Aerosol products for hand sanitizer

Abstract

To provide an aerosol product related to a disinfectant including a lower alcohol having C1-C3, capable of exhibiting sufficient sterilization and disinfection properties when being sprayed from a spray hole of the aerosol product and adhered to fingers of a user, and suppressing fire spreading from an origin of fire, even in a place in which fire exists near a user, such as a kitchen or a dining room.SOLUTION: There is provided an aerosol product for finger disinfectant comprising: an exterior container; a finger disinfectant including 20 w / v% to 65 w / v% of a lower alcohol having C1-C3 which is stored in the exterior container; and an incombustible compressed air which is filled in the exterior container in a state of being mixed with the finger disinfectant. When the finger disinfectant is sprayed from a spray hole, the finger disinfectant has an average grain diameter of 15-150 μm at a distance of 20 cm from the spray hole, for solving problems.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to an aerosol product containing a disinfectant for killing or inactivating bacteria, mold, viruses, etc. that are attached to the hands or fingers of a user. [Background technology]

[0002] 2. Description of the Related Art Conventionally, disinfectants containing ethanol or the like as an active ingredient for killing or inactivating bacteria, mold, viruses, and the like attached to the hands or fingers of a user have been known.

[0003] For example, Patent Document 1 discloses, in Example 1, an aerosol product in which a stock solution consisting of benzalkonium chloride, 99% isopropyl alcohol, glycerin, and purified water is placed in an aerosol pressure-resistant container and carbon dioxide gas is filled as a propellant, and in Example 2, an aerosol product in which a stock solution consisting of benzalkonium chloride, 99% ethanol, and purified water is placed in an aerosol pressure-resistant container and carbon dioxide gas is filled as a propellant. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 6-327750 Summary of the Invention [Problem to be solved by the invention]

[0005] However, in the aerosol product of Patent Document 1, even if the original solution of the disinfectant itself has bactericidal properties, it is not clear whether the adhered matter has sufficient bactericidal properties when sprayed from a container and attached to the user's hands or fingers. That is, in the aerosol product of Patent Document 1, lower alcohols such as isopropyl alcohol and ethanol are blended to impart bactericidal and disinfectant properties, but because they are highly volatile, when sprayed as fine particles from the nozzle of the aerosol product, they evaporate to a certain extent before adhering to the user's hands and fingers, and there is a risk that they do not have sufficient bactericidal and disinfectant properties when attached to the hands and fingers.

[0006] In addition, in the aerosol product of Patent Document 1, when the undiluted disinfectant is sprayed from the spray nozzle and applied to the user's hands, if an excessive amount of lower alcohol such as isopropyl alcohol or ethanol is sprayed in order to provide sufficient sterilization and disinfection even if it evaporates a little during the process, such lower alcohol is a flammable liquid, and there is a risk that it will ignite and spread from the source of fire if there is a fire nearby. In particular, since the spread of COVID-19, public awareness of disinfection has increased, and disinfectants containing lower alcohols such as isopropyl alcohol and ethanol are frequently used in places where there is fire, such as kitchens and dining tables, so there are concerns about the spread of fire due to ignition caused by the use of disinfectants containing lower alcohols.

[0007] Therefore, the present invention aims to provide an aerosol product for disinfectant for hands that contains a lower alcohol having 1 to 3 carbon atoms, exhibits sufficient bactericidal and disinfecting properties when sprayed from the nozzle of the aerosol product and adheres to the user's hands, and is unlikely to spread from the source of fire even if it ignites near an open flame such as in the kitchen or on the dining table. [Means for solving the problem]

[0008] [1] That is, the present invention relates to an outer container, and a food additive composition comprising: a food additive; and a food additive composition containing 20 w / v% to 65 w / v% of a lower alcohol having 1 to 3 carbon atoms and 0.1 w / v% to 3.0 w / v% of phosphoric acid, 0.1w / v% to 3.0w / v% phosphoric acid A hand disinfectant containing a salt corresponding to the above, 0.01 w / v % to 2.0 w / v % of a quaternary ammonium salt, and water, and the hand disinfectant is mixed and filled in the outer container. nitrogen The hand disinfectant has a pH of 3.0 to 5.0 at 25° C., nitrogen The pressure is 0.10 MPa or more and less than 1.0 MPa at 35°C. When the hand sanitizer is sprayed from the nozzle, The average particle diameter at 20 cm from the spray nozzle is 21 to 104 μm. This is an aerosol product for hand disinfection that is characterized by the following. Effect of the Invention

[0011] According to the present invention, an aerosol product relating to a disinfectant containing a lower alcohol having 1 to 3 carbon atoms exhibits sufficient bactericidal and disinfecting properties when sprayed from the nozzle of the aerosol product and attached to the user's hands and fingers, and can be made to be less likely to spread from the source of fire even if the disinfectant ignites in the presence of a flame nearby, such as in the kitchen or on the dining table. [Brief description of the drawings]

[0012] [Figure 1] FIG. 2 is a central cross-sectional view of the aerosol product for hand disinfection of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] Hereinafter, the embodiment of the hand disinfectant aerosol product of the present invention will be described in detail. Note that when the notation "~" is used in the description to indicate a range, it includes both the upper and lower limits.

[0014] The outer container 1 is located at the outermost position visible to the user in the aerosol product for hand disinfectant of the present invention, and is a member that contains the hand disinfectant 2 inside. Since the inside of the outer container 1 is filled with a non-flammable compressed gas, it has pressure resistance so that it does not break below a predetermined pressure, such as metals such as aluminum alloys and synthetic resins having a predetermined thickness. In this embodiment, the outer container 1 is a hollow cylindrical container with a bottom and an opening at the top. The opening at the top is sealed by a mounting cup 3 as shown in FIG. 1. In addition, when the hand disinfectant 2 described later is acidic with a pH of 3.0 to 5.0 at 25 ° C., in order to prevent the outer container 1 from being corroded, it is preferable that the inside of the outer container 1 that comes into contact with the hand disinfectant 2 has a coating layer applied to a predetermined thickness with polyolefins such as polyethylene, polypropylene, and polyvinyl chloride, and fluororesins such as polytetrafluoroethylene.

[0015] Next, the hand disinfectant 2 contained in the outer container 1 will be described.

[0016] The lower alcohol having 1 to 3 carbon atoms in the molecule, such as methanol, ethanol, isopropyl alcohol, etc., is an alcohol having 1 to 3 carbon atoms in the molecule. By using the lower alcohol, it is possible to destroy the bacterial cell membrane or the viral envelope and to kill the virus or bacteria by coagulating proteins such as enzymes, thereby preventing harm to the human body, such as diseases caused by the bacteria or viruses.

[0017] The content of the lower alcohol having 1 to 3 carbon atoms in the hand disinfectant 2 is preferably 20 w / v% to 65 w / v%, and more preferably 25 to 63 w / v%. When the content of the lower alcohol having 1 to 3 carbon atoms is within this range, bacteria, mold, viruses, etc. can be killed or inactivated, and further, when combined with an acid, it can be more effective against viruses. The concentration is expressed as a percentage of grams (g) per 100 mL.

[0018] An acid can be added to the hand disinfectant 2 of the present invention. The acid is a component that, when present together with ethanol, a quaternary ammonium salt, or the like, destroys the capsid that protects nucleic acid, thereby promoting the penetration of ethanol, a quaternary ammonium salt, or the like into cells, and in particular enhances the efficacy of inactivating a wide range of RNA and DNA viruses, regardless of whether they are enveloped or not.

[0019] Specifically, preferred acids include organic acids such as citric acid, malic acid, acetic acid, boric acid, lactic acid, formic acid, oxalic acid, and propionic acid, and inorganic acids such as phosphoric acid and sulfuric acid. These acids may be used alone or in combination of two or more.

[0020] The content of the acid is preferably 0.1 w / v% to 3.0 w / v%, and more preferably 0.2 w / v% to 2.5 w / v%, in the hand disinfectant 2. When the content of the acid is within this range, it can be effective in inactivating viruses and killing bacteria.

[0021] In the hand disinfectant 2 of the present invention, a salt of the acid can be blended. The salt of the acid is a salt corresponding to the organic acid or inorganic acid described above. Specifically, for example, when citric acid is used as the acid, the salt is sodium citrate, potassium citrate, calcium citrate, etc., when malic acid is used, the salt is sodium malate, potassium malate, calcium malate, etc., and when phosphoric acid is used, the salt is sodium phosphate, potassium phosphate, calcium phosphate, etc. In this way, by containing a salt corresponding to the acid, the hand disinfectant 2 has a pH in a predetermined range, and even if the lower alcohol having 1 to 3 carbon atoms or water in the hand disinfectant 2 volatilizes slightly after long use, a large change in pH is suppressed, so that the user can use it in a predetermined range of liquidity.

[0022] The content of the acid salt is preferably 0.1 w / v% to 3.0 w / v%, and more preferably 0.2 w / v% to 2.5 w / v%, in the hand disinfectant 2. When the content of the acid salt is within this range, the pH of the hand disinfectant 2 can be maintained within a predetermined range.

[0023] The hand disinfectant 2 of the present invention may contain a quaternary ammonium salt. The quaternary ammonium salt is generally represented by the chemical formula N + RX - (R: alkyl group, X - As represented by the formula (I): chloride ion, etc.), it is a compound consisting of a quaternary ammonium ion and a counter anion. Specific examples of quaternary ammonium salts include benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, didecyldimethylammonium chloride, hexadodecyltrimethylammonium bromide, and tetraammonium bromide. These quaternary ammonium salts can be used alone, but two or more types may be used in combination. In this way, the inclusion of a quaternary ammonium salt makes it easier to destroy the cell membrane of bacteria, or makes it easier to destroy the envelope of enveloped RNA viruses such as coronaviruses (especially COVID-19), influenza viruses, Ebola viruses, and human immunodeficiency viruses, and enveloped DNA viruses such as herpes viruses and smallpox viruses, thereby making it possible to inactivate them more easily.

[0024] The content of the quaternary ammonium salt is preferably 0.01 w / v% to 2.0 w / v%, and more preferably 0.03 w / v% to 1.0 w / v%, in the hand disinfectant 2. When the content of the quaternary ammonium salt is within this range, bacterial cell membranes are more easily destroyed, and enveloped RNA and DNA viruses are more easily inactivated.

[0025] The water of the present invention is a solvent for making a lower alcohol having 1 to 3 carbon atoms, an acid, a salt of the acid, and a quaternary ammonium salt into a uniform solution. Specifically, the water is preferably water conforming to the Japanese Pharmacopoeia standard, and examples of the water include ordinary water such as tap water and well water, purified water obtained by treating ordinary water by distillation, ion exchange treatment using an ion exchange membrane, ultrafiltration treatment using an ultrafiltration membrane, or a combination thereof, and sterilized purified water obtained by sterilizing purified water by heating or the like. The blending ratio of water is the remainder excluding the lower alcohol having 1 to 3 carbon atoms, an acid, a salt of the acid, and a quaternary ammonium salt used in the present invention, and is preferably 30 w / v% to 75 w / v%, and more preferably 32 w / v% to 65 w / v%.

[0026] In addition to the above-mentioned components, the hand disinfectant 2 may contain, as necessary, polyhydric alcohols such as glycerin, propylene glycol, butylene glycol, and sorbitol, moisturizing agents such as polysaccharides or salts thereof such as hyaluronic acid and sodium hyaluronate, thickeners such as hydroxyethyl methylcellulose and hydroxypropyl methylcellulose, fragrances, colorants, etc. For example, the addition of moisturizing agents can further prevent rough skin.

[0027] The hand disinfectant 2 containing the above-mentioned components has a pH, which indicates the degree of acidity or alkalinity, of preferably 3.0 to 5.0, and more preferably 3.0 to 4.0 at 25° C. If the pH of the hand disinfectant 2 is in this range, it is effective in killing bacteria and inactivating various viruses.

[0028] When the hand disinfectant 2 thus formulated is sprayed from the nozzle 71, the average particle diameter at 20 cm from the nozzle 71 is preferably 15 to 150 μm, and more preferably 20 to 120. If the average particle diameter is within this range, when the hand disinfectant 2 is sprayed from the nozzle 71 of the aerosol product and adheres to the user's hands, it exhibits sufficient bactericidal and disinfecting properties even if the lower alcohol having 1 to 3 carbon atoms evaporates during the process, and since it does not contain an excessive amount of lower alcohol having 1 to 3 carbon atoms, it is difficult for the fire to spread from the source of the fire even if it ignites a nearby fire. The average particle diameter is preferably measured by a laser diffraction / scattering method.

[0029] The non-flammable compressed gas of the present invention is filled into the outer container 1 together with the hand disinfectant 2, and is a gas that does not ignite or burn due to a fire at normal temperatures of about 10 to 30 ° C., which are normally used, and is in a state of pressure higher than atmospheric pressure in the outer container 1. When the actuator 7 described later is pressed, the non-flammable compressed gas is discharged to the outside together with the hand disinfectant 2. Specifically, the non-flammable compressed gas is preferably at least one selected from nitrogen, carbon dioxide, nitrous oxide, helium, and argon. If the non-flammable compressed gas is one of these gases, it will not ignite even if a fire is present near the user, and the aerosol product for hand disinfectant of the present invention can be used safely.

[0030] The pressure of the non-flammable compressed gas filled in the outer container 1 together with the hand sanitizer 2 is preferably 0.10 MPa or more and less than 1.0 MPa, and preferably 0.2 MPa or more and 0.9 MPa or less, at 35° C. When the pressure of the non-flammable compressed gas is within this range, the hand sanitizer 2 is smoothly discharged together with the non-flammable compressed gas.

[0031] As shown in Fig. 1, the aerosol product is composed of an outer container 1, a hand sanitizer 2, a mounting cup 3, a stem 4, an elastic spring 5, a tube 6, an actuator 7, etc. The hand sanitizer 2 and non-flammable compressed gas contained in the outer container 1 are at a higher pressure than the outside of the outer container 1. Therefore, when the actuator 7 is pressed down, the elastic spring 5 also presses down the stem 4 against the biasing force, so that the stem hole 41 communicates with the inside of the bag body 2, and the hand sanitizer 2 and the non-flammable compressed gas are discharged to the outside from the spray nozzle 71 of the actuator 7 through the bag body 2, via the tube 6 and the stem 4. EXAMPLES

[0032] The hand disinfectant 2 of the present invention will be specifically described below. Note that the present invention is not limited to the following examples.

[0033] <Prescription 1> At room temperature of 20°C, 28.2 g of ethanol as a lower alcohol having 1 to 3 carbon atoms, 0.5 g of phosphoric acid as an acid, 0.25 g of trisodium phosphate as a salt corresponding to the acid, 0.1 g of concentrated benzalkonium chloride solution 50 as a quaternary ammonium salt (0.05 g as benzalkonium chloride), 0.2 g of glycerin as a moisturizer, 0.01 g of sodium hyaluronate (2) as another moisturizer, and purified water as the remainder were added to a 200 ml Griffin beaker and stirred to obtain a total of 100 ml of hand sanitizer.

[0034] <Prescriptions 2-5> Formulations 2 to 5 contain a lower alcohol having 1 to 3 carbon atoms as an essential component, and, if necessary, an acid, a salt corresponding to the acid, and a quaternary ammonium salt, as shown in Table 1. A total of 100 ml of hand disinfectant was obtained in the same manner as in Example 1.

[0035] [Table 1]

[0036] The performance of the aerosol product containing the hand disinfectant thus obtained was confirmed by the following evaluation methods.

[0037] [Disinfecting and disinfecting test] Regarding the bactericidal and disinfectant properties, the effectiveness of the hand disinfectant 2 sprayed from the aerosol product against Escherichia coli and Staphylococcus aureus was confirmed. Specifically, assuming that the aerosol product is sprayed on the hands when used, the hand disinfectant was sprayed with approximately 10% of the bacteria smeared on a plate medium in a petri dish at a position 20 cm away from the spray nozzle 71. 5 Various actuators 7 with different diameters of the spray nozzle 71 were pressed with a predetermined force to spray for about 1 second against each bacterium. Then, each culture medium was cultured at 35°C for about 8 hours, and the number of bacteria was measured. Those with an efficacy of 99.9% or more of the number of bacteria killed by contact with the hand disinfectant 2 relative to the initial number of bacteria smeared on the culture medium were evaluated as "◎", those with an efficacy of 99% or more but less than 99.9% were evaluated as "○", and those with an efficacy of less than 99% were evaluated as "×". At this time, "◎" and "○" were judged to be excellent as having sufficient sterilization and disinfection properties, and "×" was judged to be poor as having insufficient sterilization and disinfection properties.

[0038] In addition, the average particle diameter of the sprayed liquid was also measured at a position 20 cm away from the spray nozzle 71 of each actuator 7 using hand disinfectant 2 with a liquid temperature of 25°C. The average particle diameter of the sprayed hand disinfectant 2 was measured using a laser diffraction / scattering device for spraying (AerotracII manufactured by Microtrackbell). The results of the relationship between the average particle diameter and the bactericidal disinfection properties when the hand disinfectant 2 was sprayed are shown in Tables 2 and 3.

[0039] [Flame length test] In accordance with the test for the length of the sprayed flame in the "Voluntary Standards for the Testing and Inspection of Aerosols, etc." (revised on April 25, 2017) by the Japan Aerosol Association, an ignited burner is placed 15 cm away from the nozzle 71 of the aerosol product, and the actuator 7 is pressed down with a specified force so that the hand sanitizer 2 passes through the upper third of the burner flame, and the hand sanitizer 2 is sprayed from the nozzle 71 of the aerosol product. At this time, the burner flame is ignited, and the length of the ignition flame extending from the burner flame along the downstream direction of the spray is measured. The length of the ignition flame extending from the burner flame that was less than 5 cm was evaluated as "◎", the length of the ignition flame extending from the burner flame that was 5 cm or more but less than 20 cm was evaluated as "○", and the length of the ignition flame extending from the burner flame that was 20 cm or more was evaluated as "×". At this time, "◎" and "○" were judged to be excellent as it is difficult to spread from the source of fire, and "×" was judged to be poor as it is easy to spread from the source of fire. The results of the flame length test when Hand Sanitizer 2 was sprayed are shown in Tables 2 and 3.

[0040] As an overall evaluation based on the results of these bactericidal disinfection tests and flame length tests, for each formulation and the average particle diameter of the spray liquid at a position 20 cm away from the spray nozzle 71, those rated as "◎" or "○" in both the bactericidal disinfection test and the flame length test were rated as "○" as they can actually be used, while those rated as "×" were rated as "×" as they cannot actually be used.

[0041] [Table 2]

[0042] [Table 3]

[0043] As shown in Tables 2 and 3, among the hand disinfectants of formulas 1 to 4, those with an average particle diameter of the spray liquid of 21 to 116 μm at a position 20 cm away from the spray nozzle 71 showed bactericidal disinfection against bacteria such as E. coli and Staphylococcus aureus even if ethanol evaporated during spraying, and the length of the ignition flame extending from the burner flame, which is the source of the fire, was less than 20 cm, so it was found that it was difficult to spread even if it ignited, and it was actually usable. However, those with an average particle diameter of the spray liquid of less than 15 μm had a large surface area, so the ethanol evaporated and the bactericidal disinfection was insufficient, and those with an average particle diameter of more than 150 μm had a bactericidal disinfection property because the ethanol was difficult to volatilize, so the ignition flame was 20 cm or more long and was easy to spread when ignited, so it was difficult to actually use any of them. [Explanation of symbols]

[0044] 1. Outer packaging 2...Bag body 3. Mounting cup 4. Stem 41 Stem hole 5. Elastic spring 6...Tube 7. Actuator 71...Spray nozzle

Claims

[Claim 1] An outer container; a hand disinfectant that contains 20 w / v % to 65 w / v % of a lower alcohol having 1 to 3 carbon atoms, 0.1 w / v % to 3.0 w / v % of phosphoric acid, 0.1 w / v % to 3.0 w / v % of a salt corresponding to the phosphoric acid, 0.01 w / v % to 2.0 w / v % of a quaternary ammonium salt, and water, which are contained in the outer container; The outer container is filled with nitrogen mixed with the hand sanitizer, The hand disinfectant has a pH of 3.0 to 5.0 at 25°C; The nitrogen pressure is 0.10 MPa or more and less than 1.0 MPa at 35° C., The aerosol product for hand disinfectant is characterized in that, when the hand disinfectant is sprayed from a spray nozzle, the average particle diameter at 20 cm from the spray nozzle is 21 to 104 μm.

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