Oral components

Abstract

To provide oral compositions with excellent cooling effect and suppressed bitterness derived from di-long chain cationic surfactants.SOLUTION: An oral composition according to the present invention contains ingredient (A): menthol or a derivative thereof, ingredient (B): a di-long chain cationic surfactant, and ingredient (C): sugar alcohol and / or glycerin, the content of the component (A) being 0.01 to 1.5 mass%, and the content of the component (B) being 0.005 to 1.5 mass%. Preferably, the component (A) is l-menthol. Also preferably, the di-long chain cationic surfactant has 14 to 22 carbon atoms in one chain length.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition.

Background Art

[0002] Conventionally, in the field of cosmetics, cationic surfactants are known to have effects such as improving the stability, detergency, and powder dispersibility of formulated preparations, and are used in emulsion cosmetics and the like (for example, Patent Document 1).

[0003] In recent years, it has been found that when a di-long-chain cationic surfactant is combined with a cooling agent such as menthol and formulated into a cosmetic, an improved cooling effect can be obtained. An oil-in-water emulsion cosmetic in which a di-long-chain cationic surfactant is formulated and the cooling effect and emulsion stability are improved has been proposed (for example, Patent Document 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] By the way, in oral compositions, there is no preparation combining a di-long-chain cationic surfactant and a cooling agent, but it is expected that by combining them, an oral composition excellent in the cooling effect can be obtained. However, in an oral composition combining a di-long-chain cationic surfactant and a cooling agent, although the cooling effect is high, a peculiar bitter taste of the di-long-chain cationic surfactant occurs, and it cannot withstand use as an oral composition.

[0006] Therefore, the present invention aims to provide an oral composition that has excellent cooling effect and suppresses the bitterness derived from di-long-chain cationic surfactants. [Means for solving the problem]

[0007] The oral composition according to the present invention comprises (A) component: menthol or a derivative thereof, (B) Component: Dilong chain cationic surfactant, (C) Ingredients: Sugar alcohol and / or glycerin It contains, The content of component (A) is 0.01 to 1.5% by mass, The content of component (B) is 0.005 to 1.5% by mass. the law of nature, Liquid toothpaste or mouthwash ru. [Effects of the Invention]

[0008] According to the present invention, it is possible to provide an oral composition that has excellent cooling effect and suppresses the bitterness derived from di-long-chain cationic surfactants. [Modes for carrying out the invention]

[0009] Preferred embodiments of the oral composition of the present invention will be described in detail below. In this specification, the oral compositions include toothpastes such as paste toothpastes, moist toothpastes, powder toothpastes, liquid toothpastes, etc., as well as lozenges, tablets, creams, ointments, patches, mouthwashes, and chewing gum. Among these, the oral compositions of the present invention are preferably applied to liquid toothpastes, paste toothpastes, moist toothpastes, or mouthwashes, and more preferably to liquid toothpastes or mouthwashes.

[0010] The oral composition of the present invention comprises (A) component: menthol or a derivative thereof, (B) component: dilong-chain cationic surfactant, and (C) component: sugar alcohol and / or glycerin. It contains [this ingredient]. By including these components, it is possible to provide an oral composition that has excellent cooling effect and suppresses the bitterness derived from di-long-chain cationic surfactants.

[0011] <(A) component> The oral composition of the present invention contains 0.01 to 1.5% by mass of menthol or a derivative thereof as component (A). The inclusion of such component (A) results in a cooling sensation after use of the oral composition. Examples of menthol include d-menthol, l-menthol, and dl-menthol, and among these, l-menthol is preferred. Examples of menthol derivatives include menthyl lactate, l-menthyl glyceryl ether, l-menthyl glucoside, l-menthyl hydroxybutyrate, menthoxypropanediol, and menthoxyfuran. In the oral composition of the present invention, the content of component (A) is 0.01 to 1.5% by mass, but is preferably 0.05 to 1.2% by mass, and more preferably 0.1 to 1.0% by mass. If the content of component (A) is below the lower limit, a sufficient refreshing sensation cannot be obtained. On the other hand, if the content of component (A) exceeds the upper limit, a refreshing sensation can be obtained, but the taste derived from component (A) may affect the taste of the oral composition, and a bitter taste may be perceived.

[0012] <(B) component> The oral composition of the present invention contains 0.005 to 1.5% by mass of a di-long-chain cationic surfactant as component (B). The inclusion of the di-long-chain cationic surfactant enhances the refreshing sensation of component (A). The long-chain cationic surfactant preferably has 14 to 22 carbon atoms in each chain, and more preferably 16 to 20. This can enhance the sensitivity of component (A) in the oral cavity, resulting in a greater feeling of freshness. Examples of di-long-chain cationic surfactants include dibehenyldimethylammonium, dicetostearyldimethylammonium, dimyristyldimethylammonium, dioctadecyldimethylammonium, distearyldimethylammonium, dicocoylethylhydroxyethylmonium, didecyldimethylammonium, dicocoyldimethylammonium, dicocoyldimethylammonium, dicocoyldimethylammonium, dilauryldimethylammonium, dicetyldimethylammonium, dipalmityldimethylammonium, dioleyldimethylammonium, dipalmitoylethylhydroxyethylmonium, dicocoylhydroxyethylmethylmonium, distearylethylhydroxyethylmonium, or salts thereof (halides (chlorides, bromides, etc.) or methosulfates). In particular, it is preferable to use distearyldimethylammonium or a salt thereof, more preferable to use distearyldimethylammonium chloride or distearyldimethylammonium bromide, and even more preferable to use distearyldimethylammonium chloride. This can enhance the sensitivity of component (A) in the oral cavity and provide a greater refreshing sensation. In the oral composition of the present invention, the content of component (B) is 0.005 to 1.5% by mass, but is preferably 0.01 to 1.2% by mass, and more preferably 0.1 to 1.0% by mass. If the content of component (A) is below the lower limit, the effect of improving the refreshing sensation may not be sufficiently obtained. On the other hand, if the content of component (A) exceeds the upper limit, the taste derived from component (B) will affect the taste of the oral composition, and a bitter taste may be perceived.

[0013] <(C) component> The oral composition of the present invention contains a sugar alcohol and / or glycerin as component (C). By including component (C), the bitterness of component (B) can be suppressed. Furthermore, the dispersibility of component (A) in the oral cavity when using the oral composition can be improved, thereby enhancing the refreshing sensation. Examples of sugar alcohols include trehalose, erythritol, pentaerythritol, dipentaerythritol, tripentaerythritol, arabitol, ribitol, xylitol, sorbitol, mannitol, threitol, glycerol, talitol, galactitol, allitol, altitol, dulcitol, iditol, inositol, maltitol, isomaltitol, lactitol, turanitol, etc., and one or more of these can be used in combination. Among these, it is preferable to use one selected from the group consisting of sorbitol, xylitol, erythritol, maltitol, and mannitol.

[0014] In the oral composition of the present invention, the content of component (C) is not particularly limited, but it is preferably 1 to 50% by mass, more preferably 3 to 40% by mass, and even more preferably 5 to 30% by mass. Thereby, while suppressing the influence of component (C) itself on the taste, the bitterness of component (B) can be more efficiently suppressed.

[0015] <Other components> In the oral composition of the present invention, various components may be blended according to its dosage form and the like. For example, in the oral composition of the present invention, an abrasive, a humectant (a humectant other than glycerin and sugar alcohol), a binder, a foaming agent, a sweetener, a preservative, a fragrance component, a medicinal component, etc. can be blended. Examples of abrasives include silica-based abrasives such as silica gel, precipitated silica, pyrogenic silica, hydrous silicic acid, anhydrous silicic acid, zeolite, aluminosilicate, zirconosilicate, calcium hydrogen phosphate for toothpaste such as dicalcium phosphate dihydrate, dicalcium phosphate anhydrate, calcium pyrophosphate, magnesium phosphate tribasic, tricalcium phosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, zirconium silicate, synthetic resin-based abrasives, etc., and one or more of these can be used in combination.

[0016] As wetting agents other than glycerin and sugar alcohols, diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, isopropyl glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, etc. can be mentioned, and one or more of these can be used in combination.

[0017] As solvents, organic solvents such as ethanol, propyl alcohol, isopropyl alcohol, and water can be mentioned. These solvents can be blended alone or in combination of two or more. As binders, alginates and their derivatives such as carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, ammonium alginate, xanthan gum, guar gum, agar, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, etc. can be mentioned, and one or more of these can be used in combination.

[0018] As fragrances, anethole, menthone, cineole, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal, etc. can be mentioned, and one or more of these can be used in combination. These components can be blended alone, or essential oils containing these can also be blended. Also, in addition to the above fragrance components, fragrance components such as aliphatic alcohols and their esters, terpene hydrocarbons, phenol ethers, aldehydes, ketones, lactones, etc., and essential oils can be blended within the range that does not interfere with the effects of the present invention.

[0019] Examples of excipients include sucrose, lactose, starch, glucose, crystalline cellulose, palatinose, trehalose, lactulose, coupling sugar, gum base, gum arabic, gelatin, cetyl methylcellulose, light anhydrous silicic acid, magnesium aluminate, calcium aluminometasilicate, sodium bicarbonate, and calcium phosphate.

[0020] Examples of sweeteners include sodium saccharin, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perillartin. One or more of these can be used in combination.

[0021] Examples of pH adjusting agents include citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphate, lactic acid, tartaric acid, glycerophosphate, acetic acid, nitric acid, or chemically possible salts thereof such as disodium hydrogen phosphate, or sodium hydroxide. These can be used individually or in combination of two or more to ensure the pH of the composition is within an appropriate range.

[0022] Examples of preservatives include para-hydroxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, etc., and one or more of these can be used in combination.

[0023] Examples of emulsifiers include polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, sodium stearoyl lactylate, soybean phospholipids, and alkyltrimethylammonium chloride. Examples of solubilizing agents include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, and sulfated fatty alcohols.

[0024] Examples of foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerin fatty acid esters, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters. One or more of these can be used in combination. Examples of lubricants include magnesium stearate, sucrose fatty acid esters, talc, and hydrogenated oils. Examples of oils other than the essential oils used as antibacterial components and the oils used as fragrances include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, and safflower oil.

[0025] Examples of surfactants include sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosinate, N-acyl glutamate, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, alkyldimethylamine oxide, lauryl ethanolamide, sodium cocoyl sarcosinate, and sodium N-lauroyl methyl taurate solution.

[0026] Furthermore, the oral composition of the present invention may contain additional active ingredients. Examples of such active ingredients include lysozyme chloride, tranexamic acid, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, ascorbic acid, ascorbates, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, decalinium chloride, isopropylmethylphenol, bisabolol, ascorbic acid and / or its derivatives, tocopherol acetate, ε-aminocaproic acid, aluminum hydroxyl allantoin, aluminum lactate, potassium nitrate, dihydrocholesterol, copper chlorophyllin salt, sodium chloride, guaiazulene sulfonate, dextranase, pyridoxine hydrochloride, and others, and one or more of these may be included.

[0027] Furthermore, the oral composition of the present invention may also contain herbal extracts in addition to the above. Examples of herbal extracts include chamomile extract, valerian extract, jujube extract, hop extract, lavender extract, linden extract, quince extract, honeysuckle extract, bamboo grass extract, elm extract, clove extract, ginseng extract, sage extract, soapberry extract, balloon flower extract, rehmannia extract, peony extract, hawthorn extract, angelica extract, tea extract, evergreen oak extract, Phellodendron bark extract, birch extract, ginseng extract, catechu extract, turmeric extract, rosemary extract, etc., and one or more of these can be used in combination.

[0028] The oral composition of the present invention can be manufactured in accordance with conventional methods, and the manufacturing method is not particularly limited. Furthermore, the resulting oral composition can be used by filling it into aluminum tubes, laminate tubes, glass-coated tubes, plastic tubes, plastic bottles, aerosol containers, etc.

[0029] The oral composition of the present invention has been described above, but the present invention is not limited thereto. For example, in addition to the components described above, the oral composition of the present invention may contain any other components having any function. [Examples]

[0030] Next, specific embodiments of the present invention will be described. <Manufacturing of oral compositions> (Examples 1-11, Comparative Examples 1-7) The components shown in Tables 1 and 2 were prepared to the quantities shown in Tables 1 and 2, and an oral composition (liquid toothpaste) was manufactured according to conventional methods.

[0031] <Evaluation Method> (Evaluation of refreshing feeling) Ten subjects were asked to use the oral compositions of each example and comparative example, and to evaluate them according to the following criteria. The average values ​​were then used for evaluation according to the following criteria. • Refreshing feeling (evaluation criteria) 5 points: Very refreshing feeling 4 points: Feels refreshing 3 points: Slightly refreshing feeling 2 points: I hardly feel any cooling sensation. 1 point: Does not feel refreshing.

[0032] • Evaluation of average score ◎: Average score of 4.0 or higher ○: Average score is between 3.0 and 4.0 points. △: Average score is between 2.0 and 3.0 points. ×: Average score is less than 2.0 points

[0033] (Taste evaluation) Ten subjects were asked to use the oral compositions of each example and comparative example, and to evaluate them according to the following criteria. The average values ​​were then used for evaluation according to the following criteria. • Taste (evaluation criteria) 5 points: No bitterness detected. 4 points: I hardly taste any bitterness. 3 points: Slightly bitter taste. 2 points: I can taste bitterness. 1 point: It tastes very bitter.

[0034] • Evaluation of average score ◎: Average score of 4.0 or higher ○: Average score is between 3.0 and 4.0 points. △: Average score is between 2.0 and 3.0 points. ×: Average score is less than 2.0 points These results are shown in Tables 1 and 2.

[0035] [Table 1]

[0036] [Table 2]

[0037] As can be seen from Tables 1 and 2, the oral compositions of the examples exhibited excellent refreshing sensation, suppressed bitterness derived from di-long-chain cationic surfactants, and provided a superior user experience. In contrast, satisfactory results were not obtained in the comparative examples. Furthermore, when formulations containing the same amounts of components (A), (B), and (C) as in the above examples and comparative examples were manufactured for paste toothpaste, moist toothpaste, and mouthwash, and evaluated in the same manner as above, similar results were obtained.

Claims

1. (A) Components: Menthol or its derivatives, (B) Component: Dilong chain cationic surfactant, (C) Ingredients: Sugar alcohol and / or glycerin It contains, The content of component (A) is 0.01 to 1.5% by mass, The content of component (B) is 0.005 to 1.5% by mass, It is a liquid toothpaste or mouthwash. Oral composition.

2. The content of component (B) is 0.1 to 1.5% by mass. The oral composition according to claim 1.

3. The aforementioned component (A) is l-menthol. The oral composition according to claim 1.

4. The aforementioned long-chain cationic surfactant has 14 to 22 carbon atoms in each chain. The oral composition according to claim 1.

5. The aforementioned component (B) is distearyldimethylammonium or a salt thereof. The oral composition according to claim 1.

6. The aforementioned component (B) is distearyldimethylammonium chloride. The oral composition according to claim 5.

7. The sugar alcohol is at least one selected from the group consisting of sorbitol, xylitol, erythritol, maltitol, and mannitol. The oral composition according to claim 1.

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