Skin cosmetic composition

Abstract

To provide a skin cosmetic composition that exhibits excellent anti-inflammatory effects on the skin by increasing the production of IL-1ra, which prevents inflammatory signaling to cells. [Solution] (A) Curcumin and, (B) Contains baicalin, The skin cosmetic composition is characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less.

Description

[Technical Field]

[0001] This invention relates to a skin cosmetic composition. [Background technology]

[0002] Individuals with sensitive skin have a highly hypersensitive skin condition and have been reported to experience recurrent mild inflammation due to physical or chemical stimuli on a daily basis (see Non-Patent Literature 1). Conventionally, skin cosmetic compositions for individuals with sensitive skin have been sought after for their ability to improve sensitive skin symptoms such as dryness and itching, and skin cosmetic compositions containing active ingredients with moisturizing and anti-inflammatory effects, as well as plant extracts, have been provided.

[0003] Conventional skin cosmetic compositions include, for example, skin cosmetic compositions containing curcumin, taurine, and acetyl hexapeptide-8 (see, for example, Patent Document 1), and skin cosmetic compositions containing scutellaria baicalensis extract, which is an IL-8 expression inhibitor (see, for example, Patent Document 2). However, conventional skin cosmetic compositions, including those described in Patent Documents 1 and 2, had room for improvement in terms of their anti-inflammatory effect on the skin.

[0004] Therefore, no skin cosmetic composition with superior anti-inflammatory effects on the skin has yet been provided, and its rapid development is strongly desired. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Japanese Patent Publication No. 2024-098962 [Patent Document 2] Japanese Patent Publication No. 2023-133599 [Non-patent literature]

[0006] [Non-Patent Document 1] J.Cos.Sci.Soc.,45(2):97-105(2021) [Overview of the project] [Problems that the invention aims to solve]

[0007] The present invention aims to solve the aforementioned problems of the conventional approach and achieve the following objective: to provide a skin cosmetic composition that exhibits excellent skin inflammation suppression effects by increasing the production of IL-1ra, which prevents inflammatory signaling to cells. [Means for solving the problem]

[0008] As a result of diligent research to achieve the above objective, the present inventors have found that the skin cosmetic composition of the present invention contains (A) curcumin and (B) baicalin, and the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less, thereby providing a skin cosmetic composition that has an excellent effect in suppressing skin inflammation by increasing the production of IL-1ra, which prevents inflammatory signaling to cells.

[0009] The present invention is based on the aforementioned findings by the inventors, and the means for solving the aforementioned problems are as follows. <1> (A) Curcumin and, (B) Contains baicalin, The skin cosmetic composition is characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less. <2> The content of component (A) is 0.000002% by mass or more and 0.00012% by mass or less, based on the total amount of the skin cosmetic composition. The content of component (B) is 0.000001% by mass or more and 0.00008% by mass or less, based on the total amount of the skin cosmetic composition. <1> This is a skin cosmetic composition as described above. <3> The skin cosmetic composition according to <1> or <2>, wherein the mass ratio [(B) / (A)] of the content of the component (B) to the content of the component (A) is 0.1 or more and 1 or less.

Advantages of the Invention

[0010] According to the present invention, it is possible to solve the above-mentioned various problems and achieve the above object, and to provide a skin cosmetic composition excellent in the effect of suppressing skin inflammation by increasing the production of IL-1ra that prevents inflammatory signal transduction to cells.

Modes for Carrying Out the Invention

[0011] (Skin Cosmetic Composition) The skin cosmetic composition according to the present invention contains (A) curcumin and (B) baicalin, and may contain other components as necessary.

[0012] In this specification, “(A) curcumin” may be referred to as “component (A)”, and “(B) baicalin” may be referred to as “component (B)”.

[0013] <(A) Curcumin> The component (A) is contained in order to impart an effect of promoting the production of IL-1ra (interleukin-1 receptor antagonist) to the skin cosmetic composition. IL-1ra is a protein that binds to the interleukin-1 receptor on the cell surface and has an effect of preventing inflammatory signal transduction to cells.

[0014] For the component (A), those synthesized appropriately may be used, or commercially available products may be used. Examples of commercially available products of the component (A) include, for example, curcumin (Wako special grade, manufactured by Fujifilm Wako Pure Chemical Corporation) under the trade name, and as extracts, turmeric extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.), Falcolec turmeric B (manufactured by Ichimaru Pharcos Co., Ltd.), tropical turmeric extract (manufactured by NOF Corporation), and turmeric extract (manufactured by Yamada Pharmaceutical Co., Ltd.).

[0015] From the perspective of the promoting effect on the production of IL-1ra, the content of the component (A) is preferably 0.000002% by mass or more and 0.00036% by mass or less, more preferably 0.000002% by mass or more and 0.00012% by mass or less, based on the total amount of the skin cosmetic composition.

[0016] When the content of the component (A) is 0.000002% by mass or more based on the total amount of the skin cosmetic composition, the promoting effect on the production of IL-1ra is good.

[0017] When the content of the component (A) is 0.00036% by mass or less based on the total amount of the skin cosmetic composition, the promoting effect on the production of IL-1ra is good.

[0018] <(B) Baicalin> The component (B) is contained in the skin cosmetic composition to impart a promoting effect on the production of IL-1ra.

[0019] For the component (B), those synthesized as appropriate may be used, or commercially available products may be used. Examples of commercially available products of the component (B) include, for example, by trade name, Ougon Liquid B(N), Ougon Liquid SE, Ougon Extract Powder (above, manufactured by Ichimaru Pharcos Co., Ltd.), Ougon Extract BG-50 (manufactured by Koei Kogyo Co., Ltd.), Ougon Extract-J, Brandtage <White>, Brandtage <White> EX (above, manufactured by Maruzen Pharmaceutical Co., Ltd.), Ougon Extract BG (manufactured by Yamada Pharmaceutical Co., Ltd.), and the like.

[0020] From the perspective of the promoting effect on the production of IL-1ra, the content of the component (B) is preferably 0.000001% by mass or more and 0.00018% by mass or less, more preferably 0.000001% by mass or more and 0.00008% by mass or less, based on the total amount of the skin cosmetic composition.

[0021] When the content of the component (B) is 0.000001% by mass or more based on the total amount of the skin cosmetic composition, the promoting effect on the production of IL-1ra is good.

[0022] When the content of component (B) is 0.00018% by mass or less relative to the total amount of the skin cosmetic composition, the effect of promoting IL-1ra production is good.

[0023] [Mass ratio (B) / (A)] In the skin cosmetic composition according to the present invention, the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less, preferably 0.1 or more and 1 or less.

[0024] When the mass ratio [(B) / (A)] is 0.05 or higher, the effect of promoting IL-1ra production is good.

[0025] When the mass ratio [(B) / (A)] is 5 or less, the effect of promoting IL-1ra production is good.

[0026] <Other ingredients> The skin cosmetic composition according to the present invention may contain other components in addition to the components (A) to (B) described above, as long as they do not impair the effects of the present invention.

[0027] The aforementioned other components are not particularly limited and can be appropriately selected depending on the purpose. Examples include surfactants, water-soluble polymers, oils, silicones, alcohols such as lower or higher alcohols, lanolin derivatives, protein derivatives, drugs such as vitamins, disinfectants, preservatives, pH adjusters such as potassium hydroxide, citric acid, and hydrochloric acid, antioxidants, chelating agents, ultraviolet absorbers, plant and animal extracts or their derivatives, chelating agents such as EDTA, dyes, fragrances, pigments, inorganic powders, clay minerals, and water-insoluble polymer compound powders such as nylon and polyethylene. These can be used individually or in combination of two or more.

[0028] The content of the other components mentioned above is not particularly limited, as long as it does not impair the effects of the present invention, and can be set as appropriate depending on the purpose.

[0029] The other components mentioned above may be synthesized as appropriate, or commercially available products may be used.

[0030] <<Surfactants>> Examples of the aforementioned surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

[0031] <<<Anionic surfactants>>> The anionic surfactant is not particularly limited and can be appropriately selected depending on the purpose, but higher fatty acid salts, polyoxyethylene alkyl ether sulfates, ether carboxylic acids or their salts, and amino acid-type surfactants are preferred, with higher fatty acid salts being more preferred. These can be used individually or in combination of two or more.

[0032] -High-grade fatty acid salts- The aforementioned higher fatty acid salts are not particularly limited and can be appropriately selected depending on the purpose. Examples include laurate, myristic acid, palmitate, and stearate. Among these, laurate, myristic acid, and palmitate are preferred.

[0033] The counterions in the higher fatty acid salts of the anionic surfactant are not particularly limited and can be appropriately selected depending on the purpose. Examples include alkali metal ions, ammonium ions, alkanolamines, and basic amino acids.

[0034] Examples of such alkali metal ions include sodium ions and potassium ions.

[0035] Examples of such alkanolamines include monoethanolamine, diethanolamine, and triethanolamine.

[0036] Examples of such basic amino acids include lysine and arginine.

[0037] The aforementioned higher fatty acid salt can be formulated as a higher fatty acid salt, or it may be formed by adding the higher fatty acid and the salt that acts as the counterion separately to the mixing tank and subjecting them to a neutralization reaction.

[0038] The higher fatty acids used in the preparation of the higher fatty acid salts may be synthesized as appropriate, or commercially available products may be used. Examples of commercially available higher fatty acids include NAA(registered trademark)-122 (lauric acid, manufactured by NOF Corporation), NAA-142 (myristic acid, manufactured by NOF Corporation), NAA-160 (palmitic acid, manufactured by NOF Corporation), and NAA-180 (stearic acid, manufactured by NOF Corporation), among others.

[0039] The aforementioned higher fatty acid salt may be synthesized as appropriate, or a commercially available product may be used. Examples of commercially available higher fatty acid salts include, by trade name, NIKKOL Potassium Laurate LK-120 (potassium laurate, manufactured by Nikko Chemicals Co., Ltd.), NIKKOL Potassium Myristate MK-140 (potassium myristate, manufactured by Nikko Chemicals Co., Ltd.), and Thai Soap MNK-40 (liquid containing potassium coconut oil fatty acid and potassium myristate, manufactured by Nikko Chemicals Co., Ltd.).

[0040] -Polyoxyethylene (POE) alkyl ether sulfate- The polyoxyethylene alkyl ether sulfate is not particularly limited and can be appropriately selected depending on the purpose. For example, a compound represented by the following general formula (A1) can be used. Polyoxyethylene alkyl ether sulfates may be used individually or in combination of two or more types.

[0041] [ka]

[0042] In the above general formula (A1), R 1represents an alkyl group, and the number of carbon atoms in the alkyl group portion is preferably 10 to 14.

[0043] In the general formula (A1) above, n represents the average number of moles of ethylene oxide (EO) added, and the average number of moles of ethylene oxide added is preferably 1 to 5.

[0044] In the general formula (A1) above, X represents an alkali metal or ammonium. There are no particular restrictions on the alkali metal, and it can be appropriately selected depending on the purpose; for example, sodium, potassium, etc.

[0045] Specific examples of the aforementioned polyoxyethylene alkyl ether sulfates include polyoxyethylene(1) lauryl ether sodium sulfate, polyoxyethylene(2) lauryl ether sodium sulfate (also known as POE(2) laureth sulfate sodium), polyoxyethylene(3) lauryl ether sodium sulfate (also known as POE(3) laureth sulfate sodium), polyoxyethylene(4) lauryl ether sodium sulfate, polyoxyethylene(5) lauryl ether sodium sulfate, polyoxyethylene(3) alkyl(C12,13) ​​ether sodium sulfate, polyoxyethylene(2) lauryl ether ammonium sulfate, and polyoxyethylene(3) lauryl ether ammonium sulfate. The numbers in parentheses above represent the average number of moles (n) of ethylene oxide (EO) added.

[0046] -Ether carboxylic acid or its salt- The ether carboxylic acid or its salt is not particularly limited and can be appropriately selected depending on the purpose. Examples include compounds represented by the following general formulas (A2) or (A3). Furthermore, ether carboxylic acids or their salts may be used individually or in combination of two or more.

[0047] [ka]

[0048] [ka]

[0049] In the general formulas (A2) and (A3), R 2 R represents a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, or a phenyl group substituted with a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms. 2 The carbon number of the portion is preferably 10 to 14.

[0050] In the general formula (A2), R 3 These may be the same or different, and represent an alkylene group having 2 to 4 carbon atoms, with 2 carbon atoms being preferred.

[0051] In the general formula (A2), o represents the average number of moles of alkylene oxide added, ranging from 1 to 20. The average number of moles of alkylene oxide added is preferably 1 to 5.

[0052] In the general formulas (A2) and (A3), M 1 This represents a hydrogen atom, alkali metal, alkaline earth metal, ammonium, or basic amino acid.

[0053] Among these, polyoxyalkylene alkyl ether carboxylic acid or a salt thereof is preferred. Polyoxyethylene (POE) alkyl ether acetate is preferred as the polyoxyalkylene alkyl ether carboxylic acid or salt thereof.

[0054] The aforementioned ether carboxylate may be synthesized as appropriate, or a commercially available product may be used. Examples of commercially available ether carboxylates include, by trade name, Energikol EC-30 (manufactured by Lion Specialty Chemicals Co., Ltd., sodium polyoxyethylene (3) lauryl ether acetate), Viewlight LCA-25F (sodium polyoxyethylene (3) lauryl ether acetate), Viewlight LCA-30D (sodium polyoxyethylene (3) lauryl ether acetate), Viewlight LCA-H (polyoxyethylene (4) lauryl ether acetate), Viewlight LCA-25NH (laureth-4 carboxylic acid), Viewlight SHAA (sodium lauryl glycol carboxylate), Viewlight LCA (sodium polyoxyethylene (3) lauryl ether acetate) (all manufactured by Sanyo Chemical Industries, Ltd.), Kao Akipo RLM-45NV (sodium polyoxyethylene (4.5) lauryl ether acetate), and Kao Akipo RLM-100NV (sodium polyoxyethylene (10) lauryl ether acetate) (all manufactured by Kao Corporation). The numbers in parentheses above represent the average number of added moles (o) of alkylene oxide.

[0055] - Amino acid-type surfactants - The aforementioned amino acid-type surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include compounds represented by the following general formula (A4).

[0056] [ka]

[0057] In the above general formula (A4), R 4 This refers to a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms, or a phenyl group substituted with a linear or branched alkyl or alkenyl group having 5 to 23 carbon atoms.

[0058] In the above general formula (A4), R 5represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.

[0059] In the general formula (A4), R 6 and R 7 may be the same or different, and each represents a hydrogen atom or -(CH2)q-COOM 3 as defined below.

[0060] In the general formula (A4), p and q may be the same or different, and each represents an integer from 0 to 20.

[0061] In the general formula (A4), M 2 and M 3 may be the same or different, and each represents a hydrogen atom, an alkali metal, an alkaline earth metal, an alkanolamine, ammonium, or a basic amino acid.

[0062] Specific examples of the amino acid type surfactant include sodium lauroyl methyl-β-alanine, sodium coconut fatty acid methylalanine, N-lauroyl-N-methyl-β-alanine triethanolamine, sodium lauroyl sarcosine, sodium N-lauroyl-L-glutamate, and the like. Among these, sodium lauroyl methyl-β-alanine and sodium coconut fatty acid methylalanine are preferred. These may be used alone or in combination of two or more.

[0063] The aforementioned amino acid-type surfactant may be one that has been synthesized as appropriate, or a commercially available product may be used. Examples of such commercially available products include, by product name, NIKKOL Alaninate LN-30 (sodium lauroyl methyl-β-alanine), NIKKOL Sarcosinate LN (sodium lauroyl sarcosinate) (both manufactured by Nikko Chemicals Co., Ltd.), Alanone ACE (sodium coconut oil fatty acid methylalanine), Alanone ALE (sodium lauroyl methyl-β-alanine), Soypon® SLP (sodium lauroyl sarcosinate) (both manufactured by Kawaken Fine Chemicals Co., Ltd.), Energicol L-30AN (sodium lauroyl methyl-β-alanine, manufactured by Lion Specialty Chemicals Co., Ltd.), Softilt AT-L (N-lauroyl-N-methyl-β-alanine triethanolamine, manufactured by NOF Corporation), and Amisoft® LS-11 (sodium N-lauroyl-L-glutamate, manufactured by Ajinomoto Co., Inc.).

[0064] There are no particular restrictions on the content of the anionic surfactant, and it can be appropriately selected depending on the purpose, but it is preferably 1.0% by mass or more and 25% by mass or less, and more preferably 3% by mass or more and 7% by mass or less, based on the total amount of the skin cosmetic composition.

[0065] <<<Cational surfactants>>> The cationic surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include alkylamine salts, fatty acid amideamine salts, alkyltrimethylammonium salts, dialkyldimethylammonium salts, and alkyldimethylbenzylammonium salts.

[0066] <<<Amphoteric surfactants>>> The aforementioned amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include betaine-type amphoteric surfactants and amino acid-type amphoteric surfactants. Among these, betaine-type amphoteric surfactants are preferred. These can be used individually or in combination of two or more.

[0067] The betaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include alkylbetaine-type amphoteric surfactants, amidebetaine-type amphoteric surfactants, sulfobetaine-type amphoteric surfactants, and imidazoline-type amphoteric surfactants. These may be used individually or in combination of two or more types.

[0068] The alkylbetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include lauryldimethylaminoacetic acid betaine, coconut oil alkyl betaine, and stearyldimethylaminoacetic acid betaine. These can be used individually or in combination of two or more.

[0069] The aforementioned amidobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, and palm kernel oil fatty acid amidopropyl betaine. These can be used individually or in combination of two or more.

[0070] The sulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include lauryl hydroxysulfobetaine, lauramidopropyl hydroxysultaine, coconut oil fatty acid dimethylamino hydroxysulfobetaine, and lauryl dimethylamino hydroxysulfobetaine. These can be used individually or in combination of two or more.

[0071] The imidazoline-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include sodium N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine, sodium N-coconut oil fatty acid acyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. These can be used individually or in combination of two or more.

[0072] Among these, amidobetaine-type amphoteric surfactants and alkylbetaine-type amphoteric surfactants are preferred, lauramidopropyl betaine and lauryldimethylaminoacetic acid betaine are more preferred, and lauramidopropyl betaine is even more preferred.

[0073] There are no particular restrictions on the content of the amphoteric surfactant, and it can be appropriately selected depending on the purpose, but it is preferably 2% by mass or more and 15% by mass or less, more preferably 3% by mass or more and 10% by mass or less, and even more preferably 4% by mass or more and 10% by mass or less, based on the total amount of the skin cosmetic composition.

[0074] The aforementioned amphoteric surfactant may be synthesized as appropriate, or a commercially available product may be used. Examples of commercially available amphoteric surfactants include, for example, alkyl betaine-type amphoteric surfactants such as Amhitol 24B (lauryldimethylaminoacetic acid betaine, manufactured by Kao Corporation), Nissan Anon® BL (lauryldimethylaminoacetic acid betaine, manufactured by NOF Corporation), NIKKOL AM-301 (lauryldimethylaminoacetic acid betaine, manufactured by Nikko Chemicals Co., Ltd.), Amogen® S (lauryldimethylaminoacetic acid betaine, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), and Amogen SH (lauryldimethylaminoacetic acid betaine, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.); amide betaine-type amphoteric surfactants such as Enerdicol L-30B (lauric acid amidopropyl betaine, manufactured by Lion Specialty Chemicals Corporation), Nissan Anon BDF-SF (coconut oil fatty acid amidopropyl betaine, manufactured by NOF Corporation), and Obazolin CAG-30 (coconut oil fatty acid amidopropyl betaine, manufactured by Toho Chemical Industry Co., Ltd.); and Amhitol Examples include sulfobetaine-type amphoteric surfactants such as 20HD (lauryl hydroxysulfobetaine, manufactured by Kao Corporation) and softazoline LSB (lauramidopropyl hydroxysultaine, manufactured by Kawaken Fine Chemicals Co., Ltd.); and imidazoline-type amphoteric surfactants such as NIKKOL AM-101 (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, manufactured by Nikko Chemicals Co., Ltd.) and Nissan Anon GLM-R-LV (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, manufactured by NOF Corporation).

[0075] In addition to those mentioned above, alkylamine oxide compounds can also be used as the aforementioned amphoteric surfactant.

[0076] The alkylamine oxide compound is not particularly limited and can be appropriately selected depending on the purpose. Examples include alkyldimethylamine oxide and dihydroxyethyl laurylamine oxide.

[0077] Examples of the alkyldimethylamine oxide include lauryldimethylamine oxide, myristyldimethylamine oxide, coconut alkyldimethylamine oxide, and oleyldimethylamine oxide. Among these, lauryldimethylamine oxide is preferred. These may be used individually or in combination of two or more types.

[0078] The content of the alkylamine oxide compound is preferably 1% by mass or more and 4% by mass or less, and more preferably 1% by mass or more and 3% by mass or less, based on the total amount of the skin cosmetic composition.

[0079] <<<Nonionic surfactant>>> The nonionic surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples include polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, sorbitan fatty acid esters, polyglycerin fatty acid esters, sucrose fatty acid esters, alkyl polyglycosides, and polyoxyethylene polyoxypropylene glycol.

[0080] <<Oil content>> The aforementioned oils are not particularly limited and can be appropriately selected according to the purpose. Examples include vegetable oils and fats such as castor oil, olive oil, cocoa oil, hydrogenated palm oil, camellia oil, coconut oil, wood wax, jojoba oil, grapeseed oil, and avocado oil, and their ester compounds; animal oils and fats such as mink oil and egg yolk oil; waxes such as beeswax, whale wax, lanolin, hydrogenated lanolin, carnauba wax, and candelilla wax; hydrocarbons such as liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, and petrolatum; natural and synthetic fatty acids such as oleic acid, isostearic acid, and behenic acid; and esters such as glycerol tri-2-ethylhexanoate, 2-ethylhexyl stearate, butyl stearate, isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate. These can be used individually or in combination of two or more.

[0081] There are no particular restrictions on the oil content, and it can be appropriately selected depending on the purpose, but it is preferable that it be 0.1% by mass or more and 3% by mass or less of the total amount of the skin cosmetic composition.

[0082] <<Alcoholic beverages>> There are no particular restrictions on the alcohols mentioned above, and they can be appropriately selected depending on the purpose. Examples include natural and synthetic higher alcohols such as cetyl alcohol, oleyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, and lauryl alcohol. These can be used individually or in combination of two or more.

[0083] <<Moisturizer>> There are no particular restrictions on the humectant, and it can be appropriately selected depending on the purpose. Examples include isoprene glycol, 1,2-pentanediol, diethylene glycol, diethylene glycol monoalkyl ether, polypropylene glycol, polypropylene glycol, hydrogenated castor oil (30 E.O.), diglycerin, triglycerin, and polyglycerin. These can be used individually or in combination of two or more.

[0084] There are no particular restrictions on the amount of the humectant, and it can be appropriately selected depending on the purpose, but it is preferably 0.1% by mass or more and 10% by mass or less based on the total amount of the skin cosmetic composition.

[0085] <<Preservatives>> There are no particular restrictions on the preservatives mentioned above, and they can be appropriately selected depending on the purpose. Examples include benzoates, sorbates, dehydroacetates, parahydroxybenzoates, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, benzalkonium chloride, hinokitiol, resorcinol, methylchloroisothiazolinone / methylisothiazolinone solution (product name: Kayson CG, manufactured by Rohm & Haas Japan), salicylic acid, pentanediol, phenoxyethanol, and ethanol. These can be used individually or in combination of two or more.

[0086] There are no particular restrictions on the amount of the preservative, and it can be appropriately selected depending on the purpose, but it is preferable that it be 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cosmetic composition.

[0087] <<Antioxidant>> The aforementioned antioxidant is not particularly limited and can be appropriately selected depending on the purpose. Examples include dibutylhydroxytoluene, butylhydroxyanisole, and ascorbic acid. These can be used individually or in combination of two or more.

[0088] The content of the antioxidant is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cosmetic composition.

[0089] <<Chelating agent>> The chelating agent is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include disodium edetate, ethylenediaminetetraacetate, hexametaphosphate, gluconic acid, and the like. These may be used alone or in combination of two or more.

[0090] The content of the chelating agent is not particularly limited and can be appropriately selected according to the purpose. However, it is preferably 0.1% by mass or more and 1% by mass or less based on the total amount of the skin cosmetic composition.

[0091] <<pH adjuster>> The pH adjuster is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include sodium hydroxide, potassium hydroxide, citric acid, succinic acid, triethanolamine, aqueous ammonia, triisopropanolamine, phosphoric acid, glycolic acid, and the like. These may be used alone or in combination of two or more.

[0092] <<Ultraviolet absorber or scattering agent>> The ultraviolet absorber or the scattering agent is not particularly limited and can be appropriately selected according to the purpose. Examples thereof include 2-hydroxy-4-methoxybenzophenone, octyldimethyl para-aminobenzoate, ethylhexyl paramethoxysalicylate, titanium oxide, kaolin, talc, and the like. These may be used alone or in combination of two or more.

[0093] <<Vitamins>> There are no particular restrictions on the vitamins mentioned above, and they can be appropriately selected according to the purpose. Examples include vitamin A, B vitamins, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, α-lipoic acid, orotic acid, and their derivatives. These can be used individually or in combination of two or more.

[0094] There are no particular restrictions on the content of the vitamins, and they can be appropriately selected depending on the purpose, but it is preferable that the content is 0.001% by mass or more and 0.5% by mass or less of the total amount of the skin cosmetic composition.

[0095] <<Amino Acids>> The aforementioned amino acids are not particularly limited and can be appropriately selected depending on the purpose. Examples include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine, and their derivatives. These can be used individually or in combination of two or more.

[0096] There are no particular restrictions on the content of the aforementioned amino acids, and they can be appropriately selected depending on the purpose, but it is preferable that the content is 0.001% by mass or more and 0.5% by mass or less of the total amount of the skin cosmetic composition.

[0097] <<Fragrance>> There are no particular restrictions on the aforementioned fragrances, and they can be appropriately selected according to the purpose. For example, fragrance compositions A to D described in paragraphs

[0065] to

[0071] of Japanese Patent Publication No. 2002-128658, fragrance compositions A to E described in paragraphs

[0076] to

[0088] of Japanese Patent Publication No. 2003-73249, or blended fragrance compositions 1 to 4 described in paragraphs

[0016] to

[0023] of Japanese Patent Publication No. 2020-132680 can be used.

[0098] [pH] The pH (at 25°C) of the skin cosmetic composition according to the present invention is not particularly limited and can be appropriately selected depending on the purpose, but a pH of 3.0 or higher and 10.0 or lower is preferred.

[0099] There are no particular restrictions on the method for measuring the pH of a skin cosmetic composition, and it can be appropriately selected depending on the purpose. For example, it can be measured using a glass electrode color hydrogen ion concentration indicator HM-30R (manufactured by Toa DKK Co., Ltd., electrode type GST-5721).

[0100] [viscosity] The viscosity (at 25°C) of the skin cosmetic composition according to the present invention is not particularly limited and can be appropriately selected depending on the purpose, but it is preferably 0.01 Ps·s or more and 40 Pa·s or less.

[0101] There are no particular restrictions on the method for measuring the viscosity of a skin cosmetic composition, and it can be appropriately selected depending on the purpose. For example, a B-type viscometer (manufactured by Tokyo Keiki Co., Ltd.) can be used to measure the viscosity after 1 minute at a sample temperature of 25°C, with a rotation speed of 6 rpm to 60 rpm, using any of rotors No. 1 to No. 4.

[0102] <Method for producing skin cosmetic compositions> There are no particular limitations on the method for producing the aforementioned skin cosmetic composition, and it can be appropriately selected depending on the purpose. For example, it can be prepared by mixing component (A), component (B), and the other components.

[0103] There are no particular limitations on the apparatus for preparing the aforementioned skin cosmetic composition, and an appropriate apparatus can be selected depending on the purpose. For example, an agitator equipped with multiple stirring blades (propellers, turbines, dispersers, etc.) capable of shearing and overall mixing can be used.

[0104] [Application] There are no particular restrictions on the area or method of application of the aforementioned skin cosmetic composition; it can be appropriately selected according to the purpose. For example, it can be used on the whole body, face, hands, etc., in the usual manner. There are no particular restrictions on the use of the aforementioned skin cosmetic composition, and it can be appropriately selected according to the purpose. Examples include lotions, emulsions, body creams, antiperspirants, deodorants, shampoos, conditioners, treatments, body soaps, and hand soaps. [Examples]

[0105] The present invention will be described in more detail below based on examples, comparative examples, and formulation examples, but the present invention is not limited to these examples. Furthermore, the content of each component described in the examples, comparative examples, and formulation examples is shown in "mass%" and is all a pure content equivalent.

[0106] (Examples 1-5 and Comparative Examples 1-4) Each composition with the composition and content shown in Tables 1 and 2 below was prepared by the following method. Specifically, it was prepared by dissolving component (A) and component (B) in DMSO to the predetermined concentration.

[0107] The "evaluation of IL-1ra production promoting effect" was performed using each of the obtained compositions by the following method. The results are shown in Tables 1 and 2.

[0108] [Evaluation of IL-1ra production-promoting effect] Epidermal keratinocyte line (HaCaT) was used as the cell line, and D-MEM (high glucose) (containing L-glutamine, phenol red, sodium pyruvate, and 1,500 mg / L sodium bicarbonate) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was used as the culture medium. IL-1ra production was measured using the IL-1ra / IL-1F3 Human ELISA Kit and Quantikine. First, set HaCaT to 5.0 × 10 5Cells were seeded in a 24-well plate to a cell / well ratio and cultured until adhesion was confirmed. After adhesion was confirmed, each composition was added to each well and cultured overnight in an incubator (CO2 concentration 5%, 37°C). Subsequently, IL-1ra in the cell supernatant was measured using an ELISA kit. The IL-1ra production increase rate ΔIL-1ra was calculated as {(IL-1ra production in wells with added composition - IL-1ra production in wells with only DMSO added) / IL-1ra production in wells with only DMSO added} × 100. Three samples were used, and their average values ​​were evaluated based on the following evaluation criteria. A score of B or higher was considered acceptable. -Evaluation Criteria- A: ΔIL-1ra is 45% or higher B: ΔIL-1ra is between 30% and 45% C:ΔIL-1ra is less than 30%

[0109] [Table 1]

[0110] [Table 2]

[0111] (Prescription examples 1-3) Skin cosmetic compositions of Formulation Examples 1 to 3 were obtained by mixing the materials and their respective contents as shown in Table 3 below.

[0112] [Table 3]

[0113] Details of each component used in Examples 1-5, Comparative Examples 1-4, and Comparative Examples 1-3 are shown in Table 4 below.

[0114] [Table 4] [Industrial applicability]

[0115] The skin cosmetic composition according to the present invention is excellent in suppressing skin inflammation by increasing the production of IL-1ra, which prevents inflammatory signaling to cells, and can therefore be suitably used in products such as lotions, emulsions, body creams, antiperspirants, deodorants, shampoos, conditioners, treatments, body soaps, and hand soaps.

Claims

1. (A) Curcumin and, (B) Contains baicalin and A skin cosmetic composition characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less.

2. The content of component (A) is 0.000002% by mass or more and 0.00012% by mass or less, based on the total amount of the skin cosmetic composition. The skin cosmetic composition according to claim 1, wherein the content of component (B) is 0.000001% by mass or more and 0.00008% by mass or less, based on the total amount of the skin cosmetic composition.

3. The skin cosmetic composition according to claim 1 or 2, wherein the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.1 or more and 1 or less.

Images