Anti-LRRC15 antibodies and uses thereof

Abstract

Provided herein are isolated anti-LRRC15 antibodies, antigen binding portions thereof, bispecific antibodies, and conjugates (e.g., antibody-drug conjugates), which specifically bind to LRRC15 and are internalized by LRRC15 expressing cells. Also provided are nucleic acids encoding the anti-LRRC15 antibodies and antigen binding portions, methods for treating cancer comprising administration of LRRC15-targeted antibodies, antigen binding portions thereof, bispecific antibodies, and conjugates and / or associated therapies, as well as methods of diagnosis, and kits.