RTS,S formulation stabilised by an agent comprising a thiol.

Abstract

The present invention relates to a component for a malaria vaccine comprising: a) an immunogenic particle RTS,S and / or b) an immunogenic particle derived from the CS protein of one or more P. vivax strains and S antigen from Hepatitis B and optionally unfused S antigen, or c) an immunogenic particle comprising RTS, CSV-S and optionally unfused S antigen, and d) a stabilizing agent comprising a stabilizing agent with at least one thiol functional group, or mixtures thereof. Methods for preparing the component, its use in medicine, particularly in the prevention of malarial infections, compositions / vaccines containing the component and use of the latter, particularly in therapy are also disclosed.