Chidamide polymorph i and preparation method therefor
By preparing Chidamide crystal form I, the problems of low stability and bioavailability in the existing technology have been solved, and a more efficient and environmentally friendly pharmaceutical crystal form preparation has been achieved, which is suitable for large-scale production.
WO2026091339A1PCT designated stage Publication Date: 2026-05-07CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
- Filing Date
- 2025-02-26
- Publication Date
- 2026-05-07
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Figure CN2025079154_07052026_PF_FP_ABST
Abstract
The present invention relates to the field of pharmaceutical polymorphs, and specifically relates to a chidamide polymorph I and a preparation method therefor. The chidamide polymorph I has good stability, fluidity, solubility and bioavailability, and low hygroscopicity, has the advantage of being manufactured as a drug, and can be developed as a pharmaceutical polymorph. The preparation method for the polymorph I is simple, has good repeatability and high yield, is easy to operate, is environmentally friendly, requires a small amount of solvent, is beneficial to recycling, can effectively reduce reagent costs, and is easy to realize large-scale production.
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