In vitro and in vivo optically controlled removal of targeted objects
IR700 conjugates enable light-controlled removal of target biomolecules by changing hydrophilicity to hydrophobicity, addressing the challenge of isolating and removing biomolecules from complex mixtures, improving purification and drug control.
JP7887443B2Active Publication Date: 2026-07-09THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
- Filing Date
- 2024-04-26
- Publication Date
- 2026-07-09
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Abstract
To provide photo-controlled removal of targets in vitro and in vivo.SOLUTION: This disclosure provides IR700-molecule conjugates and methods of using them to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule to a hydrophobic molecule, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory.SELECTED DRAWING: None
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