Cells expressing CARs and transcription factors, and their use

Abstract

Providing cells expressing CARs and transcription factors, and the use thereof. [Solution] The present inventors have found that co-expression of a transcription factor and a CAR in cells can prevent or reduce cell differentiation and / or exhaustion. This results in the fact that increasing the proportion of naive cells, central memory cells, and stem cell-like memory cells in a cell composition for immunotherapy leads to more effective persistence and expansion of these cells in vivo. The present invention provides cells comprising a first exogenous nucleic acid molecule encoding a chimeric antigen receptor (CAR) and a second exogenous nucleic acid molecule encoding a transcription factor.

Images