Granular composition, method for producing granular composition, and method for improving dissolution property of granular composition
By mixing Compound (I) with excipients and compressing the mixture, the dissolution rate of granular compositions is enhanced, addressing the low dissolution issue and improving medication compliance for vulnerable populations.
Patent Information
- Application Number
- JP2024194838
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2018-02-21
- Filing Date
- 2024-11-07
- Publication Date
- 2026-02-02
- Estimated Expiration
- 2039-02-20
AI Technical Summary
Existing granular compositions containing Compound (I) exhibit low dissolution rates due to the use of excipients that slow down the dissolution process, making it difficult for individuals with poor swallowing ability, such as children and elderly people, to effectively take the medication.
A method involving mixing Compound (I) with excipients like sugar alcohols, starches, and sugars, followed by compression molding, to enhance the dissolution properties of the granular composition, with specific parameters such as porosity and particle size optimization.
The method significantly improves the dissolution rate of Compound (I) in granular compositions, ensuring faster and more effective medication absorption, particularly suitable for children and elderly patients.