Autophagy inducer

Plant-derived ceramides, particularly from konjac potato, offer a safer and more effective solution to induce autophagy, addressing the limitations of existing agents by enhancing autophagy induction and disease prevention.

WO2026116494A1PCT designated stage Publication Date: 2026-06-04DAICEL CORP +1
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
DAICEL CORP
Filing Date
2025-11-28
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

Existing autophagy-inducing agents, such as rapamycin and chloroquine, may not provide safe and effective long-term protection against diseases due to their potential side effects, and there is a need for natural, safe ingredients that can induce autophagy effectively.

Method used

The use of plant-derived ceramides, particularly those derived from konjac potato, as active ingredients in autophagy inducers, which can be formulated into various dosage forms to induce autophagy safely and effectively.

Benefits of technology

Plant-derived ceramides, especially konjac potato-derived ceramides, demonstrate a higher autophagy-inducing effect compared to animal-derived ceramides, providing a safer and more effective means to induce autophagy and prevent or improve neurodegenerative diseases and other conditions associated with autophagy abnormalities.

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Abstract

The purpose of the present disclosure is to provide a novel component that is useful as an active ingredient in an autophagy inducer. A vegetable ceramide according to the present disclosure is useful as an active ingredient in an autophagy inducer.
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