Gut microbiome psychobiotics, extracellular vesicles therefrom, compositions comprising the same and methods of using same

Psychobiotic compositions derived from Bacteroides, Lactobacillus, and Bifidobacterium strains provide neuroactive compounds to treat psychiatric disorders and improve gut health by leveraging the gut-brain axis and immune modulation, addressing the lack of effective interventions in current therapies.

WO2026123112A1 Publication Date: 2026-06-18UNIVERSITY OF OTTAWA
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
UNIVERSITY OF OTTAWA
Filing Date
2025-12-10
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Current therapies for psychiatric disorders, gut health, and inflammation lack effective interventions that leverage the gut microbiome's neuroactive compounds, particularly GABA and serotonin, to modulate brain function and immune responses.

⚗Method used

Development of psychobiotic compositions comprising Bacteroides, Lactobacillus, and Bifidobacterium strains and their extracellular vesicles, which produce and deliver neuroactive compounds like GABA and 5-hydroxytryptophan, formulated as therapeutic, food, or feed additives to treat psychiatric disorders, improve gut health, and reduce inflammation.

🎯Benefits of technology

The compositions effectively treat psychiatric disorders such as schizophrenia, autism, anxiety, and depression, improve gut health, and reduce both gut and systemic inflammation by utilizing the gut-brain axis signaling and immune modulation.

✦ Generated by Eureka AI based on patent content.

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Abstract

There is provided gut microbiome psychobiotics, extracellular vesicles, compositions comprising the same and methods of using same. More particularly, there is provided Bacteroides, Lactobacillus and Bifidobacterium psychobiotics and extracellular vesicles therefrom. The methods include methods of treating and / or preventing a psychiatric disorder, methods of improving gut health and methods of reducing inflammation. Also provided are compositions including compositions comprising the psychobiotics and / or extracellular vesicles.
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