Topical preparations containing hygroscopic substances

Abstract

The present invention relates to a localized anhydrous composition comprising an anhydrous substance, at least one viable microorganism, and a deliquescent substance.

Claims

1. A localized anhydrous composition comprising an anhydrous substance, at least one viable microorganism, and a deliquescent substance.

2. The composition according to claim 1, wherein the weight ratio of the deliquescent substance to the viable microorganisms is in the range of 10:1 to 1:

10.

3. The aforementioned surviving microorganisms, 10 ４ The local anhydrous composition according to claim 1 or 2, which is present in a concentration exceeding CFU / gram.

4. The composition according to any one of claims 1 to 3, wherein the deliquescent substance is a salt that adsorbs water at 25°C, and preferably the absorption of water increases the weight of the deliquescent substance by at least 5% by weight (w / w), more preferably at least 15% by weight (w / w), more preferably at least 30% by weight (w / w), and more preferably 50% by weight (w / w) of the total weight of the absorbed deliquescent substance.

5. The composition according to any one of claims 1 to 4, wherein the deliquescent substance is a salt selected from a water-soluble inorganic salt or a water-soluble organic salt, and preferably the salt is a water-soluble inorganic salt.

6. The deliquescent substance is calcium chloride (CaCl ２ ), magnesium chloride (MgCl ２ ), zinc chloride (ZnCl ２ ), ferric chloride (FeCl ３ ), lithium chloride (LiCl), carnallite (KCl.MgCl ２ ), potassium carbonate (K ２ CO ３ ), sodium acetate anhydrous (CH ３ COONa), ammonium nitrate (NH ４ NO ３ ), potassium hydroxide (KOH), dipotassium phosphate (K ２ HPO ４ ), magnesium nitrate (Mg(NO ３ ) ２ ), sodium formate (NaCHO ２ ), sodium acetate (NaC ２ H ３ O ２ ), trisodium phosphate (Na ３ PO ４ ), magnesium sulfate (MgSO ４ ), sodium sulfate (Na ２ SO ４ ), potassium alum (CH ３ NH ２ Al(SO ４ ) ２ ), manganese(II) chloride (MnCl ２ ), aluminum sulfate (Al ２ (SO ４ ) ３ ), aluminum chloride (AlCl ３ ), cobalt(II) chloride (CoCl ２ ), alum, NaAl(SO ４ ) ２ , sodium hydroxide (NaOH), and a salt selected from the group consisting of combinations thereof, the composition according to any one of claims 1 to 5.

7. The deliquescent substance is a deliquescent salt, preferably the deliquescent salt is magnesium chloride (MgCl ２ ), calcium chloride (CaCl ２ ), carnalite (KCl, MgCl ２ ), potassium carbonate (K ２ CO ３ ), anhydrous sodium acetate (CH ３ COONa), and dipotassium phosphate (K ２ HPO ４ A composition according to any one of claims 1 to 6, selected from any combination thereof.

8. The composition according to any one of claims 1 to 7, wherein the anhydrous substance comprises a vegetable oil and / or a vegetable fat and / or a hydrogenated oil and / or a vegetable wax and / or a paste-like fatty compound (preferably a vegetable paste-like fatty compound).

9. The composition according to any one of claims 1 to 8, wherein the viable microorganisms are freeze-dried microorganisms.

10. The composition according to any one of claims 1 to 9, wherein the viable microorganisms are bacteria or a mixture of bacterial strains.

11. The composition according to any one of claims 1 to 10, wherein the microorganism is freeze-dried and dispersed in the composition as freeze-dried crystals with a diameter of less than 100 μm.

12. Based on the total weight of the composition, - 50% to 99.5% by weight, preferably 60% to 99% by weight, of at least one anhydrous substance preferably selected from vegetable oils, vegetable waxes, vegetable paste-like fatty compounds and mixtures thereof, - At least one viable microorganism in an amount of -0.001% to 20% by weight, preferably 0.005% to 10% by weight, preferably 0.01% to 5% by weight, -0.2% to 2% by weight, preferably 0.2% to 1% by weight, at least one deliquescent substance, - Depending on the case, at least one antioxidant in an amount of 0.01% to 2% by weight, preferably 0.02% to 1% by weight, A composition according to any one of claims 1 to 11, comprising:

13. The composition according to any one of claims 1 to 12, wherein the anhydrous composition is anhydrous or essentially anhydrous, and its water content is less than 3% (w / w), for example less than 2% (w / w), for example less than 1% (w / w), for example less than 0.5% (w / w), for example less than 0.1% (w / w), for example less than 0.05% (w / w), for example less than 0.01% (w / w) relative to the anhydrous composition.

14. Use of the composition according to any one of claims 1 to 13 in the skin, mucous membrane, or reproductive organs of a mammal.

15. A composition comprising a topical anhydrous composition according to any one of claims 1 to 10 in a cosmetic, preventive medicine, or pharmaceutical for treating a disease, functional disorder, or disability.

16. Use of hygroscopic substances to stabilize viable microorganisms in anhydrous local compositions.

17. A method for providing a local anhydrous composition comprising an anhydrous substance, at least one viable microorganism, and a deliquescent substance, wherein the deliquescent substance is subjected to a step of dehydration or partial dehydration before being mixed into the anhydrous substance that provides the anhydrous composition.

18. A method for producing an anhydrous composition, - A step of providing anhydrous material, - A step of adding a deliquescent substance such as a deliquescent salt to the anhydrous substance, A step of homogenizing a mixture of anhydrous material and deliquescent material, - Optionally, the step of cooling the molten anhydrous substance containing a deliquescent substance such as a deliquescent salt to a temperature of less than approximately 30°C, - A step of adding at least one probiotic microorganism, - The step of homogenizing the mixture to provide the anhydrous composition. Methods that include...

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