Manipulated blood-brain barrier permeable AAV capsid

By inserting targeting peptides into AAV capsids, the engineered AAV capsids enhance CNS targeting and permeability across the blood-brain barrier, achieving efficient gene delivery and expression in multiple brain regions for treating CNS disorders.

JP2026518667APending Publication Date: 2026-06-09SANGAMO THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
SANGAMO THERAPEUTICS INC
Filing Date
2024-05-15
Publication Date
2026-06-09

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Abstract

This application relates to the manipulation of AAV capsids. In some embodiments, the manipulated AAV capsids can penetrate the blood-brain barrier and transduce cells in the central nervous system.
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