Biomimetic System Devices

Abstract

This microphysiological system device (1) comprises: a container (2) in which a plurality of functional units (6a-6d) are accommodated in a replaceable manner; and a flow path member (3) that is disposed on the surface side of the container (2) and partitions at least a portion of flow paths (33a, 33b) that allow the plurality of functional units (6a-6d) accommodated in the container (2) to communicate.

Claims

1. A container that houses multiple functional units in an interchangeable manner, A flow channel member is positioned on the front side of the container and partitions at least a portion of the flow channel that connects the multiple functional units housed in the container, Equipped with, The container and the flow channel member are integrated, The plurality of functional units housed in the container include a liquid delivery unit that delivers a fluid stored inside itself to the flow path, and a culture unit having an incubator inside which a culture medium is stored. The flow channel member has a plurality of contact portions that are arranged opposite to the plurality of functional units housed in the container, The contact portion contacts the functional unit from the front side, The aforementioned flow path is a biomimetic system device that opens on the back surface of the contact portion.

2. The biomimetic system device according to claim 1, wherein, when viewed from the front and back directions, the size of the container is the size of a multiwell plate conforming to industrial standards.

3. The aforementioned container is A rectangular bottom wall having a pair of long sides arranged opposite to each other, and a pair of short sides connecting the pair of long sides and arranged opposite to each other, A pair of side wall portions erected on the front side from the pair of aforementioned long sides, A partition wall that connects the pair of side wall sections, extends parallel to the short side section, and divides the space between the pair of side wall sections into multiple storage compartments, It has, The biomimetic system device according to claim 1, wherein the housing is interchangeable with respect to a plurality of the functional units.

4. The biomimetic system device according to claim 1, wherein the flow channel member comprises a plurality of flow channels and a flow control unit that controls the flow rate of fluid flowing through any of the flow channels.

5. A cover member disposed on the front side of the flow channel member and having higher rigidity than the flow channel member, A fastening member for fastening the cover member and the container, Equipped with, The biomimetic system device according to claim 1, wherein the functional unit is fixed with the flow channel member, and then the container and the flow channel member are integrated with the cover member and the fastening member.

6. The cover member has a front-side engaging portion, The container has a rear engaging portion, The biomimetic system device according to claim 5, wherein the fastening member engages with the front engagement portion and the back engagement portion.

7. The container is A rectangular bottom wall having a pair of long sides arranged opposite to each other, and a pair of short sides connecting the pair of long sides and arranged opposite to each other, A pair of side wall portions erected on the front side from the pair of aforementioned long sides, A partition wall that connects the pair of side wall sections, extends parallel to the short side section, and divides the space between the pair of side wall sections into multiple storage compartments, It has, When viewed from the front and back directions, the size of the container is the size of a multiwell plate conforming to industrial standards. The housing is compatible with multiple of the functional units, The flow path member has a flow control unit that divides a plurality of the flow paths inside and controls the flow rate of the fluid flowing through any of the flow paths. The biomimetic system device according to claim 6, wherein the container, the flow channel member, and the cover member are transparent.

8. The container has a bottom wall and a side wall that is erected on the front side from the bottom wall, The biomimetic system device according to claim 1, wherein the side wall portion has an opening that penetrates itself.

9. The container has a bottom wall portion, The biomimetic system device according to claim 1, wherein the bottom wall portion has an opening that penetrates it.

10. The flow channel member has a contact portion, The aforementioned functional unit has an opening, The contact portion has a pressing portion that is pressed into the opening, The biomimetic system device according to claim 1, wherein the indentation portion is made of a material comprising at least one of PDMS and resin.

11. The biomimetic system device according to claim 1, wherein the flow path is used to degas the functional unit.

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