Tattoo composition including graphene oxide for hair loss prevention, moisturization, or Anti-inflammatory effect

Abstract

The present application relates to a tattoo composition including graphene oxide. A tattoo composition according to embodiments of the present application includes graphene oxide, which is harmless to the human body, as a coloring agent, and, compared with conventional tattoo compositions including a pigment, can reduce the occurrence of side effects such as infection, inflammatory reactions, and aggravation of skin diseases during a procedure.

Description

Hair loss prevention, moisturizing, or anti-inflammatory tattoo composition containing graphene oxide

[0001] The present invention relates to a tattoo composition comprising graphene oxide.

[0002] Tattoo refers to the creation of permanent or semi-permanent letters, pictures, or patterns by injecting pigment into the epidermis and / or dermis of mammalian skin using needles or other related devices. The tattoo market is continuously growing, and according to the Korea Tattoo Association, the size of the domestic tattoo and semi-permanent makeup market reached approximately 2 trillion won in 2022.

[0003] Since tattoos may discolor or fade over time, potentially failing to display their original color, the initial color must be maintained as permanently or semi-permanently as possible. Additionally, as the pigment composition penetrates wounds in the skin or subcutaneous tissue during the tattooing process, the pigment composition must be harmless to the human body.

[0004] [Prior Art Literature]

[0005] [Patent Literature]

[0006] Republic of Korea Registered Patent Publication No. 2084261

[0007] The present invention aims to provide a tattoo composition comprising graphene oxide.

[0008] However, the problems that this invention seeks to solve are not limited to those mentioned above, and other unmentioned problems will be clearly understood by a person skilled in the art from the description below.

[0009] One aspect of the present invention provides a tattoo composition comprising graphene oxide, a solvent, and an additive.

[0010] The tattoo composition according to the embodiments of the present invention includes graphene oxide, which is harmless to the human body, as a coloring agent, and compared to conventional tattoo compositions containing pigments, the occurrence of side effects such as infection, inflammatory reaction, and worsening of skin disease during the procedure may be reduced.

[0011] FIG. 1 is a magnified image of a skin tattoo made of graphene oxide in one embodiment of the present invention.

[0012] Figures 2 and 3 are optical microscope images of a skin tattoo made of graphene oxide and a dye of a comparative example in one embodiment of the present invention.

[0013] Figures 4 and 5 are optical microscope images of a skin inflammatory reaction caused by a skin tattoo using graphene oxide and a dye of a comparative example in one embodiment of the present invention.

[0014] Hereinafter, embodiments and examples of the present invention are described in detail with reference to the attached drawings so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments and examples described herein. Furthermore, in order to clearly explain the present invention in the drawings, parts unrelated to the explanation have been omitted, and similar parts throughout the specification have been given similar reference numerals.

[0015] Throughout this specification, when a part is described as being "connected" to another part, this includes not only cases where they are "directly connected," but also cases where they are "electrically connected" with other elements interposed between them.

[0016] Throughout this specification, when a component is described as being located "on" another component, this includes not only cases where a component is in contact with another component, but also cases where another component exists between the two components.

[0017] Throughout this specification, when a part is described as "comprising" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0018] Terms of degree used in this specification, such as “about,” “substantially,” etc., are used to mean at or near the stated value when inherent manufacturing and material tolerances are presented in the stated meaning, and are used to prevent unscrupulous infringers from unfairly exploiting the disclosure in which precise or absolute values ​​are mentioned to aid in understanding the invention.

[0019] The terms “step of” or “step of” as used throughout this specification do not mean “step for”.

[0020] Throughout this specification, the term “combination(s) of these” included in the Markush-type expression means one or more mixtures or combinations selected from the group consisting of the components described in the Markush-type expression, and means including one or more selected from the group consisting of said components.

[0021] Throughout this specification, the description of "A and / or B" means "A or B, or A and B".

[0022] Throughout this specification, the "diameter" of graphene oxide refers to the length of the longest line passing through the center of the graphene oxide particle from one end to the other of the graphene oxide.

[0023] Throughout this specification, the "average diameter" of graphene oxide refers to the average value of the diameter distribution of graphene oxide.

[0024] Throughout this specification, the term "tattoo" means inscribing letters, pictures, or patterns that last permanently or semi-permanently by injecting pigment into the epidermis and / or dermis of mammalian skin using a needle or other related device.

[0025] Embodiments of the present invention have been described in detail below, but the present invention may not be limited thereto.

[0026] The first aspect of the present invention provides a tattoo composition comprising graphene oxide, a solvent, and an additive.

[0027] In one embodiment of the present invention, the graphene oxide may act as a coloring agent.

[0028] In one embodiment of the present invention, the average diameter of the graphene oxide may be about 1 nm or more, about 10 nm or more, about 30 nm or more, about 50 nm or more, about 70 nm or more, about 90 nm or more, about 100 nm or more, about 150 nm or more, about 200 nm or more, about 250 nm or more, about 300 nm or more, about 350 nm or more, about 400 nm or more, about 450 nm or more, about 500 nm or more, about 550 nm or more, about 600 nm or more, about 650 nm or more, about 700 nm or more, about 750 nm or more, about 800 nm or more, about 850 nm or more, about 900 nm or more, about 950 nm or more, about 1,000 nm or more, about 1,100 nm or more, about 1,500 nm or more, or about 2,000 nm or more.

[0029] In one embodiment of the present invention, the average diameter of the graphene oxide may be about 2,000 nm or less, about 1,500 nm or less, about 1,100 nm or less, about 1,000 nm or less, about 950 nm or less, about 900 nm or less, about 850 nm or less, about 800 nm or less, about 750 nm or less, about 700 nm or less, about 650 nm or less, about 600 nm or less, about 550 nm or less, about 500 nm or less, about 450 nm or less, about 400 nm or less, about 350 nm or less, about 300 nm or less, about 250 nm or less, about 200 nm or less, about 150 nm or less, or about 100 nm or less.

[0030] In one embodiment of the present invention, the average diameter of the graphene oxide is about 1 nm to about 2,000 nm, about 1 nm to about 1,500 nm, about 1 nm to about 1,000 nm, about 1 nm to about 950 nm, about 1 nm to about 900 nm, about 1 nm to about 850 nm, about 1 nm to about 800 nm, about 1 nm to about 750 nm, about 1 nm to about 700 nm, about 1 nm to about 650 nm, about 1 nm to about 600 nm, about 1 nm to about 550 nm, about 1 nm to about 500 nm, about 1 nm to about 450 nm, about 1 nm to about 400 nm, about 1 nm to about 350 nm, about 1 nm to about 300 nm, about 1 nm to about 250 nm, about 1 nm to about 200 nm, about 1 nm to about 150 nm, about 1 nm to about 100 nm, about 10 nm to about 2,000 nm, about 10 nm to about 1,500 nm, about 10 nm to about 1,000 nm, about 10 nm to about 950 nm, 10 nm to about 900 nm, about 10 nm to about 850 nm, about 10 nm to about 800 nm, about 10 nm to about 750 nm, about 10 nm to about 700 nm, about 10 nm to about 650 nm, about 10 nm to about 600 nm, about 10 nm to about 550 nm, about 10 nm to about 500 nm, about 10 nm to about 450 nm, about 10 nm to about 400 nm, about 10 nm to about 350 nm, about 10 nm to about 300 nm, about 10 nm to about 250 nm, about 10 nm to about 200 nm, about 10 nm to about 150 nm, about 10 nm to about 100 nm, about 30 nm to about 2,000 nm, about 30 nm to about 1,500 nm, about 30 nm to about 1,000 nm, about 30 nm to about 950 nm,About 30 nm to about 900 nm, about 30 nm to about 850 nm, about 30 nm to about 800 nm, about 30 nm to about 750 nm, about 30 nm to about 700 nm, about 30 nm to about 650 nm, about 30 nm to about 600 nm, about 30 nm to about 550 nm, about 30 nm to about 500 nm, about 30 nm to about 450 nm, about 30 nm to about 400 nm, about 30 nm to about 350 nm, about 30 nm to about 300 nm, about 30 nm to about 250 nm, about 30 nm to about 200 nm, about 30 nm to about 150 nm, about 30 nm to about 100 nm, about 50 nm to about 2,000 nm, about 50 nm to about 1,500 nm, about 50 nm to about 1,000 nm, about 50 nm to about 950 nm, about 50 nm to about 900 nm, about 50 nm to about 850 nm, about 50 nm to about 800 nm, about 50 nm to about 750 nm, about 50 nm to about 700 nm, about 50 nm to about 650 nm, about 50 nm to about 600 nm, about 50 nm to about 550 nm, about 50 nm to about 500 nm, about 50 nm to about 450 nm, about 50 nm to about 400 nm, about 50 nm to about 350 nm, about 50 nm to about 300 nm, about 50 nm to about 250 nm, about 50 nm to about 200 nm, about 50 nm to about 150 nm, about 50 nm to about 100 nm, about 70 nm to about 2,000 nm, about 70 nm to about 1,500 nm, about 70 nm to about 1,000 nm, about 70 nm to about 950 nm, about 70 nm to about 900 nm, about 70 nm to about 850 nm, about 70 nm to about 800 nm, about 70 nm to about 750 nm, about 70 nm to about 700 nm,About 70 nm to about 650 nm, about 70 nm to about 600 nm, about 70 nm to about 550 nm, about 70 nm to about 500 nm, about 70 nm to about 450 nm, about 70 nm to about 400 nm, about 70 nm to about 350 nm, about 70 nm to about 300 nm, about 70 nm to about 250 nm, about 70 nm to about 200 nm, about 70 nm to about 150 nm, about 70 nm to about 100 nm, about 90 nm to about 2,000 nm, about 90 nm to about 1,500 nm, about 90 nm to about 1,000 nm, about 90 nm to about 950 nm, about 90 nm to about 900 nm, about 90 nm to about 850 nm, about 90 nm to Approx. 800 nm, approx. 90 nm to approx. 750 nm, approx. 90 nm to approx. 700 nm, approx. 90 nm to approx. 650 nm, approx. 90 nm to approx. 600 nm, approx. 90 nm to approx. 550 nm, approx. 90 nm to approx. 500 nm, approx. 90 nm to approx. 450 nm, approx. 90 nm to approx. 400 nm, approx. 90 nm to approx. 350 nm, approx. 90 nm to approx. 300 nm, approx. 90 nm to approx. 250 nm, approx. 90 nm to approx. 200 nm, approx. 90 nm to approx. 150 nm, approx. 90 nm to approx. 100 nm, approx. 100 nm to approx. 2,000 nm, approx. 100 nm to approx. 1,500 nm, approx. 100 nm to approx. 1,000 nm, approx. 100 nm to approx. 950 nm, about 100 nm to about 900 nm, about 100 nm to about 850 nm, about 100 nm to about 800 nm, about 100 nm to about 750 nm, about 100 nm to about 700 nm, about 100 nm to about 650 nm, about 100 nm to about 600 nm, about 100 nm to about 550 nm, about 100 nm to about 500 nm,About 100 nm to about 450 nm, about 100 nm to about 400 nm, about 100 nm to about 350 nm, about 100 nm to about 300 nm, about 100 nm to about 250 nm, about 100 nm to about 200 nm, about 100 nm to about 150 nm, about 150 nm to about 2,000 nm, about 150 nm to about 1,500 nm, about 150 nm to about 1,000 nm, about 150 nm to about 950 nm, about 150 nm to about 900 nm, about 150 nm to about 850 nm, about 150 nm to about 800 nm, about 150 nm to about 750 nm, about 150 nm to about 700 nm, about 150 nm to about 650 nm, about 150 nm to about 600 nm, about 150 nm to about 550 nm, about 150 nm to about 500 nm, about 150 nm to about 450 nm, about 150 nm to about 400 nm, about 150 nm to about 350 nm, about 150 nm to about 300 nm, about 150 nm to about 250 nm, about 150 nm to about 200 nm, about 200 nm to about 2,000 nm, about 200 nm to about 1,500 nm, about 200 nm to about 1,000 nm, about 200 nm to about 950 nm, about 200 nm to about 900 nm, about 200 nm to about 850 nm, about 200 nm to about 800 nm, about 200 nm to about 750 nm, about 200 nm to about 700 nm, about 200 nm to about 650 nm, about 200 nm to about 600 nm, about 200 nm to about 550 nm, about 200 nm to about 500 nm, about 200 nm to about 450 nm, about 200 nm to about 400 nm, about 200 nm to about 350 nm, about 200 nm to about 300 nm, about 200 nm to about 250 nm, about 250 nm to about 2,000 nm, approximately 250 nm to approximately 1,500 nm, approximately 250 nm to approximately 1,000 nm, approximately 250 nm to approximately 950 nm, approximately 250 nm to approximately 900 nm, approximately 250 nm to approximately 850 nm, approximately 250 nm to approximately 800 nm, approximately 250 nm to approximately 750 nm, approximately 250 nm to approximately 700 nm, approximately 250 nm to approximately 650 nm, approximately 250 nm to approximately 600 nm, approximately 250 nm to approximately 550 nm, approximately 250 nm to approximately 500 nm, approximately 250 nm to approximately 450 nm, approximately 250 nm to approximately 400 nm, approximately 250 nm to approximately 350 nm, approximately 250 nm to approximately 300 nm, approximately 300 nm to approximately 2,000 nm, about 300 nm to about 1,500 nm, about 300 nm to about 1,000 nm, about 300 nm to about 950 nm, about 300 nm to about 900 nm, about 300 nm to about 850 nm, about 300 nm to about 800 nm, about 300 nm to about 750 nm, about 300 nm to about 700 nm, about 300 nm to about 650 nm, about 300 nm to about 600 nm, about 300 nm to about 550 nm, about 300 nm to about 500 nm, about 300 nm to about 450 nm, about 300 nm to about 400 nm, about 300 nm to about 350 nm, about 350 nm to about 2,000 nm, about 350 nm to about 1,500 nm, about 350 nm to about 1,000 nm, about 350 nm to about 950 nm, about 350 nm to about 900 nm, about 350 nm to about 850 nm, about 350 nm to about 800 nm, about 350 nm to about 750 nm, about 350 nm to about 700 nm, about 350 nm to about 650 nm, about 350 nm to about 600 nm, about 350 nm to about 550 nm,Approximately 350 nm to approximately 500 nm, approximately 350 nm to approximately 450 nm, approximately 350 nm to approximately 400 nm, approximately 400 nm to approximately 2,000 nm, approximately 400 nm to approximately 1,500 nm, approximately 400 nm to approximately 1,000 nm, approximately 400 nm to approximately 950 nm, approximately 400 nm to approximately 900 nm, approximately 400 nm to approximately 850 nm, approximately 400 nm to approximately 800 nm, approximately 400 nm to approximately 750 nm, approximately 400 nm to approximately 700 nm, approximately 400 nm to approximately 650 nm, approximately 400 nm to approximately 600 nm, approximately 400 nm to approximately 550 nm, approximately 400 nm to approximately 500 nm, approximately 400 nm to approximately 450 nm, approximately 450 nm to about 2,000 nm, about 450 nm to about 1,500 nm, about 450 nm to about 1,000 nm, about 450 nm to about 950 nm, about 450 nm to about 900 nm, about 450 nm to about 850 nm, about 450 nm to about 800 nm, about 450 nm to about 750 nm, about 450 nm to about 700 nm, about 450 nm to about 650 nm, about 450 nm to about 600 nm, about 450 nm to about 550 nm, about 450 nm to about 500 nm, about 500 nm to about 2,000 nm, about 500 nm to about 1,500 nm, about 500 nm to about 1,000 nm, about 500 nm to about 950 nm, about 500 nm to about 900 nm, about 500 nm to about 850 nm, about 500 nm to about 800 nm, about 500 nm to about 750 nm, about 500 nm to about 700 nm, about 500 nm to about 650 nm, about 500 nm to about 600 nm, about 500 nm to about 550 nm, about 550 nm to about 2,000 nm, about 550 nm to about 1,500 nm,About 550 nm to about 1,000 nm, about 550 nm to about 950 nm, about 550 nm to about 900 nm, about 550 nm to about 850 nm, about 550 nm to about 800 nm, about 550 nm to about 750 nm, about 550 nm to about 700 nm, about 550 nm to about 650 nm, about 550 nm to about 600 nm, about 600 nm to about 2,000 nm, about 600 nm to about 1,500 nm, about 600 nm to about 1,000 nm, about 600 nm to about 950 nm, about 600 nm to about 900 nm, about 600 nm to about 850 nm, about 600 nm to about 800 nm, about 600 nm to about 750 nm, Approximately 600 nm to approximately 700 nm, approximately 600 nm to approximately 650 nm, approximately 600 nm to approximately 600 nm, approximately 600 nm to approximately 550 nm, approximately 650 nm to approximately 2,000 nm, approximately 650 nm to approximately 1,500 nm, approximately 650 nm to approximately 1,000 nm, approximately 650 nm to approximately 950 nm, approximately 650 nm to approximately 900 nm, approximately 650 nm to approximately 850 nm, approximately 650 nm to approximately 800 nm, approximately 650 nm to approximately 750 nm, approximately 650 nm to approximately 700 nm, approximately 700 nm to approximately 2,000 nm, approximately 700 nm to approximately 1,500 nm, approximately 700 nm to approximately 1,000 nm, approximately 700 nm to approximately 950 nm, about 700 nm to about 900 nm, about 700 nm to about 850 nm, about 700 nm to about 800 nm, about 700 nm to about 750 nm, about 750 nm to about 2,000 nm, about 750 nm to about 1,500 nm, about 750 nm to about 1,000 nm, about 750 nm to about 950 nm, about 750 nm to about 900 nm, about 750 nm to about 850 nm,Approximately 750 nm to approximately 800 nm, approximately 800 nm to approximately 2,000 nm, approximately 800 nm to approximately 1,500 nm, approximately 800 nm to approximately 1,000 nm, approximately 800 nm to approximately 950 nm, approximately 800 nm to approximately 900 nm, approximately 800 nm to approximately 850 nm, approximately 850 nm to approximately 2,000 nm, approximately 850 nm to approximately 1,500 nm, approximately 850 nm to approximately 1,000 nm, approximately 850 nm to approximately 950 nm, approximately 850 nm to approximately 900 nm, approximately 900 nm to approximately 2,000 nm, approximately 900 nm to approximately 1,500 nm, approximately 900 nm to approximately 1,000 nm, approximately 900 nm to approximately 950 nm, approximately It may be 950 nm to about 2,000 nm, about 950 nm to about 1,500 nm, or about 950 nm to about 1,000 nm.

[0031] In one embodiment of the present invention, the average thickness of the graphene oxide may be about 1 nm or more, about 5 nm or more, about 10 nm or more, about 20 nm or more, about 30 nm or more, about 40 nm or more, about 50 nm or more, about 60 nm or more, about 70 nm or more, about 80 nm or more, about 90 nm or more, about 100 nm or more, about 150 nm or more, about 200 nm or more, about 250 nm or more, or about 300 nm or more.

[0032] In one embodiment of the present invention, the average thickness of the graphene oxide may be about 1 nm or less, about 5 nm or less, about 10 nm or less, about 20 nm or less, about 30 nm or less, about 40 nm or less, about 50 nm or less, about 60 nm or less, about 70 nm or less, about 80 nm or less, about 90 nm or less, about 100 nm or less, about 150 nm or less, about 200 nm or less, about 250 nm or less, or about 300 nm or less.

[0033] In one embodiment of the present invention, the average thickness of the graphene oxide is about 1 nm to about 300 nm, about 1 nm to about 250 nm, about 1 nm to about 200 nm, about 1 nm to about 150 nm, about 1 nm to about 100 nm, about 1 nm to about 90 nm, about 1 nm to about 80 nm, about 1 nm to about 70 nm, about 1 nm to about 60 nm, about 1 nm to about 50 nm, about 1 nm to about 40 nm, about 1 nm to about 30 nm, about 1 nm to about 20 nm, about 1 nm to about 10 nm, about 1 nm to about 5 nm, about 5 nm to about 300 nm, about 5 nm to about 250 nm, about 5 nm to about 200 nm, about 5 nm to about 150 nm, about 5 nm to about 100 nm, about 5 nm to about 90 nm, about 5 nm to about 80 nm, about 5 nm to about 70 nm, about 5 nm to about 60 nm, about 5 nm to about 50 nm, about 5 nm to about 40 nm, about 5 nm to about 30 nm, about 5 nm to about 20 nm, about 5 nm to about 10 nm, about 10 nm to about 300 nm, about 10 nm to about 250 nm, about 10 nm to about 200 nm, about 10 nm to about 150 nm, about 10 nm to about 100 nm, about 10 nm to about 90 nm, about 10 nm to about 80 nm, about 10 nm to about 70 nm, about 10 nm to about 60 nm, about 10 nm to about 50 nm, about 10 nm to about 40 nm, about 10 nm to about 30 nm, about 10 nm to about 20 nm, about 30 nm to about 300 nm, about 30 nm to about 250 nm, about 30 nm to about 200 nm, about 30 nm to about 150 nm, about 30 nm to about 100 nm, about 30 nm to about 90 nm,About 30 nm to about 80 nm, about 30 nm to about 70 nm, about 30 nm to about 60 nm, about 30 nm to about 50 nm, about 30 nm to about 40 nm, about 50 nm to about 300 nm, about 50 nm to about 250 nm, about 50 nm to about 200 nm, about 50 nm to about 150 nm, about 50 nm to about 100 nm, about 50 nm to about 90 nm, about 50 nm to about 80 nm, about 50 nm to about 70 nm, about 50 nm to about 60 nm, about 70 nm to about 300 nm, about 70 nm to about 250 nm, about 70 nm to about 200 nm, about 70 nm to about 150 nm, about 70 nm to about 100 nm, about 70 nm to about It may be 90 nm, about 70 nm to about 80 nm, about 90 nm to about 300 nm, about 90 nm to about 250 nm, about 90 nm to about 200 nm, about 90 nm to about 150 nm, about 90 nm to about 100 nm, about 100 nm to about 300 nm, about 100 nm to about 250 nm, about 100 nm to about 200 nm, or about 100 nm to about 150 nm.

[0034] In one embodiment of the present invention, the graphene oxide may be functionalized with one or more functional groups selected from quaternary ammonium salts, alkyl groups, alkoxy groups, hydroxyl groups, carboxyl groups, carbonyl groups, amine groups, nitrile groups, thiol groups, sulfonate groups, aldehyde groups, peroxide groups, ether groups, epoxy groups, and ketone groups.

[0035] In one embodiment of the present invention, the graphene oxide may be functionalized with a quaternary ammonium salt represented by the following chemical formula 1:

[0036] [Chemical Formula 1]

[0037] ;

[0038] In Chemical Formula 1,

[0039] R 1 and R 2 are, respectively, unsubstituted or substituted, linear or branched C 1-10 Alkyl groups, linear or branched C 2-10 alkenyl group, linear or branched C 2-10 alkynyl group, or C 5-10 It is a cycloalkyl group, and

[0040] X - is a halide ion, and

[0041] n is an integer between 10,000 and 10,000,000.

[0042] In one embodiment of the present invention, n is about 10,000 to about 10,000,000, about 10,000 to about 9,000,000, about 10,000 to about 8,000,000, about 10,000 to about 7,000,000, about 10,000 to about 6,000,000, about 10,000 to about 5,000,000, about 10,000 to about 4,000,000, about 10,000 to about 3,000,000, about 10,000 to about 2,000,000, about 10,000 to about 1,000,000, about 10,000 to about 900,000, about It may be an integer ranging from 10,000 to about 800,000, from about 10,000 to about 700,000, from about 10,000 to about 600,000, from about 10,000 to about 500,000, from about 10,000 to about 400,000, from about 10,000 to about 300,000, from about 10,000 to about 200,000, or from about 10,000 to about 100,000.

[0043] In one embodiment of the present invention, R 1 and R 2 In the case of this substitution, R 1 and R 2is a halogen group, hydroxyl group, amino group, carboxyl group, cyano group, nitro group, formyl group, and C 1-10 It may be substituted with one or more selected from alkyl groups.

[0044] In one embodiment of the present invention, X - It can be a fluoride ion, chloride ion, bromide ion, or iodide ion.

[0045] In one embodiment of the present invention, the quaternary ammonium salt may be selected from poly(diallyldimethylammonium) (PDDA) salt, poly(diallyldiethylammonium) salt, poly(diallyldipropylammonium) salt, poly(diallyldibutylammonium) salt, poly(diallyldipentylammonium) salt, and poly(diallyldihexylammonium) salt.

[0046] In one embodiment of the present invention, the graphene oxide may be functionalized with one or more compounds selected from PEG (polyethylene glycol), PSS (poly(styrene sulfonate)), PEI (polyetherimide), PEI (polyethylenimine), PAA (poly(allyl amine)), PNIPAM (poly(N-isopropyl acrylamide), CS (Chitosan), PMA (poly(methacrylic acid)), PVS (poly(vinyl sulfate)), PAA (poly(amic acid)), PAH (poly(allylamine hydrochloride)), PVAc (polyvinyl acetate), PVP (polyvinylpyrrolidone), PVA (polyvinyl alcohol), PMMA (poly(methyl methacrylate)), PC (polycarbonate), and PMIA (Poly(m-phenylene isophthalamide)).

[0047] In one embodiment of the present invention, the concentration of the graphene oxide may be about 0.0001 wt% to about 50 wt%, but is not limited thereto.

[0048] In one embodiment of the present invention, the concentration of graphene oxide is about 0.0001 wt% or more, about 0.001 wt% or more, about 0.01 wt% or more, about 0.1 wt% or more, about 1 wt% or more, about 2 wt% or more, about 3 wt% or more, about 4 wt% or more, about 5 wt% or more, about 6 wt% or more, about 7 wt% or more, about 8 wt% or more, about 9 wt% or more, about 10 wt% or more, about 11 wt% or more, about 12 wt% or more, about 13 wt% or more, about 14 wt% or more, about 15 wt% or more, about 16 wt% or more, about 17 wt% or more, about 18 wt% or more, about 19 wt% or more, about 20 wt% or more, about 21 wt% or more, about 22 wt% or more, approximately 23 wt% or more, approximately 24 wt% or more, approximately 25 wt% or more, approximately 26 wt% or more, approximately 27 wt% or more, approximately 28 wt% or more, approximately 29 wt% or more, approximately 30 wt% or more, approximately 31 wt% or more, approximately 32 wt% or more, approximately 33 wt% or more, approximately 34 wt% or more, approximately 35 wt% or more, approximately 36 wt% or more, approximately 37 wt% or more, approximately 38 wt% or more, approximately 39 wt% or more, approximately 40 wt% or more, approximately 41 wt% or more, approximately 42 wt% or more, approximately 43 wt% or more, approximately 44 wt% or more, approximately 45 wt% or more, approximately 46 wt% or more, approximately 47 wt% or more, approximately 48 wt% or more, approximately 49 wt% It may be more than, or about 50 wt% or more.

[0049] In one embodiment of the present invention, the concentration of graphene oxide is about 1 wt% or less, about 2 wt% or less, about 3 wt% or less, about 4 wt% or less, about 5 wt% or less, about 6 wt% or less, about 7 wt% or less, about 8 wt% or less, about 9 wt% or less, about 10 wt% or less, about 11 wt% or less, about 12 wt% or less, about 13 wt% or less, about 14 wt% or less, about 15 wt% or less, about 16 wt% or less, about 17 wt% or less, about 18 wt% or less, about 19 wt% or less, about 20 wt% or less, about 21 wt% or less, about 22 wt% or less, about 23 wt% or less, about 24 wt% or less, about 25 wt% or less, about 26 wt% or less, about 27 It may be wt% or less, about 28 wt% or less, about 29 wt% or less, about 30 wt% or less, about 31 wt% or less, about 32 wt% or less, about 33 wt% or less, about 34 wt% or less, about 35 wt% or less, about 36 wt% or less, about 37 wt% or less, about 38 wt% or less, about 39 wt% or less, about 40 wt% or less, about 41 wt% or less, about 42 wt% or less, about 43 wt% or less, about 44 wt% or less, about 45 wt% or less, about 46 wt% or less, about 47 wt% or less, about 48 wt% or less, about 49 wt% or less, or about 50 wt% or less.

[0050] In one embodiment of the present invention, the solvent may be a material capable of dissolving the graphene oxide and the additive to form a uniform solution of the tattoo composition, and may not cause a chemical reaction with the graphene oxide and the additive.

[0051] In one embodiment of the present invention, the solvent may include water and / or alcohol, but may not be limited thereto.

[0052] In one embodiment of the present invention, the alcohol may include, but is not limited to, methanol, ethanol, and / or isopropyl alcohol.

[0053] In one embodiment of the present invention, the solvent may be present in an amount of about 10 wt% to about 99.999 wt% of the tattoo composition, but may not be limited thereto.

[0054] In one embodiment of the present invention, the additive may comprise one or more selected from a surfactant, a matrix, a skin penetration enhancer, a preservative, and an emollient, but is not limited thereto.

[0055] In one embodiment of the present invention, the surface activator can serve to reduce the surface tension of the composition.

[0056] In one embodiment of the present invention, the surfactant may comprise, but is not limited to, one or more selected from alkylbenzene sulfonate, polyethylene glycol, alkyl sulfate, alkyl ether sulfate, soap, ethoxylate, lignosulfonate, triglyceride, sodium dodecyl benzenesulfonate, lauryl sulfate, dialkyl sulfosuccinate, tetradecyl phosphonic dimethyl ether, lauryl monoethanol, glycerol diester (diglyceride), dodecyl betaine, abietic acid, polyethoxylated octyl phenol, 1,2-hexanediol, and sorbitan monoester.

[0057] In one embodiment of the present invention, the matrix may comprise a sugar, a sugar alcohol (e.g., sorbitol, mannitol, xylitol, isomalt, hydrogenated starch hydrolysate), a polymer, or a combination thereof.

[0058] For example, the sugar may include monosaccharides (e.g., glucose, fructose, galactose, ribose, and xylose), disaccharides (e.g., trehalose, e.g., TREHALOSE 100, sucrose, lactotrehalose, galactotrehalose, 6-azidotrehalose, maltose, lactose, lactulose, cellobiose, and chitobiose), or oligosaccharides (e.g., starch, glycogen, cellulose, and chitin).

[0059] For example, the polymer may include pullulan, cellulose derivatives (e.g., hydroxypropylmethylcellulose, hydroxyethylcellulose and hydroxymethylcellulose), acrylates, polyvinyl alcohol, ethylene oxide / propylene oxide copolymers, and polyesters.

[0060] In one embodiment of the present invention, the skin penetration enhancer comprises ethanol, isopropanol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyl dodecanol, oleyl alcohol, azone, ethyl acetate, octyl salicylate, Padimate O, ethyl oleate, glyceryl monooleate, glyceryl monocaprate, glyceryl tricaprylate, isopropyl myristate, isopropyl palmitate, propylene glycol monolaurate, propylene glycol monocaprylate, diethylene glycol monoethyl ether (TRANSCUTOL®), lauric acid, linoleic acid, linolenic acid, myristic acid, oleic acid, palmitic acid, stearic acid, isostearic acid, dipropylene glycol, propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, It may comprise, but is not limited to, one or more selected from n-methyl-2-pyrrolidone, 2-pyrrolidone, decylmethyl sulfoxide, dimethyl sulfoxide, sodium lauryl sulfate, alkyl dimethylbenzyl ammonium halide, alkyl trimethyl ammonium halide, alkyl pyridinium halide, brij 36t, polyethylene glycol sorbitan monooleate (e.g., TWEEN 80), eugenol, D-limonene, menthol, menthone, farnesol, and neridol.

[0061] In one embodiment of the present invention, the preservative is ascorbic acid, ascorbate, palmitate, citric acid, benzoate, benzoic acid, propionate, propionic acid, sorbate, sorbic acid, salicylic acid, salicylate, hexa-2,4-dienoic acid, hexa-2,4-dienoate, formaldehyde, formaldehyde release agent, formic acid and its salt, 3-acetyl-6-methylpyran-2,4-(3H)-dione and its salt, 3,3'-dibromo-4,4'-hexamethylenedioxydibenzamidine and its salt, thiomesal, phenyl dimercury salt, undec-10-enic acid and its salt, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-5-pyrimidine, 5-Bromo-5-nitro-1,3-dioxane, bronopol, 2,4-dichlorobenzyl alcohol, 1-(4-chlorophenyl)-3-(3,4-dichlorophenyl) urea, chlorocresol, chloroxylenol, 5-chloro-2-(2,4-dichlorophenoxy) phenol, N,N″-methylenebis[N′-[3-(hydroxymethyl)-2,5-dioxomidazolidin-4-yl]urea], polyaminopropyl biguanide, methenamine, quaternium-15, climbazole, DMDM ​​hydantoin, benzyl alcohol, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone, pyrochton olamin, bromochlorophene, o-cymen-5-ol, chlorophene, chloroacetamide, Methylchloroisothiazolinone, Methylisothiazolinone, Phenoxyisopropanol, Chlorhexidine, Chlorhexidine diacetate, Chlorhexidine digluconate, Chlorhexidine dihydrochloride, Dimethyl oxazolidine, Behentrimonium chloride, Cetrimonium bromide, Cetrimonium chloride, Lautrymonium bromide, Lautrymonium chloride, Steartrymonium bromide, Steartrymonium chloride, Diazolidinyl urea, Hexamidine, Hexamidine diisedianate, Hexamidine paraben, Glutaral, 7-Ethylbicyclooxazolidine, Chlorphenesin, Sodium hydroxymethylglycinate, Silver chloride, Benzethonium chloride, Benzalkonium chloride, Benzalkonium bromide, Benzalkonium saccharinate, Benzyl hemiformal, iodopropynyl butyl carbamate,It may comprise, but is not limited to, one or more selected from biphenyl-2-ol and salts thereof, zinc pyrithioneine, erythorbate, nitrite, ethylenediaminetetraacetic acid (EDTA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), caprylic acid, dilauryl thiodipropionate, erythorbic acid, guaiaque gum, methylparaben, sulfite, bisulfite, metabisulfite, propyl gallate, propylparaben, stannous chloride, sulfur dioxide, thiodipropionic acid, isothiazoline, paraben, phenoxyethanol, ethylhexylglycerin, glycol, and tocopherol.

[0062] In one embodiment of the present invention, the softening agent may comprise one or more selected from alkyl alcohols, glycol alkyl ethers, short-chain hydrocarbons, alkyl esters, collagen, colloidal oatmeal, elastin, glyceryl stearate, isopropyl palmitate, shea butter, and stearic acid, but may not be limited thereto.

[0063] In one embodiment of the present invention, the concentrations of the surfactant, the matrix, the skin penetration enhancer, the preservative, and the emollient may each be about 0.1 wt% to about 10 wt%, but are not limited thereto.

[0064] In one embodiment of the present invention, the concentrations of the surfactant, the matrix, the skin penetration enhancer, the preservative, and the emollient may each be about 0.1 wt% or more, about 0.3 wt% or more, about 0.5 wt% or more, about 1 wt% or more, about 2 wt% or more, about 3 wt% or more, about 4 wt% or more, about 5 wt% or more, about 6 wt% or more, about 7 wt% or more, about 8 wt% or more, about 9 wt% or more, or about 10 wt% or more.

[0065] In one embodiment of the present invention, the concentrations of the surfactant, the matrix, the skin penetration enhancer, the preservative, and the emollient may each be about 0.1 wt% or less, about 0.3 wt% or less, about 0.5 wt% or less, about 1 wt% or less, about 2 wt% or less, about 3 wt% or less, about 4 wt% or less, about 5 wt% or less, about 6 wt% or less, about 7 wt% or less, about 8 wt% or less, about 9 wt% or less, or about 10 wt% or less.

[0066] In one embodiment of the present invention, the tattoo composition may further comprise, but is not limited to, glycerin fatty acid ester as an emulsifier; sodium MA / diisobutylene copolymer, acrylates copolymer, or styrene / acrylates copolymer as a dispersant; sorbic acid, salicylic acid, hexylene glycol, 1,3-butanediol, decane-1,2-diol, or ethyl hexyl glycerin, or totarol as a preservative.

[0067] In one embodiment of the present invention, the tattoo composition may be for scalp tattoos and / or skin tattoos, but may not be limited thereto.

[0068] In one embodiment of the present invention, when the tattoo composition is used on the scalp, it may have excellent growth or proliferation of human hair papilla cells, excellent expression or activity of hair loss improvement factor proteins in human hair papilla cells, and excellent expression or activity of Wnt / β-catenin, and excellent reduction in the expression of hair loss-inducing genes, thereby having an excellent effect in preventing or improving hair loss.

[0069] In one embodiment of the present invention, the tattoo composition may promote the growth or proliferation of human follicle dermal papilla cells (PromoCell).

[0070] In one embodiment of the present invention, the tattoo composition may enhance the expression or activity of a hair loss improvement factor protein in human hair papilla cells.

[0071] In one embodiment of the present invention, the tattoo composition may enhance the expression or activity of one or more selected from VEGF (vascular endothelial growth factor), FGF7 (fibroblast growth factor 7), HGF (hepatocyte growth factor), IGF-1 (insulin-like growth factor-1), and Wnt / β-catenin, but may not be limited thereto.

[0072] In one embodiment of the present invention, the tattoo composition may enhance the expression or activity of Wnt / β-catenin (Wnt / β-catenin activation) in human hair papilla cells.

[0073] In one embodiment of the present invention, the tattoo composition may reduce the expression of a hair loss-inducing gene in human hair papilla cells.

[0074] In one embodiment of the present invention, the tattoo composition may reduce the expression of inflammation-related factors in human hair papilla cells.

[0075] In one embodiment of the present invention, the tattoo composition may reduce the expression of one or more selected from AR (androgen receptor), IL-6 (interleukin-6), TNF-α (Tumor necrosis factor-α), 5αR1 (5α-reductase type 1), 5αR2 (5α-reductase type 2), and DKK-1 (Dickkopf-1), but may not be limited thereto.

[0076] In one embodiment of the present invention, the tattoo composition may increase the expression of a moisturizing factor.

[0077] In one embodiment of the present invention, the tattoo composition may increase HAS2 (hyaluronan synthase 2) gene expression.

[0078] The present invention will be explained in more detail below using examples, but the following examples are merely illustrative to aid in understanding the present invention, and the content of the present invention is not limited to the following examples.

[0079] [Example]

[0080] Example 1: Preparation of a composition containing nanoscale graphene oxide (GO)

[0081] 1) Preparation of graphene oxide with various diameters

[0082] Graphene oxide was prepared using Hummer's method. Graphite was thoroughly stirred in an H2SO4 solution at room temperature, and then KMnO4 was added to the solution. Subsequently, additional H2O2 was added to the solution to induce an oxidation reaction of the graphite and form graphene oxide. Graphene oxide was obtained after undergoing several purification processes. Next, the graphene oxide was dispersed in water to obtain an aqueous dispersion of graphene oxide. Graphene oxide classified into various diameter sizes is used for laser diffraction (Mie scattering method). In the Mie scattering method, scattering (diffraction) occurs when light collides with a particle, and the detector can obtain different electrical signals depending on the angle and intensity of the scattered light. At this time, based on Mie theory, the size distribution of the sample (test product) can be obtained from each different electrical signal. From this, the size (average diameter) of each sample was adjusted. The average diameter of the sample used in the test is 150 nm.

[0083] Experimental Example: Evaluation of Tattoo Retention and Safety of Graphene Oxide in In vivo Porcine Skin

[0084] 1. Evaluation Method

[0085] After anesthetizing the pigs, they were laid in an anatomical position with their abdomen facing upward, and tattooing was performed on their hind legs. Tattoos were applied to the pig skin using samples at different concentrations and under specific conditions. Changes in the surface condition at each time point (day 0, day 1, day 7, day 14, and day 30) were photographed using a dermatoscope (Folliscope® PS, Lead M, Korea). Additionally, to evaluate skin irritation caused by the tattoos, skin tissues were collected at each time point (day 0, day 1, day 7, day 14, and day 30), fixed in 10% formalin, and paraffin blocks were prepared. The retention capacity within the skin was analyzed via H&E staining, and inflammatory factors (mast cells) within the skin were observed using a light microscope (Zeiss Axio 5, Germany) via toluidine blue staining. In addition, RT-qPCR was performed on a 30-day sample of skin tissue to evaluate hair loss and inflammatory factor expression. The tattoo device used was the DIAMANTS vibrating massager from Sungyoon Tech Co., Ltd.

[0086] 2. Test Conditions

[0087] Samples were prepared and evaluated according to Table 1 below. As examples, 1% to 5% graphene oxide was used, and as comparative examples, commercially available products Be&ME Espresso 9780 and Lash Monster Training Multi Pigment were used.

[0088] Untreated group - Graphene oxide 1% Graphene oxide 2% Graphene oxide 4% Graphene oxide 5% Comparative Example 1 Be&ME Espresso 9780 Comparative Example 2 Lash Monster Training Multi Pigment

[0089] 3. Results

[0090] 1) Visual evaluation of graphene oxide skin tattoos

[0091] When observing a skin tattoo made of graphene oxide on pig skin with a skin magnifying glass, it was confirmed that the tattoo was well maintained from immediately after the tattoo until 30 days later (see Fig. 1).

[0092] 2) Evaluation of skin tattoo retention for graphene oxide

[0093] Changes in skin tattoo retention caused by graphene oxide were observed in pig skin via H&E staining using an optical microscope, and the results showed that the tattoos were maintained up to the 30-day mark in all test groups. When analyzing the intensity of the tattoo dye per equal cross-sectional area of ​​skin tissue at the 30-day mark, Be&ME Espresso 9780 and Lash Monster Training Multi Pigment decreased by 85.66% and 94.03%, respectively, compared to the 0-day mark, whereas graphene oxide 1% and 2% decreased by 23.24% and 16.21%, respectively, compared to the 0-day mark, confirming that the tattoos were maintained for a longer period (see Table 2, Figure 2, and Figure 3).

[0094]

[0095] 3) Safety evaluation of graphene oxide for skin tattoos

[0096] As a result of observing the skin inflammatory response caused by graphene oxide in porcine skin tissue through toluidine blue staining, it was confirmed that mast cells increased in the graphene oxide tattoo area at 1 day, and improved with a decrease in mast cells compared to 1 day at 30 days (Figs. 4 and 5).

[0097] 4) Evaluation of the efficacy of graphene oxide in improving inflammation and moisturization-related factors

[0098] As a result of evaluating the expression levels of AR mRNA, an inflammation (hair loss) related factor induced by graphene oxide, in porcine skin tissue at 30 days, AR mRNA expression levels showed a decreasing trend of 25.43% and 17.53% at 1% and 2% graphene oxide, respectively, compared to Be&ME Espresso 9780, and a decreasing trend of 45.54%, 39.78%, and 7.93% at 1%, 2%, and 4% graphene oxide, respectively, compared to Lash Monster Training Multi Pigment (see Table 3).

[0099] Group AR mRNA Expression (Fold) Rate of Change (%, vs. Untreated Group) Rate of Change (%, vs. Be&ME Espresso 9780) Rate of Change (%, vs. Lash Monster Training Multi Pigment) Mean Standard Deviation Standard Error Untreated Group 1.00 0.36 70.259 --- Be&ME Espresso 9780 1.55 0.20 20.14 35 5.27 △ -- Lash Monster Training Multi Pigment 2.13 0.26 40.18 61 12.63 △ 36.94 △ - Graphene Oxide 1% 1.16 0.08 10.05 715.79 △ 25.43 ▼ 45.54 ▼ Graphene Oxide 2% 1.28 0.53 40.37 728.05 △ 17.53 ▼ 39.78 ▼ Graphene Oxide 4%1.96 0.41 00.29 09 5.77△26.09△7.93▼Graphene Oxide 5%2.42 0.12 90.0911 41.93△5 5.81△13.78△

[0100] As a result of evaluating the expression levels of IL-6 mRNA, an inflammation (hair loss) related factor induced by graphene oxide, in porcine skin tissue at 30 days, IL-6 mRNA expression levels showed a decreasing trend of 38.90% at 1% graphene oxide compared to the untreated group, and decreased by 69.16%, 48.80%, 47.83%, and 37.14% at 1%, 2%, 4%, and 5% graphene oxide compared to Be&ME Espresso 9780, respectively, and decreased by 52.08%, 20.43%, 18.93%, and 2.31% at 1%, 2%, 4%, and 5% graphene oxide compared to Lash Monster Training Multi Pigment, respectively (see Table 4).

[0101] Group IL-6 mRNA Expression (Fold) Change Rate (%, vs. Untreated Group) Change Rate (%, vs. Be&ME Espresso 9780) Change Rate (%, vs. Lash Monster Training Multi Pigment) Mean Standard Deviation Standard Error Untreated Group 1.00 0.05 40.038 --- Be&ME Espresso 9780 1.98 0.238 0.168 98.12△ -- Lash Monster Training Multi Pigment 1.27 0.19 0.135 27.49△35.65▼ - Graphene Oxide 1% 0.61 0.145 0.102 38.90▼69.16▼52.08▼ Graphene Oxide 2% 1.01 0.02 0.014 1.45△48.80▼20.43▼ Graphene Oxide 4%1.030.2930.2073.36△47.83▼18.93▼Graphene Oxide 5%1.250.1770.12524.54△37.14▼2.31▼

[0102] As a result of evaluating the expression levels of TNF-α mRNA, an inflammation (hair loss) related factor induced by graphene oxide, in porcine skin tissue at 30 days, TNF-α mRNA expression levels showed a tendency to decrease (improve) from 4% to 8.04% with graphene oxide compared to Be&ME Espresso 9780 (see Table 5).

[0103] Group TNF-α mRNA Expression (Fold) Change Rate (%, vs. Untreated Group) Change Rate (%, vs. Be&ME Espresso 9780) Change Rate (%, vs. Lash Monster Training Multi Pigment) Mean Standard Deviation Standard Error Untreated Group 1.00 0.86 50.611 --- Be&ME Espresso 9780 1.31 1.17 20.82 930.53△ -- Lash Monster Training Multi Pigment 1.01 0.10 70.07 50.59△ 22.94▼ - Graphene Oxide 1% 1.53 0.49 60.35 52.84△ 17.09△ 51.95△ Graphene Oxide 2% 1.99 0.63 60.44 99 9.08△ 52.52△ 97.92△ Graphene Oxide 4%1.200.4650.32820.04△8.04▼19.34△Graphene Oxide 5%1.640.2910.20663.87△25.54△62.91△

[0104] As a result of evaluating the expression levels of the moisturizing factor HAS2 mRNA in porcine skin tissues induced by graphene oxide at 30 days, HAS2 mRNA expression levels showed a trend of increasing (improving) by 30.72%, 17.54%, and 7.15% at 1%, 2%, and 5% graphene oxide compared to the untreated group; compared to Be&ME Espresso 9780, HAS2 mRNA expression levels showed a trend of increasing (improving) by 75.72%, 58.01%, 32.39%, and 44.03% at 1%, 2%, 4%, and 5% graphene oxide, respectively; and compared to Lash Monster Training Multi Pigment, HAS2 mRNA expression levels showed a trend of increasing (improving) by 50.83%, 35.63%, 13.63%, and 23.63% at 1%, 2%, 4%, and 5% graphene oxide, respectively (see Table 6).

[0105] Group HAS2 mRNA Expression (Fold) Change Rate (%, vs. Untreated Group) Change Rate (%, vs. Be&ME Espresso 9780) Change Rate (%, vs. Lash Monster Training Multi Pigment) Mean Standard Deviation Standard Error Untreated Group 1.00 0.00 60.00 4---Be&ME Espresso 978 0.74 0.09 70.06 925.61▽--Lash Monster Training Multi Pigment 0.87 0.01 30.00 91 3.34▽16.50▲- Graphene Oxide 1% 1.31 0.14 60.10 330.72▲75.72▲50.83▲ Graphene Oxide 2% 1.18 0.16 50.116 17.54▲58.01▲35.63▲ Graphene Oxide 4%0.98 0.21 10.15 01.52▽3 2.39▲13.63▲ Graphene Oxide 5%1.07 0.02 30.01 77.15▲44.03▲23.63▲

[0106] The foregoing description of the present invention is for illustrative purposes only, and those skilled in the art will understand that other specific forms can be easily modified without altering the technical concept or essential features of the present invention. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive. For example, each component described as a single unit may be implemented in a distributed manner, and components described as distributed may likewise be implemented in a combined form.

[0107] The scope of the present invention is defined by the claims set forth below rather than by the detailed description above, and all modifications or variations derived from the meaning and scope of the claims and the concept of equivalents thereof should be interpreted as being included within the scope of the present invention.

Claims

1. A tattoo composition comprising graphene oxide, a solvent, and an additive.

2. In Paragraph 1, A tattoo composition having an average diameter of 1 nm to 2,000 nm of the graphene oxide.

3. In Paragraph 1, A tattoo composition having an average diameter of 100 nm to 1,000 nm of the graphene oxide.

4. In Paragraph 1, A tattoo composition having an average thickness of 1 nm to 300 nm of the graphene oxide.

5. In Paragraph 1, A tattoo composition wherein the graphene oxide is functionalized with one or more functional groups selected from quaternary ammonium salts, alkyl groups, alkoxy groups, hydroxyl groups, carboxyl groups, carbonyl groups, amine groups, nitrile groups, thiol groups, sulfonate groups, aldehyde groups, peroxide groups, ether groups, epoxy groups, and ketone groups.

6. In Paragraph 1, A tattoo composition wherein the graphene oxide is functionalized with one or more compounds selected from PEG (polyethylene glycol), PSS (poly(styrene sulfonate)), PEI (polyetherimide), PEI (polyethylenimine), PAA (poly(allyl amine)), PNIPAM (poly(N-isopropyl acrylamide), CS (Chitosan), PMA (poly(methacrylic acid)), PVS (poly(vinyl sulfate)), PAA (poly(amic acid)), PAH (poly(allylamine hydrochloride)), PVAc (polyvinyl acetate), PVP (polyvinylpyrrolidone), PVA (polyvinyl alcohol), PMMA (poly(methyl methacrylate)), PC (polycarbonate), and PMIA (Poly(m-phenylene isophthalamide)).

7. In Paragraph 1, Tattoo composition in which the graphene oxide is functionalized with a quaternary ammonium salt represented by the following chemical formula 1: [Chemical Formula 1] ; In Chemical Formula 1, R 1 and R 2 are, respectively, unsubstituted or substituted, linear or branched C 1-10 Alkyl groups, linear or branched C 2-10 alkenyl group, linear or branched C 2-10 alkynyl group, or C 5-10 It is a cycloalkyl group, and X - is a halide ion, and n is an integer between 10,000 and 10,000,000.

8. In Paragraph 5, A tattoo composition wherein the above-mentioned quaternary ammonium salt is selected from poly(diallyldimethylammonium) (PDDA) salt, poly(diallyldiethylammonium) salt, poly(diallyldipropylammonium) salt, poly(diallyldibutylammonium) salt, poly(diallyldipentylammonium) salt, and poly(diallyldihexylammonium) salt.

9. In Paragraph 1, A tattoo composition wherein the concentration of the graphene oxide is 0.0001 wt% to 50 wt%.

10. In Paragraph 1, A tattoo composition comprising one or more additives selected from a surfactant, a matrix, a skin penetration enhancer, a preservative, and an emollient.

11. In Paragraph 1, The above tattoo composition is a tattoo composition intended for scalp tattooing.

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