Systems and methods for generating hyperpolarizing materials

The intermolecular nuclear Overhauser effect transfers polarization from a source compound to a target compound, enhancing NMR/MRI sensitivity by up to 1730 times, addressing the limitations of minute nuclear polarization in existing technologies and enabling advanced imaging and spectroscopy applications.

JP7875867B2Active Publication Date: 2026-06-18エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング
Filing Date
2022-01-31
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) technologies face challenges in detecting minute nuclear polarization, leading to limited sensitivity compared to other analytical techniques like mass spectrometry, which can make NMR/MRI applications unrealistically time-consuming or material-intensive.

⚗Method used

The intermolecular nuclear Overhauser effect (NOE) is used to transfer polarization from a polarization source compound to a target compound, enabling nuclear spin polarization enhancement in NMR spectroscopy and MRI applications without requiring cryogenic temperatures or high magnetic fields.

🎯Benefits of technology

This method achieves signal enhancement of up to 1730 times for benchmark molecules, allowing for high-resolution NMR spectra and new applications such as in vivo metabolism imaging and molecular dynamics visualization.

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Abstract

A system and method for increasing the nuclear spin polarization of a target compound are disclosed. According to such a system and method, a first non-thermal equilibrium nuclear spin polarization may be imparted to source atoms of at least one source compound, the source atoms having a nuclear gyromagnetic ratio of at least 12 megahertz per Tesla (MHz / T). A first solution including a source compound and a target compound can be obtained. The at least one source atom can be present in the first solution at a source concentration of at least 0.1 molar (M). A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to at least one target atom of the target compound via a Nuclear Overhauser Effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to at least one target atom.
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