Anti-PD-1 antibodies and methods of use

Binding molecules targeting PD-1 inhibit its interaction with PD-L1 and PD-L2, addressing the challenge of immune evasion by tumors and enhancing cancer treatment efficacy through immune activation.

WO2026112407A1PCT designated stage Publication Date: 2026-05-28ALMAGRO JUAN CARLOS +1
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Patent Information

Application Number
PCT/US2025/056530
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-07-02
Filing Date
2025-11-21
Publication Date
2026-05-28

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Abstract

Provided herein are binding molecules that bind to programmed cell death protein 1 (PD-1). Such binding molecules block the interaction between PD-1 and programmed death-ligand 1 and 2 (PD-L1 and PD-L2). Also provided herein are methods of using such binding molecules for preventing and treating cancer.
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Citation Information

Patent Citations

  • Combination therapy of t cell activating bispecific antigen binding molecules and PD-1 axis binding antagonists

    US20210087291A1

  • Asgpr antibodies and uses thereof

    WO2014023709A1