Personal care compositions

Abstract

Disclosed herein is a personal care composition for delivering an active ingredient into the skin, the personal care composition comprising at least one cross-linked hyaluronic acid and at least one hydrophilic active ingredient. Also disclosed herein are methods of delivering at least one active ingredient to the skin of a subject comprising applying the personal care composition disclosed herein to the skin.

Description

PERSONAL CARE COMPOSITIONSCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of priority from U.S. Provisional Patent Application No. 63 / 727,291, filed 3 December 2024, the contents of which are hereby incorporated herein by reference in their entirety.BACKGROUND

[0002] Skin is composed of three superposed layers that are, from surface to body depth, epidermis, dermis and hypodermis. The epidermis can be divided, according to morphological and histological criteria, into four layers, from the deepest to the outermost: the basal lamina and the spinosal layer (which form the deep epidermis), the granular layer (superficial epidermis), and the corneal layer (or stratum comeum). The epidermis is in contact with the external environment. One of the roles of the epidermis is to protect the organism from dehydration, as well as chemical, mechanical, and biological exterior aggressions.

[0003] Although personal care compositions, e.g., lotions and creams, are commonly used to deliver active ingredients to the skin, the effect may be transient or ineffective as the active ingredient may not be able to permeate various layers of the skin or maintain contact with the skin. In many cases, the penetration of any active ingredient into the skin can be boosted with chemical additives like dimethyl isosorbide (DMI), which may be used as a penetration enhancer. However, penetration enhancers are essentially a monofunctional ingredient. Aside from their benefits as a penetration enhancer, they have little other skin benefits, adding cost and complexity to the formulation of personal care compositions.

[0004] Accordingly, there is an ongoing desire for personal care compositions that can effectively deliver active ingredients into the skin to provide various benefits.BRIEF SUMMARY

[0005] Aspects of the present disclosure relate to personal care compositions for improving the health of keratin and, particularly, for improving the health and appearance of skin, e.g., moisturizing skin. In accordance with an aspect of the disclosure, provided is a personal care composition for delivering at least one hydrophilic active ingredient into skin, the personal carecomposition comprising at least one cross-linked hyaluronic acid and at least one hydrophilic active ingredient.

[0006] In certain embodiments, the at least one cross-linked hyaluronic acid is present in the personal care composition in an amount ranging from about 0.001 wt.% to about 0.5 wt.%, by weight based on a total weight of the personal care composition.

[0007] In certain embodiments, the at least one hydrophilic active ingredient is selected from amino acids, peptides, vitamins, humectants, and linear hyaluronic acids. In certain embodiments, the at least one hydrophilic active ingredient is an amino acid (e.g., arginine). In certain embodiments, the at least one hydrophilic active ingredient is a peptide (e.g., carnosine). In certain embodiments, the at least one hydrophilic active ingredient is sodium pyroglutamate (PCA). In certain embodiments, the at least one hydrophilic active ingredient is selected from medium molecular weight linear hyaluronic acid (e.g., a medium molecular weight linear hyaluronic acid having a molecular weight of greater than 50,000 to 400,000 Da) and low molecular weight linear hyaluronic acid (e.g., a low molecular weight linear hyaluronic acid having a molecular weight of up to 50,000 Da), optionally medium molecular weight linear hyaluronic acid. In still other embodiments, the at least one active ingredient consists of a medium molecular weight linear hyaluronic acid or low molecular weight linear hyaluronic acid, preferably a medium molecular weight linear hyaluronic acid.

[0008] According to certain aspects disclosed herein, the personal care composition further comprises at least one additional active ingredient, optionally a hydrophobic active ingredient.

[0009] In certain aspects, the at least one hydrophilic active ingredient is present in the personal care composition in an amount ranging from about 0.01 wt.% to about 5 wt.%, such as from about 0.01 wt.% to about 0.5 wt.% or from about 1 wt.% to about 3 wt.%, by weight based on a total weight of the personal care composition.

[0010] In certain embodiments, the at least one cross-linked hyaluronic acid is an elastomer. In certain embodiments, the at least one cross-linked hyaluronic acid is present in an amount ranging from about 0.001 wt.% to about 1 wt.%, such as from about 0.01 wt.% to about 0.5 wt.% or from about 0.01 wt.% to about 0.15 wt.%, by weight based on a total weight of the personal care composition.

[0011] According to certain aspects disclosed herein, the personal care composition is for topical use suitable for application to skin. In certain embodiments, the personal care composition is a leave-on skin care composition, optionally a cream, lotion, or serum.

[0012] Also disclosed herein is a method of delivering at least one active ingredient into skin of a subject, the method comprising applying an effective amount of the personal care composition disclosed herein to the skin of the subject. In certain embodiments, the method enhances delivery of the at least one active ingredient as compared to a personal care composition that does not comprise at least one cross-linked hyaluronic acid. In certain embodiments of the method, the personal care composition is applied topically. In certain embodiments, the personal care composition is applied in an amount ranging from about 5 to about 100 mg / in2of skin, optionally in an amount ranging from about 20 to about 50 mg / in2; about 25 to about 45 mg / in2, or about 30 to about 35 mg / in2.

[0013] According to certain embodiments of the methods disclosed herein, the method enhances delivery of the at least one active ingredient as compared to a personal care composition that does not comprise at least one cross-linked hyaluronic acid by an amount of at least about 5%, at least about 10%, at least about 15%, at least about 20%. at least about 25%, at least about 30%, or at least about 35%.BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Implementation of the present technology will now be described, by way of example only, with reference to the attached figures, wherein:

[0015] FIG. 1 is a bar graph showing carnosine delivery (in |ig) to the skin for a composition comprising 2 wt.% carnosine alone and a composition comprising 2 wt.% carnosine with 1 wt.% Hyacross® cross-linked hyaluronic acid, as disclosed in Example 1.

[0016] FIG. 2 is a bar graph showing arginine delivery (in pgj to the skin for untreated skin, a composition comprising 1 wt.% arginine alone, and a composition comprising 1 wt.% arginine with 3 wt.% Hyacross® cross-linked hyaluronic acid, as disclosed in Example 1.

[0017] FIG. 3 is a bar graph showing arginine delivery (in .g) to the skin for untreated skin, a composition comprising 1 wt.% arginine alone, and a composition comprising 1 wt.% Hyacross® cross-linked hyaluronic acid, as disclosed in Example 1.1096876-00-WG-01-SH

[0018] FIG. 4 is a bar graph showing arginine delivery (in pg) to the skin for untreated skin, a composition comprising 2 wt.% arginine alone and a composition comprising 2 wt.% arginine with 1 wt.% high molecular weight hyaluronic acid, as disclosed in Example 2.

[0019] FIG. 5 is a bar graph showing arginine delivery (in pg) to the skin for untreated skin, a composition comprising 2 wt.% arginine alone and a composition comprising 2 wt.% arginine with 0.03 wt.% high molecular weight hyaluronic acid, as disclosed in Example 2.

[0020] FIG. 6 is a bar graph showing penetration of 0.5 wt.% tocopherol (in pg) alone and 0.5 wt.% tocopherol together with 1 wt.% cross-linked hyaluronic acid to tape strips, epidermis, and dermis, as disclosed in Example 3.

[0021] FIG. 7 is a bar graph showing penetration of to the skin (in pg) of 2 wt.% sodium pyroglutamate (PCA) alone and 2 wt.% sodium PCA together 2 wt.% cross-linked hyaluronic acid, as disclosed in Example 4.

[0022] FIG. 8 is a bar graph showing penetration of to the skin (in pg) of 2 wt.% zinc PCA alone and 2 wt.% zinc PCA together 2 wt.% cross-linked hyaluronic acid, as disclosed in Example 4.

[0023] FIG. 9 is a graph showing the intensity of hyaluronic acid measured at varying depths from the skin surface for a base control composition, a composition without cross-linked hyaluronic acid, and a composition containing 3 wt.% Hyacross®. as disclosed in Example 5.

[0024] FIG. 10 is a graph showing the intensity of hyaluronic acid measured at varying depths from the epidermis for a base control composition and a composition containing 3 wt.% Hyacross®, as disclosed in Example 6.

[0025] It should be understood that the various aspects are not limited to the arrangements and instrumentality shown in the drawings.DETAILED DESCRIPTION

[0026] For illustrative purposes, the principles of the present disclosure are described by referencing various exemplary embodiments thereof. Although certain embodiments of the disclosure are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other apparatuses and methods. Before explaining the disclosed embodiments in detail, it is to be understood that the disclosure is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not of limitation.

[0027] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0028] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5 includes specifically 1, 2, 3, 4 and 5, as well as sub ranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0029] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2.0 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0030] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0031] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the personal care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mb”, “nm”, and “pm” each respectively refer to hour, minute, milliliter, nanometer, and micrometer. The abbreviation “UV-VIS” refers to a spectrometer or spectroscopy, means Ultraviolet-Visible. The abbreviation “rpm” means revolutions per minute.

[0032] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols“=” and “=” mean single bond, double bond, and triple bond, respectively.

[0033] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of, or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such as when reciting a Markush group, the list of species that define or exemplify the genus is open,and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0034] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the personal care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the personal care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added into the personal care composition by itself. For example, a personal care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a blend of two or more compounds.

[0035] As used herein, “substantially free” of a material refers to a composition where the material is present in an amount of less than about 0.1 wt.%, such as less than about 0.05 wt.%. less than about 0.01 wt.%, less than about 0.005 wt.%, less than about 0.001 wt.%, or less than about 0.0001 wt.% based on a total weight of the composition. In certain embodiments, “substantially free” of a material indicates that the material is not present in any detectable amount in the composition.

[0036] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the personal care composition includes both components (or the composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, citric acid may be characterized as both an alpha hydroxy acid and a pH adjuster. If a particular personal care composition includes both an alpha hydroxy acid and a pH adjuster, a compound (e.g., lactic acid) will serve only as either an alpha hydroxy acid or a pH adjuster — not both.

[0037] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjective, the word “group” is assumed. For example, the adjective “alkyl” without a nouns thereafter, should be read as “an alkyl group”.

[0038] Aspects of the present disclosure relate to personal care compositions for improving the health and appearance of skin. The personal care compositions disclosed herein may be formulated to include certain combinations of ingredients in particular amounts and / or ratios that provide enhanced benefits to keratin, particularly skin. In certain embodiments, disclosed herein is apersonal care composition, such a skin care composition and / or a sunscreen composition, comprising cross-linked hyaluronic acid and at least one active ingredient, such as a hydrophilic active ingredient. In certain embodiments, the personal care composition enhances delivery of the at least one active ingredient into the skin as compared to a composition that does not contain cross-linked hyaluronic acid.Cross-linked Hyaluronic Acid

[0039] Hyaluronic acid (HA) is a type of glycosaminoglycan naturally produced in the skin. Hyaluronic acid is a polysaccharide containing N-acetyl-D-glucosamine and P-glucoronic acid, and has well-documented benefits as a powerful moisturizing and hydrating agent. Hyaluronic acid is commonly used in skincare products, where its properties may be determined by its molecular weight. High molecular weight hyaluronic acid, with a molecular weight generally exceeding one megadalton, is believed to be too large to effectively penetrate into the skin and therefore remains on the skin surface, where it may provide hydration benefits. Low molecular weight hyaluronic acid, with a molecular weight typically below about 100 kilodalton, is believed to be capable of effectively penetrating into the skin.

[0040] A unique class of hyaluronic acid is known as cross-linked hyaluronic acid (cross-linked HA), or hyaluronic acid crosspolymer (HA crosspolymer). Cross-linked hyaluronic acid is generated by chemically binding individual linear chains of hyaluronic acid to one another, forming a large, continuous mesh-like structure that effectively has an infinite molecular weight. Because of this exceedingly high molecular weight, cross-linked hyaluronic acid, like linear high molecular weight hyaluronic acid, is believed to remain on the skin surface without penetrating into the skin. However, due to its mesh-like network structure, cross-linked hyaluronic acid has water binding and moisturizing properties that may be considered superior to that of regular, high molecular weight linear hyaluronic acid.

[0041] In particular, cross-linked hyaluronic acid is thought to effectively hydrate the uppermost stratum comeum region of the skin. The stratum corneum contains a highly compact structure of keratinocytes and intercellular lipids arranged in a “brick and mortar” structure, which provides the chief barrier to effective topical delivery of active ingredients into the skin. Without wishing to be bound by theory, it is believed that hydrating this stratum corneum region can “open up” the skin, allowing other active ingredients to permeate into the skin. Accordingly, in the personal care compositions disclosed herein, the cross-linked hyaluronic acid, with its high propensity to retainon the skin surface and form a film-like barrier and hydrate the skin can act as an effective penetration enhancer via its hydration of the stratum corneum, providing superior results as compared to other linear hyaluronic acids having a high molecular weight.

[0042] The cross-linked hyaluronic acid disclosed herein may be any cross-linked hyaluronic acid known in the art. In certain embodiments, the cross-linked hyaluronic acid is an elastomer. In some embodiments, the cross-linked hyaluronic acid elastomer may be a cross-linked hyaluronic acid obtained by cross-linking hyaluronic acid or a salt thereof and the hyaluronic acid salt, e.g., such as a sodium salt, a potassium salt, a zinc salt, a magnesium salt, or a calcium salt of hyaluronic acid. In some embodiments, the cross-linked hyaluronic acid is obtained by crosslinking hyaluronic acids with a crosslinking agent having diepoxide groups as the crosslinkable groups. Additionally or alternatively, the cross-linked hyaluronic acid can be produced using 1,4- butanediol diglycidyl. In certain embodiments, the cross-linked hyaluronic is Hyacross® TL100, available from Bloomage Biotechnology Corp. Ltd. Hyacross® TL100 material contains about 1 wt% to about 5 wt% cross-linked hyaluronic acid elastomer in water to give a clear, jelly-like consistency.

[0043] In certain embodiments, cross-linked hyaluronic acid may be present in the personal care compositions disclosed herein in an amount effective to enhance delivery of at least one active ingredient, e.g., at least one active hydrophilic ingredient in the skin. In certain embodiments, the cross-linked hyaluronic acid may be present in the personal care compositions disclosed herein in an amount ranging from about 0.001 wt.% to about 5 wt.%, such as from about 0.001 wt.% to about 3 wt.%, or about 0.01 wt.% to about 0.05 wt.%. For example, the amount of a cross-linked hyaluronic acid in the personal care composition may be about 0.01 to about 2 wt.%. about 0.01 to about 1.5 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%; from about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1.5 wt.%, about 0.05 to about 1 wt.%. about 0.05 to about 0.5 wt.%; from about 0.1 to about 3 wt.%. about 0.1 to about 2 wt.%, about 0.1 to about 1.5 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.15 to about 3 wt.%, about 0.15 to about 2 wt.%. about 0.15 to about 1.5 wt.%, about 0.15 to about 1 wt.%, about 0.15 to about 0.5 wt.%, including ranges and subranges thereof, based on the total weight of the personal care composition.At least one active ingredient

[0044] In accordance with an aspect of the disclosure, the personal care compositions disclosed herein comprise, in addition to the at least one cross-linked hyaluronic acid, further comprise at least one active ingredient. The at least one active ingredient may be any active ingredient that is desirably delivered into the skin and whose delivery into the skin can be enhanced through the cross-linked hyaluronic acid. In certain embodiments, the at least one active ingredient is a hydrophilic active ingredient.

[0045] In certain embodiments, the at least one active ingredient is selected from amino acids and peptides, and in certain embodiments, the at least one active ingredient is selected from hydrophilic amino acids and peptides. Any amino acid may be incorporated in the personal care compositions disclosed herein, including for example, arginine, histidine, glutamine, methionine, lysine, proline, leucine, and glycine. In certain embodiments, the personal care compositions disclosed herein comprise at least one hydrophilic amino acid selected from arginine, asparagine, aspartate, glutamine, glutamate, histidine, lysine, serine, and threonine. In certain embodiments, the at least one hydrophilic amino acid is arginine.

[0046] In certain embodiments, the at least one active ingredient in the personal care compositions may include at least one peptide. Any peptide known in the art for use in skin care may be selected, including, for example, dipeptides, tripeptides, and heptapeptides. In certain embodiments, the at least one peptide may be a hydrophilic peptide, and in certain embodiments, the at least one peptide may be a hydrophilic dipeptide, such as carnosine.

[0047] The tripeptides may be selected from those of the sequences Gly-His-Lys, analogs thereof, derivatives thereof, and combinations of two or more thereof. The tetrapeptides may be selected from those of the sequence Gly-Gln-Pro-Arg, its analogs, derivatives thereof, and combinations of two or more thereof. The tetrapeptides may have one or more amino acid including an aliphatic group side chain, one or more amino acid including at least one Nt -containing side chain, and / or at least amino acid including at least one cationic amine (NHs+, NH2+, etc.) containing side chain, as well as acyl derivatives of these, and / or combinations thereof.

[0048] Examples of peptides that are capable of improving the health of skin include TGF-P mimic bioactive peptides, such as those selected from TGF-P mimics, analogs of TGF-P mimics, derivatives of TGF-p mimics, and mixtures thereof. The TGF-p mimic peptides may have the following initial amino acid sequence, AAi-AAi+l-AAi+2 wherein AAi is alanine, asparagine, or1096876-00-WG-01-SH leucine, AAi+1 is valine or isoleucine, and AAi+2 is alanine. The TGF-0 mimic peptides preferably reactivate TGF-0 signaling in damaged cells, resulting in both tissue repair and normal tissue homeostasis.

[0049] Additional peptides that are worth noting include acetyl hexapeptide; palmitoyl tripeptide- 3; palmitoyl oligopeptide; palmitoyl tetrapeptide-7; dipeptide diaminobutyroyl benzylamide diacatate; acetyl glutamyl heptapeptide- 1 ; and combinations of two or more thereof. Acetyl hexapeptide-3 is a synthetic peptide comprised of the six amino acids: Glutamic Acid-Glutamic Acid-Methionine-Glutamine- Arginine- Arginine (Glu-Glu-Met-Gln- Arg-Arg). Acetyl hexapeptide-3 is an oligopeptide that functions as a catecholamine inhibitor and a muscle relaxant. Palmitoyl tripeptide-3 (or palmitoyl oligopeptide) is a peptide comprised of 3 amino acids: Glycine-Histidine-Lysine (N-palmitoyl-Gly-His-Lys). Palmitoyl tripeptide may be used individually or in combination with one or more of the amino acids or peptides described herein. Palmitoyl tetrapeptide-7 is a peptide comprised of four amino acids: Glycine-Glutamine-Proline- Arginine (N-palmitoyl-Gly-Gln-Pro-Arg). A blend of palmitoyl oligopeptide (palmitoyl tripeptide) and palmitoyl tetrapeptide-7 when delivered in a mixture functions as a dermal stimulating and / or regenerating composition. Dipeptide diaminobutyroyl benzylamide diacetate is a synthetic peptide comprised of the following sequence: H-beta-ala-pro-dab-NHBzl (x2 AcOH). Dipeptide diaminobutyroyl benzylamide diacatate is an oligopeptide that functions as an anticholinergic and a muscle relaxant. Acetyl glutamyl heptapeptide- 1 is a peptide comprised of the eight amino acids: Acetyl glutamyl-glutamyl-methionyl-glutaminyl-arginyl-arginyl-alanyl- aspartylamide.

[0050] In embodiments disclosed herein, the at least one amino acid (e.g., arginine) or peptide (e.g., carnosine) may be present in the personal care composition in an amount ranging from about 0.01 wt.% to about 10 wt.%, such as from about 0.1 wt.% to about 7 wt.%, about 1 wt.% to about 5 wt.%. about 1 wt.% to about 4 wt.%, about 1 wt.% to about 3 wt.%, about 1 wt.% to about 2 wt.%, about 2 wt.% to about 5 wt.%, about 2 wt.% to about 4 wt.%, about 2 wt.% to about 3 wt.%, about 1 wt.%, about 2 wt.%, or about 3 wt.%, by weight based on a total weight of the personal care composition.

[0051] In certain embodiments, the at least one active ingredient in the personal care composition is a vitamin, such as a hydrophilic vitamin. Exemplary hydrophilic vitamins that may be used in the context of the present disclosure include, for example vitamin C and vitamin B, such asthiamine, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folate, and / or cobalamin. When present, the at least one vitamin may be present in the personal care composition in an amount ranging from about 0.01 wt.% to about 10 wt.%. such as from about 0.1 wt.% to about 7 wt.%, about 1 wt.% to about 5 wt.%, about 1 wt.% to about 4 wt.%, about 1 wt.% to about 3 wt.%, about 1 wt.% to about 2 wt.%, about 2 wt.% to about 5 wt.%, about 2 wt.% to about 4 wt.%, about 2 wt.% to about 3 wt.%, about 1 wt.%, about 2 wt.%, or about 3 wt.%, by weight based on a total weight of the personal care composition.

[0052] In certain embodiments, the at least one active ingredient may include a linear hyaluronic acid, such as at least one low molecular weight linear hyaluronic acid, at least one medium molecular weight linear hyaluronic acid, and / or at least one high molecular weight linear hyaluronic acid. In embodiments wherein the at least one active ingredient is a hyaluronic acid, the hyaluronic acid is not cross-linked and is present in addition to the at least one cross-linked hyaluronic acid in the personal care composition. The at least one active ingredient that is a hyaluronic acid may comprise a non-chemically modified hyaluronic acid, a chemically modified hyaluronic acid, and / or a hydrolyzed hyaluronic acid. In certain embodiments, the at least one active ingredient may comprise or consist of one hyaluronic acid, and in certain embodiments, the at least one active ingredient may comprise more than one hyaluronic acid (e.g„ linear, non-cross- linked hyaluronic acid), such as at least 2, at least 3, at least 4, at least 5, at least 6, or at least 7 hyaluronic acids.

[0053] The at least one low molecular weight hyaluronic acid may have a molecular weight up to 50,000 Da. For instance, the personal care compositions may have a hyaluronic acid having a molecular weight from about 1,000 to 50,000 Da, about 5.000 to 50,000 Da, about 10,000 to 50,000 Da, about 15,000 to 50,000 Da, about 20,000 to 50,000 Da, about 25,000 to 50,000 Da, about 30,000 to 50,000 Da, about 35,000 to 50,000 Da, about 40,000 to 50,000 Da; from about 1,000 to about 45.000 Da, about 5.000 to about 45.000 Da, about 10,000 to about 45,000 Da, about 15,000 to about 45,000 Da, about 20,000 to about 45,000 Da, about 25,000 to about 45,000 Da, about 30,000 to about 45,000 Da, about 35,000 to about 45,000 Da, about 40,000 to about 45,000 Da; from about 1,000 to about 40,000 Da, about 5,000 to about 40,000 Da, about 10,000 to about 40,000 Da, about 15,000 to about 40,000 Da, about 20,000 to about 40,000 Da, about 25,000 to about 40,000 Da, about 30,000 to about 40,000 Da. about 35,000 to about 40,000 Da; from about 1,000 to about 35,000 Da, about 5,000 to about 35,000 Da, about 10,000 to about 35,000 Da, about15,000 to about 35,000 Da, about 20,000 to about 35,000 Da, about 25,000 to about 35,000 Da, about 30,000 to about 35,000 Da; from about 1,000 to about 30,000 Da, about 5,000 to about 30,000 Da, about 10,000 to about 30,000 Da. about 15,000 to about 30,000 Da, about 20,000 to about 30,000 Da, about 25,000 to about 30,000 Da; from about 1,000 to about 25,000 Da, about 5,000 to about 25,000 Da, about 10,000 to about 25,000 Da, about 15,000 to about 25,000 Da, about 20.000 to about 25,000 Da; from about 1,000 to about 20,000 Da. about 5.000 to about 20,000 Da, about 10,000 to about 20,000 Da, about 15,000 to about 20,000 Da; from about 1,000 to about 20,000 Da, about 5,000 to about 20,000 Da, about 10,000 to about 20,000 Da, or about 15,000 to about 20,000 Da, including ranges and subranges thereof.

[0054] The at least one medium molecular weight hyaluronic acid may have a molecular weight ranging from about 50,000 to 400,000 Da. In some embodiments, the medium molecular weight hyaluronic acid(s) has a molecular weight of about 50,000 to 400,000 Da, about 100,000 to 400,000 Da, about 125,000 to 400,000 Da, about 150,000 to 400,000 Da, about 170,000 to 400,000 Da, about 200.000 to 400,000 Da; from about 50,000 to 350.000 Da, about 100,000 to 350,000 Da, about 125,000 to 350,000 Da, about 150,000 to 350,000 Da, about 170,000 to 350,000 Da, about 200,000 to 350,000 Da; from about 50,000 to 320,000 Da, about 100,000 to 320,000 Da, about 125,000 to 320,000 Da, about 150,000 to 320,000 Da, about 170,000 to 320,000 Da, or about 200,000 to 320,000 Da, including any range or subrange thereof.

[0055] The at least one high molecular weight hyaluronic acid may have a molecular weight of greater than 400,000 Da. For instance, the personal care composition may include one or more high molecular weight hyaluronic acid having a molecular weight ranging from 400,000 Da to about 6,000,000 Da, 400,000 Da to about 4,000,000 Da, 400,000 Da to about 2,000,000 Da, 400,000 Da to about 1 ,000,000 Da, 400,000 Da to about 800,000 Da, 400,000 Da to about 600,000 Da; from about 600,000 Da to about 6,000,000 Da, about 600,000 Da to about 4,000,000 Da, about 600,000 Da to about 2,000,000 Da. about 600.000 Da to about 1.000,000 Da. about 600.000 Da to about 800,000 Da; from about 800,000 Da to about 6,000,000 Da, about 800,000 Da to about 4,000,000 Da, about 800,000 Da to about 2,000,000 Da, about 800,000 Da to about 1,000,000 Da; from about 1,000,000 Da to about 6,000,000 Da, about 1,000,000 Da to about 4,000,000 Da, or about 1,000,000 Da to about 2,000,000 Da, including ranges or ranges thereof.

[0056] In certain embodiments of the disclosure, the personal care composition disclosed herein is free of or substantially free of a high molecular weight hyaluronic acid.

[0057] In embodiments wherein the at least one active ingredient comprises a hyaluronic acid that is not a cross-linked hyaluronic acid (e.g., a medium weight linear hyaluronic acid), the hyaluronic acid may be present in the personal care composition in any effective amount. In certain embodiments, the hyaluronic acid may be present in the personal care compositions disclosed herein in an amount ranging from about 0.001 wt.% to about 5 wt.%, such as from about 0.001 wt.% to about 3 wt.%. or about 0.01 wt.% to about 0.05 wt.%, by weight based on a total weight of the personal care composition. For example, the amount of a cross-linked hyaluronic acid in the personal care composition may be about 0.01 to about 2 wt.%, about 0.01 to about 1.5 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%; from about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1.5 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.5 wt.%; from about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1.5 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.15 to about 3 wt.%, about 0.15 to about 2 wt.%, about 0.15 to about 1.5 wt.%, about 0.15 to about 1 wt.%, about 0.15 to about 0.5 wt.%, including ranges and subranges thereof, based on the total weight of the personal care composition.

[0058] In certain embodiments disclosed herein, the at least one active ingredient is selected from a humectant. Humectants may be used, for example, to moisturize skin and prevent or reduce moisture loss from the skin. Suitable humectants may include, but are not limited to, phospholipids (e.g., lecithin, panthenol. glycerin), aloe vera, sorbitol, urea, collagen, honey, alpha-hydroxy acids, sodium pyroglutamate, N-acetyl-ethanolamine, sodium lactate, isopropanol, polyalkylene glycols (e.g., ethylene glycol, propylene glycol, hexylene glycol, butylene glycol, dipropylene glycol, triethylene glycol, tripropylene glycol), 1,3-propanediol, 1.2-hexanediol, polyethylene glycols, synthetic alcohols (e.g., glyceryl coconate, hydroxystearate, myristate, oleate), saccharide isomerate, and any combinations thereof. In certain embodiments, the humectant is a hydrophilic humectant, and in certain embodiments, the humectant is sodium pyroglutamate (PCA).

[0059] When present, the humectant (e.g., sodium PCA) may be present in the personal care composition in an amount ranging from about 0.01 wt.% to about 10 wt.%, such as from about 0.1 wt.% to about 7 wt.%, about 1 wt.% to about 5 wt.%, about 1 wt.% to about 4 wt.%, about 1 wt.% to about 3 wt.%, about 1 wt.% to about 2 wt.%, about 2 wt.% to about 5 wt.%, about 2 wt.% to about 4 wt.%, about 2 wt.% to about 3 wt.%, about 1 wt.%, about 2 wt.%, or about 3 wt.%, by weight based on a total weight of the personal care composition.

[0060] Suitable components, such as those listed herein, may be included or excluded from the formulations of the personal care compositions disclosed herein depending on, e.g., the specific combination of other ingredients, the form of the personal care compositions, and / or the use of the compositions (e.g., a lotion, cream, spray, serum etc.). The personal care compositions may be a skin care compositions that is specifically formulated for topical application to a user’s skin. The personal care compositions may be in the form of an oil-in-water emulsion or water-in-oil emulsion that includes a fatty and / or hydrophobic phase and an aqueous and / or hydrophilic phase.

[0061] In certain embodiments, the personal care composition is a skin care composition. In some embodiments, the personal care composition is a leave-on composition. In some embodiments, the leave-on composition is a cream, lotion, or serum. In other embodiments, the composition is a rinse-off composition. In some embodiments, the rinse-off composition is a liquid soap, hand soap, face soap, shower gel, body wash, shampoo, or hair conditioner.

[0062] In certain embodiments, the personal care compositions disclosed herein further comprise optional ingredients in addition to the at least one cross-linked hyaluronic acid and the at least one active ingredient. Optional ingredients that may be included in the personal care composition include solvents; water-soluble alcohols such as C2-8 alcohols including ethanol; glycols including propylene glycol, dipropylene glycol, tripropylene glycol and mixtures thereof; glycerides including mono-, di- and triglycerides; medium to long chain organic acids, alcohols and esters; surfactants including emulsifying and dispersing agents; amino acids including glycine; structurants including thickeners and gelling agents, for example polymers, silicates and silicon dioxide; emollients; fragrances; and colorants including dyes and pigments.

[0063] In certain embodiments, the personal care compositions include at least one thickening agent. The personal care compositions may include a total amount of thickening agents ranging from about 0.1 wt.% to about 10 wt.%, based on the total weight of the personal care composition. For instance, the at least one thickening agent may be present in the personal care compositions in an amount ranging from about 0.1 to about 9 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 7 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.1 to about 10 wt.%, about 0.1 to about 9 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 7 wt.%, or about 0.1 to about 5 wt.%.

[0064] Examples of humectants that may be incorporated in certain embodiments in addition to or instead of the at least one active ingredient may include triethylene glycol, tripropylene glycol, propylene glycol, glycerin, polyethylene glycols, PPG. glycerin, sorbitol, hexylene glycol, butylene glycol, urea, collagen, aloe, honey, hyaluronic acid, 1,2 hexanediol, saccharide isomerate and a combination of two or more thereof.

[0065] Additional examples of humectants include certain polyols and / or glycols. The term “polyol” should be understood as meaning, within the meaning of the present disclosure, an organic molecule comprising at least two free hydroxyl groups. The polyols of the personal care composition may be glycols or compounds with numerous hydroxyl groups. In some cases, the one or more polyols is / are selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms. Non-limiting examples of polyols that may be included in the personal care composition, in certain instances, include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, diglycerin, diethylene glycol, and dipropylene glycol, and mixtures thereof.

[0066] The personal care compositions may include one or more alpha hydroxy acid. The alpha hydroxy acids may be present in the personal care compositions in an amount of about 0.05 to about 10 wt.%, based on the total weight of the personal care composition. For example, the alpha hydroxyl acid(s) may be present in the personal care compositions in an amount ranging from about 0.05 to about 8 wt.%, about 0.05 to about 6 wt.%, about 0.05 to about 5 wt.%, about 0.05 to about 4 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.5 wt.%; from about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%. about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%. about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%,about 2 to about 6 wt.%, about 2 to about 5 wt.%, or about 2 to about 4 wt.%, including any ranges or subranges thereof, based on the total weight of the personal care composition.

[0067] The one or more alpha-hydroxy acids may be selected from C3 to C7 alpha-hydroxy acids, C4 to G, alpha-hydroxy acids, and / or salts thereof. Although the personal care compositions may include a salt of an alpha-hydroxy acid, in some embodiments the personal care composition is substantially free of or free of a salt of an alpha-hydroxy acid. For example, the personal care composition may be formulated such that the total amount of alpha hydroxy acid(s) and salt(s) thereof is comprised of at least about 50%, at least about 60%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, or at least about 95% of alpha hydroxy acid(s), based on the total weight of the alpha hydroxy acid(s) and salt(s) thereof.

[0068] Non-limiting examples of alpha-hydroxy acids and / or salts thereof include but are not limited to, mandelic acid, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, phytic acid, hydroxycaprylic acid, hydroxycapric acid, glutaric acid, gluconic acid, salt(s) thereof, or a combination of two or more thereof. In some embodiments, the alpha-hydroxy acids are citric acid, mandelic acid, glycolic acid, lactic acid or a combination of two or more thereof. In certain instances, the alpha-hydroxy acid is selected from malic acid, tartaric acid, alpha- hydroxy glutaric acid, gluconic acid, a salt thereof, and a combination of two or more thereof. Yet in further instances, the alpha-hydroxy acid or salt thereof is selected from lactic acid, malic acid, sodium- D-gluconate, a salt thereof, and a combination of two or more thereof. In additional instances, the alpha-hydroxy acid is lactic acid and / or a salt thereof. In yet further instances, the one or more alpha-hydroxy acid comprises glycolic acid and / or a salt thereof and lactic acid and / or a salt thereof. In at least one instance, the alpha-hydroxy acid and / or salt thereof comprises glycolic acid, lactic acid, citric acid, a salt thereof, or a combination thereof.

[0069] The personal care formulation may, optionally, comprise one or more beta-hydroxy acid(s) and / or salt(s) thereof. Non-limiting examples of beta-hydroxy acids include salicylic acid, propionic acid, beta-hydroybutyric acid, beta-hydroxy beta-methylbutyric acid, carnitine, a salt thereof, and a combination of two or more thereof. The beta-hydroxy acids may in some cases be selected from salicylic acid, esters of salicylic acid, sodium salicylate, beta hydroxybutanoic acid, tropic acid, trethocanic acid, beta hydroxyl acids obtained from white willow bark extract and / or Wintergreen leaves, salts thereof, and combinations of two or more thereof. In some embodiments,the beta-hydroxy acid(s) comprises salicylic acid, sodium salicylate, beta hydroxyl acids of willow bark extract, salts thereof or combinations of two or more thereof.

[0070] The amount of beta-hydroxy acid, if present, in the personal care composition may be in an amount from about 0.05 to about 10 wt.%, relative to the total weight of the personal care composition. For example, the beta hydroxyl acid(s) may be present in the personal care compositions in an amount ranging from about 0.05 to about 8 wt.%, about 0.05 to about 6 wt.%, about 0.05 to about 5 wt.%, about 0.05 to about 4 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.5 wt.%; from about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.1 to about 10 wt.%. about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about3 wt.%, about 0.1 to about 2 wt.%. about 0.1 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%. about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, or about 2 to about 4 wt.%, including any ranges or subranges thereof, based on the total weight of the personal care composition.

[0071] The personal care composition may include one or more pH adjusters to increase or decrease the overall pH of the personal care composition. For example, one or more acids may be included to decrease the pH of the personal care composition. Examples of suitable acids for decreasing the pH of the personal care composition include, but are not limited to, citric acid, acetic acid, and the like. The personal care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the personal care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the personal care composition are readily known to one of ordinary skill in the art.

[0072] The amount of the pH adjuster in the personal care composition may be based on the desired pH of the final personal care composition and / or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 50 wt.%, based on the total weight of thepersonal care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 20 wt.%, about 0.05 to about 15 wt.%, about 0.1 to about 10 wt.%, or about 0.12 to about 5 wt.%. including ranges and sub-ranges therebetween, based on the total weight of the personal care composition.

[0073] In certain embodiments, the personal care composition has a pH of from about 2 to about 7. For example, the pH of the personal care composition may be from about 2 to about 7. about 2 to about 6.5, about 2 to about 6, about 2 to about 5.5, about 2 to about 5, about 2 to about 4.5, about 2 to about 4, about 2 to about 3.5; from about 3 to about 7, about 3 to about 6.5, about 3 to about 6, about 3 to about 5.5, about 3 to about 5, about 3 to about 4.5, about 3 to about 4; from about 4 to about 7, about 4 to about 6.5, about 4 to about 6, about 4 to about 5.5, about 4 to about 5; from about 4.5 to about 7, about 4.5 to about 6.5, about 4.5 to about 6, about 4.5 to about 5.5; from about 5 to about 7, about 5 to about 6.5, about 5 to about 6; from about 5.5 to about 7, or about 5.5 to about 6.5, including ranges and subranges thereof. In at least one embodiment, the pH of the personal care composition is about 4.5 to about 6.5 or about 5 to about 6.

[0074] The personal care composition may have a viscosity of from about 2,000 to about 50,000 centipoise (cP), about 2,000 to about 20,000 cP, or about 3,000 to about 16,000 cP, or about 4,000 to about 12,000 cP, including all values in between these ranges, at room temperature using Brookfield viscometer with a Spindle 4 at a speed of 20 rpm. Additionally or alternatively, the personal care composition may have a viscosity of from about 2,000 to about 50,000 centipoise (cP), at room temperature using Brookfield viscometer with a Spindle C at a speed of 12 rpm.

[0075] Additional ingredients may be present in the personal care composition. These include water and ingredients to thicken, preserve, emulsify, add fragrance, adjust the pH, and color. The personal care compositions may include any of the following additional ingredients in an amount of from about 0.01 to about 5 wt.%. In some instances, the amount of additional ingredients present in the personal care composition is from about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.1 wt.%; about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1 wt.%;1096876-00-WG-01-SH about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%. or about 3 to about 4 wt.%, including any range or subrange therebetween, based on the total weight of the personal care composition.

[0076] The personal care composition can comprise additional ingredients, such as proteins (e.g., hydrolyzed vegetable protein, hydrolyzed wheat protein, hydrolyzed milk protein, hydrolyzed silk and hydrolyzed collagen), vitamins (e.g., panthenol, biotin, vitamin E acetate, vitamin A and D palmitate), and emollients (e.g.. esters, isopropyl myristate, decyl oleate, C12-15 alkyl benzoate), as well as preservatives, dyes, pH adjusters and chelating agents. Additional examples of vitamins that may be included in some personal care compositions include tocopherol, retinol, and ascorbic acid. Vitamin derivatives, such as ascorbyl monopalmitate, tocopheryl acetate, and Vitamin E palmitate, may also be included in certain embodiments.

[0077] Panthenol may be incorporated into personal care compositions and may function within a personal care composition of the disclosure by readily penetrating the skin to help deliver the active agents to a site of action and to soothe and moisturize the skin. Panthenol derivatives (e.g., ethyl panthenol) may also be used in the personal care compositions as well as other agents such as provitamins B5 and E, as well as their derivatives, aloe vera (e.g., for soothing the skin), allantoin (e.g., for both soothing and softening of the skin), bisabolol (e.g., for soothing the skin), dipotassium glycyrrhizinate, pantothenic acid and its derivatives, as well as Sorbitol (e.g.. for moisturizing the skin).

[0078] Non-limiting examples of fragrances and perfumes include odor compounds selected from: 7-acetyl-l,2,3,4,5,6,7,8-octahydro-1.1.6.7-tetramethylnaphthalene, a-ionone. P-ionone. y-ionone a-isomethylionone, methylcedrylone, methyl dihydrojasmonate, methyl l,6,10-trimethyl-2,5,9- cyclododecatrien- 1 -yl ketone, 7-acetyl- 1 , 1 ,3,4,4,6-hexamethyltetralin, 4-acetyl-6-tert-butyl- 1,1- dimethylindane, hydroxyphenylbutanone, benzophenone, methyl P-naphthyl ketone, 6-acetyl- 1,1,2,3,3,5-hexamethylindane, 5-acetyl-3-isopropyl-l,l,2,6-tetramethylindane, 1-dodecanal, 4-(4- hydroxy-4-methylpentyl)-3-cyclohexene-l-carboxaldehyde, 7-hydroxy-3,7-dimethyloctanal, 10- undecen-l-al, isohexenylcyclohexylcarboxaldehyde, formyltricyclodecane, condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxycitronellal and indole, condensation products of phenylacetaldehyde and indole, 2-methyl- 3-(para-tert-butylphenyl)propionaldehyde, ethylvanillin, heliotropin, hexylcinnamaldehyde,amylcinnamaldehyde, 2-methyl-2-(isopropylphenyl)propionaldehyde, coumarin, y-decalactone, cyclopentadecanolide, 16-hydroxy-9-hexadecenoic acid lactone, 1,3,4,6,7,8-hexahydro- 4,6,6,7,8,8-hexamethylcyclopenta-y-2-benzopyran, P-naphthol methyl ether, ambroxane, dodecahydro-3a,6,6,9a-tetramethylnaphtho[2, lb]furan, cedrol, 5-(2,2,3-trimethylcyclopent-3- enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-l-yl)-2-buten-l-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate, and tert-butylcyclohexyl acetate.

[0079] Other fragrances may include odor compounds selected from essential oils, resinoids and resins from a large number of sources, such as, for example, Peru balsam, olibanum resinoid, styrax, labdanum resin, nutmeg, cassia oil, benzoin resin, coriander, and lavandin.

[0080] Further suitable fragrances include odor compounds selected from phenylethyl alcohol, terpineol, linalool, linalyl acetate, geraniol, nerol, 2-(l,l-dimethylethyl)cyclo-hexanol acetate, benzyl acetate, and eugenol. The fragrances or perfumes can be used as single substances or in a mixture with one another.

[0081] The personal care composition may further comprise one or more colorants. The colorants may be a pigment, a dye, or mixtures thereof. Non- limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica, etc. Non-limiting examples of dyes include food dyes suitable for food, drug and cosmetic applications, and mixtures thereof. Some color agents (colorants) are known as FD&C dyes.

[0082] The colorants may be present in an amount ranging from about 0.0001 wt.% to about 0.4 wt.%, including all percentages and subranges therebetween, based on the total weight of the personal care composition. In some embodiments, the colorants may be present in an amount ranging from about 0.0001 wt.% to about 4 wt.%, including all percentages and subranges therebetween, based on the total weight of the personal care composition.

[0083] In certain embodiments, in order to prevent ingredients from separating, emulsifiers may be added. In certain embodiments, additional ingredients may include conditioning agents that moisturize the skin or leave the skin with a desirable tactile effect during and after use of the personal care composition. A variety of emollients may also be included as additional ingredients, such as neopentyl glycol dicaprylate / dicaprate-ester, dimethicone, tridecyl trimellitate, and other such suitable emollients known in the art. Other skin conditioning / soothing agents can be included in the subject compositions, some of which are discussed below. For instance, one or more of the1096876-00-WG-01-SH following may be included: Bis-PEG-18 methyl ether dimethyl silane, squalane, PEG 3350, phospholipids, sodium hyaluronate, behenyl alcohol, Butyrospermum Parkii (Shea Butter), Cyclomethicone. Lactobacillus / Eriodictyon Califomicum Ferment Extract and the like, Methyl Gluceth-20, Primus amygdalus dulcis (Sweet Almond) Oil, Sodium Lactate, Borago Officinalis (Borage) Seed Oil, Persea Gratissima (Avocado) Oil, Vitamin D and its derivatives, Caprylic / Capric Triglyceride, and the like. Other additional ingredients that may be beneficial and may be included in the personal care compositions disclosed herein, for example, lanolin oil, lanolin alcohol, ceramide, urea, trehalose, mannan, and the like.

[0084] In other embodiments, the personal care composition may include any of following materials in any desired amount to achieve a desired effect in the composition (amounts that can be used in some embodiments are provided): one or more alkaline salts, for example, sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate and / or their equivalents (0 to 5% by weight); sequestrants, for example, tetrasodium EDTA, and / or their equivalents (0 to 2% by weight); biocides, for example, Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), DMDM hydantoin, formaldehyde and / or imidazolidinyl urea, and / or their equivalents (0 to 2% by weight); organic acids, for example, citric acid and / or formic acid and / or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and / or perfumes (0 to 5% by weight); preservatives, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid (0 to 2% by weight); pearlizing agents, for example, glycol distearic esters, such as ethylene glycol distearate, but also fatty acid monoglycol esters (0 to 3% by weight); stabilizers, for example, metal salts of fatty acids, such as e.g. magnesium stearate, aluminum stearate and / or zinc stearate (0 to 2% by a weight); and dyes and pigments that are approved and suitable for cosmetic purposes.

[0085] The personal care compositions may include water in an amount from about 1 to about 95 wt.%. based on the total weight of the personal care composition. For example, the water may be present in the personal care composition in an amount from about 5 to about 95 wt.%, about 10 to about 95 wt.%, about 15 to about 95 wt.%, about 20 to about 95 wt.%, about 30 to about 95 wt.%, about 40 to about 95 wt.%, about 50 to about 95 wt.%, about 60 to about 95 wt.%, about 70 to about 95 wt.%, about 80 to about 95 wt.%, about 90 to about 95 wt.%; about 5 to about 90 wt.%, about 10 to about 90 wt.%. about 15 to about 90 wt.%, about 20 to about 90 wt.%, about 30 to about 90 wt.%, about 40 to about 90 wt.%, about 50 to about 90 wt.%, about 60 to about 90 wt.%,about 70 to about 90 wt.%, about 80 to about 90 wt.%; about 5 to about 80 wt.%, about 10 to about 80 wt.%, about 15 to about 80 wt.%, about 20 to about 80 wt.%, about 30 to about 80 wt.%, about 40 to about 80 wt.%, about 50 to about 80 wt.%, about 60 to about 80 wt.%, about 70 to about 80 wt.%, about 75 to about 80 wt.%; about 5 to about 70 wt.%, about 10 to about 70 wt.%, about 15 to about 70 wt.%, about 20 to about 70 wt.%, about 30 to about 70 wt.%, about 40 to about 70 wt.%. about 50 to about 70 wt.%, about 60 to about 70 wt.%; about 5 to about 60 wt.%, about 10 to about 60 wt.%, about 15 to about 60 wt.%, about 20 to about 60 wt.%, about 30 to about 60 wt.%, about 40 to about 60 wt.%, about 50 to about 60 wt.%; about 5 to about 50 wt.%, about 10 to about 50 wt.%, about 15 to about 50 wt.%, about 20 to about 50 wt.%, about 30 to about 50 wt.%, about 40 to about 50 wt.%, including any ranges and subranges therebetween, based on the total weight of the personal care composition.

[0086] In various embodiments of the disclosure, the personal care composition disclosed herein comprising at least one cross-linked hyaluronic acid enhances delivery of the at least one active ingredient (e.g„ at least one hydrophilic active ingredient) as compared to a personal care composition that does not contain at least one cross-linked hyaluronic acid. For example, in certain embodiments, the personal care composition disclosed herein comprising at least one cross-linked hyaluronic acid enhances delivery of the at least one active ingredient (e.g., at least one hydrophilic active ingredient) as compared to a personal care composition that does not contain at least one cross-linked hyaluronic acid by at least about 2%, such as at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, or at least about 35%.

[0087] The personal care compositions disclosed herein may be manufactured using methods known in the art. Typically, the ingredients are combined and optionally heated where components need to be melted. The components are mixed. Desirably, volatile materials such as fragrant materials are incorporated in the personal care composition in the latter stages of a mixing cycle in order to avoid volatilization thereof. After mixing, the personal care composition may be poured directly into the dispensers and the container capped to preserve the product until use.

[0088] Also disclosed herein is a method of delivering at least one active ingredient into the skin of a subject, the method comprising applying the composition disclosed herein to the skin in an effective amount. In certain embodiments, the amount of the personal care composition applied to the skin may range from about 5 to about 100 milligrams per square inch (g / in2) of skin. In some cases, the amount of personal care composition applied to the skin is about 20 to about 50 mg / in2;about 25 to about 45 mg / in2, about 30 to about 40 mg / in2, or about 30 to about 35 mg / in2, including any ranges or subranges therebetween. The personal composition may be spread on the skin by hand, or it may be done by an instrument such as a glove or a piece of cloth. In the methods disclosed herein, the personal care composition may be rubbed into the skin and is not rinsed off, e.g., is allowed to dry on the skin. In certain embodiments, the personal care composition may be rinsed off after a period of time, such as after about 1 minute, after about 5 minutes, after about 10 minutes, or after about 30 minutes. In the methods disclosed herein, the personal care composition can be applied to the subject’s skin in any effective amount.

[0089] In the methods disclosed herein, the personal care composition may enhance delivery of the at least one active ingredient into the skin of the user as compared to a composition that does not comprise at least one cross-linked hyaluronic acid or does not comprise an effective amount of at least one cross-linked hyaluronic acid. In various embodiments, the methods disclosed herein enhance delivery of the composition into the epidermis, such as into basal lamina, the spinosal layer, the granular layer, and / or the stratum comeum, and in certain embodiments, the methods disclosed herein enhance delivery of the composition into the dermis. According to methods disclosed herein, the personal care composition may be applied topically, e.g., is not administered via one or more injections. In various embodiments of the disclosure, the methods disclosed herein enhance delivery of the at least one active ingredient (e.g., at least one hydrophilic active ingredient) as compared to a personal care composition that does not contain at least one crosslinked hyaluronic acid. For example, in certain embodiments, the methods disclosed herein enhance delivery of the at least one active ingredient (e.g., at least one hydrophilic active ingredient) as compared to a personal care composition that does not contain at least one crosslinked hyaluronic acid by at least about 2%, such as at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, or at least about 35%.EXAMPLESExample 1 - Cross-linked Hyaluronic Acid and Delivery of Amino Acids

[0090] A base composition was prepared as shown in Table 1 below. To prepare the base composition, potassium sorbate, sodium benzoate, and caprylyl glycol were added to a batch composition, heated to 30 °C, and stirred until the mixture was homogeneous. Sodium carboxymethyl starch was added and the batch mixed until homogenous. The pH was thenmeasured and the composition adjusted with citric acid (50%) and sodium citrate (25%) as necessary to reach a final pH ranging from 5.5-6.5.

[0091] Table 1 - Base composition

[0092] To this base composition was added either 2 wt.% carnosine alone (Composition A) or 2 wt.% carnosine in combination with 1 wt.% of a cross-linked hyaluronic acid (Hyacross® TL100 from Bloomage Biotechnology Corp. Ltd.) (Composition B). Hyacross® TL100 comprises about 1-5 wt.% cross-linked hyaluronic acid in water, such that the final Composition B contained about 2 wt.% carnosine and about 0.01 wt.% to about 0.05 wt.% cross-linked hyaluronic acid. Additionally, Composition C was prepared containing 1 wt.% arginine, and Composition D was prepared containing 1 wt.% arginine and 3 wt.% Hyacross® TL100 (z.e., 0.03 to 0.15 wt.% crosslinked hyaluronic acid). The compositions are shown below in Table 2.

[0093] Table 2 - Compositions comprising camosine or arginine

[0094] The dermal delivery of each composition into porcine skin was assessed. To assess the dermal delivery, skin penetration studies were conducted for 24 hours on a DHC-6T Franz cell unit from Logan Technologies (Somerset, NJ). Active content of arginine or carnosine in the skin was measured using an Agilent 1200 or Agilent 1260 HPLC unit equipped with a UV-Vis detector.1096876-00-WG-01-SHCarnosine could be detected directly, while arginine required derivatization as it possesses minimal inherent UV absorption.

[0095] The results are shown in FIG. 1 (carnosine) and FIG. 2 (arginine). For both camosine and arginine, the inclusion of cross-linked hyaluronic acid led to a noted increase in the level of active ingredient delivered into the skin. For camosine (FIG. 1), the addition of 1 wt.% Hyacross® TL100 to a formula containing 2 wt.% carnosine led to a significant increase (p = 0.012) in the amount of carnosine that was delivered past the stratum comeum and into deeper regions of the skin, as compared to a composition not containing Hyacross® TL100. Composition A lead to carnosine delivery of 135.80 ± 15.35 pg, as compared to Composition B, which lead to 186.83 ± 22.46 pg of camosine delivery.

[0096] For arginine, untreated skin was also included in the testing, as the porcine skin contains a significant level of endogenous arginine that was accounted for. The addition of 3 wt.% crosslinked Hyacross® TL100 to a formula containing 1 wt.% arginine caused a large increase in the level of active delivered (54.46 ± 14.49 pg) beyond the stratum corneum and into the deeper regions of the skin, as compared to 1 wt.% arginine in the absence of cross-linked hyaluronic acid (32.37 ± 12.81 pg). The p-value was between 0.05 and 0.10 (about 0.06), indicating a high level of confidence that fell just short of statistical significance. Interestingly, and in contrast to carnosine, use of 1 wt.% cross-linked Hyacross® TL100 had no effect on the topical delivery of arginine, as shown in FIG. 3 (p = 0.71). Although carnosine and arginine are hydrophilic, arginine has a somewhat lower (z.e., more negative) logP than carnosine (-3.5 vs -3.0 respectively), which would indicate more difficulty in arginine penetrating into the skin. Therefore, without wishing to be bound by theory, it is believed that a larger ratio of crosslinked hyaluronic acid to active ingredient may be desirable for cross-linked hyaluronic acid to boost the topical delivery of arginine in comparison to carnosine.Example 2 - Comparison of High Molecular Weight and Cross-linked Hyaluronic Acid

[0097] To further probe the ability of cross-linked hyaluronic acid as an agent to boost topical delivery of an active ingredient, experiments with arginine were conducted in a similar manner to those described above in Example 1, but with a linear, high molecular weight hyaluronic acid instead of cross-linked hyaluronic acid. The linear, high molecular weight hyaluronic acid used was HyBloom® (Bloomage Biotechnology Corp. Ltd), which has a molecular weight of about 1.0- 1.8 MDa. In the first study, 1 wt.% HyBloom® was directly incorporated into the Basecomposition as disclosed in Example 1 together with 2 wt.% arginine, and the results are shown in FIG. 4. In the second study, 1 wt.% HyBloom® was first dissolved in water, and 3 wt.% of this aqueous solution was then incorporated into the base composition together with 2 wt.% arginine to replicate the use of the cross-linked hyaluronic acid material. The results of this second study are shown in FIG. 5. In both the first and second study, the use of high molecular weight linear hyaluronic acid did not result in increased delivery of arginine. Even though high molecular weight hyaluronic acid still has a strong propensity to bind to water, the results indicated that cross-linked hyaluronic acid is unique in its particularly high water binding capacity, as well as its concurrent ability to hydrate the upper layers of the skin.Example 3 - Cross-linked Hyaluronic Acid and Delivery of Vitamin E

[0098] Next, the dermal delivery of alpha-tocopherol (vitamin E) using cross-linked hyaluronic acid was assessed. To the base composition prepared in Example 1 was added 0.5 wt.% tocopherol to prepare a first composition (Composition E). A second composition, Composition F, was prepared by adding to the base composition prepared in Example 1 0.5 wt.% tocopherol and 1 wt.% Hyacross® TL100 (i.e., 0.01 wt.% - 0.05 wt.% cross-linked hyaluronic acid).

[0099] The dermal delivery of each composition was assessed through tape strips. To assess the dermal delivery, skin penetration studies were conducted for 24 hours on a DHC-6T Franz cell unit from Logan Technologies (Somerset, NJ). Briefly, the skin samples were prepared by first tape stripping the top three layers. With the remainder of the skin, the epidermis and dermis were separated by briefly heating in PBS buffer. The dermis and epidermis layers were then each homogenized in methanol. Analyte from the tape strip region was extracted in methanol, and the level of alpha-tocopherol in each of the three regions (tape strips, epidermis, and dermis) was measured. The level of alpha- tocopherol was measured using an Agilent 1200 or Agilent 1260 HPLC unit equipped with a UV-Vis detector, and tocopherol content was detected.

[0100] The results are shown in FIG. 6. As shown, in contrast to carnosine or arginine, the incorporation of cross-linked hyaluronic acid in Composition F did not lead to an increase in the level of alpha-tocopherol delivered into the skin as compared to Composition E. Table 3 below shows the results as graphically illustrated in FIG. 6.

[0101] Table 3 -Delivery of Tocopherol

[0102] As disclosed herein, while not wishing to be bound by theory, the proposed delivery benefits provided by cross-linked hyaluronic acid are thought to be derived from its unique ability to hydrate the upper layers of the skin. Given this mode of action, the active ingredients that are believed to mostly likely benefit from incorporation of hyaluronic acid will be hydrophilic active ingredients, such as arginine and carnosine, rather than a hydrophobic active ingredient such as alpha-tocopherol, which will have little affinity for a water-rich environment.Example 4 - Cross-linked Hyaluronic acid and Delivery of Sodium and Zinc PCA

[0103] Next, it was explored whether the enhanced penetration effects of cross-linked hyaluronic acid could be observed with sodium pyroglutamate (PCA) and zinc PCA. Sodium PCA is already present in the skin as part of the natural moisturizing factor (NMF), and thus many skincare products incorporate it as a topical active. Zinc PCA is similar, although the replacement of sodium with zinc may provide additional beneficial skin properties.

[0104] Four compositions were prepared as follows. A first composition was prepared by adding to the base composition described in Example 1 2 wt.% sodium PCA, and a second composition was prepared by adding to the base composition described in Example 1 2 wt.% sodium PCA and 2 wt.% Hyacross® TL100. A third composition was prepared by adding to the base composition described in Example 1 2 wt.% zinc PCA, and a fourth composition was prepared by adding to the base composition described in Example 1 2 wt.% zinc PCA and 2 wt.% Hyacross® TL100.

[0105] Dermal delivery was assessed as disclosed above. Namely, skin penetration studies were conducted for 24 hours on a DHC-6T Franz cell unit from Logan Technologies (Somerset, NJ). Active content in the skin was measured using an Agilent 1200 or Agilent 1260 HPLC unit equipped with a UV-Vis detector. Both sodium PCA and zinc PCA all required derivatization as they possess minimal inherent UV absorption.

[0106] The results are shown in FIG. 7 for sodium PCA and in FIG. 8 for zinc PCA.

[0107] Interestingly, although the use of crosslinked hyaluronic acid increased the topical delivery of sodium PCA, it did not increase the topical delivery of zinc PCA. It is noted that it is the PCA anion itself that is measured by the HPLC method, and not the counterion. Despite that, the choice of counterion appears to play a role in delivery. Sodium is an alkali metal, and as such it has a single positive charge in its cationic state. In contrast, zinc is a transition metal present in its +21096876-00-WQ-01-SH oxidation state in zinc PCA. While not wishing to be bound by theory, it is believed that the zinc present in zinc PCA can potentially bind to multiple anionic / water binding sites of the cross-linked hyaluronic acid present, hindering its ability to hydrate the outer layers of the skin. Such an effect is not observed with sodium; therefore cross-linked hyaluronic acid boosts the topical delivery of sodium PCA but not zinc PCA.Example 5 - Cross-linked Hyaluronic acid and Delivery of Medium Molecular Weight Hyaluronic Acid

[0108] The active ingredients described in Example 1-4 above (carnosine, arginine, tocopherol, sodium PCA, and zinc PCA) are small molecules that can be detected via HPLC. In contrast, the present example investigates the penetration boosting properties of cross-linked hyaluronic acid by assessing whether it can boost the topical delivery of a relevant, hydrophilic macromolecule. One such target active ingredient is (linear) hyaluronic acid itself. Linear hyaluronic acid, in particular low and / or medium molecular weight hyaluronic acid, may be present in premium skincare products, where its smaller molecular weight may allow it to penetrate into the skin with some degree of ease, especially when compared to high molecular weight and / or cross-linked hyaluronic acid. Therefore, for this example, it was investigated whether cross-linked hyaluronic acid can boost the dermal delivery of topically-applied medium molecular weight hyaluronic acid.

[0109] MALDLMSI was run on frozen human skin obtained from GenoSkin. The MALDLMSI was performed using 7T-MALDI-FTICR imaging at 60 pm spatial resolution. Samples were sectioned using a cryostat, and the hyaluronic acid in the skin was digested using a hyaluronidase enzyme (enzyme Hl 136 from Sigma Aldrich), to yield low molecular weight hyaluronic acid fragments. MALDLMSI was analyzed with Fleximaging v5.0, Data Analysis v5.0, and Multimaging vl.2.

[0110] For this example, Hyacross® TL100 material was used for the cross-linked hyaluronic acid. The medium molecular weight hyaluronic acid was HA-TLM 20-40, a hyaluronic acid material from Bloomage with a molecular weight between 200-400 kDa, wherein the average molecular weight for the lot in this example was about 370 kDa. Medium molecular weight hyaluronic acid was chosen due to the concerns of using either low or high molecular weight hyaluronic acid. Eow molecular weight hyaluronic acid was thought to penetrate into the skin too readily, and therefore may not be impacted by the presence of cross-linked hyaluronic acid. Incontrast, high molecular weight hyaluronic acid is believed to be too large to penetrate into the skin under any circumstance, with or without cross-linked hyaluronic acid.

[0111] The frozen human skin samples were treated with either (1) the base composition described above in Example 1 (Control), (2) the base composition with 1 wt.% Hybloom® medium molecular weight hyaluronic acid (Formulation 1), or (3) the base composition with 1 wt.% Hybloom® medium molecular weight hyaluronic acid and 3 wt.% Hyacross® TL100 (Formulation 2).

[0112] The hyaluronic acid distribution in the skin for the samples treated samples was imaged and measured, and a graph showing the distribution of hyaluronic acid in the three sets of samples is provided in FIG. 9. FIG. 9 is a graph showing the intensity of the hyaluronic acid based on the depth from the skin surface. The introduction of 1 wt.% Hybloom® medium molecular weight hyaluronic acid (Formulation 1) caused a near uniform increase in hyaluronic acid throughout the skin as compared to the Control, indicating that this molecular weight can penetrate the skin to some extent. With the addition of 3 wt.% Hyacross® cross-linked hyaluronic acid, there was an even further increase throughout the skin, confirming the trend shown above with the smaller molecules.Example 6 - Cross-linked Hyaluronic Acid Absent Additional Active Ingredients

[0113] It was further sought to investigate was what specifically was causing the increase in hyaluronic acid penetration observed in Example 5 above. Although presumably the inclusion of cross-linked hyaluronic acid caused more of the medium molecular weight hyaluronic acid to penetrate into the skin, it initially could not be ruled out that at least some of the increase in hyaluronic acid signal was caused by the cross-linked hyaluronic acid itself penetrating into the skin. In particular, the use of hyaluronidase to degrade the hyaluronic acid means that it may be difficult to discern between the medium molecular weight hyaluronic acid and cross-linked hyaluronic acid (or any other molecular weight of hyaluronic acid). Although in practice substantial dermal delivery of cross-linked hyaluronic acid seems unlikely, to fully rule out this possibility, skin samples that were treated with the base composition only (Control) or the base composition plus 3 wt.% cross-linked hyaluronic acid were tested.

[0114] The hyaluronic acid signal for skin samples treated with the base Control and the base + 3% cross-linked hyaluronic acid was measured using the MALDI-MSI procedure as disclosed in Example 5. Based on the results of the MALDI-MSI images, a distribution graph of the hyaluronicacid in the skin of the two different sets of samples is shown in FIG. 10. As shown in FTG. 10, there was no discernible difference in the hyaluronic acid level in skin samples treated with base only or with base + 3 wt.% cross-linked hyaluronic acid material. Therefore, the results indicate that the effects of increased hyaluronic acid observed in Example 5 above was due to an increase in hyaluronic acid originating from the medium weight hyaluronic acid, and not from any crosslinked hyaluronic acid that may have penetrated into the skin.

[0115] In summary, the Examples show that cross-linked hyaluronic acid boosted the topical delivery of a variety of relevant skincare active ingredients into the skin. In particular, cross-linked hyaluronic acid boosted the topical delivery of hydrophilic active ingredients, including the hydrophilic amino acids carnosine and arginine, but not hydrophobic tocopherol (vitamin E). Cross-linked hyaluronic was also shown to boost the topical delivery of sodium PCA and medium weight hyaluronic acid. Additionally, this effect was limited to cross-linked hyaluronic acid, and was not exhibited by high molecular weight linear hyaluronic acid, indicating a mode of action that centers on the unique ability of cross-linked hyaluronic acid to form a network-like structure on the skin surface.

Claims

CLAIMSWhat Is Claimed Is:

1. A personal care composition for delivering at least one hydrophilic active ingredient into skin, comprising: at least one cross-linked hyaluronic acid; and the at least one hydrophilic active ingredient.

2. The personal care composition according to claim 1, wherein the at least one cross-linked hyaluronic acid is present in the personal care composition in an amount ranging from about 0.001 wt.% to about 0.5 wt.%. by weight based on a total weight of the personal care composition.

3. The personal care composition according to claim 1 or claim 2, wherein the at least one hydrophilic active ingredient is selected from amino acids, peptides, vitamins, humectants, and linear hyaluronic acid.

4. The personal care composition according to claim 3, wherein the at least hydrophilic active ingredient is an amino acid selected from arginine.

5. The personal care composition according to claim 3 or 4, wherein the at least one hydrophilic active ingredient is a peptide selected from camosine.

6. The personal care composition according to any one of claims 3-5, wherein the at least one hydrophilic active ingredient is a humectant selected from sodium pyroglutamate.

7. The personal care composition according to any one of claims 3-6, wherein the linear hyaluronic acid is selected from medium molecular weight linear hyaluronic acid and low molecular weight linear hyaluronic acid.

8. The personal care composition according to any one of claims 3-7, wherein the linear hyaluronic acid is a low molecular weight linear hyaluronic acid having a molecular weight of up to 50,000 Da.

9. The personal care composition according to any one of claims 1-7, wherein the linear hyaluronic acid is a medium molecular weight linear hyaluronic acid having a molecular weight of greater than 50,000 to 400,000 Da.

10. The personal care composition according to claim 1, wherein the at least one active ingredient consists of a medium molecular weight linear hyaluronic acid or low molecular weight linear hyaluronic acid, preferably a medium molecular weight linear hyaluronic acid.

11. The personal care composition according to any one of the preceding claims, wherein the personal care composition further comprises at least one additional active ingredient, optionally a hydrophobic active ingredient.

12. The personal care composition according to any one of the preceding claims, wherein the at least one hydrophilic active ingredient is present in an amount ranging from about 0.01 wt.% to about 5 wt.%, such as from about 0.01 wt.% to about 0.5 wt.% or from about 1 wt.% to about 3 wt.%, by weight based on a total weight of the personal care composition.

13. The personal care composition according to any one of the preceding claims, wherein the at least one cross-linked hyaluronic acid is an elastomer.

14. The personal care composition according to any one of the preceding claims, wherein the at least one cross-linked hyaluronic acid is present in an amount ranging from about 0.001 wt.% to about 1 wt.%, such as from about 0.01 wt.% to about 0.5 wt.% or from about 0.01 wt.% to about 0.15 wt.%, by weight based on a total weight of the personal care composition.

15. The personal care composition according to any one of the preceding claims, wherein the personal care composition is for topical use suitable for application to the skin.

16. The personal care composition according to any one of the preceding claims, wherein the personal care composition is a leave-on skin care composition, optionally a cream, lotion, or serum.

17. A method of delivering of at least one active ingredient into skin of a subject, the method comprising applying the personal care composition according to any one of claims 1-16 to the skin of the subject, wherein the method enhances delivery of the at least one active ingredient as compared to a personal care composition that does not comprise at least one cross-linked hyaluronic acid.

18. The method according to claim 17, wherein the personal care composition is applied topically.

19. The method according to claim 17 or 18, wherein the method enhances delivery of the at least one active ingredient as compared to a personal care composition that does not comprise at least one cross-linked hyaluronic acid by an amount of at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, or at least about 35%.

20. The method according to any one of claims 17-19, wherein the personal care composition is applied in an amount ranging from about 5 to about 100 mg / in2of skin, optionally in an amount ranging from about 20 to about 50 mg / in2; about 25 to about 45 mg / in2, or about 30 to about 35 mg / in2.

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