Anti-caries anhydrous gel, preparation method therefor, and use thereof, and tubular Anti-caries anhydrous gel

Through the combination of non-aqueous matrix and bioactive materials, combined with film-forming agents and antibacterial agents, a slowly released transparent film is formed, which solves the problem of poor stability of enamel remineralization products in saliva and achieves a long-term tooth caries prevention effect.

WO2025185328A1 Publication Date: 2025-09-11AIDITE (QINHUANGDAO) TECH CO LTD
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Patent Information

Application Number
PCT/CN2024/144658
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-05
Filing Date
2024-12-31
Publication Date
2025-09-11

AI Technical Summary

Technical Problem

Existing enamel remineralization products have poor stability under the action of saliva, and fluoride and bioactive materials are difficult to act effectively in the oral cavity for a long time, resulting in poor caries prevention effect.

Method used

It adopts a combination of non-aqueous matrix, bioactive materials, fluoride ion source, film-forming agent and antibacterial agent, dissolves the hydrophobic polymer film-forming agent in anhydrous ethanol to form a transparent film, controls the slow release of ingredients, and combines with the rotating brush pen design to achieve long-term tooth contact.

Benefits of technology

It significantly improves the remineralization effect of tooth enamel, prolongs the contact time between the anti-caries gel and teeth, enhances the antibacterial properties, is suitable for patients with metal brackets, and overcomes the problem of traditional products dissolving in saliva.

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Abstract

The present disclosure provides an anti-caries anhydrous gel, a preparation method therefor, and use thereof, and a tubular anti-caries anhydrous gel, relating to the technical field of dental gels. According to the present disclosure, polyethylene glycol and / or glycerol as well as absolute ethanol are used as an anhydrous matrix, thereby achieving coexistence of a bioactive material and a high-concentration fluorine ion source; by adding a hydrophobic copolymer as a film-forming agent, the anti-caries anhydrous gel can immediately form a layer of transparent film on the tooth surface after being applied to the teeth, so that effective components are controlled to be slowly released, thereby prolonging the action time of the anti-caries gel on the teeth, improving the remineralization effect of the anti-caries gel, and solving defects of traditional remineralization products such as dissolution after encountering saliva, which leads to short residence time on the tooth surface and thus causes local remineralization-promoting ions to be insufficient due to loss. By adding an antibacterial agent, formation of a dental plaque biofilm can be inhibited by means of the slow-release effect, thereby avoiding aggravation of white spot lesions caused by dental plaque accumulation, which is more conducive to preventing and treating orthodontic white spots during the correction treatment period.
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