Powder composition and ready-to-use cosmetic

Abstract

To develop a powder composition excellent in storage stability and dispersibility in water in a powder composition for forming a vesicle when dispersed in water and to develop a cosmetic mixed when in use which is excellent in no stickiness in applying a dispersion to the skin when a powder composition and water are mixed when in use.SOLUTION: There is provided a powder composition which comprises the following components (A) and (B) and forms a vesicle when dispersed in water: (A) one or two or more surfactants selected from the group consisting of a phospholipid and a nonionic surfactant and (B) a cellulose nanofiber.

Description

Technical Field

[0001] The present invention relates to a powder composition and a ready-to-use mixed cosmetic.

Background Art

[0002] In recent years, vesicles, which are closed vesicles formed by a surfactant bilayer membrane, have been expected to be applied to drug delivery systems because they exhibit storage properties and permeability by encapsulating drugs, and are widely used in the fields of pharmaceuticals and cosmetics. In the cosmetic field, for the purpose of storing drugs in the stratum corneum, etc., vesicles are mainly applied in a form dispersed in an aqueous medium. However, since vesicles dispersed in an aqueous medium are likely to aggregate and fuse, it is difficult to ensure storage stability, which is a problem. Therefore, many vesicle formulation technologies have been developed aiming at ensuring storage stability.

[0003] As the above technology, for example, in order to obtain stable liposomes in an aqueous medium, a technology of adding an amino acid to the storage solution of liposomes to strengthen the membrane structure and improve the storage stability (see Patent Document 1), or cholesterol per 100 mol of phospholipid is 0.1 to 20 mol, and a technology of improving the storage stability by liposomes obtained from lipids composed of 0.1 to 20 mol of a dibasic acid-bonded glycolipid in which 1 to 2 mol of a dibasic acid having 2 to 7 carbon atoms and 1 to 2 mol of a fatty acid having 6 to 24 carbon atoms are ester-bonded per 1 mol of a monosaccharide or an oligosaccharide having 2 to 5 constituent monosaccharides (see Patent Document 2) has been reported. Further, in order to further improve the storage stability, a cosmetic powder liposome and a cosmetic using liposomes, which are colorless, odorless, have good dispersibility and usability, are proposed by drying and powdering liposomes for cosmetics characterized in that the membrane constituent components of the liposomes contain hydrogenated soybean phospholipid having a phosphatidylcholine content of 90% by weight or more and an iodine value of 0.1 or less, and the average particle size of the liposomes is 100 to 500 nm (see Patent Document 3).

Prior Art Documents

Patent Documents

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2-273539 [Patent Document 2] Japanese Patent Application Publication No. 04-082824 [Patent Document 3] Japanese Patent Publication No. 2006-124378 [Disclosure of the Invention] [Problems that the invention aims to solve]

[0005] However, in the case of the technology described in Patent Document 1, for example, it tends to feel sticky when applied to the skin, and in the case of the technology described in Patent Document 2, aggregation and precipitation tend to occur over time, raising concerns about storage stability. On the other hand, in the case of the technology described in Patent Document 3, in which vesicles are dried and powdered, if sterols or amino acids are used in combination to improve storage stability and solubility, it becomes sticky when applied to the skin, impairing the user experience. Therefore, there is a strong demand for the development of a vesicle formulation that has excellent storage stability, high dispersibility in water during use, and good usability without stickiness when applied to the skin.

[0006] Therefore, the objectives of the present invention are to develop a powder composition that forms vesicles when dispersed in water, which exhibits excellent storage stability and dispersibility in water, and to develop a ready-to-use cosmetic composition that, when mixed with water at the time of use, exhibits excellent non-stickiness when the dispersed material is applied to the skin. [Means for solving the problem]

[0007] In light of the above circumstances, the inventors investigated various combinations of vesicle compositions with excipients such as cholesterol, but were unable to achieve sufficient effectiveness that balanced storage stability and usability. Therefore, they considered that cellulose nanofibers, which are used to stabilize fine particles, might be useful, and investigated the use of cellulose nanofibers to improve the storage stability of vesicle compositions. As a result, they found that the powder composition exhibited excellent storage stability, as well as excellent dispersibility in water and a lack of stickiness when the dispersed material in water was applied to the skin, thus completing the present invention.

[0008] In other words, the present invention relates to a powder composition containing the following components (A) and (B), which forms vesicles when dispersed in water. (A) One or more surfactants selected from the group consisting of phospholipids and nonionic surfactants. (B) Cellulose nanofiber

[0009] The present invention relates to the powder composition described above, wherein the mass ratio of component (B) to component (A) is (B) / (A) = 0.01 to 1.5.

[0010] Furthermore, the present invention relates to the powder composition described above, which contains component (C) inorganic powder.

[0011] The present invention relates to the powder composition described above, wherein component (C) is one or more inorganic powders selected from the group consisting of silica, mica, and synthetic fluorphlogopite.

[0012] Furthermore, the present invention relates to the powder composition described above, which contains one or more selected from the group consisting of component (D) sugars and sugar alcohols.

[0013] The present invention relates to the powder composition described above, characterized in that it substantially does not contain water.

[0014] This invention relates to a ready-to-use cosmetic composition in which the aforementioned powder composition is mixed with water at the time of use.

[0015] This invention relates to a method of use in which the powder composition described above is mixed with water and applied to the skin. [Effects of the Invention]

[0016] The present invention provides a powder composition with excellent storage stability and dispersibility in water, and a ready-to-use cosmetic composition that, when mixed with water at the time of use, exhibits excellent non-stickiness when the dispersed material is applied to the skin. [Best Mode for Carrying Out the Invention]

[0017] The details of the present invention are described below. In this specification, "~" means a range including the values ​​before and after it. In this invention, "average particle diameter" refers to the median diameter D50 value obtained by measurement using an image analysis device (Luzex AP, manufactured by Nireco). In the case of an asymmetric shape, in this invention, the median diameter D50 obtained from the distribution of the largest particle diameter is taken as the average particle diameter.

[0018] In this invention, the powder composition refers to a substance that is in powder form. Here, "powder form" can be any form, such as particulate matter or molded solid powder. The powder composition of this invention can be used in pharmaceuticals, cosmetics, topical skin preparations, and food compositions. The powder composition of this invention exhibits vesicle effects when dispersed in water. Therefore, when used in the aforementioned fields, it is expected to enhance the penetration of active ingredients and continuously provide effects such as moisturizing and whitening.

[0019] Component (A) in the present invention is one or more surfactants selected from the group consisting of phospholipids and nonionic surfactants. The powder composition of the present invention forms vesicles when dispersed in water, and component (A) is used to form vesicles when dispersed in water. Here, vesicle refers to a spherical closed vesicle formed by a surfactant bilayer in water. The one or more surfactants selected from the group consisting of phospholipids and nonionic surfactants used in component (A) of the present invention are not particularly limited, and any substance can be used as long as a vesicle image can be observed by transmission electron microscopy when dispersed in water. The following is known about substances that form vesicles: Cylinder-shaped molecules that have a hydrophobic chain of a certain length and a structure in which the cross-sectional area of ​​the chain and the cross-sectional area of ​​the polar portion are close are known to form vesicles (Teruo Horiuchi et al., Journal of the Japan Oil Chemical Society, Vol. 49, No. 10, 1107-1122, 2000). Observation methods using a transmission electron microscope include, for example, negative staining, freeze-fracture method, and cryo-TEM. Among these, the freeze-fracture method is preferred. In this invention, vesicle images can be observed using a transmission electron microscope (HT7700, manufactured by Hitachi, Ltd.) with the freeze-fracture method.

[0020] Vesicles using phospholipids are called liposomes. Phospholipids are the main components that form the surfactant bilayer of liposome compositions. The phospholipids in the present invention may be natural phospholipids or modified phospholipids. For example, the origin of natural phospholipids is not particularly limited, and examples include soybeans, egg yolks, sunflower seeds, rapeseeds, etc. More specifically, examples include unhydrogenated egg yolk lecithin, unhydrogenated soy lecithin, hydrogenated egg yolk lecithin, hydrogenated soy lecithin, etc. In addition, modified phospholipids include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, lysophosphatidylcholine, phosphatidylglycerol, sphingomyelin, synthetic lecithin, PEG-modified lecithin, etc. Although not limited thereto, one or more of these phospholipids can be used. Among these, soy-derived is preferred, and it is more preferred to use one or more selected from the group consisting of unhydrogenated soy lecithin and hydrogenated soy phospholipids.

[0021] Commercially available products of the phospholipid of component (A) include Resinol S-10E (manufactured by Nikko Chemicals Co., Ltd.), Resinol S-10EZ (manufactured by Nikko Chemicals Co., Ltd.), HSL-70 (manufactured by WM Shii Co., Ltd.), Basis LS-60HR (manufactured by Nisshin Oillio Group Co., Ltd.), Egg Yolk Lecithin PL-100P (manufactured by Kewpie Corporation), Milk Ceramide 1G (manufactured by Yamakawa Trading Co., Ltd.), Milk Ceramide 4G (manufactured by Yamakawa Trading Co., Ltd.), PHOSPHOLIPON 90H (manufactured by Lipoid), PHOSPHOLIPON 90G (manufactured by Lipoid), LIPOID P 75 (manufactured by Lipoid), LIPOID P 100 (manufactured by Lipoid), etc.

[0022] Vesicles using nonionic surfactants are also called niosomes. Examples of the nonionic surfactant in the present invention include sucrose fatty acid esters, polyoxyethylene ethers, polyglycerol fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and the like. More specifically, one or more selected from the group consisting of polyoxyethylene stearyl ether, polyoxyethylene sorbitan stearate, polyoxyethylene sterol ether, and sorbitan monooleate are preferred.

[0023] Examples of commercially available products of the nonionic surfactant of component (A) include NIKKOL BPS-5 (manufactured by Nikko Chemicals Co., Ltd.), Tween61 (manufactured by SIGMA), Span80 (manufactured by WAKO), and the like.

[0024] In the present invention, the content of component (A) is not particularly limited, but is preferably 10% by mass (hereinafter abbreviated as “%”) or more, more preferably 15% or more, and even more preferably 20% or more based on the total amount of the powder composition. Also, 60% or less is preferable, 55% or less is more preferable, and 50% or less is even more preferable. Further, 10 to 60% is preferable, 15 to 55% is more preferable, and 20 to 50% is even more preferable. Within this range, it is more preferable because of better storage stability, dispersibility in water, and non-stickiness when the dispersion is applied to the skin.

[0025] Component (B) cellulose nanofibers in the present invention are those obtained by refining fibrous cellulose or its derivatives to 2 to 500 nm. In the present invention, component (B) is not particularly limited as long as the average fiber diameter is 2 to 500 nm, and the average fiber diameter is preferably 2 to 500 nm, more preferably 2 to 100 nm, and even more preferably 2 to 50 nm. The average fiber diameter is determined as the arithmetic mean value of the measurement values obtained by measuring the fiber diameters and fiber lengths of 20 fibers of cellulose or its derivatives dispersed in water using an electron microscope image.

[0026] The method for micronizing component (B) is not particularly limited, but examples include mechanical crushing using a high-pressure homogenizer or ball mill, chemical crushing using an N-oxyl compound such as 2,2,6,6-tetramethylpiperidine (TEMPO) to oxidize and micronize the cellulose, and biological crushing using an enzyme such as cellulase. Among these, the chemical crushing method is preferred because the carboxyl groups produced when the hydroxyl groups of cellulose are oxidized during the oxidation reaction contribute to improved impact resistance. The origin of natural cellulose is not particularly limited, and examples include those biosynthesized by plants, animals, and microorganisms.

[0027] Examples of cellulose derivatives include TEMPO-oxidized cellulose, carboxymethylated cellulose, phosphate-esterified cellulose, phosphite-esterified cellulose, sulfonated cellulose, and sulfate-esterified cellulose.

[0028] In the present invention, TEMPO-oxidized cellulose and carboxymethylated cellulose are preferred from the viewpoint of safety for the skin and in vivo, and TEMPO-oxidized cellulose is more preferred from the viewpoint of storage stability and dispersibility in water.

[0029] In component (B), commercially available products of TEMPO-oxidized cellulose include Leolista C-2SP (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) and Selenpia TC-01A (manufactured by Oji Paper Co., Ltd.), commercially available products of carboxymethylated cellulose include Selenpia CS-01 (manufactured by Oji Paper Co., Ltd.), commercially available products of phosphate-esterified cellulose include AUROVISCO (manufactured by Oji Holdings Corporation), commercially available products of phosphite-esterified cellulose include ELEEX-☆ (Daio Paper Corporation), and unmodified cellulose includes ELLEX-S (Daio Paper Corporation).

[0030] In the present invention, the content of component (B) is not particularly limited, but is preferably 0.5% or more, more preferably 1% or more, and even more preferably 3% or more, relative to the total amount of the powder composition. Furthermore, it is preferably 80% or less, more preferably 50% or less, and even more preferably 20% or less. Also, it is preferably 0.5 to 80%, more preferably 1 to 50%, and even more preferably 3 to 20%. Within this range, it is more preferable because it is superior in terms of storage stability, dispersibility in water, and lack of stickiness when the dispersion is applied to the skin.

[0031] In the present invention, the effects can be obtained by appropriately including component (A) and component (B), but specifying the mass ratio of component (A) and component (B) is more preferable because it provides superior storage stability, dispersibility in water, and non-stickiness when the dispersion is applied to the skin. The mass ratio of component (B) / (A) to component (A) is preferably 0.01 or more, more preferably 0.05 or more, and even more preferably 0.1 or more. It is also preferably 1.5 or less, more preferably 1 or less, and even more preferably 0.5 or less. Furthermore, it is preferably 0.01 to 1.5, more preferably 0.05 to 1, and even more preferably 0.1 to 0.5.

[0032] The present invention may further contain component (C) inorganic powder. Component (C) inorganic powder is a particle of an inorganic substance, and its shape, particle size, and particle structure are not particularly limited; any can be used. For example, examples of shapes include spherical, plate-shaped, needle-shaped, etc., examples of particle size include aerosol-like, fine particles, pigment-grade, etc., and examples of particle structure include porous, non-porous, etc. The present invention is a powder composition containing the above components (A) and (B), but the inclusion of component (C) is preferable from the viewpoint of preventing aggregation of the powder composition containing the above components (A) and (B).

[0033] The particle size of component (C) of the present invention is not particularly limited, but is preferably 1 to 50 μm, more preferably 5 to 30 μm, and even more preferably 8 to 20 μm. Within this range, it is preferable because it provides superior non-stickiness when the dispersion is applied to the skin. In the present invention, the average particle size of component (C) is the median diameter D50 value obtained by measurement using an image analysis device (Luzex AP, manufactured by Nireco). In the case of an asymmetric shape, in the present invention, the median diameter D50 obtained from the distribution of the largest particle size is used as the average particle size.

[0034] The inorganic powder used in component (C) of the present invention is not particularly limited, but examples include white inorganic pigments such as ultramarine titanium oxide, zinc oxide, cerium oxide, and barium sulfate; colored inorganic pigments such as iron oxide, carbon black, titanium-titanium oxide sintered products, chromium oxide, chromium hydroxide, Prussian blue, and ultramarine; talc, mica, muscovite, phlogopite, red mica, biotite, synthetic phlogopite, sericite, synthetic sericite, kaolin, silicon carbide, bentonite, smectite, aluminum oxide, magnesium oxide, zirconium oxide, antimony oxide, diatomaceous earth, aluminum silicate, and aluminum metasilicate. Examples of suitable inorganic powders include, but are not limited to, one or more of these inorganic powders. These include white-based powders such as magnesium, calcium silicate, barium silicate, magnesium silicate, calcium carbonate, magnesium carbonate, bismuth oxychloride, hydroxyapatite, boron nitride, and silica; lustrous powders such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, iron oxide titanium mica, and Prussian blue-treated titanium mica; metallic powders such as aluminum powder, gold powder, and silver powder; and composite powders such as fine-particle titanium oxide-coated titanium mica, fine-particle zinc oxide-coated titanium mica, and barium sulfate-coated titanium mica. Among these, one or more selected from the group consisting of white-based powders are preferred from the viewpoint of storage stability, dispersibility in water, and lack of stickiness when the dispersion is applied to the skin. In particular, one or more selected from silica, mica, and synthetic phlogopite are more preferred.

[0035] Examples of commercially available silica products (component C) include AEROSIL 200, 300 (manufactured by Nippon Aerosil Co., Ltd.), CHIFFONSIL P-3R, HCS 100M5, SILICA MICRO BEAD BA-1, Silica Microbead N-1505, P-1505 (manufactured by JGC Catalysts & Chemicals Co., Ltd.), Cosme Silica CQ4 (manufactured by Fuji Silicia Chemical Co., Ltd.), Gotball E-90C (manufactured by Suzuki Oil & Fat Industry Co., Ltd.), Sunsphere NP-NP-30, NP-100 (manufactured by AGC SI Tech Co., Ltd.), and others. Examples of commercially available mica include JS-1 (manufactured by Sanshin Kogyo Co., Ltd.), MICA POWDER Y-2300, Y-3000, Mica Powder Y-2300WA1 (manufactured by Yamaguchi Mica Co., Ltd.), Eight Pearl FK-1000-S (manufactured by Kakuhachi Gyorinpaku Co., Ltd.), and SE-MA-23 (manufactured by Miyoshi Kasei Co., Ltd.). Examples of commercially available synthetic fluorphlogopite include PDM-5L, 10L, 20L, 40L, SA-PDM-10L, SLM-15, TLF-64, HERIOS R10R, 100S (manufactured by Topy Industries Co., Ltd.), NK-20G, TWINCLEPEARL 400, 511 (manufactured by Nippon Koken Kogyo Co., Ltd.).

[0036] In the present invention, the content of component (C) is not particularly limited, but is preferably 15% or more, more preferably 20% or more, and even more preferably 25% or more, based on the total amount of the powder composition. Also, is preferably 65% ​​or less, more preferably 60% or less, and even more preferably 55% or less. Furthermore, is preferably 15-65%, more preferably 20-60%, and even more preferably 25-55%. Within this range, it is more preferable because it is superior in terms of dispersibility in water and the non-stickiness when the dispersion is applied to the skin.

[0037] The present invention may further contain one or more components selected from the group consisting of sugars and sugar alcohols. The present invention may be any powder composition containing the above components (A) and (B), but the inclusion of component (D) is preferable from the viewpoint of the dispersibility in water of the powder composition containing the above components (A) and (B). Component (D), sugar or sugar alcohol, is not particularly limited, and any can be used. Sugars are oxidation products of polyhydric alcohols and are classified into aldoses, which have an aldehyde group, and ketoses, which have a ketone group. They are also classified according to the number of carbon atoms that make up the sugar, such as triose (3 carbon atoms), tetrose (4 carbon atoms), pentose (5 carbon atoms), hexose (6 carbon atoms), pephthose (7 carbon atoms), etc. The sugar chain becomes longer when a glycosidic bond is formed between a carbonyl group such as the aldehyde group or ketone group and a hydroxyl group. Examples include monosaccharides, disaccharides, oligosaccharides, and polysaccharides. More specifically, examples of monosaccharides include glucose, lactose, threose, arabinose, xylose, galactose, ribose, glucose, sorbose, fructose, and mannose; examples of disaccharides include sucrose, lactose, maltose, cellobiose, and isomaltose; and examples of oligosaccharides include raffinose, panose, maltotriose, melegitose, gentianose, stachyose, and cyclodextrin. Polysaccharides include cellulose, starch, pectin, dextran, and dextrin. Among these, sucrose or dextrin are preferred from the viewpoint of dispersibility in water and non-stickiness when the dispersion is applied to the skin.

[0038] On the other hand, sugar alcohols are compounds produced by the reduction of the carbonyl group of sugars classified as aldoses or ketoses. While not particularly limited, examples include erythritol, sorbitol, mannitol, maltitol, xylitol, galactitol, arabitol, trehalose, pentaerythritol, etc., and one or more of these can be used in combination. Among these, one or more selected from the group consisting of erythritol, sorbitol, mannitol, and maltitol are preferred, one or more selected from the group consisting of erythritol, sorbitol, and mannitol are more preferred, one or more selected from the group consisting of erythritol and mannitol are even more preferred, and mannitol is particularly preferred.

[0039] In the present invention, the content of component (D) is not particularly limited, but is preferably 1% or more, more preferably 3% or more, and even more preferably 5% or more, relative to the total amount of the powder composition. Furthermore, it is preferably 30% or less, more preferably 25% or less, and even more preferably 20% or less. Also, it is preferably 1 to 30%, more preferably 3 to 25%, and even more preferably 5 to 20%. Within this range, it is more preferable because it is superior in terms of dispersibility in water and the non-stickiness when the dispersion is applied to the skin.

[0040] Furthermore, the powder composition of the present invention may contain membrane stabilizers such as cholesterol and / or phytosterols, and can be used as a pre-mixed product. Examples of commercially available mixtures of phospholipids and cholesterol and / or phytosterols include PRESOME CS2-101 (manufactured by Nippon Seika Co., Ltd.), PRESOME C-2 (manufactured by Nippon Seika Co., Ltd.), PHYTOPRESOME (manufactured by Nippon Seika Co., Ltd.), PYTOCOMPO-PP (manufactured by Nippon Seika Co., Ltd.), COMPOSITE-PC (manufactured by Nippon Seika Co., Ltd.), and the like.

[0041] Furthermore, the powder composition of the present invention may also contain sphingolipids. Examples of sphingolipids include ceramides and their derivatives. The sphingolipids in the present invention may be natural extracts or synthetic products. More specifically, natural ceramides such as sphingosine, phytosphingosine, and their long-chain fatty acid amides, such as ceramide EOS (formerly known as ceramide 1), ceramide NS (formerly known as ceramide 2), ceramide NP (formerly known as ceramide 3), ceramide EOH (formerly known as ceramide 4), ceramide AG (formerly known as ceramide 5), and ceramide AP (formerly known as ceramide 6II); sphingophospholipids such as sphingomyelin and phytosphingomyelin, which are phospholipid derivatives of sphingosine and phytosphingosine; and sphingoglycolipids and phytosphingoglycolipids such as cerebrosides and gangliosides, which are glycosides thereof.

[0042] Commercially available sphingolipids include "Ceramide TIC-001" (manufactured by Takasago International Corporation), "Ceramide I" (manufactured by Cosmo Farm Co., Ltd.), "Ceramide III" (manufactured by Cosmo Farm Co., Ltd.), "Ceramide IIIA" (manufactured by Cosmo Farm Co., Ltd.), "Ceramide IIIB" (manufactured by Cosmo Farm Co., Ltd.), and "Ceramide VI" (manufactured by Cosmo Farm Co., Ltd.).

[0043] In addition to the above components (A) to (D), the powder composition of the present invention may contain, for example, oily components, powders other than component (C), surfactants other than component (A), fibers other than component (B), alcohols, aqueous components such as humectants other than component (D), antioxidants, defoamers, cosmetic ingredients, preservatives, fragrances, etc., to the extent that they do not interfere with the effects of the present invention.

[0044] The average particle size of the powder composition of the present invention is not particularly limited, but 1 to 100 μm is preferred. Within this range, it is more preferable because it exhibits excellent dispersibility in water and a lack of stickiness when the dispersion is applied to the skin.

[0045] The powder composition of the present invention is in a state where the water in the vesicles has been removed by drying, and from the viewpoint of storage stability, the water content of the powder composition is preferably 5% or less. The method for measuring the moisture content is not particularly limited, but it can be determined by the loss on drying method. For example, when heated at 105°C for 30 minutes using MOC63u (manufactured by Shimazu Seisakusho Co., Ltd.), the loss on drying (%) can be calculated as: Mass reduced by drying (mg) / Amount collected (mg) × 100.

[0046] The method for producing the powder composition of the present invention is not particularly limited, but for example, water or an aqueous solution containing component (A) is heated to 70°C, uniformly mixed in a homomixer, and cooled to room temperature to obtain a vesicle dispersion. Component (B), and optionally (C) to (D), are also added to water or an aqueous solution and uniformly mixed in a homomixer. In the case of spray drying, the aqueous solution containing component (A) and the aqueous solutions containing component (B), and optionally (C) to (D), may be mixed beforehand and then sprayed, or they may be sprayed simultaneously from separate nozzles during spraying. In spray drying, water is dried and removed using a spray dryer, and it is preferable to remove the water at a temperature of 100°C or higher. In the case of freeze-drying, the aqueous solution containing component (A) and the aqueous solutions containing component (B), and optionally (C) to (D), are mixed beforehand, and then a predetermined amount is divided and filled into vials or molds, and the freeze-drying operation is performed. In freeze-drying, water is sublimated and removed using a freeze-dryer, and it is preferable to rapidly freeze to a freezing temperature of -20°C or lower and to sublimate the water under reduced pressure conditions of 10 Pa or lower. In spray freeze-drying, an aqueous solution containing component (A), component (B), and optionally aqueous solutions containing (C) to (D) are pre-mixed and then sprayed into liquid nitrogen for pre-freezing. After that, the water is sublimated and removed using a freeze-dryer. It is preferable to rapidly freeze the mixture to a freezing temperature of -20°C or below and to sublimate the water under reduced pressure conditions of 10 Pa or less. If necessary, the mixture may be pulverized using a grinder or mill after freeze-drying and spray freeze-drying to produce a powder.

[0047] Examples of spray dryers include the L / OC series (manufactured by Okawara Chemical Machinery Co., Ltd.) and DL410 (manufactured by Yamato Scientific Co., Ltd.). Examples of vacuum freeze dryers include the RL-B series (manufactured by Nissei Co., Ltd.) and FD-20STU (manufactured by Nippon Techno Service Co., Ltd.). An example of a spray freeze dryer is the SFD-1000 model (manufactured by Tokyo Rikakikai Co., Ltd.).

[0048] The method of powdering is not particularly limited, but for example, the dispersion obtained by dispersing components (A) to (D) in water can be powdered by spray drying, freeze-drying, spray freeze-drying, freeze-drying and grinding. In the present invention, powdering by freeze-drying and spray freeze-drying is preferred.

[0049] As one embodiment of the powder composition of the present invention, for example, in freeze-drying, spray freeze-drying, and freeze-drying pulverization, the state of the powder composition of the present invention has a sponge-like porous structure due to the sublimation of water, and its form can be spherical, flaky, block-like, or any other form.

[0050] Furthermore, in one embodiment, during spray drying, the powder composition of the present invention generally takes a spherical form, but it can also take any form, such as flaky or blocky. In addition, if there is a nucleating substance, the powder composition may take a form in which particles are formed on the surface of the nucleus during spray drying. In the present invention, for example, component (C) or component (D) can act as nuclei. The state of the powder composition can be observed with a scanning electron microscope (JEOL JCM-6000Plus NeoScope desktop scanning electron microscope).

[0051] The powder composition of the present invention is not particularly limited and can be used in cosmetics, topical skin preparations, foods, pharmaceuticals, etc. Examples include makeup cosmetics such as foundation, primer, face powder, concealer, eyeshadow, blush, lipstick, and eyebrow products, and skincare cosmetics such as body powder and antiperspirant powder. Topical skin preparations include topical liquids, topical gels, ointments, and patches. As foods and pharmaceuticals, they can be administered orally and can take various forms such as powder, granules, tablets, capsules, etc. In the present invention, it is preferable to use it in topical skin preparations or cosmetics, and more preferable to use it in cosmetics.

[0052] When the powder composition of the present invention is used in cosmetics, it can be used as is, but it is preferable to use it in combination with water to further improve usability. In particular, it is preferable to use it as a vesicle dispersion in a ready-to-use mixing form, where it is mixed with water immediately before use, as this allows for stable delivery of the vesicle composition to the skin. The water used when forming a vesicle dispersion in a ready-to-use mixing form can be purified water, hot spring water, deep sea water, steam-distilled water from plants, or a cosmetic composition in which water forms the outermost layer. Examples of cosmetic compositions in which water forms the outermost layer include aqueous cosmetics, oil-in-water emulsion cosmetics, and water-in-oil emulsion cosmetics.

[0053] Furthermore, since vesicles dispersed in water have poor storage stability, it is preferable that the cosmetic powder composition (hereinafter referred to as "the cosmetic") contains substantially no water. Here, water refers to water contained in purified water, hot spring water, deep sea water, steam distilled water from plants, etc. Here, "substantially contained" means that it contains no water at all, or if it does contain water, it is preferably 5% or less, more preferably 1% or less, and even more preferably 0.1% or less.

[0054] The method of mixing at the time of use is not particularly limited, and the cosmetic composition and water can be mixed at the time of use. Here, the water used for mixing at the time of use is not particularly limited, and RO water, deionized water, distilled water, purified water, etc. can be used. Also, when mixing at the time of use, the cosmetic composition only needs to be dispersed in water, and the water may be derived from the cosmetic composition. Here, the cosmetic composition containing water is not particularly limited, and any type can be used, but one or more types selected from the group consisting of aqueous type, oil-in-water type, and water-in-oil type are preferred. For example, lotions, emulsions, creams, aqueous gels, serums, packs, sunscreens, primers, foundations, etc. can be used. Here, in order to distinguish the cosmetic composition from the cosmetic composition containing water, the cosmetic composition will be referred to as cosmetic composition (X), and the cosmetic composition containing water will be referred to as cosmetic composition (Y). Cosmetic composition (X) and cosmetic composition (Y) are not particularly limited, and one or more types may be used in combination.

[0055] The method of use as a ready-to-use mixed cosmetic is not particularly limited. For example, cosmetic (X) and cosmetic (Y) can be mixed in fixed amounts in the palm of the hand. The mixing method is not particularly limited and includes mixing in the palm of the hand, mixing fixed amounts of cosmetic (X) and cosmetic (Y) in a dish-shaped container, and mixing fixed amounts of cosmetic (X) and cosmetic (Y) by shaking in a container. Here, fixed amount refers to the amount to be adjusted at the time of use and corresponds to the amount actually used. For example, equal amounts such as mixing 1g each of cosmetic (X) and cosmetic (Y) can be selected, but it is not limited to equal amounts. For example, the mass ratio (X) / (Y) of cosmetic (X) and cosmetic (Y) is not particularly limited, but from the viewpoint of ensuring an effective supply of vesicles to the skin and living body, it is preferable to have a ratio of 0.01 or higher. Furthermore, from the viewpoint of dispersibility in water, (X) / (Y) is preferably 0.5 or lower, more preferably 0.4 or lower, and even more preferably 0.3 or lower. Furthermore, a value of 0.01 to 0.5 is preferred, 0.01 to 0.4 is more preferred, and 0.01 to 0.3 is even more preferred. [Examples]

[0056] The present invention will be described in detail below with reference to examples. However, these examples do not limit the present invention in any way.

[0057] Examples 1-19, Comparative Examples 1-4: Powder Compositions Powder compositions were prepared according to the formulations shown in Tables 1-3 below, and evaluated for a. storage stability and b. dispersibility in water using the evaluation methods described below. The results are also shown in Tables 1-3.

[0058] (Evaluation method) The following evaluations were conducted to confirm the effectiveness of each sample for items (a) and (b). For (a), a quantitative test was performed on one sample, and for (b), each sample was tested by five cosmetic evaluation specialists, who evaluated it on a four-point scale according to the evaluation criteria below and made a judgment according to the judgment criteria below.

[0059] <Evaluation Criteria> (i) Evaluation of storage stability: 2 g of the powder composition was filled into a 3 mL vial and stored for one month in a constant temperature bath (temperature 40°C, humidity 75%). The mixture was then passed through a 200 mesh sieve, and the aggregated portion remaining on the sieve was evaluated as aggregate. Aggregation rate % = (amount remaining on sieve g / total amount 2 g) × 100. (b) Evaluation of dispersibility in water: 0.05 g of the powder composition and 1 g of purified water were measured into a 15 ml Falcon tube and shaken using a vortex mixer to evaluate their dispersibility in water.

[0060] <(i) Evaluation Criteria> (Rating): (Evaluation) 3: A state where aggregation is less than 5% of the total. 2: A state in which aggregation accounts for 5% or more but less than 20% of the total. 1: A state in which aggregation accounts for 21% or more but less than 80% of the total. 0: A state where aggregation accounts for 80% or more of the total. (b) Evaluation Criteria (Rating): (Evaluation) 3. Disperse uniformly within a mixing time of less than 5 seconds. 2: Disperse evenly with a mixing time of 5 seconds to less than 10 seconds. 1: A state in which the mixture is uniformly dispersed after a mixing time of 10 seconds or more but less than 15 seconds. 0: The mixture remains uneven and does not disperse even after mixing for 15 seconds or more. <Judgment criteria> (Judgment): (Evaluation) ◎: Total score of 12 or more ○: Total score of 8 or more but less than 12 △: Total score between 4 and 8 ×: Total score less than 4

[0061] [Table 1]

[0062] [Table 2]

[0063] [Table 3]

[0064] *1: PHOSPHOLIPON 90H (manufactured by Lipoid) *2: Egg yolk lecithin PL-100P (manufactured by Kewpie Corporation) *3: PHOSPHOLIPON 90G (manufactured by Lipoid) *4: Leocrysta C-2SP (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) *5: Ceolus PH-101 (manufactured by Asahi Kasei Corporation) *6: Metrozes 65H4000 (manufactured by Shin-Etsu Chemical Co., Ltd.) *7: PDM-10L (manufactured by Topi Industries Co., Ltd.)

[0065] (Methods for producing the powder compositions of Examples 1-19 and Comparative Examples 1-4) A: Add purified water to No. 1-8 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to No. 9-18 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C was spray-dried using a spray dryer to obtain a powder composition.

[0066] [Table 4]

[0067] (Method for producing the powder compositions of Examples 20-25) A: Add purified water to No. 1-8 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to No. 9-18 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C was freeze-dried in a freeze-dryer to obtain a powder composition.

[0068] Examples 26-34: Cosmetic mixture to be mixed before use The aqueous compositions of the formulations shown below were mixed with the powder compositions of Examples 1, 9, 13, 20, 21, 23, and 24 to prepare ready-to-use mixed cosmetics. The ratios of the powder and aqueous compositions used in the ready-to-use mixed cosmetics, and their evaluation results, are shown in Table 5.

[0069] <Formulation of aqueous composition> (Ingredients) (%) 1. Purified water remaining amount 2,1,3-Butylene glycol 6 3. Glycerin 4 4. Polyoxyethylene polyoxypropylene Decyltetradecyl ether 0.6 5.Fragrance 0.1

[0070] (Method for producing aqueous compositions) A: Mix ingredients No. 2 through 5 evenly. No. 1 was added to B:A and mixed uniformly to obtain an aqueous composition.

[0071] [Table 5]

[0072] (Method for manufacturing a ready-to-use cosmetic mixture) A: Mix ingredients No. 1 to 8 uniformly to obtain a ready-to-use cosmetic mixture.

[0073] Regarding the ready-to-use cosmetic formulations, the dispersibility of the powder composition in the aqueous composition and the lack of stickiness when the dispersed product is applied to the skin after being dispersed in the aqueous composition were evaluated. For the dispersibility of the powder composition in the aqueous composition, the evaluation was performed under the same conditions as in (b) above, except that the water was changed to the aqueous composition of the above formulation, and the evaluation was performed using the same evaluation criteria as in (b) above. (c) For the lack of stickiness when the dispersed product is applied to the skin after being dispersed in the aqueous composition, the evaluation was performed using the evaluation criteria below, and the judgment was made based on the judgment criteria below.

[0074] (Evaluation method) (h) Evaluation of the non-stickiness when the dispersion is applied to the skin: Five cosmetic evaluation specialists took 0.05 g of the powder composition and 1 g of the aqueous composition of the above formulation in their palms, mixed them with their fingers to disperse the mixture, and then applied the resulting dispersion to the skin. They performed a sensory evaluation of the degree of stickiness based on the evaluation criteria below, assigned scores, and made judgments based on the judgment criteria below. <(h) Evaluation Criteria> (Rating): (Evaluation) 3: Very good 2: Good 1: Bad 0: Very poor <Judgment criteria> (Judgment): (Evaluation) ◎: Total score of 12 or more ○: Total score of 8 or more but less than 12 △: Total score between 4 and 8 ×: Total score less than 4

[0075] The ready-to-use cosmetic compositions of Examples 26-34 exhibited excellent dispersibility in aqueous compositions and a lack of stickiness when the dispersion was applied to the skin.

[0076] Example 35: Powder composition (Ingredients) (%) 1. Phospholipids (hydrogenated soybeans) *1 30 2. Phospholipids (unhydrogenated soybeans) *3 10 3. Cellulose nanofiber (pure content) *4 10 4.Synthetic phlogopite*7 5 5. Silica *8 remaining amount 6. Mannitol 10 7. Methylparaben 1 8. Phenoxyethanol 2 9. Citric acid 1 10. Sodium citrate 2 11. EDTA-2Na 1 12. Water-soluble collagen 2 13. Kaiketsu Extract 2 14. Aloe vera leaf extract 2 15.Fragrance 0.5 16. Red No. 226 0.1 *8: Silica microbead P-1505 (manufactured by JGC Catalysts & Chemicals Co., Ltd.)

[0077] (Manufacturing method) A: Add purified water to No. 1-2, 8, and 12-16 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, then process under high pressure using a microfluidizer, and cool to room temperature. B: Add purified water to Nos. 3-7 and 9-11 to a total of 100 parts by mass, and mix uniformly using a homomixer. C: A and B were mixed using a Y-shaped nozzle immediately before spraying, and then spray-dried with a spray dryer to obtain a powder composition.

[0078] The powder composition of Example 35 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0079] Example 36: Cosmetic mixture to be mixed before use <Lotion formulation> (Ingredients) (%) 1. Purified water remaining amount 2,1,3-Butylene glycol 10 3. Glycerin 5 4. Triethanolamine 0.5 5. (Acrylates / Alkyl Acrylate) (C10-C30) Crosspolymer 0.3 6. Methylparaben 0.2 7. Mineral oil 5 8. Cetyl ethylhexanoate 5 9. Triethylhexanoin 2 10. Sorbitan isostearate 0.3 11. Polysorbate 80 0.3 12. Stearic acid 0.5 13. Cetostearyl alcohol 0.2 14. Behenyl alcohol 0.2 15. Glyceryl stearate 0.2 16. Phenoxyethanol 0.3 17.Fragrance 0.2

[0080] (Manufacturing method) A: Disperse ingredients No. 1-6 uniformly at 70°C. B: Disperse ingredients No. 7-17 uniformly at 70°C. Add A to C:B and emulsify at 70°C. D;C was cooled to 40°C to obtain an emulsion.

[0081] 0.1 g of the powder composition of Example 35 and 1 g of the emulsion of the above formulation were mixed in the palm of the hand just before use and applied to the skin. As a result, the powder composition of Example 35 was excellent in terms of dispersibility in the emulsion of the above formulation and the lack of stickiness when the dispersion was applied to the skin.

[0082] Example 37: Powder composition (Ingredients) (%) 1. Phospholipid / cholesterol mixture *9 15 2. Phospholipid / ceramide mixture *10 15 3. Cellulose nanofiber (pure content) *11 10 4. Synthetic fluorphlogopite*7 remaining amount 5. Cornstarch 10 6. Dextrin 15 7. Sodium dehydroacetate 2 8. Phenoxyethanol 2 9. Sodium chloride 2 10. Tocopherol 2 11. Retinol 2 12. Niacinamide 3 13. Tranexamic acid 2 14. Lavender oil 0.2 15. Yellow iron oxide 0.5 16. Yellow No. 4 0.1 *9: PRESOME CS2-101 (manufactured by Nippon Seika Co., Ltd.) *10: PRESOME Cera-236 (manufactured by Nippon Seika Co., Ltd.) *11: AUROVISCO (manufactured by Oji Holdings Corporation)

[0083] (Manufacturing method) A: Add purified water to components 1 and 2 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to components 3-16 to a total of 100 parts by mass, and mix uniformly using a homomixer. Mix A uniformly with C:B. D:C was spray-dried using a spray dryer to obtain a powder composition.

[0084] The powder composition of Example 37 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0085] Example 38: Cosmetic mixture to be mixed before use <Primer formulation> (Ingredients) (%) 1. Purified water remaining amount 2. Triethanolamine 1 3. Carbomer 0.2 4. Mineral oil 10 5. Ditylpolysiloxane (kinematic viscosity 6CS at 25°C) 10 6. Ethylhexyl Methoxycinnamate 5 7. Bis-ethylhexyloxyphenol methoxyphenyl triazine 1.5 8. Diethylamino hydroxybenzoyl hexyl benzoate 0.8 9. Stearic acid 1.5 10. Glyceryl stearate 0.4 11. Cetearyl alcohol 0.4 12. Polysorbate 80 1 13. PEG-10 Hydrogenated Castor Oil 0.5 14. Xanthan gum 0.1 15. Ethanol 5 16. Phenoxyethanol 0.2 17. Methylenebisbenzotriazolyltetramethylbutylphenol 2.5 18. Polyglyceryl-10 Laurate 0.5 19.1,3-Butylene glycol 10 20. Polysorbate 80 0.5 21. PEG-10 Hydrogenated Castor Oil 0.2 22. Lecithin 0.1 23. Nylon-12 1.5 24. Silica 2% treated titanium dioxide (average particle size 0.3 μm) 5 25. Talc 1.5 26. Ultramarine 0.5 27. Red iron oxide 0.2

[0086] (Manufacturing method) A: Disperse ingredients No. 1-3 uniformly at 75°C. B: Disperse ingredients No. 4-13 uniformly at 75°C. Add A to C:B and emulsify at 75°C. Cool D:C to 40°C. E: Add No. 14-18 to D and mix uniformly. F: Process No. 19-27 using a three-roller system. G:F was added to E and mixed uniformly to obtain the base.

[0087] 0.3 g of the powder composition of Example 37 and 1.5 g of the base of the above formulation were mixed in the palm of the hand and applied to the skin. As a result, the powder composition of Example 37 exhibited excellent dispersibility with the base of the above formulation and a lack of stickiness when the dispersion was applied to the skin.

[0088] Example 39: Powder composition (Ingredients) (%) 1. Phospholipids (unhydrogenated soybeans) *3 20 2. Cellulose nanofiber (pure content) *12 10 3. Mica*13 remaining amount 4. Cellulose powder *14 10 5. Dextrin 10 6. Mannitol 10 7. Sodium benzoate 2 8. Phenoxyethanol 2 9. Triethanolamine 2 10. Heparin-like substances 2 11. Sodium Hyaluronate 3 12. Hydrolyzed Hyaluronic Acid 2 13. Sodium acetylated hyaluronate 2 14. Ascorbyl tetrahexyldecanoate *15 2 15. Phytosteryl oleate 2 16. Squalane 2 17. Yellow iron oxide 0.5 18. Red iron oxide 0.3 19. Black iron oxide 0.1 *12: Serenpia CS-01 (manufactured by Oji Paper Co., Ltd.) *13: MICA POWDER Y-2300 (manufactured by Yamaguchi Mica Co., Ltd.) *14: CELLUKOBEADS D-5 (manufactured by Daito Kasei Kogyo Co., Ltd.) *15: NIKKOL VC-IP (manufactured by Nikko Chemicals Co., Ltd.)

[0089] (Manufacturing method) A: Add purified water to No. 1, 5, 8, and 14-19 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, then process under high pressure using a microfluidizer, and cool to room temperature. B: Add purified water to No. 2-4, 6-7, and 9-13 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C was freeze-dried using a freeze-dryer to obtain a powder composition.

[0090] The powder composition of Example 39 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0091] Example 40: Cosmetic mixture to be used <Foundation Formula> (Ingredients) (%) 1. Silicone-treated titanium dioxide (average particle size 0.3 μm) 10 2. Silicone-treated titanium dioxide (average particle size 0.05 μm) 3 3. Silicone-treated zinc oxide (average particle size 0.035 μm) 5 4. Triethoxycaprylylsilane 2% treated yellow iron oxide 0.7 5. Triethoxycaprylylsilane 2% treated red iron oxide 0.4 6. Triethoxycaprylylsilane 2% treated black iron oxide 0.1 7. Talc 2.5 8. Octyl palmitate 5 9. PEG-9 Polydimethylsiloxyethyl Dimethicone 1 10. PEG-9 polydimethylsiloxyethyl dimethicone laurate 0.7 11. Disteardimonium hectorite 0.8 12. Stearalkonium hectorite 0.4 13. Methyltrimethicone 5 14. Dimethylpolysiloxane (kinematic viscosity at 25°C: 2CS) 20 15. Ethylhexyl Methoxycinnamate 7 16. Diethylamino hydroxybenzoyl hexyl benzoate 1 17. Silica 1 18.Fragrance 0.2 19. Purified water remaining amount 20. Ethanol 5 21.1,3-Butylene glycol 5 22. Methylenebisbenzotriazolyltetramethylbutylphenol 1.7 23. Polyglyceryl-10 Laurate 0.3 24. Sodium Chloride 0.3 25. Phenoxyethanol 0.2

[0092] (Manufacturing method) A: Process items No. 1-13 using a three-roller system. B: Distribute items No. 14-18 evenly. Add C:A to B and mix uniformly. D: Distribute items No. 19-25 evenly. E:D was added to C and emulsified to obtain a foundation.

[0093] 0.05 g of the powder composition of Example 39 and 0.5 g of the foundation of the above formulation were mixed in the palm of the hand and applied to the skin. As a result, the powder composition of Example 39 showed excellent dispersibility with the foundation of the above formulation and lack of stickiness when the dispersion was applied to the skin.

[0094] Example 41: Powder composition (Ingredients) (%) 1. Polyoxyethylene sorbitan stearate *16 10 2. Cellulose nanofiber (pure content) *12 2 3. Mannitol 10 4. Sucrose remaining amount 5. Chlorphenesin 0.2 6. Phenoxyethanol 1 7. Citric acid 0.2 8. Sodium citrate 2.5 *16: NIKKOL BPS-5 (manufactured by Nikko Chemicals Co., Ltd.)

[0095] (Manufacturing method) A: Add purified water to component 1 to a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to components 2-8 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C was pre-frozen in a spray freeze-dryer and then freeze-dried to obtain a powder composition.

[0096] The powder composition of Example 41 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0097] Example 42: Powder composition (Ingredients) (%) 1. Polyoxyethylene sorbitan stearate *17 5 2. Sorbitan monooleate 5 3. Polyoxyethylene stearyl ether 5 4. Cellulose nanofiber (pure content) *12 1 5. Dextrin 5 6. Sucrose remaining amount 7. Chlorphenesin 0.2 8. Phenoxyethanol 0.5 9. Citric acid 0.2 10. Sodium citrate 2.5 *17: Tween61 (SIGMA)

[0098] (Manufacturing method) A: Add purified water to components 1-3 to a total volume of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to components 4-10 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C was freeze-dried in a freeze-dryer to obtain a powder composition.

[0099] The powder composition of Example 42 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0100] Example 43: Powder composition (Ingredients) (%) 1. Phospholipids (unhydrogenated soybeans) *3 20 2. Phospholipids (hydrogenated soybeans) *1 10 3. Retinyl palmitate*18 5 4. Cellulose nanofiber (pure content) *12 2 5. Sucrose remaining amount 6. Chlorphenesin 0.2 7. Phenoxyethanol 1 8. Citric acid 0.2 9. Sodium citrate 2.5 *18: RIKEN A Palmitate 1000(E)

[0101] (Manufacturing method) A: Dissolve components 1-3 in 10 parts by mass of ethanol, then add purified water to make a total of 100 parts by mass, heat to 70°C, mix uniformly using a homomixer, and then cool to room temperature. B: Add purified water to components 4-9 to a total of 100 parts by mass, and mix uniformly using a homomixer. Add A to C:B and mix uniformly. D:C is pre-frozen using a spray freeze-dryer and then freeze-dried. E:D was ground using a hammer mill to obtain a powder composition.

[0102] The powder composition of Example 43 exhibited excellent storage stability, dispersibility in water, and non-stickiness when the dispersion was applied to the skin.

[0103] Example 44: Cosmetic mixture to be used <Lotion formula> (Ingredients) (%) 1. Dipotassium glycyrrhizinate 0.1 2. Purified water remaining amount 3. Glycerin 8 4. Ethanol 5 5. Dipropylene glycol 7 6.1,3-Butylene glycol 5 7. Sodium monohydrogen phosphate 0.05 8. Sodium dihydrogen phosphate 0.02 9. Sorbitan sesquioleate 0.02 10. Polyoxyethylene hydrogenated castor oil 0.08 11. Polyoxyethylene alkyl (12-15) Ether phosphate (8E.O) 0.02 12. Glyceryl tri-2-ethylhexanoate 0.1 13.Fragrance 0.01 14. Phenoxyethanol 0.1

[0104] A: Heat ingredients 9-14 to 50°C and dissolve and mix them uniformly. B: Dissolve components 1-8 uniformly at room temperature. A was added to C:B and mixed, then emulsified in a homomixer to obtain a lotion.

[0105] For the powder compositions of Examples 41 to 43, 3g of each powder composition was placed in three separate dropper bottles, one for each example. 15g of the lotion formulation described above was mixed in each dropper bottle just before use, and then applied to the skin. As a result, all of the powder compositions of Examples 41 to 43 exhibited excellent dispersibility in the lotion formulation described above, and the dispersion did not feel sticky when applied to the skin.

Claims

1. A powder composition containing the following components (A) and (B), which forms vesicles when dispersed in water. (A) One or more surfactants selected from the group consisting of phospholipids and nonionic surfactants. (B) Cellulose nanofibers

2. The powder composition according to claim 1, wherein the mass ratio of component (B) to component (A) is (B) / (A) = 0.01 to 1.

5.

3. Furthermore, the powder composition according to claim 1 or 2, further comprising component (C) inorganic powder.

4. The powder composition according to claim 3, wherein the component (C) is one or more inorganic powders selected from the group consisting of silica, mica, and synthetic fluorphlogopite.

5. Furthermore, the powder composition according to any one of claims 1 to 4 contains one or more selected from the group consisting of component (D) sugars and sugar alcohols.

6. The powder composition according to any one of claims 1 to 5, wherein the water content of the powder composition is 5% by mass or less.

7. A ready-to-use cosmetic composition comprising mixing the powder composition according to any one of claims 1 to 6 with water at the time of use.

8. A method of use comprising mixing the powder composition according to any one of claims 1 to 6 with water and applying it to the skin (excluding medical procedures on humans).

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