Aspherical intraocular lens, design method for same, and production method for same

Abstract

The present invention provides an intraocular lens comprising a power profile V that is accommodated within a power profile convergence region which is obtained from each combination of power profiles Va and Vb when a position ra is defined as the intersection on the horizontal axis between the power profile Va and the power profile Vb. The power profile Va, which is for a first region, is obtained by adding, to the vertical axis value at each horizontal axis value of an aspherical reference power profile W, a value that is obtained by multiplying, by a prescribed percentage α (where α is not less than 10% and not more than 50%) a value obtained by subtracting, from a base power, the vertical axis value at each horizontal axis value of the aspherical reference power profile W. The power profile Vb, which is for a second region, is obtained by adding, to the horizontal axis value at each vertical axis value of the aspherical reference power profile W, a value that is obtained by multiplying, by a prescribed percentage β (where β is not less than 10% and not more than 50%), a value obtained by subtracting, from the maximum value rmax of the horizontal axis of the aspherical reference power profile W, the horizontal axis value at each vertical axis value of the aspherical reference power profile W. The present invention also provides technology related to the intraocular lens.

Description

Aspheric intraocular lens, its design method, and its manufacturing method

[0001] The present invention relates to an aspheric intraocular lens, a method for designing the same, and a method for manufacturing the same.

[0002] Intraocular lenses are known to play a role in correcting vision after the removal of a cloudy lens due to cataracts. For example, when the lens becomes cloudy due to cataracts, vision can be restored by surgically inserting an artificial intraocular lens into the lens capsule to replace the cloudy lens.

[0003] In

[0007] of Patent Document 1, it is stated that the objective is to obtain an intraocular lens that maintains the advantage of conventional aberration-reducing intraocular lenses, that is, that images are clearly visible, while causing little reduction in contrast even when the optical axis of the intraocular lens is misaligned with the optical axis of the eyeball when inserted into the eye.

[0004] In order to solve this problem, Patent Document 1, etc., describes that when a power distribution that is set so as to cancel out the spherical aberration of the cornea when the intraocular lens is inserted into the eye is taken as a reference power distribution, the region near the center of this intraocular lens has a power distribution that includes at least one positive power deviation region, which is a region having a power greater than the power represented by the reference power distribution, and at least one negative power deviation region, which is a region having a power less than the power represented by the reference power distribution, thereby reducing the decrease in contrast that occurs when the optical axis of the intraocular lens inserted into the eye deviates from the optical axis of the eyeball.

[0005] Other known intraocular lenses include:

[0006] For example, Patent Documents 2 and 3 propose intraocular lenses that do not add new spherical aberration to the existing spherical aberration of the cornea (Claim 1 of Patent Document 2, Claim 1 of Patent Document 3). These intraocular lenses have a constant power value throughout the entire optical zone. Because no spherical aberration is added to the ocular optical system, they are not affected by image quality degradation due to lens displacement and tilt.

[0005] of Patent Document 2 proposes an aspherical intraocular lens in which the amount of negative spherical aberration is less than the amount required to offset the positive spherical aberration of the cornea.

[0007] Patent Document 4 proposes an aspherical intraocular lens that reduces the spherical aberration of the cornea of ​​an average human eye in order to minimize the spherical aberration of the optical eye system (claims 1, 13, etc. of Patent Document 4). The power value of such an aspherical intraocular lens decreases as the radius of the lens increases. In order for this lens to provide high image quality, it is necessary to keep the lens displacement and tilt low in aphakic patients.

[0008] Patent Document 5 proposes an aspheric intraocular lens that can balance image contrast and depth of focus within an acceptable range, especially under conditions of a large pupil (e.g., 4.5 to 5 mm) (Claim 1 of Patent Document 5).

[0009] Patent Document 6 proposes an aspheric intraocular lens that provides minimal sensitivity of optical performance under the occurrence of lens concentration and lens tilt: the power value of the lens first decreases and then increases as the lens radius increases (black circles in Figure 6 of Patent Document 6).

[0010] Japanese Patent Application Laid-Open No. 2007-330478 US2005 / 0203619 WO2004 / 090611 US2004 / 0088050 WO2006 / 060477 WO2007 / 128423

[0011] After the intraocular lens is inserted into the eye, it is possible that the center of the optical axis of the intraocular lens may be decentered from the center of the cornea, or that the optical axis of the intraocular lens may be tilted from the thickness direction of the cornea (the direction of the eye axis).

[0012] Furthermore, it is expected that a wearer with an intraocular lens inserted into his or her eye will work outdoors where there is a lot of light, or indoors where there is relatively little light (or in a dark place), which means that the diameter of the wearer's pupils may change.

[0013] An object of the present invention is to provide an intraocular lens and related art that can maintain good image quality while being robust in terms of changes in image quality with respect to the above-mentioned displacement, tilt, and pupil diameter.

[0014] A first aspect is an intraocular lens having at least two adjacent vision correction regions that are concentric with a lens center O having a predetermined base power set thereto, wherein the vision correction regions are set as second regions surrounding the first region, in order from the first region including the lens center O toward the radially outward direction, and wherein in a power profile in which the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)) represents the power, when the position of a first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and when the power profile of a virtual aspherical lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea is set as an aspherical reference power profile W, The intraocular lens is provided with: a power profile Va for a first region obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power, multiplying the result by a predetermined percentage α (α is 10% or more and 50% or less), and adding the result to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; and a power profile Vb for a second region obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W, multiplying the result by a predetermined percentage β (β is 10% or more and 50% or less), and adding the result to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; and a power profile V that fits within a collection region of power profiles obtained by combinations of the power profiles Va and Vb, when the intersection of the above is set to position ra on the horizontal axis.

[0015] A second aspect is the intraocular lens according to the first aspect, wherein r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

[0016] The third aspect is an intraocular lens according to the first aspect, in which, at each horizontal axis value of the power profile V, the maximum positive value among the values ​​obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V is at position r1.

[0017] A fourth aspect is the intraocular lens according to the first aspect, wherein the maximum value rmax on the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0018] A fifth aspect is the intraocular lens according to the first aspect, which comprises one or more additional regions extending radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

[0019] A sixth aspect is the intraocular lens according to the first aspect, wherein the power profile V is expressed by a polynomial.

[0020] A seventh aspect is an intraocular lens according to the first aspect, further comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting incident light beams onto the retina.

[0021] An eighth aspect is an intraocular lens having at least two adjacent regions for vision correction that are concentric with a lens center O having a predetermined base power set thereto, wherein the regions for vision correction are set as second regions surrounding the first region, in order from a first region including the lens center O toward the radially outward direction, and wherein in a power profile where the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)) represents the power, when the position of a first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and when the power profile of a virtual aspherical lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea is set as an aspherical reference power profile W, in the first region, the average value of the vertical axis values ​​of the power profile V1 for the first region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W, In the second region, the average value of the vertical axis values ​​of the power profile V2 for the second region is larger than the average value of the vertical axis values ​​of the aspherical reference power profile W; in the power profile V1 for the first region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V1 continuously increases at each horizontal axis value; in the power profile V2 for the second region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2 continuously decreases at each horizontal axis value; in the power profile V, the position r1 is the positive maximum value among the values ​​obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2; and the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value at the maximum value rmax of the horizontal axis of the power profile V is less than 0.25D.

[0022] A ninth aspect is the intraocular lens according to the eighth aspect, wherein the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three times or more the absolute value of the average value of the tangent slope of the power profile V1 in the first region.

[0023] A tenth aspect is the intraocular lens according to the eighth aspect, wherein r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

[0024] An eleventh aspect is the intraocular lens according to the eighth aspect, wherein the maximum value rmax on the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0025] A twelfth aspect is the intraocular lens according to the eighth aspect, comprising: a power profile Va for a first region obtained by multiplying a value obtained by subtracting a vertical axis value at each horizontal axis value of the aspherical reference power profile W from a base power by a predetermined percentage α (α is 10% or more and 50% or less), and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; and a power profile Vb for a second region obtained by multiplying a value obtained by subtracting a horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less), and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; and a power profile V that falls within a collection region of power profiles obtained by combinations of the power profiles Va and Vb, when the intersection of the above is set to a position ra on the horizontal axis.

[0026] A thirteenth aspect is the intraocular lens according to the eighth aspect, which comprises one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

[0027] A fourteenth aspect is the intraocular lens according to the eighth aspect, wherein the power profile V is expressed by a polynomial.

[0028] A fifteenth aspect is an intraocular lens according to the eighth aspect, which comprises one or more additional regions extending radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting incident light beams onto the retina.

[0029] A sixteenth aspect is an intraocular lens having at least two adjacent regions for vision correction that are concentric with a lens center O having a predetermined base power set thereto, wherein the regions for vision correction are set, in order from a first region including the lens center O toward the radially outward direction, as an intermediate region surrounding the first region and a second region surrounding the intermediate region, and in a power profile in which the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)), when the power profile of a virtual aspherical lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea is set as an aspherical reference power profile W, a power profile Va for a first region obtained by multiplying a value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power by a predetermined percentage α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; a power profile Vb for a second region obtained by multiplying a value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less) and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; a power profile Vmid for an intermediate region having an average power smaller than the average power in the first region and larger than the average power in the second region; The intraocular lens has a power profile V that falls within a collection area of ​​power profiles obtained by combining the power profiles Va, Vmid, and Vb.

[0030] A seventeenth aspect is the intraocular lens according to the sixteenth aspect, wherein the absolute value of the average value of the tangent slope of the power profile Vmid in the intermediate region is greater than the absolute value of the average value of the tangent slope of the power profile V1 in the first region, and is smaller than the absolute value of the average value of the tangent slope of the power profile V2 in the second region.

[0031] An 18th aspect is the intraocular lens according to the 16th aspect, wherein, at each horizontal axis value of the power profile Vmid in the intermediate region, the average value of values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile Vmid is greater than the average value of values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile V1 at each horizontal axis value of the power profile V1 in the first region, and is greater than the average value of values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile V2 at each horizontal axis value of the power profile V2 in the second region.

[0032] A nineteenth aspect is the intraocular lens according to the sixteenth aspect, wherein the intermediate region has a horizontal axis value falling within a range of 1.3 mm or more and 2.5 mm or less.

[0033] A twentieth aspect is the intraocular lens according to the sixteenth aspect, wherein the maximum value rmax of the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0034] A twenty-first aspect is the intraocular lens according to the sixteenth aspect, wherein the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three times or more the absolute value of the average value of the tangent slope of the power profile V1 in the first region.

[0035] A 22nd aspect is an intraocular lens according to the 16th aspect, which comprises one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

[0036] A twenty-third aspect is the intraocular lens according to the sixteenth aspect, wherein the power profile V is expressed by a polynomial.

[0037] A 24th aspect is an intraocular lens according to the 16th aspect, which comprises one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting incident light beams onto the retina.

[0038] A 25th aspect is an intraocular lens having at least two adjacent regions for vision correction that are concentric with a lens center O having a predetermined base power set thereto, wherein the regions for vision correction are set in order from a first region including the lens center O toward the outside in the radial direction to a second region surrounding the first region, and when the power profile of a virtual aspherical lens that has a base power at the lens center O and cancels out all positive vertical spherical aberration caused by the cornea is set as an aspherical reference power profile W, when the horizontal axis (unit: mm) represents the position when viewed in the radial direction from the lens center O and the vertical axis (unit: D (diopter)) represents the total power profile when the refractive power of the cornea and the power of the intraocular lens are added together, and when the position of the first boundary between the first region and the second region when viewed in the radial direction from the lens center O is set as r1, a total power profile TVa for the first region obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference total power profile TW, to which the refractive power of the cornea has been added, from the base power, multiplying the result by a predetermined ratio α (α is 10% or more and 50% or less), and adding the result to the vertical axis value at each horizontal axis value of the aspherical reference total power profile TW; a total power profile TVb for the second region obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference total power profile TW, to which the refractive power of the cornea has been added, from the maximum value rmax of the horizontal axis of the aspherical reference total power profile TW, multiplying the result by a predetermined ratio β (β is 10% or more and 50% or less), and adding the result to the horizontal axis value at each vertical axis value of the aspherical reference total power profile TW; The intraocular lens has a total power profile TV that falls within the aggregate area of ​​the total power profiles obtained by combining the total power profiles TVa and TVb when the intersection of the above is positioned at position ra on the horizontal axis.

[0039] A 26th aspect is an intraocular lens according to the 25th aspect, in which in the total power profile TV1 for the first region, the vertical axis value continuously increases as the horizontal axis value increases, and in the total power profile TV2 for the second region, the vertical axis value continuously decreases as the horizontal axis value increases.

[0040] A 27th aspect is an intraocular lens according to the 25th aspect, wherein the absolute value of the average value of the tangent slope of the total power profile TV1 near the origin in the first region is smaller than the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region, the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region is larger than the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region, and the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region is smaller than the absolute value of the average value of the tangent slope of the total power profile TV2 near the intermediate position in the second region.

[0041] A 28th aspect is the intraocular lens according to the 25th aspect, wherein in the total power profile TV, the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at position r1 is the maximum positive value, and r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

[0042] A twenty-ninth aspect is the intraocular lens according to the twenty-fifth aspect, in which the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum value rmax of the horizontal axis of the total power profile TV is less than ±0.30D.

[0043] A thirtieth aspect is the intraocular lens according to the twenty-fifth aspect, wherein the maximum value rmax on the horizontal axis of the total power profile TV is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0044] A thirty-first aspect is an intraocular lens according to the twenty-fifth aspect, which comprises one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting incident light beams onto the retina.

[0045] A 32nd aspect is an intraocular lens having at least two adjacent regions for vision correction that are concentric with a lens center O having a predetermined base power set thereto, wherein the regions for vision correction are set as second regions surrounding the first region, in order from a first region including the lens center O toward the radially outward direction, and wherein in a power profile in which the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)) represents the power, the aspherical reference power profile W is a power profile of a virtual aspherical lens that has a base power at the lens center O and that completely cancels out the positive vertical spherical aberration caused by the cornea, and the power profile Va for the first region is a power profile obtained by multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power by a predetermined ratio α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W, When the power profile Vb for the second region is obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W and multiplying the result by a predetermined percentage β (β is 10% or more and 50% or less), and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W, the first region comprises an inner first region having a power profile in which a positive power is added to the power profile Va for the first region, the second region comprises the power profile Vb, and the area of ​​the inner first region is less than 50% of the total area of ​​the first region.

[0046] A 33rd aspect is the intraocular lens according to the 32nd aspect, in which the first region, when viewed radially from the lens center O, comprises an inner first region and an outer first region surrounding the inner first region, and the outer first region has a power profile Va and is in contact with the second region at the intersection of the power profiles Va and Vb.

[0047] A thirty-fourth aspect is the intraocular lens according to the thirty-second aspect, wherein the lens body of the intraocular lens has two opposing surfaces and the inner first region is provided on the anterior surface, the posterior surface, or both.

[0048] A thirty-fifth aspect is the intraocular lens according to the thirty-second aspect, wherein the first region includes a region other than the inner first region whose average power is equal to the average power of the power profile Va, and the average power of the inner first region is 0.75 to 4.0 D larger than the average power of the region other than the inner first region.

[0049] A thirty-sixth aspect is the intraocular lens according to the thirty-third aspect, wherein the first region comprises an outer transition region for connecting the inner first region to the outer first region.

[0050] A thirty-seventh aspect is the intraocular lens according to the thirty-second aspect, wherein the inner first region comprises a constant power addition region having a power profile in which a positive constant power is added to the power profile Va for the first region, and when viewed radially from the lens center O, the radial distance of the constant power addition region is 33 to 67% of the radial distance of the inner first region.

[0051] A thirty-eighth aspect is the intraocular lens according to the thirty-second aspect, wherein the inner first region includes the lens center O.

[0052] A thirty-ninth aspect is the intraocular lens of the thirty-third aspect, wherein the first region includes an innermost region having a power profile Va for the first region and including the lens center O, and the inner first region surrounds the innermost region.

[0053] A fortieth aspect is the intraocular lens according to the thirty-ninth aspect, wherein the first region comprises an inner transition region for connecting the inner first region to the innermost region.

[0054] A forty-first aspect is the intraocular lens according to the thirty-second aspect, wherein the front surface, the rear surface, or both of the lens body of the intraocular lens having two opposing surfaces are aspherical.

[0055] A forty-second aspect is an intraocular lens according to the thirty-second aspect, wherein the front surface, the rear surface, or both of the lens body of the intraocular lens having two opposing surfaces are provided with a toric surface having a cylindrical power for correcting astigmatism in an aphakic patient.

[0056] The lens surface that is turned (formed) into an aspheric surface to achieve (create) the power profile taught by the disclosure of the present application (the present specification) may be the front surface only, the back surface only, or both the front and back surfaces (both surfaces).

[0057] A forty-third aspect is the intraocular lens according to any one of the first to forty-second aspects, which is made of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, PMMA copolymer, and collagen-containing copolymer of HEMA (hydroxyethyl methacrylate).

[0058] A forty-fourth aspect is a method for designing an intraocular lens, for designing the intraocular lens according to any one of the first to forty-second aspects.

[0059] A forty-fifth aspect is a method for manufacturing an intraocular lens, in which an intraocular lens designed by the method for designing an intraocular lens according to the forty-fourth aspect is manufactured by at least one of lathing, molding, and 3D printing.

[0060] Other aspects of the present invention are listed below.

[0061] The area ratio between the first region and the second region in a plan view may be set to a range of 25:75 to 75:25.

[0062] In the first region, the power preferably decreases continuously, and in the second region, the power preferably decreases continuously.

[0063] Between the lens center O and the position r1 of the first boundary, it is preferable that the total power T obtained by adding the refractive power of the cornea and the power of the intraocular lens increases continuously.

[0064] The technical concept of the present invention can also be applied to a method for designing or manufacturing an intraocular lens.

[0065] According to the present invention, the image quality remains good and is robust against changes in the image quality with respect to the above-mentioned displacement, tilt, and pupil diameter.

[0066] Fig. 1 is a schematic plan view of an intraocular lens according to an embodiment of the present invention. Fig. 2 is a power profile in which the horizontal axis (unit: mm) represents the position as viewed radially from the lens center O, and the vertical axis represents the power (unit: D (diopter)). Fig. 3 is a power profile showing the refractive power (vertical axis) provided by the optical portion of the intraocular lens versus the distance (horizontal axis) from the lens center O, and shows a power profile Va obtained by adding the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power, multiplying the result by a predetermined percentage α (α is 10% or more, i.e., I10, 35% or I35, and 50% or I50, among values ​​between 10% and 50%) to the vertical axis value at each horizontal axis value of the aspherical reference power profile W. Fig. 4 is a power profile showing the refractive power (vertical axis) provided by the optical portion of the intraocular lens versus the distance from the lens center O (horizontal axis), and shows a power profile Vb obtained by adding the value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less, i.e., O10, 25% or O25, and 50% or O50) to the horizontal axis value at each vertical axis value of the aspherical reference power profile W. Fig. 5 is an explanatory diagram when I35 in Fig. 3 and O25 in Fig. 4 are superimposed. Fig. 6 is a diagram showing a power profile V obtained by splicing together the power profile Va (I35) for the first region and the power profile Vb (O25) for the second region in Fig. 5. FIG. 7 shows I10-O10, I40-O20, and I50-O50. FIG. 8 shows the area (hatched portion) formed by the power profile when the intersection of the power profile Va for the first region (α is 10% or more and 50% or less) and the power profile Vb for the second region (β is 10% or more and 50% or less) is positioned ra on the horizontal axis. FIG. 9 shows the power profile V (solid line) in the [Other] embodiment of the present invention, where different power profiles are not directly patched together, but a profile that imitates the patched-up profile is used. FIG. 10 shows the power profile V (solid line, I35-O25, optical zone diameter 6.50 mm) when an additional region is provided.FIG. 11 shows I10-O10 and I50-O50, and for each power profile V, the average value of the tangent slope of the power profile V1 in the first region and the absolute value of the average value of the tangent slope of the power profile V2 in the second region are also shown. FIG. 12A shows the power profile V (solid line, I35-O25) when an intermediate region is provided. FIG. 12B shows the intermediate region of FIG. 12A when it is expanded. FIG. 12C shows the power profile V (solid line, I40-O40) when an intermediate region is provided. FIG. 13 is a table showing the conditions adopted for the total power profile according to an embodiment of the present invention. FIG. 14 shows the total power profile TV, which shows the total power T (vertical axis) when the refractive power of the cornea and the power of the intraocular lens are combined, versus the distance from the lens center O (horizontal axis). Fig. 15 shows the total power profile TV when the horizontal axis value rmax of 3.0 mm is matched with the vertical axis value when the horizontal axis value is zero. Fig. 16 shows the region (hatched portion) formed by the total power profile when the intersection of the total power profile TVa for the first region (α is 10% or more and 50% or less) and the total power profile TVb for the second region (β is 10% or more and 50% or less) is set as the horizontal axis position ra. Fig. 17A is a plot showing the MTF value (vertical axis) indicating contrast versus the object distance (distance) from the corneal apex (horizontal axis) (aperture diameter (pupil diameter) is set to 3.0 mm, and there is no displacement or tilt). The MTF values ​​shown in Figs. 17 to 30 are MTF values ​​when the spatial frequency is 100 lines / mm. The spatial frequency of the MTF value (vertical axis) is 100 lines / mm. Fig. 17B is a diagram of Fig. 17A with the aperture diameter set to 3.5 mm. Fig. 17C is a diagram of Fig. 17A with the aperture diameter set to 4.0 mm. Fig. 17D is a diagram of Fig. 17A with the aperture diameter set to 4.5 mm. Fig. 18A is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 mm, displacement 0.3 mm, no tilt). Fig. 18B is a diagram of Fig. 18A with the aperture diameter set to 3.5 mm.Fig. 18C is a diagram of Fig. 18A with the aperture diameter set to 4.0 mm. Fig. 18D is a diagram of Fig. 18A with the aperture diameter set to 4.5 mm. Fig. 19A is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 mm, displacement is 0.5 mm, and there is no tilt). Fig. 19B is a diagram of Fig. 19A with the aperture diameter set to 3.5 mm. Fig. 19C is a diagram of Fig. 19A with the aperture diameter set to 4.0 mm. Fig. 19D is a diagram of Fig. 19A with the aperture diameter set to 4.5 mm. 20A is a plot showing the MTF value (vertical axis) indicating contrast versus the object distance (distance) from the corneal apex (horizontal axis) (aperture diameter (pupil diameter) is set to 3.0 mm, there is no displacement, and the slope is 3 degrees). FIG. 20B is a diagram of FIG. 20A with the aperture diameter set to 3.5 mm. FIG. 20C is a diagram of FIG. 20A with the aperture diameter set to 4.0 mm. FIG. 20D is a diagram of FIG. 20A with the aperture diameter set to 4.5 mm. FIG. 21A is a plot showing the MTF value (vertical axis) indicating contrast versus the object distance (distance) from the corneal apex (horizontal axis) (aperture diameter (pupil diameter) is set to 3.0 mm, there is no displacement, and the slope is 5 degrees). FIG. 21B is a diagram of FIG. 21A with the aperture diameter set to 3.5 mm. Fig. 21C is a diagram of Fig. 21A with the aperture diameter set to 4.0 mm. Fig. 21D is a diagram of Fig. 21A with the aperture diameter set to 4.5 mm. Fig. 22A is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 mm, displacement is 0.3 mm, and tilt is 3 degrees). Fig. 22B is a diagram of Fig. 22A with the aperture diameter set to 3.5 mm. Fig. 22C is a diagram of Fig. 22A with the aperture diameter set to 4.0 mm. Fig. 22D is a diagram of Fig. 22A with the aperture diameter set to 4.5 mm.23A is a plot showing the MTF value (vertical axis) indicating contrast versus the object distance (distance) from the corneal apex (horizontal axis) (aperture diameter (pupil diameter) is set to 3.0 mm, displacement is 0.4 mm, and tilt is 4 degrees). FIG. 23B is a diagram of FIG. 23A with the aperture diameter set to 3.5 mm. FIG. 23C is a diagram of FIG. 23A with the aperture diameter set to 4.0 mm. FIG. 23D is a diagram of FIG. 23A with the aperture diameter set to 4.5 mm. FIG. 24A is a plot showing the MTF value (vertical axis) indicating contrast versus the object distance (distance) from the corneal apex (horizontal axis) (aperture diameter (pupil diameter) is set to 3.0 mm, displacement is 0.5 mm, and tilt is 5 degrees). FIG. 24B is a diagram of FIG. 24A with the aperture diameter set to 3.5 mm. FIG. 24C is a diagram of FIG. 24A with the aperture diameter set to 4.0 mm. FIG. 24D is a diagram of FIG. 24A with the aperture diameter set to 4.5 mm. FIG. 25A is a plot showing the MTF value (vertical axis) indicating contrast against the displacement (horizontal axis) (object distance set to 2.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no tilt). FIG. 25B is a diagram of FIG. 25A with the tilt set to 3 degrees. FIG. 25C is a diagram of FIG. 25A with the tilt set to 5 degrees. FIG. 25D is a diagram of FIG. 25A with the aperture diameter set to 4.0 mm and no tilt. FIG. 25E is a diagram of FIG. 25A with the aperture diameter set to 4.0 mm and the tilt set to 3 degrees. FIG. 25F is a diagram of FIG. 25A with the aperture diameter set to 4.0 mm and the tilt set to 5 degrees. Fig. 26A is a plot showing MTF values ​​(vertical axis) indicating contrast against displacement (horizontal axis) (object distance set to 3.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no tilt). Fig. 26B is a diagram of Fig. 26A with the tilt set to 3 degrees. Fig. 26C is a diagram of Fig. 26A with the tilt set to 5 degrees. Fig. 26D is a diagram of Fig. 26A with the aperture diameter set to 4.0 mm and no tilt. Fig. 26E is a diagram of Fig. 26A with the aperture diameter set to 4.0 mm and the tilt set to 3 degrees.FIG. 26F is a diagram of FIG. 26A with the aperture diameter set to 4.0 mm and the tilt set to 5 degrees. FIG. 27A is a plot showing the MTF value (vertical axis) indicating contrast against the displacement (horizontal axis) (object distance set to 4.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no tilt). FIG. 27B is a diagram of FIG. 27A with the tilt set to 3 degrees. FIG. 27C is a diagram of FIG. 27A with the tilt set to 5 degrees. FIG. 27D is a diagram of FIG. 27A with the aperture diameter set to 4.0 mm and no tilt. FIG. 27E is a diagram of FIG. 27A with the aperture diameter set to 4.0 mm and the tilt set to 3 degrees. FIG. 27F is a diagram of FIG. 27A with the aperture diameter set to 4.0 mm and the tilt set to 5 degrees. FIG. 28A is a plot showing the MTF value (vertical axis) indicating contrast against the tilt (horizontal axis) (object distance set to 2.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no displacement). FIG. 28B is a diagram of FIG. 28A with the displacement set to 0.3 mm. FIG. 28C is a diagram of FIG. 28A with the displacement set to 0.5 mm. FIG. 28D is a diagram of FIG. 28A with the aperture diameter set to 4.0 mm and no displacement. FIG. 28E is a diagram of FIG. 28A with the aperture diameter set to 4.0 mm and the displacement set to 0.3 mm. FIG. 28F is a diagram of FIG. 28A with the aperture diameter set to 4.0 mm and the displacement set to 0.5 mm. FIG. 29A is a plot showing MTF values ​​(vertical axis) indicating contrast against tilt (horizontal axis) (object distance set to 3.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no displacement). FIG. 29B is a diagram of FIG. 29A with the displacement set to 0.3 mm. FIG. 29C is a diagram of FIG. 29A with the displacement set to 0.5 mm. FIG. 29D is a diagram of FIG. 29A with the aperture diameter set to 4.0 mm and no displacement. FIG. 29E is a diagram of FIG. 29A with the aperture diameter set to 4.0 mm and the displacement set to 0.3 mm. FIG. 29F is a diagram of FIG. 29A with the aperture diameter set to 4.0 mm and the displacement set to 0.5 mm.FIG. 30A is a plot showing the MTF value (vertical axis) indicating contrast against the tilt (horizontal axis) (object distance set to 4.0 m, aperture diameter (pupil diameter) set to 3.0 mm, and no displacement). FIG. 30B is a diagram of FIG. 30A with the displacement set to 0.3 mm. FIG. 30C is a diagram of FIG. 30A with the displacement set to 0.5 mm. FIG. 30D is a diagram of FIG. 30A with the aperture diameter set to 4.0 mm and no displacement. FIG. 30E is a diagram of FIG. 30A with the aperture diameter set to 4.0 mm and the displacement set to 0.3 mm. FIG. 30F is a diagram of FIG. 30A with the aperture diameter set to 4.0 mm and the displacement set to 0.5 mm. FIG. 31A is a planar schematic diagram showing an intraocular lens of embodiment 5A of the present invention. FIG. 31B is a planar schematic diagram showing an intraocular lens of embodiment 5B of the present invention. Fig. 32A is a power profile of an intraocular lens according to embodiment 5A of the present invention, in which the horizontal axis represents the position (unit: mm) when viewed in the radial direction from the lens center O, and the vertical axis represents the power (unit: D (diopter)). Fig. 32B is a power profile of an intraocular lens according to embodiment 5B of the present invention, in which the horizontal axis represents the position (unit: mm) when viewed in the radial direction from the lens center O, and the vertical axis represents the power (unit: D (diopter)). Fig. 33A is a diagram showing a planar schematic diagram (top) of an intraocular lens according to embodiment 5A of the present invention that includes an outer transition region, and a power profile (bottom) in which the horizontal axis represents the position (unit: mm) when viewed in the radial direction from the lens center O, and the vertical axis represents the power (unit: D (diopter)). Figure 33B is a schematic plan view (top) of an intraocular lens according to embodiment 5B of the present invention that includes an inner transition region in addition to an outer transition region, and a power profile (bottom) in which the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)). Figure 34 is a power profile in the intraocular lens according to embodiment 5A of the present invention, in which the horizontal axis (unit: mm) represents the position when viewed radially from the lens center O and the vertical axis (unit: D (diopter)), and explains the ratio of the radial distance of the fixed power added region to the radial distance of the inner first region.

[0067] [Definitions, etc.] Note that for configurations not described below, known configurations may be appropriately adopted. In particular, the contents (especially the haptics) described in a document (WO 2009 / 153873) disclosed by the present inventor may be applied to this embodiment. Furthermore, in this specification, the symbol "to" indicates a value greater than or equal to a predetermined value and less than or equal to a predetermined value. Furthermore, the lens body of the intraocular lens discussed in this specification has two opposing surfaces. The surface of the lens body that contacts the posterior capsule when the intraocular lens is inserted into the lens capsule can be referred to as the posterior surface, the retina-side surface, or the retina-side surface in the optical axis direction, but the term "posterior surface" will be primarily used in this specification. The other surface can be referred to as the anterior surface, the cornea-side surface, or the cornea-side surface in the optical axis direction, but the term "anterior surface" will be primarily used in this specification. The optical axis direction is also the lens thickness direction, and refers to the direction from the posterior surface to the anterior surface or the reverse direction. The optical axis direction is the z-axis direction.

[0068] The lens center O refers to the geometric center or optical center of the intraocular lens. In this specification, the case where the geometric center and the optical center coincide is illustrated. The refractive power at this lens center O is referred to as the base power. This base power refers to the refractive power required for distance vision in conventional intraocular lenses.

[0069] [Common Embodiment] Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. First, the common content and common inventive concept of the first and subsequent embodiments will be described as a common embodiment.

[0070] FIG. 1 is a schematic plan view showing an intraocular lens according to a common embodiment.

[0071] As shown in FIG. 1 , an intraocular lens according to a common embodiment (and other aspects described herein) comprises, like a conventional intraocular lens, a lens body having a lens function and a support portion that supports the lens body within the lens capsule.

[0072] The material of the intraocular lens is not limited, and may be made of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, PMMA copolymer, and copolymer of HEMA (hydroxyethyl methacrylate) containing collagen (e.g., Collamer (registered trademark)).

[0073] As shown in Figure 1, in the common embodiment (and other aspects described herein), the entire lens body is an optical part having a lens function, where "lens function" refers to the function of refracting incident light onto the retina.

[0074] In this specification, the entire lens body is exemplified as consisting of a first region (zone 1) and a second region (zone 2) described below. In other aspects described in this specification, an intermediate region surrounding the first region is provided between the first region and the second region, or an additional region surrounding the second region is provided radially outward of the second region.

[0075] In a common embodiment, the intraocular lens is defined by the refractive power (power, dioptric power) relative to the distance in the radial direction from the lens center O. In this specification, the "direction radially away from the lens center O" is defined as the "outside."

[0076] An aspect of an intraocular lens according to a common embodiment (and other aspects described herein) first includes at least two adjacent vision correction regions that are concentric with a lens center O and have a predetermined base power set thereto. The vision correction regions are set in order from a first region that includes the lens center O toward the outside in the radial direction to a second region that surrounds the first region. The position of a first boundary (boundary 1) between the first region and the second region when viewed in the radial direction from the lens center O is set to r1.

[0077] As shown in Figure 1, in a plan view, the first region is circular and the second region is annular. In other aspects described herein, the intermediate region is a small annular ring, and the additional region is a large annular ring. Note that instead of a circular and / or annular shape, an elliptical and / or an elliptical annular shape may be used. In the case of an ellipse, the position r1 of the first boundary may be determined by the major axis or minor axis.

[0078] FIG. 2 shows a power profile in which the horizontal axis (unit: mm) represents the position in the radial direction from the lens center O, and the vertical axis represents the power (unit: D (diopter)). The distance from the lens center O is also referred to as the radius. The solid line represents the power profile of an intraocular lens according to a common embodiment (and other aspects described herein). The dotted line represents the power profile of a virtual spherical lens (also referred to herein as a "spherical IOL") having a base power (dashed line) at the lens center O. Note that intraocular lenses with a constant power regardless of the value of the radius (the horizontal axis) are well known (e.g., SofPort (registered trademark) AO IOL). In this specification, this type of intraocular lens is also referred to as a "zero-aberration IOL." However, unlike the aspherical reference power profile W described below, the zero-aberration IOL does not take the cornea into consideration. In other words, the power profile of a zero-aberration IOL does not take into account the positive vertical spherical aberration or refractive power caused by the cornea. The dashed-dotted line represents the power profile of a hypothetical aspherical lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea. This power profile is also referred to as the aspherical reference power profile W.

[0079] Longitudinal spherical aberration is spherical aberration in a direction extending radially from the lens center O, that is, in a radial direction (meridional). In this case, spherical aberration in a circumferential direction (sagittal) perpendicular to the radial direction is horizontal spherical aberration.

[0080] The cornea has positive refractive power. Spherical aberration increases with distance from the center of the cornea. In other words, the dashed-dotted line representing the aspherical reference power profile W is a plot of a hypothetical aspherical lens that theoretically cancels out all of the positive vertical spherical aberration caused by the cornea. Hereinafter, the various lines will have the same meaning.

[0081] An aspheric optically designed IOL having an aspheric reference power profile W is designed to correct or reduce all or part of the corneal spherical aberration. The degree to which the corneal spherical aberration is reduced varies for each IOL from each company. Each company's IOL is designed to reduce the corneal spherical aberration by a specific amount (value). In designing the aspheric IOL, a corneal model having a spherical aberration value equal to the specific amount of spherical aberration to be reduced is preset, and the specific amount of spherical aberration to be reduced by the aspheric IOL is determined by selecting the optical parameters of the corneal model. During the optical design process, the total spherical aberration of the optical system (optical system) consisting of the predetermined corneal model and the designed aspheric IOL is zero (i.e., there is no spherical aberration).

[0082] The spherical aberration value of the given corneal model is determined as follows: The spherical aberration value of the given corneal model used in the optical design of the aspherical IOL is assumed to be the same as the mean value of the spherical aberration for a population of eye patients wearing the IOL, or the spherical aberration value of the given corneal model is determined by setting the spherical aberration value to a value that partially reduces the corneal spherical aberration of the population of eye patients.

[0083] The aspheric reference power profile W is the power distribution of an aspheric IOL. This power distribution has power distribution characteristics that enable complete or partial reduction of the spherical aberration of the average cornea (statistical corneal optical parameters) of a population of aphakic patients. In this specification, the spherical aberration value of a predetermined corneal model is set to 0.27 μm. Figure 2 is also an example of the power distribution of an aspheric IOL that can completely reduce the spherical aberration of a corneal model with a spherical aberration value of 0.27 μm. 0.27 μm may also be expressed as +0.27 μm. Furthermore, the present invention is not strictly limited to 0.27 μm, and may be, for example, a value in the range of +0.24 to +0.30 μm.

[0084] The following describes the inventive concept common to the first and subsequent embodiments.

[0085] To reiterate, an object of the present invention is to provide an intraocular lens and related technology that are robust in terms of changes in image quality against the above-mentioned changes in displacement, tilt, and pupil diameter (hereinafter collectively referred to as "each change"). "Robust" here also means being less susceptible to influence or insensitive.

[0086] While the aspheric IOL can correct or reduce all or part of the corneal spherical aberration and still meet prescription values, image quality is sensitive to these changes.

[0087] The spherical IOL is more robust to changes in image quality than the aspherical IOL. However, when the changes are absent, the image quality of the spherical IOL is inferior to that of the aspherical IOL. In particular, when the pupil diameter increases, the difference in image quality becomes more pronounced.

[0088] The zero-aberration IOL is more robust to changes in image quality than an aspherical IOL. However, the power profile of a zero-aberration IOL does not take into account the positive vertical spherical aberration or refractive power caused by the cornea. As a result, in the absence of the changes, the image quality of a zero-aberration IOL is slightly better than that of a spherical IOL, but is inferior to that of an aspherical IOL.

[0089] In the present invention, first, the aspherical reference power profile W of the aspherical IOL is taken as a whole as a reference. In the aspherical reference power profile W, as the horizontal axis value, which is the radial direction from the lens center O, increases, the vertical axis value, which is the power, decreases.

[0090] Here, the aspherical reference power profile W is divided into at least two regions. The side closer to the lens center O is the first region, and the outside of that is the second region. Then, the aspherical reference power profile W is deformed in each region.

[0091] In the first region, even if the horizontal axis value increases, the degree of decrease in the vertical axis value is made gentler than in the aspherical reference power profile W. To compensate for this, in the second region, when the horizontal axis value increases, the degree of decrease in the vertical axis value is made steeper than in the aspherical reference power profile W.

[0092] As shown in the data below, an intraocular lens that adopts a power profile that is a modified version of the aspherical reference power profile W based on this concept will maintain image quality as good as that of an aspherical IOL, while being robust to changes in image quality caused by the above-mentioned changes.

[0093] In other words, the concept of the present invention is to patch together two or more different power profiles rather than a single power profile like the aspherical reference power profile W. The concept of the present invention is that when this patching is performed, the first region has a gentler rate of decrease in the vertical axis value than the aspherical reference power profile W when viewed as a whole, while the second region has a steeper rate of decrease in the vertical axis value than the aspherical reference power profile W when viewed as a whole.

[0094] The concept of the present invention also has the advantage of allowing for a reduced thickness of the intraocular lens. For example, the central thicknesses of a spherical IOL, a zero-aberration IOL, an aspherical IOL, and an IOL based on the concept of the present invention (see Figure 2 below) were measured under the following parameters. These parameters are also referred to as Condition 1. The negative radius of curvature of the posterior surface is due to the fact that the anterior surface is convex and the direction of curvature of this convexity is positive. Lens optical diameter: 6 mm Refractive index at 35°C: 1.520 Thickness of the outermost edge of the lens body: 0.18 mm Radius of curvature of the posterior surface: -20.0 mm The results are as follows: Spherical IOL: 0.674 mm Zero-aberration IOL: 0.669 mm Aspherical IOL: 0.626 mm IOL based on the concept of the present invention: 0.632 mm In other words, the thickness of the IOL based on the concept of the present invention can be reduced. This makes it easier to fold the intraocular lens and subsequently restore it within the eye. Furthermore, the wound during the procedure can be made smaller.

[0095] The following embodiments 1 to 4 are specific aspects based on the above concept. Embodiment 1 is an aspect based on the above concept, in which the range in which the power profile V of the intraocular lens falls is expressed by the deformation range of the aspherical reference power profile W in the first region and the deformation range of the aspherical reference power profile W in the second region. Embodiment 2 is an aspect in which the above concept is expressed by an increase or decrease in the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profiles V1 and V2. Embodiment 3 is an aspect in which an intermediate region is provided between the first and second regions in Embodiment 1. Embodiment 4 is an aspect in which the power profile in Embodiment 1 is converted into a total power profile by adding the refractive power of the cornea. The intraocular lenses according to the following embodiments 1 to 4 are aspherical intraocular lenses. The surface of the intraocular lens that is turned (formed) into an aspheric surface to achieve (create) the power profile taught by the disclosed content (the present specification) of this application may be only the front surface, only the back surface, or both the front and back surfaces (both surfaces).

[0096] [Embodiment 1] An intraocular lens according to embodiment 1 is as follows. Embodiments 1 and subsequent embodiments can be arbitrarily combined with each other and each of the other embodiments (including common embodiments). Furthermore, the content of embodiment 1 can be used in conjunction with each of the other embodiments (including common embodiments). "An intraocular lens comprising: a power profile Va for a first region obtained by multiplying a value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power, by a predetermined percentage α (α is 10% or more and 50% or less), and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; and a power profile Vb for a second region obtained by multiplying a value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W, by a predetermined percentage β (β is 10% or more and 50% or less), and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; and a power profile V that falls within a collective region of power profiles obtained by combinations of the power profiles Va and Vb, when the intersection of the above is set to position ra on the horizontal axis."

[0097] The "area (hereinafter also referred to as the 'aggregate area') formed by the power profiles when the intersection of the power profile Va for the first area and the power profile Vb for the second area is at position ra on the horizontal axis" refers to the hatched portion in FIG. 8. The power profile Va and the power profile Vb intersect. In the negative direction of the horizontal axis from this intersection (position ra on the horizontal axis), the power profile Va is adopted for the first area. In the positive direction of the horizontal axis from this intersection (position ra on the horizontal axis), the power profile Vb is adopted for the second area. The hatched portion in FIG. 8 is the aggregate area of ​​the power profiles obtained by the combinations of α being 10% or more and 50% or less, and β being 10% or more and 50% or less.

[0098] The maximum value rmax on the horizontal axis of the aspherical reference power profile W means the outermost edge of the lens body, that is, the optical part having a lens function.

[0099] The above-mentioned content regarding "multiplying by predetermined ratios α and β" may be expressed as follows: "An intraocular lens comprising: a power profile Va for a first region obtained by reducing the aspherical reference power profile W by a constant magnification α (α is 10% or more and 50% or less) from the negative direction of the vertical axis to the positive direction of the vertical axis (leaving the portion of the vertical axis value (base power) when the horizontal axis value is zero unchanged); and a power profile Vb for a second region obtained by reducing the aspherical reference power profile W by a constant magnification β (β is 10% or more and 50% or less) from the negative direction of the horizontal axis (leaving the portion of the horizontal axis value rmax unchanged); and a power profile V that falls within a collective region of power profiles obtained by combinations of the power profiles Va and Vb when the intersection of the above is set to position ra on the horizontal axis."

[0100] For example, r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

[0101] For example, at each horizontal axis value of the power profile V, the position r1 is the maximum positive value among the values ​​obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V. Position r1 is also the point where different power profiles are patched together.

[0102] For example, the maximum value rmax on the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less. Hereinafter, unless otherwise specified, the case where rmax is 3.0 mm will be exemplified.

[0103] The intraocular lens according to this embodiment may include one or more additional regions radially extending from the second region. The additional regions surround the second region. The additional regions preferably have a function of refracting incident light beams onto the retina, and preferably have a function equivalent to that of an optical zone.

[0104] At each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile Vadd may be less than ±0.30 D (preferably less than ±0.15 D, and the same applies hereinafter). In other words, the deviation of the vertical axis of at least one of the additional regions outside the second region (preferably the outermost additional region or the only additional region) from the aspherical reference power profile W may be less than ±0.30 D, whether the region matches or does not match.

[0105] As mentioned above, aspheric IOLs have good image quality when the above-mentioned changes are absent. The effect of robust image quality against the above-mentioned changes is largely achieved in the first and second regions. As a result, even if an additional region is provided outside the second region, it is preferable to adopt a power profile that closely resembles the aspheric reference power profile W as much as possible. Deviation from the plot of the aspheric reference power means the occurrence of vertical spherical aberration, which ultimately leads to a lack of vision correction. To avoid this, it is preferable to adopt a power profile that closely resembles the aspheric reference power profile W as much as possible.

[0106] The power profile V may be expressed by a polynomial. For example, the power profiles of the first region, the second region, the intermediate region, and the additional region can be expressed by the following polynomial: P(r) = a n r n + a n-1 r n-1 + a n-2 r n-2 + a n-3 r n-3 + . . . + a3r 3 + a2r 2 + a1r 1 + a0 ... (Equation 1) P(r): Power at lens radial position a: Coefficient r: Lens radial position n: Polynomial order

[0107] The following polynomials are polynomials in each region when the position r1 is set to 1.92 mm, the horizontal axis value is set to 3.00 mm as the boundary position between the second region and the additional region (only one), and rmax is set to 3.25 mm (see FIG. 10). Ｉ３５ I35 in the figure indicates that the predetermined ratio α in the power profile Va is 35% (for example, when α is 10%, it is written as Va(I10) as shown in FIG. 2), and P Ｏ２５ In the figure, O25 indicates that the predetermined percentage β in the power profile Vb is 25% (for example, when β is 10% as shown in FIG. 2, it is written as Vb(O10)). I35 (r)=-2.87802590e-03r 4 -4.84408818e-04r 3 -2.39306469e-01r 2 -1.30725682e-04r+20.000009 Second area: P O25 (r)=-4.38903190e-04r 4 -7.72003537e-02r 3 -3.13958521e-01r 2 +4.43293306e-01r+19.934990 Additional area: P add (r)=1.75786855r 4 -2.21096892e+01r 3 +1.03671760e+02r 2 -2.17611350e+02r+190.681131

[0108] In this embodiment, when viewed in FIG. Ｉ５０ and P Ｏ５０ The horizontal axis value of the intersection with rah, P Ｏ１０ and P Ｉ１０ The horizontal axis value of the intersection with is ral. In other words, when viewed in FIG. 2, in clockwise order, Ｉ５０ and, rah and, P Ｏ５０ And, P Ｏ１０ and,ral and,P Ｉ１０ The power profile V is contained in the area surrounded by (the hatched portion in FIG. 8).

[0109] However, the present invention is not limited to the power profile V falling within the above region (the hatched portion in FIG. 8 ). For example, even if the vertical axis value of the power profile V is slightly lower than the aspheric reference power profile W when the horizontal axis value is zero or a value close to rmax, there is little effect on the optical performance of the intraocular lens (IOL), and the image quality remains robust against the above-mentioned changes. Taking this into consideration, the following embodiment 2 is a specification that strongly reflects the concept of the above invention.

[0110] [Embodiment 2] The intraocular lens according to embodiment 2 is as follows: "In the first region, the average value of the vertical axis values ​​of the power profile V1 for the first region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W; In the second region, the average value of the vertical axis values ​​of the power profile V2 for the second region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W; In the power profile V1 for the first region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V1 at each horizontal axis value increases continuously; In the power profile V2 for the second region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2 at each horizontal axis value decreases continuously; In the power profile V, the position r1 is the maximum positive value among the values ​​obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2; An intraocular lens in which the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value at the maximum value rmax of the horizontal axis of the power profile V is less than 0.25D.

[0111] For example, the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three times or more the absolute value of the average value of the tangent slope of the power profile V1 in the first region. In other words, in the power profile V of the intraocular lens according to this embodiment, power profiles having such different absolute values ​​of the average value of the tangent slope are joined together at position r1.

[0112] The meaning of "in the first region, the average value of the vertical axis values ​​of the power profile V1 for the first region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W" is as follows: It means that the average power in the first region of the intraocular lens according to this embodiment is greater than the average power of the aspherical reference power profile W in the first region. Similarly, "in the second region, the average value of the vertical axis values ​​of the power profile V2 for the second region is greater than the average value of the aspherical reference power profile W" means that the average power in the second region of the intraocular lens according to this embodiment is greater than the average power of the aspherical reference power profile W in the second region.

[0113] Note that "the subtracted value in the first region continuously increases" and "the subtracted value in the second region continuously decreases" are preferred examples and can be excluded from the definition. Even if there is a small portion in the first region or the second region that does not satisfy these requirements, the effect of the present invention will be negligible.

[0114] Furthermore, of the above configuration of the intraocular lens according to embodiment 2, the following provisions may be adopted as the provisions for the intraocular lens according to embodiment 2: "In the first region, the average value of the vertical axis values ​​of the power profile V1 for the first region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W, and in the second region, the average value of the vertical axis values ​​of the power profile V2 for the second region is greater than the average value of the vertical axis values ​​of the aspherical reference power profile W," as well as "The absolute value of the average value of the tangent slope of the power profile V2 in the second region is greater than the absolute value of the average value of the tangent slope of the power profile V1 in the first region," "In the power profile V, the position r1 is the position where the positive maximum value is obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2," and "r1 is a value within the range of 1.5 mm or more and 2.3 mm or less."

[0115] For example, r1 is a value within the range of 1.5 mm or more and 2.3 mm or less. Also, the maximum value rmax on the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0116] The following definition adopted in embodiment 1 may be applied to this embodiment: "The present embodiment comprises a power profile Va for a first region obtained by adding a value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power, multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W by a predetermined percentage α (α is 10% or more and 50% or less), to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; and a power profile Vb for a second region obtained by adding a value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W, multiplying the value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less), to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; and a power profile V that falls within a collection region of power profiles obtained by combinations of the power profiles Va and Vb when the intersection of the above is set to the position ra on the horizontal axis."

[0117] One or more additional regions may be provided radially outward from the second region, the additional regions may surround the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile Vadd may be less than ±0.30 D. The additional region may have a function of refracting an incident light beam onto the retina.

[0118] The power profile V may be expressed by the above polynomial.

[0119] [Embodiment 3] The intraocular lens according to embodiment 3 is as follows: "A power profile Va for a first region obtained by multiplying a value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power by a predetermined percentage α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W; A power profile Vb for a second region obtained by multiplying a value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less) and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W; A power profile Vmid for an intermediate region having an average power smaller than the average power in the first region and larger than the average power in the second region; An intraocular lens having a power profile V that falls within a collection area of ​​power profiles obtained by combining each of the power profiles Va, Vmid, and Vb, which is configured as follows:

[0120] In this embodiment, the intermediate region has a role of connecting the first region and the second region. The intermediate region may also serve as a transition region that smoothly connects the first region and the second region in the vertical axis value. In other words, in this embodiment, when patching together different power profiles, the power profiles are not patched together directly, but rather, three power profiles are patched together with another power profile sandwiched between them.

[0121] For example, the absolute value of the average value of the tangent slope of the power profile Vmid in the intermediate region is greater than the absolute value of the average value of the tangent slope of the power profile V1 in the first region, and is smaller than the absolute value of the average value of the tangent slope of the power profile V2 in the second region.

[0122] For example, at each horizontal axis value of the power profile Vmid in the intermediate region, the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile Vmid is greater than the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile V1 at each horizontal axis value of the power profile V1 in the first region, and is greater than the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspherical reference power profile W from the vertical axis values ​​of the power profile V2 at each horizontal axis value of the power profile V2 in the second region.

[0123] For example, the intermediate region is within the range of the horizontal axis value of 1.3 mm or more and 2.5 mm or less.

[0124] For example, the maximum value rmax on the horizontal axis of the power profile V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0125] For example, the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three times or more the absolute value of the average value of the tangent slope of the power profile V1 in the first region.

[0126] For example, one or more additional regions are provided radially outward from the second region, the additional regions surround the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30 D. The additional region has the function of refracting an incident light beam onto the retina.

[0127] For example, the power profile V is expressed by a polynomial.

[0128] The following polynomials are for each region when the boundary position between the first region and the intermediate region is set to 1.625 mm, the boundary position between the intermediate region and the second region is set to 2.485 mm, and rmax is set to 3.000 mm (see FIG. 12B). First region: P I35 (r)=-2.87802590e-03r 4 -4.84408818e-04r 3 -2.39306469e-01r 2-1.30725682e-04r+20.000009 Middle area: P mid (r)=-3.75928693e-03r 4 -3.53365485e-03r 3 -3.65323646e-01r 2 +1.15 043830e-03r+20.347617 2nd area: P O25 (r)=-4.38903190e-04r 4 -7.72003537e-02r 3 -3.13958521e-01r 2 +4.43293306e-01r+19.934990

[0129] [Embodiment 4] The intraocular lens according to embodiment 4 is as follows: "In a total power profile in which the horizontal axis (unit: mm) represents the position when viewed in the radial direction from the lens center O, and the vertical axis (unit: D (diopter)) represents the total power T when the refractive power of the cornea and the power of the intraocular lens are added, when the position of the first boundary between the first region and the second region when viewed in the radial direction from the lens center O is set to r1, there is a total power profile TVa for the first region obtained by adding the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference total power profile TW to which the refractive power of the cornea is added from the base power, and multiplying this value by a predetermined ratio α (α is 10% or more and 50% or less) to the vertical axis value at each horizontal axis value of the aspherical reference total power profile TW; the intraocular lens is provided with a total power profile TVb for a second region obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference total power profile TW, to which the refractive power of the cornea has been added, from the maximum value rmax of the horizontal axis of the aspherical reference total power profile TW, and multiplying the result by a predetermined percentage β (β is 10% or more and 50% or less), and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference total power profile TW; and a total power profile TV that falls within a collective region of total power profiles obtained by combining the total power profiles TVa and TVb when the intersection of

[0130] In the total power profile TV1 for the first region, the vertical axis value may continuously increase as the horizontal axis value increases, and in the total power profile TV2 for the second region, the vertical axis value may continuously decrease as the horizontal axis value increases.

[0131] The absolute value of the average value of the tangent slope of the total power profile TV1 near the origin in the first region may be smaller than the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region, the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region may be larger than the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region, and the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region may be smaller than the absolute value of the average value of the tangent slope of the total power profile TV2 near the intermediate position in the second region. Here, "nearby" refers to, for example, within ±0.20 mm (or 0.10 mm) of the intermediate position in the case of the intermediate position.

[0132] For example, in the total power profile TV, the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at position r1 is the maximum positive value, and r1 is a value in the range of 1.5 mm or more and 2.3 mm or less.

[0133] For example, the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum value rmax on the horizontal axis of the total power profile TV is less than ±0.30D.

[0134] For example, the maximum value rmax on the horizontal axis of the total power profile TV is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0135] For example, one or more additional regions are provided radially outward from the second region, the additional regions surround the second region, and the additional regions have the function of refracting incident light beams onto the retina.

[0136] [Others] The intraocular lens of this embodiment is not limited to the above-described embodiment, but also includes forms to which various modifications and improvements have been made, as long as the specific effects obtained by the constituent elements of the invention and their combinations can be derived.

[0137] The area ratio between the first region and the second region in a plan view may be set to a range of 25:75 to 75:25.

[0138] In the first region, the power preferably decreases continuously, and in the second region, the power preferably decreases continuously.

[0139] Between the lens center O and the position r1 of the first boundary, it is preferable that the total power T obtained by adding the refractive power of the cornea and the power of the intraocular lens increases continuously.

[0140] Instead of directly patching together different power profiles, a profile that mimics the patchwork may be used. The polynomial that describes such a power profile is: P Np (r) = -8.31778546e-02r 8 + 9.97022762e-01r 7 - 4.79532863e+00r 6 + 1.18428403e+01r 5 - 1.60518818e+01r 4 + 1.18152492e+01r 3 - 4.57931927e+00r 2 + 6.59257903e-01r + 19.976408

[0141] Furthermore, although an intraocular lens has been exemplified in each embodiment, the technical idea (concept) of the present invention can also be applied to a design method for an intraocular lens, and to a manufacturing method for an intraocular lens in which an intraocular lens designed by the design method for an intraocular lens is manufactured by at least one of lathe turning, molding, and 3D printing.

[0142] [Specific Example] The intraocular lens of this embodiment is not limited to the above-described embodiment, but also includes various modifications and improvements within the scope of deriving specific effects obtained by the constituent elements of the invention and their combinations.

[0143] A specific example of the power profile will be described below. In the following example, the parameters of the above condition 1 are adopted.

[0144] 2 is a power profile showing the refractive power (vertical axis) provided by the optical part of an intraocular lens versus the distance (horizontal axis) from the lens center O in an embodiment of the present invention. In FIG. 2, the power profile of a spherical IOL is shown by a dotted line, the power profile of a zero-aberration IOL by a dashed line, the power profile of an aspherical IOL (aspherical reference power profile W) by a dashed-dotted line, and the IOL of the concept of the present invention by a solid line. In FIG. 2, in clockwise order, Ｉ５０ And, P Ｏ５０ And, P Ｏ１０ And, P Ｉ１０ The power profile V is contained in the area surrounded by (hatched portion).

[0145] Figure 3 is a power profile showing the refractive power (vertical axis) provided by the optical portion of the intraocular lens versus the distance from the lens center O (horizontal axis), and is a diagram showing a power profile Va obtained by multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power by a predetermined percentage α (α is a value between 10% and 50%, where α is 10%, i.e., I10, 35%, i.e., I35, and 50%, i.e., I50).

[0146] Figure 4 is a power profile showing the refractive power (vertical axis) provided by the optical part of the intraocular lens versus the distance from the lens center O (horizontal axis), and shows a power profile Vb obtained by adding the value obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W by a predetermined percentage β (β is 10% or more, i.e., O10, 25% or O25, and 50% or O50, out of a value between 10% and 50%) to the horizontal axis value at each vertical axis value of the aspherical reference power profile W.

[0147] FIG. 5 is an explanatory diagram of the superposition of I35 in FIG. 3 and O25 in FIG. 4. FIG. 6 is a diagram showing a power profile V formed by patching together the power profile Va (I35) for the first region and the power profile Vb (O25) for the second region in FIG. 5. Hereinafter, this power profile V will be referred to as "I35-O25." Hereinafter, the power profile V will be described in the same format. In both FIG. 5 and FIG. 6, the aspherical reference power profile W is shown as a dotted line. The aspherical reference power profile W is also shown as appropriate in subsequent figures. FIG. 7 is a diagram showing I10-O10, I40-O20, and I50-O50. In FIG. 7, the aspherical reference power profile W is shown as a solid line.

[0148] FIG. 8 shows a region (hatched portion) formed by the power profile when the intersection of the power profile Va for the first region (α is 10% or more and 50% or less) and the power profile Vb for the second region (β is 10% or more and 50% or less) is set at position ra on the horizontal axis.

[0149] 9 is a diagram showing a power profile V (solid line) in the [Other] embodiment of the present invention, in which different power profiles are not directly patched together, but a profile that imitates the patched-up power profile is used. The aspheric reference power profile W (dotted line), I10-O10 (dashed line), and I50-O50 (chain-dotted line) are also shown.

[0150] FIG. 10 is a diagram showing a power profile V (solid line, I35-O25, optical zone diameter 6.50 mm) when an additional region is provided.

[0151] The following specific examples mainly relate to the second embodiment.

[0152] Figure 11 shows I10-O10 and I50-O50, and for each power profile V, the average value of the tangent slope of the power profile V1 in the first region and the absolute value of the average value of the tangent slope of the power profile V2 in the second region are also shown. In both I10-O10 and I50-O50 in FIG. 11 , in the power profile V1 for the first region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V1 at each horizontal axis value continuously increases; in the power profile V2 for the second region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2 continuously decreases at each horizontal axis value; in the power profile V, the position r1 is the maximum positive value among the values ​​obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value of the power profile V2; and the value obtained by subtracting the vertical axis value of the aspherical reference power profile W from the vertical axis value at the maximum value rmax of the horizontal axis of the power profile V is less than 0.25D. Furthermore, the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three times or more the absolute value of the average value of the tangent slope of the power profile V1 in the first region. And, at each horizontal axis value of the power profile Vadd in the additional region, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

[0153] The numerical range of the absolute value of the average value of the tangent slope of the power profile V1 in the first region can be, for example, 0.73 D / mm as an upper limit and 0.46 D / mm as a lower limit, and the numerical range of the absolute value of the average value of the tangent slope of the power profile V2 in the second region can be, for example, 3.94 D / mm as an upper limit and 2.36 D / mm as a lower limit.

[0154] The following specific examples mainly relate to embodiment 3. Fig. 12A is a diagram showing a power profile V (solid line, I35-O25) when an intermediate region is provided. Fig. 12B is a diagram showing the case where the intermediate region of Fig. 12A is widened. Fig. 12C is a diagram showing a power profile V (solid line, I40-O40) when an intermediate region is provided.

[0155] The following specific examples mainly relate to embodiment 4. Fig. 13 is a table showing conditions adopted in a total power profile according to an embodiment of the present invention. Fig. 14 is a total power profile TV showing the total power T (vertical axis) when the refractive power of the cornea and the power of the intraocular lens are combined, versus the distance from the lens center O (horizontal axis).

[0156] The total power profile of FIG. 14 is designed in this example by using the widely known optical design software ZEMAX (registered trademark) (manufactured by ZEMAX Development Corporation, USA) to model the optical system of the cornea and the IOL and design the aspheric anterior surface of the IOL.

[0157] In Figure 14, the power profile of a spherical IOL is shown by a dotted line, the power profile of a zero-aberration IOL by a dashed line, and the IOL of the concept of the present invention by a solid line. Regarding the total power profile of an aspherical IOL, the total power profile when the spherical aberration value of the corneal model (shown as a negative value in each figure) is 0.07 μm is shown by a wide dotted line, the total power profile when it is 0.20 μm is shown by a narrow dotted line, and the total power profile when it is 0.27 μm is shown by a dashed-dotted line. Figure 15 shows the total power profile TV when the horizontal axis value rmax 3.0 mm is aligned with the vertical axis value when the horizontal axis value is zero.

[0158] Figure 16 shows the area (hatched portion) composed of the total power profile when the intersection of the total power profile TVa for the first area (α is 10% or more and 50% or less) and the total power profile TVb for the second area (β is 10% or more and 50% or less) is set to position ra on the horizontal axis.

[0159] The following specific examples of the present invention demonstrate the effect of providing robust image quality against changes in displacement, tilt, and pupil diameter while maintaining good image quality. At least one of I40-O40 and I35-O25 in the following specific examples exhibits an MTF value comparable to that of an aspherical IOL, while also providing robust image quality against changes in the above-mentioned variations. This level of robustness is comparable to that of a spherical IOL or a zero-aberration IOL. In other words, the present invention makes it possible to combine the best features of a spherical IOL, a zero-aberration IOL, and an aspherical IOL.

[0160] Before that, we will explain the MTF values ​​for a spherical IOL (dotted line), a zero-aberration IOL (dashed line), an aspherical IOL (narrow dotted line), and an IOL based on the concept of the present invention (I40-O40 is a solid line, I35-O25 is a dashed-dotted line) in a state where the above-mentioned changes do not occur. This explanation will be the same for the subsequent figures.

[0161] FIG. 17 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, and no displacement or tilt).

[0162] The plots are obtained by the ZEMAX method. Specific details of the test can be found in WO2008 / 078804 filed by the present applicant.

[0163] The MTF (Modulation Transfer Function) value is one of the measures for evaluating lens performance, and represents the degree to which the contrast of an object to be viewed can be faithfully reproduced on the image plane as a spatial frequency characteristic. A large MTF value means that the wearer perceives a high contrast when viewing an object through the lens.

[0164] FIG. 18 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, displacement 0.3 mm, no tilt).

[0165] FIG. 19 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, displacement 0.5 mm, no tilt).

[0166] FIG. 20 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, no displacement, tilt of 3 degrees).

[0167] FIG. 21 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, no displacement, inclination of 5 degrees).

[0168] FIG. 22 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, displacement 0.3 mm, tilt 3 degrees).

[0169] FIG. 23 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, displacement 0.4 mm, tilt 4 degrees).

[0170] FIG. 24 is a plot showing the MTF value (vertical axis) indicating contrast against the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) set to 3.0 to 4.5 mm, displacement 0.5 mm, inclination 5 degrees).

[0171] FIG. 25 is a plot showing the MTF value (vertical axis) indicating contrast against the displacement (horizontal axis) (object distance set to 2.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, inclination 0 to 5 degrees).

[0172] FIG. 26 is a plot showing the MTF value (vertical axis) indicating contrast against the displacement (horizontal axis) (object distance set to 3.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, inclination 0 to 5 degrees).

[0173] FIG. 27 is a plot showing the MTF value (vertical axis) indicating contrast against the displacement (horizontal axis) (object distance set to 4.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, inclination 0 to 5 degrees).

[0174] FIG. 28 is a plot showing the MTF value (vertical axis) indicating contrast against the tilt (horizontal axis) (object distance set to 2.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, and displacement from 0 to 0.5 mm).

[0175] FIG. 29 is a plot showing the MTF value (vertical axis) indicating contrast against the tilt (horizontal axis) (object distance set to 3.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, and displacement from 0 to 0.5 mm).

[0176] FIG. 30 is a plot showing the MTF value (vertical axis) indicating contrast against the tilt (horizontal axis) (object distance set to 4.0 m, aperture diameter (pupil diameter) set to 3.0 mm and 4.0 mm, and displacement from 0 to 0.5 mm).

[0177] [Embodiment 5] This embodiment can also be applied to an intraocular lens in which a positive power is added to at least a portion of the power profile in the first region to correct the near vision and / or intermediate vision of an aphakic patient.

[0178] The technical concept of the fifth embodiment can also be applied to monofocal lenses. For example, an enhanced monofocal intraocular lens (EM-IOL) can be used, which has an added positive power (e.g., one or more positive fixed powers) of 0.75D or more and 1.75D or less. The technical concept of the fifth embodiment can also be applied to multifocal lenses (e.g., an added positive power, i.e., an add power, of 2.5D or more and 4.0D or less), and extended depth-of-focus intraocular lenses (EDOF), which are intermediate lenses between multifocal lenses and EM-IOLs (e.g., an added positive power greater than 1.75D and less than 2.5D).

[0179] The region to which positive power is added is referred to as the inner first region. The region outside of this (located in a direction away from the lens center O) that has the same power profile Va as the first region described above is referred to as the outer first region. An example of this will be described below as embodiment 5 using Figures 31 to 34.

[0180] The intraocular lens according to the fifth embodiment is as follows: "An intraocular lens having at least two adjacent regions for vision correction that are concentric with a lens center O set with a predetermined base power, wherein the regions for vision correction are set as second regions surrounding the first region, in order from a first region including the lens center O toward the outside in the radial direction, and wherein a power profile is set with the position as viewed in the radial direction from the lens center O (unit: mm) as the horizontal axis and the power (unit: D (diopter)) as the vertical axis, wherein an aspherical reference power profile W is a power profile of a virtual aspherical lens that has a base power at the lens center O and that completely cancels out the positive vertical spherical aberration caused by the cornea, and wherein a power profile Va for the first region is a power profile obtained by multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspherical reference power profile W from the base power by a predetermined percentage α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspherical reference power profile W, "When a power profile Vb for the second region is obtained by subtracting the horizontal axis value at each vertical axis value of the aspherical reference power profile W from the maximum value rmax of the horizontal axis of the aspherical reference power profile W, multiplying the result by a predetermined percentage β (β is 10% or more and 50% or less), and adding the obtained value to the horizontal axis value at each vertical axis value of the aspherical reference power profile W, the first region comprises an inner first region having a power profile in which a positive power is added to the power profile Va for the first region, the second region comprises the power profile Vb, and the area of ​​the inner first region is less than 50% of the total area of ​​the first region."

[0181] For ease of explanation, the case where the lens center O is included in the inner first region will be referred to as embodiment 5A, and the case where this is not the case (the case where the lens center O is included in the innermost region described below, which has the same power profile as the power profile Va) will be referred to as embodiment 5B.

[0182] That is, in embodiment 5A, as shown in Figures 31A to 33A and 34, the inner first region may include the lens center O. Also, in embodiment 5B, as shown in Figures 31B to 33B, the first region may include an innermost region that has the same power profile Va as the outer first region and includes the lens center O, and the inner first region may surround the innermost region.

[0183] The symbols A and B in Figures 31 to 34 correspond to these embodiments 5A and 5B. Figure 34 belongs to embodiment 5A. Both embodiments are referred to as embodiment 5.

[0184] As in the above embodiments, the first region contacts the second region at the intersection point ra between the power profiles Va and Vb. As a specific example, the outer first region in the first region contacts the second region at the intersection point ra.

[0185] To correct near and / or intermediate vision in aphakic patients, the spectacle lens may comprise an inner first zone, consisting of one or more zones, in the interior region of the optic portion of the IOL of the present invention, as shown in Figures 31A, 31B, 32A, and 32B, where the area of ​​the inner first zone is less than 50% of the area of ​​the first zone.

[0186] The inner first region may include a constant power addition region having a power profile in which a constant positive power is added to the power profile Va for the outer first region.

[0187] "Power with a fixed positive power added to the power profile Va" indicates that at a specified distance from the lens center O, the deviation from the plot with a fixed positive power added to the power profile Va is less than ±0.30D (preferably less than ±0.15D).

[0188] The power added may be something other than a positive constant power. There may be a portion where a positive constant power is added and a portion where a non-positive power is added, and FIG. 32A shows an example. Specifically, in the portion of the power profile from 0 mm on the horizontal axis, which is the lens center O, to approximately 0.30 mm, a non-constant positive power is added. Moreover, this added power is greater than the positive constant power, or in other words, it causes a positive power deviation from the positive constant power. This portion is called the positive power deviation region. A positive constant power is added from approximately 0.30 mm to 0.80 mm. This portion is called the constant power addition region.

[0189] The positive power deviation region may have a power profile that is convex upward as shown in Figures 32A, 33A, and 34, or conversely, may have a power profile that is convex downward. It is preferable that the average value of the absolute values ​​of the differences between the power profile of the positive power deviation region and a power profile in which a fixed positive power is added to the power profile Va is large. In other words, it is preferable that the positive power deviation region has a power profile that is convex upward.

[0190] The power profile shapes in the regions constituting the inner first region may be different from each other. The shapes may be continuous, discontinuous (step-like), or a combination of different shapes. Figures 32A and 32B show a case where different power profiles, namely, a positive power deviation region and a fixed power addition region, are adjacently combined.

[0191] When viewed radially from the lens center O, the radial distance of the fixed power added region may be 33 to 67% of the radial distance of the inner first region (Figure 34). If the first region includes a region other than the inner first region whose average power is equal to that of the power profile Va, the average power of the inner first region may be 0.75 to 4.0 D greater than that of the region other than the inner first region. This configuration allows aphakic patients to see clear images of objects at specific near or intermediate distances. Examples of regions whose average power is equal to that of the power profile Va include the outer first region and / or the innermost region. In this paragraph, even if the outer first region and / or the innermost region do not completely match the power profile Va, the average power may satisfy the above relationship. Furthermore, the "region other than the inner first region" may exclude not only the inner first region but also the transition region described below. In accordance with this definition, the average power of the inner first region may be 0.75 to 4.0 D greater than the average power of the region other than the inner first region.

[0192] The intraocular lens may have two opposing surfaces and the lens body may have an inner first region on the anterior surface, the posterior surface, or both.

[0193] As shown in Figure 33A, in Embodiment 5A, the first region may include an outer transition region for smoothly connecting the inner first region to the outer first region. In addition, as shown in Figure 33B, in Embodiment 5B, the first region may include an inner transition region for smoothly connecting the inner first region to the innermost region. Both transition regions cause a decrease in power toward the power profile Va, in other words, a negative power deviation from the above-mentioned positive constant power.

[0194] Each transition region may have a power profile that is convex downward as shown in Figures 33A and 33B, or conversely, may have a power profile that is convex upward. It is preferable that the average value of the absolute values ​​of the differences between the power profile of the positive power deviation region and the power profile in which a positive fixed power is added to the power profile Va is small. In other words, it is preferable that the positive power deviation region has a power profile that is convex downward.

[0195] The present invention also allows for the case where the outer first region is not provided. That is, an inner first region (e.g., a fixed power addition region) or an outer transition region may be provided so as to contact the position ra of the intersection of the power profiles Va and Vb. In this case, the average power in the first region is increased, thereby enhancing near vision and intermediate vision.

[0196] The anterior surface, posterior surface, or both of the lens body of an intraocular lens having two opposing surfaces may be aspheric.

[0197] The front surface, the back surface, or both of the lens body of an intraocular lens having two opposing surfaces may have a toric surface with a cylindrical power for correcting astigmatism in an aphakic patient.

Claims

1. An intraocular lens having at least two adjacent regions for vision correction that are concentric around a lens center O having a predetermined base power set thereto, the regions for vision correction being set in order from a first region including the lens center O toward the radially outward direction as a second region surrounding the first region, and in a power profile in which the horizontal axis (unit: mm) represents the position as viewed radially from the lens center O and the vertical axis represents the power (unit: D (diopter)), the position of a first boundary between the first region and the second region as viewed radially from the lens center O is set to r1, and the power profile of a hypothetical aspheric lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea is set to an aspheric reference power profile W, an intraocular lens comprising: a power profile Va for a first region obtained by subtracting a vertical axis value at each horizontal axis value of an aspheric reference power profile W from a base power, multiplying the resultant value by a predetermined percentage α (α is 10% or more and 50% or less), and adding the resultant value to the vertical axis value at each horizontal axis value of the aspheric reference power profile W; and a power profile Vb for a second region obtained by subtracting a horizontal axis value at each vertical axis value of the aspheric reference power profile W from a maximum value rmax of the horizontal axis of the aspheric reference power profile W, multiplying the resultant value by a predetermined percentage β (β is 10% or more and 50% or less), and adding the resultant value to the horizontal axis value at each vertical axis value of the aspheric reference power profile W; and a power profile V that falls within a collection region of power profiles obtained by each combination of the power profiles Va and Vb, when the intersection of the above is set to a position ra on the horizontal axis.

2. The intraocular lens according to claim 1, wherein r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

3. The intraocular lens of claim 1, wherein, at each horizontal axis value of the power profile V, the position r1 is the maximum positive value among the values ​​obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile V.

4. The intraocular lens according to claim 1, wherein the maximum value rmax of the horizontal axis of the power profile V is within the range of 2.5 mm or more and 3.5 mm or less.

5. An intraocular lens as described in claim 1, comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

6. The intraocular lens according to claim 1, wherein the power profile V is expressed by a polynomial.

7. An intraocular lens as described in claim 1, comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting an incident light beam onto the retina.

8. An intraocular lens having at least two adjacent regions for vision correction, the regions for vision correction being concentric about a lens center O having a predetermined base power set thereto, the regions for vision correction being set in order from a first region including the lens center O toward the radially outward direction as a second region surrounding the first region, the position as viewed radially from the lens center O being set as the horizontal axis (unit: mm) and the power being set as the vertical axis (unit: D (diopter)) in a power profile in which the position as viewed radially from the lens center O is set as r1, and the power profile of a virtual aspheric lens having a base power at the lens center O and completely offsetting the positive vertical spherical aberration caused by the cornea is set as an aspheric reference power profile W, in the first region, the average value of the vertical axis value of the power profile V1 for the first region is greater than the average value of the vertical axis value of the aspheric reference power profile W, an intraocular lens, wherein in the second region, the average value of the vertical axis values ​​of the power profile V2 for the second region is greater than the average value of the vertical axis values ​​of the aspheric reference power profile W; in the power profile V1 for the first region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile V1 at each horizontal axis value increases continuously; and in the power profile V2 for the second region, as the horizontal axis value increases, the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile V2 decreases continuously at each horizontal axis value; in the power profile V, the position r1 is the positive maximum value among the values ​​obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile V2; and the value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value at the maximum value rmax of the horizontal axis of the power profile V is less than 0.25 D.

9. The intraocular lens of claim 8, wherein the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three or more times the absolute value of the average value of the tangent slope of the power profile V1 in the first region.

10. The intraocular lens according to claim 8, wherein r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

11. The intraocular lens according to claim 8, wherein the maximum value rmax of the horizontal axis of the power profile V is within the range of 2.5 mm or more and 3.5 mm or less.

12. The intraocular lens according to claim 8, comprising: a power profile Va for a first region obtained by subtracting the vertical axis value at each horizontal axis value of the aspheric reference power profile W from the base power, multiplying the result by a predetermined percentage α (α is 10% or more and 50% or less), and adding the resultant value to the vertical axis value at each horizontal axis value of the aspheric reference power profile W; and a power profile Vb for a second region obtained by subtracting the horizontal axis value at each vertical axis value of the aspheric reference power profile W from the maximum value rmax of the horizontal axis of the aspheric reference power profile W, multiplying the resultant value by a predetermined percentage β (β is 10% or more and 50% or less), and adding the resultant value to the horizontal axis value at each vertical axis value of the aspheric reference power profile W; and a power profile V that falls within a collection region of power profiles obtained by each combination of the power profiles Va and Vb, when the intersection of the above is located at position ra on the horizontal axis.

13. An intraocular lens as described in claim 8, comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, a value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

14. The intraocular lens according to claim 8, wherein the power profile V is expressed by a polynomial.

15. The intraocular lens of claim 8, further comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting an incident light beam onto the retina.

16. An intraocular lens having at least two regions for vision correction adjacent to each other and concentric with a lens center O having a predetermined base power, the regions for vision correction being set, in order from a first region including the lens center O toward the radially outward direction, as an intermediate region surrounding the first region and a second region surrounding the intermediate region, and in a power profile in which the horizontal axis (unit: mm) represents the position when viewed in the radial direction from the lens center O and the vertical axis (unit: D (diopter)) represents the power profile of a virtual aspheric lens having a base power at the lens center O and offsetting all of the positive vertical spherical aberration caused by the cornea, the power profile Va for the first region being obtained by multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspheric reference power profile W from the base power by a predetermined ratio α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspheric reference power profile W; an intraocular lens equipped with a power profile V that falls within a collective region of power profiles obtained by combinations of the power profiles Va, Vmid, and Vb, the power profile Vb being obtained by adding to the horizontal axis value at each vertical axis value of the aspheric reference power profile W a value obtained by subtracting the horizontal axis value at each vertical axis value of the aspheric reference power profile W from the maximum value rmax of the horizontal axis of the aspheric reference power profile W by a predetermined percentage β (β is 10% or more and 50% or less) and adding the obtained value to the horizontal axis value at each vertical axis value of the aspheric reference power profile W; and a power profile Vmid for an intermediate region having an average power smaller than the average power in the first region and larger than the average power in the second region.

17. The intraocular lens of claim 16, wherein the absolute value of the average value of the tangent slope of the power profile Vmid in the intermediate region is greater than the absolute value of the average value of the tangent slope of the power profile V1 in the first region and is smaller than the absolute value of the average value of the tangent slope of the power profile V2 in the second region.

18. The intraocular lens as described in claim 16, wherein, at each horizontal axis value of the power profile Vmid in the intermediate region, the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspheric reference power profile W from the vertical axis values ​​of the power profile Vmid is greater than the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspheric reference power profile W from the vertical axis values ​​of the power profile V1 at each horizontal axis value of the power profile V1 in the first region, and is greater than the average value of the values ​​obtained by subtracting the vertical axis values ​​of the aspheric reference power profile W from the vertical axis values ​​of the power profile V2 at each horizontal axis value of the power profile V2 in the second region.

19. The intraocular lens according to claim 16, wherein the intermediate region has a horizontal axis value falling within a range of 1.3 mm or more and 2.5 mm or less.

20. The intraocular lens according to claim 16, wherein the maximum value rmax of the horizontal axis of the power profile V is within the range of 2.5 mm or more and 3.5 mm or less.

21. The intraocular lens of claim 16, wherein the absolute value of the average value of the tangent slope of the power profile V2 in the second region is three or more times the absolute value of the average value of the tangent slope of the power profile V1 in the first region.

22. The intraocular lens of claim 16, comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and at each horizontal axis value of the power profile Vadd in at least one of the additional regions, a value obtained by subtracting the vertical axis value of the aspheric reference power profile W from the vertical axis value of the power profile Vadd is less than ±0.30D.

23. The intraocular lens of claim 16, wherein the power profile V is expressed by a polynomial.

24. The intraocular lens of claim 16, further comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting an incident light beam onto the retina.

25. An intraocular lens having at least two adjacent regions for vision correction that are concentric around a lens center O having a predetermined base power, the regions for vision correction being set in order from a first region including the lens center O toward the outside in the radial direction to a second region surrounding the first region, and when the power profile of a virtual aspheric lens that has a base power at the lens center O and completely offsets the positive vertical spherical aberration caused by the cornea is set as an aspheric reference power profile W, when the position as viewed radially from the lens center O is set as the horizontal axis (unit: mm) and the total power T obtained by adding up the refractive power of the cornea and the power of the intraocular lens is set as the vertical axis (unit: D (diopter)), when the position of the first boundary between the first region and the second region as viewed radially from the lens center O is set as r1, a total power profile TVa for the first region obtained by subtracting the vertical axis value at each horizontal axis value of the aspheric reference total power profile TW including the refractive power of the cornea from the base power, multiplying the result by a predetermined ratio α (α is 10% or more and 50% or less), and adding the result to the vertical axis value at each horizontal axis value of the aspheric reference total power profile TW; a total power profile TVb for the second region obtained by subtracting the horizontal axis value at each vertical axis value of the aspheric reference total power profile TW including the refractive power of the cornea from the maximum value rmax of the horizontal axis of the aspheric reference total power profile TW, multiplying the result by a predetermined ratio β (β is 10% or more and 50% or less), and adding the result to the horizontal axis value at each vertical axis value of the aspheric reference total power profile TW; The intraocular lens has a total power profile TV that falls within a collective region of total power profiles obtained by combining each of the total power profiles TVa and TVb when the intersection point of the above is located at position ra on the horizontal axis.

26. The intraocular lens of claim 25, wherein in the total power profile TV1 for the first region, the vertical axis value increases continuously as the horizontal axis value increases, and in the total power profile TV2 for the second region, the vertical axis value decreases continuously as the horizontal axis value increases.

27. The intraocular lens of claim 25, wherein the absolute value of the average value of the tangent slope of the total power profile TV1 near the origin in the first region is smaller than the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region, the absolute value of the average value of the tangent slope of the total power profile TV1 near the intermediate position in the first region is greater than the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region, and the absolute value of the average value of the tangent slope of the total power profile TV1 near position r1 in the first region is smaller than the absolute value of the average value of the tangent slope of the total power profile TV2 near the intermediate position in the second region.

28. The intraocular lens of claim 25, wherein in the total power profile TV, the value obtained by subtracting the vertical axis value at position r1 from the vertical axis value at r=0 is the maximum positive value, and r1 is a value within the range of 1.5 mm or more and 2.3 mm or less.

29. The intraocular lens according to claim 25, wherein the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum value rmax on the horizontal axis of the total power profile TV is less than ±0.30D.

30. The intraocular lens according to claim 25, wherein the maximum value rmax on the horizontal axis of the total power profile TV is within the range of 2.5 mm or more and 3.5 mm or less.

31. The intraocular lens of claim 25, further comprising one or more additional regions radially outward from the second region, the additional regions surrounding the second region, and the additional regions having the function of refracting an incident light beam onto the retina.

32. An intraocular lens having at least two adjacent regions for vision correction, the regions for vision correction being concentric around a lens center O having a predetermined base power, the regions for vision correction being set in order from a first region including the lens center O toward the radially outward direction, to a second region surrounding the first region, the horizontal axis (unit: mm) representing the position as viewed radially from the lens center O, and the vertical axis (unit: D (diopter)), in a power profile, the horizontal axis representing the position as viewed radially from the lens center O, and the vertical axis representing the power (unit: D (diopter)), the power profile of a virtual aspheric lens having a base power at the lens center O and offsetting all of the positive vertical spherical aberration caused by the cornea is set as an aspheric reference power profile W, and the power profile for the first region Va is set as a power profile obtained by multiplying the value obtained by subtracting the vertical axis value at each horizontal axis value of the aspheric reference power profile W from the base power by a predetermined ratio α (α is 10% or more and 50% or less) and adding the obtained value to the vertical axis value at each horizontal axis value of the aspheric reference power profile W, an intraocular lens, wherein when a power profile Vb for a second region is obtained by subtracting the horizontal axis value at each vertical axis value of the aspheric reference power profile W from the maximum horizontal axis value rmax of the aspheric reference power profile W and multiplying the result by a predetermined percentage β (β is 10% or more and 50% or less) and adding the obtained value to the horizontal axis value at each vertical axis value of the aspheric reference power profile W, the first region comprises an inner first region having a power profile in which a positive power is added to the power profile Va for the first region, the second region comprises a power profile Vb, and the area of ​​the inner first region is less than 50% of the total area of ​​the first region.

33. An intraocular lens as described in claim 32, wherein the first region, when viewed radially from the lens center O, comprises an inner first region and an outer first region surrounding the inner first region, the outer first region having a power profile Va and contacting the second region at the intersection of the power profiles Va and Vb.

34. The intraocular lens of claim 32, wherein the intraocular lens has two opposing surfaces, and the lens body has an inner first region on a front surface, a rear surface, or both.

35. The intraocular lens of claim 32, wherein the first region includes a region other than the inner first region, the region having an average power equal to the average power of the power profile Va, and the average power of the inner first region is 0.75 to 4.0 D greater than the average power of the region other than the inner first region.

36. The intraocular lens of claim 33, wherein the first region comprises an outer transition region for joining the inner first region to the outer first region.

37. The intraocular lens of claim 32, wherein the inner first region comprises a constant power addition region having a power profile in which a constant positive power is added to the power profile Va for the first region, and when viewed radially from the lens center O, the radial distance of the constant power addition region is 33 to 67% of the radial distance of the inner first region.

38. The intraocular lens of claim 32, wherein the inner first region includes a lens center O.

39. The intraocular lens of claim 33, wherein the first region includes an innermost region having a power profile Va for the first region and including a lens center O, and an inner first region surrounding the innermost region.

40. The intraocular lens of claim 39, wherein the first region includes an inner transition region for joining the inner first region to the innermost region.

41. The intraocular lens of claim 32, wherein the anterior surface, the posterior surface, or both of the lens body of the intraocular lens having two opposing surfaces are aspheric.

42. The intraocular lens of claim 32, wherein the anterior surface, posterior surface, or both of the lens body of the intraocular lens having two opposing surfaces comprises a toric surface having a cylindrical power for correcting astigmatism in an aphakic patient.

43. The intraocular lens according to any one of claims 1 to 42, which is made of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, PMMA copolymer, and copolymer of HEMA (hydroxyethyl methacrylate) containing collagen.

44. A method for designing an intraocular lens, comprising the steps of: designing an intraocular lens according to any one of claims 1 to 42.

45. A method for manufacturing an intraocular lens, comprising manufacturing an intraocular lens designed by the method for designing an intraocular lens according to claim 44 by at least one of lathe cutting, molding, and 3D printing.

Images