Pharmaceutical preparations for the prevention or treatment of pulmonary fibrosis

Abstract

The present invention relates to the medical use of the compound of formula 1 for the treatment or prevention of pulmonary fibrosis. The present invention also relates to a combination therapy of the compound of formula 1 with nintedanib.

Description

Technical Field

[0001] The present invention relates to a pharmaceutical preparation for treating or preventing pulmonary fibrosis. That is, the present invention relates to the pharmaceutical use of a specific compound for treating or preventing pulmonary fibrosis. Further, the present invention relates to a combined preparation for treating or preventing pulmonary fibrosis, that is, combination therapy.

[0002] This application claims priority based on Korean Patent Application No. 10-2021-0071130 filed on June 1, 2021, and all the contents disclosed in the specification and drawings of the said application are incorporated into this application.

Background Art

[0003] Pulmonary fibrosis is a disease in which the lungs gradually become stiff, their function deteriorates, and it leads to death due to dyspnea. The causes of occurrence include rheumatic diseases, radiation, mold, etc., and there is also idiopathic pulmonary fibrosis for which no specific cause is found.

[0004] Cases of lung tissue damage and fibrosis due to anticancer treatment or radiation exposure in industrial sites are very frequent. For example, radiation pneumonia occurs in 10 - 15% of patients who have received chest radiation therapy 2 - 3 months later, and progresses to a fibrotic disease, which is a late-onset side effect, 6 months later. Such advanced pulmonary fibrosis is irreversible and cannot be recovered.

[0005] The treatment method for pulmonary fibrosis is basically to take drugs that can delay the progression of fibrosis to the maximum extent, and in severe cases, lung transplantation must be considered. Currently, there are two clinically used prescription drugs for pulmonary fibrosis, pirfenidone and nintedanib.

[0006] On the other hand, in the case of combination therapy, which involves administering two drugs in combination, it is virtually impossible to predict the effects at the time of combination therapy. However, due to the various advantages of such combination therapy, such as the ability to reduce the dosage of each drug, research on combination formulations is urgently needed. [Overview of the project] [Problems that the invention aims to solve]

[0007] The present invention aims to provide a pharmaceutical formulation useful for the prevention or treatment of pulmonary fibrosis.

[0008] Another objective of the present invention is to provide a method for preventing or treating pulmonary fibrosis. [Means for solving the problem]

[0009] To achieve the above objectives, one aspect of the present invention provides a pharmaceutical formulation for the prevention or treatment of pulmonary fibrosis, comprising a pyrimidine-4-carboxamide compound of the following chemical formula 1 as an active ingredient.

[0010] [ka] The inventors of the present invention completed the present invention when they discovered during the development of pharmaceuticals for the prevention or treatment of pulmonary fibrosis that the compound 2-((R)-4-(2-fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide, represented by the above chemical formula 1, is very effective in alleviating pulmonary fibrosis.

[0011] The aforementioned compound is a compound contained in the chemical formula disclosed in International Patent Application Publication WO2011-139107. The aforementioned compound is an 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) enzyme inhibitor and is being studied primarily for therapeutic use in metabolic diseases such as diabetes and non-alcoholic steatohepatitis (International Patent Application Publication WO2020-022708).

[0012] The compound of chemical formula 1 can be produced by the method disclosed in International Patent Application Publication WO2011-139107.

[0013] Furthermore, the present invention provides a method for treating, improving, or preventing pulmonary fibrosis, characterized by administering a therapeutically or prophylactically effective amount of the compound of chemical formula 1 to an individual in need of treatment or prevention of pulmonary fibrosis. That is, the present invention provides a pharmaceutical use of the compound of chemical formula 1 for the treatment or prevention of pulmonary fibrosis.

[0014] As used herein, “prevention” includes preventing the recurrence, spread, or onset of pulmonary fibrosis in patients.

[0015] As used herein, “treatment” means eradicating, eliminating, or controlling pulmonary fibrosis, or minimizing or delaying the expansion of pulmonary fibrosis.

[0016] In one embodiment of the present invention, pulmonary fibrosis is pulmonary fibrosis induced by drug therapy (e.g., anti-cancer drug therapy) or radiation exposure. In another embodiment of the present invention, pulmonary fibrosis is idiopathic pulmonary fibrosis.

[0017] Another aspect of the present invention provides a pharmaceutical formulation for the prevention or treatment of pulmonary fibrosis, comprising the compound of chemical formula 1 as an active ingredient, and further comprising nintedanib (CAS number: 656247-17-5) or a pharmaceutically acceptable salt thereof as a second active ingredient. That is, another aspect of the present invention provides a combination formulation of the two active ingredients, i.e., a combination therapy thereof, for the prevention or treatment of pulmonary fibrosis.

[0018] The compound of chemical formula 1 and the nintedanib component synergistically enhance the therapeutic or preventive effects of pulmonary fibrosis.

[0019] As pharmaceutically acceptable salts of nintedanib, acid addition salts are available, including salts of the active compound prepared from relatively non-toxic acids. Acid addition salts are obtained by contacting the neutral form of such compound with a sufficient amount of the desired acid and a pure or suitable inert solvent. Examples of pharmaceutically acceptable acid addition salts include not only salts derived from relatively non-toxic organic acids, such as acetic acid, propionic acid, isobutyric acid, oxalic acid, maleic acid, malonic acid, benzoic acid, succinic acid, suberic acid, fumaric acid, mandelic acid, phthalic acid, benzenesulfonic acid, p-toluenesulfonic acid, citric acid, tartaric acid, methanesulfonic acid and its analogs, but also hydrogen chloride, hydrogen bromide, nitrous acid, carbonic acid, monocarbonate, phosphoric acid, monohydrogen phosphoric acid, dihydrogen phosphoric acid, sulfuric acid, monohydrogen sulfuric acid, hydrogen iodide or phosphorous acid and its analogs. Furthermore, it includes salts of amino acids such as alginates and their analogues, and analogues of organic acids such as glucuronic acid or galacturonic acid and their analogues. For example, ethanesulfonate of nintedanib may be used.

[0020] As used herein, the terms “compound of chemical formula 1” or “nintedanib” include not only the compound of chemical formula 1 and nintedanib, but also their clathrates, hydrates, solvates, or polymorphs (crystalline polymorphs).

[0021] As used herein, the term “polymorph” means a solid crystalline form of the compound of the present invention or a composite thereof. Other polymorphs of the same compound exhibit different physical, chemical, and / or spectral properties. Differences in physical properties include, but are not limited to, stability (e.g., thermal or photostability), compressibility and density (important for formulation and production of products), and solubility (may affect bioavailability). Differences in stability may result in changes in chemical reactivity (e.g., differential oxidation, such as discoloration occurring faster when composed of one polymorph than when composed of other polymorphs) or mechanical characteristics (e.g., a kinetically preferred polymorph, where fragments of a stored tablet are converted to a thermodynamically more stable polymorph) or both (a tablet of one polymorph is more sensitive to decomposition at high humidity). Other physical properties of polymorphs may affect their processing. For example, one polymorph may be more likely to form solvent compounds or be more difficult to filter or wash than other polymorphs, for example, due to its morphology or particle size distribution.

[0022] As used herein, the term "solvent compound" means the compound of the present invention containing a stoichiometric or non-stoichiometric amount of solvent bonded by non-covalent forces. The preferred solvent is volatile, non-toxic, and can be administered to humans in very small amounts.

[0023] As used herein, the term "hydrate" means a compound of the present invention that contains a stoichiometric or non-stoichiometric amount of water bound together by non-covalent forces.

[0024] As used herein, the term "clathrate" refers to the compound of the present invention having a crystalline lattice structure that includes spaces (e.g., channels) that confine guest molecules (e.g., solvents or water).

[0025] If a compound (prodrug) is separated from the body to produce the compound of the present invention, such a compound is also included in the scope of the present invention. As used herein, unless otherwise indicated, the term "prodrug" means an active compound, particularly a compound of the present invention that is hydrolyzed, oxidized, and capable of undergoing different reactions under biological conditions (in vitro or in vivo) to supply the compound of the present invention. Examples of prodrugs include biohydrolyzable amides, biohydrolyzable esters, biohydrolyzable carbamates, biohydrolyzable carbonates, biohydrolyzable ureides, and compounds containing biohydrolyzable moieties such as biohydrolyzable phosphate analogs that are biohydrolyzed to produce the compound of the present invention, but are not limited to these specific embodiments. Desirably, the prodrug of a compound having a carboxylic acid functional group is a lower alkyl ester of the carboxylic acid. Carboxylic acid esters are usually formed by esterifying a portion of the carboxylic acid present in the molecule. Prodrugs can be readily prepared using well-known methods as described in Burger’s Medicinal Chemistry and Drug Discovery 6th ed. (Donald J. Abrahamed., 2001, Wiley) and Design and Application of Prodrugs (H. Bundgaard ed., 1985, Harwood Academic Publishers Gmfh).

[0026] The compounds of the present invention are usually administered in a therapeutically effective amount.

[0027] The compounds of the present invention can be administered by any desired route, in the form of a pharmaceutical composition appropriate for such a route and in an effective dosage for the intended treatment. The effective dosage is usually about 0.01 to 50 mg / body weight (kg) / day, preferably about 0.05 to 20 mg / body weight (kg) / day, in single or divided doses. Depending on age, species, and the disease or condition to be treated, a dosage level below the lower limit of the above range may be desirable. In other cases, even higher dosages can still be used without harmful side effects. Higher dosages can be divided into several smaller dosages for administration during a day. Methods for determining appropriate dosages are well known in the field to which the present invention pertains.

[0028] In accordance with the combination therapy of the present invention, when two active ingredients are administered, the dosage of each active ingredient can be the same as the dosage when administered alone, or can be reduced by 10 to 30% by weight relative to the single administration. In one embodiment of the present invention, the compound of Chemical Formula 1 during combination can be administered at 0.1 to 1 part by weight relative to the dosage of nintedanib. The dosage of nintedanib is known in the field to which the present invention pertains (refer to the Ofev® dosage).

[0029] As described above, when two active ingredients are administered, they can be administered simultaneously (in the same dosage form or separate dosage forms) or sequentially. Therefore, in one embodiment, the present invention provides a method for treating or preventing pulmonary fibrosis by administering to an individual a therapeutically effective amount of the compound of Chemical Formula 1 and a therapeutically effective amount of nintedanib or a pharmaceutically acceptable salt thereof as the second active ingredient.

[0030] In one embodiment, one or all of the plurality of medicinal ingredients can be given in multiple doses. If not simultaneously, the timing of the multiple doses can arbitrarily vary from more than 0 weeks to less than 20 weeks.

[0031] Furthermore, the methods of combination, compositions, and dosage forms are not limited to the use of just two formulations, but also include combinations of multiple therapies. Dosage regimens for treating, preventing, or improving pathological conditions can be arbitrarily modified by a variety of factors. These factors include not only the individual's age, weight, sex, diet, and medical condition, but also the disorder the individual suffers from.

[0032] The pharmaceutical formulations comprising the combination therapies disclosed herein are optionally combined single formulations or separated formulations primarily for simultaneous administration. In this specification, the formulations may be kit formulations containing two separate active ingredients. Furthermore, the pharmaceutical formulations comprising the combination therapy may be administered sequentially in one of the formulations administered by a two-stage dosing therapy. The two-stage dosing therapy may require sequential administration of the activators or separated administration of the activators. The time period of the repeated dosing stage ranges from minutes to hours, depending on the characteristics of each pharmaceutical formulation, such as potency, solubility, bioavailability, plasma half-life, and kinetic profile. Circadian variation of the target molecule concentration is used to determine the optimal dosing interval.

[0033] In other embodiments, the present invention provides a pharmaceutical formulation comprising the compound of chemical formula 1 and a pharmaceutically acceptable carrier or additive, or a pharmaceutical formulation (compound formulation) comprising the compound of chemical formula 1, nintedanib or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or additive.

[0034] The term "pharmaceutically acceptable" means that it is suitable for use as a pharmaceutical preparation, is generally considered safe for such use, is officially approved for such use by a national regulatory body, or is listed in the catalog of the Korean Pharmacopoeia or the United States Pharmacopoeia.

[0035] For the treatment of the aforementioned disease or condition, the active ingredients described herein may be administered as follows: Multiple active ingredients according to the present invention may be contained together in one formulation described below, or multiple active ingredients may be contained in separate formulations and taken together.

[0036] Intranasal administration The active ingredient according to the present invention can be administered intranasally, and intranasal administration is particularly desirable for the pharmaceutical use of the present invention. In the present invention, such intranasal administration is a concept that includes conventional inhalation administration.

[0037] Such "intranasal administration" means the delivery of the composition to the nose and / or nasal cavity via one or both of the nose and / or nasal cavity, and includes delivery by spray or droplet mechanism or delivery by aerosolization of the active ingredient. Administration of the composition by inhalation may be carried out through the nose or mouth by spray or droplet mechanism.

[0038] For nasal or inhalation delivery, the compositions of the present invention may be formulated by methods well known to the skilled art. These may include, but are not limited to, typical solubilizers, diluents, or dispersions, such as saline solution, preservatives, such as benzyl alcohol, or absorption enhancers. Such liquid pharmaceutical compositions may be prepared in the same manner as the oral administration compositions described later.

[0039] Such nasal administration can be performed using known intranasal delivery devices in the field to which the present invention belongs, in which propellants such as fluorocarbons and hydrofluoroalkanes may be used.

[0040] Oral administration The compounds of the present invention are administerable orally, and the oral cavity is a concept that includes swallowing. Oral administration allows the compounds of the present invention to enter the gastrointestinal tract or to be absorbed directly into the bloodstream from the mouth, for example, by buccal or sublingual administration.

[0041] A preferred composition for oral administration may be solid, liquid, gel, or powder, and may have dosage forms such as tablets, lozenges, capsules, granules, or powders.

[0042] Compositions for oral administration may be selectively enteric-coated, and the enteric coating may result in delayed or sustained release. That is, compositions for oral administration according to the present invention may be dosage forms having immediate or modified release patterns.

[0043] Liquid dosage forms may include solutions, syrups, and suspensions, and such liquid compositions may be contained within soft or hard capsules. Such dosage forms may contain pharmaceutically acceptable carriers, such as water, ethanol, polyethylene glycol, cellulose, or oil. The dosage forms may also contain one or more emulsifiers and / or suspending agents.

[0044] In tablet form, the amount of the active ingredient, the drug, may be approximately 0.05 to 95% by weight of the total weight of the tablet, more commonly approximately 2 to 50% by weight of the dosage form. The tablet may also contain a disintegrant, which may be approximately 0.5 to 35% by weight, more commonly approximately 2 to 25% by weight of the dosage form. Examples of disintegrants include, but are not limited to, lactose, starch, sodium starch glycolate, crospovidone, croscarmellose sodium, maltodextrin, or mixtures thereof.

[0045] Lubricants included in the manufacturing of tablets may preferably be present in an amount of about 0.1 to 5% by weight and include, but are not limited to, talc, silicon dioxide, stearic acid, calcium, zinc or magnesium stearate, and sodium stearyl fumarate.

[0046] Examples of binders for manufacturing tablets include gelatin, polyethylene glycol, sugar, gum, starch, polyvinylpyrrolidone, hydroxypropyl cellulose, and hydroxypropyl methylcellulose. Desirable diluents for tablet manufacturing include, but are not limited to, mannitol, xylitol, lactose, dextrose, sucrose, sorbitol, starch, and microcrystalline cellulose.

[0047] Solubilizers that may be selectively included in tablets may be used in amounts of about 0.1 to 3% by weight relative to the total weight of the tablets. For example, polysorbates, sodium lauryl sulfate, sodium dodecyl sulfate, propylene carbonate, diethylene glycol monoethyl ether, dimethyl isosorbide, polyoxyethylene glycolated natural or hydrogenated castor oil, HCOR® (Nikkol), oleyl esters, Gelucire®, caprylic / caprylic / diglyceride, sorbitan fatty acid esters, and Solutol HS® may be used in the pharmaceutical compositions according to the present invention, but are not limited to these.

[0048] Parenteral administration The compounds of the present invention can be administered directly into the bloodstream, muscles, or internal organs. Preferred methods for parenteral administration include intravenous, intra-muscular, subcutaneous intra-arterial, intraperitoneal, intrathecal, and intracranial injections. Preferred devices for parenteral administration include injectors (including needles and needleless injectors) and infusion methods.

[0049] Compositions for parenteral administration may be in dosage forms having an immediate or modified release pattern, the modified release pattern may be a delayed or sustained release pattern.

[0050] Many parenteral dosage forms are liquid compositions, and such liquid compositions are aqueous solutions containing the pharmacoactive ingredient, salt, buffer, isotonic agent, etc., according to the present invention.

[0051] Parenteral dosage forms can be manufactured in a dried form (e.g., lyophilized) or as a sterile, non-aqueous solution. These dosage forms can be used with a suitable vehicle, such as sterile water. Solubility-enhancing agents can also be used in the preparation of parenteral solutions.

[0052] Topical Administration The compounds of the present invention can be administered topically via the skin or transderm. Dosage forms for such topical administration include lotions, solutions, creams, gels, hydrogels, ointments, foams, implants, patches, and the like. Pharmaceutically acceptable carriers for topical administration dosage forms may include water, alcohol, mineral oil, glycerin, polyethylene glycol, and the like. Topical administration can also be performed by electroporation, iontophoresis, phonophoresis, and the like.

[0053] Compositions for topical administration may be in dosage forms having an immediate or modified release pattern, the modified release pattern may be a delayed or sustained release pattern. [Effects of the Invention]

[0054] The present invention provides a pharmaceutical formulation useful for the treatment or prevention of pulmonary fibrosis, comprising a compound of chemical formula 1 as an active ingredient. That is, the present invention provides a pharmaceutical application of a compound of chemical formula 1 that is useful for the treatment or prevention of pulmonary fibrosis.

[0055] The present invention provides a pharmaceutical formulation useful for the treatment or prevention of pulmonary fibrosis, comprising two active ingredients: a compound of chemical formula 1 and nintedanib or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a synergistic combination therapy useful for the treatment or prevention of pulmonary fibrosis. [Brief explanation of the drawing]

[0056] [Figure 1] These are Masson's trichrome staining results of lung tissue at the radiation site after oral administration of each test substance to a mouse model of pulmonary fibrosis induced by radiation. [Figure 2]This graph shows the degree of collagen deposition quantified using an image program after microscopic imaging of lung tissue at the irradiated site in a mouse model of pulmonary fibrosis induced by radiation. [Figure 3] This graph shows the quantitative expression of the COL1A1 gene mRNA extracted from lung tissue using the qPCR method when each test substance was orally administered to a mouse model of pulmonary fibrosis induced by bleomycin. [Figure 4] This graph shows the quantitative TGFb gene mRNA expression obtained by qPCR after orally administering each test substance to a mouse model of pulmonary fibrosis induced by bleomycin, and then extracting RNA from lung tissue. [Figure 5] This graph shows the quantitative results obtained by orally administering each test substance to a mouse model of pulmonary fibrosis induced by bleomycin. After lysing lung tissue to obtain the lysate, the amount of hydroxyproline was measured using the ELISA method. [Modes for carrying out the invention]

[0057] The present invention will be described below with reference to specific examples. However, the examples of the present invention can be modified into many other forms, and the scope of the present invention should not be construed as being limited to the examples described below. The examples of the present invention are provided to give a more complete explanation of the present invention to a person of average skill in the industry.

[0058] Reference Example 1: Administration to an animal model of pulmonary fibrosis disease (irradiation). Male, 8-week-old mice from C57BL / 6 were orally administered the test substance, and one hour later, their chests were irradiated with a 3mm dose of radiation (90 Gy, 4mm collimator). Subsequently, the mice were orally administered the test substance twice daily for 14 days, after which they were necropsied. The lung tissue of the mice was fixed with 10% formalin, paraffin sections were prepared, and the degree of collagen deposition in the tissue was examined using trichrome staining. The composition of the test groups is shown in Table 1 below.

[0059] [Table 1]

[0060] Reference Example 2. Administration to an animal model of pulmonary fibrosis disease (bleomycin injection) C57BL / 6N mice were respiratoryly anesthetized with isoflurane. The airways were then exposed by making a central incision in the neck. Bleomycin dissolved in saline solution was gradually injected into the exposed upper airways at a rate of 1.25 mg / kg using an insulin syringe. The insulin syringe was then removed and the incision was sutured. The mice were then orally administered the test substance twice daily for 14 days, after which necropsy was performed. Left lung tissue was fixed with 10% formalin, and paraffin sections were prepared. The degree of pulmonary fibrosis was evaluated using H&E staining. The right lung tissue was lysed for qPCR and hydroxyproline measurement. The tissue was then used in each experiment to evaluate pulmonary fiber-related gene expression and the degree of collagen deposition in the lungs. The composition of the test groups is shown in Table 2 below.

[0061] [Table 2]

[0062] Example 1. Antifibrotic efficacy of the compound of chemical formula 1 in an animal model of pulmonary fibrosis. In accordance with Reference Example 1, a mouse model of radiation-induced pulmonary fibrosis was administered the test substance and then necropped. Mouse lung tissue was fixed in 10% neutral formalin for one day to create paraffin sections. To remove the paraffin around the tissue, it was sequentially treated with xylene and 95%, 90%, and 70% ethanol solutions for 5 minutes each. To activate the antigen in the tissue, it was immersed in a 0.1M citrate (pH 6.0) solution and boiled for 20 minutes. Next, it was sequentially treated with Bouin's solution for 1 minute, Weigert's hematoxylin for 10 minutes, phosphotungstic / phosphomolybdic acid for 10 minutes, aniline blue for 5 minutes, and 1% acetate for 1 minute. After dehydration, the samples were mounted on coverslips and observed under a microscope (Carl Zeiss Vision).

[0063] The test results, similar to those in Figures 1 and 2, confirmed anti-fibrotic efficacy in suppressing collagen deposition in all test substance administration groups against the vehicle (G1). Of these, the test groups showing high statistical significance were the nintedanib monotherapy group (G2) and the nintedanib combined with the compound of chemical formula 1 group (G4). In particular, the nintedanib combined with the compound of chemical formula 1 group (G4) showed superior efficacy compared to the nintedanib monotherapy group (G2).

[0064] In conclusion, the compound of chemical formula 1 significantly suppressed collagen deposition, a primary indicator of pulmonary fibrosis, and its effect was particularly superior when administered in combination with nintedanib compared to nintedanib alone.

[0065] Example 2. Antifibrotic efficacy of the compound of chemical formula 1 in an animal model of pulmonary fibrosis. Following Reference Example 1, a mouse model of pulmonary fibrosis induced by bleomycin was administered the test substance and necropsy was performed. Mouse lung tissue was fixed in 10% neutral formalin for one day to create paraffin sections. To remove the paraffin around the tissue, it was sequentially treated with xylene and 95%, 90%, and 70% ethanol solutions for 5 minutes each. Next, for trichrome staining, it was sequentially treated with Bouin's solution for 1 minute, Weigert hematoxylin for 10 minutes, phosphotungstic acid / phosphomolybdic acid for 10 minutes, aniline blue for 5 minutes, and 1% acetic acid for 1 minute. After dehydration, the tissue was mounted on a coverslip and observed under a microscope (Carl Zeiss Vision). Half of the right-sided necrotic lung tissue of the mouse was lysed for qPCR, RNA was extracted, and cDNA was synthesized. Subsequently, gene expression analysis of COL1A1, an extracellular matrix that causes fibrosis, and TGFβ, an important cytokine that causes fibrosis, was performed using qPCR equipment. The remaining half was analyzed using a hydroxyproline ELISA kit to obtain the lysate from the tissue.

[0066] In the test results, Figure 3 shows that while no statistically significant differences were observed when comparing COL1A1 gene expression in lung tissue, a decreasing trend was observed in all treatment groups compared to the vehicle (G2) group. Furthermore, in Figure 4, when comparing TGFβ gene expression, a significant difference was observed in all treatment groups compared to the vehicle treatment group (G2). In Figure 5, when examining hydroxyproline expression in lung tissue, a significant difference was observed in all treatment groups except the nintedanib monotherapy group (G7) compared to the vehicle treatment group (G2), and particularly favorable results were observed in the combination therapy group of nintedanib and the compound of chemical formula 1 (G6).

[0067] In conclusion, the compound of chemical formula 1 significantly suppressed collagen deposition, a primary indicator of pulmonary fibrosis, and its effect was particularly superior when administered in combination with nintedanib compared to nintedanib alone.

Claims

1. A pharmaceutical preparation for the prevention or treatment of pulmonary fibrosis, containing the compound of chemical formula 1 as an active ingredient. 【Chemistry 1】

2. The pharmaceutical preparation according to claim 1, wherein the pulmonary fibrosis is induced by drug therapy or radiation exposure.

3. The pharmaceutical preparation according to claim 1, wherein the pulmonary fibrosis is idiopathic pulmonary fibrosis.

4. The pharmaceutical preparation according to any one of claims 1 to 3, wherein the preparation further comprises nintedanib or a pharmaceutically acceptable salt thereof as an active ingredient.

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