Microbubble generation assembly and device

By designing a fluid-gas mixing structure and a Venturi tube, and utilizing Bernoulli's principle and turbulent shearing, the problem of time-consuming and labor-intensive microbubble generation in existing technologies has been solved. This enables the rapid and efficient generation of small and numerous microbubbles, thereby improving the production efficiency of ultrasound contrast agents.

WO2026124053A1PCT designated stage Publication Date: 2026-06-18SHANGHAI SHAPE MEMORY ALLOY

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
SHANGHAI SHAPE MEMORY ALLOY
Filing Date
2025-11-05
Publication Date
2026-06-18

AI Technical Summary

Technical Problem

In existing technologies, the preparation of ultrasound contrast agents for diagnosing PFO is time-consuming and labor-intensive, with poor mixing effects, making it difficult to quickly and efficiently manufacture small and numerous microbubbles.

Method used

It employs a fluid-gas mixing structure, utilizing Bernoulli's principle to mix gas into the fluid through pressure potential difference when the fluid static pressure decreases, and uses Venturi tubes and turbulent shearing to form small microbubbles.

🎯Benefits of technology

It enables the rapid and efficient generation of numerous small microbubbles, improving the production efficiency of ultrasound contrast agents and reducing the impact of operation time and human factors.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates to a microbubble generation assembly and device. The microbubble generation assembly comprises: a first connector and a second connector. One end of the first connector is provided with a syringe connector, and the other end is provided with a first connecting section connected to the second connector. The first connecting section consists of a first straight section and a first contraction section. The second connector comprises a second connecting section and a Venturi tube, and a gap cavity is provided between the first contraction section and a third contraction section of the Venturi tube. A side wall of the second connecting section is provided with a plurality of air inlet channels connected to the gap cavity. An independent mixing structure of a fluid and a gas is used, utilizing the Bernoulli principle for acceleration to reduce the static pressure of the fluid. In combination with the gap cavity between the first contraction section and the Venturi tube, when the accelerated liquid enters the fluid channel of the second connector, more gas in the gap cavity is brought into the liquid, and bubbles in the liquid can be sheared by means of the Venturi tube structure, such that the volume of the bubbles is reduced and the number of the bubbles is increased.
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Description

A microbubble generation component and device Technical Field

[0001] This invention belongs to the field of medical device technology, specifically relating to a microbubble generating component and a microbubble generating device using the component. Background Technology

[0002] Patent foramen ovale (PFO) is a congenital heart defect in which the foramen ovale between the left and right atria fails to close completely during early childhood development, resulting in an abnormal passage between the two atria. PFO is present in one-quarter of the general population and is associated with various diseases, particularly migraines and cryptogenic stroke.

[0003] Currently, patent foramen ovale (PFO) is typically diagnosed via transthoracic echocardiography or transcranial Doppler ultrasound. Right heart system contrast echocardiography is a widely used ultrasound diagnostic technique for the clinical diagnosis and treatment of PFO, often employing ultrasound contrast agents (microbubbles). These microbubbles are injected intravenously and travel through the bloodstream to the right atrium. In the presence of PFO, these microbubbles can pass through the unclosed foramen ovale into the left atrium, left ventricle, aorta, and intracranial arteries. These microbubbles strongly reflect ultrasound waves, making them detectable by echocardiography or transcranial Doppler ultrasound probes, thus confirming the presence and size of the PFO.

[0004] In existing technologies, the preparation of ultrasound contrast agents for diagnosing PFO mainly relies on manual oscillation, which involves manually injecting saline solution into two syringes connected to a three-way stopcock 15-20 times to ensure thorough mixing of the saline solution and gas. This method has the following drawbacks: First, it is time-consuming and labor-intensive. Each patient typically requires three contrast examinations, and the preparation of each examination takes at least 3-5 minutes. If multiple patients are examined consecutively, it can take tens of minutes to prepare the contrast agent. Second, inexperienced operators may inject the contrast agent too slowly or with inconsistent injection numbers, resulting in poor mixing. Therefore, there is an urgent need for a microbubble generation structure that produces small-volume, highly efficient microbubbles. Summary of the Invention

[0005] In view of this, the present invention provides a microbubble generating component, which adopts an independent fluid and gas mixing structure and applies this structure into a fluid channel. Utilizing Bernoulli's principle, when the static pressure of the fluid decreases, the pressure potential difference is used to mix more gas into the fluid, thereby achieving the effect of mixing more bubbles into the contrast agent. After the gas and liquid are mixed, they pass through a Venturi tube. In the diffusion section, the gas phase will be squeezed into smaller bubbles due to the increased static pressure. At the same time, the bubble volume will be further reduced by the shearing effect of turbulence, thus achieving rapid bubble generation.

[0006] The technical solution adopted in this invention is as follows:

[0007] A microbubble generating assembly includes: a first connector and a second connector, each having a fluid channel; one end of the first connector is provided with a syringe connector, and the other end is provided with a first connecting segment connected to the second connector, the first connecting segment consisting of a first straight segment and a first constricted segment; the second connector includes an integrally formed second connecting segment and a venturi tube, the first connecting segment being connected to the second connector via the second connecting segment, and a gap cavity being provided between the first constricted segment and a third constricted segment of the venturi tube; a plurality of air inlet channels connected to the gap cavity are provided on the sidewall of the second connecting segment.

[0008] In a further optimization of the technical solution of the present invention, the second connecting section is composed of a second straight section and a second contracting section. The second contracting section is a frustoconical contracting section, and its end inner diameter is smaller than the maximum inner diameter of the third contracting section. The inner diameter of the second straight section is equal to the outer diameter of the first straight section, and the inner diameter of the second contracting section is equal to the outer diameter of the corresponding part of the first contracting section. The gap cavity is composed of the inner diameter of the third contracting section and the outer diameter of the first contracting section.

[0009] In a further optimization of the technical solution of the present invention, a first straight hole is provided at the end of the inner wall of the first contraction section, and the Venturi tube includes a third contraction section, a third straight section and an expansion section. The first straight hole is gap-connected to the third straight section, and the diameter of the first straight hole is smaller than the inner diameter of the third straight section.

[0010] A further optimization of the technical solution of the present invention includes a third connector, which is connected to the side wall of the first connector and the end of the second connector away from the second connecting segment. The third connector is provided with a sterile air chamber connected to the air inlet channel, and the first connector is provided with a first through hole communicating with the sterile air chamber. The outlet of the third connector is also provided with a needle connector for connecting an injection needle.

[0011] In a further optimization of the technical solution of the present invention, a first stepped groove is provided on the inner wall of one end of the third connector, a sealing platform is provided on the first connector to cooperate with the first stepped groove, a sealing groove for placing an O-ring is provided on the sealing platform, and the first through hole is opened between the sealing platform and the first connector.

[0012] In a further optimization of the technical solution of the present invention, an annular platform is provided between the through hole and the first connecting section, and the annular platform divides the sterile air chamber into a first air chamber and a second air chamber that are connected. The first through hole is directly connected to the first air chamber. The gap cavity is connected to the second air chamber through the air inlet channel, and the connection between the first air chamber and the second air chamber is far away from the air inlet channel.

[0013] In a further optimization of the technical solution of the present invention, the second connecting body further includes a third connecting section, which is connected to the expansion section of the venturi tube, and the outer sidewall of the third connecting section is a tapered sidewall. The third connecting body is provided with a second stepped groove that matches the third connecting section, and the second stepped groove is sealed to the third connecting section.

[0014] A further optimization of the technical solution of the present invention is that a second through hole is provided on the fluid channel of the third connecting segment or the third connecting body.

[0015] In a further optimization of the technical solution of the present invention, a plurality of Venturi structures are provided on the fluid channel between the second stepped groove and the connector, and a second through hole is provided on the throat of the Venturi structure and / or on the flat DC body channel connected to the expansion section.

[0016] A further optimization of the technical solution of the present invention is that a microporous structure for cutting bubbles is provided on the fluid channel downstream of the venturi tube.

[0017] The present invention also provides a microbubble generating device, comprising: a syringe, an injection needle, and the microbubble generating component described above, wherein the syringe is connected to the first connector, and the injection needle is connected to the end of the second connector or a third connector.

[0018] The beneficial effects of this invention are:

[0019] By setting a first contraction section on the first connecting body, the liquid in the fluid channel can be accelerated during injection using Bernoulli's principle, thereby reducing the static pressure of the fluid. In addition, with the gap cavity between the first contraction section and the Venturi tube, when the accelerated liquid enters the fluid channel of the second connecting body, more gas in the gap cavity is brought into the liquid. Furthermore, through the recompression and diffusion of the Venturi tube, the bubbles in the liquid can be sheared, making the volume of the bubbles smaller and the number of bubbles increased, thus producing a liquid that meets the requirements of having a large number of microbubbles and a small volume.

[0020] By setting a third connector and opening a first through hole on the first connector, and combining it with a sterile air chamber, when the component is working, some of the liquid in the fluid channel enters the sterile air chamber through the first through hole, thereby increasing the air pressure in the sterile air chamber. By utilizing the pressure potential difference, the liquid flowing through the fluid channel is mixed with more gas through the gap cavity, increasing the amount of gas mixed in and causing more and smaller microbubbles to be generated in the liquid. Attached Figure Description

[0021] The above and other objects, features and advantages of the present invention will become clearer from the following description of embodiments of the invention with reference to the accompanying drawings, in which:

[0022] Figure 1 is a schematic diagram of the structure of the first connector of the present invention;

[0023] Figure 2 is a cross-sectional view of the first connector of the present invention;

[0024] Figure 3 is a structural schematic diagram of the second connector A and B of the present invention from two perspectives.

[0025] Figure 4 is a cross-sectional view of the second connector of the present invention;

[0026] Figure 5 is a structural schematic diagram of the third connector of the present invention;

[0027] Figure 6 is a cross-sectional structural diagram of the third connector of the present invention;

[0028] Figure 7 is a schematic cross-sectional view of the microbubble generating component of the present invention.

[0029] Figure 8 is a partially enlarged structural diagram of position 1-2 in Figure 7;

[0030] Figure 9 is a schematic cross-sectional view of a preferred embodiment of the microbubble generating component of the present invention.

[0031] In the diagram: 1. First connector; 2. Second connector; 3. Third connector; 5. Fluid channel; 6. Venturi structure;

[0032] 11. Syringe connector; 12. First connecting section; 121. First straight section; 122. First contraction section; 123. First straight hole; 13. Gap cavity; 15. Annular platform; 16. Sealing platform; 17. Sealing groove; 18. First through hole;

[0033] 21. Second connecting section; 211. Second straight section; 212. Second contraction section; 22. Third connecting section; 23. Third contraction section; 24. Third straight section; 25. Expansion section; 26. Intake passage;

[0034] 31. Needle connector; 32. First step groove; 33. Second step groove; 34. Sterile air chamber; 341. First air chamber; 342. Second air chamber. Detailed Implementation

[0035] The present invention is described below based on embodiments, but the present invention is not limited to these embodiments. In the following detailed description of the present invention, some specific details are described in detail, but well-known methods, processes, procedures, and elements are not described in detail in order to avoid obscuring the essence of the present invention.

[0036] Furthermore, those skilled in the art should understand that the accompanying drawings provided herein are for illustrative purposes only and are not necessarily drawn to scale.

[0037] Unless the context explicitly requires it, the words "comprising," "including," and similar terms throughout the specification and claims should be interpreted as encompassing rather than being exclusive or exhaustive; that is, meaning "including but not limited to."

[0038] In the description of this invention, it should be understood that the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Furthermore, in the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0039] Referring to Figures 1-9, the present invention provides a microbubble generating component, including: a first connector 1 and a second connector 2 respectively having fluid channels 5; as shown in Figures 1 and 2, one end of the first connector 1 is provided with a syringe connector 11, and liquid can be injected into the fluid channel 5 connecting the first connector 1 and the second connector 2 through a syringe during use. The other end of the first connector 1 is provided with a first connecting section 12 that connects to the second connector 2. The first connecting section 12 consists of a first straight section 121 and a first contracting section 122. The first contracting section 122 is a tapered structure with a gradually decreasing inner diameter. The aperture of the cone tip is preferably 0.3-0.35 mm. The liquid entering the initial fluid channel 5 can be accelerated through this contracting section, reducing the static pressure in the fluid. Then, the accelerated liquid is transported into the second connector 2. As shown in Figures 3 and 4, the second connector 2 includes an integrally formed second connecting section 21 and a Venturi tube. The first connecting section 12 is connected to the second connector 2 through the second connecting section 21, increasing the stability of the microbubble generating component. The first contracting section 122 cooperates with the third contracting section 23 of the Venturi tube. The taper of the first contracting section 122 and the third contracting section 23 is not strictly required, but is preferably 60 degrees. A gap cavity 13 is provided between the outer wall of the first contraction section 122 and the inner wall of the third contraction section 23. Several air inlet channels 26 connected to the gap cavity 13 are provided on the side wall of the second connecting section 21. Preferably, the width of the air inlet channels 26 is 1-3 mm, mainly used to continuously supply gas to the gap cavity 13. When the liquid flows from the first connecting body 1 to the second connecting body 2, the gas in the gap cavity 13 can be carried into the liquid and enter the Venturi tube. When the fluid flows through the first contraction section 122 and enters the third straight section 24 of the Venturi tube, the flow velocity increases and the static pressure decreases. Then, when it flows into the expansion section 25 of the Venturi tube for diffusion, the flow velocity decreases and the static pressure increases, simultaneously forming turbulence. At this time, the gas phase in the gas-liquid mixture will be compressed into smaller bubbles due to the increased static pressure. Simultaneously, through the shearing action of turbulence, the bubble volume will further decrease, forming a large number of microbubbles. The expansion section 25 of the Venturi tube has a conical diffusion shape, with a preferred taper of 15-50 degrees.

[0040] In this technical solution, the second connecting section consists of a second straight section 211 and a second contracting section 212. The second contracting section 212 is a frustum-shaped contracting section, extending from the large end face to the small end face. The inner diameter of its small end face is smaller than the inner diameter of the large end face of the third contracting section 23, creating a step between the second contracting section 212 and the third contracting section 23. The inner diameter of the second straight section 211 is equal to the outer diameter of the first straight section 121, making the connection between the first connecting body 1 and the second connecting body 2 more stable. The inner diameter of the second contracting section 212 is equal to the outer diameter of the corresponding part of the first contracting section 122. Since the length of the frustum of the second contracting section 212 is less than the length of the cone of the first contracting section 122, the first contracting section 122 passes through the second contracting section 212 and enters the third contracting section 23, thus forming the gap cavity 13 between the outer surface of the first contracting section 122 and the inner surface of the third contracting section 23. See Figure 8 for a more detailed description.

[0041] To increase fluid stability, a first straight hole 123 is provided at the end of the inner wall of the first contraction section 122. The length of the first straight hole 123 is preferably 0.5-1.5 mm, and the diameter is 0.3-0.35 mm. It should be noted that the outer wall of the first contraction section 122 does not have a straight section; instead, it is a conical surface. The first straight hole 123 is gap-connected to the third straight section 24, and the diameter of the first straight hole 123 is smaller than the inner diameter of the third straight section 24. Preferably, the inner diameter of the third straight section 24 is 0.05-0.1 mm larger than the diameter of the first straight hole 123. This improves the smoothness of fluid flow from the first contraction section 122 into the third straight section 24 of the venturi tube. Simultaneously, by utilizing the diffusion effect after the high-speed fluid flow and the pressure difference between the fluid static pressure and the gas in the cavity, more of the liquid phase can mix with the gas phase in the gap cavity 13.

[0042] Based on the above technical solutions, the preferred embodiment of this application further includes a third connector 3 as shown in Figures 5 and 6. The third connector 3 is connected to the side wall of the first connector 1 and the end of the second connector 2 away from the second connecting segment 21. Specifically, the front section of the third connector 3 is a cavity structure, and the inner wall of the free end of the cavity is provided with a first stepped groove 32, as shown in Figure 7. After the first connector 1 and the second connector 2 are connected, they are installed in the cavity of the third connector 3. The first connector 1 is provided with a sealing platform 16 that cooperates with the first stepped groove 32. The cooperation between the first stepped groove 32 and the sealing platform 16 enables a sealed connection between the first connector 1 and the third connector 3. This connection can be a structure with threads and a sealing gasket, or it can be a snap-fit ​​connection. To improve the sealing performance between the first connector 1 and the third connector 3, preferably, the sealing platform 16 is provided with a sealing groove 17 for placing an O-ring. The third connector 3 is provided with a sterile air chamber 34 connected to the air inlet channel 26. Specifically, the sterile chamber is composed of the side wall of the first connecting section 12 and the side wall of the second connector 2, respectively, and the inner wall of the cavity of the third connector 3. The first connector 1 is provided with a first through hole 18 that communicates with the sterile air chamber 34. Preferably, the first through hole 18 is located between the sealing platform 16 and the first connecting section 12. The number of through holes 18 can be one, two, or more, and the diameter of the first through hole 18 is 0.15mm-0.35mm. The other end of the third connector 3 is provided with a needle connector 31 for connecting an injection needle.

[0043] To improve the mixing degree of liquid and gas, an annular platform 15 is provided on the first connector 1 between the through hole and the first connecting section 12. The annular platform 15 divides the sterile air chamber 34 into a first air chamber 341 and a second air chamber 342 that are connected. The first through hole 18 is directly connected to the first air chamber 341. The gap cavity 13 is connected to the second air chamber 342 through a gas channel. The connection between the first air chamber 341 and the second air chamber 342 is far away from the air inlet channel. Since the first through hole 18 is located upstream of the gas channel, when the liquid enters the fluid channel 5 under the push of the syringe, under the action of the first contraction section 122, some of the liquid will enter the sterile air chamber 34 through the first through hole 18, thereby increasing the pressure in the sterile air chamber 34 and causing the gas to enter the gap cavity 13 to mix with the liquid. By providing the annular platform 15, the first through hole 18 and the gas channel 26 can be separated. The purpose of keeping the connection between the first air chamber 341 and the second air chamber 342 away from the air inlet channel is to ensure that when the liquid flowing out of the first through hole 18 flows into the second air chamber 342 through the connection, the liquid flowing out of the first through hole 18 does not come into contact with the air inlet of the air inlet channel 26, thus preventing liquid from flowing into the gap cavity and affecting the mixing of gas and liquid. The connection between the first air chamber 341 and the second air chamber 342 can be the gap between the annular platform 15 and the inner wall of the third connector 3, or it can be set as a separate connecting hole. In practical applications, the microbubble generating components are mostly in a vertical state. In this way, the liquid flowing out of the first through hole 18 will enter the bottom of the second air chamber 342 from the first air chamber 341 through the connection under the action of gravity. This will compress the gas in the entire sterile air chamber 34, increasing the pressure, and the air pressure in the gap cavity connected to it will also increase, thus creating a pressure difference between the gap cavity and the fluid, which is conducive to the gas entering the liquid.

[0044] Based on the third connector 3, the second connector 2 further includes a third connecting section 22, which is connected to the expansion section 25 of the Venturi tube. That is, the fluid channel 5 of the Venturi tube expansion section 25 continues to extend to form the third connecting section 22. To facilitate the connection and sealing between the third connecting section 22 and the third connector 3, the outer wall of the third connecting section 22 is a tapered sidewall. The third connector 3 is provided with a second stepped groove 33 that matches the third connecting section 22. The inner wall of the second stepped groove 33 also has an inclination corresponding to that of the third connecting section 22, thus facilitating a sealed connection between the second stepped groove 33 and the third connecting section 22. Preferably, the third connector 3 includes a tubular outer shell connected to the first connector 1 and the second connector 2. Inside the outer shell, a third mounting post is provided, connected to the second connector 2. One end of the third mounting post is adjacent to the needle connector 31 of the injection needle, and the other end has a second stepped groove 33 on the fluid channel 5. A gap is left between the side wall of the third mounting post and the shell, forming part of the second air chamber 342. The cover design mainly facilitates the connection between the second connector 2 and the third connector 3. Alternatively, the third connecting section 22 and the third mounting post can be connected by a threaded seal or by a snap-fit ​​with a sealing ring.

[0045] In a preferred embodiment of this technical solution, in order to better mix more gas into the liquid in the fluid channel 5, a second through hole is provided on the third connecting section 22 or the fluid channel 5 of the third connecting body 3. The second through hole is connected to the second gas chamber 342. During operation, the gas in the second gas chamber 342 can also enter the fluid channel 5 through the second through hole to mix with the flowing liquid, thereby increasing the amount of gas mixed in the liquid phase. Preferably, the diameter of the second through hole is between 0.1 mm and 0.2 mm.

[0046] Another preferred embodiment of this technical solution, as shown in Figure 9, involves a plurality of Venturi structures 6 disposed on the fluid channel 5 between the second stepped groove 33 and the connector. The taper of the contraction section and expansion section 25 of all Venturi structures 6 can be kept consistent, but the diameter of the throat increases sequentially from upstream to downstream. Preferably, the throat diameters of two adjacent Venturi structures 6 differ by 0.05mm-0.1mm. Through the contraction section, the straight throat section, and the expansion section 25 of the Venturi structure 6, the mixture of gas and liquid phases can be compressed and turbulently sheared, making the gas phase in the liquid phase smaller. Furthermore, a second through hole is provided on the throat of the Venturi structure 6 and / or on the straight fluid channel 5 connected to the expansion section 25. The second through hole is connected to the sterile air chamber 34. This allows more gas phase to be mixed into the liquid phase in the fluid channel 5 during operation. In conjunction with the working principle of the Venturi structure, the gas phase can be cut into more and smaller microbubbles. The working principle of the second through hole is the same as that of the first through hole 18.

[0047] To increase the number of bubbles while reducing their volume, preferably, the fluid channel 5 downstream of the venturi tube is provided with a microporous structure for breaking up the bubbles. This microporous structure is not limited to woven mesh, perforated membrane, or other loose porous structures; preferably, the micropore diameter is between 1 and 15 micrometers. Bubbles in the gas-liquid mixture are further broken up as they flow through the microporous structure, forming even smaller microbubbles. Of course, the pore size of the microporous structure can be adjusted and selected according to the final required bubble size.

[0048] This invention also provides a microbubble generating device, comprising: a syringe, an injection needle, and the microbubble generating component described above. The syringe is connected to the first connector, and the injection needle is connected to the end of the second connector 2 or the third connector 3. Preferably, the injection needle is an 18G, 20G, or 22G needle. In use, simply draw the injection liquid into the syringe, then connect the syringe to the microbubble generating component, and directly push the syringe. The liquid in the syringe will enter the microbubble generating component for gas-liquid mixing. When output through the injection needle, it is a liquid containing a large number of stable microbubbles, which can be directly applied. This improves work efficiency and achieves better imaging results, facilitating diagnosis. In this embodiment, to improve the stability of liquid microbubbles in the fluid, a surfactant can be added to the liquid to reduce the coalescence rate of microbubbles. Surfactants can be polysorbate, propylene glycol, polyethylene glycol, lecithin, poloxamer, glycerin, hypertonic saline, etc.

[0049] For the syringe, a 5ml syringe is preferred (in the prior art, a 10ml syringe is usually used, mixing 9ml of liquid phase and 1ml of gas phase). This is because the design of the microbubble generating component in this technical solution increases the resistance when the fluid flows in the fluid channel, which increases the resistance for the operator to press the syringe and increases the operator's burden. By using a 5ml syringe, the amount of fluid injected per unit time can be reduced at the same syringe pushing speed, thereby reducing the resistance to pushing the syringe and improving the operator's use effect. At the same time, because the microbubble generating component in the above technical solution has high foaming efficiency, it can also mix nearly 1ml of gas into the 5ml liquid phase.

[0050] It should be understood that the above embodiments are merely exemplary and not restrictive. Various obvious or equivalent modifications or substitutions that can be made by those skilled in the art regarding the above details without departing from the basic principles of the present invention will be included within the scope of the claims of the present invention.

Claims

1. A microbubble generating component, characterized in that, include: A first connector and a second connector, each having a fluid channel; One end of the first connector is provided with a syringe connector head, and the other end is provided with a first connecting segment that connects to the second connector. The first connecting segment is composed of a first straight segment and a first contracting segment. The second connector includes an integrally formed second connecting section and a venturi tube. The first connecting section is connected to the second connector through the second connecting section, and a gap cavity is provided between the first contraction section and the third contraction section of the venturi tube. The second connecting section has several air intake channels on its side wall that are connected to the gap cavity.

2. The microbubble generating component according to claim 1, characterized in that, The second connecting section consists of a second straight section and a second contracting section. The second contracting section is a frustoconical contracting section, and its end inner diameter is smaller than the maximum inner diameter of the third contracting section. The inner diameter of the second straight section is equal to the outer diameter of the first straight section. The inner diameter of the second contracting section is equal to the outer diameter of the corresponding part of the first contracting section. The gap cavity is composed of the inner diameter of the third contracting section and the outer diameter of the first contracting section.

3. The microbubble generating component according to claim 1, characterized in that, The inner wall end of the first contraction section is provided with a first straight hole. The venturi tube includes a third contraction section, a third straight section and an expansion section. The first straight hole is connected to the third straight section with a gap, and the diameter of the first straight hole is smaller than the inner diameter of the third straight section.

4. The microbubble generating component according to any one of claims 1-3, characterized in that, It also includes a third connector, which is connected to the side wall of the first connector and the end of the second connector away from the second connecting section. The third connector is provided with a sterile air chamber connected to the air inlet channel, and the first connector is provided with a first through hole connected to the sterile air chamber. The outlet of the third connector is also provided with a needle connector for connecting an injection needle.

5. The microbubble generating component according to claim 4, characterized in that, The inner wall of one end of the third connector is provided with a first stepped groove, and the first connector is provided with a sealing platform that cooperates with the first stepped groove. The sealing platform is provided with a sealing groove for placing an O-ring, and the first through hole is opened between the sealing platform and the first connector.

6. The microbubble generating component according to claim 5, characterized in that, An annular platform is provided between the through hole and the first connecting section, and the annular platform divides the sterile air chamber into a first air chamber and a second air chamber that are connected. The first through hole is directly connected to the first air chamber. The gap cavity is connected to the second air chamber through the air inlet channel, and the connection between the first air chamber and the second air chamber is far away from the air inlet channel.

7. The microbubble generating component according to claim 4, characterized in that, The second connector further includes a third connecting section, which is connected to the expansion section of the venturi tube. The outer sidewall of the third connecting section is a tapered sidewall. The third connector is provided with a second stepped groove that matches the third connecting section. The second stepped groove is sealed to the third connecting section.

8. The microbubble generating component according to claim 7, characterized in that, The fluid channel between the second stepped groove and the connector is provided with a plurality of venturi structures, and a second through hole is provided in the throat of the venturi structure and / or in the flat DC body channel connected to the expansion section.

9. The microbubble generating component according to any one of claims 1-3 or 5-8, characterized in that, The fluid channel downstream of the venturi tube is provided with a microporous structure for cutting up air bubbles.

10. A microbubble generating device, characterized in that, include: The syringe, the injection needle, and the microbubble generating component according to any one of claims 1-9, wherein the syringe is connected to the first connector, and the injection needle is connected to the end of the second connector or the third connector.