Skincare serum containing sodium hyaluronate and polyacrylamide polymer

Abstract

A physically stable skin care serum emulsion composition having a continuous phase and a dispersed phase. The continuous phase can include about 0.5% to about 1.5% sodium hyaluronate having a weight average molecular weight of about 500,000 to about 1,000,000 Da according to the European Pharmacopoeia. The continuous phase can also include a thickening agent, including polyacrylamide polymers and copolymers. The dispersed phase can include a silicone. The composition can have an average viscosity of about 4,000 cP to about 25,000 cP and can be stored and dispensed via a dropper package.

Description

[Technical Field]

[0001] The present invention generally relates to skincare compositions containing hyaluronic acid and a thickening agent, particularly those with a weight-average molecular weight of about 200,000 Da to about 1,500,000 Da, a thickening agent of 0.5% or more, and about 3,000 cP (2 Pa). * s)~Approx. 25,000cP(25Pa * The subject is a physically stable skincare emulsion composition containing more than 0.5% hyaluronic acid with an average viscosity of s). [Background technology]

[0002] Many consumers desire skincare products containing sodium hyaluronate, particularly relatively high levels of sodium hyaluronate (e.g., ≥0.5%, ≥0.7%, ≥0.9%, or ≥1%). Sodium hyaluronate can increase skin hydration and reduce the appearance of fine lines and wrinkles.

[0003] Some consumers prefer sodium hyaluronate in serums, which are low-viscosity topical products, because they believe this product form may be particularly effective in delivering results quickly to the skin. Furthermore, serums generally have a light enough texture to be used under facial moisturizers, other facial treatments, or cosmetics.

[0004] Because serums can contain high concentrations of active ingredients, generally only a few drops are needed to deliver results to the entire face and / or neck, and therefore, many serums are dispensed from dropper packages. This packaging also allows consumers to customize their skincare regimen by adding drops to other products. Furthermore, attractive dropper packaging can convey effectiveness while also embodying luxury and fashion, just as droppers have traditionally been used in the pharmaceutical industry.

[0005] However, relatively high levels of sodium hyaluronate, when added to traditional serum formulations, unexpectedly build viscosity. This has been found to result in formulations that, when combined with one or more traditional polymer thickeners, are too viscous to be dispensed with a dropper and / or easily spread across the user's face. One way to reduce viscosity is to eliminate ingredients known to build viscosity (e.g., thickeners). However, serums require sufficient viscosity for physical stability (i.e., no phase separation) throughout the product's shelf life. [Overview of the Initiative] [Problems that the invention aims to solve]

[0006] Therefore, a physically stable serum containing a relatively high level of sodium hyaluronate that is compatible with a dropper dispenser is required. [Means for solving the problem]

[0007] A physically stable skincare serum composition comprising: (a) a continuous phase comprising (i) about 0.5% to about 1.5% sodium hyaluronate having a weight-average molecular weight of about 500,000 to about 1,000,000 Da; (ii) more than 0.7% of a thickening agent, which is a polyacrylamide polymer and copolymer; and (iii) water; and (b) a dispersed phase comprising silicone, wherein the composition has a viscosity of about 4,000 cP to 25,000 cP.

[0008] A physically stable skincare serum composition comprising (a) about 0.5% to about 1.5% sodium hyaluronate containing a weight-average molecular weight of about 700,000 to about 1,000,000 Da, (b) a thickening agent of more than 1%, which is a polyacrylamide polymer or copolymer, and (c) water, wherein the composition has a viscosity of about 4,000 cP to 25,000 cP. [Brief explanation of the drawing]

[0009] While this specification concludes with claims that particularly point out and distinctly claim the subject matter of the invention, it is believed that the invention will be better understood from the following description in connection with the accompanying drawings. [Figure 1] It shows the influence on the viscosity of a simple system when adjusting the weight average molecular weight of 1% sodium hyaluronate.

DETAILED DESCRIPTION OF THE INVENTION

[0010] Hyaluronic acid is a biopolymer that occurs naturally in the skin and is a natural mucopolysaccharide formed by binding N-acetyl-O-glucosamine to glucuronic acid. Sodium hyaluronate is the sodium salt of hyaluronic acid and can be used in skin care products.

[0011] Many consumers desire skin care compositions containing sodium hyaluronate because it can regulate the water in the surface cells of the skin and keep the skin hydrated throughout the day. The mechanism by which hyaluronic acid and its salts hydrate the skin can also help reduce the appearance of fine lines and wrinkles.

[0012] Many currently commercially available skin care compositions contain relatively low levels of sodium hyaluronate. Some consumers desire skin care compositions having relatively high levels (e.g., ≥0.5%, ≥0.7%, ≥0.9%, or ≥1%) of sodium hyaluronate and may wish to achieve more moisture and / or anti-aging benefits. Many consumers desire to apply a skin care composition having sodium hyaluronate in a lotion, which is a low-viscosity topical emulsion product that can be applied by a dropper.

[0013] However, it can be difficult to formulate a serum that has (1) sufficiently low viscosity (so that it is easy to dispense with a dropper and spread over the user's face and / or neck), (2) a hydrophobic emollient such as silicone that increases consumer satisfaction during use, and (3) physical stability.

[0014] It was discovered that approximately 1% sodium hyaluronate unexpectedly builds viscosity in the composition. Furthermore, surprisingly, the amount of viscosity built was found to correlate with the weight-average molecular weight (Mw) of sodium hyaluronate.

[0015] The figure shows the effect of the weight-average molecular weight of approximately 1% sodium hyaluronate on the average viscosity in a simple system (containing 7% glycerin, 1% sodium hyaluronate, and the remainder water). The figure shows that viscosity increases as the Mw of sodium hyaluronate increases.

[0016] The weight-average molecular weight was provided in the supplier's certificate of analysis. The average viscosity was determined according to the following method: After holding the sample at approximately 25°C for at least 24 hours, the viscosity for the simple system was measured. The viscosity of the examples was measured at 25°C using a DV2T™-RV viscometer (available from Brookfield Engineering Laboratories, Middleboro, Massachusetts) with an RV3 spindle rotating at 5 rpm. The spindle was fully submerged 2.5–3.0 cm below the surface of the composition. The spindle was rotated for 30 seconds before starting data acquisition, then one data point was collected every 10 seconds for 5 readings, and the readings were averaged (mean) to determine the average viscosity.

[0017] Therefore, simply adding relatively high levels of sodium hyaluronate to a serum formulation, especially one containing one or more thickeners, can result in a product with unexpectedly high viscosity. Traditionally, product viscosity can be reduced by removing the thickener from the formulation. However, when a thickener is removed from a serum, it may become physically unstable, causing sodium hyaluronate, emollients, and other skincare active ingredients to leach out of the serum emulsion, which may appear as different layers in the serum product.

[0018] Next, the formulations described in Table 1 below were prepared, and the stability and viscosity of the products were evaluated in combination with different levels of thickeners (polyacrylamide, C13-14 isoparaffin, and laureth-7, commercially available from Seppic® Corporation as Sepigel® 305) with 1% sodium hyaluronate having different weight-average molecular weights. The results are summarized in Table 2 below. After storing the compositions at 60°C for two weeks, both the average viscosity and stability were determined.

[0019] [Table 1] 1. The weight-average molecular weights were 511,000 Da, 615,000 Da, 855,000 Da, or 920,000 Da, as shown in Table 2 below. 2. Sepigel (trademark) 305 from Seppic (registered trademark) Corporation 3. DC1503 from Dow Corning (registered trademark)

[0020] The average viscosity was determined by the viscosity test method described herein.

[0021] The weight-average molecular weight of sodium hyaluronate was provided in the supplier's analytical certificate.

[0022] If no phase separation was detected by visual inspection, the embodiment was physically stable. As used herein, “visual inspection” means that, under illumination at least equivalent to that of a standard 100-watt incandescent bulb, a human observer from 30 cm can visually identify, with the naked eye (except for standard corrective lenses fitted to correct myopia, hyperopia, or astigmatism, or other corrective vision), whether the product has separated into two distinct layers in a 2-ounce clear glass bottle.

[0023] [Table 2]

[0024] Table 2 shows that the average product viscosity increases as the concentration of Sepigel® 305 increases and as the Mw of sodium hyaluronate increases. Furthermore, when using sodium hyaluronate with a higher Mw, the composition could contain less thickener. For example, compositions with sodium hyaluronate having average Mws of 855,000 Da and 920,000 Da were stable with 0.9% and 1.2% Sepigel® 305 thickener, respectively. However, compositions with sodium hyaluronate having average Mws of 511,000 Da and 615,000 Da were unstable with both 0.9% and 1.2% Sepigel® 305 thickener. These compositions were stable when 1.8% thickener was added.

[0025] Next, formulations were prepared to test the functionality of the dropper packaging. For functionality to be effective, the dropper packaging must dispense a sufficient amount of product without excessive effort. The formulations were tested according to the formulations in Table 1 using 1.8% thickener (polyacrylamide & C13-14 isoparaffin & laureth-7, commercially available from Seppic® Corporation as Sepigel® 305) and 1% sodium hyaluronate with Mw having 920,000 Da (hereinafter, "high viscosity example"). The formulations were placed in the same dropper packaging as Olay® Regenerist® Retinol24® Night Facial Serum ("Retinol24®"). The weight of each dose from the dropper was compared to the weight of the dose from the dropper of Retinol24®, and Retinol24® is a successful commercially available facial serum product with ease of handling and a consumer-acceptable dose. The flexible top of the dropper was pressed to squeeze out the air, the tip was dipped into the serum, and then the pressure on the top was released. The low pressure inside the dropper drew up the liquid, allowing the dose to be collected. The weight of the dose was then measured. The results are summarized in Table 3 below.

[0026] [Table 3]

[0027] The product was deemed acceptable to consumers if the amount dispensed from the dropper was within ±15% of the droplet size of Retinol24® serum. The amount dispensed from the high-viscosity examples was within ±15% of the amount of Retinol24® serum and was easy to dispense. Therefore, the high-viscosity examples are acceptable to consumers, and the other physically stable examples in Table 2 are also expected to be acceptable to consumers because they have lower viscosity than the high-viscosity examples.

[0028] Unless otherwise specifically stated, all percentages are by weight of the cosmetic composition. Unless otherwise specifically stated, all ratios are by weight. All ranges include endpoints and are combinable. Significant digits do not represent limitations on the quantities indicated or on the precision of the measurements. Unless otherwise specifically stated, all quantities are understood to be modified by the word "approximately". Unless otherwise specified, all measurements are understood to have been made under ambient conditions of approximately 25°C, where "ambient conditions" means conditions of approximately 1 atmosphere and approximately 50% relative humidity. All numerical ranges include narrower ranges. Divided upper and lower range limits are interchangeable in creating further ranges that are not explicitly defined.

[0029] definition "Effective dose" means the amount of compound and composition sufficient to significantly induce a positive effect on keratinous tissue over the course of the treatment period. The positive effect may be a health, appearance, and / or tactile effect, including, individually or in combination, the effects disclosed herein. Specifically, an effective dose of vitamin B3 compound is sufficient to improve the health and / or appearance of psoriatic skin during the treatment period. In some cases, the effective dose may be demonstrated using ex vivo and / or in vitro methods.

[0030] "To improve the appearance of ~" means to provide a measurable and desirable change or effect on the appearance of the skin, which can be quantified, for example, by a reduction in redness, inflammation, and / or plaque scaling.

[0031] "A safe and effective dose" means an effective amount of an ingredient that is low enough to avoid serious side effects (within the bounds of sound medical judgment).

[0032] "Skincare" means the control and / or improvement of skin condition. Some non-exclusive examples include improving the appearance and / or feel of the skin by providing a smoother, more uniform appearance and / or feel; increasing the thickness of one or more layers of skin; improving skin elasticity or resilience; improving skin firmness; reducing the oily, shiny and / or dull appearance of the skin; improving the moisture content or hydration of the skin; improving the appearance of fine lines and / or wrinkles; improving exfoliation or desquamation of the skin; plumping the skin; improving skin barrier properties; improving skin tone; reducing the appearance of redness or skin blemishes; and / or improving skin brightness, radiance or clarity.

[0033] "Skincare active substances" refers to compounds or combinations of compounds that, when applied to the skin, produce acute and / or chronic effects on the skin or a type of cell normally found in the skin. Skincare active substances can modulate and / or improve the skin or related cells (e.g., improve skin elasticity, skin moisture content, skin barrier function, and / or cellular metabolism).

[0034] "Skincare composition" means a composition that contains skincare active substances and modulates and / or improves the condition of the skin.

[0035] As used herein, “treatment period” means the length of time and / or frequency at which the material or composition is applied to the target skin surface.

[0036] composition The skincare composition may be a serum with a viscosity sufficient for physical stability, thin enough to be dispensed by a dropper and easily spread over the user's face and / or neck. The average viscosity is 3000 cP (3 Pa). * s) More than 4000 cP (4 Pa) * s) More than 4500 cP (4.5 Pa) * s) More than 5000 cP (5 Pa) *s) can be more than. The average viscosity is 25,000 cP (25 Pa * s) less than, alternatively 20,000 cP (20 Pa * s) less than, alternatively 18,000 cP (1.8 Pa * s) less than, alternatively 15,000 (15 Pa * s) less than, alternatively 13,000 (13 Pa * s) less than, or alternatively 10,000 (10 Pa * s) can be less than. The average viscosity is about 3000 cP (3 Pa * s) to about 25,000 cP (25 Pa * s), alternatively about 3500 cP (3.5 Pa * s) to about 20,000 cP (20 Pa * s), alternatively about 4000 cP (4 Pa * s) to about 15,000 cP (15 Pa * s), alternatively about 5000 cP (5 Pa * s) to about 10,000 cP (10 Pa * s) can be. The average viscosity can be determined by the viscosity test method described hereinafter.

[0037] The composition can contain 0.5% or more, alternatively 0.6% or more, alternatively 0.7% or more, alternatively 0.8% or more, alternatively 0.9% or more, alternatively 1.0% or more of sodium hyaluronate. The composition can contain about 0.5% to about 5%, alternatively about 0.6% to about 4%, alternatively about 0.75% to about 3%, alternatively about 0.9% to about 2%, alternatively about 1% to about 1.5% of sodium hyaluronate.

[0038] Sodium hyaluronate may have Mw of approximately 200,000 Da to approximately 1,500,000 Da, alternatively approximately 300,000 Da to approximately 1,250,000 Da, alternatively approximately 400,000 Da to approximately 1,000,000 Da, and alternatively approximately 500,000 Da to approximately 950,000 Da. Sodium hyaluronate may have Mw of less than 3,000,000 Da, alternatively less than 2,000,000 Da, and alternatively less than 1,000,000 Da. Sodium hyaluronate may have Mw of more than 100,000 Da, alternatively more than 200,000 Da, alternatively more than 300,000 Da, alternatively more than 400,000 Da, and alternatively more than approximately 500,000 Da. The Mw of sodium hyaluronate can be determined according to the method described in the European Pharmacopoeia (European Pharmacopoeia 9.0.Sodium Hyaluronate.01 / 2017) (hereinafter referred to as "European Pharmacopoeia").

[0039] The skincare composition may contain approximately 1% sodium hyaluronate with an Mw of approximately 300,000 Da to approximately 1,000,000 Da, alternatively approximately 400,000 Da to approximately 950,000 Da, alternatively approximately 500,000 Da to approximately 920,000 Da, alternatively approximately 505,000 Da to approximately 855,000 Da, or alternatively approximately 510,000 Da to approximately 620,000 Da, and a thickener of more than 1.6%, alternatively more than 1.7%, alternatively more than 1.75%, or alternatively about 1.8% or more.

[0040] The skincare composition may contain approximately 1% sodium hyaluronate with an Mw of approximately 500,000 Da to approximately 1,000,000 Da, alternatively approximately 550,000 Da to approximately 950,000 Da, alternatively approximately 575,000 Da to approximately 920,000 Da, alternatively approximately 600,000 Da to approximately 855,000 Da, alternatively approximately 610,000 Da to approximately 800,000, alternatively approximately 615,000 Da to approximately 750,000 Da, or alternatively approximately 615,000 Da to approximately 700,000 Da, and more than 1.5% of a thickening agent, alternatively more than 1.55% of a thickening agent, or alternatively 1.6% or more of a thickening agent.

[0041] The skincare composition may contain approximately 1% sodium hyaluronate with an Mw of approximately 700,000 Da to approximately 2,000,000 Da, alternatively approximately 750,000 Da to approximately 1,500,000 Da, alternatively approximately 800,000 Da to approximately 1,250,000 Da, alternatively approximately 825,000 Da to approximately 1,000,000 Da, alternatively approximately 850,000 Da to approximately 950,000 Da, or alternatively approximately 855,000 Da to approximately 920,000 Da, and a thickener of more than 0.5%, alternatively more than 0.75%, more than 0.8%, more than 0.85%, or alternatively more than 0.9%.

[0042] The skincare composition may be phthalate-free, paraben-free, dye-free, synthetic fragrance-free, and / or fragrance-free.

[0043] Thickening agent Any or any combination of three compositions may contain one or more thickeners. A composition may contain more than 0.5%, alternatively more than 0.7%, alternatively more than 0.9%, alternatively more than 1.0%, alternatively more than 1.1%, or alternatively 1.2% or more of thickeners. A composition may contain 2% or less of thickeners, alternatively 1.9% or less of thickeners, or alternatively 1.8% or less of thickeners. A composition may contain about 1% to about 2%, alternatively about 1.2% to about 2.5%, alternatively about 1.3% to about 2.2%, alternatively about 1.4% to about 2.0%, or alternatively about 1.5% to about 1.8% of thickeners. Preferred classes of thickeners include, but are not limited to, carboxylic acid polymers, polyacrylamide polymers, sulfonated polymers, copolymers thereof, hydrophobic modified derivatives thereof, and mixtures thereof. The thickeners may be polyacrylamide polymers and copolymers.

[0044] Suitable thickeners include carbomers (e.g., CARBOPOL® 900 series such as CARBOPOL® 954), and carboxylic acid polymers such as Ultrez 10 and Ultrez 30. Other suitable carboxylic acid polymers include C 10~30 Alkyl acrylates, acrylic acid, methacrylic acid, or their short chains (i.e., C 1~4Examples include copolymers of one or more monomers of alcohol esters, with crosslinking agents being sucrose or pentaerythritol allyl ethers. These copolymers are acrylate / C 10~30 It is known as an alkyl acrylate crosspolymer and is commercially available from Noveon, Inc. as CARBOPOL® 1342, CARBOPOL® 1382, Ultrez 20, Ultrez 21, PEMULEN TR-1, and PEMULEN TR-2.

[0045] Other suitable thickeners include polyacrylamide polymers and copolymers. An exemplary polyacrylamide polymer has the CTFA designation "Polyacrylamide, Isoparaffin, and Laureth-7" and is available from Seppic® Corporation (Fairfield, NJ) under the trade name SEPIGEL 305. Other polyacrylamide polymers useful herein include multiblock copolymers of acrylamide and substituted acrylamide with acrylic acid and substituted acrylic acid. Examples of commercially available multiblock copolymers include HYPAN SR150H, SS500V, SS500W, and SSSA100H from Lipo Chemicals, Inc. (Patterson, NJ).

[0046] Other suitable thickeners useful herein include sulfonated polymers, such as sodium polyacryloyldimethyl taurate in CTFA notation, available from Seppic® Corp. under the trade name Simulgel 800, and Viscolam® at 100 P, available from Lamberti SpA (Gallarate, Italy). Another commercially available substance containing a sulfonated polymer is Sepiplus® 400, available from Seppic® Corp.

[0047] Furthermore, suitable thickeners may include superabsorbent polymers. These superabsorbent polymers include cross-linked sodium polyacrylate, for example, those marketed by Avecia® under the names Octacare X100, X110, and RM100; those marketed by SNF® under the names Flocare GB300 and Flosorb 500; those marketed by BASF® under the names Luquasorb 1003, Luquasorb 1010, Luquasorb 1280, and Luquasorb 1100; those marketed by Grain Processing® under the names Water Lock G400 and G430 (INCI name: acrylamide / sodium acrylate copolymer); or sodium acrylate crosspolymer-2, provided by Sumitomo Seika, Aqua Keep® 10 SH NF, Aqua Keep® 10 SH NFC, acrylic polymers (homopolymers or copolymers), and starch grafted particularly with sodium polyacrylate, for example, Sanfresh The superabsorbent polymers can be selected from those sold by Sanyo Chemical Industries® as ST-100C, ST100MC, and IM-300MC; Makimousse 12 and Makimousse 25 (INCI name: sodium polyacrylate starch) supplied by Kobo Products Inc.; acrylic polymers (homopolymers or copolymers), particularly hydrolyzed starch grafted with acryloacrylamide / sodium acrylate copolymer, such as those sold by Grain Processing® (INCI name: starch / acrylamide / sodium acrylate copolymer) under the names Water Lock A-240, A-180, B-204, D-223, A-100, C-200, and D-223. Preferred superabsorbent polymers include Makimousse 12 and Makimousse 25.

[0048] Suitable thickeners for use herein include gums. "Gum" is a broadly defined term in the art. Examples of gums include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, derivatives thereof, and mixtures thereof.

[0049] Natural gums are naturally occurring polysaccharides that can significantly increase viscosity in solution, even at low concentrations. They can be used as thickeners, gelling agents, emulsifiers, and stabilizers. In most cases, these gums are found in the woody elements or seed coats of plants. Natural gums can be classified according to their origin. They can also be classified as uncharged or ionic polymers (polyelectrolytes), examples of which include: Natural gums obtained from seaweed, e.g.: agar, alginic acid; sodium alginate, and carrageenan. Natural gums obtained from non-marine plant resources include gum arabic from the sap of the acacia tree, ghati gum from the sap of the anogeisus tree, tragacanth gum from the sap of the astragalus shrub, and karaya gum from the sap of the sterculia tree. Examples of uncharged gums include guar gum from guar beans, locust bean gum from carob tree seeds, β-glucan from oats or wheat bran, chicle gum, an older base for chewing gum obtained from chicle trees, dammar gum from dipterocarp sap, glucomannan from konjac plants, mastic gum, an ancient Greek chewing gum obtained from mastic trees, psyllium seed husks from plantago plants, spruce gum, an American Indian chewing gum obtained from spruce trees, and tara gum from tara tree seeds. Natural gums produced by bacterial fermentation include gellan gum and xanthan gum.

[0050] Vitamin B3 compounds The compositions described herein may contain a safe and effective amount of vitamin B3 compound. In some cases, the compositions of the present invention may contain 0.01% to 10% by weight (e.g., 0.1% to 10%, 0.5% to 5%, or further 1% to 3%) of vitamin B3 compound based on the weight or volume of the composition.

[0051] As used herein, "vitamin B3 compound" means a compound having the following formula:

[0052] [ka] In the formula, R means a compound, a derivative thereof, or a salt of any of the aforementioned, where R is CONH2 (i.e., niacinamide), COOH (i.e., nicotinic acid), or CH2OH (i.e., nicotinyl alcohol).

[0053] Exemplary derivatives of vitamin B3 compounds include nicotinic acid esters, which include non-vasodilatory esters of nicotinic acid (e.g., tocopheryl nicotinate, myristyl nicotinate), nicotinamide riboside, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, and niacinamide N-oxide.

[0054] Dermatologically acceptable carriers The compositions described herein include a dermatologically acceptable carrier (which may be referred to as the "carrier"). The term "dermatologically acceptable carrier" means that the carrier is suitable for topical application to keratinous tissue, has good aesthetic properties, is compatible with the active substances in the composition, and does not raise any unreasonable concerns regarding safety or toxicity. In one embodiment, the carrier is present in concentrations of about 50% to about 99% by weight, about 60% to about 98% by weight, about 70% to about 98% by weight, or alternatively, about 80% to about 95% by weight of the composition.

[0055] Carriers can take a wide variety of forms. In some cases, the form and characteristics of a carrier can be determined by the solubility or dispersibility of its components (e.g., extracts, sunscreens, additional components). Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, sticks, fluid solids, or amorphous materials). In some cases, dermatologically acceptable carriers are in the form of emulsions having a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water emulsions) or a continuous oil phase (e.g., water-in-oil or oil-in-water emulsions). The oil phase of the emulsion may include silicone oils, non-silicone oils (hydrocarbon oils, esters, ethers, etc.), and mixtures thereof. The aqueous phase may include water and water-soluble components (e.g., water-soluble humectants, conditioning agents, antimicrobial agents, wetting agents, and / or other skincare active ingredients). In some cases, the aqueous phase may contain components other than water, including but not limited to water-soluble humectants, conditioning agents, antimicrobial agents, wetting agents, and / or other water-soluble skincare active substances. In some cases, the non-aqueous components of the composition include wetting agents such as glycerin and / or other polyols. The composition may contain wetting agents in amounts of about 1% to about 15%, alternatively about 3% to about 10%, alternatively about 4% to about 9%, and alternatively about 5% to about 8%.

[0056] In some cases, the compositions herein are in the form of oil-in-water ("oil-in-water, O / W") emulsions that provide a light, non-greasy feel. Preferred O / W emulsions herein may contain more than 50% by weight of a continuous aqueous phase, with the remainder being a dispersed oil phase. The aqueous phase may contain 1% to 99% water, based on the weight of the aqueous phase, along with any water-soluble and / or water-miscible components. In these cases, the dispersed oil phase is typically present in less than 30% by weight of the composition (e.g., 1% to 20% by weight, 2% to 15% by weight, 3% to 12% by weight, 4% to 10% by weight, or even 5% to 8% by weight) to help avoid some of the undesirable tactile effects of the oily composition. The oil phase may contain one or more volatile and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils). Some non-limiting examples of oils that may be suitable for use in this composition are disclosed in U.S. Patent No. 9,446,265 and U.S. Patent Application Publication No. 2015 / 0196464.

[0057] The carrier may contain one or more dermatologically acceptable diluents. As used herein, “diluent” means a substance that can disperse, dissolve, or otherwise incorporate the skincare active ingredients herein. Some non-exclusive examples of hydrophilic diluents include water, lower monohydric alcohols (e.g., C1-C4), and organic hydrophilic diluents such as low molecular weight glycols and polyols, which include propylene glycol, polyethylene glycol (e.g., molecular weight 200-600 g / mol), polypropylene glycol (e.g., molecular weight 425-2025 g / mol), glycerol, butylene glycol, 1,2,4-butanetriol, sorbitol esters, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitol esters, butanediol, etherpropanol, ethoxylated ethers, propoxylated ethers, and combinations thereof.

[0058] Silicone oil The composition may contain a silicone oil selected from volatile silicone oils, non-volatile silicone oils, and combinations thereof. The silicone oil may be in the dispersed phase. The composition may contain about 1% to about 10% of silicone oil, alternatively about 3% to about 8% of silicone oil, or alternatively about 4% to about 7% of silicone oil.

[0059] Volatile silicone oil Suitable volatile silicones include cyclic and linear volatile silicones. Descriptions of various volatile silicones can be found in Todd, et al., "Volatile Silicone Fluids for Cosmetics," 91 Cosmetics and Toiletries 27-32 (1976). Suitable cyclic volatile silicones include cyclic dimethylsiloxane chains containing an average of about 3 to about 5 silicon atoms, preferably about 4 to about 5 silicon atoms. Exemplary cyclic volatile silicones of various viscosities include Dow Corning DC244, DC245, DC344, and DC345; GE Silicones-OSi Specialties Volatile Silicone 7207 and Volatile Silicone 7158; and GE Silicones SF1202. Suitable linear volatile silicones include polydimethylsiloxanes containing an average of about 2 to about 8 silicon atoms. Examples of linear volatile silicones include the Dow Corning DC200 series, which have viscosities of 0.65 cst, 1.0 cst, and 2.0 cst. In certain embodiments, linear volatile silicones generally have a viscosity of about 4 centistokes or less at 25°C, and cyclic materials generally have a viscosity of less than 6 centistokes at 25°C.

[0060] Non-volatile silicone oil A suitable non-volatile silicone oil is polysiloxane. Non-volatile polysiloxane can have a viscosity of about 10 to about 1,000,000 centistokes at 25°C. Such polysiloxane can be represented by the following general chemical formula: R3SiO[R2SiO]xSiR3 In the formula, each R is independently selected from hydrogen or C1-30 linear or branched, saturated or unsaturated alkyl, phenyl or aryl, or trialkylsiloxy, and x is an integer from 0 to about 10,000. In certain embodiments, R is methyl or ethyl. Examples of commercially available polysiloxanes include polydimethylsiloxane, also known as dimethicone, such as the DM-Fluid series from Shin-Etsu, the Vicasil® series sold by Momentive Performance Materials Inc., and the Dow Corning® 200 series sold by Dow Corning Corporation. A specific example of a preferred polydimethylsiloxane is Dow Corning® 200 fluid (also sold as Xiameter® PMX-200 Silicone Fluids). A preferred dimethicone is represented by the following chemical formula: R3SiO[R2SiO]x[RR'SiO]ySiR3 In the formula, R and R' are each independently hydrogen, or a C1-30 linear or branched, saturated or unsaturated alkyl, aryl, or trialkylsiloxy, and x and y are each integers from 1 to 1,000,000. An example is alkyldimethicone, in which at least R' is a fatty alkyl (e.g., C12-22). A preferred alkyldimethicone is cetyldimethicone, in which R' is a C16 linear and R is methyl, and is commercially available from Dow Corning as 2502 Cosmetic Fluid.

[0061] Preferred non-volatile oils include dimethicone (polydimethylsiloxane), which preferably have a viscosity of 10 cst to 1000 cst, more preferably 15 cst to 400 cst, and most preferably 20 cst to 200 cst. The average chain length of these preferred dimethicone substances is about 12 to about 375 dimethylsiloxane units, more preferably about 20 to about 200 dimethylsiloxane units, and most preferably about 27 to about 125 dimethylsiloxane units. In one embodiment, the second composition will contain at least one non-volatile silicone oil. In such an embodiment, at least about 70% by weight of the non-volatile oil is non-volatile silicone oil. In another embodiment, at least about 80% by weight of the non-volatile oil is non-volatile silicone. In yet another embodiment, at least about 90% by weight of the non-volatile oil is non-volatile silicone oil.

[0062] Other optional components This composition may optionally contain one or more additional components commonly used in cosmetic compositions (e.g., colorants, skincare active ingredients, anti-inflammatory agents, sunscreens, emulsifiers, buffers, rheology modifiers, or combinations thereof), provided that the additional components do not undesirably alter the skin health or appearance effects provided by this composition. When incorporated into the composition, the additional components must be suitable for use in contact with human skin tissue without exhibiting excessive toxicity, incompatibility, instability, allergic reactions, etc. Some non-limiting examples of additional active substances include vitamins, minerals, peptides and peptide derivatives, sugar amines, sunscreens, oil control agents, microparticles, flavonoid compounds, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliants, skin whitening agents, sunless tanning agents, lubricants, anti-acne active substances, anti-cellulite active substances, chelating agents, anti-wrinkle active substances, anti-atrophy active substances, phytosterols and / or plant hormones, N-acyl amino acid compounds, antibacterial agents, and antifungal agents. In some examples, the composition may include fragrances, particularly natural fragrances, or colorants, particularly natural colorants.Other non-limiting examples of additional ingredients and / or skincare active substances that may be suitable for use herein include U.S. Patent Application Publications 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 00092408, 2008 / 0206373, 2010 / 0239510, 2010 / 0189669, and 2 This is explained in Patent Nos. 010 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146, and 2013 / 0022557, as well as in U.S. Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359, and 6,174,533.

[0063] If the compositions herein contain optional components, it may be desirable to select components that do not form complexes with other components in the composition, particularly pH-sensitive components such as niacinamide, salicylates, and peptides, or otherwise interact in an undesirable manner. If present, optional components may be included in amounts of 0.0001% to 50% by weight, 0.001% to 20% by weight, or even 0.01% to 10% by weight (e.g., 50% by weight, 40% by weight, 30% by weight, 20% by weight, 10% by weight, 5% by weight, 4% by weight, 3% by weight, 2% by weight, 1% by weight, 0.5% by weight, or 0.1% by weight) of the composition.

[0064] How to use The skincare serum composition may be applied to the face, neck, and / or parts thereof, or a combination thereof, at least once, twice, or more frequently per day during the treatment period. When applied twice a day, there should be an interval of at least 1 to 12 hours between the first and second applications. The composition is typically applied in the morning and / or before bedtime. The treatment period as used herein is ideally a period sufficient for sodium hyaluronate and / or other skincare active ingredients to improve the appearance of the skin. The treatment period may last for at least one week (e.g., about two, four, eight, or even twelve weeks). In some cases, the treatment period may extend to several months (i.e., three to twelve months). In some cases, the composition may be applied at least once or even twice a day for most of the days of the week (e.g., at least four, five, or six days a week) during a treatment period of at least two, four, eight, or twelve weeks.

[0065] The serum composition can be applied to a dry face after cleansing. The serum composition may include, but is not limited to, moisturizers and / or sunscreens, and can be applied before or after other skincare compositions.

[0066] The serum composition may be intended to help improve the appearance of fine lines and wrinkles. The serum composition may be stronger, longer-lasting, and up to twice as long as other commercially available products. The serum composition may leave the skin moisturized and supple. [Examples]

[0067] The examples in Table 4 below could be prepared by conventional methods for producing topical skincare emulsions. These examples can be prepared by combining aqueous phase components (e.g., sodium hyaluronate, glycerin, skincare active ingredients, chelating agents, actioxidants, preservatives, and emulsifiers) in a container and mixing until homogeneous. Oil phase components (e.g., oil containing silicone oil and emulsifiers) can be combined in a separate container and mixed until homogeneous. The oil phase can then be added to the aqueous phase, and the resulting emulsion can be subjected to high-shear mixing (e.g., Flacktek Speedmixer® or Rotor-Statamill). Finally, the remaining thickener can be added to the emulsion and mixed until homogeneous, and then, if present, a pH adjuster can be added, and the product can be subjected to high-shear mixing until homogeneous.

[0068] [Table 4] 1 1,2-Hexanediol and Caprylyl Glycol from Symrise® 2 Iodopropynyl butylcarbamate, PEG-4 laurate, PEG-4 dilaurate, and polyethylene glycol from Lonza® 3 From Lonza (registered trademark): DMDM ​​hydantoin, butane-1,3-diol, iodopropynyl butylcarbamate, water 4 Undecylenoyl phenylalanine from Seppic (registered trademark) Corporation 5 Water and hydrolyzed Serotonia silicula seed extract from Silab® 6 Water, glycerin, decyl glucoside, lactic acid, benzyl alcohol, and palmitoyl dipeptide-7 from Sederma®. 7PEG-7 Sodium Olive Oil Carboxylate from B&T Srl 8 Water, glycerin, PEG-100 stearate, benzyl alcohol, and palmitoyl pentapeptide-4 from Sederma®. 9 Polyacrylamide, C13-14 isoparaffin, and laureth-7 from Seppic (registered trademark) Corporation. 10 Sodium polyacrylate starch from Kobo® Products Inc. 12 Carbomer from Lubrizol (registered trademark) 13 Acrylate C10-30 alkyl acrylate crosspolymer from Lubrizol® 14 Dimethicone (and) Dimethicone Crosspolymer from Dow Corning® 15 Dimethicone (and dimethiconol) from Dow Corning®

[0069] Test method Viscosity Test Method After storage at 25°C for at least 24 hours, the product viscosity is measured using a DV2T-RV viscometer (available from Brookfield Engineering Laboratories, Middleboro, Massachusetts) equipped with a TC spindle rotating at 5 rpm at 25°C. The spindle is started 2.5–3.0 cm below the product surface, and the helipath is advanced downwards, collecting one reading every 9 seconds for five readings. The average (mean) of the readings is calculated to determine the average viscosity.

[0070] combination A. A physically stable skincare serum composition, a. Continuous phase, i. Sodium hyaluronate in an amount of approximately 0.5% to approximately 3%, comprising a weight-average molecular weight of approximately 500,000 to approximately 1,000,000 Da, preferably approximately 500,000 Da to approximately 920,000 Da, more preferably approximately 505,000 Da to approximately 855,000 Da, and even more preferably approximately 510,000 Da to approximately 620,000, according to the European Pharmacopoeia. ii. A thickening agent comprising more than 0.7%, preferably more than 1.0%, more preferably more than 1.1%, and even more preferably 1.2% or more, which is a polyacrylamide polymer or copolymer, and iii. A continuous phase containing water, b. A dispersed phase containing silicone, A composition having a viscosity of approximately 3,000 cP to 25,000 cP. B. A physically stable skincare serum composition, a. Sodium hyaluronate in an amount of approximately 0.5% to approximately 3%, comprising a weight-average molecular weight of approximately 700,000 Da to approximately 2,000,000 Da, preferably approximately 750,000 Da to approximately 1,500,000 Da, more preferably approximately 800,000 Da to approximately 1,250,000 Da, and even more preferably approximately 855,000 Da to approximately 920,000 Da, according to the European Pharmacopoeia. b. A thickening agent comprising more than 1%, more preferably more than 1.1%, and even more preferably 1.2% or more, which is a polyacrylamide polymer or copolymer, c. Water and, The above composition is approximately 3,000 cP (3 Pa). * s) ~25,000 cP (25 Pa) * A composition containing the average viscosity of s). C. The skincare composition is an emulsion comprising a continuous phase and a dispersed phase, wherein the continuous phase comprises sodium hyaluronate, a thickener, and water, and the dispersed phase comprises silicone, as described in paragraph B. D. The average viscosity is approximately 3000 cP (3 Pa) according to the viscosity test method described herein. * s)~Approx. 25,000cP(25Pa *s), preferably about 3500 cP (3.5 Pa) * s)~Approx. 20,000cP(20Pa * s), more preferably about 4000 cP (4 Pa) * s)~Approx. 15,000cP(15Pa * s), more preferably alternatively, about 5000 cP (5 Pa) * s)~Approx. 10,000cP(10Pa * The composition described in any one of paragraphs A to C, which is s). E. The composition according to any one of paragraphs A to D, wherein the composition comprises about 0.6% to about 2% sodium hyaluronate, preferably about 0.7% to about 1.5%, more preferably about 0.75% to about 1.25% sodium hyaluronate. F. The composition according to any one of paragraphs A to E, wherein the composition comprises 2% or less of a thickening agent, preferably 1.9% or less of a thickening agent, and preferably 1.8% or less of a thickening agent. G. The composition according to any one of paragraphs A to F, wherein the thickening agent comprises polyacrylamide, isoparaffin, and laureth-7. H. A composition according to any one of paragraphs A to G, wherein the composition does not contain phthalates, parabens, dyes, synthetic fragrances, and / or fragrances. I. The composition according to any one of paragraphs A to H, wherein the continuous phase further comprises about 3% to about 10% glycerin, preferably about 4% to about 9% glycerin, and more preferably about 5% to about 8% glycerin. J. The composition according to any one of paragraphs A to I, wherein the continuous phase further comprises niacinamide, nicotinic acid, nicotinyl alcohol, and a vitamin B3 compound selected from combinations thereof. K. A skincare product comprising a dropper package adapted for storing and dispensing the skincare serum composition described in any one of paragraphs A to J. L. Use of any one of paragraphs A to K for increasing skin hydration and / or reducing the appearance of fine lines or wrinkles. The dimensions and values ​​disclosed herein should not be understood as being strictly limited to the exact numerical values ​​listed. Instead, unless otherwise specified, each such dimension is intended to mean both the listed value and the functionally equivalent range encompassing that value. For example, a dimension disclosed as "40 mm" is intended to mean "approximately 40 mm."

[0071] All documents referenced herein, including any patents or patent applications that are cross-referenced or related, and any patent applications or patents on which this application claims priority or benefit thereof, are incorporated herein by reference in their entirety unless explicitly stated to be excluded or otherwise limited. No reference to any document shall be deemed to be prior art to any invention disclosed or claimed herein, nor shall it be deemed to teach, suggest or disclose any such invention, either alone or in combination with any other reference or any number of references. Furthermore, if any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in any document incorporated by reference, the meaning or definition given to that term in this document shall apply.

[0072] While specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications within the scope of the invention be covered in the appended claims.

Claims

1. A physically stable skincare serum composition, a. Continuous phase, i. Sodium hyaluronate in a 0.5% to 1.5% concentration, containing a weight-average molecular weight of 500,000 to 1,000,000 Da according to the European Pharmacopoeia, ii. A thickening agent comprising more than 0.7%, which is a polyacrylamide polymer or polyacrylamide copolymer, iii. A continuous phase containing water, b. A dispersed phase containing silicone, The composition comprises an average viscosity of 4,000 cP (4 Pa*s) to 25,000 cP (25 Pa*s) according to the viscosity test method described herein.

2. The composition according to claim 1, wherein the thickening agent comprises polyacrylamide, isoparaffin, and laureth-7.

3. The composition according to claim 1, wherein the composition does not contain phthalates, parabens, dyes, synthetic fragrances, and / or fragrances.

4. The composition according to claim 1, wherein the continuous phase further comprises 3% to 10% glycerin.

5. The continuous phase is a vitamin B selected from niacinamide, nicotinic acid, nicotinyl alcohol, and combinations thereof. 3 The composition according to claim 1, further comprising the compound.

6. The continuous phase is a vitamin B selected from niacinamide, nicotinic acid, nicotinyl alcohol, and combinations thereof. 3 The composition according to any one of claims 2 to 4, further comprising the compound.

7. The composition according to any one of claims 2, 4, or 5, wherein the composition does not contain phthalates, parabens, dyes, synthetic fragrances, and / or fragrances.

8. A skincare product comprising a dropper package adapted for storing and dispensing a skincare serum composition according to any one of claims 1 to 5.

9. Use of the skincare serum composition according to any one of claims 1 to 5 for increasing skin hydration and / or reducing the appearance of fine lines or wrinkles.

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