Composition for caring for keratin substances

Abstract

A composition for caring for keratinous materials in the form of an oil-in-water cream, comprising: (i) 3% to 10.5% by weight, relative to the total weight of the composition, of at least one cosmetically active compound of formula (I), where R1, R2, and R3 are each independently selected from H, —OH, —CH2OH, and —CH2CH(OH)CH3, (ii) at least one water-soluble or water-dispersible copolymer derived from 2-acrylamidomethylpropanesulfonic acid and a non-ionic water-soluble comonomer (AMPS copolymer), (iii) at least one silicone compound, and (iv) ethanol. A non-therapeutic method for caring for keratinous materials, comprising the step of applying the composition to the keratinous materials. JPEG2023553635000019.jpg38170

Description

Technical Field

[0001] Technical Field The present invention relates to a cosmetic composition. In particular, the present invention relates to a composition for caring for keratinous substances. The present invention also relates to a non-therapeutic method for caring for keratinous substances.

Background Art

[0002] Background Art The skin is a protective barrier for the human body. The skin protects the interior of the body from physical injuries (e.g., trauma) and biological injuries (e.g., injuries caused by bacteria, viruses, or fungi). The epidermis is a keratinized, stratified, pavement-like epithelium. Its average thickness ranges from 60 to 100 μm and can reach 600 to 700 μm on the soles of the feet and palms of the hands. It consists mainly of keratinocytes but also of other cells and lies on the basement membrane that separates it from the dermis.

[0003] During menopause, the skin undergoes changes in all its compartments, namely the dermis and the epidermis.

[0004] The main changes are related to the dermis and include a decrease in collagen content and a reduction in the thickness of the dermis. In menopausal women, this leads to a vulnerability of the skin and / or mucosa. Subsequently, women experience a feeling of "dry skin" or taut skin, and it is also observed that surface wrinkles and fine wrinkles are accentuated. The skin has a rough texture. Finally, the skin shows a decrease in flexibility.

[0005] The main change regarding the epidermis is a decrease in keratinocyte differentiation, which results in a deficiency of the protein matrix of keratinocytes, the degradation of the extracellular matrix, an increase in metalloproteinases, which are proteases involved in skin aging, and also a decrease in the synthesis of various glycosaminoglycans.

[0006] The development of formulations dedicated to skin and / or lip care and / or makeup is endless.

[0007] A wide variety of cosmetic compositions are used to care for the skin, for example, to combat skin aging. There are commercially available anti-aging products containing proxylane, which, when the concentration of proxylane is relatively high, can give the skin a very sticky feeling. Consumers feel an unattractive oiliness after applying such products. Therefore, such products remain unsatisfactory. [Overview of the project] [Problems that the invention aims to solve]

[0008] Therefore, there is still a need to incorporate skin care compositions that are non-greasy and contain relatively high concentrations of proxylans, etc.

[0009] Furthermore, the composition is expected to have a relatively high viscosity as a cream. [Means for solving the problem]

[0010] Summary of the present invention Therefore, the applicant has discovered that it is possible to formulate such a composition having the desired properties described above.

[0011] Specifically, the applicant has discovered that it is possible to formulate a composition for caring for keratin substances, including proxylan at a relatively high concentration, while simultaneously having a relatively high viscosity as a cream without feeling sticky.

[0012] Therefore, in the first aspect, the present invention relates to a composition for caring for keratinous substances, in the form of an oil-in-water cream, and furthermore: (i) At least one cosmetic active compound of formula (I) in an amount of 3% to 10.5% by mass, relative to the total mass of the composition: [ka] (In the formula, R1, R2, and R3 are independently selected from H, -OH, -CH2OH, and -CH2CH(OH)CH3.) (ii) At least one water-soluble or water-dispersible copolymer (AMPS copolymer) derived from 2-acrylamidomethylpropanesulfonic acid and a nonionic water-soluble comonomer, (iii) at least one silicone compound, and (iv) Ethanol The present invention provides a composition containing [a certain substance].

[0013] The composition of the present invention is in the form of an oil-in-water cream. Therefore, the composition comprises a continuous aqueous phase and a dispersed oily phase.

[0014] In a second aspect, the present invention provides a non-therapeutic method for caring for a keratinous substance, comprising the step of applying a composition according to the first aspect of the present invention to the keratinous substance.

[0015] The composition of the present invention can provide an anti-aging effect to keratin substances without leaving a sticky feeling.

[0016] Furthermore, the composition according to the present invention is stable at 4°C, room temperature (25°C), and 45°C.

[0017] Furthermore, the composition according to the present invention has a relatively high viscosity, a smooth and fine texture as a cream, and good spreadability.

[0018] Other advantages of the present invention will become even clearer by reading the following description and examples. [Modes for carrying out the invention]

[0019] Detailed description of the present invention Unless otherwise defined, all technical and scientific terms used in this specification shall have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case the definitions of terms in this description conflict with the meanings commonly understood by one of ordinary skill in the art to which this invention belongs, the definitions described in this specification shall apply.

[0020] In the following description, unless otherwise indicated, the limiting values of a range of values are included within that range, particularly in the expressions "between ~ and ~" and "in the range from ~ to ~".

[0021] Furthermore, as used herein, the expression "at least one" is equivalent to the expression "one or more".

[0022] Throughout this application, the term "comprising" is to be interpreted as encompassing all specifically recited features, as well as any additional, unspecified features. When used in this specification, the use of the term "comprising" also discloses embodiments where there are no features other than those specifically recited (i.e., "consisting of").

[0023] Unless otherwise specified, all numerical values expressing amounts of components, etc. used in this specification and the claims are to be understood as being modified by the term "about". Accordingly, unless otherwise specified, the numerical values and parameters described in this specification are approximate values that can be changed as desired according to the desired purpose.

[0024] For the purposes of this invention, the term "keratinous substance" is intended to encompass human skin, mucous membranes, such as the lips. Facial skin is most particularly contemplated by the present invention.

[0025] All percentages in this invention refer to mass percentages, unless otherwise specified.

[0026] According to a first aspect, the present invention relates to a composition for caring for keratinous substances, in the form of an oil-in-water cream, (i) At least one cosmetic active compound of formula (I) in an amount of 3% to 10.5% by mass, relative to the total mass of the composition: [ka] (In the formula, R1, R2, and R3 are independently selected from H, -OH, -CH2OH, and -CH2CH(OH)CH3.) (ii) At least one water-soluble or water-dispersible copolymer (AMPS copolymer) derived from 2-acrylamidomethylpropanesulfonic acid and a nonionic water-soluble comonomer, (iii) at least one silicone compound, and (iv) Ethanol The present invention provides a composition containing [a certain substance].

[0027] Cosmetic active compound of formula (I) According to a first aspect, the composition of the present invention comprises at least one cosmetic active compound of formula (I): [ka] (In the formula, R1, R2, and R3 are independently selected from H, -OH, -CH2OH, and -CH2CH(OH)CH3).

[0028] In some embodiments, the composition according to the present invention includes, as a cosmetic active compound of formula (I), hydroxypropyltetrahydropyrantriol (Proxylan) (wherein R1 is -CH2CH(OH)CH3 and R2 and R3 are H), i.e., a compound of the following formula: [ka] Proxy Run.

[0029] In some embodiments, the composition according to the present invention includes, as a cosmetic active compound of formula (I), mannose (wherein R1 is -CH2OH, R2 is H, and R3 is -OH), i.e., a compound of the following formula: [ka] Mannose.

[0030] In some embodiments, the composition according to the present invention includes glucose (wherein R1 is -CH2OH, R2 is H, and R3 is -OH) as a cosmetic active compound of formula (I), i.e., a compound of the following formula: [ka] glucose.

[0031] In some embodiments, the composition according to the present invention includes, as a cosmetic active compound of formula (I), galactose (wherein R1 is -CH2OH, R2 is H, and R3 is -OH), i.e., a compound of the following formula: [ka] Galactose.

[0032] In some embodiments, the composition according to the present invention includes, as a cosmetic active compound of formula (I), fructose (wherein R1 is -CH2OH, R2 is -OH, and R3 is H), i.e., a compound of the following formula: [ka] Fructose.

[0033] In some preferred embodiments, the cosmetic active compound of formula (I) is selected from proxylan, mannose, glucose, galactose, fructose, and mixtures thereof.

[0034] Commercially available proxylan products include those sold by CHIMEX (NOVEAL) under the brand name MEXORYL SCN, which contain 35% by mass of proxylan.

[0035] It is advantageous for the cosmetic active compound of formula (I) to be present in the composition in an amount ranging from 3% to 8.75% by mass, preferably 3.15% to 4.2% by mass, based on the total mass of the composition.

[0036] AMPS copolymer According to a first aspect, the composition of the present invention comprises 2-acrylamidomethylpropanesulfonic acid and at least one water-soluble or water-dispersible copolymer (AMPS copolymer) derived from a nonionic water-soluble comonomer.

[0037] The term "water-soluble or water-dispersible" means a polymer that, when introduced into an aqueous phase at 25°C at a mass concentration equal to 1%, allows for the acquisition of a macroscopically homogeneous and transparent solution, i.e., a solution having a maximum light transmission value of at least 60%, preferably at least 70%, through a 1 cm thick sample at a wavelength equal to 500 nm.

[0038] A useful AMPS copolymer according to the present invention is a crosslinked or non-crosslinked copolymer comprising at least an acrylamide-2-methylpropanesulfonic acid monomer, in a form partially or completely neutralized with an inorganic base, such as ammonia, sodium hydroxide, or potassium hydroxide.

[0039] These are preferably completely neutralized or substantially completely neutralized, i.e., at least 90% neutralized.

[0040] If the polymer is crosslinked, the crosslinking agent can be selected from polyolefinic unsaturated compounds commonly used for crosslinking polymers obtained by free radical polymerization.

[0041] Examples of crosslinking agents that can be listed include divinylbenzene, diallyl ethers, dipropylene glycol diallyl ethers, polyglycol diallyl ethers, triethylene glycol divinyl ethers, hydroquinone diallyl ethers, ethylene glycol or tetraethylene glycol di(meth)acrylates, trimethylolpropane triacrylates, methylene bisacrylamide, methylene bismethacrylamide, triallylamine, triallyl cyanurate, diallyl maleate, tetraallylethylenediamine, tetraallyloxyethane, trimethylolpropane diallyl ethers, allyl(meth)acrylates, allyl ethers of sugar alcohols, or allyl ethers or vinyl ethers of other polyfunctional alcohols, as well as allyl esters of phosphoric acid derivatives and / or vinylphosphonic acid derivatives, or mixtures thereof.

[0042] According to one embodiment of the present invention, the crosslinking agent is selected from methylenebisacrylamide, allyl methacrylate, and trimethylolpropane triacrylate (TMPTA). The degree of crosslinking is generally in the range of 0.01 mol% to 10 mol%, particularly 0.2 mol% to 2 mol%, relative to the polymer.

[0043] The water-soluble or water-dispersible AMPS copolymer according to the present invention contains a nonionic water-soluble comonomer.

[0044] Examples of nonionic, water-soluble comonomers include: - (meth)acrylamide, - N-vinylacetamide and N-methyl-N-vinylacetamide, - N-vinylformamide and N-methyl-N-vinylformamide, - Maleic anhydride, - Vinylamine, - N-vinyllactams containing cyclic alkyl groups with 4 to 9 carbon atoms, for example, N-vinylpyrrolidone, N-butyrolactam and N-vinylcaprolactam. - Vinyl alcohol of formula CH2=CHOH, - Water-soluble vinyl monomer of the following formula (III): [ka] [In the formula, - R 15 It is selected from H, -CH3, -C2H5 and -C3H7. - X2 is -OR 16 Alkyl ether of type (where R 16 [These are selected from linear or branched, saturated or unsaturated hydrocarbon groups containing 1 to 6 carbon atoms, optionally substituted with halogen atoms (iodine, bromine, chlorine, or fluorine), hydroxyl groups (-OH), and ethers.]

[0045] Examples include glycidyl (meth)acrylate, hydroxyethyl (meth)acrylate, and (meth)acrylates of ethylene glycol or diethylene glycol.

[0046] The water-soluble or water-dispersible AMPS copolymer of the present invention preferably has a molar mass in the range of 50,000 g / mol to 1,000,000 g / mol, preferably 80,000 g / mol to 8,000,000 g / mol, and more preferably 1,000,000 g / mol to 7,000,000 g / mol.

[0047] Examples of water-soluble or water-dispersible AMPS copolymers according to the present invention include: - Copolymers of AMPS and vinylpyrrolidone or vinylformamide, optionally partially or completely neutralized with an inorganic base, such as ammonia, sodium hydroxide, or potassium hydroxide, such as the copolymer used in a commercially available product sold by Clariant under the name Aristoflex AVC (CTFA name: ammonium acryloyldimethyltaurate / VP copolymer), - Copolymers of AMPS and hydroxyethyl acrylate, such as AMPS / hydroxyethyl acrylate copolymer, for example, the copolymer used in a commercially available product sold by SEPPIC under the name EMT 10 (CTFA name: hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer).

[0048] Preferably, the AMPS copolymer is selected from copolymers of AMPS and vinylpyrrolidone or vinylformamide, which are optionally partially or completely neutralized with an inorganic base, such as ammonia, sodium hydroxide, or potassium hydroxide.

[0049] It is advantageous for the AMPS copolymer to be present in the composition in an amount ranging from 0.3% to 3% by mass, preferably 0.5% to 2% by mass, and more preferably 1% to 1.5% by mass, relative to the total mass of the composition.

[0050] Silicone compounds According to a first aspect, the composition of the present invention comprises at least one silicone compound.

[0051] Exemplary silicones include cyclic silicones, such as those having 3 to 6, 3 to 4, or 3 to 5 (or any of 3, 4, 5, or 6) Si-O groups in the cyclic main chain (e.g., siloxane). Exemplary cyclic silicones, but not limited to these, include cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane (e.g., cyclomethicone 5-NF), cyclohexasiloxane, and mixtures of cyclohexasiloxane and cyclopentasiloxane (e.g., DOW CORNING 246 Fluid (d6+d5)).

[0052] Exemplary silicones also include silicones having side groups or side chains.

[0053] In some embodiments, the side groups are hydrophobic. In some embodiments, the side groups are linear, while in other embodiments, the side groups are branched. Exemplary side chains include those having 1-6 or 2-6 or 3-6 or 3-6 or 5-6 carbon or heteroatoms (e.g., O, S, or N) (or any combination thereof). Exemplary linear side chains include methyl, ethyl, propyl, butyl, pentyl, and hexyl. Exemplary branched side chains, but not limited to these, include isopropyl, isobutyl, and tert-butyl. In one non-limiting embodiment, the branched side chain is -O-Si(CH3)3.

[0054] Preferably, the silicone compound is selected from C12-C22 alkyl or alkoxydimethicone, C6-C10 alkyl or alkoxylmethicone, and mixtures thereof.

[0055] More preferably, the silicone compound is selected from C16-C18 alkyl or alkoxydimethicone, C6-C10 alkyl or alkoxylmethicone, and mixtures thereof.

[0056] Most preferably, the silicone compound is selected from stearyl dimethicone, cetyl dimethicone, and caprylyl methicone, the structures of which are as follows: [ka] Stearyl dimethicone [ka] Cetyldimethicone [ka] Caprylyl methicone.

[0057] One example of a commercially available stearyl dimethicone product is the one sold by Evonik Goldschmidt under the brand name ABIL WAX 9800.

[0058] One example of a commercially available caprylyl methicone product is the one sold by Dow Corning (Dow Chemical) under the product name Dow Corning FZ-3196.

[0059] It is advantageous for the silicone compound to be present in the composition in an amount ranging from 0.05% to 6% by mass, preferably 0.5% to 5% by mass, and more preferably 2% to 4% by mass, relative to the total mass of the composition.

[0060] aqueous phase As an oil-in-water cream, the cosmetic composition of the present invention includes a continuous aqueous phase.

[0061] It is advantageous that the aqueous phase is present in an amount ranging from 50% to 95% by mass, preferably 55% to 90% by mass, and more preferably 60% to 85% by mass, of the total mass of the composition.

[0062] The aqueous phase comprises water and ethanol.

[0063] It is advantageous for water to be present in the composition of the present invention in an amount ranging from 20% to 80% by mass, preferably 30% to 75% by mass, relative to the total mass of the composition.

[0064] It is advantageous for ethanol to be present in the composition of the present invention in an amount ranging from 0.5% to 20% by mass, preferably 1% to 15% by mass, and more preferably 2% to 5% by mass, based on the total mass of the composition.

[0065] Preferably, the continuous aqueous phase includes water (at room temperature of 25°C) and additional miscible organic solvents, such as glycols and polyols having 2 to 20 carbon atoms, preferably 2 to 10 carbon atoms, and more preferably 2 to 6 carbon atoms, for example, glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol, diethylene glycol, and mixtures thereof.

[0066] Preferably, the continuous aqueous phase of the composition of the present invention comprises water, ethanol, butylene glycol, and glycerin.

[0067] oily phase As an oil-in-water cream, the composition of the present invention comprises at least one dispersed oily phase.

[0068] It is advantageous for the oily phase to be present in an amount of 1% to 40% by mass, preferably 2% to 30% by mass, and more preferably 3% to 20% by mass, relative to the total mass of the composition of the present invention.

[0069] The oily phase preferably comprises at least one additional oil in addition to the silicone compound mentioned above. The additional oil can be volatile or non-volatile.

[0070] The term "oil" refers to a water-immiscible, non-aqueous compound that is liquid at room temperature (25°C) and atmospheric pressure (760 mmHg).

[0071] The term "non-volatile oil" means that it can remain on keratinous material for at least several hours at room temperature and atmospheric pressure, especially 10 -3 This refers to oil with a vapor pressure of less than mmHg (0.13 Pa). Non-volatile oil is also defined as oil that evaporates at a rate of 0.07 mg / cm³ after 30 minutes under the previously defined conditions. 2 It can also be defined as having an evaporation rate less than [amount].

[0072] These oils may be of plant, inorganic, or synthetic origin.

[0073] The aforementioned additional oil may be selected from hydrocarbon oils or fluorinated oils.

[0074] The term "hydrocarbon oil" or "hydrocarbonized oil" means an oil that is essentially formed from or even composed of carbon and hydrogen atoms, and optionally from O and N atoms, and does not contain Si and F heteroatoms. Such oils may contain alcohols, esters, ethers, carboxylic acids, amines, and / or amide groups.

[0075] The term "fluorinated oil" refers to oil that contains at least one fluorine atom.

[0076] Preferably, in order to provide a moisturizing effect and obtain a good balance between viscosity and spreadability, the oily phase includes oils selected from coconut oil, caprylic / capric triglyceride, squalane, and mixtures thereof.

[0077] Additional cosmetic active ingredients The compositions of the present invention may contain additional cosmetic active ingredients in addition to the cosmetic active compound of formula (I) specified above.

[0078] Examples of active ingredients for cosmetics include moisturizers, e.g., protein hydrolysates; natural extracts; vitamins, e.g., vitamin A (retinol), vitamin E (tocopherol), vitamin C (ascorbic acid), vitamin B5 (panthenol), vitamin B3 (niacinamide), and derivatives (especially esters) of the vitamins and mixtures thereof; urea; caffeine; salicylic acid and its derivatives; alpha-hydroxy acids, e.g., lactic acid or glycolic acid and their derivatives; retinoids, e.g., carotenoids and vitamin A derivatives; sunscreens; extracts from algae, fungi, plants, yeasts and bacteria; enzymes; tightening agents; agents that act on the microcirculation, and mixtures thereof.

[0079] For those skilled in the art, it is easy to adjust the amount of additional cosmetic active ingredients based on the end use of the composition according to the present invention.

[0080] Additional adjuvants or additives The compositions of the present invention may contain, or may contain, conventional cosmetic adjuvants or additives, such as fragrances, chelating agents (e.g., tetrasodium glutamate diacetate and disodium EDTA), preservatives (e.g., chlorphenesin and phenoxyethanol), and bactericidal agents, emulsifiers, coemulsifiers (e.g., hydrogenated lecithin), additional thickeners (e.g., acrylate / C10-30 alkyl acrylate crosspolymer), pH adjusters (e.g., triethanolamine, citric acid, and sodium hydroxide), fillers (e.g., aluminum starch octenylsuccinate and polymethyl sesquioxane), and mixtures thereof.

[0081] In some embodiments, the compositions of the present invention include fillers selected from aluminum starch octenyl succinate, polymethyl cissesquioxane, and mixtures thereof to further reduce stickiness.

[0082] Those skilled in the art can select the amount of additional adjuvant or additive so as not to adversely affect the end use of the composition according to the present invention.

[0083] According to a particular preferred embodiment, the present invention provides a composition for caring for keratinous substances, in the form of an oil-in-water cream, wherein, with respect to the total mass of the composition, (i) 3.15% to 4.2% by mass of at least one cosmetic active compound selected from proxylane, mannose, glucose, galactose, fructose, and mixtures thereof. (ii) 1% to 1.5% by mass of at least one water-soluble or water-dispersible copolymer of AMPS and vinylpyrrolidone or vinylformamide, which is optionally partially or completely neutralized with an inorganic base, such as ammonia, sodium hydroxide, or potassium hydroxide. (iii) 2% to 4% by mass of at least one silicone compound selected from C16-C18 alkyl or alkoxydimethicone, C6-C10 alkyl or alkoxylmethicone, and mixtures thereof, (iv) 2% to 5% by mass of ethanol The present invention provides a composition containing [a certain substance].

[0084] Galen's morphology and methods The composition of the present invention is in the form of a cream.

[0085] Preferably, the composition according to the present invention has a viscosity in the range of 37 to 70 UD (in units of deviation), as measured at 25°C using a Rheomat 180 viscometer equipped with a spindle M3 rotating at 200 rpm.

[0086] The composition of the present invention can be used to care for keratinic substances.

[0087] According to a second aspect, the present invention provides a non-therapeutic method for caring for keratinous material, comprising the step of applying a composition according to a first aspect of the present invention to keratinous material.

[0088] In some embodiments, the present invention provides a non-therapeutic method for preventing aging of keratinous material, comprising the step of applying a composition according to a first aspect of the present invention to keratinous material.

[0089] The following examples illustrate the present invention, but are not inherently limiting. [Examples]

[0090] The main raw materials used, their names, and suppliers are listed in Table 1.

[0091] [Table 1]

[0092] (Example 1) The compositions of comparative formulations (Comp.) 1 to 4 and formulations (Inv.) 1 to 3 of the present invention were prepared according to the amounts shown in Table 2. The amounts are expressed as the mass % of the active ingredient relative to the total mass of the composition.

[0093] [Table 2]

[0094] The composition of Comparative Example 1 does not contain AMPS copolymer.

[0095] The composition of Comparative Example 2 does not contain ethanol.

[0096] The composition of Comparative Example 3 contains ammonium polyacryloyldimethyltaurate instead of the AMPS copolymer according to the present invention.

[0097] The composition of Comparative Example 4 contains an acrylate / C10-C30 alkyl acrylate crosspolymer instead of the AMPS copolymer according to the present invention.

[0098] Preparation method: The compositions listed above were prepared as follows, using the composition of formulation 1 of the present invention as an example: 1) Mix coconut oil (Cocos nucifera), shea butter, caprylyl methicone, and stearyl dimethicone to obtain an oily phase, and mix water, glycerin, butylene glycol, phenoxyethanol, tetrasodium glutamate diacetate, and hydrogenated lecithin to obtain an aqueous phase. 2) Heat the oily phase and the aqueous phase to 75°C. 3) Mix the oily phase and the aqueous phase to obtain a mixture, and homogenize the mixture at a high shear rate. 4) Next, add the polymer (ammonium acryloyldimethyltaurate / VP copolymer) to the mixture, and after the polymer has become sufficiently gel-like in water, gently stir and cool it to room temperature. 5) Add hydroxypropyltetrahydropyrantriol and ethanol at room temperature, and stir to disperse uniformly. 6) Adjust the pH to 5-6 by adding an appropriate amount of triethanolamine.

[0099] evaluation The viscosity of each resulting composition was measured at 25°C using a Rheomat 180 viscometer equipped with a spindle M3 rotating at 200 rpm.

[0100] The stability of each obtained composition was evaluated by maintaining the composition at 4°C, room temperature (25°C), or 45°C and observing it visually to confirm whether the composition was layered within 48 hours after stirring. If the tested composition was not layered within 48 hours after stirring at all three temperatures (4°C, room temperature (25°C), and 45°C), it was evaluated as stable; otherwise, it was evaluated as unstable.

[0101] The stickiness of each composition prepared above was evaluated as follows.

[0102] Five skincare formulation scientists applied 50 μl of the composition under test to a 6.3 cm x 6.3 cm area of ​​skin on their arm using two clean fingers. They then scored the stickiness during and after application according to the following criteria and averaged the results: 1 = Non-sticky, 2 = Just the right amount of stickiness for a facial cream. 3 = It is very sticky.

[0103] The spreadability during application was scored and averaged according to the following criteria: 1 = It is very easy to extend. 2 = Not difficult to extend, but not extremely easy. 3 = Difficult to extend.

[0104] In addition, the appearance of each obtained composition was observed with the naked eye.

[0105] The viscosity, stability, stickiness, spreadability, and appearance of compositions using comparative formulations and the formulation of the present invention are listed in Table 3.

[0106] [Table 3]

[0107] The compositions of formulations 1 to 3 of the present invention have a smooth and fine texture as a cream and exhibit good spreadability. The compositions of formulations 1 to 3 of the present invention can provide an anti-aging effect to the skin without feeling sticky. Furthermore, the compositions of formulations 1 to 3 of the present invention are stable at 4°C, room temperature (25°C), and 45°C.

Claims

1. A composition for caring for keratin substances, in the form of an oil-in-water cream, wherein, with respect to the total mass of the composition, (i) 3% to 10.5% by mass of hydroxypropyltetrahydropyrantriol, (ii) 0.3% to 3% by mass of at least one water-soluble or water-dispersible copolymer derived from 2-acrylamidomethylpropanesulfonic acid and a nonionic water-soluble comonomer. (iii) 0.05% to 6% by mass of at least one silicone compound selected from C12-C22 alkyl or alkoxydimethicone, C6-C10 alkyl or alkoxylmethicone, or mixtures thereof, and (iv) 0.5% to 20% by mass of ethanol A composition containing the following:

2. The composition according to claim 1, wherein hydroxypropyltetrahydropyrantriol is present in an amount ranging from 3% by mass to 8.75% by mass, based on the total mass of the composition.

3. The nonionic water-soluble comonomer of the water-soluble or water-dispersible copolymer is - (meth)acrylamide, - N-vinylacetamide and N-methyl-N-vinylacetamide, - N-vinylformamide and N-methyl-N-vinylformamide, - Maleic anhydride, - Vinylamine, - N-vinyl lactam containing a cyclic alkyl group with 4 to 9 carbon atoms, - Formula CH 2 =Vinyl alcohol of CHOH, - Water-soluble vinyl monomer of the following formula (III): 【Chemistry 1】 [In the formula, - R 15 H, -CH 3 , -C 2 H 5 and -C 3 H 7 Selected from, - X 2 teeth, -OR 16 (where R 16 is a linear or branched, saturated or unsaturated hydrocarbon group containing 1 to 6 carbons, optionally substituted with a halogen atom), a hydroxyl group (-OH), or an ether) A composition according to claim 1 or 2, selected from the following.

4. The composition according to claim 3, wherein the water-soluble or water-dispersible copolymer is selected from copolymers of 2-acrylamidomethylpropanesulfonic acid and vinylpyrrolidone or vinylformamide, which are partially or completely neutralized or unneutralized with an inorganic base selected from ammonia, sodium hydroxide, and potassium hydroxide.

5. The composition according to any one of claims 1 to 4, wherein the water-soluble or water-dispersible copolymer is present in an amount ranging from 0.5% by mass to 2% by mass with respect to the total mass of the composition.

6. The composition according to any one of claims 1 to 5, wherein the silicone compound is selected from C16-C18 alkyl dimethicone, C6-C10 alkyl methicone, and mixtures thereof.

7. The composition according to any one of claims 1 to 6, wherein the silicone compound is present in an amount ranging from 0.5% by mass to 5% by mass relative to the total mass of the composition.

8. The composition according to any one of claims 1 to 7, wherein the aqueous phase of the composition comprises water, ethanol, butylene glycol, and glycerin.

9. The composition according to any one of claims 1 to 8, wherein ethanol is present in an amount ranging from 1% by mass to 15% by mass relative to the total mass of the composition.

10. With respect to the total mass of the composition, (i) 3.15% to 4.2% by mass of hydroxypropyltetrahydropyrantriol, (ii) 1% to 1.5% by mass of an inorganic base selected from ammonia, sodium hydroxide, and potassium hydroxide, which is partially or completely neutralized or not neutralized, 2-acrylamidomethylpropanesulfonic acid and at least one water-soluble or water-dispersible copolymer of vinylpyrrolidone or vinylformamide, (iii) 2% to 4% by mass of at least one silicone compound selected from stearyl dimethicone, cetyl dimethicone, and caprylyl methicone, and mixtures thereof, (iv) 2% to 5% by mass of ethanol The composition according to claim 1, comprising:

11. A non-therapeutic method for caring for a keratinous substance, comprising the step of applying a composition according to any one of claims 1 to 10 to the keratinous substance.

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