Fused-ring quinolone derivative having antimalarial activity

Abstract

The present invention provides: a compound having an antimalarial action or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the same, in particular, a preventative agent and / or a therapeutic agent for malaria.　The present invention provides a compound represented by formula (I). (In the formula: Z represents -CR6aR6b-CR7aR7b- or the like; R6a, R6b, R7a, and R7b each independently represent a hydrogen atom or the like; R1 represents a hydrogen atom or the like; R2 represents a hydrogen atom or the like; R3 represents a hydrogen atom or the like; R4 represents a hydrogen atom or the like; L1 represents -CR9aR9b- or the like; R9a and R9b each independently represent a hydrogen atom or the like; L2 represents a single bond or the like; and R5 represents a substituted or unsubstituted aromatic carbon ring group or the like.)

Description

Fused quinolone derivatives with antimalarial activity.

[0001] The present invention relates to a compound having antimalarial activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same, particularly an agent for preventing and / or treating malaria.

[0002] Malaria is a mosquito-borne infectious disease prevalent primarily in tropical regions, currently causing approximately 200 million cases and 600,000 deaths annually. Because many of these deaths occur among children under the age of five and pregnant women, drug options for treatment and prevention are extremely limited. For example, sulfadoxine and pyrimethamine are used in combination to prevent malaria in children under the age of five and pregnant women, but this approach is not sufficiently effective. Artemisinin-based combination therapy (ACT) is currently widely used in malaria treatment, but artemisinin-resistant malaria is spreading, particularly in Southeast Asia. Furthermore, existing treatments require one to two doses per day for three or more days, which is thought to increase the risk of drug resistance if patients do not complete the medication regimen. The World Health Organization (WHO) has set a goal of reducing malaria cases by 90% by 2030, aiming for the eventual elimination or eradication of malaria, but the rate of decline in malaria cases has slowed in recent years (Non-Patent Document 1). For these reasons, there is a need for new therapeutic drugs that overcome resistance to existing drugs, are highly effective and safe, and provide complete treatment with a single dose, or new preventive drugs that maintain their effectiveness for a long period of time (Non-Patent Documents 2-4). Malaria is a disease caused by eukaryotic protozoa of the genus Plasmodium. In recent years, inhibitors of the mitochondrial respiratory chain have been found to be highly effective in treatment and prevention (Non-Patent Documents 5-7). For example, atovaquone is known to inhibit the function of Complex III of the malaria mitochondrial respiratory chain. It has shown high efficacy as a therapeutic and preventive drug and is widely used, especially in developed countries, in combination with proguanil as a preventive drug (Non-Patent Documents 6-7). However, atovaquone and proguanil have not been widely used in endemic areas due to the fact that their use is not recommended for pregnant women, they require once-daily administration, and their price is low. Recently, ELQ-300 and ELQ-331 have been reported as new compounds that also inhibit malaria Complex III (Patent Documents 1-2 and Non-Patent Documents 8-10). Vaccines are widely known as a means of preventing infectious diseases, but it is known that even adults who have been infected repeatedly have only limited immunity to malaria, making it difficult to develop a highly effective vaccine.Although RTS,S / AS01 has recently been put into practical use as a vaccine for preventing malaria infection, it has been reported that its preventive effect is insufficient and that its effectiveness weakens over time (Non-Patent Document 11). For these reasons, there remains a high need for pharmaceutical malaria prevention. Compounds known to have antimalarial activity are disclosed in Patent Documents 1-21, Non-Patent Documents 8-10, and 12-51. However, none of these documents describe compounds related to the present invention. Furthermore, Patent Document 22 describes the following compound: Patent Document 23 describes the following compound. Patent Document 24 describes the following compound. However, no antimalarial activity has been described or suggested in any of the documents.

[0003] : International Publication No. 2012 / 167237: International Publication No. 2017 / 015360: International Publication No. 2010 / 065905: International Publication No. 2017 / 112678: International Publication No. 2017 / 127820: International Publication No. 2010 / 142741: International Publication No. 2010 / 081904: International Publication No. 2006 / 094799: International Publication No. 2009 / 068623: International Publication No. 2012 / 069856: International Publication No. 2017 / 103615: International Publication No. 2008 / 064011: U.S. Patent Application Publication No. 2020 / 03 69616: WO 2020 / 051130: WO 2018 / 133862: WO 2017 / 222996: U.S. Patent Application Publication No. 2013 / 0123258: U.S. Patent Application Publication No. 2012 / 0115904: U.S. Patent Application Publication No. 2012 / 0010237: WO 2021 / 204952: WO 2022 / 250104: WO 2017 / 173274: WO 2016 / 168540: European Patent Application Publication No. 0481429

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[0005] An object of the present invention is to provide a compound having antimalarial activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same, particularly an agent for preventing and / or treating malaria.

[0006] The present invention relates to the following: (1) A compound of formula (I): (Wherein, Z is —CR６ａ R ６ｂ -CR ７ａ R ７ｂ -, -CR ８ａ R ８ｂ -, -CH=CH-, -CH=N-, or -N=CH-; R ６ａ and R ６ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R ７ａ and R ７ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R ８ａ and R ８ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R １ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ２ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ３ is a hydrogen atom, a halogen atom, a cyano, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted alkyloxy, a substituted or unsubstituted alkenyloxy, or a substituted or unsubstituted alkynyloxy, provided that Z is -CR ８ａ R ８ｂ -, then halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ４is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; L １ is a single bond or -CR ９ａ R ９ｂ - and R ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, a cyano, a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group; or ７ａ and R ９ａ may be taken together with the carbon atom to which they are attached to form a substituted or unsubstituted non-aromatic heterocycle; L ２ is a single bond, a substituted or unsubstituted alkylene, or a substituted or unsubstituted non-aromatic carbocyclic diyl; R ５ is a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group), excluding the following compounds: ), or a pharmaceutically acceptable salt thereof. ４ (3) The compound according to (1), or a pharmaceutically acceptable salt thereof, wherein R is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy. ４ (4) The compound according to (1), or a pharmaceutically acceptable salt thereof, wherein R ２ (5) The compound according to any one of (1) to (3), wherein R is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof. １(6) The compound according to any one of (1) to (4), wherein R is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof. ３ (7) The compound according to any one of (1) to (5), wherein L is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof. １ But, -CR ９ａ R ９ｂ - and; L ２ (8) The compound according to any one of (1) to (6), wherein L is a single bond, or a substituted or unsubstituted alkylene, or a pharmaceutically acceptable salt thereof. １ But, -CR ９ａ R ９ｂ - and R ９ａ and R ９ｂ is a hydrogen atom; ２ (9) The compound according to any one of (1) to (6), wherein Z is —CR ６ａ R ６ｂ -CR ７ａ R ７ｂ (10) The compound according to any one of (1) to (8), wherein Z is -, -CH=CH-, -CH=N-, or -N=CH-, or a pharmaceutically acceptable salt thereof. ６ａ R ６ｂ -CR ７ａ R ７ｂ (11) The compound according to any one of (1) to (8), wherein Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ - and R ６ａ , R ６ｂ , R ７ａ and R ７ｂ (12) The compound according to any one of (1) to (8), or a pharmaceutically acceptable salt thereof, wherein R ５(13) The compound according to any one of (1) to (11), wherein R is a substituted or unsubstituted aromatic carbocyclic group, or a substituted or unsubstituted aromatic heterocyclic group, or a pharmaceutically acceptable salt thereof. ５ (13-A) The compound according to any one of (1) to (11), wherein R is a substituted or unsubstituted aromatic carbocyclic group, or a pharmaceutically acceptable salt thereof. ５ (13-B) The compound according to any one of (1) to (11), wherein R is substituted or unsubstituted phenyl, or a pharmaceutically acceptable salt thereof. ５ But the formula: (In the formula, R １０ , R １１ , R １２ , R １３ , and R １４are each independently a hydrogen atom, halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, cyano, nitro, nitroso, azido, hydrazino, ureido, amidino, guanidino, pentafluorothio, trialkylsilyl, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylcarbonyloxy optionally substituted with substituent group α, alkenylcarbonyloxy optionally substituted with substituent group α, alkynylcarbonyloxy optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, substituted with substituent group α alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, carbamoyl optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ',Aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ', aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ', Aromatic carbocyclic carbonyl optionally substituted with substituent group γ', non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ, aromatic heterocyclic carbonyl optionally substituted with substituent group γ', non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyl optionally substituted with substituent group γ, aromatic heterocyclic alkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkenyl optionally substituted with substituent group γ', aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ,Non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, optionally substituted with substituent group γ' non-aromatic heterocyclic sulfanyl, aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ,non-aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ'; substituent group α is halogen, hydroxy, carboxy, alkyloxy, haloalkyloxy, alkenyloxy, alkynyloxy, sulfanyl, and cyano; Substituent group β is halogen, hydroxy, carboxy, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic alkyl optionally substituted with a substituent group γ',Aromatic carbocyclic carbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ', aromatic heterocyclic carbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ' aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', Substituent group γ: substituent group α, amino, an aromatic carbocyclic group optionally substituted with substituent group γ", a non-aromatic carbocyclic group optionally substituted with substituent group γ'", an aromatic heterocyclic group optionally substituted with substituent group γ", an aromatic carbocycle-oxy optionally substituted with substituent group γ", alkyloxycarbonyl, monoalkylaminoalkyl, dialkylaminoalkyl, aromatic carbocycle-alkyloxycarbonyl optionally substituted with substituent group γ", alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkylcarbonyl, haloalkylcarbonyl, alkenylcarbonyl, and alkynylcarbonyl; substituent group γ': substituent group γ and oxo; substituent group γ'': substituent group α, alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkylcarbonyl, and haloalkylcarbonyl;(13-C) R, or a pharmaceutically acceptable salt thereof. ５ But the formula: (In the formula, R １０represents a hydrogen atom, halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted by substituent group β, imino optionally substituted by substituent group β, sulfamoyl optionally substituted by substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic carbocyclic-haloalkyl optionally substituted with a substituent group γ,Non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', Aromatic carbocyclic sulfanyl optionally substituted with group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', substituted with substituent group γ aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ',aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ'; R, １１represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ'; R, １２represents a hydrogen atom, halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ'; R, １３represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ'; R, １４represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic (13-D) R is a group represented by the formula (1): carbocyclic haloalkyl, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', or non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ'. ５ But the formula: (In the formula, R １０represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ' alkyl, aromatic heterocyclic alkyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkyl optionally substituted by substituent group γ', aromatic carbocyclic alkenyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkenyl optionally substituted by substituent group γ', aromatic heterocyclic alkenyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted by substituent group γ', aromatic carbocyclic haloalkyl optionally substituted by substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted by substituent group γ', aromatic heterocyclic haloalkyl optionally substituted by substituent group γ,Non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic halo Alkyloxy, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ phenyl, non-aromatic heterocyclic sulfinyl optionally substituted by substituent group γ', aromatic carbocyclic sulfonyl optionally substituted by substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted by substituent group γ', aromatic heterocyclic sulfonyl optionally substituted by substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted by substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted by substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted by substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted by substituent group γ', aromatic carbo ...onyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γR is an aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ and a non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ′; １１ represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ R, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ'; １２represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β,Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ'; R １３represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted, aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ';R; １４ is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'), or a pharmaceutically acceptable salt thereof. ５ But the formula: (In the formula, R １０represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic optionally substituted with substituent group γ' ring alkenyl, aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ',Aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclylsulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ'; R, １１ is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １２represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic oxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ, an aromatic heterocyclic oxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ', an aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ, an aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', an aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １４ is a hydrogen atom, halogen, cyano, C1-C3 alkyl optionally substituted with substituent group α, or C1-C3 alkyloxy optionally substituted with substituent group α), or a pharmaceutically acceptable salt thereof. ５ But the formula: (In the formula, R １０is alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ'; R １１ is a hydrogen atom; R １２ is alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ'; R １３ is C1-C3 alkyl optionally substituted with halogen or substituent group α; R １４(13-G) R is a group represented by the formula (I) or (II), or a pharmaceutically acceptable salt thereof. ５ But the formula: (In the formula, R １０ is alkyloxy optionally substituted with substituent group α, aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ; R １１ is a hydrogen atom; R １２ is alkyloxy optionally substituted with substituent group α, aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ; R １３ is halogen, or haloC1-C3 alkyl; R １４ (13-H)R is a group represented by the formula (1), or a pharmaceutically acceptable salt thereof. １０ and R １３ is not a hydrogen atom; R １１ , R １２ and R １４ is a hydrogen atom, or a pharmaceutically acceptable salt thereof. １０ and R １２ is not a hydrogen atom; R １１ , R １３ and R １４ is a hydrogen atom, or a pharmaceutically acceptable salt thereof. １０ , R １２ and R １３ is not a hydrogen atom; R １１ and R １４(14) The compound according to (1), or a pharmaceutically acceptable salt thereof, which is selected from the group consisting of compounds I-045, I-063, I-079, I-085, I-090, I-091, I-098, I-137, I-144, I-147, I-152, I-213, I-215, I-227, I-236, I-241, I-244, I-250, I-255, I-261, I-262, I-263, I-267, I-268, I-270, I-273, I-274, I-275, I-277, I-278, and I-279. (15) A pharmaceutical composition comprising the compound according to any one of (1) to (14), (13-A) to (13-J), or a pharmaceutically acceptable salt thereof. (16) A pharmaceutical composition for preventing and / or treating malaria, comprising the compound according to any one of (1) to (14), (13-A) to (13-J), or a pharmaceutically acceptable salt thereof. (17) A method for treating and / or preventing malaria, comprising administering the compound according to any one of (1) to (14), (13-A) to (13-J), or a pharmaceutically acceptable salt thereof. (18) Use of the compound according to any one of (1) to (14), (13-A) to (13-J), or a pharmaceutically acceptable salt thereof, for the manufacture of an agent for treating and / or preventing malaria. (19) A compound according to any one of (1) to (14), (13-A) to (13-J), or a pharmaceutically acceptable salt thereof, for use in the treatment and / or prevention of malaria.

[0007] The compound according to the present invention is a quinolone derivative having a fused ring structure, has excellent antimalarial activity, and is useful as a therapeutic and / or preventive agent for malaria. Preferably, the compound according to the present invention has a long half-life in the body and excellent tissue distribution, and is therefore useful as a pharmaceutical.

[0008] The meaning of each term used in this specification is explained below. Unless otherwise specified, each term has the same meaning whether used alone or in combination with other terms. The term "consisting of" means having only the constituent elements. The term "comprises" means not being limited to the constituent elements and does not exclude unrecited elements. The present invention will be explained below with reference to exemplary embodiments. Throughout this specification, singular expressions should be understood to include the plural concept unless otherwise specified. Therefore, singular articles (e.g., "a," "an," "the," etc. in English) should be understood to include the plural concept unless otherwise specified. Furthermore, terms used in this specification should be understood to have the meaning commonly used in the art unless otherwise specified. Therefore, unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the event of conflict, the present specification (including definitions) will prevail.

[0009] The term "halogen" includes fluorine, chlorine, bromine, and iodine atoms. Particularly, fluorine and chlorine atoms are preferred.

[0010] The term "alkyl" encompasses straight-chain or branched hydrocarbon groups having 1 to 15 carbon atoms, preferably 1 to 10 carbon atoms, more preferably 1 to 6 carbon atoms, and even more preferably 1 to 4 carbon atoms. Examples include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl, and n-decyl. Preferred embodiments of "alkyl" include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, and n-pentyl. More preferred embodiments include methyl, ethyl, n-propyl, isopropyl, n-butyl, and tert-butyl.

[0011] "C1-C3 alkyl" includes methyl, ethyl, n-propyl, and isopropyl.

[0012] "Haloalkyl" refers to a group in which one or more of the above-mentioned "halogens" are bonded to the above-mentioned "alkyl". Examples include monofluoromethyl, difluoromethyl, 2-monofluoroethyl, 3-monofluoropropyl, 2,2,3,3,3-pentafluoropropyl, monochloromethyl, trifluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 2,2-difluoroethyl, 1,2-dibromoethyl, 1,1,1-trifluoropropan-2-yl, 2,2,3,3,4,4,4-heptafluorobutyl, and the like. Preferred embodiments of "haloalkyl" include trifluoromethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 2,2-difluoroethyl, 3,3,3-trifluoropropyl, 2,2,3,3,3-pentafluoropropyl, and 2,2,3,3,4,4,4-heptafluorobutyl.

[0013] The term "alkenyl" encompasses straight-chain or branched hydrocarbon groups having 2 to 15 carbon atoms, preferably 2 to 10 carbon atoms, more preferably 2 to 6 carbon atoms, and even more preferably 2 to 4 carbon atoms, and having one or more double bonds at any position. Examples include vinyl, allyl, propenyl, isopropenyl, butenyl, isobutenyl, prenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, tridecenyl, tetradecenyl, and pentadecenyl. Preferred embodiments of "alkenyl" include vinyl, allyl, propenyl, isopropenyl, and butenyl.

[0014] "Alkynyl" includes a straight-chain or branched hydrocarbon group having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms, more preferably 2 to 6 carbon atoms, and even more preferably 2 to 4 carbon atoms, and having one or more triple bonds at any position. It may further have a double bond at any position. Examples include ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonynyl, and decynyl. Preferred embodiments of "alkynyl" include ethynyl, propynyl, butynyl, and pentynyl.

[0015] The term "alkylene" includes a straight-chain or branched divalent hydrocarbon group having 1 to 15 carbon atoms, preferably 1 to 10 carbon atoms, more preferably 1 to 6 carbon atoms, and even more preferably 1 to 4 carbon atoms. Examples include methylene, ethylene, trimethylene, propylene, tetramethylene, pentamethylene, and hexamethylene.

[0016] "C1-C3 alkylene" includes methylene, ethylene, trimethylene, and propylene. It also includes the following groups:

[0017] The term "aromatic carbocyclic group" refers to a cyclic aromatic hydrocarbon group having one or more rings. Examples include phenyl, naphthyl, anthryl, and phenanthryl. A preferred embodiment of the "aromatic carbocyclic group" is phenyl.

[0018] The term "aromatic carbocyclic ring" refers to a ring derived from the above-mentioned "aromatic carbocyclic group".

[0019] The term "non-aromatic carbocyclic group" refers to a monocyclic or bicyclic or multicyclic saturated or non-aromatic unsaturated hydrocarbon group. A bicyclic or multicyclic "non-aromatic carbocyclic group" also includes a monocyclic or bicyclic or multicyclic non-aromatic carbocyclic group to which the ring of the above-mentioned "aromatic carbocyclic group" is fused. Furthermore, the term "non-aromatic carbocyclic group" also includes bridged groups or groups that form spiro rings as shown below. The monocyclic non-aromatic carbocyclic group preferably has 3 to 16 carbon atoms, more preferably 3 to 12 carbon atoms, even more preferably 3 to 8 carbon atoms, and still more preferably 3 to 6 carbon atoms. Examples include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclohexadienyl. The bicyclic or higher non-aromatic carbocyclic group preferably has 8 to 20 carbon atoms, more preferably 8 to 16 carbon atoms. Examples include indanyl, indenyl, acenaphthyl, tetrahydronaphthyl, and fluorenyl.

[0020] The term "non-aromatic carbocyclic ring" refers to a ring derived from the above-mentioned "non-aromatic carbocyclic group".

[0021] "Non-aromatic carbocyclic diyl" means a divalent group derived from the above "non-aromatic carbocyclic ring". Examples include cyclopropanediyl, cyclobutanediyl, cyclopentanediyl, cyclohexanediyl, cycloheptanediyl, cyclooctanediyl, bicyclo[2.2.2]octanediyl, bicyclo[2.2.1]heptanediyl, adamantanediyl, and the like. One carbon atom may have two bonds. Examples include cyclohexane-1,1-diyl, adamantane-2,2-diyl, and the like.

[0022] The term "aromatic heterocyclic group" refers to a monocyclic or bicyclic or multicyclic aromatic cyclic group having one or more identical or different heteroatoms selected from O, S, and N in the ring. Bicyclic or multicyclic aromatic heterocyclic groups also include those in which the rings in the "aromatic carbocyclic group" are fused to a monocyclic or bicyclic or multicyclic aromatic heterocyclic group, and the bond may be on any of the rings. Monocyclic aromatic heterocyclic groups are preferably 5- to 8-membered, and more preferably 5- or 6-membered. Examples of 5-membered aromatic heterocyclic groups include pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, furyl, thienyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiadiazolyl, etc. Examples of 6-membered aromatic heterocyclic groups include pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, etc. The bicyclic aromatic heterocyclic group is preferably 8- to 10-membered, and more preferably 9- or 10-membered. Examples include indolyl, isoindolyl, indazolyl, indolizinyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzimidazolyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiadiazolyl, benzofuryl, isobenzofuryl, benzothienyl, benzotriazolyl, imidazopyridyl, triazolopyridyl, imidazothiazolyl, pyrazinopyridazinyl, oxazolopyridyl, and thiazolopyridyl. The tricyclic or more aromatic heterocyclic group is preferably 13- to 15-membered. Examples include carbazolyl, acridinyl, xanthenyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, dibenzofuryl, and the like.

[0023] The term "aromatic heterocycle" refers to a ring derived from the above-mentioned "aromatic heterocyclic group".

[0024] The term "non-aromatic heterocyclic group" refers to a monocyclic or bicyclic or more non-aromatic cyclic group having one or more identical or different heteroatoms selected from O, S, and N in the ring. Bicyclic or more non-aromatic heterocyclic groups include monocyclic or bicyclic or more non-aromatic heterocyclic groups fused with the respective rings of the above-mentioned "aromatic carbocyclic group," "non-aromatic carbocyclic group," and / or "aromatic heterocyclic group," as well as monocyclic or bicyclic or more non-aromatic carbocyclic groups fused with the rings of the above-mentioned "aromatic heterocyclic group," and the bond may be on any of the rings. Furthermore, the term "non-aromatic heterocyclic group" also includes bridged groups or groups forming spiro rings as described below. The monocyclic non-aromatic heterocyclic group is preferably 3 to 8 members, more preferably 5 or 6 members. Examples of 3-membered non-aromatic heterocyclic groups include thiiranyl, oxiranyl, and aziridinyl. Examples of 4-membered non-aromatic heterocyclic groups include oxetanyl and azetidinyl. Examples of 5-membered non-aromatic heterocyclic groups include oxathiolanyl, thiazolidinyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, tetrahydrofuryl, dihydrothiazolyl, tetrahydroisothiazolyl, dioxolanyl, dioxolyl, and thiolanyl. Examples of 6-membered non-aromatic heterocyclic groups include dioxanyl, thianyl, piperidyl, piperazinyl, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino, dihydropyridyl, tetrahydropyridyl, tetrahydropyranyl, dihydrooxazinyl, tetrahydropyridazinyl, hexahydropyrimidinyl, dioxazinyl, thiinyl, and thiazinyl. Examples of 7-membered non-aromatic heterocyclic groups include hexahydroazepinyl, tetrahydrodiazepinyl, and oxepanyl. Non-aromatic heterocyclic groups having two or more rings preferably have 8 to 20 members, and more preferably have 8 to 10 members. Examples include indolinyl, isoindolinyl, chromanyl, and isochromanyl.

[0025] The term "non-aromatic heterocycle" refers to a ring derived from the above-mentioned "non-aromatic heterocyclic group".

[0026] "R ７ａ and R ９ａ Examples of "a non-aromatic heterocycle formed by combining each of these together with the carbon atom to which they are bonded" include the following rings. Preferred examples include the following rings:

[0027] "Trialkylsilyl" refers to a group in which three of the above-mentioned "alkyl" groups are bonded to a silicon atom. The three alkyl groups may be the same or different. Examples include trimethylsilyl, triethylsilyl, and tert-butyldimethylsilyl.

[0028] In this specification, "optionally substituted with substituent group α" means "optionally substituted with one or more groups selected from substituent group α." The same applies to substituent groups β, γ, γ', γ" and γ'".

[0029] Examples of substituents such as "substituted alkyl," "substituted C1-C3 alkyl," "substituted alkylene," "substituted C1-C3 alkylene," "substituted alkenyl," "substituted alkynyl," "substituted alkyloxy," "substituted C1-C3 alkyloxy," "substituted alkenyloxy," "substituted alkynyloxy," "substituted alkylcarbonyloxy," "substituted alkenylcarbonyloxy," "substituted alkynylcarbonyloxy," "substituted alkylcarbonyl," "substituted alkenylcarbonyl," "substituted alkynylcarbonyl," "substituted alkyloxycarbonyl," "substituted alkenyloxycarbonyl," "substituted alkynyloxycarbonyl," "substituted alkylsulfanyl," "substituted alkenylsulfanyl," "substituted alkynylsulfanyl," "substituted alkylsulfinyl," "substituted alkenylsulfinyl," "substituted alkynylsulfinyl," "substituted alkylsulfonyl," "substituted alkenylsulfonyl," and "substituted alkynylsulfonyl" include the following Substituent Group A. A carbon atom at any position may be bonded to one or more groups selected from the following Substituent Group A. Substituent group A: halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, cyano, nitro, nitroso, azido, hydrazino, ureido, amidino, guanidino, pentafluorothio, trialkylsilyl, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylcarbonyloxy optionally substituted with substituent group α, alkenylcarbonyloxy optionally substituted with substituent group α, alkynylcarbonyloxy optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α,alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, carbamoyl optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ', aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ, (i), aromatic carbocyclic carbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ', aromatic heterocyclic carbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ,Non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, substituted Non-aromatic heterocyclyl sulfanyl optionally substituted with a group γ', aromatic carbocyclic sulfinyl optionally substituted with a substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with a substituent group γ', aromatic heterocyclyl sulfinyl optionally substituted with a substituent group γ, non-aromatic heterocyclyl sulfinyl optionally substituted with a substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ', aromatic heterocyclyl sulfonyl optionally substituted with a substituent group γ and non-aromatic heterocyclyl sulfonyl optionally substituted with a substituent group γ'.

[0030] Substituent group α: halogen, hydroxy, carboxy, alkyloxy, haloalkyloxy, alkenyloxy, alkynyloxy, sulfanyl, and cyano.

[0031] Substituent group β: halogen, hydroxy, carboxy, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α,Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic carbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ', aromatic heterocyclic carbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ'.

[0032] Substituent group γ: substituent group α, amino, aromatic carbocyclic group optionally substituted with substituent group γ'', non-aromatic carbocyclic group optionally substituted with substituent group γ''', aromatic heterocyclic group optionally substituted with substituent group γ'', aromatic carbocycle-oxy optionally substituted with substituent group γ'', alkyloxycarbonyl, monoalkylaminoalkyl, dialkylaminoalkyl, aromatic carbocycle-alkyloxycarbonyl optionally substituted with substituent group γ'', alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkylcarbonyl, haloalkylcarbonyl, alkenylcarbonyl, and alkynylcarbonyl.

[0033] Substituent group γ': Substituent group γ and oxo.

[0034] Substituent group γ″: Substituent group α, alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkylcarbonyl, haloalkylcarbonyl, alkenylcarbonyl, and alkynylcarbonyl.

[0035] Substituent group γ′″: Substituent group γ″ and oxo.

[0036] Substituents on the ring of an "aromatic carbocyclic group" and "aromatic heterocyclic group", such as "substituted aromatic carbocyclic group", "substituted aromatic carbocyclic groupoxy", "substituted aromatic heterocyclic groupoxy", "substituted aromatic carbocyclic groupcarbonyloxy", "substituted aromatic heterocyclic groupcarbonyloxy", "substituted aromatic carbocyclic groupcarbonyl", "substituted aromatic heterocyclic groupcarbonyl", "substituted aromatic carbocyclic groupcarbonyl", "substituted aromatic heterocyclic groupcarbonyl", "substituted aromatic carbocyclic groupcarbonyl", "substituted aromatic carbocyclic groupoxycarbonyl", "substituted aromatic heterocyclic groupoxycarbonyl", "substituted aromatic carbocyclic groupsulfanyl", "substituted aromatic heterocyclic groupsulfanyl", "substituted aromatic carbocyclic groupsulfinyl", "substituted aromatic heterocyclic groupsulfinyl", "substituted aromatic carbocyclic groupsulfonyl", and "substituted aromatic heterocyclic groupsulfonyl" include the following substituent group B. An atom at any position on the ring may be bonded to one or more groups selected from the following substituent group B. Substituent group B: halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, cyano, nitro, nitroso, azido, hydrazino, ureido, amidino, guanidino, pentafluorothio, trialkylsilyl, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylcarbonyloxy optionally substituted with substituent group α, alkenylcarbonyloxy optionally substituted with substituent group α, alkynylcarbonyloxy optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α,alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, carbamoyl optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ', aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ', aromatic carbocyclic carbonyl, non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ', aromatic heterocyclic carbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ,Non-aromatic carbocyclic alkenyl optionally substituted with substituent group γ', aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, substituted with substituent group γ' non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ carbonyl, non-aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ',Aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', substituted with substituent group γ aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ, aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ'.

[0037]

[0049] Substituents on the ring of the "non-aromatic carbocyclic group", "substituted non-aromatic heterocyclic group", "substituted non-aromatic carbocycle-diyl", "substituted non-aromatic carbocycle-oxy", "substituted non-aromatic heterocycle-oxy", "substituted non-aromatic carbocycle-carbonyloxy", "substituted non-aromatic heterocycle-carbonyloxy", "substituted non-aromatic carbocycle-carbonyl", "substituted non-aromatic heterocycle-carbonyl", "substituted non-aromatic carbocycle-oxycarbonyl", "substituted non-aromatic heterocycle-oxycarbonyl", "substituted non-aromatic carbocycle-sulfanyl", "substituted non-aromatic heterocycle-sulfanyl", "substituted non-aromatic carbocycle-sulfinyl", "substituted non-aromatic heterocycle-sulfinyl", "substituted non-aromatic carbocycle-sulfonyl", and "substituted non-aromatic heterocycle-sulfonyl" include the following Substituent Group C. An atom at any position on the ring may be bonded to one or more groups selected from the following Substituent Group C. Substituent Group C: Substituent Group B and oxo.

[0038] When a "non-aromatic carbocycle" or a "non-aromatic heterocycle" is substituted with "oxo", it means a ring in which two hydrogen atoms on a carbon atom are replaced as follows:

[0039] Substituents for "substituted amino", "substituted imino", "substituted carbamoyl" and "substituted sulfamoyl" include the following Substituent Group D. Each group may be substituted with one or two groups selected from Substituent Group D. Substituent group D: halogen, hydroxy, carboxy, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, carbamoyl optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β,Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic carbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ', aromatic heterocyclic carbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ'.

[0040] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３ and R ４ Examples of the substituent of the "substituted alkyloxy" in the formula (I) include halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; non-aromatic carbocyclic group optionally substituted with substituent group γ'; non-aromatic heterocyclic group optionally substituted with substituent group γ'; aromatic carbocyclic oxy optionally substituted with substituent group γ; aromatic heterocyclic oxy optionally substituted with substituent group γ; non-aromatic carbocyclic oxy optionally substituted with substituent group γ'; non-aromatic heterocyclic oxy optionally substituted with substituent group γ'. It may be substituted with one or more groups selected from these.

[0041] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３ and R ４Examples of the substituent of the "substituted alkyloxy" in the formula (I) include: halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0042] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３ and R ４ Examples of the substituent of the "substituted alkyloxy" in the formula (I) include: halogen; cyano; nitro; hydroxy; carboxy; alkyloxy which may be substituted with substituent group α; amino which may be substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0043] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３and R ４ In the above formula, examples of the substituents of the "substituted alkyloxy" include: halogen; cyano; nitro; hydroxy; and it may be substituted with one or more groups selected from these.

[0044] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３ and R ４ In the above formula, examples of the substituents of the "substituted alkyloxy" include: halogen; cyano; and it may be substituted with one or more groups selected from these.

[0045] R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ and R ９ｂ "Substituted alkyl" in R １ , R ２ , R ３ and R ４ In the above formula, examples of the substituents of the "substituted alkyloxy" include: halogen; and it may be substituted with one or more groups selected from these.

[0046] R １ , R ２ , R ３ and R ４Examples of the substituents of "substituted alkenyl", "substituted alkynyl", "substituted alkenyloxy" and "substituted alkynyloxy" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; non-aromatic carbocyclic group optionally substituted with substituent group γ'; non-aromatic heterocyclic group optionally substituted with substituent group γ'; aromatic carbocyclic oxy optionally substituted with substituent group γ; aromatic heterocyclic oxy optionally substituted with substituent group γ; and non-aromatic carbocyclic oxy optionally substituted with a substituent group γ'; and non-aromatic heterocyclic oxy optionally substituted with a substituent group γ'. The group may be substituted with one or more groups selected from these.

[0047] R １ , R ２ , R ３ and R ４ In the formula (I), examples of the substituents of "substituted alkenyl", "substituted alkynyl", "substituted alkenyloxy" and "substituted alkynyloxy" include: halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0048] R １, R ２ , R ３ and R ４ In the above, examples of the substituents of "substituted alkenyl", "substituted alkynyl", "substituted alkenyloxy" and "substituted alkynyloxy" include: halogen; cyano; nitro; hydroxy; carboxy; alkyloxy which may be substituted with substituent group α; amino which may be substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0049] R １ , R ２ , R ３ and R ４ In the above, examples of the substituents of "substituted alkenyl", "substituted alkynyl", "substituted alkenyloxy" and "substituted alkynyloxy" include halogen, cyano, nitro, and hydroxy. The group may be substituted with one or more groups selected from these.

[0050] R １ , R ２ , R ３ and R ４ In the above, examples of the substituents of "substituted alkenyl", "substituted alkynyl", "substituted alkenyloxy" and "substituted alkynyloxy" include halogen; cyano; and may be substituted with one or more groups selected from these.

[0051] R ９ａ and R ９ｂExamples of the substituents of the "substituted aromatic carbocyclic group" and "substituted aromatic heterocyclic group" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; non-aromatic carbocyclic group optionally substituted with substituent group γ'; Examples include: a non-aromatic heterocyclic group optionally substituted with a substituent group γ'; an aromatic carbocyclic oxy optionally substituted with a substituent group γ; an aromatic heterocyclic oxy optionally substituted with a substituent group γ; a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ'; and a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ'. It may be substituted with one or more groups selected from these.

[0052] R ９ａ and R ９ｂExamples of the substituents of the "substituted aromatic carbocyclic group" and "substituted aromatic heterocyclic group" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and optionally substituted with one or more groups selected from these.

[0053] R ９ａ and R ９ｂ Examples of the substituents of the "substituted aromatic carbocyclic group" and "substituted aromatic heterocyclic group" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; amino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and optionally substituted with one or more groups selected from these.

[0054] R ９ａ and R ９ｂExamples of the substituents of the "substituted aromatic carbocyclic group" and "substituted aromatic heterocyclic group" in the above formula include: halogen; cyano; nitro; hydroxy; carboxy; alkyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; and may be substituted with one or more groups selected from these.

[0055] R ９ａ and R ９ｂ Examples of the substituents of the "substituted aromatic carbocyclic group" and "substituted aromatic heterocyclic group" in the above formula include: halogen; cyano; alkyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; and may be substituted with one or more groups selected from these.

[0056] R ９ａ and R ９ｂExamples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula (1) include halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; Examples include: a non-aromatic carbocyclic group optionally substituted with a substituent group γ'; a non-aromatic heterocyclic group optionally substituted with a substituent group γ'; an aromatic carbocyclic oxy optionally substituted with a substituent group γ; an aromatic heterocyclic oxy optionally substituted with a substituent group γ; a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ'; and a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ'. It may be substituted with one or more groups selected from these.

[0057] R ９ａ and R ９ｂExamples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and optionally substituted with one or more groups selected from these.

[0058] R ９ａ and R ９ｂ Examples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; amino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and optionally substituted with one or more groups selected from these.

[0059] R ９ａ and R ９ｂExamples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula include: halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; and optionally substituted with one or more groups selected from these.

[0060] R ９ａ and R ９ｂ Examples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula include: halogen; cyano; oxo; alkyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; and optionally substituted with one or more groups selected from these.

[0061] R ７ａ and R ９ａand R 1 and R 2 are each independently substituted with a carbon atom to which they are bonded. Examples of the substituents of the "substituted non-aromatic heterocycle", "substituted 5- to 7-membered non-aromatic heterocycle", "substituted 6-membered non-aromatic heterocycle" and "substituted piperidine" which each of these groups forms together with the carbon atom to which it is bonded include: halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl which may be substituted by substituent group α; alkenyl which may be substituted by substituent group α; alkynyl which may be substituted by substituent group α; alkyloxy which may be substituted by substituent group α; alkenyloxy which may be substituted by substituent group α; alkynyloxy which may be substituted by substituent group α; alkylcarbonyl which may be substituted by substituent group α; alkyloxycarbonyl which may be substituted by substituent group α; alkylsulfonyl which may be substituted by substituent group α; sulfamoyl which may be substituted by substituent group β; amino which may be substituted by substituent group β; imino which may be substituted by substituent group β; carbamoyl which may be substituted by substituent group β; aromatic carbocyclic group which may be substituted by substituent group γ; Examples include an aromatic heterocyclic group optionally substituted with substituent group γ; a non-aromatic carbocyclic group optionally substituted with substituent group γ'; a non-aromatic heterocyclic group optionally substituted with substituent group γ'; an aromatic carbocyclic oxy optionally substituted with substituent group γ; an aromatic heterocyclic oxy optionally substituted with substituent group γ; a non-aromatic carbocyclic oxy optionally substituted with substituent group γ'; a non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; and a non-aromatic heterocyclic oxy optionally substituted with substituent group γ'. It may be substituted with one or more groups selected from these.

[0062] R ７ａ and R ９ａare taken together with the carbon atoms to which they are bonded to form the "substituted non-aromatic heterocycle", "substituted 5- to 7-membered non-aromatic heterocycle", "substituted 6-membered non-aromatic heterocycle" and "substituted piperidine", for example, halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β. It may be substituted with one or more groups selected from these.

[0063] R ７ａ and R ９ａ are taken together with the carbon atoms to which they are bonded to form the "substituted non-aromatic heterocycle", "substituted 5- to 7-membered non-aromatic heterocycle", "substituted 6-membered non-aromatic heterocycle" and "substituted piperidine". Examples of the substituents include: halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; amino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β. It may be substituted with one or more groups selected from these.

[0064] R ７ａ and R ９ａare taken together with the carbon atoms to which they are bonded to form the "substituted non-aromatic heterocycle", "substituted 5- to 7-membered non-aromatic heterocycle", "substituted 6-membered non-aromatic heterocycle" and "substituted piperidine", for example, halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl which may be substituted with substituent group α; alkyloxy which may be substituted with substituent group α; and may be substituted with one or more groups selected from these.

[0065] R ７ａ and R ９ａ are taken together with the carbon atoms to which they are bonded to form the "substituted non-aromatic heterocycle", "substituted 5- to 7-membered non-aromatic heterocycle", "substituted 6-membered non-aromatic heterocycle" and "substituted piperidine", for example, halogen; cyano; oxo; alkyl which may be substituted with substituent group α; alkyloxy which may be substituted with substituent group α; and may be substituted with one or more groups selected from these.

[0066] R ７ａ and R ９ａ are taken together with the carbon atoms to which they are bonded to form a "substituted non-aromatic heterocycle", a "substituted 5- to 7-membered non-aromatic heterocycle", a "substituted 6-membered non-aromatic heterocycle" and a "substituted piperidine", for example, halogen; oxo; They may be substituted with one or more groups selected from these.

[0067] R ５ Examples of the substituents of the "substituted aromatic carbocyclic group", "substituted phenyl" and "substituted aromatic heterocyclic group" in the above formula (I) include those in the substituent group B. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group B. ５Examples of the substituents of the "substituted aromatic carbocyclic group", "substituted phenyl" and "substituted aromatic heterocyclic group" in the above formula include halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ',Aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', Optionally substituted non-aromatic heterocyclyl alkyloxyalkyl, aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclyl sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclyl sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfanyl optionally substituted with substituent group γ,Examples include non-aromatic heterocyclic alkylsulfanyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted with a substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted with a substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', non-aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group B. R, ５Examples of the substituents of the "substituted aromatic carbocyclic group", "substituted phenyl" and "substituted aromatic heterocyclic group" in the above formula (I) include halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic carbocyclic-haloalkyl optionally substituted with a substituent group γ,Non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ ring sulfinyl, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ',Examples of the alkylsulfonyl include aromatic carbocyclic alkylsulfonyl which may be substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl which may be substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl which may be substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl which may be substituted with substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from substituent group B. R, ５Examples of the substituents of the "substituted aromatic carbocyclic group", "substituted phenyl" and "substituted aromatic heterocyclic group" in the above formula (I) include halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', substituted aromatic carbocyclic alkenyl optionally substituted with group γ, non-aromatic carbocyclic alkenyl optionally substituted with substituent group γ', aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ,Non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ' Examples thereof include aromatic carbocyclic sulfinyl, aromatic heterocyclic sulfinyl optionally substituted with a substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with a substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with a substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ and non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group B. R, ５Examples of the substituents of the "substituted aromatic carbocyclic group", "substituted phenyl" and "substituted aromatic heterocyclic group" in the above formula include halogen, cyano, alkyl which may be substituted with substituent group α, alkyloxy which may be substituted with substituent group α, amino which may be substituted with substituent group β, Examples thereof include an aromatic carbocyclic group optionally substituted with substituent group γ, an aromatic heterocyclic group optionally substituted with substituent group γ, a non-aromatic heterocyclic group optionally substituted with substituent group γ', an aromatic carbocyclic oxy optionally substituted with substituent group γ, a non-aromatic carbocyclic oxy optionally substituted with substituent group γ', an aromatic heterocyclic oxy optionally substituted with substituent group γ, an aromatic carbocyclic alkyl optionally substituted with substituent group γ, an aromatic carbocyclic alkenyl optionally substituted with substituent group γ, an aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', an aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, an aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, and an aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ. An atom at any position on the ring may be bonded to one or more groups selected from Substituent Group B.

[0068] R ５ Examples of the substituents of the "substituted non-aromatic carbocyclic group" and "substituted non-aromatic heterocyclic group" in the above formula include those in the substituent group C. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group C. ５Examples of the substituents of the "substituted non-aromatic carbocyclic group" and the "substituted non-aromatic heterocyclic group" in the above formula include halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, oxo, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ',Aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', Optionally substituted non-aromatic heterocyclyl alkyloxyalkyl, aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclyl sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclyl sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfanyl optionally substituted with substituent group γ,Examples include non-aromatic heterocyclic alkylsulfanyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted with a substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted with a substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', non-aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group B. R, ５Examples of the substituents of the "substituted non-aromatic carbocyclic group" and the "substituted non-aromatic heterocyclic group" in the above formula (I) include halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, oxo, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic carbocyclic-haloalkyl optionally substituted with a substituent group γ,Non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ ring sulfinyl, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ',Examples of the alkylsulfonyl include aromatic carbocyclic alkylsulfonyl which may be substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl which may be substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl which may be substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl which may be substituted with substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from substituent group B. R, ５Examples of the substituents of the "substituted non-aromatic carbocyclic group" and the "substituted non-aromatic heterocyclic group" in the above formula include halogen, cyano, nitro, oxo, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', substituted aromatic carbocyclic alkenyl optionally substituted with group γ, non-aromatic carbocyclic alkenyl optionally substituted with substituent group γ', aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ,Non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ' Examples thereof include aromatic carbocyclic sulfinyl, aromatic heterocyclic sulfinyl optionally substituted with a substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with a substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with a substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with a substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with a substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ and non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ'. An atom at any position on the ring may be bonded to one or more groups selected from the substituent group B. R, ５Examples of the substituents of the "substituted non-aromatic carbocyclic group" and the "substituted non-aromatic heterocyclic group" in the above formula include halogen, cyano, alkyl which may be substituted with substituent group α, alkyloxy which may be substituted with substituent group α, amino which may be substituted with substituent group β, Examples thereof include an aromatic carbocyclic group optionally substituted with substituent group γ, an aromatic heterocyclic group optionally substituted with substituent group γ, a non-aromatic heterocyclic group optionally substituted with substituent group γ', an aromatic carbocyclic oxy optionally substituted with substituent group γ, a non-aromatic carbocyclic oxy optionally substituted with substituent group γ', an aromatic heterocyclic oxy optionally substituted with substituent group γ, an aromatic carbocyclic alkyl optionally substituted with substituent group γ, an aromatic carbocyclic alkenyl optionally substituted with substituent group γ, an aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', an aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, an aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, and an aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ. An atom at any position on the ring may be bonded to one or more groups selected from Substituent Group B.

[0069] L ２Examples of the substituents of "substituted alkylene" and "substituted C1-C3 alkylene" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted by substituent group α; alkylcarbonyl optionally substituted by substituent group α; alkyloxycarbonyl optionally substituted by substituent group α; alkylsulfonyl optionally substituted by substituent group α; sulfamoyl optionally substituted by substituent group β; amino optionally substituted by substituent group β; imino optionally substituted by substituent group β; carbamoyl optionally substituted by substituent group β; aromatic carbocyclic group optionally substituted by substituent group γ; aromatic heterocyclic group optionally substituted by substituent group γ; non-aromatic carbocyclic group optionally substituted by substituent group γ'; non-aromatic heterocyclic group optionally substituted by substituent group γ'; aromatic carbocyclic oxy optionally substituted by substituent group γ; aromatic heterocyclic oxy optionally substituted by substituent group γ; non-aromatic carbocyclic oxy optionally substituted by substituent group γ'; and non-aromatic heterocyclic oxy optionally substituted with a substituent group γ′. It may be substituted with one or more groups selected from these.

[0070] L ２ Examples of the substituents of "substituted alkylene" and "substituted C1-C3 alkylene" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; alkyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; non-aromatic carbocyclic group optionally substituted with substituent group γ'; non-aromatic heterocyclic group optionally substituted with substituent group γ'; aromatic carbocyclic oxy optionally substituted with substituent group γ; aromatic heterocyclic oxy optionally substituted with substituent group γ; non-aromatic carbocyclic oxy optionally substituted with substituent group γ'; non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; and it may be substituted with one or more groups selected from these.

[0071] L２ In the above, examples of the substituents of "substituted alkylene" and "substituted C1-C3 alkylene" include halogen; cyano; nitro; alkyloxy optionally substituted with substituent group α; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; non-aromatic carbocyclic group optionally substituted with substituent group γ'; non-aromatic heterocyclic group optionally substituted with substituent group γ'; aromatic carbocyclic oxy optionally substituted with substituent group γ; aromatic heterocyclic oxy optionally substituted with substituent group γ; non-aromatic carbocyclic oxy optionally substituted with substituent group γ'; non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; and it may be substituted with one or more groups selected from these.

[0072] L ２ In the above, examples of the substituents of "substituted alkylene" and "substituted C1-C3 alkylene" include: halogen; cyano; nitro; alkyloxy optionally substituted with substituent group α; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic heterocyclic group optionally substituted with substituent group γ; aromatic carbocyclic oxy optionally substituted with substituent group γ; aromatic heterocyclic oxy optionally substituted with substituent group γ; It may be substituted with one or more groups selected from these.

[0073] L ２ In the above, examples of the substituents of "substituted alkylene" and "substituted C1-C3 alkylene" include: halogen; cyano; nitro; aromatic carbocyclic group optionally substituted with substituent group γ; aromatic carbocyclic oxy optionally substituted with substituent group γ; and it may be substituted with one or more groups selected from these.

[0074] L ２ In the above, examples of the substituents of the "substituted alkylene" and "substituted C1-C3 alkylene" include: halogen; aromatic carbocyclic groups optionally substituted with substituent group γ; and may be substituted with one or more groups selected from these.

[0075] L ２Examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and the "substituted 3- to 6-membered non-aromatic carbocyclic diyl" in the above formula (1) include halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl which may be substituted with substituent group α; alkenyl which may be substituted with substituent group α; alkynyl which may be substituted with substituent group α; alkyloxy which may be substituted with substituent group α; alkenyloxy which may be substituted with substituent group α; alkynyloxy which may be substituted with substituent group α; alkylcarbonyl which may be substituted with substituent group α; alkyloxycarbonyl which may be substituted with substituent group α; alkylsulfonyl which may be substituted with substituent group α; sulfamoyl which may be substituted with substituent group β; amino which may be substituted with substituent group β; imino which may be substituted with substituent group β; carbamoyl which may be substituted with substituent group β; aromatic carbocyclic group which may be substituted with substituent group γ; aromatic heterocyclic group which may be substituted with substituent group γ; Examples include: a non-aromatic carbocyclic group optionally substituted with a substituent group γ'; a non-aromatic heterocyclic group optionally substituted with a substituent group γ'; an aromatic carbocyclic oxy optionally substituted with a substituent group γ; an aromatic heterocyclic oxy optionally substituted with a substituent group γ; a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ'; and a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ'. It may be substituted with one or more groups selected from these.

[0076] L ２Examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and "substituted 3- to 6-membered non-aromatic carbocyclic diyl" in the above formula include halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; alkylsulfonyl optionally substituted with substituent group α; sulfamoyl optionally substituted with substituent group β; amino optionally substituted with substituent group β; imino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0077] L ２ In the above, examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and the "substituted 3- to 6-membered non-aromatic carbocyclic diyl" include: halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl optionally substituted with substituent group α; alkenyl optionally substituted with substituent group α; alkynyl optionally substituted with substituent group α; alkyloxy optionally substituted with substituent group α; alkenyloxy optionally substituted with substituent group α; alkynyloxy optionally substituted with substituent group α; alkylcarbonyl optionally substituted with substituent group α; alkyloxycarbonyl optionally substituted with substituent group α; amino optionally substituted with substituent group β; carbamoyl optionally substituted with substituent group β; and it may be substituted with one or more groups selected from these.

[0078] L ２In the above, examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and the "substituted 3- to 6-membered non-aromatic carbocyclic diyl" include: halogen; cyano; nitro; hydroxy; carboxy; oxo; alkyl which may be substituted with substituent group α; alkyloxy which may be substituted with substituent group α; and it may be substituted with one or more groups selected from these.

[0079] L ２ In the above, examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and the "substituted 3- to 6-membered non-aromatic carbocyclic diyl" include: halogen; cyano; oxo; alkyl which may be substituted with substituent group α; alkyloxy which may be substituted with substituent group α; and it may be substituted with one or more groups selected from these.

[0080] L ２ In the above, examples of the substituents of the "substituted non-aromatic carbocyclic diyl" and the "substituted 3- to 6-membered non-aromatic carbocyclic diyl" include halogen; oxo; and may be substituted with one or more groups selected from these.

[0081] In the compound of formula (I), R １ , R ２ , R ３ , R ４ , R ５ , R ６ａ , R ６ｂ , R ７ａ , R ７ｂ , R ８ａ , R ８ｂ , R ９ａ , R ９ｂ , R １０ , R １１ , R １２ , R １３ , R １４ , L １ , L ２ Preferred embodiments of Z are shown below: The compounds represented by formula (I) include all combinations of the specific examples shown below.

[0082] R １is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted alkyloxy group, a substituted or unsubstituted alkenyloxy group, or a substituted or unsubstituted alkynyloxy group (hereinafter referred to as A-1). １ is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted alkyloxy group (hereinafter referred to as A-2). １ is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy (hereinafter referred to as A-3). １ is a hydrogen atom, halogen, substituted or unsubstituted C1-C3 alkyl, or cyano (hereinafter referred to as A-4). １ is a hydrogen atom, a halogen atom, or a cyano group (hereinafter referred to as A-5). １ is a hydrogen atom or a halogen atom (hereinafter referred to as A-6). １ is a halogen. (Hereinafter referred to as A-7)

[0083] R ２ is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted alkyloxy group, a substituted or unsubstituted alkenyloxy group, or a substituted or unsubstituted alkynyloxy group (hereinafter referred to as B-1). ２ is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted alkyloxy group (hereinafter referred to as B-2). ２ is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy (hereinafter referred to as B-3). ２ is a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group (hereinafter referred to as B-4). ２ is a hydrogen atom, halogen, cyano, or substituted or unsubstituted C1-C3 alkyl (hereinafter referred to as B-5).２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl (hereinafter referred to as B-6). ２ is a hydrogen atom or a halogen atom (hereinafter referred to as B-7).

[0084] R ３ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy, provided that Z is -CR ８ａ R ８ｂ - is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy. (Hereinafter referred to as C-1) R ３ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy (provided that Z is -CR ８ａ R ８ｂ -, it is halogen, cyano, substituted or unsubstituted alkyl, or substituted or unsubstituted alkyloxy. (Hereinafter referred to as C-2) R ３ is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy (provided that Z is -CR ８ａ R ８ｂ -, it is halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy) (hereinafter referred to as C-3). ３ is a hydrogen atom, a halogen atom, or a substituted or unsubstituted alkyloxy (provided that Z is -CR ８ａ R ８ｂ -, it is halogen, or substituted or unsubstituted alkyloxy. (Hereinafter referred to as C-4) R ３is a hydrogen atom, a halogen atom, or a substituted or unsubstituted C1-C3 alkyloxy (provided that Z is -CR ８ａ R ８ｂ -, it is halogen or substituted or unsubstituted C1-C3 alkyloxy) (hereinafter referred to as C-5) R ３ is halogen, or substituted or unsubstituted C1-C3 alkyloxy (hereinafter referred to as C-6). ３ is a substituted or unsubstituted C1-C3 alkyloxy (hereinafter referred to as C-7).

[0085] R ４ is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted alkyloxy group, a substituted or unsubstituted alkenyloxy group, or a substituted or unsubstituted alkynyloxy group (hereinafter referred to as D-1). ４ is a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted alkyloxy group (hereinafter referred to as D-2). ４ is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy (hereinafter referred to as D-3). ４ is a hydrogen atom or a halogen atom. (Hereinafter referred to as D-4) ４ is a hydrogen atom (hereinafter referred to as D-5).

[0086] R ５ is a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group (hereinafter referred to as E-1). ５ is a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, or a substituted or unsubstituted aromatic heterocyclic group (hereinafter referred to as E-2). ５is a substituted or unsubstituted aromatic carbocyclic group or a substituted or unsubstituted aromatic heterocyclic group (hereinafter referred to as E-3). ５ is a substituted or unsubstituted aromatic carbocyclic group (hereinafter referred to as E-4). ５ is a substituted or unsubstituted phenyl (hereinafter referred to as E-5). ５ is the formula: (In the formula, R １０ , R １１ , R １２ , R １３ , and R １４are each independently a hydrogen atom, halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, cyano, nitro, nitroso, azido, hydrazino, ureido, amidino, guanidino, pentafluorothio, trialkylsilyl, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylcarbonyloxy optionally substituted with substituent group α, alkenylcarbonyloxy optionally substituted with substituent group α, alkynylcarbonyloxy optionally substituted with substituent group α, alkylcarbonyl optionally substituted with substituent group α, alkenylcarbonyl optionally substituted with substituent group α, alkynylcarbonyl optionally substituted with substituent group α, substituted with substituent group α alkyloxycarbonyl optionally substituted with substituent group α, alkenyloxycarbonyl optionally substituted with substituent group α, alkynyloxycarbonyl optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, carbamoyl optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ',Aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic carbonyloxy optionally substituted with substituent group γ', aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic carbonyloxy optionally substituted with substituent group γ', Aromatic carbocyclic carbonyl optionally substituted with substituent group γ', non-aromatic carbocyclic carbonyl optionally substituted with substituent group γ, aromatic heterocyclic carbonyl optionally substituted with substituent group γ', non-aromatic heterocyclic carbonyl optionally substituted with substituent group γ', aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic carbocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic oxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyl optionally substituted with substituent group γ, aromatic heterocyclic alkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkenyl optionally substituted with substituent group γ', aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ,Non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxycarbonyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, optionally substituted with substituent group γ' non-aromatic heterocyclic sulfanyl, aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ,non-aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ') (hereinafter referred to as E-6).

[0087] R ６ａ and R ６ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group (hereinafter referred to as F-1). ６ａ and R ６ｂ are each independently a hydrogen atom or a halogen atom (hereinafter referred to as F-2). ６ａ and R ６ｂ is a hydrogen atom (hereinafter referred to as F-3).

[0088] R ７ａ and R ７ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group (hereinafter referred to as G-1). ７ａ and R ７ｂ are each independently a hydrogen atom or a halogen atom (hereinafter referred to as G-2). ７ａ and R ７ｂ is a hydrogen atom. (Hereinafter referred to as G-3)

[0089] R ８ａ and R ８ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group (hereinafter referred to as H-1). ８ａ and R ８ｂ are each independently a hydrogen atom or a halogen (hereinafter referred to as H-2). ８ａ and R ８ｂ is a hydrogen atom (hereinafter referred to as H-3).

[0090] R ９ａ and R ９ｂare each independently a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group (hereinafter referred to as I-1). ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group (hereinafter referred to as I-2). ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted C1-C3 alkyl group (hereinafter referred to as I-3). ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, or a substituted or unsubstituted C1-C3 alkyl (hereinafter referred to as I-4). ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, or a methyl group (hereinafter referred to as I-5). ９ａ and R ９ｂ are each independently a hydrogen atom or a substituted or unsubstituted C1-C3 alkyl (hereinafter referred to as I-6). ９ａ and R ９ｂ are each independently a hydrogen atom and methyl. (Hereinafter referred to as I-7) ９ａ and R ９ｂ is a hydrogen atom. (Hereinafter referred to as I-8)

[0091] R ７ａ and R ９ａ may form a substituted or unsubstituted non-aromatic heterocycle together with the carbon atom to which they are attached (hereinafter referred to as J-1). ７ａ and R ９ａ may form a substituted or unsubstituted 5- to 7-membered non-aromatic heterocycle together with the carbon atom to which they are attached (hereinafter referred to as J-2). ７ａ and R ９ａmay form a substituted or unsubstituted 6-membered non-aromatic heterocycle together with the carbon atom to which they are attached (hereinafter referred to as J-3). ７ａ and R ９ａ may combine with the carbon atom to which they are attached to form a substituted or unsubstituted piperidine (hereinafter referred to as J-4). ７ａ and R ９ａ may combine with the carbon atom to which they are attached to form an unsubstituted piperidine (hereinafter referred to as J-5).

[0092] R １０represents a hydrogen atom, halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted by substituent group β, imino optionally substituted by substituent group β, sulfamoyl optionally substituted by substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ', a non-aromatic carbocyclic-oxy ​​optionally substituted with a substituent group γ, an aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ, a non-aromatic heterocyclic-oxy ​​optionally substituted with a substituent group γ', an aromatic carbocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkyl optionally substituted with a substituent group γ', an aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic carbocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ, a non-aromatic heterocyclic-alkenyl optionally substituted with a substituent group γ', an aromatic carbocyclic-haloalkyl optionally substituted with a substituent group γ,Non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', Aromatic carbocyclic sulfanyl optionally substituted with group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfinyl optionally substituted with substituent group γ', substituted with substituent group γ aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclic sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ',aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ, and non-aromatic heterocyclic alkylsulfonyl optionally substituted with substituent group γ' (hereinafter referred to as K-1). R, １０represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkenylsulfinyl optionally substituted with substituent group α, alkynylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ' alkyl, aromatic heterocyclic alkyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkyl optionally substituted by substituent group γ', aromatic carbocyclic alkenyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkenyl optionally substituted by substituent group γ', aromatic heterocyclic alkenyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted by substituent group γ', aromatic carbocyclic haloalkyl optionally substituted by substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted by substituent group γ', aromatic heterocyclic haloalkyl optionally substituted by substituent group γ,Non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic halo Alkyloxy, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ phenyl, non-aromatic heterocyclic sulfinyl optionally substituted by substituent group γ', aromatic carbocyclic sulfonyl optionally substituted by substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted by substituent group γ', aromatic heterocyclic sulfonyl optionally substituted by substituent group γ and non-aromatic heterocyclic sulfonyl optionally substituted by substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted by substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted by substituent group γ', aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γ', aromatic heterocyclic alkylsulfinyl optionally substituted by substituent group γ, non-aromatic heterocyclic alkylsulfinyl optionally substituted by substituent group γ', aromatic carbo ...onyl optionally substituted by substituent group γ, non-aromatic carbocyclic alkylsulfinyl optionally substituted by substituent group γR is an aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ, and R is a non-aromatic heterocyclic alkylsulfonyl optionally substituted with a substituent group γ′ (hereinafter referred to as K-2). １０represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic optionally substituted with substituent group γ' ring alkenyl, aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ',Aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclyl sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl sulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ' (hereinafter referred to as K-3). １０represents a hydrogen atom, a halogen atom, an alkyl group optionally substituted with substituent group α, an alkyloxy group optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, aromatic carbocyclic alkyl optionally substituted with substituent group γ, aromatic carbocyclic alkenyl optionally substituted with substituent group γ, aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ. (Hereafter referred to as K-4)

[0093] R １１represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ' (hereinafter referred to as L-1). R, １１represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ R, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ' (hereinafter referred to as L-2). １１is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ (hereinafter referred to as L-3). R １１ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, or aromatic carbocyclic oxy optionally substituted with substituent group γ (hereinafter referred to as L-4).

[0094] R １２represents a hydrogen atom, halogen, hydroxy, sulfanyl, sulfino, sulfo, cyano, nitro, hydrazino, amidino, guanidino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkenylsulfanyl optionally substituted with substituent group α, alkynylsulfanyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ' (hereinafter referred to as M-1). R, １２represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β,Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ', non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ'. (Hereafter referred to as M-2) R １２represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ'. (Hereafter referred to as M-3) R １２is a hydrogen atom, halogen, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ' (hereinafter referred to as M-4).

[0095] R １３represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, hydrazino, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfanyl optionally substituted with substituent group α, alkylsulfinyl optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, sulfamoyl optionally substituted with substituent group β, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ,non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfanyl optionally substituted with substituent group γ', aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkylsulfanyl optionally substituted with substituent group γ' (hereinafter referred to as N-1) R, １３represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted, aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxyalkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxyalkyl optionally substituted with substituent group γ'.(Hereafter referred to as N-2) R. １３ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ (hereinafter referred to as N-3). R １３ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, or aromatic heterocyclic group optionally substituted with substituent group γ (hereinafter referred to as N-4).

[0096] R １４represents a hydrogen atom, halogen, hydroxy, sulfanyl, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ R, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ' (hereinafter referred to as O-1). １４is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ (hereinafter referred to as O-2). R １４ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, or alkynyloxy optionally substituted with substituent group α (hereinafter referred to as O-3). R １４ is a hydrogen atom, halogen, cyano, C1-C3 alkyl optionally substituted with substituent group α, or C1-C3 alkyloxy optionally substituted with substituent group α (hereinafter referred to as O-4). １４ is a hydrogen atom or halogen (hereinafter referred to as O-5).

[0097] L １ is a single bond or -CR ９ａ R ９ｂ - and; L ２ is a single bond, a substituted or unsubstituted alkylene, or a substituted or unsubstituted non-aromatic carbocyclic diyl (hereinafter referred to as P-1). １ is a single bond or -CR ９ａ R ９ｂ - and; L ２is a single bond, a substituted or unsubstituted C1-C3 alkylene, or a substituted or unsubstituted 3- to 6-membered non-aromatic carbocyclic diyl (hereinafter referred to as P-2). １ But, -CR ９ａ R ９ｂ - and; L ２ is a single bond or a substituted or unsubstituted alkylene (hereinafter referred to as P-3). １ But, -CR ９ａ R ９ｂ - and; L ２ is a single bond or a substituted or unsubstituted C1-C3 alkylene (hereinafter referred to as P-4). １ But, -CR ９ａ R ９ｂ - and; L ２ is a single bond. (Hereinafter referred to as P-5)

[0098] Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ -, -CR ８ａ R ８ｂ -, -CH=CH-, -CH=N-, or -N=CH- (hereinafter referred to as Q-1). Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ -, -CR ８ａ R ８ｂ -, -CH=CH-, or -CH=N- (hereinafter referred to as Q-2). ６ａ R ６ｂ -CR ７ａ R ７ｂ -, -CH=CH-, -CH=N-, or -N=CH- (hereinafter referred to as Q-3). ６ａ R ６ｂ -CR ７ａ R ７ｂ - (Hereafter referred to as Q-4)

[0099] The compound of the present invention is particularly preferably represented by the following formulas (i) to (ix): (i) Formula (I): (Wherein, Z is —CR ６ａ R ６ｂ -CR ７ａ R ７ｂ- and R ６ａ and R ６ｂ is a hydrogen atom; R ７ａ and R ７ｂ is a hydrogen atom; R １ is a hydrogen atom, a halogen atom, or a cyano; R ２ is a hydrogen atom, halogen, cyano, or substituted or unsubstituted C1-C3 alkyl; R ３ is a hydrogen atom, halogen, or substituted or unsubstituted C1-C3 alkyloxy; R ４ is a hydrogen atom or a halogen; １ is -CR ９ａ R ９ｂ - and R ９ａ and R ９ｂ is a hydrogen atom; ２ is a single bond; R ５ is a substituted or unsubstituted aromatic carbocyclic group, or a substituted or unsubstituted aromatic heterocyclic group), or a pharmaceutically acceptable salt thereof.

[0100] (ii) R １ is a hydrogen atom or a halogen; R ２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl; R ４ is a hydrogen atom, or a pharmaceutically acceptable salt thereof.

[0101] (iii) R ５ is substituted or unsubstituted phenyl, or a pharmaceutically acceptable salt thereof.

[0102] (iv) R １ is a hydrogen atom or a halogen; R ２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl; R ４ is a hydrogen atom; R ５ is substituted or unsubstituted phenyl, or a pharmaceutically acceptable salt thereof.

[0103] (v) R ５ But the formula: (In the formula, R１０represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic optionally substituted with substituent group γ' ring alkenyl, aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ',Aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclylsulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ'; R, １１ is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １２represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic oxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ, an aromatic heterocyclic oxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ', an aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ, an aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', an aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １４ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α), or a pharmaceutically acceptable salt thereof.

[0104] (vi) R ５ But the formula: (In the formula, R １０represents a hydrogen atom, a halogen atom, an alkyl group optionally substituted with substituent group α, an alkyloxy group optionally substituted with substituent group α, an aromatic carbocyclic group optionally substituted with substituent group γ, an aromatic heterocyclic group optionally substituted with substituent group γ, a non-aromatic heterocyclic group optionally substituted with substituent group γ', an aromatic carbocyclic oxy optionally substituted with substituent group γ, a non-aromatic carbocyclic oxy optionally substituted with substituent group γ', an aromatic heterocyclic oxy optionally substituted with substituent group γ, an aromatic carbocyclic alkyl optionally substituted with substituent group γ, an aromatic carbocyclic alkenyl optionally substituted with substituent group γ, an aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', an aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, an aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, an aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ; R １１ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, aromatic carbocyclic oxy optionally substituted with substituent group γ; R １２ is a hydrogen atom, halogen, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, aromatic heterocyclic group optionally substituted with substituent group γ; R １４ is a hydrogen atom or a halogen), or a pharmaceutically acceptable salt thereof.

[0105] (vii) R １ is a hydrogen atom or a halogen; R ２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl; R ４ is a hydrogen atom; R ５ But the formula: (In the formula, R １０represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic optionally substituted with substituent group γ' ring alkenyl, aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ',Aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclylsulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ'; R, １１ is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １２represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic oxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ, an aromatic heterocyclic oxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ', an aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ, an aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', an aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １４ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α), or a pharmaceutically acceptable salt thereof.

[0106] (viii) R １ is a hydrogen atom or a halogen; R ２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl; R ４ is a hydrogen atom; R ５ But the formula: (In the formula, R １０represents a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, alkylsulfonyl optionally substituted with substituent group α, alkenylsulfonyl optionally substituted with substituent group α, alkynylsulfonyl optionally substituted with substituent group α, Aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ', aromatic carbocyclic alkyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkyl optionally substituted with substituent group γ', aromatic heterocyclic alkyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkyl optionally substituted with substituent group γ', aromatic carbocyclic alkenyl optionally substituted with substituent group γ, non-aromatic carbocyclic optionally substituted with substituent group γ' ring alkenyl, aromatic heterocyclic alkenyl optionally substituted with substituent group γ, non-aromatic heterocyclic alkenyl optionally substituted with substituent group γ', aromatic carbocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyl optionally substituted with substituent group γ', aromatic heterocyclic haloalkyl optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyl optionally substituted with substituent group γ', aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ',Aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic haloalkyloxy optionally substituted with substituent group γ', aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfanyl optionally substituted with substituent group γ', aromatic heterocyclic sulfanyl optionally substituted with substituent group γ, non-aromatic heterocyclic sulfanyl optionally substituted with substituent group γ', aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfinyl optionally substituted with substituent group γ', aromatic heterocyclic sulfinyl optionally substituted with substituent group γ, non-aromatic heterocyclylsulfinyl optionally substituted with substituent group γ, non-aromatic carbocyclic sulfonyl optionally substituted with substituent group γ', aromatic heterocyclylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclylsulfonyl optionally substituted with substituent group γ', aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ, non-aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ', aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ and non-aromatic heterocyclyl alkylsulfonyl optionally substituted with substituent group γ'; R, １１ is a hydrogen atom, halogen, cyano, nitro, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １２represents a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, imino optionally substituted with substituent group β, an aromatic carbocyclic group optionally substituted with a substituent group γ, a non-aromatic carbocyclic group optionally substituted with a substituent group γ', an aromatic heterocyclic group optionally substituted with a substituent group γ, a non-aromatic heterocyclic group optionally substituted with a substituent group γ', an aromatic carbocyclic oxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic oxy optionally substituted with a substituent group γ, an aromatic heterocyclic oxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic oxy optionally substituted with a substituent group γ', an aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic alkyloxy optionally substituted with a substituent group γ, an aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with a substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', a non-aromatic carbocyclic haloalkyloxy optionally substituted with a substituent group γ', an aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ, a non-aromatic heterocyclic haloalkyloxy optionally substituted with a substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkenyl optionally substituted with substituent group α, alkynyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, alkenyloxy optionally substituted with substituent group α, alkynyloxy optionally substituted with substituent group α, aromatic carbocyclic group optionally substituted with substituent group γ, non-aromatic carbocyclic group optionally substituted with substituent group γ', aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic heterocyclic oxy optionally substituted with substituent group γ'; R １４ is a hydrogen atom, halogen, cyano, C1-C3 alkyl optionally substituted with substituent group α, or C1-C3 alkyloxy optionally substituted with substituent group α), or a pharmaceutically acceptable salt thereof.

[0107] (ix) R １ is a hydrogen atom or a halogen; R ２ is a hydrogen atom, halogen, cyano, or unsubstituted methyl; R ４ is a hydrogen atom; R ５ But the formula: (In the formula, R １０represents a hydrogen atom, a halogen atom, an alkyl group optionally substituted with substituent group α, an alkyloxy group optionally substituted with substituent group α, an aromatic carbocyclic group optionally substituted with substituent group γ, an aromatic heterocyclic group optionally substituted with substituent group γ, a non-aromatic heterocyclic group optionally substituted with substituent group γ', an aromatic carbocyclic oxy optionally substituted with substituent group γ, a non-aromatic carbocyclic oxy optionally substituted with substituent group γ', an aromatic heterocyclic oxy optionally substituted with substituent group γ, an aromatic carbocyclic alkyl optionally substituted with substituent group γ, an aromatic carbocyclic alkenyl optionally substituted with substituent group γ, an aromatic carbocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', an aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, a non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ', an aromatic carbocyclic haloalkyloxy optionally substituted with substituent group γ, an aromatic carbocyclic sulfanyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfinyl optionally substituted with substituent group γ, an aromatic carbocyclic sulfonyl optionally substituted with substituent group γ, an aromatic carbocyclic alkylsulfonyl optionally substituted with substituent group γ; R １１ is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, aromatic carbocyclic oxy optionally substituted with substituent group γ; R １２ is a hydrogen atom, halogen, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, amino optionally substituted with substituent group β, aromatic heterocyclic group optionally substituted with substituent group γ, non-aromatic heterocyclic group optionally substituted with substituent group γ', aromatic carbocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic oxy optionally substituted with substituent group γ', aromatic heterocyclic oxy optionally substituted with substituent group γ, non-aromatic carbocyclic alkyloxy optionally substituted with substituent group γ', aromatic heterocyclic alkyloxy optionally substituted with substituent group γ, non-aromatic heterocyclic alkyloxy optionally substituted with substituent group γ'; R １３is a hydrogen atom, halogen, cyano, alkyl optionally substituted with substituent group α, alkyloxy optionally substituted with substituent group α, aromatic heterocyclic group optionally substituted with substituent group γ; R １４ is a hydrogen atom or a halogen), or a pharmaceutically acceptable salt thereof.

[0108] The compound represented by formula (I) is not limited to a particular isomer, and includes all possible isomers (e.g., keto-enol isomers, imine-enamine isomers, diastereoisomers, optical isomers, rotamers, tautomers as described below, etc.), racemates, or mixtures thereof.

[0109] One or more hydrogen, carbon and / or other atoms of the compounds of formula (I) may be replaced by isotopes of the respective hydrogen, carbon and / or other atoms. Examples of such isotopes include: ２ H. ３ H. １１ C. １３ C. １４ C. １５ N. １８ O. １７ O. ３１ P. ３２ P. ３５ S. １８ F. 123 I and ３６ The isotopes of the compounds of formula (I) include hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, iodine, and chlorine, such as Cl. The compounds of formula (I) also include compounds substituted with such isotopes. The isotope-substituted compounds are also useful as pharmaceuticals. The compounds of formula (I) include all radiolabeled compounds substituted with radioactive isotopes contained in the isotopes. Also included in the present invention is a "radiolabeling method" for producing the "radiolabeled compound," and the "radiolabeled compound" is useful as a research and / or diagnostic tool in metabolism pharmacokinetic studies and binding assays.

[0110] Radiolabeled compounds of formula (I) can be prepared by methods well known in the art. For example, tritium-labeled compounds of formula (I) can be prepared by introducing tritium into a specific compound of formula (I) via catalytic dehalogenation using tritium. This method involves reacting a suitable halogen-substituted precursor of formula (I) with tritium gas in the presence of a suitable catalyst, such as Pd / C, in the presence or absence of a base. Other suitable methods for preparing tritium-labeled compounds can be found in "Isotopes in the Physical and Biomedical Sciences, Vol. 1, Labeled Compounds (Part A), Chapter 6 (1987)." １４ C-labeled compounds are １４ It can be prepared by using a raw material having C carbon.

[0111] Pharmaceutically acceptable salts of the compound represented by formula (I) include, for example, salts of the compound represented by formula (I) with alkali metals (e.g., lithium, sodium, potassium, etc.), alkaline earth metals (e.g., calcium, barium, etc.), magnesium, transition metals (e.g., zinc, iron, etc.), ammonia, organic bases (e.g., trimethylamine, triethylamine, dicyclohexylamine, ethanolamine, diethanolamine, triethanolamine, meglumine, ethylenediamine, pyridine, picolinic acid, methylparaben ... Examples of suitable salts include salts with carboxylic acids (e.g., carboxylic acids such as carboxylic acids, ...

[0112] The present invention includes the following forms. (i) The compound represented by formula (I) of the present invention may form a salt or a co-crystal. (ii) The compound represented by formula (I) of the present invention also includes solvates (e.g., hydrates, etc.) and / or crystalline polymorphs. (iii) The pharmaceutically acceptable salt of the compound represented by formula (I) of the present invention also includes solvates (e.g., hydrates, etc.) and / or crystalline polymorphs. (iv) The co-crystal of the compound represented by formula (I) of the present invention also includes solvates (e.g., hydrates, etc.) and / or crystalline polymorphs. (v) A "solvate" may be coordinated with any number of solvent molecules (e.g., water molecules, etc.) relative to the compound represented by formula (I). (vi) When the compound represented by formula (I), a pharmaceutically acceptable salt of the compound represented by formula (I) of the present invention, or a co-crystal of the compound represented by formula (I) of the present invention is left in the air, it may absorb moisture, resulting in the formation of adsorbed water or the formation of a hydrate. (vii) A compound represented by formula (I), a pharmaceutically acceptable salt of a compound represented by formula (I) of the present invention, or a cocrystal of a compound represented by formula (I) of the present invention may be mutually converted by recrystallization. (viii) A pharmaceutically acceptable salt of a compound represented by formula (I) of the present invention refers to a compound comprising a compound represented by formula (I) and a counter molecule or counter ion, with the two being bonded via an ionic bond. (ix) A cocrystal of a compound represented by formula (I) of the present invention means that the compound represented by formula (I) and a counter molecule are present in the same crystal lattice, and may contain any number of counter molecules. (x) A cocrystal is distinguished from a salt in that the compound represented by formula (I) remains essentially uncharged or neutral. (xi) A cocrystal is distinguished from a solvate (e.g., a hydrate) in that the counter molecule is not water or a solvent. Generally, a salt is considered to undergo proton transfer between the compound and the counter molecule, but it is also known that in some cases, the proton transfer may not be complete. This state is sometimes called a cocrystal because it is not a true salt. It is also known that proton transfer can vary continuously with temperature.Therefore, as used herein, "a pharmaceutically acceptable salt of a compound of formula (I)" includes co-crystals and refers to a pharmaceutically acceptable salt or co-crystal of a compound of formula (I).

[0113] (xii) The compound of the present invention represented by formula (I) may be amorphous. (xiii) The pharmaceutically acceptable salt of the compound of the present invention represented by formula (I) may be amorphous.

[0114] The compound of formula (I) of the present invention or a pharmaceutically acceptable salt thereof may form a prodrug, and the present invention also encompasses such various prodrugs. A prodrug is a derivative of the compound of the present invention having a chemically or metabolically decomposable group, and is a compound that becomes a pharmaceutically active compound of the present invention in vivo by solvolysis or under physiological conditions. Prodrugs include compounds that are converted to the compound of formula (I) by enzymatic oxidation, reduction, hydrolysis, etc. under physiological conditions in vivo, and compounds that are converted to the compound of formula (I) by hydrolysis with gastric acid, etc. Methods for selecting and preparing appropriate prodrug derivatives are described, for example, in "Design of Prodrugs, Elsevier, Amsterdam, 1985." Prodrugs may themselves be active.

[0115] When the compound represented by formula (I) or a pharmaceutically acceptable salt thereof has a hydroxyl group, examples of the prodrug include acyloxy derivatives and sulfonyloxy derivatives produced by reacting the compound having a hydroxyl group with an appropriate acyl halide, an appropriate acid anhydride, an appropriate sulfonyl chloride, an appropriate sulfonyl anhydride, and a mixed anhydride, or by reacting the compound using a condensing agent. For example, CH ３ COO-, C ２ H ５ COO-, tert-BuCOO-, C １５ H ３１ COO-, PhCOO-, (m-NaOOCPh)COO-, NaOOCCH ２ CH ２ COO-, CH３ CH(NH ２ ) COO-, CH ２ N (CH ３ ) ２ COO-, CH ３ SO ３ -, CH ３ CH ２ SO ３ -, CF ３ SO ３ -, CH ２ FSO ３ -, CF ３ CH ２ SO ３ -, p-CH ３ O-PhSO ３ -, PhSO ３ -, p-CH ３ PhSO ３ - are listed.

[0116] The compounds according to the present invention have antimalarial activity and are therefore useful as therapeutic and / or preventive agents for malaria.

[0117] (Method for Producing the Compound of the Present Invention) The compound of formula (I) according to the present invention can be produced, for example, by the general synthesis method shown below. Extraction, purification, etc. may be carried out by treatments performed in ordinary organic chemistry experiments. The compound of the present invention can be synthesized by referring to methods known in the art.

[0118] (Method A) Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ - or -CR ８ａ R ８ｂ If - (In the formula, LG Ａ is a leaving group (chlorine atom, bromine atom, iodine atom, succinimidyl group, etc.), and PG Ａ is a protecting group for hydroxy, and other symbols are as defined above.) (Step 1) In the presence or absence of a base, compound (i ａ ) and compound (ii) ａ ) to react with compound (iii) ａThe base may be triethylamine, diisopropylethylamine, potassium carbonate, sodium carbonate, cesium carbonate, sodium hydride, or the like. ａ Compound (ii) can be used in an amount of 1 to 10 molar equivalents. ａ ) is a compound (i ａ The reaction temperature is 0°C to the reflux temperature of the solvent, preferably room temperature to 100°C. The reaction time is 0.5 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include tetrahydrofuran, 1,4-dioxane, DMF, DMA, and NMP, which can be used alone or in combination. (Step 2) In the presence of a base, compound (iii) ａ ) and a halogen to form a compound (iv ａ The base may be sodium hydrogen carbonate, sodium acetate, sodium carbonate, sodium hydroxide, or the like, and the compound (iii) can be obtained. ａ The halogen atom can be iodine, bromine, or the like. ａ ) can be used in an amount of 1 to 10 molar equivalents. The reaction temperature is 0°C to the reflux temperature of the solvent, preferably room temperature to 50°C. The reaction time is 0.1 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include tetrahydrofuran, 1,4-dioxane, DMF, DMA, NMP, DMSO, etc., which can be used alone or in combination. (Step 3) Compound (Ia) can be prepared from compound (iv) according to the method described in Greene's Protective Group in Organic Synthesis (5th Edition). ａ ) the protecting group PG Ａ The order of these steps can be changed as appropriate.

[0119] (Method B) Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ - and L １ Ga-CR ９ａ R ９ｂ - and R９ｂ When is a hydrogen atom (wherein the symbols are as defined above) (Step 1) In the presence or absence of an acid, and in the presence or absence of a base, compound (i ｂ ) and compound (ii) ｂ ) and reduced with a reducing agent to give compound (iii) ｂ The acid may be acetic acid, hydrochloric acid, sulfuric acid, or the like. ａ The base can be used in an amount of 1 to 10 molar equivalents relative to the compound (i). Examples of the base include triethylamine, diisopropylethylamine, potassium carbonate, sodium carbonate, cesium carbonate, sodium hydride, etc. ａ Compound (ii) can be used in an amount of 1 to 10 molar equivalents. ｂ ) is a compound (i ｂ The reducing agent can be used in an amount of 1 to 3 molar equivalents relative to the compound (i). Examples of the reducing agent include sodium borohydride, sodium cyanoborohydride, sodium triacetoxyborohydride, borane and its complexes, lithium borohydride, potassium borohydride, and diisobutylaluminum hydride. ｂ ) can be used in an amount of 1 to 10 molar equivalents relative to the reactant. The reaction temperature is from -78°C to the reflux temperature of the solvent, preferably 0 to 25°C. The reaction time is from 0.5 to 48 hours, preferably 1 to 6 hours. Reaction solvents include tetrahydrofuran, toluene, dichloromethane, 1,2-dichloroethane, chloroform, methanol, ethanol, 1,4-dioxane, DMF, DMA, NMP, DMSO, etc., which can be used alone or in combination. (Step 2) Compound (Ib) can be obtained in the same manner as in Step 2 of Method A.

[0120] (C method) Z is -CR ８ａ R ８ｂ - and R ８ｂ is a hydrogen atom, and L １ Ga-CR ９ａ R ９ｂ - and R ９ｂ When is a hydrogen atom (In the formula, PG Ｃis a protecting group for hydroxy, and R Ｃ is a substituted or unsubstituted alkyl, and the other symbols are as defined above.) (Step 1) Compound (iii) ｃ (Step 2) Compound (Ic) can be obtained by cleaving compound (iii) according to the method described in Greene's Protective Group in Organic Synthesis (5th edition). ｃ ) the protecting group PG Ｃ can be synthesized by removing

[0121] (Method D) When Z is -CH=CH- (In the formula, X Ｄ is a halogen, and other symbols are as defined above.) (Step 1) In the presence of AIBN, compound (i ｄ ) with a halogenating agent to obtain compound (ii) ｄ Examples of halogenating agents include N-iodosuccinimide, N-bromosuccinimide, and N-chlorosuccinimide. ａ The reaction temperature is 0°C to the reflux temperature of the solvent, preferably room temperature to 100°C. The reaction time is 0.5 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include carbon tetrachloride, chloroform, and benzene, which can be used alone or in combination. (Step 2) Compound (ii) ｄ Compound (Id) can be obtained by reacting compound (ii) with hydrogen gas in the presence of a metal catalyst. Examples of the metal catalyst include palladium-carbon, platinum oxide, and chlorotris(triphenylphosphine)rhodium(I). ｄ) can be used at 0.01 to 100 weight percent. The hydrogen pressure can be 1 to 50 atmospheres. Cyclohexene, 1,4-cyclohexadiene, formic acid, ammonium formate, etc. can also be used as the hydrogen source. The reaction temperature is 0°C to the reflux temperature of the solvent, preferably 20°C to 40°C. The reaction time is 0.5 to 72 hours, preferably 1 to 12 hours. Examples of reaction solvents include methanol, ethanol, propanol, isopropanol, butanol, tetrahydrofuran, diethyl ether, toluene, ethyl acetate, acetic acid, water, etc., and these can be used alone or in combination.

[0122] (Method E) When Z is -CH=N- (In the formula, PG Ｅ is a protecting group for hydroxy, and R Ｅ is a substituted or unsubstituted alkyl, and other symbols are as defined above.) (Step 1) In the presence or absence of a base, compound (i ｅ ) and compound (ii) ｅ ) to react with compound (iii) ｅ Compound (ii) can be obtained. ｅ ) is a compound (i ｅ The base can be used in an amount of 1 to 10 molar equivalents relative to the compound (i). Examples of the base include triethylamine, diisopropylethylamine, potassium carbonate, sodium carbonate, cesium carbonate, sodium hydride, etc. ｅ The reaction temperature is 0°C to the reflux temperature of the solvent, preferably room temperature to 100°C. The reaction time is 0.5 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include tetrahydrofuran, 1,4-dioxane, DMF, DMA, and NMP, which can be used alone or in combination. (Step 2) In the presence of an acid, compound (iii) ｅ ) to give compound (iv) ｅ The acid may be acetic acid, hydrochloric acid, sulfuric acid, or the like. ｅ) can be used in an amount of 1 to 100 molar equivalents. The reaction temperature is 0°C to the reflux temperature of the solvent, preferably room temperature to 100°C. The reaction time is 0.5 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include tetrahydrofuran, 1,4-dioxane, DMF, DMA, NMP, water, etc., which can be used alone or in combination, but do not necessarily have to be used. (Step 3) Compound (Ie) can be prepared from compound (iv) according to the method described in Greene's Protective Group in Organic Synthesis (5th Edition). ｅ ) the protecting group PG Ｅ can be synthesized by removing

[0123] (Method F) When Z is -N=CH- (In the formula, PG Ｆ is an amino-protecting group, and other symbols are as defined above.) (Step 1) In the presence of a copper catalyst, compound (i ｆ ) and compound (ii) ｆ ) to react with compound (iii) ｆ Compound (ii) can be obtained. ｆ ) is a compound (i ｆ The copper catalyst can be used in an amount of 1 to 10 molar equivalents relative to the compound (i). ｆ ) can be used in an amount of 0.01 to 5 molar equivalents. The reaction temperature is 20°C to the reflux temperature of the solvent, and in some cases, the reaction is carried out at a temperature under microwave irradiation. The reaction time is 0.1 to 48 hours, preferably 0.5 to 12 hours. Examples of reaction solvents include tetrahydrofuran, toluene, DMF, dioxane, water, etc., which can be used alone or in combination. (Step 2) Compound (If) can be prepared from compound (iii) according to the method described in Greene's Protective Group in Organic Synthesis (5th Edition). ｆ ) the protecting group PG Ｅ can be synthesized by removing

[0124] The compounds of the present invention have antimalarial activity and are useful as therapeutic and / or preventive agents for malaria. Furthermore, the compounds of the present invention are useful as pharmaceuticals and preferably have one or more of the following excellent characteristics: a) weak inhibitory effect on CYP enzymes (e.g., CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, etc.); b) good pharmacokinetics, such as high bioavailability and moderate clearance; c) high metabolic stability; d) no irreversible inhibitory effect on CYP enzymes (e.g., CYP3A4) within the concentration range of the measurement conditions described herein; e) no mutagenicity; f) low cardiovascular risk; g) high solubility; h) long blood half-life; i) high tissue distribution; j) weak or no inhibitory effect on transporters; k) not a substrate for transporters. l) Binds to the Qi site (quinone binding site) and / or Qo site (quinol binding site) of Complex III of the malaria mitochondrial respiratory chain. m) Has weak or no inhibitory effect on Complex III of the human mitochondrial respiratory chain. n) Does not exhibit reproductive toxicity (e.g., teratogenicity, etc.).

[0125] The pharmaceutical composition containing the compound of the present invention can be administered orally or parenterally. Examples of parenteral administration include transdermal, subcutaneous, intravenous, intraarterial, intramuscular, intraperitoneal, transmucosal, inhalation, nasal, ocular, otic, and vaginal administration.

[0126] For oral administration, the composition may be prepared and administered in any of the commonly used dosage forms, such as solid preparations for internal use (e.g., tablets, powders, granules, capsules, pills, films, etc.) and liquid preparations for internal use (e.g., suspensions, emulsions, elixirs, syrups, lemonades, spirits, perfumes, extracts, decoctions, tinctures, etc.), according to conventional methods. Tablets may be sugar-coated tablets, film-coated tablets, enteric-coated tablets, sustained-release tablets, troches, sublingual tablets, buccal tablets, chewable tablets, or orally disintegrating tablets; powders and granules may be dry syrups; and capsules may be soft capsules, microcapsules, or sustained-release capsules.

[0127] In the case of parenteral administration, the compound can be suitably administered in any of the commonly used dosage forms, such as injections, infusions, and topical preparations (e.g., eye drops, nasal drops, ear drops, aerosols, inhalants, lotions, infusions, liniments, mouthwashes, enemas, ointments, plasters, jellies, creams, patches, poultices, powders for topical use, suppositories, etc.). Injections may be emulsions such as O / W, W / O, O / W / O, and W / O / W types.

[0128] Pharmaceutical compositions can be prepared by mixing an effective amount of the compound of the present invention with various pharmaceutical additives, such as excipients, binders, disintegrants, and lubricants, appropriate for the dosage form, as needed. Furthermore, by appropriately modifying the effective amount of the compound of the present invention, the dosage form, and / or the various pharmaceutical additives, the pharmaceutical composition can also be prepared as a pharmaceutical composition for pediatrics, the elderly, critically ill patients, or surgical patients. For example, pediatric pharmaceutical compositions can be administered to newborns (less than 4 weeks old), infants (4 weeks old to less than 1 year old), toddlers (1 year old to less than 7 years old), children (7 years old to less than 15 years old), or patients aged 15 to 18 years. For example, pharmaceutical compositions for the elderly can be administered to patients aged 65 years or older.

[0129] The dosage of a pharmaceutical composition containing the compound of the present invention is desirably determined taking into consideration the patient's age, body weight, type and severity of the disease, route of administration, etc., but in the case of oral administration, it is usually 0.05 to 100 mg / kg / day, preferably 0.1 to 10 mg / kg / day. In the case of parenteral administration, it varies greatly depending on the route of administration, but is usually 0.005 to 10 mg / kg / day, preferably 0.01 to 1 mg / kg / day. This dosage can be administered once or in divided doses per day.

[0130] The compound of the present invention can be used in combination with other drugs (e.g., antimalarial drugs, etc.; the other drugs may be multiple (hereinafter referred to as concomitant drugs)) for the purpose of enhancing the effect of the compound or reducing the dose of the compound. In this case, the administration timing of the compound of the present invention and the concomitant drug is not limited, and they may be administered to the subject simultaneously or at staggered times. Furthermore, the compound of the present invention and the concomitant drug may be administered as two or more types of preparations containing the respective active ingredients, or as a single preparation containing those active ingredients.

[0131] The dose of the concomitant drug can be appropriately selected based on the clinically used dose. The compounding ratio of the compound of the present invention to the concomitant drug can be appropriately selected depending on the administration subject, administration route, target disease, symptoms, combination, etc. For example, when the administration subject is a human, 0.01 to 100 parts by weight of the concomitant drug may be used per 1 part by weight of the compound of the present invention.

[0132] The present invention will be explained in more detail below with reference to Examples, Reference Exam...

Claims

1. Formula (I): (Wherein, Z is —CR ６ａ R ６ｂ -CR ７ａ R ７ｂ -, -CR ８ａ R ８ｂ -, -CH=CH-, -CH=N-, or -N=CH-; R ６ａ and R ６ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R ７ａ and R ７ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R ８ａ and R ８ｂ are each independently a hydrogen atom, a halogen atom, a cyano group, or a substituted or unsubstituted alkyl group; R １ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ２ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ３ is a hydrogen atom, a halogen atom, a cyano, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted alkyloxy, a substituted or unsubstituted alkenyloxy, or a substituted or unsubstituted alkynyloxy, provided that Z is -CR ８ａ R ８ｂ -, then halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; R ４ is a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, or substituted or unsubstituted alkynyloxy; L １ is a single bond or -CR ９ａ R ９ｂ - and R ９ａ and R ９ｂ are each independently a hydrogen atom, a halogen atom, a cyano, a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group; or ７ａ and R ９ａ may be taken together with the carbon atom to which they are attached to form a substituted or unsubstituted non-aromatic heterocycle; L ２ is a single bond, a substituted or unsubstituted alkylene, or a substituted or unsubstituted non-aromatic carbocyclic diyl; R ５ is a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbocyclic group, a substituted or unsubstituted non-aromatic carbocyclic group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted non-aromatic heterocyclic group), excluding the following compounds: ), or a pharmaceutically acceptable salt thereof.

2. R ４ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy.

3. R ４ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein is a hydrogen atom or a halogen.

4. R ２ The compound according to any one of claims 1 to 3, wherein is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof.

5. R １ The compound according to any one of claims 1 to 4, wherein is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof.

6. R ３ The compound according to any one of claims 1 to 5, wherein is a hydrogen atom, halogen, cyano, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkyloxy, or a pharmaceutically acceptable salt thereof.

7. L １ But, -CR ９ａ R ９ｂ - and L ２ The compound according to any one of claims 1 to 6, wherein is a single bond, or a substituted or unsubstituted alkylene, or a pharmaceutically acceptable salt thereof.

8. L １ But, -CR ９ａ R ９ｂ - and R ９ａ and R ９ｂ is a hydrogen atom; ２ The compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, wherein is a single bond.

9. Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ The compound according to any one of claims 1 to 8, wherein -, -CH=CH-, -CH=N-, or -N=CH-, or a pharmaceutically acceptable salt thereof.

10. Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ The compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof, wherein 11. Z is -CR ６ａ R ６ｂ -CR ７ａ R ７ｂ - and R ６ａ , R ６ｂ , R ７ａ and R ７ｂ The compound according to any one of claims 1 to 8, or a pharmaceutically acceptable salt thereof, wherein is a hydrogen atom.

12. R ５ The compound according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, wherein is a substituted or unsubstituted aromatic carbocyclic group, or a substituted or unsubstituted aromatic heterocyclic group.

13. R ５ The compound according to any one of claims 1 to 11, or a pharmaceutically acceptable salt thereof, wherein is a substituted or unsubstituted aromatic carbocyclic group.

14. The compound of claim 1, or a pharmaceutically acceptable salt thereof, selected from the group consisting of compounds I-045, I-063, I-079, I-085, I-090, I-091, I-098, I-137, I-144, I-147, I-152, I-213, I-215, I-227, I-236, I-241, I-244, I-250, I-255, I-261, I-262, I-263, I-267, I-268, I-270, I-273, I-274, I-275, I-277, I-278, and I-279.

15. A pharmaceutical composition comprising a compound according to any one of claims 1 to 14, or a pharmaceutically acceptable salt thereof.

16. A pharmaceutical composition for preventing and / or treating malaria, comprising a compound according to any one of claims 1 to 14 or a pharmaceutically acceptable salt thereof.

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