Tricyclic urea compounds as JAK2 V617F inhibitors

Abstract

The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Description

[Technical Field]

[0001] The present invention provides a tricyclic urea compound that modulates the activity of the JAK2 V617F variant and is useful for treating diseases associated with the JAK2 V617F variant, including cancer. [Background technology]

[0002] Janus kinase (JAK) 2 plays a crucial role in signaling by several cytokine receptors. The JAK2 V617F mutant is the most common molecular event associated with myeloproliferative neoplasms. Selective targeting of the JAK2 V617F mutant may be useful for treating various pathological conditions while omitting essential JAK2 function. This application addresses this need and other needs. [Overview of the project]

[0003] In particular, the present invention relates to the compound of formula I, [ka] With respect to the pharmaceutically acceptable salt thereof, the constituent members are defined herein.

[0004] The present invention further provides a pharmaceutical composition comprising a compound of formula I, a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

[0005] The present invention further provides a method for inhibiting the activity of the V617F variant of JAK2 kinase, comprising contacting the kinase with a compound of formula I or a pharmaceutically acceptable salt thereof.

[0006] The present invention further provides a method for treating diseases or disorders related to the expression or activity of the V617F variant of JAK2 kinase in a patient by administering to the patient a therapeutically effective amount of the compound of formula I or a pharmaceutically acceptable salt thereof.

[0007] The present invention further provides a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in any of the methods described herein.

[0008] The present invention further provides the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in any of the methods described herein.

DETAILED DESCRIPTION OF THE INVENTION

[0009] This application provides a compound of formula I,

Chemical formula

[0010] In some embodiments, R 1 H, C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl, R 1 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl is optionally selected from 1, 2, or 3 independently selected R 1A Substituting with substituents, Each R 1A These are independently D, Haro, Oxo, CN, NO2, OR a11 , SR a11 NHOR a11 , C(O)R b11 , C(O)NR c11 R d11 , C(O)NR c11 (OR a11 ), C(O)OR a11 ,OC(O)R b11 , OC(O)NR c11 R d11 , NR c11 R d11 , NR c11 NR c11 R d11 , NR c11 C(O)R b11 , NR c11C(O)OR a11 , NR c11 C(O)NR c11 R d11 , C(=NR e11 )R b11 , C(=NR e11 )NR c11 R d11 , NR c11 C(=NR e11 )NR c11 R d11 , NR c11 C(=NR e11 )R b11 , NR c11 S(O)R b11 , NR c11 S(O)NR c11 R d11 , NR c11 S(O)2R b11 , NR c11 S(O)(=NR e11 )R b11 , NR c11 S(O)2NR c11 R d11 , S(O)R b11 , S(O)NR c11 R d11 S(O)2R b11 , S(O)2NR c11 R d11 OS(O)(=NR e11 )R b11 , and OS(O)2R b11 Selected from, Each R a11 , R b11 , R c11 , and R d11 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl, R a11 , R b11 , R c11 , and R d11 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be arbitrarily selected as 1, 2, 3, 4, 5, 6, 7, or 8 independently.M Substituting with substituents, Each R e11 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl and C 2-6 Selected from Alkinil, R 2 H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A Substituting with substituents, Each R 2A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , SR a21 NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , C(=NR e21 )R b21 , C(=NR e21 )NR c21 R d21 , NR c21 C(=NR e21 )NR c21 R d21 , NR c21 C(=NR e21 )R b21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21S(O)(=NR e21 )R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , S(O)2NR c21 R d21 OS(O)(=NR e21 )R b21 OS(O)2R b21 SF5, P(O)R f21 R g21 , OP(O)(OR h21 )(OR i21 ), P(O)(OR h21 )(OR i21 ), and BR j21 R k21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B Substituting with substituents, Each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c21 and R d21 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2B Substituting with substituents, Each R b21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B Substituting with substituents, Each R e21 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f21 and R g21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h21 and R i21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j21 and R k21 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j21 and R k21 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 2B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , SR a22 NHOR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , NR c22 R d22 , NR c22 NR c22 R d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R d22 , C(=NR e22 )R b22 , C(=NR e22 )NR c22 R d22 , NR c22 C(=NR e22 )NR c22 R d22 , NR c22 C(=NR e22 )R b22 , NR c22 S(O)R b22 , NR c22 S(O)NR c22 R d22 , NR c22 S(O)2Rb22 , NR c22 S(O)(=NR e22 )R b22 , NR c22 S(O)2NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 S(O)2R b22 , S(O)2NR c22 R d22 OS(O)(=NR e22 )R b22 OS(O)2R b22 SF5, P(O)R f22 R g22 , OP(O)(OR h22 )(OR i22 ), P(O)(OR h22 )(OR i22 ), and BR j22 R k22 Selected from, R 2B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Substituting with substituents, Each R a22 , R c22 , and R d22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a22 , R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c22 and R d22 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2C Substituting with substituents, Each R b22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b22 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Substituting with substituents, Each R e22 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f22 and R g22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h22 and R i22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j22 and R k22 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j22 and R k22 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 2CThese are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , SR a23 NHOR a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , NR c23 R d23 , NR c23 NR c23 R d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R d23 , C(=NR e23 )R b23 , C(=NR e23 )NR c23 R d23 , NR c23 C(=NR e23 )NR c23 R d23 , NR c23 C(=NR e23 )R b23 , NR c23 S(O)R b23 , NR c23 S(O)NR c23 R d23 , NR c23S(O)2R b23 , NR c23 S(O)(=NR e23 )R b23 , NR c23 S(O)2NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 S(O)2R b23 , S(O)2NR c23 R d23 OS(O)(=NR e23 )R b23 , and OS(O)2R b23 Selected from, R 2C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a23 , R c23 , and R d23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a23 , R c23 , and Rd23 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c23 and R d23 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b23 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R e23 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 H, D, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , SR a3 NHOR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3(OR a3 )、C(O)OR a3 、OC(O)R b3 、OC(O)NR c3 R d3 、NR c3 R d3 、NR c3 NR c3 R d3 、NR c3 C(O)R b3 、NR c3 C(O)OR a3 、NR c3 C(O)NR c3 R d3 、C(=NR e3 )R b3 、C(=NR e3 )NR c3 R d3 、NR c3 C(=NR e3 )NR c3 R d3 、NR c3 C(=NR e3 )R b3 、NR c3 S(O)R b3 、NR c3 S(O)NR c3 R d3 、NR c3 S(O)2R b3 、NR c3 S(O)(=NR e3 )R b3 、NR c3 S(O)2NR c3 R d3 、S(O)R b3 、S(O)NR c3 R d3 、S(O)2R b3 、S(O)2NR c3 R d3 、OS(O)(=NR e3 )R b3 、OS(O)2R b3 、SF5、P(O)R f3 R g3 、OP(O)(OR h3 )(OR i3 )、P(O)(OR h3 )(OR i3 )、and BR j3R k3 Selected from, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A Substituting with substituents, Each R a3 , R c3 , and R d3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c3 and R d3 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3A Substituting with substituents, Each R b3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A Substituting with substituents, Each R e3 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f3 and R g3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h3 and R i3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j3 and R k3 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j3 and R k3 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 3A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 NHOR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NRc31 (OR a31 )、 C(O)OR a31 、 OC(O)R b31 、 OC(O)NR c31 R d31 、 NR c31 R d31 s、 NR c31 NR c31 R d31 、 NR c31 C(O)R b31 、 NR c31 C(O)OR a31 、 NR c31 C(O)NR c31 R d31 、 C(=NR e31 )R b31 、 C(=NR e31 )NR c31 R d31 、 NR c31 sC(=NR e31 )NR c31 R d31 、 NR c31 C(=NR e31 )R b31 、 NR c31 S(O)R b31 、 NR c31 S(O)NR c31 R d31 、 NRs c31 S(O)2R b31 、 NR c31 S(O)(=NR e31 [[ID=​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​j31 R k31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B Substituting with substituents, Each R a31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c31 and R d31 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3B Substituting with substituents, Each R b31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B Substituting with substituents, Each R e31 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f31 and R g31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h31 and R i31 H and C are independent of each other. 1-6 Alkyl, C 1-6Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j31 and R k31 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j31 and R k31 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 3B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , SR a32 NHOR a32 , C(O)R b32 , C(O)NRc32 R d32 、C(O)NR c32 (OR a32 )、C(O)OR a32 、OC(O)R b32 、OC(O)NR c32 R d32 、NR c32 R d32 、NR c32 NR c32 R d32 、NR c32 C(O)R b32 、NR c32 C(O)OR a32 、NR c32 C(O)NR c32 R d32 、C(=NR e32 )R b32 、C(=NR e32 )NR c32 R d32 、NR c32 C(=NR e32 )NR c32 R d32 、NR c32 C(=NR e32 )R b32 、NR c32 S(O)R b32 、NR c32 S(O)NR c32 R d32 、NR c32 S(O)2R b32 、NR c32 S(O)(=NR e32 )R b32 、NR c32 S(O)2NR c32 R d32 、S(O)R b32 、S(O)NR c32 R d32 、S(O)2R b32 、S(O)2NR c32 R d32 、OS(O)(=NR e32 )R b32 、OS(O)2R b32 、SF5、P(O)R f32 R g32 、OP(O)(OR h32 )(OR i32 )、P(O)(ORh32 )(OR i32 ), and BR j32 R k32 Selected from, R 3B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl group can be optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R groups. 3C Substituting with substituents, Each R a32 , R c32 , and R d32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a32 , R c32 , and R d32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c32 and R d32 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3C Substituting with substituents, Each R b32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C Substituting with substituents, Each R e32 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f32 and R g32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h32 and R i32 H and C are independent of each other. 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j32 and R k32 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j32 and R k32 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 3C These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33 , SR a33 NHOR a33 , C(O)R b33 , C(O)NR c33 R d33, C(O)NR c33 (OR a33 ), C(O)OR a33 ,OC(O)R b33 , OC(O)NR c33 R d33 , NR c33 R d33 , NR c33 NR c33 R d33 , NR c33 C(O)R b33 , NR c33 C(O)OR a33 , NR c33 C(O)NR c33 R d33 , C(=NR e33 )R b33 , C(=NR e33 )NR c33 R d33 , NR c33 C(=NR e33 )NR c33 R d33 , NR c33 C(=NR e33 )R b33 , NR c33 S(O)R b33 , NR c33 S(O)NR c33 R d33 , NR c33 S(O)2R b33 , NR c33 S(O)(=NR e33 )R b33 , NR c33 S(O)2NR c33 R d33 , S(O)R b33 , S(O)NR c33 R d33 S(O)2R b33 , S(O)2NR c33 R d33 OS(O)(=NR e33 )R b33 , and OS(O)2R b33 Selected from, R 3C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a33 , R c33 , and R d33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a33 , R c33 , and R d33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c33 and R d33These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R e33 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 NHOR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)NR c4 (OR a4 ), C(O)OR a4 ,OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4 , NR c4 NR c4 R d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , C(=NR e4 )R b4 , C(=NR e4 )NR c4 Rd4 , NR c4 C(=NR e4 )NR c4 R d4 , NR c4 C(=NR e4 )R b4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O)2R b4 , NR c4 S(O)(=NR e4 )R b4 , NR c4 S(O)2NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , S(O)2NR c4 R d4 OS(O)(=NR e4 )R b4 OS(O)2R b4 SF5, P(O)R f4 R g4 , OP(O)(OR h4 )(OR i4 ), P(O)(OR h4 )(OR i4 ), and BR j4 R k4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4A Substituting with substituents, Each R a4 , R c4 , and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a4 , R c4 , and R d4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c4 and R d4These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4A Substituting with substituents, Each R b4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4A Substituting with substituents, Each R e4 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f4 and R g4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h4 and R i4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C1-6 Selected from alkyl-, Each R j4 and R k4 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j4 and R k4 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 4A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a41 , SR a41 NHOR a41 , C(O)R b41 , C(O)NR c41 R d41 , C(O)NR c41 (OR a41 ), C(O)OR a41 ,OC(O)R b41 , OC(O)NR c41 R d41 , NR c41 R d41 , NR c41 NR c41 R d41 , NR c41 C(O)R b41 , NR c41C(O)OR a41 , NR c41 C(O)NR c41 R d41 , C(=NR e41 )R b41 , C(=NR e41 )NR c41 R d41 , NR c41 C(=NR e41 )NR c41 R d41 , NR c41 C(=NR e41 )R b41 , NR c41 S(O)R b41 , NR c41 S(O)NR c41 R d41 , NR c41 S(O)2R b41 , NR c41 S(O)(=NR e41 )R b41 , NR c41 S(O)2NR c41 R d41 , S(O)R b41 , S(O)NR c41 R d41 S(O)2R b41 , S(O)2NR c41 R d41 OS(O)(=NR e41 )R b41 OS(O)2R b41 SF5, P(O)R f41 R g41 , OP(O)(OR h41 )(OR i41 ), P(O)(OR h41 )(OR i41 ), and BR j41 R k41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4B Substituting with substituents, Each R a41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a41 , R c41 , and R d41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c41 and Rd41 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4B Substituting with substituents, Each R b41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4B Substituting with substituents, Each R e41 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f41 and R g41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h41 and R i41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j41 and R k41 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Is it selected from haloalkoxys? Alternatively, any R bonded to the same B atom j41 and R k41 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 4B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a42 , SR a42 NHOR a42 , C(O)R b42 , C(O)NR c42 R d42 , C(O)NR c42 (OR a42 ), C(O)OR a42 ,OC(O)R b42 , OC(O)NR c42 R d42 , NR c42 R d42 , NR c42 NR c42 R d42 , NR c42C(O)R b42 , NR c42 C(O)OR a42 , NR c42 C(O)NR c42 R d42 , C(=NR e42 )R b42 , C(=NR e42 )NR c42 R d42 , NR c42 C(=NR e42 )NR c42 R d42 , NR c42 C(=NR e42 )R b42 , NR c42 S(O)R b42 , NR c42 S(O)NR c42 R d42 , NR c42 S(O)2R b42 , NR c42 S(O)(=NR e42 )R b42 , NR c42 S(O)2NR c42 R d42 , S(O)R b42 , S(O)NR c42 R d42 S(O)2R b42 , S(O)2NR c42 R d42 OS(O)(=NR e42 )R b42 OS(O)2R b42 SF5, P(O)R f42 R g42 , OP(O)(OR h42 )(OR i42 ), P(O)(OR h42 )(OR i42 ), and BR j42 R k42 Selected from, R 4B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4C Substituting with substituents, Each R a42 , R c42 , and R d42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a42 , R c42 , and R d42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c42 and R d42 These, together with the N atoms to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group consists of 1, 2, 3, or 4 independently selected R atoms. 4C They are arbitrarily substituted with substituents, Each R b42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 4C Substituting with substituents, Each R e42 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R f42 and R g42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R h42 and R i42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R j42 and R k42 OH and C are independent of each other. 1-6 Alkoxy, and C 1-6 Selected from haloalkoxys, Alternatively, any R bonded to the same B atom j42 and R k42 These, together with the B atom to which they are bonded, optionally become C 1-6 Alkyl and C 1-6 Form a 5 or 6-membered heterocycloalkyl group substituted with 1, 2, 3, or 4 substituents independently selected from the haloalkyl group. Each R 4C These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a43 , SR a43 NHOR a43 , C(O)R b43 , C(O)NR c43 R d43 , C(O)NR c43 (OR a43 ), C(O)OR a43 ,OC(O)R b43 , OC(O)NR c43 R d43 , NR c43 R d43 , NR c43 NR c43 R d43 , NR c43 C(O)R b43 , NRc43 C(O)OR a43 , NR c43 C(O)NR c43 R d43 , C(=NR e43 )R b43 , C(=NR e43 )NR c43 R d43 , NR c43 C(=NR e43 )NR c43 R d43 , NR c43 C(=NR e43 )R b43 , NR c43 S(O)R b43 , NR c43 S(O)NR c43 R d43 , NR c43 S(O)2R b43 , NR c43 S(O)(=NR e43 )R b43 , NR c43 S(O)2NR c43 R d43 , S(O)R b43 , S(O)NR c43 R d43 S(O)2R b43 , S(O)2NR c43 R d43 OS(O)(=NR e43 )R b43 , and OS(O)2R b43 Selected from, R 4C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a43 , R c43 , and R d43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a43 , R c43 , and R d43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c43 and R d43 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R e43 These are independently H, OH, CN, and C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, Each R M These are independently H, D, OH, halo, oxo, CN, C(O)OH, NH2, NO2, SF5, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl groups.

[0011] In some embodiments, R 1 H, C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinir, R 2 H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A Substituting with substituents, Each R 2A These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NRc21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Substituting with substituents, Each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c21 and R d21 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2B Substituting with substituents, Each R b21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Substituting with substituents, Each R 2B These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , NR c22 R d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R d22 , NR c22 S(O)R b22 , NR c22 S(O)NR c22 R d22 , NR c22 S(O)2Rb22 , NR c22 S(O)2NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 S(O)2R b22 , and S(O)2NR c22 R d22 Selected from, R 2B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2C Substituting with substituents, Each R a22 , R c22 , and R d22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a22 , R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenil, C2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c22 and R d22 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2C Substituting with substituents, Each R b22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b22 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Substituting with substituents, Each R 2C These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , SR a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , NR c23 R d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R d23 , NR c23 S(O)R b23 , NR c23 S(O)NR c23 Rd23 , NR c23 S(O)2R b23 , NR c23 S(O)2NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 S(O)2R b23 , and S(O)2NR c23 R d23 Selected from, R 2C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a23 , R c23 , and R d23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a23 , R c23 , and R d23 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c23 and R d23 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b23 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, R 3 H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3 (OR a3 ), C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3 , NR c3 S(O)R b3 , NR c3 S(O)NR c3 R d3 , NR c3 S(O)2R b3 , NR c3 S(O)2NR c3 R d3 , S(O)R b3 , S(O)NR c3 Rd3 S(O)2R b3 , and S(O)2NR c3 R d3 Selected from, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R a3 , R c3 , and R d3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c3 and R d3 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3A Substituting with substituents, Each R b3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R 3A These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NR c31 (OR a31 ), C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , NR c31 R d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R d31 , NR c31 S(O)R b31 , NR c31 S(O)NR c31 R d31 , NR c31 S(O)2R b31 , NR c31 S(O)2NR c31 R d31 , S(O)R b31, S(O)NR c31 R d31 S(O)2R b31 , and S(O)2NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R a31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c31 and R d31 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3B Substituting with substituents, Each R b31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R 3B These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)NR c32 (OR a32 ), C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , NR c32 R d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R d32 , NR c32 S(O)R b32 , NR c32 S(O)NR c32 R d32 , NR c32 S(O)2R b32 , NR c32 S(O)2NRc32 R d32 , S(O)R b32 , S(O)NR c32 R d32 S(O)2R b32 , and S(O)2NR c32 R d32 Selected from, R 3B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 3C Substituting with substituents, Each R a32 , R c32 , and R d32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a32 , R c32 , and R d32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c32 and R d32 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3C Substituting with substituents, Each R b32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3C Substituting with substituents, Each R 3C These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33 , SR a33 , C(O)R b33 , C(O)NR c33 R d33 , C(O)NR c33 (OR a33 ), C(O)OR a33 ,OC(O)R b33 , OC(O)NR c33 R d33 , NR c33 R d33 , NR c33 C(O)R b33 , NR c33 C(O)OR a33 , NR c33 C(O)NR c33 R d33 , NR c33 S(O)R b33 , NR c33 S(O)NR c33 R d33 , NR c33 S(O)2R b33 , NR c33 S(O)2NR c33 Rd33 , S(O)R b33 , S(O)NR c33 R d33 S(O)2R b33 , and S(O)2NR c33 R d33 Selected from, R 3C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a33 , R c33 , and R d33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a33 , R c33 , and R d33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c33 and R d33 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)NR c4 (OR a4 ), C(O)OR a4 ,OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O)2R b4 , NR c4 S(O)2NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 1-6Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Substituting with substituents, Each R a4 , R c4 , and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a4 , R c4 , and R d4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c4 and R d4 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4A Substituting with substituents, Each R b4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4ASubstituting with substituents, Each R 4A These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a41 , SR a41 , C(O)R b41 , C(O)NR c41 R d41 , C(O)NR c41 (OR a41 ), C(O)OR a41 ,OC(O)R b41 , OC(O)NR c41 R d41 , NR c41 R d41 , NR c41 C(O)R b41 , NR c41 C(O)OR a41 , NR c41 C(O)NR c41 R d41 , NR c41 S(O)R b41 , NR c41 S(O)NR c41 R d41 , NR c41 S(O)2R b41 , NR c41 S(O)2NR c41 R d41 , S(O)R b41 , S(O)NR c41 R d41 S(O)2R b41 , and S(O)2NR c41 R d41 Selected from, R4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Substituting with substituents, Each R a41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a41 , R c41 , and R d41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c41 and R d41 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4B Substituting with substituents, Each R b41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Substituting with substituents, Each R 4B These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a42 , SR a42 , C(O)R b42 , C(O)NR c42 R d42 , C(O)NR c42 (OR a42 ), C(O)OR a42 ,OC(O)R b42 , OC(O)NR c42 R d42 , NR c42 R d42 , NR c42 C(O)R b42 , NR c42 C(O)OR a42 , NR c42 C(O)NR c42 R d42 , NR c42 S(O)R b42 , NR c42 S(O)NR c42 R d42 , NR c42 S(O)2R b42 , NR c42 S(O)2NR c42 R d42 , S(O)R b42 , S(O)NR c42 R d42 S(O)2R b42, and S(O)2NR c42 R d42 Selected from, R 4B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Substituting with substituents, Each R a42 , R c42 , and R d42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a42 , R c42 , and R d42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c42 and R d42 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4C Substituting with substituents, Each R b42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Substituting with substituents, Each R 4C These are independently: Halo, Oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a43 , SR a43 , C(O)R b43 , C(O)NR c43 R d43 , C(O)NR c43 (OR a43 ), C(O)OR a43 ,OC(O)R b43 , OC(O)NR c43 R d43 , NR c43 R d43 , NR c43 C(O)R b43 , NR c43 C(O)OR a43 , NR c43 C(O)NR c43 R d43 , NR c43 S(O)R b43 , NR c43 S(O)NR c43 R d43 , NR c43 S(O)2R b43 , NR c43 S(O)2NR c43 R d43 , S(O)R b43 , S(O)NR c43 R d43 S(O)2Rb43 , and S(O)2NR c43 R d43 Selected from, R 4C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a43 , R c43 , and R d43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a43 , R c43 , and R d43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c43 and R d43 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R MThese are independently H, OH, halo, oxo, CN, C(O)OH, NH2, NO2, SF5, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl groups.

[0012] In some embodiments, R 1 H, C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinir, R 2 H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A Substituting with substituents, Each R 2A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Substituting with substituents, Each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a21 , R c21, and R d21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c21 and R d21 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2B Substituting with substituents, Each R b21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b21 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B Substituting with substituents, Each R 2B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , SR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , NR c22 R d22 , NR c22 C(O)R b22 , NR c22 C(O)OR a22 , NR c22 C(O)NR c22 R d22 , NR c22 S(O)R b22, NR c22 S(O)NR c22 R d22 , NR c22 S(O)2R b22 , NR c22 S(O)2NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 S(O)2R b22 , and S(O)2NR c22 R d22 Selected from, R 2B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2C Substituting with substituents, Each R a22 , R c22 , and R d22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a22, R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c22 and R d22 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 2C Substituting with substituents, Each R b22 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b22 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Substituting with substituents, Each R 2C These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , SR a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , NR c23 R d23 , NR c23 C(O)R b23 , NR c23 C(O)OR a23 , NR c23 C(O)NR c23 R d23 , NR c23 S(O)R b23 , NRc23 S(O)NR c23 R d23 , NR c23 S(O)2R b23 , NR c23 S(O)2NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 S(O)2R b23 , and S(O)2NR c23 R d23 Selected from, R 2C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a23 , R c23 , and R d23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a23 , R c23 , and R d23 C 1-6 Alkyl, C 2-6Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c23 and R d23 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b23 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b23 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, R 3 D, H, Haro, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , SR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3 (OR a3 ), C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , NR c3 R d3 , NR c3 C(O)R b3 , NR c3 C(O)OR a3 , NR c3 C(O)NR c3 R d3 , NR c3 S(O)R b3 , NR c3 S(O)NR c3 R d3 , NR c3 S(O)2R b3 , NR c3 S(O)2NR c3 R d3 , S(O)Rb3 , S(O)NR c3 R d3 S(O)2R b3 , and S(O)2NR c3 R d3 Selected from, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R a3 , R c3 , and R d3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c3 and R d3 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3A Substituting with substituents, Each R b3 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R 3A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NR c31 (OR a31 ), C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , NR c31 R d31 , NR c31 C(O)R b31 , NR c31 C(O)OR a31 , NR c31 C(O)NR c31 R d31 , NR c31 S(O)R b31 , NR c31 S(O)NR c31 R d31 , NR c31 S(O)2R b31 , NR c31 S(O)2NRc31 R d31 , S(O)R b31 , S(O)NR c31 R d31 S(O)2R b31 , and S(O)2NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R a31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c31 and R d31 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3B Substituting with substituents, Each R b31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b31 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R 3B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)NR c32 (OR a32 ), C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , NR c32 R d32 , NR c32 C(O)R b32 , NR c32 C(O)OR a32 , NR c32 C(O)NR c32 R d32 , NR c32 S(O)R b32 , NR c32 S(O)NR c32 R d32 , NR c32 S(O)2R b32 , NRc32 S(O)2NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 S(O)2R b32 , and S(O)2NR c32 R d32 Selected from, R 3B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 3C Substituting with substituents, Each R a32 , R c32 , and R d32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a32 , R c32 , and R d32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c32 and R d32 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 3C Substituting with substituents, Each R b32 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b32 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3C Substituting with substituents, Each R 3C These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33 , SR a33 , C(O)R b33 , C(O)NR c33 R d33 , C(O)NR c33 (OR a33 ), C(O)OR a33 ,OC(O)R b33 , OC(O)NR c33 R d33 , NR c33 R d33 , NR c33 C(O)R b33 , NR c33 C(O)OR a33 , NR c33 C(O)NR c33 R d33 , NR c33 S(O)R b33 , NR c33 S(O)NR c33 R d33 , NR c33 S(O)2R b33 , NR c33S(O)2NR c33 R d33 , S(O)R b33 , S(O)NR c33 R d33 S(O)2R b33 , and S(O)2NR c33 R d33 Selected from, R 3C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a33 , R c33 , and R d33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a33 , R c33 , and R d33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c33 and R d33 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b33 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b33 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected RM Substituting with substituents, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)NR c4 (OR a4 ), C(O)OR a4 ,OC(O)R b4 , OC(O)NR c4 R d4 , NR c4 R d4 , NR c4 C(O)R b4 , NR c4 C(O)OR a4 , NR c4 C(O)NR c4 R d4 , NR c4 S(O)R b4 , NR c4 S(O)NR c4 R d4 , NR c4 S(O)2R b4 , NR c4 S(O)2NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Substituting with substituents, Each R a4 , R c4 , and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a4 , R c4 , and R d4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c4 and R d4 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4A Substituting with substituents, Each R b4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Substituting with substituents, Each R 4A These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a41 , SR a41 , C(O)R b41 , C(O)NR c41 R d41 , C(O)NR c41 (OR a41 ), C(O)OR a41 ,OC(O)R b41 , OC(O)NR c41 R d41 , NR c41 R d41 , NR c41 C(O)R b41 , NR c41 C(O)OR a41 , NR c41 C(O)NR c41 R d41 , NR c41 S(O)R b41 , NR c41 S(O)NR c41 R d41 , NR c41 S(O)2R b41 , NR c41 S(O)2NR c41 R d41 , S(O)R b41 , S(O)NR c41 R d41 S(O)2R b41, and S(O)2NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Substituting with substituents, Each R a41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a41 , R c41 , and R d41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c41 and R d41 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4B Substituting with substituents, Each R b41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b41 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Substituting with substituents, Each R 4B These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a42 , SR a42 , C(O)R b42 , C(O)NR c42 R d42 , C(O)NR c42 (OR a42 ), C(O)OR a42 ,OC(O)R b42 , OC(O)NR c42 R d42 , NR c42 R d42 , NR c42 C(O)R b42 , NR c42 C(O)OR a42 , NR c42 C(O)NR c42 R d42 , NR c42 S(O)R b42 , NR c42 S(O)NR c42 R d42 , NR c42 S(O)2R b42 , NR c42 S(O)2NR c42 R d42 , S(O)R b42 , S(O)NRc42 R d42 S(O)2R b42 , and S(O)2NR c42 R d42 Selected from, R 4B C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Substituting with substituents, Each R a42 , R c42 , and R d42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a42 , R c42 , and R d42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c42 and R d42 These, together with the N atom to which they are bonded, form a 5-10 member heteroaryl or 4-10 member heterocycloalkyl group, and the 5-10 member heteroaryl or 4-10 member heterocycloalkyl group can optionally consist of 1, 2, 3, or 4 independently selected R atoms. 4C Substituting with substituents, Each R b42 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b42 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4C Substituting with substituents, Each R 4C These are D, Halo, Oxo, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-7 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a43 , SR a43 , C(O)R b43 , C(O)NR c43 R d43 , C(O)NR c43 (OR a43 ), C(O)OR a43 ,OC(O)R b43 , OC(O)NR c43 R d43 , NR c43 R d43 , NR c43 C(O)R b43 , NR c43 C(O)OR a43 , NR c43 C(O)NR c43 R d43 , NR c43 S(O)R b43 , NR c43 S(O)NR c43 R d43 , NR c43 S(O)2R b43 , NR c43 S(O)2NR c43 R d43 , S(O)Rb43 , S(O)NR c43 R d43 S(O)2R b43 , and S(O)2NR c43 R d43 Selected from, R 4C C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each R a43 , R c43 , and R d43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R a43 , R c43 , and R d43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Is it substituted with a substituent? Alternatively, any R bonded to the same N atom c43 and R d43 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-7 member heterocycloalkyl group, and the 5-6 member heteroaryl or 4-7 member heterocycloalkyl group optionally consists of 1, 2, 3, or 4 independently selected R atoms. M Substituting with substituents, Each R b43 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R b43 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-7 Cycloalkyl, 5-6 member heteroaryl, 4-7 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-7 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R M Substituting with substituents, Each RM These are independently H, D, OH, halo, oxo, CN, C(O)OH, NH2, NO2, SF5, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl groups.

[0013] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 1A It is substituted with a substituent.

[0014] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, or 3 independently selected R 1A It is substituted with a substituent.

[0015] Several embodiments, each R 1A They are independent: Haro, CN, NO2, OR a11 , and SR a11 Selected from.

[0016] Several embodiments, each R 1A These are independently D, Haro, CN, NO2, OR a11 , and SRa11 Selected from.

[0017] Several embodiments, each R a11 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0018] Several embodiments, each R a11 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0019] Several embodiments, each R 1A They are independent: Haro, CN, NO2, OR a11 , and SR a11 Selected from, each R a11 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0020] Several embodiments, each R 1A These are independently D, Haro, CN, NO2, OR a11 , and SR a11 Selected from, each R a11 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0021] Several embodiments, each R 1A is OR a11 That is the case.

[0022] Several embodiments, each R 1A is OR a11 And each R a11 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0023] Several embodiments, each R 1A It is OH.

[0024] Several embodiments, each R 1A They are independent: Haro, CN, NO2, OR a11 , and SR a11 Selected from, each R a11 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0025] Several embodiments, each R 1A These are independently D, Haro, CN, NO2, OR a11 , and SR a11 Selected from, each R a11 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0026] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 The alkyl group is optionally substituted with an OH group.

[0027] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 The alkyl group is optionally substituted with an OH group, and R 1 One or more hydrogen atoms are optionally replaced by deuterium atoms.

[0028] In some embodiments, R 1 This is selected from H, methyl, ethyl, and hydroxyethyl.

[0029] In some embodiments, R 1 H is H.

[0030] In some embodiments, R 1 It is either methyl or ethyl.

[0031] In some embodiments, R 1 It is methyl.

[0032] In some embodiments, R 1 It is hydroxyethyl.

[0033] In some embodiments, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0034] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C1-6 Alkyl-, and (6-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (6-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0035] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0036] In some embodiments, R 2 H, C1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, (5-10 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, and (5-10 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0037] In some embodiments, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, (5-10 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-10 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0038] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0039] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0040] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 2A It is substituted with a substituent.

[0041] In some embodiments, R 2 H, C 1-6 Alkyl, phenyl, C 3-10Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, phenyl, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, and (5-6 member heteroaryl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 2A It is substituted with a substituent.

[0042] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , C(=NR e21 )R b21 , C(=NR e21 )NR c21 R d21 , NR c21 C(=NR e21 )NR c21 R d21 , NRc21 C(=NR e21 )R b21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)(=NR e21 )R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , S(O)2NR c21 R d21 OS(O)(=NR e21 )R b21 OS(O)2R b21 SF5, P(O)R f21 R g21 , OP(O)(OR h21 )(OR i21 ), P(O)(OR h21 )(OR i21 ), and BR j21 R k21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0043] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 NHOR a21 , C(O)R b21 , C(O)NR c21 Rd21 、C(O)NR c21 (OR a21 )、C(O)OR a21 、OC(O)R b21 、OC(O)NR c21 R d21 、NR c21 R d21 、NR c21 NR c21 R d21 、NR c21 C(O)R b21 、NR c21 C(O)OR a21 、NR c21 C(O)NR c21 R d21 、C(=NR e21 )R b21 、C(=NR e21 )NR c21 R d21 、NR c21 C(=NR e21 )NR c21 R d21 、NR c21 C(=NR e21 )R b21 、NR c21 S(O)R b21 、NR c21 S(O)NR c21 R d21 、NR c21 S(O)2R b21 、NR c21 S(O)(=NR e21 )R b21 、NR c21 S(O)2NR c21 R d21 、S(O)R b21 、S(O)NR c21 R d21 、S(O)2R b21 、S(O)2NR c21 R d21 、OS(O)(=NR e21 )R b21 、OS(O)2R b21 、SF5、P(O)R f21 R g21 、OP(O)(OR h21 )(OR i21 )、P(O)(OR h21 )(ORi21 ), and BR j21 R k21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0044] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , C(=NR e21 )R b21 , C(=NR e21 )NR c21 R d21 , NR c21 C(=NR e21 )NR c21 R d21 , NR c21 C(=NR e21 )R b21 , NR c21 S(O)Rb21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)(=NR e21 )R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , S(O)2NR c21 R d21 OS(O)(=NR e21 )R b21 OS(O)2R b21 SF5, P(O)R f21 R g21 , OP(O)(OR h21 )(OR i21 ), P(O)(OR h21 )(OR i21 ), and BR j21 R k21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0045] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21、OC(O)R b21 、OC(O)NR c21 R d21 、NO c21 R d21 、NO c21 NR c21 R d21 、NO c21 C(O)R b21 、NO c21 C(O)OR a21 、NO c21 C(O)NR c21 R d21 、C(=NR e21 )R b21 、C(=NR e21 )NR c21 R d21 、NO c21 C(=NR e21 )NR c21 R d21 、NO c21 C(=NR e21 )R b21 、NO c21 SOUTH b21 、NO c21 S(O)NR c21 R d21 、NO c21 S(O)2R b21 、NO c21 S(O)(=NR) e21 )R b21 、NO c21 S(O)2NR c21 R d21 ,SOUTH b21 、S(O)NR c21 R d21 、S(O)2R b21 、S(O)2NR c21 R d21 、OS(O)(=NR e21 )R b21 、OS(O)2R b21 、SF5、P(O)R f21 R g21 、OP(O)(OR) h21 )(OR i21 )、P(O)(OR h21 )(OR i21 )、&&BR j21 R k21 R 2AC 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0046] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6Alkinyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0047] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2BIt is substituted with a substituent.

[0048] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0049] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , NR c21 C(O)NR c21 R d21 , NR c21 S(O)R b21 , NR c21 S(O)NR c21 R d21 , NR c21 S(O)2R b21 , NR c21 S(O)2NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0050] Several embodiments, each R 2A They are independent, Hello, C 1-6Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0051] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 , S(O)Rb21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0052] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)OR a21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0053] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, ORa21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0054] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)OR a21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0055] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0056] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NRc21 C(O)OR a21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group is optionally selected from one or two independently chosen R groups. 2B It is substituted with a substituent.

[0057] Several embodiments, each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from one or two independently selected R 2B It is substituted with a substituent.

[0058] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, ORa21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)OR a21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group is optionally selected from one or two independently chosen R groups. 2B It is substituted with a substituent.

[0059] Several embodiments, each R 2A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from one or two independently selected R 2B It is substituted with a substituent.

[0060] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , C(O)OR a21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , and S(O)2R b21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0061] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , C(O)OR a21 , NR c21 C(O)R b21 , NR c21 C(O)OR a21 , and S(O)2R b21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group is optionally selected from one or two independently chosen R groups. 2B It is substituted with a substituent.

[0062] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , C(O)OR a21 , NR c21 C(O)R b21 , NRc21 C(O)OR a21 , and S(O)2R b21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Cycloalkyl is optionally selected from 1 or 2 independently selected R 2B It is substituted with a substituent.

[0063] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , and NR c21 C(O)R b21 Selected from.

[0064] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , C(O)OR a21 , NR c21 C(O)OR a21 , and S(O)2R b21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0065] Several embodiments, each R 2A C 1-6 Alkyl, OR a21 , and C(O)NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0066] Several embodiments, each R 2A C 1-6 Alkyl, C 3-10 Cycloalkyl, OR a21 , C(O)NR c21 R d21 , C(O)OR a21 , NR c21 C(O)OR a21 , and S(O)2R b21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Each cycloalkyl group is optionally selected from one or two independently chosen R groups. 2B It is substituted with a substituent.

[0067] Several embodiments, each R 2A C 1-6 Alkyl, OR a21 , and C(O)NR c21 R d21 Selected from, R 2A C 1-6 Alkyl is optionally selected from one or two independently selected R 2B It is substituted with a substituent.

[0068] Several embodiments, each R 2A C 1-6 Alkyl, OR a21 , and C(O)NR c21 R d21 Selected from.

[0069] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from Alkinyl, R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B Is it substituted with a substituent? Alternatively, any R c21 and R d21 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group. Each R b21 H and C are independent of each other. 1-6 Selected from alkyl groups, C 1-6 Each alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0070] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Selected from alkyl groups, Alternatively, any R c21 and R d21 These, together with the N atom to which they are bonded, form a 4-6 member heterocycloalkyl group. Each R b21 H and C are independent of each other. 1-6 Selected from alkyl groups, C 1-6 Each alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B It is substituted with a substituent.

[0071] Several embodiments, each R a21 , R b21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from Alkinyl, R a21 , R b21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0072] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from Alkinyl, R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0073] In some embodiments, any R c21 and R d21 These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group.

[0074] Several embodiments, each R a21 , R b21 , R c21 , and R d21 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0075] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0076] In some embodiments, any R c21 and R d21 These, together with the N atom to which they are bonded, form a 4- to 6-membered heterocycloalkyl group.

[0077] Several embodiments, each R a21 , R b21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from Alkinyl, R a21 , R b21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B It is substituted with a substituent.

[0078] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from Alkinyl, R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2B Is it substituted with a substituent? Alternatively, any R c21 and R d21 However, together with the N atom to which they are bonded, they form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group.

[0079] Several embodiments, each R a21 , R b21 , R c21 , and R d21 H and C are independent of each other. 1-6 Selected from alkyl groups, Alternatively, any R c21 and Rd21 These, together with the N atom to which they are bonded, form a 4- to 6-membered heterocycloalkyl group.

[0080] Several embodiments, each R a21 , R c21 , and R d21 H and C are independent of each other. 1-6 Selected from alkyl groups, Alternatively, any R c21 and R d21 These, together with the N atom to which they are bonded, form a 4- to 6-membered heterocycloalkyl group.

[0081] Several embodiments, each R 2B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, CN, and NO2, R 2B C 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Each alkynyl can be optionally selected as 1, 2, 3, or 4 independently. 2C It is substituted with a substituent.

[0082] Several embodiments, each R 2C C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, CN, and NO2.

[0083] Several embodiments, each R 2C This is CN.

[0084] Several embodiments, each R 2B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, CN, and NO2, C1-6 Alkyl and C 2-6 Each alkenyl is optionally replaced by a CN.

[0085] Several embodiments, each R 2B It is CN or cyanomethyl.

[0086] Several embodiments, each R 2B This is CN.

[0087] Several embodiments, each R 2B It is cyanomethyl.

[0088] Several embodiments, each R 2A R is independently selected from methyl, methoxy, cyclobutyl, ethylamide, methoxyethylamide, piperidinyl carbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl, 2A Cyclobutyl is optional, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 One or two R selected independently from alkynyl, CN, and NO2 2B Substituting with substituents, R 2B Each C 1-6 Alkyl groups are optionally substituted with cyano groups.

[0089] Several embodiments, each R 2A R is independently selected from methyl, methoxy, cyclobutyl, ethylamide, methoxyethylamide, piperidinyl carbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl, 2A Cyclobutyl is optional, C 1-6 Substituted by alkyl, R 2B C 1-6Alkyl groups are optionally substituted with cyano groups.

[0090] Several embodiments, each R 2A R is independently selected from methyl, methoxy, cyclobutyl, ethylamide, methoxyethylamide, piperidinyl carbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl, 2A The cyclobutyl group is optionally substituted with cyanomethyl.

[0091] Several embodiments, each R 2A These are independently selected from methyl, methoxy, cyanomethylcyclobutyl, ethylamide, methoxyethylamide, piperidinyl carbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl.

[0092] Several embodiments, each R 2A These are independently selected from methyl, methoxy, ethylamide, methoxyethylamide, and piperidinyl carbonyl.

[0093] Several embodiments, each R 2A These are independently selected from methyl, methoxy, and piperidinyl carbonyl.

[0094] In some embodiments, R 2The compounds are selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranil, piperidinyl, azaspiro[3.5]nonanyl, pyridyl, benzofuranil, and pyrazolylmethyl, and include cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, and bicyclo[2.2. [1]heptanyl, phenyl, tetrahydropyranil, piperidinyl, azaspiro[3.5]nonanil, pyridyl, benzofuranil, and pyrazolylmethyl are each optionally selected from methyl, cyclobutyl, methoxy, ethylamide, methoxyethylamide, piperidinylcarbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl, one or two R 2A It is substituted with R 2A Each cyclobutyl is optionally C 1-6 One R is alkyl 2B Substituting with substituents, R 2B C 1-6 Alkyl groups are optionally substituted with cyano groups.

[0095] In some embodiments, R 2The compounds are selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranil, piperidinyl, azaspiro[3.5]nonanyl, pyridyl, benzofuranil, and pyrazolylmethyl, and include cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, and bicyclo[2.2.1] Butanyl, phenyl, tetrahydropyranyl, piperidinyl, azaspiro[3.5]nonanyl, pyridyl, benzofuranyl, and pyrazolylmethyl are each optionally selected from methyl, cyanomethylcyclobutyl, methoxy, ethylamide, methoxyethylamide, piperidinylcarbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl, with one or two R selected independently from these. 2A It is substituted with the base.

[0096] In some embodiments, R 2 R is selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl, and each of cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl is optionally selected from methyl, methoxy, ethylamide, methoxyethylamide, and piperidinyl carbonyl, and one or two R 2A It is substituted with the base.

[0097] In some embodiments, R 2R is selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl, and each of cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl is optionally selected from methyl, methoxy, and piperidinyl carbonyl, and one or two R are independently selected from methyl, methoxy, and piperidinyl carbonyl. 2A It is substituted with the base.

[0098] In some embodiments, R 3 H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3AIt is substituted with a substituent.

[0099] In some embodiments, R 3 H, D, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0100] In some embodiments, R 3 H, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0101] In some embodiments, R 3 H, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3AIt is substituted with a substituent.

[0102] In some embodiments, R 3 H, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Selected from cycloalkyl, 5-10 member heteroaryl, and 4-10 member heterocycloalkyl, R 3 C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0103] In some embodiments, R 3 H, C 6-10 Ariel, C 3-10 Selected from cycloalkyl, 5-10 member heteroaryl, and 4-10 member heterocycloalkyl, R 3 C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0104] In some embodiments, R 3 H, C 2-6 Alkinyl, phenyl, C 3-6 Selected from cycloalkyl, 5-10 member heteroaryl, and 4-6 member heterocycloalkyl, R 3 Phenyl, C 3-6 Cycloalkyls, 5-10 membered heteroaryls, and 4-6 membered heterocycloalkyls are each optionally selected from 1, 2, 3, or 4 independently selected R groups. 3A It is substituted with a substituent.

[0105] In some embodiments, R 3 H, phenyl, C 3-6Selected from cycloalkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, R 3 Phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0106] In some embodiments, R 3 H, C 2-6 Alkinyl, phenyl, C 3-6 Selected from cycloalkyl, 5-10 member heteroaryl, and 4-6 member heterocycloalkyl, R 3 C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-10 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1 or 2 independently chosen R 3A It is substituted with a substituent.

[0107] In some embodiments, R 3 H, phenyl, C 3-6 Selected from cycloalkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, R 3 Phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1 or 2 independently selected R 3A It is substituted with a substituent.

[0108] Several embodiments, each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , C(O)R b31 , SR a31 SO2R b31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0109] Several embodiments, each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 SO2Rb31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0110] Several embodiments, each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , C(O)R b31 , SR a31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0111] Several embodiments, each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0112] Several embodiments, each R 3A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , C(O)R b31 , SR a31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0113] Several embodiments, each R 3A These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0114] Several embodiments, each R 3A C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, CN, OR a31 , C(O)R b31 , and SO2R b31 Selected from, R 3A C1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C 6-10 Aryl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0115] Several embodiments, each R 3A C 1-6 Alkyl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, CN, OR a31 , and SO2R b31 Selected from, R 3A C 1-6 Alkyl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C 6-10 Aryl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0116] Several embodiments, each R 3A C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, CN, C(O)R b31 SO2R b31 , and OR a31 Selected from, R 3A C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent, and each Ra31 and R b31 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0117] Several embodiments, each R 3A R is independently selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, methylcarbonyl, and methylsulfonyl, where the methyl group of methylcarbonyl is substituted with methylsulfonylphenyl. In some embodiments, each R 3A C 1-6 Alkyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, CN, SO2R b31 , and OR a31 Selected from, R 3A C 1-6 Alkyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent, and each R a31 and R b31 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0118] Several embodiments, each R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, C(O)R b31 , and OR a31 Selected from, R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0119] Several embodiments, each R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a31 Selected from, R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3BIt is substituted with a substituent.

[0120] Several embodiments, each R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, CN, C(O)R b31 , and OR a31 Selected from, R 3A C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C 6-10 Aryl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0121] Several embodiments, each R 3A C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, CN, and OR a31 Selected from, R 3A C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C 6-10 Aryl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0122] Several embodiments, each R 3A It is independently phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, CN, C(O)R b31 , and OR a31 Selected from, R 3A C 3-6Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent.

[0123] Several embodiments, each R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, CN, and OR a31 Selected from, R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent.

[0124] Several embodiments, each R a31 , R b31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from alkynyl, each R a31 , R b31 , R c31 , and R d31 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Alkinyl is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0125] Several embodiments, each R a31 , R b31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C2-6 Alkenyl and C 2-6 Selected from alkynyl, each R a31 , R b31 , R c31 , and R d31 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Alkinyl is optionally selected from one or two independently selected R 3B It is substituted with a substituent.

[0126] Several embodiments, each R a31 , R b31 , R c31 , and R d31 H and C are independent of each other. 1-6 Selected from alkyl groups, each R a31 , R b31 , R c31 , and R d31 C 1-6 Alkyl is optionally selected from one or two independently selected R 3B It is substituted with a substituent.

[0127] Several embodiments, each R a31 and R b31 H and C are independent of each other. 1-6 Selected from alkyl groups, each R a31 , R b31 , R c31 , and R d31 C 1-6 Alkyl is optionally selected from one or two independently selected R 3B It is substituted with a substituent.

[0128] Several embodiments, each R a31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0129] Several embodiments, each R a31H and C are independent of each other. 1-6 Selected from alkyl groups.

[0130] Several embodiments, each R b31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from alkynyl, each R b31 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Alkinyl is optionally selected from one or two independently selected R 3B It is substituted with a substituent.

[0131] Several embodiments, each R b31 H and C are independent of each other. 1-6 Selected from alkyl, R b31 C 1-6 Alkyl is optionally selected from one or two independently selected R 3B It is substituted with a substituent.

[0132] Several embodiments, each R b31 H and C are independent of each other. 1-6 Selected from alkyl, R b31 C 1-6 The alkyl group is optionally substituted with phenyl, and the phenyl group is optionally substituted with methylsulfonyl.

[0133] Several embodiments, each R b31 H and C are independent of each other. 1-6 Selected from alkyl, R b31 C 1-6 The alkyl group is optionally substituted with methylsulfonylphenyl.

[0134] Several embodiments, each R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C1-6 Alkyl-, CN, C(O)R b31 , and OR a31 Selected from, R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent, and each R a31 H and C are independent of each other. 1-6 Selected from alkyl groups, each R b31 H and C are independent of each other. 1-6 Selected from alkyl, R b31 C 1-6 The alkyl group is optionally substituted with methylsulfonylphenyl.

[0135] Several embodiments, each R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, CN, and OR a31 Selected from, R 3A C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 3B It is substituted with a substituent, and each R a31 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0136] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkynyl, phenyl, 4-6 member heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32, and C(O)OR a32 Selected from, R 3B Each phenyl and 4-6 member heterocycloalkyl group can be optionally selected as S(O)2R b33 It has been replaced with.

[0137] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkynyl, phenyl, 4-6 member heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 3B Each phenyl is optionally S(O)2R b33 It is replaced by each R b33 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0138] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkynyl, phenyl, 4-6 member heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 3B Each phenyl molecule is optionally substituted with methylsulfonyl.

[0139] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6Alkynyl, 4-6 membered heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from.

[0140] Several embodiments, each R 3B These are independently phenyl, 4-6 member heterocycloalkyl, CN, OR a32 , C(O)R b32 , and C(O)OR a32 Selected from, R 3B Each phenyl is optionally S(O)2R b33 It has been replaced with, Each R a32 H and C are independent of each other. 1-6 Selected from alkyl and 4-6 member heterocycloalkyl groups, Each R b32 H and C are independent of each other. 1-6 Selected from alkyl groups, Each R b33 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0141] Several embodiments, each R 3B These are independently phenyl, 4-6 member heterocycloalkyl, CN, OR a32 , C(O)R b32 , and C(O)OR a32 Selected from, R 3B Each phenyl molecule is optionally substituted with methylsulfonyl. Each R a32 H and C are independent of each other. 1-6 Selected from alkyl and 4-6 member heterocycloalkyl groups, Each R b32 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0142] Several embodiments, each R 3B These are independently 4-6 member heterocycloalkyl, CN, ORa32 , C(O)R b32 , and C(O)OR a32 Selected from, each R a32 H and C are independent of each other. 1-6 Selected from alkyl and 4-6 member heterocycloalkyl groups, each R b32 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0143] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 3B Each phenyl molecule is optionally substituted with methylsulfonyl.

[0144] Several embodiments, each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from.

[0145] Several embodiments, each R 3B These are D, Haro, and C, which are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NRc32 R d32 、 and C(O)OR a32 is selected from.

[0146] In some embodiments, each R 3B is independently selected from phenyl, CN, and C(O)OR a32 , and each phenyl of R 3B is optionally substituted with methylsulfonyl.

[0147] In some embodiments, each R 3B is independently selected from CN and C(O)OR a32 .

[0148] In some embodiments, each R a32 is independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, and C 2-6 alkynyl.

[0149] In some embodiments, each R a32 is independently selected from H and C 1-6 alkyl.

[0150] In some embodiments, each R a32 is H.

[0151] In some embodiments, each R 3B is independently selected from CN and C(O)OR a32 , and each R a32 is independently selected from H and C 1-6 alkyl.

[0152] In some embodiments, each R 3B is independently selected from phenyl, morpholinyl, CN, tetrahydropyranyloxy, methylcarbonyl, and C(O)OH.

[0153] In some embodiments, each R 3Bis independently selected from morpholinyl, CN, tetrahydropyranyloxy, methylcarbonyl, and C(O)OH.

[0154] In some embodiments, each R 3B is independently selected from CN and C(O)OH.

[0155] In some embodiments, each R 3A is independently selected from methyl, trideuteriomethyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, methylcarbonyl, and methylsulfonyl, and the methyl group of methylcarbonyl is substituted by methylsulfonylphenyl.

[0156] In some embodiments, R 3The compounds are selected from H, ethinyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanyl, thiazolyl, indazolyl, piperidinyl, and pyridyl, and are selected from ethinyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, and pi Roro[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, piperidinyl, and pyridyl are each optionally selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, methylcarbonyl, and methylsulfonyl, one or two R 3A The group is substituted, and the methyl group of methylcarbonyl is substituted with methylsulfonylphenyl.

[0157] In some embodiments, R 3The compounds are selected from H, ethinyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanyl, thiazolyl, indazolyl, piperidinyl, and pyridyl, and are selected from ethinyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2- a) Pyrazinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, piperidinyl, and pyridyl are each optionally selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, (methylsulfonylphenyl)methylcarbonyl, and methylsulfonyl, one or two R 3A It is substituted by the element.

[0158] In some embodiments, R 3The compounds are selected from H, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanyl, thiazolyl, indazolyl, and pyridyl, and include phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazo Pyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, and pyridyl each optionally contain one or two R compounds independently selected from methyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, and methylsulfonyl. 3A It is substituted by the element.

[0159] In some embodiments, R 3 R is selected from H, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, and pyridyl, and each of phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, and pyridyl is optionally selected from cyano, methoxy, cyclopropyl, cyanocyclopropyl, benzyl, and carboxybenzyl, and one or two R 3A It is substituted by the element.

[0160] In some embodiments, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0161] In some embodiments, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C 1-6 alkyl-, C 3-6 cycloalkyl-C 1-6 alkyl-, (5- to 6-membered heteroaryl)-C 1-6 alkyl-, (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 , S(O)R b4 , S(O)NR c4 R d4 , S(O)2R b4 , and S(O)2NR c4 R d4 selected from, R 4 of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, C 3-6 cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C 1-6 alkyl-, C 3-6 cycloalkyl-C 1-6 alkyl-, (5- to 6-membered heteroaryl)-C 1-6 alkyl-, and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl- is each, optionally, substituted with 1, 2, 3, or 4 independently selected R 4A substituents.

[0162] In some embodiments, R 4 is halo, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, phenyl, C 3-6 cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, phenyl-C 1-6 alkyl-, C 3-6Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0163] In some embodiments, R 4 Hello, C 2-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6Alkyl-, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 2-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0164] In some embodiments, R 4 Hello, C 2-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SRa4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 2-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0165] In some embodiments, R 4 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6Cycloalkyl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0166] In some embodiments, R 4 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0167] In some embodiments, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl group consists of one or two independently selected R groups, which are optional. 4A It is substituted with a substituent.

[0168] In some embodiments, R4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1 or 2 independently chosen R 4A It is substituted with a substituent.

[0169] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl group consists of one or two independently selected R groups, which are optional. 4A It is substituted with a substituent.

[0170] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 2-6Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1 or 2 independently chosen R 4A It is substituted with a substituent.

[0171] In some embodiments, R 4 C 2-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0172] In some embodiments, R 4 C 2-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 4AIt is substituted with a substituent.

[0173] In some embodiments, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0174] In some embodiments, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0175] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0176] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1, 2, 3, or 4 independently selected R 4A It is substituted with a substituent.

[0177] In some embodiments, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl group consists of one or two independently selected R groups, which are optional. 4A It is substituted with a substituent.

[0178] In some embodiments, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 1-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1 or 2 independently selected R 4A It is substituted with a substituent.

[0179] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-10 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, C(O)R b4 , C(O)NR c4 R d4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C 1-6 Alkyl-, and C 3-6 Cycloalkyl-C 1-6 Each alkyl group consists of one or two independently selected R groups, which are optional. 4AIt is substituted with a substituent.

[0180] In some embodiments, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, C(O)R b4 , and S(O)2R b4 Selected from, R 4 C 2-6 Alkyl, phenyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl are each optionally selected from 1 or 2 independently selected R 4A It is substituted with a substituent.

[0181] Several embodiments, each R a4 , R b4 , R c4 , and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6 Selected from cycloalkyl and phenyl.

[0182] Several embodiments, each R a4 , R b4 , R c4 , and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-6 Selected from cycloalkyl groups.

[0183] Several embodiments, each R a4 and R b4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0184] Several embodiments, each R a4 and R b4 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0185] Several embodiments, each R b4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0186] Several embodiments, each R b4 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0187] Several embodiments, each R b4 H is H.

[0188] Several embodiments, each R b4 C 1-6 It is alkyl.

[0189] Several embodiments, each R c4 and R d4 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-6 Selected from cycloalkyl groups.

[0190] Several embodiments, each R c4 and R d4 H and C are independent of each other. 1-6 Alkyl and C 3-6 Selected from cycloalkyl groups.

[0191] Several embodiments, each R c4 and R d4 H and C are independent of each other. 3-6 Selected from cycloalkyl groups.

[0192] Several embodiments, each R c4 and R d4 This is independently selected from H and cyclopropyl.

[0193] In some embodiments, R c4 H is R d4 H and C are independent of each other. 3-6 Selected from cycloalkyl groups.

[0194] In some embodiments, R c4 H is R d4 This is independently selected from H and cyclopropyl.

[0195] In some embodiments, R c4 H is R d4 It is cyclopropyl.

[0196] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , C(O)NR c41 R d41 , and C(O)OR a41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B It is substituted with a substituent.

[0197] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b41 , C(O)NR c41 R d41 , and C(O)OR a41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B It is substituted with a substituent.

[0198] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , and C(O)NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B It is substituted with a substituent, and each R a41 H and C are independent of each other. 1-6 Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, each R b41 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0199] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C 1-6 Alkyl-, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , and C(O)R b41 Selected from, R 4A C 1-6Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C 1-6 Alkyl-, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B It is substituted with a substituent, and each R a41 H and C are independent of each other. 1-6 Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, each R b41 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0200] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , and C(O)NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B It is substituted with a substituent.

[0201] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, (4-10 member heterocycloalkyl)-C 1-6 Alkyl- and C(O)R b41 Selected from, R 4A C 1-6 Alkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R4B It is substituted with a substituent.

[0202] Several embodiments, each R a41 , R b41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl.

[0203] Several embodiments, each R a41 , R b41 , R c41 , and R d41 H and C are independent of each other. 1-6 Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl groups.

[0204] Several embodiments, each R a41 H and C are independent of each other. 1-6 Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl groups.

[0205] Several embodiments, each R b41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0206] Several embodiments, each R b41 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0207] Several embodiments, each R b41 H is H.

[0208] Several embodiments, each R b41 C 1-6 It is alkyl.

[0209] Several embodiments, each R c41 and R d41 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0210] Several embodiments, each R c41 H is H.

[0211] Several embodiments, each R c41 C 1-6 It is alkyl.

[0212] Several embodiments, each R d41 H is H.

[0213] Several embodiments, each R d41 C 1-6 It is alkyl.

[0214] In some embodiments, Each R 4A They are independent, Hello, C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , and C(O)NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B Substituting with substituents, Each R a41 , R b41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6Alkinyl, C 3-6 Selected from cycloalkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl.

[0215] In some embodiments, Each R 4A They are independent, Hello, C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , and C(O)NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B Substituting with substituents, Each R a41 and R b41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, Each R c41 and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl and C 3-6 Selected from cycloalkyl groups.

[0216] In some embodiments, Each R 4A They are independent, Hello, C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (4-6 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)Rb41 , and C(O)NR c41 R d41 Selected from, R 4A C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B Substituting with substituents, Each R a41 and R b41 H and C are independent of each other. 1-6 Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl groups, Each R c41 and R d41 H and C are independent of each other. 3-6 Selected from cycloalkyl groups.

[0217] Several embodiments, each R 4A They are independent, Hello, C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (4-6 member heterocycloalkyl)-C 1-6 Alkyl- and C(O)R b41 Selected from, R 4A C 1-6 Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and (4-6 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from one or two independently chosen R 4B It is substituted with a substituent, and each R b41 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0218] Several embodiments, each R 4Ais independently selected from fluoro, methyl, cyano, hydroxy, methoxy, N,N-dimethylaminocarbonyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, and pyridylmethyl, and methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinylmethyl, and pyridylmethyl are each, optionally, substituted with one or two R 4B substituents.

[0219] In some embodiments, each R 4A is independently selected from fluoro, methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, and pyridylmethyl, and methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinylmethyl, and pyridylmethyl are each, optionally, substituted with one or two R 4B substituents.

[0220] In some embodiments, each R 4B is independently selected from C 1-6 alkyl, C 1-6 alkylsulfonyl, di(C 1-6 alkyl)amino, and C 1-6 alkylcarbonyl, and di(C 1-6 alkyl)amino is optionally substituted with C 1-6 alkylsulfonyl.

[0221] In some embodiments, each R 4AThe following are independently selected from fluoro, methyl, cyano, hydroxy, methoxy, N,N-dimethylaminocarbonyl, ethyl, 2-methylpropyl, difluoroethyl, hydroxy, cyano, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl, and each of the following is optionally selected from C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0222] Several embodiments, each R 4A The following are independently selected from fluoro, methyl, ethyl, 2-methylpropyl, difluoroethyl, hydroxy, cyano, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl, and each of the following is optionally selected from C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4BSubstituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0223] Several embodiments, each R a42 , R b42 , R c42 , and R d42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0224] Several embodiments, each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0225] Several embodiments, each R 4B C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 Selected from alkylcarbonyl, di(C 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0226] Several embodiments, each R a42 , R b42 , R c42 , and R d42 H and C are independent of each other. 1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0227] Several embodiments, each R a42 , R b42 , R c42 , and R d42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0228] Several embodiments, each R a42 H and C are independent of each other.1-6 Alkyl, C 2-6 Alkenyl and C 2-6 Selected from Alkinyl.

[0229] Several embodiments, each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0230] Several embodiments, each R 4B C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 Selected from alkylcarbonyl, di(C 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, and each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0231] Several embodiments, each R 4A The following are independently selected from fluoro, methyl, ethyl, 2-methylpropyl, difluoroethyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl, and each of the following is optionally selected from C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, and each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0232] Several embodiments, each R 4A The following are independently selected from fluoro, methyl, ethyl, 2-methylpropyl, difluoroethyl, hydroxy, cyano, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl, and each of the following is optionally selected from C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, and each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0233] Several embodiments, each R 4A The following are independently selected from fluoro, methyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, and pyridylmethyl, where each of methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, and pyridylmethyl is optional. 1-6 Alkyl, C 1-6Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0234] Several embodiments, each R 4A The following are independently selected from fluoro, methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, and pyridylmethyl, and each of the following is optionally selected: C 1-6 Alkyl, C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0235] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally used in groups of 1 or 2 R4A It is substituted by a substituent.

[0236] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl are optionally used in 1 or 2 R 4A It is substituted by a substituent.

[0237] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4AMethyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each optionally used in 1 or 2 R 4B It is substituted by a substituent.

[0238] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl are optionally selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4A Methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each optionally used in 1 or 2 R 4B It is substituted by a substituent.

[0239] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4A Methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each optionally selected as C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, and each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0240] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl. 4Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl are optionally selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4A Methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each optionally selected as C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, and each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0241] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally used in groups of 1 or 2 R 4A It is substituted by a substituent.

[0242] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl are optionally used in 1 or 2 R 4A It is substituted by a substituent.

[0243] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyramidyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally selected from fluoro, methyl, piperidinyl, piperazinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, and pyridylmethyl, and one or two R 4A Substituting with substituents, R 4AMethyl, piperidinyl, piperadinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, and pyridylmethyl each optionally contain 1 or 2 R 4B It is substituted by a substituent.

[0244] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl are optionally selected from fluoro, methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4A Methyl, piperidinyl, piperadinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, and pyridylmethyl each optionally contain 1 or 2 R 4B It is substituted by a substituent.

[0245] In some embodiments, R 4 R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. 4Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyramidyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are optionally selected from fluoro, methyl, piperidinyl, piperazinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, and pyridylmethyl, and one or two R 4A Substituting with substituents, R 4A Methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, and pyridylmethyl are each optionally selected as C 1-6 Alkyl, C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0246] In some embodiments, R 4 R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl. 4 Phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, and pyridyl are optionally selected from fluoro, methyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, and pyridylmethyl, one or two R 4A Substituting with substituents, R 4AMethyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, and pyridylmethyl are each optionally selected as C 1-6 Alkyl, C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 One or two R selected independently from alkylcarbonyl 4B Substituting with substituents, di(C) 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl.

[0247] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, or 3 independently selected R 1A Substituting with substituents, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A Substituting with substituents, Each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 Alkyl and C 3-10 Cycloalkyl groups are optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B Substituting with substituents, Each R 2B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Selected from alkynyl, CN, and NO2, R 2B Each C 1-6 Alkyl groups are optionally substituted with cyano groups. R 3 H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 SO2R b31 , and NR c31 R d31 Selected from, R3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R a31 , R b31 , R c31 , and R d31 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Selected from alkynyl, each R a31 , R b31 , R c31 , and R d31 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl and C 2-6 Alkinyl is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkynyl, phenyl, 4-6 member heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 3BEach phenyl and 4-6 member heterocycloalkyl group can be optionally selected as S(O)2R b33 It has been replaced with, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4ASubstituting with substituents, Each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , C(O)NR c41 R d41 , and C(O)OR a41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B Substituting with substituents, Each R a41 , R b41 , R c41 , and R d41 H and C are independent of each other. 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-6Selected from cycloalkyl, phenyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, Each R 4B C 1-6 Alkyl, OR a42 , C 1-6 Alkyl sulfonyl, di(C 1-6 Alkyl)amino, and C 1-6 Selected from alkylcarbonyl, di(C 1-6 Alkyl)amino is optional, C 1-6 It is substituted with alkylsulfonyl, Each R a42 H and C are independent of each other. 1-6 Selected from alkyl groups.

[0248] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, or 3 independently selected R 1A Substituting with substituents, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A Substituting with substituents, Each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 3-10 Cycloalkyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 , NR c21 C(O)R b21 S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 The alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B Substituting with substituents, R 3 H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 SO2R b31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R 3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkynyl, 4-6 membered heterocycloalkyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4, and S(O)2NR c4 R d4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Substituting with substituents, Each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, OR a41 , C(O)R b41 , C(O)NR c41 R d41 , and C(O)OR a41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B It is substituted with a substituent.

[0249] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, or 3 independently selected R 1A Substituting with substituents, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A Substituting with substituents, Each R 2A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a21 , SR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , NR c21 R d21 S(O)R b21 , S(O)NR c21 R d21 S(O)2R b21 , and S(O)2NR c21 R d21 Selected from, R 2A C 1-6 The alkyl group can be optionally selected from 1, 2, 3, or 4 independently selected R groups. 2B Substituting with substituents, R 3 H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 3 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A Substituting with substituents, Each R 3A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , SR a31 , and NR c31 R d31 Selected from, R 3A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B Substituting with substituents, Each R3B They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, CN, NO2, OR a32 , SR a32 , C(O)R b32 , C(O)NR c32 R d32 , and C(O)OR a32 Selected from, R 4 Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a4 , SR a4 , C(O)R b4 , C(O)NR c4 R d4 , C(O)OR a4 , NR c4 R d4 S(O)R b4 , S(O)NR c4 R d4 S(O)2R b4 , and S(O)2NR c4 R d4 Selected from, R 4 C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4A Substituting with substituents, Each R 4A They are independent, Hello, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b41 , C(O)NR c41 R d41 , and C(O)OR a41 Selected from, R 4A C 1-6 Alkyl, C 2-6 Alkenil, C 2-6 Alkinyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and (4-10 member heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 4B It is substituted with a substituent.

[0250] In some embodiments, R 1 H and C 1-6 Selected from alkyl, R 1 C 1-6 Alkyl is optionally selected from 1, 2, or 3 independently selected R 1A Substituting with substituents, R 2 H, C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, (4-10 member heterocycloalkyl)-C 1-6 Selected from alkyl-, R 2 C 1-6 Alkyl, C 6-10 Ariel, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 member heteroaryl)-C 1-6 Alkyl-, and ...

Claims

1. Formula I: 【Chemistry 1】 [In the formula, R １ H and C １－６ Selected from alkyl groups, R １ C １－６ Alkyl groups may be substituted with OH groups. R ２ is H, C １－６ alkyl, C ６－１０ aryl, C ３－１０ cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ aryl-C １－６ alkyl-, C ３－１０ cycloalkyl-C １－６ alkyl-, (5- to 10-membered heteroaryl)-C １－６ alkyl-, and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl- selected from, and R ２ said C of[[ID=2三十三]] １－６ alkyl, C ６－１０ aryl, C ３－１０ cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ aryl-C １－６ alkyl-, C ３－１０ cycloalkyl-C １－６ alkyl-, (5- to 10-membered heteroaryl)-C １－６ alkyl-, and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl- may each be substituted with 1, 2, 3, or 4 independently selected R ２Ａ substituents, Each R ２Ａ It is independent, Haro, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－１０ Cycloalkyl, CN, NO ２ , OR ａ２１ , SR ａ２１ , C(O)R ｂ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ OC(O)R ｂ２１ , OC(O)NR ｃ２１ R ｄ２１ , NR ｃ２１ R ｄ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ S(O)R ｂ２１ S(O)NR ｃ２１ R ｄ２１ , S(O) ２ R ｂ２１ , and S(O) ２ NR ｃ２１ R ｄ２１ Selected from, R ２Ａ C １－６ The alkyl group consists of 1, 2, 3, or 4 independently selected R ２Ｂ They may be substituted with substituents, Each R ａ２１ , R ｃ２１ , and R ｄ２１ H and C are independent of each other. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl and C ２－６ Selected from Alkinil, R ａ２１ , R ｃ２１ , and R ｄ２１ C １－６ Alkyl, C ２－６ Alkenyl and C ２－６ Each alkynyl is selected from 1, 2, 3, or 4 independently selected R ２Ｂ May it be substituted with a substituent? Alternatively, any R ｃ２１ and R ｄ２１ These, together with the N atom to which they are bonded, form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group. Each R ｂ２１ H and C are independent of each other. １－６ Selected from alkyl, the C １－６ Each alkyl group consists of 1, 2, 3, or 4 independently selected R ２Ｂ They may be substituted with substituents, Each R ２Ｂ Independently, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkynyl, CN, and NO ２ Selected from, R ２Ｂ Each C １－６ Alkyl may be substituted with cyano. R ３ is selected from H, phenyl-C ２－６ alkynyl-, C ６－１０ aryl, C ３－１０ cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ aryl-C １－６ alkyl-, C ３－１０ cycloalkyl-C １－６ alkyl-, (5- to 10-membered heteroaryl)-C １－６ alkyl-, and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-; provided that the C of R ３ aryl, C ６－１０ cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ３－１０ aryl-C ６－１０ alkyl-, C １－６ cycloalkyl-C ３－１０ alkyl-, (5- to 10-membered heteroaryl)-C １－６ alkyl-, and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl- may each be substituted with 1, 2, 3, or 4 independently selected R １－６ substituents, and ３Ａ ​ Each R ３Ａ It is independent, Haro, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl-, (4-10 member heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ３１ , SR ａ３１ , S(O) ２ R ｂ３１ , and NR ｃ３１ R ｄ３１ Selected from, R ３Ａ C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl- and (4-10 member heterocycloalkyl)-C １－６ Each alkyl group consists of 1, 2, 3, or 4 independently selected R groups. ３Ｂ They may be substituted with substituents, Each R ａ３１ , R ｂ３１ , R ｃ３１ , and R ｄ３１ These are H and C, independently. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl and C ２－６ Selected from Alkinyl, each R ａ３１ , R ｂ３１ , R ｃ３１ , and R ｄ３１ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl and C ２－６ Alkinyl is one, two, three, or four independently selected R ３Ｂ They may be substituted with substituents, Each R ３Ｂ It is independent, Haro, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkynyl, phenyl, 4-6 member heterocycloalkyl, CN, NO ２ , OR ａ３２ , SR ａ３２ , C(O)R ｂ３２ , C(O)NR ｃ３２ R ｄ３２ , and C(O)OR ａ３２ Selected from, R ３Ｂ Each phenyl and 4-6 member heterocycloalkyl group is S(O) ２ R ｂ３３ It may also be replaced with Each R ａ３２ , R ｃ３２ , and R ｄ３２ These are H and C, independently. １－６ Selected from alkyl groups and 4-6 membered heterocycloalkyl groups, Each R ｂ３２ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ｂ３３ Independently, C １－６ Selected from alkyl groups, R ４ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl-, (4-10 member heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , and S(O) ２ R ｂ４ Selected from, R ４ C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl- and (4-10 member heterocycloalkyl)-C １－６ Each alkyl group consists of 1, 2, 3, or 4 independently selected R groups. ４Ａ They may be substituted with substituents, Each R ｂ４ , R ｃ４ , and R ｄ４ These are H and C, independently. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl and C ３－６ Selected from cycloalkyl groups, Each R ４Ａ It is independent, Haro, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl-, (4-10 member heterocycloalkyl)-C １－６ Alkyl-, CN, OR ａ４１ , C(O)R ｂ４１ , C(O)NR ｃ４１ R ｄ４１ , and C(O)OR ａ４１ Selected from, R ４Ａ C １－６ Alkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl- and (4-10 member heterocycloalkyl)-C １－６ Each alkyl group consists of 1, 2, 3, or 4 independently selected R groups. ４Ｂ They may be substituted with substituents, Each R ａ４１ , R ｂ４１ , R ｃ４１ , and R ｄ４１ These are H and C, independently. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl, C ３－６ Selected from cycloalkyl, phenyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, Each R ４Ｂ Independently, C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ Selected from alkylcarbonyl, the di(C １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, Each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups] A compound of or a pharmaceutically acceptable salt thereof.

2. R １ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, selected from H, methyl, ethyl, and hydroxyethyl.

3. R ２ However, H, C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and (5-10 membered heteroaryl)-C １－６ Selected from alkyl-, R ２ C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and (5-10 membered heteroaryl)-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ２Ａ The compound according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, which may be substituted with substituents.

4. R ２ However, H, C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C １－６ Selected from alkyl-, R ２ C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, and (5-6 member heteroaryl)-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ２Ａ The compound according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, which may be substituted with substituents.

5. Each R ２Ａ C １－６ Alkyl, C ３－１０ Cycloalkyl, OR ａ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ , and S(O)R ｂ２１ Selected from, R ２Ａ C １－６ Alkyl and C ３－１０ Each of the cycloalkyl groups R is independently selected from one or two groups. ２Ｂ A compound according to any one of claims 1 to 4, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

6. Each R ａ２１ , R ｃ２１ , and R ｄ２１ H and C are independent of each other. １－６ Selected from alkyl groups, Alternatively, any R ｃ２１ and R ｄ２１ However, together with the N atom to which they are bonded, they form a 4-6 member heterocycloalkyl group. Each R ｂ２１ H and C are independent of each other. １－６ Selected from alkyl, the C １－６ Each alkyl group is independently selected as R, with 1, 2, 3, or 4 alkyl groups. ２Ｂ They may be substituted with substituents. A compound according to any one of claims 1 to 5, or a pharmaceutically acceptable salt thereof.

7. Each R ２Ａ R is independently selected from methyl, cyclobutyl, methoxy, ethylamide, methoxyethylamide, piperidinylcarbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl. ２Ａ Each cyclobutyl is C １－６ One R is alkyl ２Ｂ R may be substituted by substituents, ２Ｂ C １－６ The compound according to any one of claims 1 to 4, or a pharmaceutically acceptable salt thereof, wherein the alkyl group may be substituted with a cyano group.

8. R ２ The following are selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranil, piperidinyl, azaspiro[3.5]nonanyl, pyridyl, benzofuranil, and pyrazolylmethyl, and the aforementioned cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2 1) heptanyl, phenyl, tetrahydropyranil, piperidinyl, azaspiro[3.5]nonanil, pyridyl, benzofuranil, and pyrazolylmethyl are each independently selected from methyl, cyanomethylcyclobutyl, methoxy, ethylamide, methoxyethylamide, piperidinylcarbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl. ２Ａ The compound according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, which may be substituted with a group.

9. R ３ However, H, phenyl-C ２－６ Alkinyl-, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl- and (4-10 member heterocycloalkyl)-C １－６ Selected from alkyl-, R ３ C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5-10 member heteroaryl)-C １－６ Alkyl- and (4-10 member heterocycloalkyl)-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ３Ａ A compound according to any one of claims 1 to 8, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

10. R ３ However, H, phenyl-C ２－６ Alkinyl-, C ６－１０ Ariel, C ３－１０ Selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, R ３ C ６－１０ Ariel, C ３－１０ R is independently selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl groups, each comprising 1, 2, 3, or 4 members. ３Ａ A compound according to any one of claims 1 to 8, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

11. Each R ３Ａ C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, CN, OR ａ３１ , C(O)R ｂ３１ , and SO ２ R ｂ３１ Selected from, R ３Ａ C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, and C ６－１０ Aryl-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ３Ｂ A compound according to any one of claims 1 to 10, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

12. Each R ３Ａ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C １－６ Alkyl-, CN, C(O)R ｂ３１ SO ２ R ｂ３１ , and OR ａ３１ Selected from, R ３Ａ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C １－６ Each alkyl group is independently selected from one or two R groups. ３Ｂ They may be substituted with substituents, and each R ａ３１ and R ｂ３１ H and C are independent of each other. １－６ A compound according to any one of claims 1 to 10, selected from alkyl groups, or a pharmaceutically acceptable salt thereof.

13. Each R ３Ｂ These independently consist of phenyl, 4-6 member heterocycloalkyl, CN, OR ａ３２ , C(O)R ｂ３２ , and C(O)OR ａ３２ Selected from, R ３Ｂ Each phenyl is S(O) ２ R ｂ３３ It may also be replaced with Each R ａ３２ H and C became independent. １－６ Selected from alkyl groups and 4-6 membered heterocycloalkyl groups, Each R ｂ３２ H and C are independent of each other. １－６ Selected from alkyl groups, A compound according to any one of claims 1 to 12, or a pharmaceutically acceptable salt thereof.

14. Each R ３Ｂ A compound according to any one of claims 1 to 12, wherein the compound is independently selected from phenyl, morpholinyl, CN, tetrahydropyranyloxy, methylcarbonyl, and C(O)OH, or a pharmaceutically acceptable salt thereof.

15. R ３ The following are selected from H, phenylethynyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanyl, thiazolyl, indazolyl, piperidinyl, and pyridyl, and the aforementioned phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl Each of the following R compounds is independently selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperidinyl, and methylsulfonyl: R, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, piperidinyl, and pyridyl, respectively, and one or two R compounds are independently selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, methylcarbonyl, and methylsulfonyl. ３Ａ The compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof, which may be substituted with a group, wherein the methyl group of the methylcarbonyl is substituted with methylsulfonylphenyl.

16. R ４ However, C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , and S(O) ２ R ｂ４ Selected from, R ４ C １－６ Alkyl, C ６－１０ Ariel, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ４Ａ A compound according to any one of claims 1 to 15, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

17. R ４ However, C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , and S(O) ２ R ｂ４ Selected from, R ４ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl- and C ３－６ Cycloalkyl-C １－６ Each alkyl group is independently selected from one or two R groups. ４Ａ A compound according to any one of claims 1 to 15, which may be substituted with substituents, or a pharmaceutically acceptable salt thereof.

18. Each R ４Ａ They became independent, Hello, C １－６ Alkyl, C １－６ Haloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl-, (4-6 member heterocycloalkyl)-C １－６ Alkyl-, CN, OR ａ４１ , C(O)R ｂ４１ , and C(O)NR ｃ４１ R ｄ４１ Selected from, R ４Ａ C １－６ Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl- and (4-6 member heterocycloalkyl)-C １－６ Each alkyl group is independently selected from one or two R groups. ４Ｂ They may be substituted with substituents, and each R ａ４１ H and C became independent. １－６ Selected from alkyl, 5-6 member heteroaryl, and 4-6 member heterocycloalkyl, each R ｂ４１ H and C are independent of each other. １－６ A compound according to any one of claims 1 to 17, selected from alkyl groups, or a pharmaceutically acceptable salt thereof.

19. Each R ４Ａ The following are independently selected from fluoro, methyl, cyano, hydroxy, methoxy, N,N-dimethylaminocarbonyl, ethyl, 2-methylpropyl, difluoroethyl, hydroxy, cyano, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl, and the methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ One or two R selected independently from alkylcarbonyl ４Ｂ The substituents may be substituted, and the di(C) １－６ Alkyl)amino is C １－６ A compound according to any one of claims 1 to 17, or a pharmaceutically acceptable salt thereof, which may be substituted with an alkylsulfonyl.

20. R ４ However, R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. ４ The phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are independently selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, one or two R ４Ａ They may be substituted with substituents, R ４Ａ The aforementioned methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl are each C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ One or two R selected independently from alkylcarbonyl ４Ｂ The substituents may be substituted, and the di(C) １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, and each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups, A compound according to any one of claims 1 to 15, or a pharmaceutically acceptable salt thereof.

21. R １ However, H and C １－６ Selected from alkyl groups, R １ C １－６ The alkyl group may be substituted with an OH group. R ２ However, H, C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 membered heteroaryl, 4-6 membered heterocycloalkyl, and (5-6 membered heteroaryl)-C １－６ Selected from alkyl-, R ２ C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 membered heteroaryl, 4-6 membered heterocycloalkyl, and (5-6 membered heteroaryl)-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ２Ａ They may be substituted with substituents, Each R ２Ａ C １－６ Alkyl, C ３－１０ Cycloalkyl, OR ａ２１ , C(O)NR ｃ２１ R ｄ２１ , and NR ｃ２１ C(O)R ｂ２１ Selected from, Each R ａ２１ , R ｃ２１ , and R ｄ２１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl and C ２－６ Selected from Alkinil, R ａ２１ , R ｃ２１ , and R ｄ２１ C １－６ Alkyl, C ２－６ Alkenyl and C ２－６ Each of the alkynyls is independently selected as R, with 1, 2, 3, or 4 selected. ２Ｂ May it be substituted with a substituent? Alternatively, any R ｃ２１ and R ｄ２１ However, together with the N atom to which they are bonded, they form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group. Each R ｂ２１ H and C are independent of each other. １－６ Selected from alkyl, the C １－６ Each alkyl group is independently selected as R, with 1, 2, 3, or 4 alkyl groups. ２Ｂ They may be substituted with substituents, R ３ However, H, C ６－１０ Ariel, C ３－１０ Selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, R ３ C ６－１０ Ariel, C ３－１０ R is independently selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl groups, each comprising 1, 2, 3, or 4 members. ３Ａ They may be substituted with substituents, Each R ３Ａ C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C １－６ Alkyl-, CN, OR ａ３１ , and SO ２ R ｂ３１ Selected from, R ３Ａ C １－６ Alkyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C １－６ Each alkyl group is independently selected from one or two R groups. ３Ｂ They may be substituted with substituents, Each R ａ３１ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ｂ３１ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ３Ｂ These independently form 4-6 member heterocycloalkyl, CN, OR ａ３２ , C(O)R ｂ３２ , and C(O)OR ａ３２ Selected from, Each R ａ３２ H and C became independent. １－６ Selected from alkyl groups and 4-6 membered heterocycloalkyl groups, Each R ｂ３２ H and C are independent of each other. １－６ Selected from alkyl groups, R ４ However, C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C(O)R ｂ４ , and S(O) ２ R ｂ４ Selected from, R ４ C １－６ Alkyl, phenyl, C ３－６ One or two independently selected R members each consist of a cycloalkyl group, a 5-10 member heteroaryl group, and a 4-10 member heterocycloalkyl group. ４Ａ They may be substituted with substituents, Each R ４Ａ They became independent, Hello, C １－６ Alkyl, C １－６ Haloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl-, (4-6 member heterocycloalkyl)-C １－６ Alkyl-, CN, OR ａ４１ , and C(O)R ｂ４１ Selected from, R ４Ａ C １－６ Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl- and (4-6 member heterocycloalkyl)-C １－６ Each alkyl group is independently selected from one or two R groups. ４Ｂ They may be substituted with substituents, Each R ａ４１ H and C became independent. １－６ Selected from alkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl groups, Each R ｂ４１ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ４Ｂ C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ Selected from alkylcarbonyl, the di(C １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, Each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

22. R １ However, H and C １－６ Selected from alkyl groups, R １ C １－６ The alkyl group may be substituted with an OH group. R ２ However, H, C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, (5-6 member heteroaryl)-C １－６ Alkyl- and (6-10 member heterocycloalkyl)-C １－６ Selected from alkyl-, R ２ C １－６ Alkyl, phenyl, C ３－１０ Cycloalkyl, 5-10 member heteroaryl, 6-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, (5-6 member heteroaryl)-C １－６ Alkyl- and (6-10 member heterocycloalkyl)-C １－６ R is selected independently, with each alkyl group having 1, 2, 3, or 4 alkyl groups. ２Ａ They may be substituted with substituents, Each R ２Ａ C １－６ Alkyl, C ３－１０ Cycloalkyl, OR ａ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)OR ａ２１ , NR ｃ２１ C(O)R ｂ２１ , NR ｃ２１ C(O)OR ａ２１ , and S(O)R ｂ２１ Selected from, R ２Ａ C １－６ Alkyl and C ３－１０ Each of the cycloalkyl groups R is independently selected from one or two groups. ２Ｂ They may be substituted with substituents, Each R ａ２１ , R ｃ２１ , and R ｄ２１ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl and C ２－６ Selected from Alkinil, R ａ２１ , R ｃ２１ , and R ｄ２１ C １－６ Alkyl, C ２－６ Alkenyl and C ２－６ Each of the alkynyls is independently selected as R, with 1, 2, 3, or 4 selected. ２Ｂ May it be substituted with a substituent? Alternatively, any R ｃ２１ and R ｄ２１ However, together with the N atom to which they are bonded, they form a 5-6 member heteroaryl or 4-6 member heterocycloalkyl group. Each R ｂ２１ H and C are independent of each other. １－６ Selected from alkyl, the C １－６ Each alkyl group is independently selected as R, with 1, 2, 3, or 4 alkyl groups. ２Ｂ They may be substituted with substituents, Each R ２Ｂ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkynyl, CN, and NO ２ Selected from, R ２Ｂ Each C １－６ The alkyl group may be substituted with a cyano compound. R ３ However, H, phenyl-C ２－６ Alkinyl-, C ６－１０ Ariel, C ３－１０ Selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, R ３ C ６－１０ Ariel, C ３－１０ R is independently selected from cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl groups, each comprising 1, 2, 3, or 4 members. ３Ａ They may be substituted with substituents, Each R ３Ａ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, phenyl-C １－６ Alkyl-, CN, C(O)R ｂ３１ SO ２ R ｂ３１ , and OR ａ３１ Selected from, R ３Ａ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, and phenyl-C １－６ Each alkyl group is independently selected from one or two R groups. ３Ｂ They may be substituted with substituents, Each R ａ３１ and R ｂ３１ H and C are independent of each other. １－６ Selected from alkyl groups, each R ａ３１ and R ｂ３１ C １－６ Alkyl is one or two independently selected R ３Ｂ They may be substituted with substituents, Each R ３Ｂ These independently consist of phenyl, 4-6 member heterocycloalkyl, CN, OR ａ３２ , C(O)R ｂ３２ , and C(O)OR ａ３２ Selected from, R ３Ｂ Each phenyl is S(O) ２ R ｂ３３ It may also be replaced with Each R ａ３２ H and C became independent. １－６ Selected from alkyl groups and 4-6 membered heterocycloalkyl groups, Each R ｂ３２ H and C are independent of each other. １－６ Selected from alkyl groups, R ４ However, C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, C(O)R ｂ４ , C(O)NR ｃ４ R ｄ４ , and S(O) ２ R ｂ４ Selected from, R ４ C １－６ Alkyl, phenyl, C ３－６ Cycloalkyl, 5-10 member heteroaryl, 4-10 member heterocycloalkyl, phenyl-C １－６ Alkyl- and C ３－６ Cycloalkyl-C １－６ Each alkyl group is independently selected from one or two R groups. ４Ａ They may be substituted with substituents, Each R ｂ４ , R ｃ４ , and R ｄ４ H and C became independent. １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenil, C ２－６ Alkinyl and C ３－６ Selected from cycloalkyl groups, Each R ４Ａ They became independent, Hello, C １－６ Alkyl, C １－６ Haloalkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl-, (4-6 member heterocycloalkyl)-C １－６ Alkyl-, CN, OR ａ４１ , C(O)R ｂ４１ , and C(O)NR ｃ４１ R ｄ４１ Selected from, R ４Ａ C １－６ Alkyl, 5-6 member heteroaryl, 4-6 member heterocycloalkyl, (5-6 member heteroaryl)-C １－６ Alkyl- and (4-6 member heterocycloalkyl)-C １－６ Each alkyl group is independently selected from one or two R groups. ４Ｂ They may be substituted with substituents, Each R ａ４１ H and C became independent. １－６ Selected from alkyl, 5-6 membered heteroaryl, and 4-6 membered heterocycloalkyl groups, Each R ｂ４１ H and C are independent of each other. １－６ Selected from alkyl groups, Each R ｃ４１ and R ｄ４１ H and C are independent of each other. ３－６ Selected from cycloalkyl groups, Each R ４Ｂ C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ Selected from alkylcarbonyl, the di(C １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, Each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

23. R １ However, H and C １－６ Selected from alkyl groups, R １ C １－６ The alkyl group may be substituted with an OH group. R ２ The R is selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranil, piperidinil, azaspiro[3.5]nonanyl, pyridyl, benzofuranil, and pyrazolylmethyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, azabicyclo[3.2.1]octanyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranil, piperidinil, azaspiro[3.5]nonanyl, pyridyl, benzofuranil, and pyrazolylmethyl has one or two R ２Ａ It may also be substituted with the base, Each R ２Ａ R is independently selected from methyl, cyclobutyl, methoxy, ethylamide, methoxyethylamide, piperidinylcarbonyl, cyanomethyl, methoxycarbonyl, methoxycarbonylamino, ethoxycarbonylamino, methylaminocarbonyl, and methylsulfonyl. ２Ａ Each cyclobutyl is C １－６ One R is alkyl ２Ｂ R may be substituted by substituents, ２Ｂ C １－６ The alkyl group may be substituted with a cyano compound. R ３ The following are selected from H, phenylethynyl, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3.2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, piperidinyl, and pyridyl. Furthermore, each of the following compounds contains one or two R compounds: phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, piperidinyl, and pyridyl. ３Ａ It may be substituted by the group, Each R ３Ａ The following are independently selected from methyl, trideuterated methyl, phenyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, methylcarbonyl, and methylsulfonyl, wherein the methyl group of the methylcarbonyl is substituted with methylsulfonylphenyl. R ４ However, R is selected from ethyl, hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, cyclopropylaminocarbonyl, and methylsulfonyl. ４ The aforementioned phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, pyridyl, pyrazolo[1,5-a]pyrimidinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, cyclopropylmethyl, phenylmethyl, and cyclopropylaminocarbonyl are 1 or 2 R ４Ａ They may be substituted with substituents, Each R ４Ａ R is independently selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperadinyl, hydroxy, cyano, methoxy, N,N-dimethylaminocarbonyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, ４Ａ The aforementioned methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl each contain 1 or 2 R ４Ｂ They may be substituted with substituents, Each R ４Ｂ C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ Selected from alkylcarbonyl, the di(C １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, Each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

24. R １ However, H and C １－６ Selected from alkyl groups, R １ C １－６ The alkyl group may be substituted with an OH group. R ２ The R is selected from H, methyl, isopropyl, isobutyl, tert-butyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptanyl, phenyl, tetrahydropyranyl, pyridyl, benzofuranyl, and pyrazolylmethyl contains one or two R ２Ａ It may also be substituted with the base, Each R ２Ａ These are independently selected from methyl, methoxy, ethylamide, methoxyethylamide, and piperidinyl carbonyl. R ３ However, it is selected from H, phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3,2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazoyl, indazolyl, and pyridyl, and Phenyl, cyclohexenyl, pyrazolyl, cyclopropyl, dihydropyranyl, azabicyclo[4.1.0]heptanyl, dihydroindenyl, imidazopyridinyl, pyrrolo[1,2-a]pyradinyl, tetrahydrothieno[3,2-c]pyridinyl, thieno[3.2-c]pyridinyl, isoquinolinyl, benzothiazolyl, chromanil, thiazolyl, indazolyl, and pyridyl each contain one or two R ３Ａ It may be substituted by the group, Each R ３Ａ These are independently selected from methyl, cyano, hydroxy, methoxy, cyclopropyl, cyanocyclopropyl, morpholinyl, morpholinylcyclopropyl, piperazinyl, methylcarbonylpiperazinyl, tetrahydropyranyloxymethyl, benzyl, carboxybenzyl, and methylsulfonyl. R ４ However, R is selected from hydroxyethyl, isopropylcarbonyl, phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl. ４ The aforementioned phenyl, cyclopropyl, piperidinyl, dihydropyranyl, pyrazolyl, cyclohexenyl, and pyridyl are 1 or 2 R ４Ａ They may be substituted with substituents, Each R ４Ａ R is independently selected from CN, fluoro, methyl, ethyl, difluoroethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, isopropylcarbonyl, piperidinylmethyl, pyridyloxy, tetrahydropyranyloxy, isopropoxy, methoxy, and pyridylmethyl, ４Ａ The aforementioned methyl, ethyl, 2-methylpropyl, piperidinyl, piperazinyl, tetrahydrothiophene 1,1-dioxide, piperidinyl methyl, pyridyloxy, tetrahydropyranoxy, isopropoxy, methoxy, and pyridylmethyl each contain 1 or 2 R ４Ｂ They may be substituted with substituents, Each R ４Ｂ C １－６ Alkyl, OR ａ４２ , C １－６ Alkyl sulfonyl, di(C) １－６ Alkyl)amino, and C １－６ Selected from alkylcarbonyl, the di(C １－６ Alkyl)amino is C １－６ It may also be substituted with alkylsulfonyl, Each R ａ４２ H and C are independent of each other. １－６ Selected from alkyl groups, The compound according to claim 1, or a pharmaceutically acceptable salt thereof.

25. The compound of formula I is, formula II: 【Chemistry 2】 A compound of the compound described in claim 1 or a pharmaceutically acceptable salt thereof.

26. The compound of formula I is, formula IIa: 【Transformation 3】 [In the formula, n is 0, 1, 2, 3, or 4] A compound of the compound described in claim 1 or a pharmaceutically acceptable salt thereof.

27. The compound of formula I is, formula III: 【Chemistry 4】 A compound of the compound described in claim 1 or a pharmaceutically acceptable salt thereof.

28. The compound of formula I is, formula IV: 【Transformation 5】 [In the formula, n is 0, 1, or 2] A compound of the compound described in claim 1 or a pharmaceutically acceptable salt thereof.

29. 3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(benzofuran-5-yl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-(2-hydroxyethyl)-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(1,1-dioxidetetrahydrothiophen-3-yl)-1H-pyrazole-4-yl)-3-methyl-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-methyl-7-(4-((methyl(3-(methylsulfonylpropyl)propyl)amino)methyl)phenyl)-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(3-fluoro-4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3-methyl-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(4-(4-ethylpiperazine-1-yl)phenyl)-3-methyl-1-(pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclohexyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(tert-butyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclohexyl-3-methyl-7-(1-((methylsulfonyl)methyl)-1H-pyrazole-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-ethyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-1-(tetrahydro-2H-pyran-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(4-(4-ethylpiperazine-1-yl)phenyl)-3-methyl-1-((1-methyl-1H-pyrazole-4-yl)methyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(4-(4-ethylpiperazine-1-yl)phenyl)-3-methyl-1-(2-oxo-2-(piperidine-1-yl)ethyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Isopropyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclohexyl-8-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Isobutyl-8-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclobutyl-8-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-1-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(4-methoxyphenyl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(tert-butyl)-8-(4-methoxycyclohexa-1-en-1-yl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 4-(1-isopropyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile, 1-(4-(1-isopropyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, 4-((4-(1-isopropyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)-1H-pyrazole-1-yl)methyl)benzoic acid, 1-Cyclopentyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-7-(1-((methylsulfonyl)methyl)-1H-pyrazole-4-yl)-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(4-(1-cyclopentyl-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, 1-(4-(1-cyclopentyl-3-methyl-7-(1-((methylsulfonyl)methyl)-1H-pyrazole-4-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, 1-Cyclopentyl-8-(4-methoxycyclohexa-1-en-1-yl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-8-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-Cyclopropyl-1,3-dimethyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(6-methoxypyridine-3-yl)-1,3-dimethyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 4-(1-isopropyl-3-methyl-2-oxo-7-(1-(pyridine-4-ylmethyl)-1H-pyrazole-4-yl)-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile, 4-(7-(4-(4-acetylpiperazine-1-yl)phenyl)-1-isopropyl-3-methyl-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile, 4-(7-(3,6-dihydro-2H-pyran-4-yl)-1-isopropyl-3-methyl-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile, 4-(7-(3,6-dihydro-2H-pyran-4-yl)-1-isopropyl-3-methyl-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile, 1,3-dimethyl-8-phenyl-7-(pyridine-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1,3-dimethyl-8-phenyl-7-(piperidine-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(2-hydroxyethyl)-1,3-dimethyl-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-Isobutyryl-1,3-dimethyl-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Isopropyl-3-methyl-7-(1-((methylsulfonyl)methyl)-1H-pyrazole-4-yl)-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(bicyclo[2.2.1]heptan-2-yl)-3-methyl-7-(1-((methylsulfonyl)methyl)-1H-pyrazole-4-yl)-8-phenyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, and 3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-8-phenyl-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one A compound selected from, or a pharmaceutically acceptable salt thereof.

30. 1-Cyclopentyl-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-(4-(3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, 1-(4-(7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-3-methyl-8-(4-(1-morpholinocyclopropyl)phenyl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-(pyridine-4-ylmethyl)-1H-pyrazole-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(1-(2-methoxyethyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(1-(2,2-difluoroethyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(1-(2,2-difluoroethyl)-1H-pyrazole-4-yl)-3-methyl-8-(thieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, (S)-3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-8-phenyl-1-(tetrahydro-2H-pyran-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-8-(4-methoxyphenyl)-3-methyl-7-(1-(pyridine-4-ylmethyl)-1H-pyrazole-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(pyridine-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(pyridine-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Isopropyl-7-(6-methoxypyridine-3-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(6-methoxypyridine-3-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(6-methoxypyridine-3-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(6-isopropoxypyridine-3-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(6-((tetrahydro-2H-pyran-4-yl)oxy)pyridine-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(6-(pyridine-3-yloxy)pyridine-3-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-cyclopropyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(cyclohexa-1-en-1-yl)-1-cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-(2-hydroxyethyl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-7-cyclopropyl-3-methyl-8-(thieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 2-(1-cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-yl)cyclopropane-1-carbonitrile, N-(4-(7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)-2-methoxyacetamide, N-(4-(7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetamide, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(thieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(2-morpholinothiazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-8-(isoquinoline-6-yl)-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(benzo[d]thiazole-6-yl)-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(chroman-6-yl)-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(6-(piperazine-1-yl)thieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(6-(4-acetylpiperazine-1-yl)thieno[3,2-c]pyridine-2-yl)-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(5-(methylsulfonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(3-methylpyrrolo[1,2-a]pyrazine-7-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-8-(imidazo[1,5-a]pyridine-7-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 8-(1-hydroxy-2,3-dihydro-1H-inden-5-yl)-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-8-(4-(((tetrahydro-2H-pyran-4-yl)oxy)methyl)phenyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, and 8-(3-azabicyclo[4.1.0]heptan-6-yl)-7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-1-isopropyl-3-methyl-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one A compound selected from, or a pharmaceutically acceptable salt thereof.

31. 4-(1-cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-yl)-N,N-dimethylbenzamide, 3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(pyrazolo[1,5-a]pyrimidine-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 7-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, Methyl(1S)-3-(3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate, (1S)-3-(7-(4-methoxyphenyl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)-N-methyl-8-azabicyclo[3.2.1]octane-8-carboxamide, 7-(cyclopropyl(hydroxy)methyl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 4-((1-isopropyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-yl)methyl)benzonitrile, 1-Cyclopentyl-7-ethyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Cyclopentyl-N-cyclopropyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, 1-Cyclopentyl-3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(methylsulfonyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 1-Isopropyl-3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-8-(phenylethynyl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 2-((1S,3S)-3-(3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclobutyl)acetonitrile, 2-((1S,4S)-4-(3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetonitrile, 2-((1S,4S)-4-(7-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetonitrile, Methyl((1S,3S)-3-(3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclobutyl)carbamate, Ethyl ((1S,3S)-3-(8-(4-cyanophenyl)-3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclobutyl)carbamate, Ethyl ((1S,3S)-3-(8-(4-methoxyphenyl)-3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclobutyl)carbamate, 1-Isopropyl-3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-8-(1-(2-(4-(methylsulfonyl)phenyl)acetyl)piperidine-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 2-((1S,4S)-4-(7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetonitrile, 7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-(methyl-d3)-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 3-methyl-8-(1-(methyl-d3)-1H-indazole-5-yl)-7-(pyrazolo[1,5-a]pyrimidine-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, 2-(1-(4-(3-methyl-8-(1-methyl-1H-indazole-5-yl)-7-(1-methyl-1H-pyrazole-4-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)piperidine-1-yl)cyclobutyl)acetonitrile, and 4-(3-methyl-7-(1-methyl-1H-pyrazole-4-yl)-1-(2-(methylsulfonyl)-2-azaspiro[3.5]nonanane-7-yl)-2-oxo-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)benzonitrile A compound selected from, or a pharmaceutically acceptable salt thereof.

32. The compound 7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one, or a pharmaceutically acceptable salt thereof.

33. The compound is 7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-1-(tetrahydro-2H-pyran-4-yl)-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-2(1H)-one.

34. Compounds that are 2-((1S,4S)-4-(7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetonitrile, or pharmaceutically acceptable salts thereof.

35. A compound that is 2-((1S,4S)-4-(7-(3-methoxy-1-methyl-1H-pyrazole-4-yl)-3-methyl-8-(1-methyl-1H-indazole-5-yl)-2-oxo-3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(2H)-yl)cyclohexyl)acetonitrile.

36. A compound that is 1-(4-(3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitrile, or a pharmaceutically acceptable salt thereof.

37. The compound is 1-(4-(3-methyl-7-(4-((4-(methylsulfonyl)piperidine-1-yl)methyl)phenyl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)-1,2,3,6-tetrahydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-8-yl)phenyl)cyclopropane-1-carbonitride.

38. The compound is deuterated, the compound according to any one of claims 1 to 32, 34, and 36 or a pharmaceutically acceptable salt thereof, or the compound according to any one of claims 33, 35, and 37.

39. A pharmaceutical composition comprising a compound according to any one of claims 1 to 32, 34, 36, and 38 or a pharmaceutically acceptable salt thereof, or a compound according to any one of claims 33, 35, and 37, and a pharmaceutically acceptable carrier.

40. A pharmaceutical agent for inhibiting the activity of the V617F variant of JAK2 kinase, comprising any one of claims 1 to 32, 34, 36, and 38 or a pharmaceutically acceptable salt thereof, or any one of claims 33, 35, and 37.

41. A pharmaceutical for treating cancer in a patient who requires treatment for cancer, comprising any one of the compounds described in claims 1 to 32, 34, 36, and 38 or a pharmaceutically acceptable salt thereof, or any one of the compounds described in claims 33, 35, and 37.

42. The pharmaceutical product according to claim 41, wherein the cancer is selected from bladder cancer, breast cancer, cervical cancer, colorectal cancer, small intestine cancer, colon cancer, rectal cancer, anal cancer, endometrial cancer, stomach cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, ovarian cancer, prostate cancer, testicular cancer, uterine cancer, vulvar cancer, esophageal cancer, gallbladder cancer, pancreatic cancer, stomach cancer, thyroid cancer, parathyroid cancer, neuroendocrine cancer, skin cancer, and brain cancer.

43. The pharmaceutical product according to claim 41, wherein the cancer is a blood cancer.

44. The pharmaceutical product according to claim 41, wherein the cancer is selected from leukemia, lymphoma, multiple myeloma, chronic lymphocytic lymphoma, adult T-cell leukemia, acute myeloid leukemia, B-cell lymphoma, cutaneous T-cell lymphoma, acute myeloid leukemia, Hodgkin lymphoma or non-Hodgkin lymphoma, myeloproliferative neoplasm, myelodysplastic syndrome, chronic eosinophilic leukemia, Waldenström macroglobulinemia, hairy cell lymphoma, chronic myeloid lymphoma, acute lymphoblastic lymphoma, AIDS-associated lymphoma, and Burkitt lymphoma.

45. A pharmaceutical for treating a myeloproliferative disorder in a patient requiring treatment, comprising a compound according to any one of claims 1 to 32, 34, 36, and 38 or a pharmaceutically acceptable salt thereof, or a compound according to any one of claims 33, 35, and 37.

46. The pharmacopoeia according to claim 45, wherein the myeloproliferative disorder is selected from polycythemia vera, essential thrombocythemia, myelofibrosis with myelogenesis, primary myelofibrosis, post-essential thrombocythemia myelofibrosis, post-polycythemia myelofibrosis, chronic myeloid leukemia, chronic myelomonocytic leukemia, eosinophilic syndrome, and systemic mast cell disease.

47. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is polycythemia vera.

48. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is essential thrombocythemia.

49. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is myelofibrosis with myelometaplastic metaplasia.

50. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is primary myelofibrosis.

51. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is post-essential thrombocythemia myelofibrosis.

52. The pharmaceutical product according to claim 45 or 46, wherein the myeloproliferative disorder is post-polycythemia vera myelofibrosis.

53. A pharmaceutical agent for treating myelodysplastic syndrome in a patient requiring treatment for myelodysplastic syndrome, comprising any one of the compounds described in claims 1 to 32, 34, 36, and 38 or a pharmaceutically acceptable salt thereof, or any one of the compounds described in claims 33, 35, and 37.

Images