Antibody variable domains and antibodies with reduced immunogenicity

JP2026518715APending Publication Date: 2026-06-09NUMAB INNOVATION AG
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
NUMAB INNOVATION AG
Filing Date
2024-05-17
Publication Date
2026-06-09

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Abstract

The present invention relates to an antibody-variable domain with reduced binding to an anti-drug antibody (ADA), an antibody comprising one or more of the antibody-variable domains, and a pharmaceutical composition comprising the antibody. The present invention further relates to a nucleic acid encoding the antibody-variable domain or the antibody, one or more vectors comprising the nucleic acid, one or more host cells comprising the nucleic acid or the vector, and a method for producing the antibody-variable domain or the multispecific antibody. Furthermore, the present invention relates to a method for producing the antibody-variable domain and the antibody.
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