ A compound or salt according to any one of claims 66 to 69, selected from alkyl groups.

71. R ２Ｚ However, C １ A compound or salt according to any one of claims 66 to 70, selected from alkyl groups.

72. R ２Ｃ a: A compound or salt according to any one of claims 66 to 71, selected from hydrogen.

73. R ２５ is hydrogen, and R ２６ A compound or salt according to any one of claims 66 to 72, wherein is hydrogen.

74. R ２７ A compound or salt according to any one of claims 66 to 73, wherein hydrogen is selected.

75. R ２２ but, 【Chemistry 190】 A compound or salt according to any one of claims 66 to 74, selected from the above.

76. R ２８ a: A compound or salt according to any one of claims 66 to 75, selected from hydrogen.

77. Each R ２１０ａ , R ２１０ｂ , R ２１０ｚ , R ２１０ｃ , R ２１０ｄ , R ２１０ｅ , R ２１０ｆ , and R ２１０ｇ A compound or salt according to any one of claims 66 to 76, wherein the compound is independently selected from hydrogen.

78. A compound or salt according to any one of claims 66 to 77, selected from compounds 72, 39, 104, 36, 35, 38, 40, 51, 37, 41, 34, 33, 402, 403, and 404, or a salt of any one of these.

79. Equation (IIb): 【Chemistry 191】 A compound or salt thereof represented by formula (IIb): R ３２ teeth, 【Chemistry 192】 Selected from; s is an integer selected from 2, 3, 4, and 5; R ３Ｚ teeth: -C(O)R ３１０ｚ , -C(O)N(R ３１０ｚ ) ２ , -C(O)OR ３１０ｚ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｚ ,-SR ３１０ｚ , -N(R ３１０ｚ ) ２ , -C(O)R ３１０ｚ , -C(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)R ３１０ｚ , -C(O)OR ３１０ｚ , -OC(O)R ３１０ｚ , -N(R ３１０ｚ ) C(O)N(R ３１０ｚ ) ２ , -OC(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)OR ３１０ｚ , -S(O)R ３１０ｚ , -S(O) ２ R ３１０ｚ , -NO ２ , =O, =S, =N(R ３１０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｚ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｚ ,-SR ３１０ｚ , -N(R ３１０ｚ ) ２ , -C(O)R ３１０ｚ , -C(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)R ３１０ｚ , -N(R ３１０ｚ ) C(O)N(R ３１０ｚ ) ２ , -OC(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)OR ３１０ｚ , -C(O)OR ３１０ｚ , -OC(O)R ３１０ｚ , -S(O)R ３１０ｚ , -S(O) ２ R ３１０ｚ , -NO ２ , = S, = N (R ３１０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｚ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ３Ｃ teeth: hydrogen; -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -C(O)OR ３１０ｃ , and -CN; Halogen, -OR ３１０ｃ ,-SR ３１０ｃ , -N(R ３１０ｃ ) ２ , -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)R ３１０ｃ , -C(O)OR ３１０ｃ , -OC(O)R ３１０ｃ , -N(R ３１０ｃ ) C(O)N(R ３１０ｃ ) ２ , -OC(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)OR ３１０ｃ , -S(O)R ３１０ｃ , -S(O) ２ R ３１０ｃ , -NO ２ , = S, = N (R ３１０ｃ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～２ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｃ Each of which is substituted as necessary by one or more substituents independently selected from, C ３～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｃ ,-SR ３１０ｃ , -N(R ３１０ｃ ) ２ , -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)R ３１０ｃ , -C(O)OR ３１０ｃ , -OC(O)R ３１０ｃ , -N(R ３１０ｃ ) C(O)N(R ３１０ｃ ) ２ , -OC(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)OR ３１０ｃ , -S(O)R ３１０ｃ , -S(O) ２ R ３１０ｃ , -NO ２ , =O, =S, =N(R ３１０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ３９ｃ Those which are replaced as needed; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｃ ,-SR ３１０ｃ , -N(R ３１０ｃ ) ２ , -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)R ３１０ｃ , -N(R ３１０ｃ ) C(O)N(R ３１０ｃ ) ２ , -OC(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)OR ３１０ｃ , -C(O)OR ３１０ｃ , -OC(O)R ３１０ｃ , -S(O)R ３１０ｃ , -S(O) ２ R ３１０ｃ , -NO ２ , =O, =S, =N(R ３１０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｃ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ３５ teeth: Hydrogen; halogen, -OR ３１０ｄ ,-SR ３１０ｄ , -N(R ３１０ｄ ) ２ , -C(O)R ３１０ｄ , -C(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)R ３１０ｄ , -C(O)OR ３１０ｄ , -OC(O)R ３１０ｄ , -N(R ３１０ｄ ) C(O)N(R ３１０ｄ ) ２ , -OC(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)OR ３１０ｄ , -S(O)R ３１０ｄ , -S(O) ２ R ３１０ｄ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｄ ,-SR ３１０ｄ , -N(R ３１０ｄ ) ２ , -C(O)R ３１０ｄ , -C(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)R ３１０ｄ , -C(O)OR ３１０ｄ , -OC(O)R ３１０ｄ , -N(R ３１０ｄ ) C(O)N(R ３１０ｄ ) ２ , -OC(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)OR ３１０ｄ , -S(O)R ３１０ｄ , -S(O) ２ R ３１０ｄ , -NO ２ , =O, =S, =N(R ３１０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｄ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｄ ,-SR ３１０ｄ , -N(R ３１０ｄ ) ２ , -C(O)R ３１０ｄ , -C(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)R ３１０ｄ , -N(R ３１０ｄ ) C(O)N(R ３１０ｄ ) ２ , -OC(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)OR ３１０ｄ , -C(O)OR ３１０ｄ , -OC(O)R ３１０ｄ , -S(O)R ３１０ｄ , -S(O) ２ R ３１０ｄ , -NO ２ , =O, =S, =N(R ３１０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｄ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ３５ is R ３６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ３９ｄ It is optionally substituted with one or more substituents selected independently of it; R ３６ teeth: Hydrogen; halogen, -OR ３１０ｅ ,-SR ３１０ｅ , -N(R ３１０ｅ ) ２ , -C(O)R ３１０ｅ , -C(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)R ３１０ｅ , -C(O)OR ３１０ｅ , -OC(O)R ３１０ｅ , -N(R ３１０ｅ ) C(O)N(R ３１０ｅ ) ２ , -OC(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)OR ３１０ｅ , -S(O)R ３１０ｅ , -S(O) ２ R ３１０ｅ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｅ ,-SR ３１０ｅ , -N(R ３１０ｅ ) ２ , -C(O)R ３１０ｅ , -C(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)R ３１０ｅ , -C(O)OR ３１０ｅ , -OC(O)R ３１０ｅ , -N(R ３１０ｅ ) C(O)N(R ３１０ｅ ) ２ , -OC(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)OR ３１０ｅ , -S(O)R ３１０ｅ , -S(O) ２ R ３１０ｅ , -NO ２ , =O, =S, =N(R ３１０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｅ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｅ ,-SR ３１０ｅ , -N(R ３１０ｅ ) ２ , -C(O)R ３１０ｅ , -C(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)R ３１０ｅ , -N(R ３１０ｅ ) C(O)N(R ３１０ｅ ) ２ , -OC(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)OR ３１０ｅ , -C(O)OR ３１０ｅ , -OC(O)R ３１０ｅ , -S(O)R ３１０ｅ , -S(O) ２ R ３１０ｅ , -NO ２ , =O, =S, =N(R ３１０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｅ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ３６ is R ３５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ３９ｅ It is optionally substituted with one or more substituents selected independently of it; R ３７ teeth: Hydrogen; -C(O)R ３１０ｆ , -C(O)N(R ３１０ｆ ) ２ , -C(O)OR ３１０ｆ , -S(O)R ３１０ｆ , and -S(O) ２ R ３１０ｆ ; Halogen, -OR ３１０ｆ ,-SR ３１０ｆ , -N(R ３１０ｆ ) ２ , -C(O)R ３１０ｆ , -C(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)R ３１０ｆ , -C(O)OR ３１０ｆ , -OC(O)R ３１０ｆ , -N(R ３１０ｆ ) C(O)N(R ３１０ｆ ) ２ , -OC(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)OR ３１０ｆ , -S(O)R ３１０ｆ , -S(O) ２ R ３１０ｆ , -NO ２ , =O, =S, =N(R ３１０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｆ ,-SR ３１０ｆ , -N(R ３１０ｆ ) ２ , -C(O)R ３１０ｆ , -C(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)R ３１０ｆ , -N(R ３１０ｆ ) C(O)N(R ３１０ｆ ) ２ , -OC(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)OR ３１０ｆ , -C(O)OR ３１０ｆ , -OC(O)R ３１０ｆ , -S(O)R ３１０ｆ , -S(O) ２ R ３１０ｆ , -NO ２ , =O, =S, =N(R ３１０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ３８ teeth: Hydrogen; -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -C(O)OR ３１０ｇ , -S(O)R ３１０ｇ , and -S(O) ２ R ３１０ｇ ; Halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｇ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｇ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R ３９ｚ Independently: Halogen, -OR ３１０ｚ ,-SR ３１０ｚ , -N(R ３１０ｚ ) ２ , -C(O)R ３１０ｚ , -C(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)R ３１０ｚ , -N(R ３１０ｚ ) C(O)N(R ３１０ｚ ) ２ , -OC(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)OR ３１０ｚ , -C(O)OR ３１０ｚ , -OC(O)R ３１０ｚ , -S(O)R ３１０ｚ , -S(O) ２ R ３１０ｚ , -NO ２ , =O, =S, =N(R ３１０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｚ ,-SR ３１０ｚ , -N(R ３１０ｚ ) ２ , -C(O)R ３１０ｚ , -C(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)R ３１０ｚ , -N(R ３１０ｚ ) C(O)N(R ３１０ｚ ) ２ , -OC(O)N(R ３１０ｚ ) ２ , -N(R ３１０ｚ ) C(O)OR ３１０ｚ , -C(O)OR ３１０ｚ , -OC(O)R ３１０ｚ , -S(O)R ３１０ｚ , -S(O) ２ R ３１０ｚ , -NO ２ , =O, =S, =N(R ３１０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ３９ｂ Independently: Halogen, -NO ２ , -N ３ -CN, -O(C ４～６ Alkyl), -O (C １～６ Haloalkyl), -SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , and -S(O) ２ R ３１０ｂ ; Halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , -CN, and C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , and those which are optionally substituted with one or more substituents independently selected from -CN; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R ３９ｃ Independently: Halogen, -OR ３１０ｃ ,-SR ３１０ｃ , -N(R ３１０ｃ ) ２ , -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)R ３１０ｃ , -N(R ３１０ｃ ) C(O)N(R ３１０ｃ ) ２ , -OC(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)OR ３１０ｃ , -C(O)OR ３１０ｃ , -OC(O)R ３１０ｃ , -S(O)R ３１０ｃ , -S(O) ２ R ３１０ｃ , -NO ２ , =O, =S, =N(R ３１０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｃ ,-SR ３１０ｃ , -N(R ３１０ｃ ) ２ , -C(O)R ３１０ｃ , -C(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)R ３１０ｃ , -N(R ３１０ｃ ) C(O)N(R ３１０ｃ ) ２ , -OC(O)N(R ３１０ｃ ) ２ , -N(R ３１０ｃ ) C(O)OR ３１０ｃ , -C(O)OR ３１０ｃ , -OC(O)R ３１０ｃ , -S(O)R ３１０ｃ , -S(O) ２ R ３１０ｃ , -NO ２ , =O, =S, =N(R ３１０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ３９ｄ Independently: Halogen, -OR ３１０ｄ ,-SR ３１０ｄ , -N(R ３１０ｄ ) ２ , -C(O)R ３１０ｄ , -C(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)R ３１０ｄ , -N(R ３１０ｄ ) C(O)N(R ３１０ｄ ) ２ , -OC(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)OR ３１０ｄ , -C(O)OR ３１０ｄ , -OC(O)R ３１０ｄ , -S(O)R ３１０ｄ , -S(O) ２ R ３１０ｄ , -NO ２ , =O, =S, =N(R ３１０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｄ ,-SR ３１０ｄ , -N(R ３１０ｄ ) ２ , -C(O)R ３１０ｄ , -C(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)R ３１０ｄ , -N(R ３１０ｄ ) C(O)N(R ３１０ｄ ) ２ , -OC(O)N(R ３１０ｄ ) ２ , -N(R ３１０ｄ ) C(O)OR ３１０ｄ , -C(O)OR ３１０ｄ , -OC(O)R ３１０ｄ , -S(O)R ３１０ｄ , -S(O) ２ R ３１０ｄ , -NO ２ , =O, =S, =N(R ３１０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ３９ｅ Independently: Halogen, -OR ３１０ｅ ,-SR ３１０ｅ , -N(R ３１０ｅ ) ２ , -C(O)R ３１０ｅ , -C(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)R ３１０ｅ , -N(R ３１０ｅ ) C(O)N(R ３１０ｅ ) ２ , -OC(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)OR ３１０ｅ , -C(O)OR ３１０ｅ , -OC(O)R ３１０ｅ , -S(O)R ３１０ｅ , -S(O) ２ R ３１０ｅ , -NO ２ , =O, =S, =N(R ３１０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｅ ,-SR ３１０ｅ , -N(R ３１０ｅ ) ２ , -C(O)R ３１０ｅ , -C(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)R ３１０ｅ , -N(R ３１０ｅ ) C(O)N(R ３１０ｅ ) ２ , -OC(O)N(R ３１０ｅ ) ２ , -N(R ３１０ｅ ) C(O)OR ３１０ｅ , -C(O)OR ３１０ｅ , -OC(O)R ３１０ｅ , -S(O)R ３１０ｅ , -S(O) ２ R ３１０ｅ , -NO ２ , =O, =S, =N(R ３１０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ３９ｆ Independently: Halogen, -OR ３１０ｆ ,-SR ３１０ｆ , -N(R ３１０ｆ ) ２ , -C(O)R ３１０ｆ , -C(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)R ３１０ｆ , -N(R ３１０ｆ ) C(O)N(R ３１０ｆ ) ２ , -OC(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)OR ３１０ｆ , -C(O)OR ３１０ｆ , -OC(O)R ３１０ｆ , -S(O)R ３１０ｆ , -S(O) ２ R ３１０ｆ , -NO ２ , =O, =S, =N(R ３１０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｆ ,-SR ３１０ｆ , -N(R ３１０ｆ ) ２ , -C(O)R ３１０ｆ , -C(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)R ３１０ｆ , -N(R ３１０ｆ ) C(O)N(R ３１０ｆ ) ２ , -OC(O)N(R ３１０ｆ ) ２ , -N(R ３１０ｆ ) C(O)OR ３１０ｆ , -C(O)OR ３１０ｆ , -OC(O)R ３１０ｆ , -S(O)R ３１０ｆ , -S(O) ２ R ３１０ｆ , -NO ２ , =O, =S, =N(R ３１０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ３９ｇ Independently: Halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R ３１０ｚ , R ３１０ｂ , R ３１０ｃ , R ３１０ｄ , R ３１０ｅ , R ３１０ｆ , and R ３１０ｇ Independently: Hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; If s is 3 here, then each R ３９ｂ Independently: Fluoro, bromo, iodine, -NO ２ , -N ３ -CN, -O(C ４～６ Alkyl), -O (C １～６ Haloalkyl), -SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , and -S(O) ２ R ３１０ｂ ; Halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , -CN, and C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , and those which are optionally substituted with one or more substituents independently selected from -CN; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Here R ３７ ga-CH ３ If R ３２ teeth, 【Chemistry 193】 Selected from, where J is: Halogen, -NO ２ , -N ３ -CN, -O(C ４～６ Alkyl), -O (C １～６ Haloalkyl), -SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , and -S(O) ２ R ３１０ｂ ; Halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , -CN, and C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , and those which are optionally substituted with one or more substituents independently selected from -CN; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Here R ３２ but 【Chemistry 194】 And R ３７ H is H, and R ３５ H is H, and R ３６ If H; R ３８ teeth: -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -C(O)OR ３１０ｇ , -S(O)R ３１０ｇ , and -S(O) ２ R ３１０ｇ ; Halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ３９ｇ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｇ ,-SR ３１０ｇ , -N(R ３１０ｇ ) ２ , -C(O)R ３１０ｇ , -C(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)R ３１０ｇ , -N(R ３１０ｇ ) C(O)N(R ３１０ｇ ) ２ , -OC(O)N(R ３１０ｇ ) ２ , -N(R ３１０ｇ ) C(O)OR ３１０ｇ , -C(O)OR ３１０ｇ , -OC(O)R ３１０ｇ , -S(O)R ３１０ｇ , -S(O) ２ R ３１０ｇ , -NO ２ , =O, =S, =N(R ３１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ３９ｇ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; and s is 2, and one R ３９ｂ but 【Chemistry 195】 If so; further R ３９ｂ Each of these is independent: Chloro, bromo, iodine, -NO ２ , -N ３ -CN, -O(C ４～６ Alkyl), -O (C １～６ Haloalkyl), -SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , and -S(O) ２ R ３１０ｂ ; Halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , -CN, and C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ , and those which are optionally substituted with one or more substituents independently selected from -CN; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ３１０ｂ ,-SR ３１０ｂ , -N(R ３１０ｂ ) ２ , -C(O)R ３１０ｂ , -C(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)R ３１０ｂ , -N(R ３１０ｂ ) C(O)N(R ３１０ｂ ) ２ , -OC(O)N(R ３１０ｂ ) ２ , -N(R ３１０ｂ ) C(O)OR ３１０ｂ , -C(O)OR ３１０ｂ , -OC(O)R ３１０ｂ , -S(O)R ３１０ｂ , -S(O) ２ R ３１０ｂ , -NO ２ , =O, =S, =N(R ３１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. A compound or a salt thereof, selected from the above.

80. The compound or salt according to claim 79, wherein the compound or salt is not 166, 167, 169, 503, 505, 514, 515, 516, 517, 518, 519, 520, 521, 522, 523, 524, 525, 526, 527, 528, 529, 530, 533, 534, or any salt thereof.

81. (i) R ３７ ga-CH ３ If R ２ teeth, 【Chemistry 196】 Selected from, where J is selected from fluoro; and (ii)s is 3; each R ３９ｂ The compound or salt according to any one of claims 79 to 80, wherein is independently selected from fluoro and -CN.

82. R ３Ｚ a: A compound or salt according to any one of claims 79 to 81, selected from methyl.

83. R ３Ｃ A: A compound or salt according to any one of claims 79 to 82, selected from hydrogen.

84. R ３７ A compound or salt according to any one of claims 79 to 83, wherein hydrogen is selected.

85. R ３２ but, 【Chemistry 197】 A compound or salt according to any one of claims 79 to 84, selected from the above.

86. R ３８ a: A compound or salt according to any one of claims 79 to 85, selected from hydrogen.

87. Each R ３９ｂ A compound or salt according to any one of claims 79 to 86, wherein the compound is independently selected from fluoro and -CN.

88. A compound or salt according to any one of claims 79 to 87, selected from compounds 31, 32, 42, 50, 87, 101, 102, 501, 502, 504, 506, 507, 508, 509, 510, 511, 512, and 513, or a salt of any one of these.

89. Formula (Ic): 【Chemistry 198】 A compound or salt thereof represented by formula (Ic): R ４２ teeth: 【Chemistry 199】 Selected from; each 【Chemistry 200】 These are independently selected from single and double bonds; X ４１ C(R) ４１ａ ), N, and N ＋ (-O － ) are selected from; X ４２ C(R) ４１ｂ ), N, and N ＋ (-O － ) are selected from; X ４３ C(R) ４１ｃ ), N, and N ＋ (-O － ) are selected from; X ４４ C(R) ４１ｄ ), N, and N ＋ (-O － ) are selected from; Here X ４１ , X ４２ , X ４３ , and X ４４ Two or fewer of these are N or N ＋ (-O － ) and; Y ４１ is C, C(R ４９ｂＡ ), and selected from N; Y ４２ C(R) ４９ｂＢ ), C (R ４９ｂＢ ) ２ , N, N ＋ (-O － ), N (R ４９ｂＢ ), O, S, S(O), and S(O) ２ Selected from; Y ４３ C(R) ４９ｂＣ ), C (R ４９ｂＣ ) ２ , N, N ＋ (-O － ), N (R ４９ｂＣ ), O, S, S(O), and S(O) ２ Selected from; Y ４４ C(R) ４９ｂＤ ), C (R ４９ｂＤ ) ２ , N, N ＋ (-O － ), N (R ４９ｂＤ ), O, S, S(O), and S(O) ２ Selected from; Y ４５ C(R) ４９ｂＥ ), C (R ４９ｂＥ ) ２ , N, N ＋ (-O － ), N (R ４９ｂＥ ), O, S, S(O), and S(O) ２ Selected from; Here Y ４１ , Y ４２ , Y ４３ , Y ４４ , and Y ４５ Three or fewer of these are N or N ＋ (-O － ) and; R ４１ａ , R ４１ｂ , R ４１ｃ , and R ４１ｄ Each is independent of the others: hydrogen; ハロゲン、-NO ２ 、-N ３ 、-CN、-OR ４１０ａ 、-SR ４１０ａ 、-N(R ４１０ａ ) ２ 、-C(O)R ４１０ａ 、-C(O)N(R ４１０ａ ) ２ 、-N(R ４１０ａ )C(O)R ４１０ａ 、-N(R ４１０ａ )C(O)N(R ４１０ａ ) ２ 、-OC(O)N(R ４１０ａ ) ２ 、-N(R ４１０ａ )C(O)OR ４１０ａ 、-C(O)OR ４１０ａ 、-OC(O)R ４１０ａ 、-S(O)R ４１０ａ 、および-S(O) ２ R ４１０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ａ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Here X ４２ C(H) and X ４３ C(H) and X ４４ If C(H), then R ４１ａ teeth: ハロゲン、-NO ２ 、-N ３ 、-CN、-OR ４１０ａ 、-SR ４１０ａ 、-N(R ４１０ａ ) ２ 、-C(O)R ４１０ａ 、-C(O)N(R ４１０ａ ) ２ 、-N(R ４１０ａ )C(O)R ４１０ａ 、-N(R ４１０ａ )C(O)N(R ４１０ａ ) ２ 、-OC(O)N(R ４１０ａ ) ２ 、-N(R ４１０ａ )C(O)OR ４１０ａ 、-C(O)OR ４１０ａ 、-OC(O)R ４１０ａ 、-S(O)R ４１０ａ 、および-S(O) ２ R ４１０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ａ Each of which is substituted as necessary by one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ４Ｚ teeth: -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -C(O)OR １０ｚ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｚ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｚ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ４Ｃ teeth: Hydrogen; -C(O)R ４１０ｃ , -C(O)N(R ４１０ｃ ) ２ , -C(O)OR ４１０ｃ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ｃ ,-SR ４１０ｃ , -N(R ４１０ｃ ) ２ , -C(O)R ４１０ｃ , -C(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)R ４１０ｃ , -C(O)OR ４１０ｃ , -OC(O)R ４１０ｃ , -N(R ４１０ｃ ) C(O)N(R ４１０ｃ ) ２ , -OC(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)OR ４１０ｃ , -S(O)R ４１０ｃ , -S(O) ２ R ４１０ｃ , -NO ２ , =O, =S, =N(R ４１０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ｃ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｃ ,-SR ４１０ｃ , -N(R ４１０ｃ ) ２ , -C(O)R ４１０ｃ , -C(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)R ４１０ｃ , -N(R ４１０ｃ ) C(O)N(R ４１０ｃ ) ２ , -OC(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)OR ４１０ｃ , -C(O)OR ４１０ｃ , -OC(O)R ４１０ｃ , -S(O)R ４１０ｃ , -S(O) ２ R ４１０ｃ , -NO ２ , =O, =S, =N(R ４１０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ｃ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ４５ teeth: Hydrogen; halogen, -OR ４１０ｄ ,-SR ４１０ｄ , -N(R ４１０ｄ ) ２ , -C(O)R ４１０ｄ , -C(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)R ４１０ｄ , -C(O)OR ４１０ｄ , -OC(O)R ４１０ｄ , -N(R ４１０ｄ ) C(O)N(R ４１０ｄ ) ２ , -OC(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)OR ４１０ｄ , -S(O)R ４１０ｄ , -S(O) ２ R ４１０ｄ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ｄ ,-SR ４１０ｄ , -N(R ４１０ｄ ) ２ , -C(O)R ４１０ｄ , -C(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)R ４１０ｄ , -C(O)OR ４１０ｄ , -OC(O)R ４１０ｄ , -N(R ４１０ｄ ) C(O)N(R ４１０ｄ ) ２ , -OC(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)OR ４１０ｄ , -S(O)R ４１０ｄ , -S(O) ２ R ４１０ｄ , -NO ２ , =O, =S, =N(R ４１０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ｄ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｄ ,-SR ４１０ｄ , -N(R ４１０ｄ ) ２ , -C(O)R ４１０ｄ , -C(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)R ４１０ｄ , -N(R ４１０ｄ ) C(O)N(R ４１０ｄ ) ２ , -OC(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)OR ４１０ｄ , -C(O)OR ４１０ｄ , -OC(O)R ４１０ｄ , -S(O)R ４１０ｄ , -S(O) ２ R ４１０ｄ , -NO ２ , =O, =S, =N(R ４１０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ｄ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ４５ is R ４６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ４９ｄ It is optionally substituted with one or more substituents selected independently of it; R ４６ teeth: Hydrogen; halogen, -OR ４１０ｅ ,-SR ４１０ｅ , -N(R ４１０ｅ ) ２ , -C(O)R ４１０ｅ , -C(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)R ４１０ｅ , -C(O)OR ４１０ｅ , -OC(O)R ４１０ｅ , -N(R ４１０ｅ ) C(O)N(R ４１０ｅ ) ２ , -OC(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)OR ４１０ｅ , -S(O)R ４１０ｅ , -S(O) ２ R ４１０ｅ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ｅ ,-SR ４１０ｅ , -N(R ４１０ｅ ) ２ , -C(O)R ４１０ｅ , -C(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)R ４１０ｅ , -C(O)OR ４１０ｅ , -OC(O)R ４１０ｅ , -N(R ４１０ｅ ) C(O)N(R ４１０ｅ ) ２ , -OC(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)OR ４１０ｅ , -S(O)R ４１０ｅ , -S(O) ２ R ４１０ｅ , -NO ２ , =O, =S, =N(R ４１０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ｅ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｅ ,-SR ４１０ｅ , -N(R ４１０ｅ ) ２ , -C(O)R ４１０ｅ , -C(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)R ４１０ｅ , -N(R ４１０ｅ ) C(O)N(R ４１０ｅ ) ２ , -OC(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)OR ４１０ｅ , -C(O)OR ４１０ｅ , -OC(O)R ４１０ｅ , -S(O)R ４１０ｅ , -S(O) ２ R ４１０ｅ , -NO ２ , =O, =S, =N(R ４１０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ｅ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ４６ is R ４５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ４９ｅ It is optionally substituted with one or more substituents selected independently of it; R ４７ teeth: Hydrogen; -C(O)R ４１０ｆ , -C(O)N(R ４１０ｆ ) ２ , -C(O)OR ４１０ｆ , -S(O)R ４１０ｆ , and -S(O) ２ R ４１０ｆ ; Halogen, -OR ４１０ｆ ,-SR ４１０ｆ , -N(R ４１０ｆ ) ２ , -C(O)R ４１０ｆ , -C(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)R ４１０ｆ , -C(O)OR ４１０ｆ , -OC(O)R ４１０ｆ , -N(R ４１０ｆ ) C(O)N(R ４１０ｆ ) ２ , -OC(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)OR ４１０ｆ , -S(O)R ４１０ｆ , -S(O) ２ R ４１０ｆ , -NO ２ , =O, =S, =N(R ４１０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｆ ,-SR ４１０ｆ , -N(R ４１０ｆ ) ２ , -C(O)R ４１０ｆ , -C(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)R ４１０ｆ , -N(R ４１０ｆ ) C(O)N(R ４１０ｆ ) ２ , -OC(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)OR ４１０ｆ , -C(O)OR ４１０ｆ , -OC(O)R ４１０ｆ , -S(O)R ４１０ｆ , -S(O) ２ R ４１０ｆ , -NO ２ , =O, =S, =N(R ４１０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ４８ teeth: Hydrogen; -C(O)R ４１０ｇ , -C(O)N(R ４１０ｇ ) ２ , -C(O)OR ４１０ｇ , -S(O)R ４１０ｇ , and -S(O) ２ R ４１０ｇ ; Halogen, -OR ４１０ｇ ,-SR ４１０ｇ , -N(R ４１０ｇ ) ２ , -C(O)R ４１０ｇ , -C(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)R ４１０ｇ , -C(O)OR ４１０ｇ , -OC(O)R ４１０ｇ , -N(R ４１０ｇ ) C(O)N(R ４１０ｇ ) ２ , -OC(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)OR ４１０ｇ , -S(O)R ４１０ｇ , -S(O) ２ R ４１０ｇ , -NO ２ , =O, =S, =N(R ４１０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ４９ｇ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｇ ,-SR ４１０ｇ , -N(R ４１０ｇ ) ２ , -C(O)R ４１０ｇ , -C(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)R ４１０ｇ , -N(R ４１０ｇ ) C(O)N(R ４１０ｇ ) ２ , -OC(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)OR ４１０ｇ , -C(O)OR ４１０ｇ , -OC(O)R ４１０ｇ , -S(O)R ４１０ｇ , -S(O) ２ R ４１０ｇ , -NO ２ , =O, =S, =N(R ４１０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ４９ｇ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R ４９ａ Independently: Halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -C(O)R ４１０ａ , -C(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)R ４１０ａ , -N(R ４１０ａ ) C(O)N(R ４１０ａ ) ２ , -OC(O)N(R ４１０ａ ) ２ , -N(R ４１０ａ ) C(O)OR ４１０ａ , -C(O)OR ４１０ａ , -OC(O)R ４１０ａ , -S(O)R ４１０ａ , -S(O) ２ R ４１０ａ , -NO ２ , =O, =S, =N(R ４１０ａ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｂＡ , R ４９ｂＢ , R ４９ｂＣ , R ４９ｂＤ , and R ４９ｂＥ Independently: Hydrogen; halogen, -NO ２ , -N ３ -CN, -OR ４１０ｂ ,-SR ４１０ｂ , -N(R ４１０ｂ ) ２ , -C(O)R ４１０ｂ , -C(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)R ４１０ｂ , -N(R ４１０ｂ ) C(O)N(R ４１０ｂ ) ２ , -OC(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)OR ４１０ｂ , -C(O)OR ４１０ｂ , -OC(O)R ４１０ｂ , -S(O)R ４１０ｂ , and -S(O) ２ R ４１０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR ４１０ｂ ,-SR ４１０ｂ , -N(R ４１０ｂ ) ２ , -C(O)R ４１０ｂ , -C(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)R ４１０ｂ , -C(O)OR ４１０ｂ , -OC(O)R ４１０ｂ , -N(R ４１０ｂ ) C(O)N(R ４１０ｂ ) ２ , -OC(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)OR ４１０ｂ , -S(O)R ４１０ｂ , -S(O) ２ R ４１０ｂ , -NO ２ , =O, =S, =N(R ４１０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ｂ ,-SR ４１０ｂ , -N(R ４１０ｂ ) ２ , -C(O)R ４１０ｂ , -C(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)R ４１０ｂ , -N(R ４１０ｂ ) C(O)N(R ４１０ｂ ) ２ , -OC(O)N(R ４１０ｂ ) ２ , -N(R ４１０ｂ ) C(O)OR ４１０ｂ , -C(O)OR ４１０ｂ , -OC(O)R ４１０ｂ , -S(O)R ４１０ｂ , -S(O) ２ R ４１０ｂ , -NO ２ , =O, =S, =N(R ４１０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R ４９ｚ Independently: Halogen, -OR ４１０ｚ ,-SR ４１０ｚ , -N(R ４１０ｚ ) ２ , -C(O)R ４１０ｚ , -C(O)N(R ４１０ｚ ) ２ , -N(R ４１０ｚ ) C(O)R ４１０ｚ , -N(R ４１０ｚ ) C(O)N(R ４１０ｚ ) ２ , -OC(O)N(R ４１０ｚ ) ２ , -N(R ４１０ｚ ) C(O)OR ４１０ｚ , -C(O)OR ４１０ｚ , -OC(O)R ４１０ｚ , -S(O)R ４１０ｚ , -S(O) ２ R ４１０ｚ , -NO ２ , =O, =S, =N(R ４１０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｚ ,-SR ４１０ｚ , -N(R ４１０ｚ ) ２ , -C(O)R ４１０ｚ , -C(O)N(R ４１０ｚ ) ２ , -N(R ４１０ｚ ) C(O)R ４１０ｚ , -N(R ４１０ｚ ) C(O)N(R ４１０ｚ ) ２ , -OC(O)N(R ４１０ｚ ) ２ , -N(R ４１０ｚ ) C(O)OR ４１０ｚ , -C(O)OR ４１０ｚ , -OC(O)R ４１０ｚ , -S(O)R ４１０ｚ , -S(O) ２ R ４１０ｚ , -NO ２ , =O, =S, =N(R ４１０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｃ Independently: Halogen, -OR ４１０ｃ ,-SR ４１０ｃ , -N(R ４１０ｃ ) ２ , -C(O)R ４１０ｃ , -C(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)R ４１０ｃ , -N(R ４１０ｃ ) C(O)N(R ４１０ｃ ) ２ , -OC(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)OR ４１０ｃ , -C(O)OR ４１０ｃ , -OC(O)R ４１０ｃ , -S(O)R ４１０ｃ , -S(O) ２ R ４１０ｃ , -NO ２ , =O, =S, =N(R ４１０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｃ ,-SR ４１０ｃ , -N(R ４１０ｃ ) ２ , -C(O)R ４１０ｃ , -C(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)R ４１０ｃ , -N(R ４１０ｃ ) C(O)N(R ４１０ｃ ) ２ , -OC(O)N(R ４１０ｃ ) ２ , -N(R ４１０ｃ ) C(O)OR ４１０ｃ , -C(O)OR ４１０ｃ , -OC(O)R ４１０ｃ , -S(O)R ４１０ｃ , -S(O) ２ R ４１０ｃ , -NO ２ , =O, =S, =N(R ４１０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｄ Independently: Halogen, -OR ４１０ｄ ,-SR ４１０ｄ , -N(R ４１０ｄ ) ２ , -C(O)R ４１０ｄ , -C(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)R ４１０ｄ , -N(R ４１０ｄ ) C(O)N(R ４１０ｄ ) ２ , -OC(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)OR ４１０ｄ , -C(O)OR ４１０ｄ , -OC(O)R ４１０ｄ , -S(O)R ４１０ｄ , -S(O) ２ R ４１０ｄ , -NO ２ , =O, =S, =N(R ４１０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｄ ,-SR ４１０ｄ , -N(R ４１０ｄ ) ２ , -C(O)R ４１０ｄ , -C(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)R ４１０ｄ , -N(R ４１０ｄ ) C(O)N(R ４１０ｄ ) ２ , -OC(O)N(R ４１０ｄ ) ２ , -N(R ４１０ｄ ) C(O)OR ４１０ｄ , -C(O)OR ４１０ｄ , -OC(O)R ４１０ｄ , -S(O)R ４１０ｄ , -S(O) ２ R ４１０ｄ , -NO ２ , =O, =S, =N(R ４１０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｅ Independently: Halogen, -OR ４１０ｅ ,-SR ４１０ｅ , -N(R ４１０ｅ ) ２ , -C(O)R ４１０ｅ , -C(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)R ４１０ｅ , -N(R ４１０ｅ ) C(O)N(R ４１０ｅ ) ２ , -OC(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)OR ４１０ｅ , -C(O)OR ４１０ｅ , -OC(O)R ４１０ｅ , -S(O)R ４１０ｅ , -S(O) ２ R ４１０ｅ , -NO ２ , =O, =S, =N(R ４１０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｅ ,-SR ４１０ｅ , -N(R ４１０ｅ ) ２ , -C(O)R ４１０ｅ , -C(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)R ４１０ｅ , -N(R ４１０ｅ ) C(O)N(R ４１０ｅ ) ２ , -OC(O)N(R ４１０ｅ ) ２ , -N(R ４１０ｅ ) C(O)OR ４１０ｅ , -C(O)OR ４１０ｅ , -OC(O)R ４１０ｅ , -S(O)R ４１０ｅ , -S(O) ２ R ４１０ｅ , -NO ２ , =O, =S, =N(R ４１０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｆ Independently: Halogen, -OR ４１０ｆ ,-SR ４１０ｆ , -N(R ４１０ｆ ) ２ , -C(O)R ４１０ｆ , -C(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)R ４１０ｆ , -N(R ４１０ｆ ) C(O)N(R ４１０ｆ ) ２ , -OC(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)OR ４１０ｆ , -C(O)OR ４１０ｆ , -OC(O)R ４１０ｆ , -S(O)R ４１０ｆ , -S(O) ２ R ４１０ｆ , -NO ２ , =O, =S, =N(R ４１０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｆ ,-SR ４１０ｆ , -N(R ４１０ｆ ) ２ , -C(O)R ４１０ｆ , -C(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)R ４１０ｆ , -N(R ４１０ｆ ) C(O)N(R ４１０ｆ ) ２ , -OC(O)N(R ４１０ｆ ) ２ , -N(R ４１０ｆ ) C(O)OR ４１０ｆ , -C(O)OR ４１０ｆ , -OC(O)R ４１０ｆ , -S(O)R ４１０ｆ , -S(O) ２ R ４１０ｆ , -NO ２ , =O, =S, =N(R ４１０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ４９ｇ Independently: Halogen, -OR ４１０ｇ ,-SR ４１０ｇ , -N(R ４１０ｇ ) ２ , -C(O)R ４１０ｇ , -C(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)R ４１０ｇ , -N(R ４１０ｇ ) C(O)N(R ４１０ｇ ) ２ , -OC(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)OR ４１０ｇ , -C(O)OR ４１０ｇ , -OC(O)R ４１０ｇ , -S(O)R ４１０ｇ , -S(O) ２ R ４１０ｇ , -NO ２ , =O, =S, =N(R ４１０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR ４１０ｇ ,-SR ４１０ｇ , -N(R ４１０ｇ ) ２ , -C(O)R ４１０ｇ , -C(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)R ４１０ｇ , -N(R ４１０ｇ ) C(O)N(R ４１０ｇ ) ２ , -OC(O)N(R ４１０ｇ ) ２ , -N(R ４１０ｇ ) C(O)OR ４１０ｇ , -C(O)OR ４１０ｇ , -OC(O)R ４１０ｇ , -S(O)R ４１０ｇ , -S(O) ２ R ４１０ｇ , -NO ２ , =O, =S, =N(R ４１０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R ４１０ａ , R ４１０ｂ , R ４１０ｃ , R ４１０ｄ , R ４１０ｅ , R ４１０ｆ , R ４１０ｇ Independently: hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. A compound or a salt thereof, selected from the above.

90. The compound or salt according to claim 89, wherein the compound or salt is neither 601, 602, 603, 604, 605, 606, nor any salt thereof. 【Request Item 91】 【Chemistry 201】 Two of these are selected from: a dibond, the compound or salt according to claim 89 or claim 90.

92. X ４１ , X ４２ , X ４３ , and X ４４ One or fewer of these is N or N ＋ (-O － ) and Y ４１ , Y ４２ , Y ４３ , Y ４４ , and Y ４５ One or fewer of these is N or N ＋ (-O － The compound or salt according to any one of claims 89 to 91.

93. X ４１ , X ４２ , X ４３ , and X ４４ The compound or salt according to any one of claims 89 to 92, wherein each of is independently selected from N, C(H), C(F), and C(CN).

94. X ４３ and X ４４ A compound or salt according to any one of claims 89 to 93, wherein is C(H).

95. R ４１ａ , R ４１ｂ , R ４１ｃ , and R ４１ｄ Each of these independently consists of: hydrogen, fluorocarbon, -CN, and C １～６ A compound or salt according to any one of claims 89 to 94, selected from alkyl groups.

96. R ４Ｚ However, C １ A compound or salt according to any one of claims 89 to 95, selected from alkyl groups.

97. R ４Ｃ A: A compound or salt according to any one of claims 89 to 96, selected from hydrogen.

98. R ４５ is hydrogen, and R ４６ A compound or salt according to any one of claims 89 to 97, wherein is hydrogen.

99. R ４７ A compound or salt according to any one of claims 89 to 98, wherein hydrogen is selected.

100. Y ４１ A compound or salt according to any one of claims 89 to 99, selected from C.

101. Y ４２ , Y ４３ , Y ４４ , and Y ４５ The compound or salt according to any one of claims 89 to 100, wherein each of the elements is independently selected from C(H), C(CN), C(F), C(Cl), C(OH), N, O, and S.

102. Y ４２ , Y ４３ , Y ４４ , and Y ４５ The compound or salt according to any one of claims 89 to 101, wherein each of the elements is independently selected from C(H), C(CN), C(F), C(Cl), C(OH), and N.

103. R ４８ a: A compound or salt according to any one of claims 89 to 102, selected from hydrogen.

104. R ９ｂＡ , R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ Each independently: hydrogen, halogen, -CN, -OR ４１０ｂ , C １～６ A compound or salt according to any one of claims 89 to 103, selected from alkyl groups.

105. Each R ４１０ａ , R ４１０ｂ , R ４１０ｚ , R ４１０ｃ , R ４１０ｄ , R ４１０ｅ , R ４１０ｆ , and R ４１０ｇ A compound or salt according to any one of claims 89 to 104, wherein the compound or salt is independently selected from hydrogen.

106. X ４１ C(H) and X ４２ C(H) and X ４３ If C(H), then R ４１ｄ ga: halogen, -NO ２ -CN, -OR ４１０ａ ,-SR ４１０ａ , and -N(R ４１０ａ ) ２ ; Halogen, -OR ４１０ａ ,-SR ４１０ａ , and -N(R ４１０ａ ) ２ , = O, -CN, C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR ４１０ａ ,-SR ４１０ａ , -N(R ４１０ａ ) ２ , -NO ２ , =O, -CN, and C １～６ The compound or salt according to any one of claims 89 to 105, selected from those optionally substituted with one or more substituents independently selected from alkyl.

107. R ４２ but, 【Chemical Engineering 202】 Selected from, here: Y ４２ C(R) ４９ｂＢ ), N, and N ＋ (-O － ) selected from; Y ４３ C(R) ４９ｂＣ ), N, and N ＋ (-O － ) selected from; Y ４４ C(R) ４９ｂＤ ), N, and N ＋ (-O － ) is selected from; and Y ４５ C(R) ４９ｂＥ ), N, and N ＋ (-O － A compound or salt according to any one of claims 89 to 106, selected from ).

108. R ４２ but, 【Chemical 203】 Selected from, here: Y ４２ C(R) ４９ｂＢ ) ２ , N(R ４９ｂＢ ), N ＋ (R ４９ｂＢ ) (-O － Selected from O, and S; Y ４３ C(R) ４９ｂＣ ), N, and N ＋ (-O － ) selected from; Y ４４ C(R) ４９ｂＤ ), N, and N ＋ (-O － ) is selected from; and Y ４５ C(R) ４９ｂＥ ), N, and N ＋ (-O － A compound or salt according to any one of claims 89 to 107, selected from ).

109. R ４２ but, 【Chemical 204】 Selected from, here: Y ４２ C(R) ４９ｂＢ ), N, and N ＋ (-O － ) selected from; Y ４３ C(R) ４９ｂＣ ) ２ , N(R ４９ｂＣ ), N ＋ (R ４９ｂＣ ) (-O － Selected from O, and S; Y ４４ C(R) ４９ｂＤ ), N, and N ＋ (-O － ) is selected from; and Y ４５ C(R) ４９ｂＥ ), N, and N ＋ (-O － A compound or salt according to any one of claims 89 to 108, selected from ).

110. R ４２ but, 【Chemical 205】 Selected from, here: Y ４２ C(R) ４９ｂＢ ), N, and N ＋ (-O － ) selected from; Y ４３ C(R) ４９ｂＣ ), N, and N ＋ (-O － ) selected from; Y ４４ C(R) ４９ｂＤ ) ２ , N(R ４９ｂＤ ), N ＋ (R ４９ｂＤ ) (-O － ), selected from O and S; and Y ４５ C(R) ４９ｂＥ ), N, and N ＋ (-O － A compound or salt according to any one of claims 89 to 109, selected from ); or R ４２ but: 【Chemical 206】 Selected from, here Y ４２ C(R) ４９ｂＢ ), N, and N ＋ (-O － ) selected from; Y ４３ C(R) ４９ｂＣ ), N, and N ＋ (-O － ) selected from; Y ４４ C(R) ４９ｂＤ ), N, and N ＋ (-O － ) is selected from; and Y ４５ C(R) ４９ｂＥ ) ２ , N(R ４９ｂＥ ), N ＋ (R ４９ｂＥ ) (-O － A compound or salt according to any one of claims 89 to 109, selected from ), O, and S.

111. R ４２ but: 【Chemical 207】 A compound or salt according to any one of claims 89 to 110, selected from the above.

112. Formula (Id): 【Chemical 208】 A compound or salt thereof represented by formula (Id): R ２ teeth: 【Chemical Engineering 209】 Selected from; u is an integer selected from 0, 1, 2, and 3; Z １ ha: -C(R Ｚ ) ２ -, -N(R Ｚ ) -, -N ＋ (-O － Selected from ), -O-, and -S-; Each Z ２ is independently: -C(R Ｚ ) (Caution Ｚ’ )-,-N(R Ｚ ) -, -N ＋ (-O － Selected from ), -O-, and -S-; X １ C(R) １ａ ), N, and N ＋ (-O － ) are selected from; X ２ C(R) １ｂ ), N, and N ＋ (-O － ) are selected from; X ３ C(R) １ｃ ), N, and N ＋ (-O － ) are selected from; X ４ C(R) １ｄ ), N, and N ＋ (-O － ) are selected from; Here X １ , X ２ , X ３ , and X ４ Two or fewer of these are N or -N ＋ (-O － ) and; Y ２ C(R) ９ｂＢ ), N, and N ＋ (-O － ) are selected from; Y ３ C(R) ９ｂＣ ), N, and N ＋ (-O － ) are selected from; Y ４ C(R) ９ｂＤ ), N, and N ＋ (-O － ) are selected from; Y ５ C(R) ９ｂＥ ), N, and N ＋ (-O － ) are selected from; Here Y ２ , Y ３ , Y ４ , and Y ５ Three or fewer of these are N or -N ＋ (-O － ) and; R １ａ , R １ｂ , R １ｃ , and R １ｄ Each is independent of the others: Hydrogen; halogen, -NO ２ , -N ３ -CN, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , and -S(O) ２ R １０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ａ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R Ｚ Independently: Hydrogen; -CN, -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , and -C(O)OR １０ｚ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｚ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｚ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R Ｚ’ Independently: Hydrogen; -CN, -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , and -C(O)OR １０ｚ ; Halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C ３～１０ C substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles １ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles have one or more R ９ｚ Each of these is replaced as needed; C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｚ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｚ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R Ｃ teeth: --&N---ORR １０ｃ 、-C(O)N(R １０ｃ ) ２ 、-C(O)OR １０ｃ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｃ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｃ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ５ teeth: Hydrogen; halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｄ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｄ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ５ is R ６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｄ It is optionally substituted with one or more substituents selected independently of it; R ６ teeth: Hydrogen; halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , -N ３ , and -CN; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｅ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｅ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; or R ６ is R ５ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｅ It is optionally substituted with one or more substituents selected independently of it; R ７ teeth: Hydrogen; -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -C(O)OR １０ｆ , -S(O)R １０ｆ , and -S(O) ２ R １０ｆ ; Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｆ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｆ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ８ teeth: Hydrogen; -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -C(O)OR １０ｇ , -S(O)R １０ｇ , and -S(O) ２ R １０ｇ ; Halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -N(R １０ｇ ) C(O)R １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ ,-CN,C ３～１０ C is optionally substituted with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles. １～６ Alkyl, where C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｇ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｇ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; Each R ９ａ Independently: Halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ , and selected from those which are optionally substituted with one or more substituents independently selected from -CN; R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ Each is independent of the others: Hydrogen; halogen, -NO ２ , -N ３ -CN, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , and -S(O) ２ R １０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; Each R ９ｚ Independently: Halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｚ ,-SR １０ｚ , -N(R １０ｚ ) ２ , -C(O)R １０ｚ , -C(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)R １０ｚ , -N(R １０ｚ ) C(O)N(R １０ｚ ) ２ , -OC(O)N(R １０ｚ ) ２ , -N(R １０ｚ ) C(O)OR １０ｚ , -C(O)OR １０ｚ , -OC(O)R １０ｚ , -S(O)R １０ｚ , -S(O) ２ R １０ｚ , -NO ２ , =O, =S, =N(R １０ｚ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｃ Independently: Halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｄ Independently: Halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -C(O)R １０ｄ , -C(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)R １０ｄ , -N(R １０ｄ ) C(O)N(R １０ｄ ) ２ , -OC(O)N(R １０ｄ ) ２ , -N(R １０ｄ ) C(O)OR １０ｄ , -C(O)OR １０ｄ , -OC(O)R １０ｄ , -S(O)R １０ｄ , -S(O) ２ R １０ｄ , -NO ２ , =O, =S, =N(R １０ｄ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｅ Independently: Halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -C(O)R １０ｅ , -C(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)R １０ｅ , -N(R １０ｅ ) C(O)N(R １０ｅ ) ２ , -OC(O)N(R １０ｅ ) ２ , -N(R １０ｅ ) C(O)OR １０ｅ , -C(O)OR １０ｅ , -OC(O)R １０ｅ , -S(O)R １０ｅ , -S(O) ２ R １０ｅ , -NO ２ , =O, =S, =N(R １０ｅ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｆ Independently: Halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｆ ,-SR １０ｆ , -N(R １０ｆ ) ２ , -C(O)R １０ｆ , -C(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)R １０ｆ , -N(R １０ｆ ) C(O)N(R １０ｆ ) ２ , -OC(O)N(R １０ｆ ) ２ , -N(R １０ｆ ) C(O)OR １０ｆ , -C(O)OR １０ｆ , -OC(O)R １０ｆ , -S(O)R １０ｆ , -S(O) ２ R １０ｆ , -NO ２ , =O, =S, =N(R １０ｆ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｇ Independently: Halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ , and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｇ ,-SR １０ｇ , -N(R １０ｇ ) ２ , -C(O)R １０ｇ , -C(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)R １０ｇ , -N(R １０ｇ ) C(O)N(R １０ｇ ) ２ , -OC(O)N(R １０ｇ ) ２ , -N(R １０ｇ ) C(O)OR １０ｇ , -C(O)OR １０ｇ , -OC(O)R １０ｇ , -S(O)R １０ｇ , -S(O) ２ R １０ｇ , -NO ２ , =O, =S, =N(R １０ｇ ), -N ３ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; and Each R １０ａ , R １０ｂ , R １０ｚ , R １０ｃ , R １０ｄ , R １０ｅ , R １０ｆ , and R １０ｇ Independently: Hydrogen; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Here X １ C(H) and X ２ C(H) and X ３ C(H) and X ４ If C(H); R ９ｂＣ teeth: Halogen, -NO ２ , -N ３ , -CN, -OH, -O(C ２～６ alkyl), -O(C １～６ haloalkyl), -SR １０ｂ , -NH(C １～６ alkyl), -N(C １～６ alkyl) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ),C(O)R １０ｂ , -N(R １０ｂ ),C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ),C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , and -S(O) ２ R １０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; R ７ ga-CH ３ And R ８ ga-CH ３ And X ４ 1N or -N ＋ (-O － ) If R １ｃ teeth, Hydrogen; halogen, -NO ２ , -N ３ -CN, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , and -S(O) ２ R １０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl, each of which is chloro, bromo, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ ,-CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ａ Each substituent is substituted as needed by one or more substituents independently selected from the original; C substituted with one or two -F １ Alkyl; C substituted with one or more -F ２～６ alkyl; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; X １ C(H) and X ２ C(H) and X ３ C(H) and X ４ C(H) and Z １ ga-CH ２ - and u is 2 and each Z ２ ga-CH ２ - or -O- and Y ２ C(H) and Y ３ C(H) and Y ４ If C(H); R ９ｂＥ teeth: Fluoro, chloro, iodine, -NO ２ , -N ３ -CN, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , and -S(O) ２ R １０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. Selected from; and X １ C(H) and X ２ C(H) and X ３ C(H) and X ４ C(H) and Z １ ga-CH ２ - and u is 1 and Z ２ ga-CH ２ - and Y ５ C(H) and Y ３ C(H) and Y ４ If C(H); R ９ｂＢ teeth, Hydrogen; chloro, bromo, iodine, -NO ２ , -N ３ -CN, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , and -S(O) ２ R １０ｂ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C ３～１０ Substituted as necessary with one or more substituents independently selected from carbocyclic and 3- to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -N ３ ,-CN,C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Substituted as needed with one or more substituents independently selected from the alkynyl group. A compound or a salt thereof, selected from Y. ２ , Y ３ , Y ４ , and Y ５ The compound or salt according to claim 112, wherein at least one of the elements is N.

113. The compound or salt according to claim 112, wherein the compound or salt is neither compound 703 nor a salt thereof.

114. X ３ and X ４ The compound or salt according to claim 112 or claim 113, wherein is C(H).

115. R １ａ , R １ｂ , R １ｃ , and R １ｄ Each of these independently: hydrogen, fluorocarbon, and C １ A compound or salt according to any one of claims 112 to 114, selected from alkyl groups.

116. Each R Ｚ A compound or salt according to any one of claims 112 to 115, wherein is independently selected from hydrogen.

117. R Ｃ A: A compound or salt according to any one of claims 112 to 116, selected from hydrogen.

118. R ５ is hydrogen, and R ６ A compound or salt according to any one of claims 112 to 117, wherein is hydrogen.

119. R ７ and R ８ A compound or salt according to any one of claims 112 to 118, wherein each is independently selected from hydrogen.

120. R ２ but, 【Chemical 210】 A compound or salt according to any one of claims 112 to 119, selected from among them.

121. R ９ｂＢ , R ９ｂＣ , R ９ｂＤ , and R ９ｂＥ A compound or salt according to any one of claims 112 to 120, wherein each of the following is independently selected from: hydrogen, fluoro, and -CN.

122. A compound or salt according to any one of claims 112 to 121, selected from compounds 9, 10, 44, 48, 43, 46, 57, 701, and 702, or a salt of any one of these.

123. A pharmaceutical composition comprising a compound or salt according to any one of claims 1 to 122 and a pharmaceutically acceptable additive.

124. A method for treating a cardiovascular disease or related condition, comprising the step of administering to a subject in need of such treatment a compound or salt according to any one of claims 1 to 122, or a pharmaceutical composition according to claim 123.

125. A method for treating cardiovascular disease or related conditions, wherein the subject in need is given formula (IIIa) 【Chemistry 211】 The process includes administering the compound or salt thereof, or a salt thereof, in formula (IIIa), X １ , X ２ , X ３ , and X ４ Each is independent of C(R) １ ), N, and N ＋ (-O － ) are selected from; Here X １ , X ２ , X ３ , and X ４ Two or fewer of these are N or N ＋ (-O － ) and; Each R １ Independently: hydrogen; ハロゲン、-NO ２ 、-CN、-OR １０ａ 、-SR １０ａ 、-N(R １０ａ ) ２ 、-C(O)R １０ａ 、-C(O)N(R １０ａ ) ２ 、-N(R １０ａ )C(O)R １０ａ 、-N(R １０ａ )C(O)N(R １０ａ ) ２ 、-OC(O)N(R １０ａ ) ２ 、-N(R １０ａ )C(O)OR １０ａ 、-C(O)OR １０ａ 、-OC(O)R １０ａ 、-S(O)R １０ａ 、および-S(O) ２ R １０ａ ; C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -CN, C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ａ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ａ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ２ teeth: C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, -CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｂ Each of which is substituted as necessary with one or more substituents independently selected from; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｂ Each of which is substituted as needed by one or more substituents independently selected from the original. Selected from; R ５ and R ６ Each is independent of the others: Hydrogen, halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -NO ２ , and -CN; C １～６ Alkyl, C ２～６～ Alkenyl and C ２～６ Alkynnyl, where any of these is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -NO ２ , -CN, and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -NO ２ , and one or more substituents independently selected from those which are optionally substituted with one or more substituents independently selected from -CN, which are optionally substituted with one or more substituents independently selected from -CN; and C ３～１０ Carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -NO ２ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; or R ５ is R ６ Together with it, a 3-membered to 10-membered hetero ring or C ３～１０ A carbon ring is formed, where the 3-membered to 10-membered heterocycle or C ３～１０ The carbon ring is R ９ｃ It is optionally substituted with one or more substituents selected independently of it; R ７ teeth: Hydrogen, as well as halogens, -OR １０ｄ ,-SR １０ｄ , -N(R １０ｄ ) ２ , -NO ２ , and C as needed, substituted with one or more substituents independently selected from -CN １～６ Selected from alkyl groups; R ８ teeth: Hydrogen; and Halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -NO ２ , -CN, and C as needed, substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles １ Alkyl compounds, where each 3- to 10-membered heterocycle is a halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -NO ２ , and, as needed, substituted with one or more substituents independently selected from -CN; Halogen, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -NO ２ ,-CN,C ３～１０ A carbon ring and a carbon ring, optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles. ２～６ Alkyl, where each C ３～１０ Carbon rings and 3- to 10-membered heterocycles contain halogens, -OR １０ｅ ,-SR １０ｅ , -N(R １０ｅ ) ２ , -NO ２ , and which are optionally substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ａ Independently: Halogen, -OH, -O(C) ２～６ Alkyl), -O (C １～６ Haloalkyl), -SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ａ ,-SR １０ａ , -N(R １０ａ ) ２ , -C(O)R １０ａ , -C(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)R １０ａ , -N(R １０ａ ) C(O)N(R １０ａ ) ２ , -OC(O)N(R １０ａ ) ２ , -N(R １０ａ ) C(O)OR １０ａ , -C(O)OR １０ａ , -OC(O)R １０ａ , -S(O)R １０ａ , -S(O) ２ R １０ａ , -NO ２ , =O, =S, =N(R １０ａ ), and as needed, substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｂ Independently: Halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), and as needed, substituted with one or more substituents independently selected from -CN. Selected from; Each R ９ｃ Independently: Halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), and -CN; and C １～３ Alkyl, C ２～３ Alkenyl and C ２～３ Alkynnyl, each of which is a halogen, -OR １０ｃ ,-SR １０ｃ , -N(R １０ｃ ) ２ , -C(O)R １０ｃ , -C(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)R １０ｃ , -N(R １０ｃ ) C(O)N(R １０ｃ ) ２ , -OC(O)N(R １０ｃ ) ２ , -N(R １０ｃ ) C(O)OR １０ｃ , -C(O)OR １０ｃ , -OC(O)R １０ｃ , -S(O)R １０ｃ , -S(O) ２ R １０ｃ , -NO ２ , =O, =S, =N(R １０ｃ ), and as needed, substituted with one or more substituents independently selected from -CN. Selected from; Each R １０ａ Independently: Hydrogen; and C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Each R １０ｂ Independently: Hydrogen; and C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Each R １０ｃ Independently: Hydrogen; and C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Each R １０ｄ Independently: Hydrogen; and C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Each R １０ｅ Independently: Hydrogen; and C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C ３～１０ Carbocyclic rings, or those optionally substituted with one or more substituents independently selected from 3-membered to 10-membered heterocycles; and C ３～１０ Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -CN, -OH, -SH, -NO ２ , -NH ２ , =O, =S, -OC １～６ Alkyl, -S-C １～６ Alkyl, -N(C) １～６ Alkyl) ２ ,-NH(C １～６ Alkyl), C １～６ Alkyl, C ２～６ Alkenil, C ２～６ Alkinyl, C ３～１０ Carbon rings, 3-membered to 10-membered heterocycles, and C １～６ Substituted as needed with one or more substituents independently selected from the haloalkyl group. Selected from; Here R ５ or R ６ If isopropyl; R ２ teeth: C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkynnyl, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, -CN,C ３～１０ The carbon ring is optionally substituted with one or more substituents independently selected from a carbon ring and a 3-membered to 10-membered heterocycle, where the C ３～１０ Carbon rings and 3- to 10-membered heterocycles are R ９ｂ Each substituent is substituted as needed by one or more substituents independently selected from the original; C ３～１０ A carbon ring, a 3- to 4-membered heterocycle, and a 6- to 10-membered heterocycle, each of which is a halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -CN, C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ It is optionally substituted with one or more substituents independently selected from the alkynyl, where C １～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｂ Each of which is substituted as necessary with one or more substituents independently selected from; and Halogen, -OR １０ｂ ,-SR １０ｂ , -N(R １０ｂ ) ２ , -C(O)R １０ｂ , -C(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)R １０ｂ , -N(R １０ｂ ) C(O)N(R １０ｂ ) ２ , -OC(O)N(R １０ｂ ) ２ , -N(R １０ｂ ) C(O)OR １０ｂ , -C(O)OR １０ｂ , -OC(O)R １０ｂ , -S(O)R １０ｂ , -S(O) ２ R １０ｂ , -NO ２ , =O, =S, =N(R １０ｂ ), -CN, C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ A five-membered heterocycle optionally substituted with one or more substituents independently selected from the alkynyl, where C ２～６ Alkyl, C ２～６ Alkenyl and C ２～６ Alkinyl is R ９ｂ Each of which is substituted as needed by one or more substituents independently selected from the original. A method to be selected from.

126. The method according to claim 124 or claim 125, wherein the cardiovascular disease or related condition is selected from hypertrophic cardiomyopathy (HCM); heart failure with preserved ejection fraction (HFpEF); heart failure with mildly reduced ejection fraction; impaired ventricular relaxation; impaired ventricular stiffness (diabetic HFpEF); dilated cardiomyopathy (DCM); ischemic cardiomyopathy; allograft vascular vascular disease; restrictive cardiomyopathy; valvular disease (e.g., aortic stenosis – including post-AVR / TAVR and congenital forms in the elderly); left ventricular (LV) hypertrophy; right ventricular (RV) hypertrophy; acute myocardial infarction; acute vascular regeneration; ischemia; and angina.

127. The method according to claim 126, wherein the ejection fraction-preserved heart failure (HFpEF) comprises one or more disorders selected from impaired relaxation and impaired ventricular stiffness (diabetic HFpEF).

128. The method according to claim 126, wherein the left ventricular (LV) hypertrophy is malignant left ventricular (LV) hypertrophy.

129. The method according to claim 126, wherein the restrictive cardiomyopathy comprises one or more subgroups selected from the inflammatory subgroup, the infiltrative subgroup, the storage subgroup, the idiopathic / hereditary subgroup, and the congenital heart disease subgroup.

130. The method according to claim 129, wherein the inflammatory subgroup comprises one or more subgroups selected from refrel and EMF.

131. The method according to claim 129, wherein the inflammatory subgroup comprises one or more subgroups selected from amyloid, sarcoid, and XRT.

132. The method according to claim 129, wherein the storage subgroup comprises one or more subgroups selected from hemochromatosis, Fabri, and glycogen disease.

133. The method according to claim 129, wherein the idiopathic / hereditary subgroup comprises one or more subgroups selected from the subgroups related to Top I (betamyosin HC), Top T (alpha cardiac actin), and desmin.

134. The method according to claim 129, wherein the subgroup of congenital heart disease comprises one or more subgroups selected from pressure overload RV, Tetralogy of Fallot, and pulmonary valve stenosis.

135. The method according to any one of claims 124 to 126, wherein the cardiovascular disease or related condition is hypertrophic cardiomyopathy.

136. The method according to any one of claims 124 to 126 or 135, wherein the cardiovascular disease or related condition is obstructive hypertrophic cardiomyopathy.

137. The method according to any one of claims 124 to 126 or 135, wherein the cardiovascular disease or related condition is non-obstructive hypertrophic cardiomyopathy.

138. The method according to any one of claims 124 to 137, wherein the cardiovascular disease or related condition includes heart failure with preserved ejection fraction.

139. The method according to any one of claims 124 to 138, wherein the cardiovascular disease or related condition includes left ventricular stiffness.

140. The method according to any one of claims 124 to 139, further comprising the step of administering an additional activator.

141. A method for modulating a myosin-modulating light chain, the method comprising the step of administering to a subject in need of such modulation a compound or salt according to any one of claims 1 to 122, or a pharmaceutical composition according to claim 123.

142. The method according to claim 141, wherein the regulatory light chain is a cardiac myosin regulatory light chain.

143. The method according to any one of claims 141 to 142, wherein the step of administering the compound to a subject requiring the above-mentioned treatment enhances the ability of the myosin lever arm to generate force.

144. The method according to any one of claims 141 to 143, wherein the step of administering the compound to a subject requiring such administration overcomes interference with the interaction between the myosin regulatory light chain and the myosin heavy chain, and, if necessary, the interference is caused by a gene mutation.