Peptide tethered particles and methods of use

Functionalized particles with THFP or HBAP tethered liposomes address rapid drug clearance and biofilm challenges by enhancing drug retention and disrupting biofilms, providing prolonged therapeutic effects and reducing antibiotic resistance.

WO2025171110A1 Publication Date: 2025-08-14UNIVERSITY OF CINCINNATI
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Patent Information

Application Number
PCT/US2025/014762
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-06
Filing Date
2025-02-06
Publication Date
2025-08-14

AI Technical Summary

Technical Problem

Current drug delivery systems face challenges in maintaining therapeutic efficacy due to rapid drug clearance from target areas, leading to frequent administrations and increased risk of systemic side effects, while biofilms cause significant morbidity and mortality with antibiotic-resistant bacteria.

Method used

Functionalized particles, such as liposomes tethered with triple-helix forming peptides (THFP) or hyaluronic acid binding peptides (HBAP), enhance drug retention and disrupt biofilm formation by targeting specific environments and utilizing steric hindrance mechanisms.

Benefits of technology

The functionalized particles significantly prolong drug residence time and inhibit or eradicate biofilms, reducing the need for frequent injections and minimizing adverse effects, while offering a resistance-free treatment strategy.

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Abstract

Provided herein are compositions including a functionalized particle, optionally a liposome and a peptide tethered to the liposome, wherein the peptide is selected from a triple-helix forming peptide (THFP), a hyaluronic acid binding peptide (HBAP), or a combination thereof. Also provided herein are methods of using the functionalized particles in increasing residence time of a therapeutic agent in a target treatment area for use in drug delivery and / or treating, eradicating, or inhibiting biofilm formation.
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