Cosmetic hydrodispersions containing alkylamidothiazoles

Abstract

The present invention relates to cosmetic hydrodispersions containing alkylamidothiazoles.

Description

[0001] Beiersdorf Aktiengesellschaft Hamburg

[0002] Cosmetic hydrodispersions containing alkylamidothiazoles

[0003] The present invention relates to cosmetic hydrodispersions containing alkylamidothiazoles.

[0004] A person's outward appearance can be influenced and enhanced through the use of cosmetic products. Regular use of cleansing and care products ensures that people feel attractive, beautiful, and comfortable in their surroundings, and radiate this outwards.

[0005] People use cosmetic care products for various reasons. One problem customers want to address is unwanted skin pigmentation, which is caused by melanocytes. These pigment-producing cells are located in the stratum basale, the lowest layer of the epidermis, and appear individually or in greater or lesser numbers, depending on skin type.

[0006] Melanocytes can produce the pigment melanin via their melanosomes. Melanin production can be stimulated by UV radiation, among other factors. Melanin is the product of an oxidative process. Here, tyrosine is converted by the enzyme tyrosinase, through various intermediate steps, into the brown to brownish-black eumelanins (DHICA and DHI melanin), or, when sulfur-containing compounds are involved, into the reddish pheomelanin. The melanin produced is then transported into the stratum corneum (corneocytes) of the epidermis, thus giving the skin its brownish to brownish-black color.

[0007] The two eumelanins, DHICA- and DHI-melanin, share the two intermediates donaquinone and donachrome. These two intermediates are also important in the formation of pheomelanin. The expression of melanin-synthesized enzymes is fundamentally controlled by a specific transcription factor (microphthalmia-associated transcription factor, MITF). In addition to the described enzymatic processes of melanin synthesis, other proteins are also important for melagnosis. The p-protein, among others, is thought to play a significant role, although its exact function is not yet fully understood. Besides melanin synthesis, the transfer of melanosomes, their retention in the epidermis, their degradation, and the breakdown of melanin are also crucial for skin pigmentation. The PAR-2 ​​receptor has been shown to play a fundamental role in the transport of melanosomes into keratinocytes (M. Seiberg et al., 2000, J. Cell. Sei)., 113:3093-101). Nevertheless, the appearance of the skin is also influenced by the size and shape of the individual melanosomes, as these affect light scattering. Accordingly, the skin of Black Africans exhibits more large, spheroidal, and solitary melanosomes, while Caucasians tend to have smaller melanosomes occurring in groups.

[0008] Hyperpigmentation of the skin can have various causes. It can occur as a side effect of many biological processes, such as UV radiation (e.g., freckles, ephelides), abnormal pigmentation of the skin during wound healing or scarring (post-inflammatory hyperpigmentation), or during skin aging (e.g., lentigines seniles).

[0009] Particularly after inflammatory reactions, the skin's pigmentation system can react with hyper- or hypopigmentation. These reactions frequently occur, for example, in atopic dermatitis, lupus erythematosus, and psoriasis. The appearance of dark circles under the eyes can also be considered a post-inflammatory hyperpigmentation. In these cases, however, the underlying inflammation is usually subclinical. Many hyperpigmentation reactions can be exacerbated by exposure to UV radiation.

[0010] To counteract hyperpigmentation, active ingredients and preparations are known that are essentially based on hydroquinone. However, these formulations and preparations are highly controversial because they can potentially cause irreversible changes to the skin's pigmentation system.

[0011] Furthermore, there are known skin-peeling methods, which, however, can lead to inflammation. This, in turn, can result in post-inflammatory hyperpigmentation.

[0012] Furthermore, other substances for skin lightening have already been described. These include, among others...

[0013] A. to mention: Hexadecen-1,16-dicarboxylic acid, Kojic acid, arbutin, ascorbic acid and their derivatives, flavonoids and various resorcinol derivatives, such as 4-n-butylresorcinol, 4-n-heylresorcinol and 4-(1-phenylethyl)benzen-1,3-diol.

[0014] In a publication (Bioorganic & Medicinal Chemistry Letter 17 (2007) 6871-6875), JM Ready describes the effect of substituted thiazole derivatives on the inhibition of mushroom tyrosinase. Furthermore, substituted thiazolamines and hydrothiazolamines are described for skin lightening in publication WO 2009099195.

[0015] The substances described in the above-mentioned state of the art are characterized by moderate effectiveness.

[0016] Many skincare products are typically made from emulsions. This term refers to heterogeneous systems composed of two liquids that are either immiscible or only partially miscible. One of the two liquids is dispersed in the other liquid as tiny droplets. From the outside, an emulsion appears homogeneous.

[0017] Stabilizing emulsions plays a crucial role in cosmetics, as it prevents the separation and demixing of one of the two phases and ensures a long-lasting product. For this reason, emulsions are formulated with an emulsifier. Emulsifiers are typically molecules with one polar, hydrophilic structural element and one nonpolar, lipophilic structural element. These structural properties enable emulsifiers to stabilize the two-phase systems.

[0018] Besides the classic emulsion, those skilled in the art are also familiar with so-called hydrodispersions, which consist of an outer aqueous phase and a liquid, semi-solid, or solid inner lipid phase. In contrast to classic emulsions, hydrodispersions are low-emulsifier (less than or equal to 0.1 wt%) or emulsifier-free preparations. The stability of these preparations is achieved through the presence of a gelling agent or thickener, which forms a gel framework in which the inner lipid phase is suspended. Examples of typical gelling agents are homopolymers or copolymers of acrylic acid and / or acrylamide and their derivatives.

[0019] If active ingredients are to be incorporated into a cosmetic preparation and be able to exert their full efficacy, it must be ensured that they are made bioavailable at an effective concentration. In hydrodispersions, which have a high water content, this is not a problem for highly water-soluble active ingredients. However, incorporating poorly water-soluble active ingredients, such as alkylamidothiazoles, into hydrodispersions presents various challenges, including odor stability and light stability of the active ingredient in relation to the formulation. Another problem is that active ingredients like alkylamidothiazoles tend to crystallize in cosmetic preparations. Crystallization of a component in a cosmetic preparation can compromise the quality of the preparation and make the products less appealing to the consumer.If an active ingredient is affected by crystallization, this also has an impact on the effectiveness of the product, as the bioavailability of the active ingredient is reduced.

[0020] In conventional cosmetic preparations, active ingredients are often stabilized and kept in solution by the addition of emulsifiers, thus preventing crystallization. However, due to the chemical structure of the emulsifier molecules, the addition of emulsifiers alters the cosmetic preparation with regard to its skin compatibility and / or sensory properties.

[0021] Furthermore, it is possible to dissolve active ingredients that are not water-soluble by adding ethoxylated solubilizers, so-called PEG derivatives, in particular PEG-hydrogenated castor oil or ethanol. For environmental reasons, the use of polyethylene glycol derivatives is increasingly being avoided. There is a fundamental need for PEG-free preparations containing non-water-soluble active ingredients, such as alkylamidothiazoles.

[0022] Since UV radiation can exacerbate hyperpigmentation reactions, anti-hyperpigmentation agents are often combined with UV sunscreens. It has been shown that emulsifier-free formulations, especially those marketed for sensitive skin, have the disadvantage that UV protection is difficult to adjust. With the same sun protection factor, emulsifier-free preparations are generally characterized by a higher concentration of UV filters compared to conventional emulsions.

[0023] One object of the present invention was to eliminate the disadvantages of the prior art. Consequently, it was an object of the present invention to provide emulsifier-free or low-emulsifier cosmetic preparations that stabilize active ingredients that tend to crystallize. A further object of the present invention was to provide emulsifier-free or low-emulsifier cosmetic preparations containing alkylamidothiazoles and sunscreens, such that none of the active ingredients crystallize.

[0024] Another object of the present invention was to provide emulsifier-free or low-emulsifier cosmetic preparations which serve to lighten human skin.

[0025] Surprisingly for those skilled in the art, it has now been found that the problem of crystallization of alkylamidothiazoles in cosmetic hydrodispersions without the addition of emulsifiers could be solved by the present invention.

[0026] The present invention relates to a cosmetic and / or dermatological preparation in the form of a hydrodispersion comprising a lipid phase and an external aqueous phase containing: a. One or more alkylamidothiazoles b. Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer c. One or more polyols characterized in that it contains further emulsifiers in a proportion of less than 0.1 wt.%, preferably less than 0.05 wt.% and particularly preferably 0 wt.%.

[0027] The present invention relates to a cosmetic and / or dermatological preparation in the form of a hydrodispersion comprising a lipid phase and an external aqueous phase containing: a. One or more alkylamidothiazoles b. Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer c. One or more polyols d. At least one sunscreen filter, characterized in that it contains further emulsifiers in a proportion of less than 0.1 wt.%, preferably less than 0.05 wt.% and particularly preferably 0 wt.%. A further aspect of the invention is the use of the cosmetic and / or dermatological preparation according to the invention for lightening human skin.

[0028] If this disclosure provides information on the crystallization of active ingredients, all information refers to measurements taken using crossed polarization microscopy with an Olympus BX53 microscope. For the measurements, the preparations were first manufactured and then stored at room temperature (normal conditions) for 24 hours until microscopy. Subsequently, microscopic images were taken with the aforementioned microscope (at 20x magnification, at room temperature) and the images were evaluated.

[0029] Where weight percentages (wt%) are given below without reference to a specific composition or mixture, these percentages always refer to the total weight of the cosmetic cleansing preparation. Where ratios of components / substances / groups of substances are disclosed below, these ratios refer to the weight ratios of the components / substances / groups of substances mentioned.

[0030] The terms “according to the invention”, “advantageous according to the invention”, “advantageous in the sense of the present invention”, etc., always refer, within the scope of the present disclosure, to both the preparation according to the invention and the use according to the invention.

[0031] Unless otherwise stated, all tests were conducted under standard conditions. "Standard conditions" means 20°C, 1013 hPa, and a relative humidity of 50%.

[0032] When the term skin is used, it preferably refers to human skin.

[0033] Unless otherwise described in this disclosure, emulsifiers are defined as follows:

[0034] Emulsifiers are defined as all substances listed as "emulsifying agents" in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010 (ISBN 1-882621-47-6). Surfactants are defined as all substances listed as "surfactants" in the International Cosmetic Ingredient Dictionary and Handbook, Thirteenth Edition 2010 (ISBN 1-882621-47-6).

[0035] Preferably, hydrodispersions are characterized by the fact that a gel matrix is ​​built up by a gelling agent in which the inner lipid phase is suspended.

[0036] Preferably, hydrodispersions are characterized in that a gel framework is built up by hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer in which the inner lipid phase is suspended.

[0037] The preparation according to the invention is characterized in that it contains alkylamidothiazoles. Advantageous alkylamidothiazoles within the meaning of the present invention are substances having the general structural formula shown below. at which

[0038] R 1 , R 2 , X and Y can be different, partially the same or completely the same and can mean independently of each other:

[0039] R 1= -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs-Cyc-loalkyl, -Ci-Cs-Cycloalkyl-Alkylhydroxy, -C1-C24 Alkylhydroxy (linear and branched), -C1-C24 Alkylamine (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylaryl-Alkyl-Hydroxy (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), -C1-C24-Alkyl-O-Ci-C24-Alkyl (linear and branched), -C1-C24 Alkyl-Morpholino, -C1-C24 Alkyl-Piperidino, -C1-C24 Alkyl-Piperazino, -C1-C24 Alkyl-piperazino-N-alkyl means,

[0040] R 2 = -H, -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs- Cycloalkyl, -Ci-C24-Hydroxyalkyl (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), means,

[0041] X = -H, -Ci-C24-alkyl (linear and branched), -Ci-C24-alkenyl (linear and branched), -Ci-Cs-cycloalkyl, -Ci-C24-aryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -Ci-C24-heteroaryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -Ci-C24-alkylaryl (linear and branched), -Ci-C24-alkylheteroaryl (linear and branched), -aryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl means,

[0042] Y = -H, -Ci-C24-alkyl (linear and branched), -Ci-C24-alkenyl (linear and branched), -Ci-Cs-cycloalkyl, -Ci-C24-aryl, -Ci-C24-heteroaryl, -Ci-C24-alkylaryl (linear and branched), -Ci-C24-alkylheteroaryl (linear and branched), -aryl, -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydrohydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, -COO-alkyl, -COO-alkenyl, -COO-cycloalkyl, -COO-aryl, -COO-heteroaryl, and X, Y may optionally also mean = condensed aromatic, where X and Y are mutually aromatic or aliphatic homo- or heterocyclic ring systems with up to n ring-forming atoms can form, and where the number n can take values ​​from 5 to 8, and the respective ring systems can in turn be substituted with up to n - 1 alkyl groups, hydroxyl groups, carboxyl groups, amino groups, nitrile functions, sulfur-containing substituents, ester groups and / or ether groups.

[0043] The aforementioned thiazoles can exist both as free bases and as salts: e.g., as fluoride, chloride, bromide, iodide, sulfate, carbonate, ascorbate, acetate, or phosphate. In particular, they exist as halogen salts, such as chloride and bromide.

[0044] Furthermore, an advantageous realization of the present invention consists in cosmetic or dermatological preparations containing an effective amount of one or more of the aforementioned alkylamidothiazoles.

[0045] According to the invention, the aforementioned alkylamidothiazoles are also used for the treatment and / or prophylaxis of unwanted skin pigmentation. This treatment and / or prophylaxis of unwanted skin pigmentation can be carried out in both cosmetic and pharmaceutical contexts.

[0046] Pharmaceutical (or dermatological) treatment is primarily understood to refer to pathological skin conditions, whereas cosmetic treatment and / or prophylaxis of unwanted skin pigmentation primarily concerns healthy skin.

[0047] Advantageously, X is chosen from the group of substituted phenyls, where the substituents (Z) can be chosen from the group -H, -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN, Acetyl and can be the same or different.

[0048] Particularly advantageous is X chosen from the group of phenyl groups substituted with one or more hydroxy groups, wherein the substituent (Z) can be chosen from the group -H, -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN, Acetyl and the following generic structure is preferred, in which Y, R 1 and R 2 which may have the aforementioned properties.

[0049] Connections are particularly advantageous in which

[0050] Y = H

[0051] R 1 = -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs-Cyc-loalkyl, -Ci-Cs-Cycloalkyl-Alkylhydroxy, -Ci-C24 Alkylhydroxy (linear and branched), -Ci-C24 Alkylamine (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylaryl-Alkyl-Hydroxy (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), -Ci-C24-Alkyl-O-Ci-C24-Alkyl (linear and branched), -Ci-C24 Alkyl-Morpholino, -Ci-C24 Alkyl-Piperidino, -Ci-C 24 Alkyl-Piperazino, -Ci-C24 Alkyl-Piperazino-N-Alkyl means,

[0052] R 2 = -H, -Ci-C24-Alkyl (linear and branched),

[0053] Z = -H, -OH, -F, -Cl, -Br, -I, -OMe, -NH2, -CN, acetyl.

[0054] Particularly preferred are those connections in which

[0055] Y = H

[0056] R 1 = -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs-Cyc-loalkyl, -Ci-Cs-Cycloalkyl-Alkylhydroxy, -C1-C24 Alkylhydroxy (linear and branched), -C1-C24 Alkylamine (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylaryl-Alkyl-Hydroxy (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), -C1-C24-Alkyl-O-Ci-C24-Alkyl (linear and branched), -C1-C24 Alkyl-Morpholino, -C1-C24 Alkyl-Piperidino, -C1-C24 Alkyl-Piperazino, -C1-C24 Alkyl-piperazino-N-alkyl means,

[0057] R 2 = -H.

[0058] According to the invention, the connections are preferred.

[0059] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide

[0060] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide

[0061] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramide

[0062] A / -(4-(2,4-dihydroxyphenyl)thiazol-2-yl)heptanamide

[0063] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-6-hydroxyhexanamide

[0064] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-3-hydroxypropanamide

[0065] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-methoxyacetamide

[0066] 3-amino- / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)propanamide

[0067] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)acetamide

[0068] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexane-1 -carboxamide

[0069] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide und

[0070] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide

[0071] Ganz besonders bevorzugt ist die Verbindung

[0072] / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide

[0073] The aforementioned alkylamidothiazoles, their synthesis, and their applications were discussed in the

[0074] EP2758381A1 described.

[0075] The preparation according to the invention is characterized in that it contains water. Furthermore, it is advantageous if the cosmetic hydrodispersion preparation according to the present invention contains water as a cosmetic carrier, wherein the water is present in a proportion of 60% to 90% by weight, preferably 65% ​​to 85% by weight, based on the total weight of the preparation.

[0076] The preparation according to the invention is characterized in that it contains compounds having the INCI names Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer. This is available, for example, under the trade name Sepinov™ EMT 10 from the company Seppic.

[0077] Advantageously according to the invention, these compounds have the molecular formula [CyHielXhSO^n [CsHsChJm], which corresponds to a statistical structural formula as follows.

[0078] If Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer is included, it is advantageous if the proportion of this component is from 0.1 wt.% to 4.0 wt.%, preferably from 0.3 wt.% to 3.0 wt.%, and particularly preferably from 0.5 wt.% to 2.5 wt.%, based on the total weight of the preparation.

[0079] However, if emulsifying and / or washing-active substances are contained in the preparation due to raw material impurities or other contamination, these preparations are still considered to be free of emulsifiers and surfactants according to the invention, provided that the proportion does not exceed 0.1% by weight based on the total weight of the hydrodispersion preparation.

[0080] Hydrocolloids, which can also have emulsifying properties, are not counted among the emulsifiers to be excluded, since their main function is not that of an emulsifier.

[0081] According to the invention, the cosmetic preparation is characterized in that it contains one or more polyols. Polyols are chemical compounds that contain at least two hydroxyl groups. Therefore, polyols belong to the group of polyhydric alcohols.

[0082] The at least one polyol can advantageously be selected from the group consisting of 1,3-propylene glycol, 1,2-propylene glycol, dipropylene glycol, butylene glycol (INCI: Butylene Glycol), ethylene glycol, methylpropanediol (INCI: Methylpropanediole), panthenol, ethylhexylglycerin, 1,2-octanediol (INCI: Caprylyl Glycol), pentane glycol (INCI: Pentylene Glycol), and 1,2-hexanediol (INCI: 1,2-Hexanediol). Glycerin is not a polyol within the meaning of this invention.

[0083] Particularly advantageous in the sense of the present invention is the selection of at least one polyol from the compounds: 1,3-propylene glycol, dipropylene glycol, methylpropanediol, 1,2-hexanediol, butylene glycol, 1,2-propylene glycol, pentylene glycol and / or caprylyl glycol.

[0084] Furthermore, it is advantageous in the sense of the invention if the total proportion of polyols, in particular of the polyols previously listed as particularly advantageous, in the preparation according to the invention is 0.5 to 30 wt.%, preferably 1 wt.% to 20 wt.% and particularly preferably 2 to 10 wt.% based on the total weight of the preparation.

[0085] Another preferred embodiment of the invention is characterized in that methylpropanediol is contained in the preparation according to the invention in a proportion of 0.5 to 6 wt.%, preferably 1 to 5 wt.% and particularly preferably 2 to 4 wt.% based on the total weight of the cleaning preparation.

[0086] Another preferred embodiment of the invention is characterized in that butylene glycol is contained in the preparation according to the invention in a proportion of 0.5 to 12 wt. %, preferably 2 to 10 wt. %, and particularly preferably 4 to 6 wt. %, based on the total weight of the cleaning preparation.

[0087] Another preferred embodiment of the invention is characterized in that pentylene glycol is contained in the preparation according to the invention in a proportion of 0.05 to 1 wt.%, preferably 0.1 to 0.8 wt.% and particularly preferably 0.1 to 0.6 wt.% based on the total weight of the cleaning preparation.

[0088] Furthermore, it is preferred in accordance with the present invention if the preparation is free of ethanol.

[0089] The preparation according to the invention may advantageously contain preservatives. Preservatives are those preservative substances that are authorized for use in cosmetic products in accordance with the German Cosmetics Regulation and Regulation (EC) No. 1223 / 2009 on cosmetic products for use in cosmetic products in Europe.

[0090] The at least one preservative can advantageously be selected from the group consisting of hydroxyacetophenones, phenoxyethanol, sodium benzoate (INCI: Sodium Benzoate) and / or benzyl alcohol (INCI: Benzyl Alcohol). Advantageously, the proportion of the at least one preservative, in particular the preservatives previously listed as particularly advantageous, in the preparation according to the invention is 0.1 wt.% to 2.0 wt.%, preferably 0.4 wt.% to 1.5 wt.%, and particularly preferably 0.7 wt.% to 1.1 wt.%, based on the total weight of the cleaning preparation.

[0091] A preferred embodiment of the invention is characterized in that hydroxyacetophenone is contained in the cosmetic preparation according to the invention in a proportion of 0.1 wt.% to 2.0 wt.%, preferably 0.2 wt.% to 1.5 wt.% and particularly preferably 0.2 wt.% to 1.0 wt.%, based on the total weight of the preparation.

[0092] The preparation according to the invention can advantageously contain at least one fatty alcohol comprising 10-30 carbon atoms. The at least one fatty alcohol can advantageously be selected from the group consisting of myristyl alcohol (INCI: Myristyl Alcohol), cetyl alcohol (INCI: Cetyl Alcohol), stearyl alcohol (INCI: Stearyl Alcohol) and / or cetearyl alcohol (INCI: Cetearyl Alcohol).

[0093] By definition, fatty alcohols containing 10-30 carbon atoms are not considered emulsifiers.

[0094] A preferred embodiment of the invention is characterized in that cetearyl alcohol is contained in the preparation according to the invention in a proportion of 0.1 to 5.0 wt.%, preferably 0.5 to 3.0 wt.% and particularly preferably 0.7 to 2.0 wt.% based on the total weight of the hydrodispersion preparation.

[0095] The preparation according to the invention may advantageously contain glycerin. If glycerin is included, it is advantageous if the proportion of this component is from 2.0 wt.% to 15.0 wt.%, preferably from 3.0 wt.% to 12.0 wt.%, and particularly preferably from 5.0 wt.% to 10.0 wt.%, based on the total weight of the hydrodispersion preparation.

[0096] Furthermore, the preparation according to the invention can advantageously contain at least one chelating agent. The at least one chelating agent can advantageously be selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), disodium EDTA, calcium disodium EDTA, trisodium EDTA and tetrasodium EDTA.

[0097] A preferred embodiment of the invention is characterized in that trisodium EDTA is contained in the preparation according to the invention in a proportion of 0.05 to 0.5 wt.%, preferably 0.1 to 0.3 wt.% based on the total weight of the hydrodispersion preparation.

[0098] Furthermore, the preparation according to the invention can advantageously contain at least one biopolymer. The at least one biopolymer can advantageously be selected from the group consisting of tapioca starch, gellan gum, xanthan gum, dehydroxanthan gum, sclerotium gum, and / or carrageenan gum. The biopolymers listed as advantageous in this invention, in particular tapioca starch, gellan gum, xanthan gum, dehydroxanthan gum, sclerotium gum, and / or carrageenan gum, are not to be classified as hydrocolloids within the meaning of this invention.

[0099] The preparation according to the invention may advantageously contain tapioca starch. If tapioca starch is included, it is advantageous if the proportion of this component is from 0.5 wt.% to 7.0 wt.%, preferably from 1.0 wt.% to 5.0 wt.%, and particularly preferably from 1.5 wt.% to 3.0 wt.%, based on the total weight of the hydrodispersion preparation.

[0100] The preparation according to the invention may advantageously contain gellan gum. If gellan gum is included, it is advantageous if the proportion of this component is from 0.05 wt.% to 2.0 wt.%, preferably from 0.07 wt.% to 1.0 wt.%, and particularly preferably from 0.08 wt.% to 0.5 wt.%, based on the total weight of the hydrodispersion preparation.

[0101] The preparation according to the invention may advantageously contain xanthan gum. If xanthan gum is included, it is advantageous if the proportion of this component is from 0.05 wt.% to 2.0 wt.%, preferably from 0.07 wt.% to 1.0 wt.%, and particularly preferably from 0.08 wt.% to 0.5 wt.%, based on the total weight of the hydrodispersion preparation.

[0102] Furthermore, the preparation according to the invention can advantageously contain at least one antioxidant selected from the group consisting of tocopherol, ethyl ascorbic acid, diethylhexyl syringylidenemalonate (and) caprylic / capric triglyceride and / or tocopherol (and) Helianthus annuus (sunflower) seed oil.

[0103] If tocopherol is included, it is advantageous if the proportion of this component is from 0.5 wt.% to 7.0 wt.%, preferably from 1.0 wt.% to 5.0 wt.%, and particularly preferably from 1.5 wt.% to 3.0 wt.%, based on the total weight of the hydrodispersion preparation.

[0104] The lipid phase according to the invention can contain one or more substances from the following group:

[0105] • Oils, such as triglycerides of capric or caprylic acid

[0106] • Fats, waxes and other natural and synthetic fats, preferably esters of fatty acids with low-carbon alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with low-carbon alkanoic acids or with fatty acids

[0107] • Alkylbenzoates

[0108] Advantageously, the oil phase is selected from the group consisting of dibutyl adipate, C12-15 alkyl benzoate, dicaprylyl carbonate and cetearyl isononanoate.

[0109] Mixtures of dibutyl adipate and C12-15 alkyl benzoate or mixtures of dicaprylyl carbonate and cetearyl isononanoate are particularly advantageous.

[0110] A preferred embodiment of the invention is characterized in that dibutyl adipate is contained in the preparation according to the invention in a proportion of 0.1 to 7.0 wt.%, preferably 1.0 to 5.0 wt.%, and particularly preferably 2.0 to 4.0 wt.%, based on the total weight of the hydrodispersion preparation. A preferred embodiment of the invention is characterized in that C12-15 alkyl benzoate is contained in the preparation according to the invention in a proportion of 1.0 to 10.0 wt.%, preferably 2.0 to 7.0 wt.%, and particularly preferably 3.0 to 6.0 wt.%, based on the total weight of the hydrodispersion preparation.

[0111] A preferred embodiment of the invention is characterized in that dicaprylyl carbonate is contained in the preparation according to the invention in a proportion of 0.1 to 5.0 wt.%, preferably 0.5 to 3.0 wt.% and particularly preferably 1.0 to 2.5 wt.% based on the total weight of the hydrodispersion preparation.

[0112] A preferred embodiment of the invention is characterized in that cetearyl isononanoate is contained in the preparation according to the invention in a proportion of 1.0 to 10.0 wt.%, preferably 1.5 to 8.0 wt.% and particularly preferably 2.0 to 7.0 wt.% based on the total weight of the hydrodispersion preparation.

[0113] Furthermore, the hydrodispersion according to the invention can contain one or more UV light protection filters.

[0114] Advantageous embodiments of the present invention are characterized in that the hydrodispersion preparation contains one or more UV light protection filters selected from the group of UV light protection filters approved according to the cosmetics regulation.

[0115] If one or more UV light protection filters are included, it is advantageous if the total proportion of these components is from 0.01 wt.% to 40.0 wt.%, preferably from 1.0 wt.% to 20.0 wt.%, and particularly preferably from 5.0 wt.% to 10.0 wt.%, based on the total weight of the hydrodispersion preparation.

[0116] A preferred embodiment of the invention is characterized in that a combination of bis-ethylhexyloxyphenol methoxyphenyl triazine, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, and / or ethylhexyl triazone is contained in the preparation according to the invention in a total proportion of 0.01 wt.% to 40.0 wt.%, preferably 1.0 wt.% to 20.0 wt.%, and particularly preferably 5.0 wt.% to 10.0 wt.%, based on the total weight of the hydrodispersion preparation. Comparative tests and examples

[0117] The following examples are intended to illustrate the present invention without limiting it. Unless otherwise stated, all quantities, proportions, and percentages are based on the weight and total quantity or total weight of the preparations.

[0118] The following formulations were prepared for the comparative tests. Formulation Cf. 1 is not according to the invention, while Ex. 1 is according to the invention.

[0119] The formation of alkylamidothiazole crystals was determined microscopically as described above. The hydrodispersion preparations listed above were prepared, and their properties were investigated in a comparative experiment with regard to the crystallization of alkylamidothiazoles. For hydrodispersions according to the invention, it was shown that the preparations exhibited no crystallization after a time of 24 h. In contrast, hydrodispersions that were not according to the invention showed the formation of alkylamidothiazole crystals after 24 h.

[0120] The following examples are intended to further illustrate the invention without limiting it:

Claims

Patent claims 1. A cosmetic and / or dermatological preparation in the form of a hydrodispersion comprising a lipid phase and an external aqueous phase containing: a. One or more alkylamidothiazoles b. Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer c. One or more polyols, characterized in that it contains further emulsifiers in the proportion of less than 0.1 wt.%, preferably less than 0.05 wt.%, and particularly preferably 0 wt.%.

2. Preparation according to claim 1 characterized in that the content of alkylamidothiazoles is from 0.000001 to 10.0 wt.%, preferably from 0.0001 to 3.0 wt.% and particularly preferably from 0.001 to 1.0 wt.% based on the total weight of the cosmetic cleaning preparation.

3. Preparation according to one of the preceding claims characterized in that the alkylamidothiazole(s) are substances of the general formula is or are, at which R 1 , R 2 X and Y can be different, partially the same, or completely the same, and can mean things independently of each other: R 1 = -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs- Cycloalkyl, -Ci-Cs-Cycloalkyl-Alkylhydroxy, -C1-C24 Alkylhydroxy (linear and branched), -C1-C24 Alkylamine (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -C1-C24-Alkylaryl-Alkyl-Hydroxy (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), -Ci-C24-Alkyl-O-Ci-C24-Alkyl (linear and branched), -C1-C24 Alkyl-Morpholino, -C1-C24 Alkyl-Piperidino, -C1-C24 Alkyl-Piperazino, -C1-C24 Alkyl-piperazino-N-alkyl means, R 2= H, -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -Ci-Cs-Cycloalkyl, -Ci-C24-Hydroxyalkyl (linear and branched), -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), means, X = -H, -Ci-C24-alkyl (linear and branched), -Ci-C24-alkenyl (linear and branched), -Ci-Cs-cycloalkyl, -Ci-C24-aryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -Ci-C24-heteroaryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -Ci-C24-alkylaryl (linear and branched), -Ci-C24-alkylheteroaryl (linear and branched), -aryl (possibly singly or multiply substituted with -OH, -F, -CI, -Br, -I, -OMe, -NH2, -CN), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl means, Y = H, -Ci-C24-Alkyl (linear and branched), -Ci-C24-Alkenyl (linear and branched), -C1-Cs-Cycloalkyl, -Ci-C24-Aryl, -Ci-C24-Heteroaryl, -Ci-C24-Alkylaryl (linear and branched), -Ci-C24-Alkylheteroaryl (linear and branched), -Aryl, -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-Dimethoxyphenyl, -2,3-Dimethoxyphenyl, -COO-Al-kyl, -COO-Alkenyl, -COO-Cycloalkyl, -COO-Aryl, -COO-Heteroaryl, means, The alkylamidothiazoles can exist both as a free base and as salts that can be used cosmetically and / or dermatologically.

4. Preparation according to one of the preceding claims characterized in that the alkylamidothiazole(s) have the following structures: A / -(4-(2,4-dihydroxyphenyl)thiazol-2-yl)pivalamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)isobutyramide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)butyramide A / -(4-(2,4-dihydroxyphenyl)thiazol-2-yl)heptanamide / \ / -(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-6-hydroxyhexanamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-3-hydroxypropanamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-methoxyacetamide 3-amino- / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)propanamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)acetamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-4-(hydroxymethyl)cyclohexane-1-carboxamide / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)cyclohexanecarboxamide and / V-(4-(2,4-dihydroxyphenyl)thiazol-2-yl)-2-(4-(hydroxymethyl)phenyl)acetamide 5. Preparation according to one of the preceding claims characterized in that the alkylamidothiazole(s) can be present as halide, carbonate, ascorbate, sulfate and / or phosphate.

6. Preparation according to one of the preceding claims characterized in that it contains Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, wherein it is further preferred that the total proportion of Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer is 0.1 wt.% to 4.0 wt.%, preferably 0.3 wt.% to 3.0 wt.%, and particularly preferably 0.5 wt.% to 2.5 wt.%, based on the total weight of the preparation.

7. Preparation according to one of the preceding claims characterized in that the at least one polyol is / are selected from the group consisting of 1,3-propylene glycol, 1,2-propylene glycol, dipropylene glycol, butylene glycol (INCI: Butylene Glycol), ethylene glycol, methylpropanediol (INCI: Methylpropanediole), panthenol, ethylhexylglycerin, 1,2-octanediol (INCI: Caprylyl Glycol), pentane glycol (INCI: Pentylene Glycol), 1,2-hexanediol (INCI: 1,2-Hexanediol).

8. Preparation according to one of the preceding claims characterized in that the total proportion of these polyols is from 0.5 to 30 wt.%, preferably from 1 wt.% to 20 wt.% and particularly preferably from 2 to 10 wt.% based on the total weight of the preparation.

9. Preparation according to one of the preceding claims characterized in that it contains trisodium EDTA, wherein it is further preferred that the total proportion of trisodium EDTA is 0.05 to 0.5 wt.%, preferably 0.1 to 0.3 wt.%, based on the total weight of the preparation.

10. Preparation according to one of the preceding claims characterized in that the preparation contains one or more UV light protection filters, wherein it is further preferred if the total proportion of UV light protection filters is from 0.01 wt.% to 40.0 wt.%, preferably from 1.0 wt.% to 20.0 wt.%, and particularly preferably from 5.0 wt.% to 10.0 wt.%, based on the total weight of the preparation.

11. Preparation according to one of the preceding claims, characterized in that the proportion of water is 60 to 95 wt.%, in particular preferably 70 to 85 wt.% based on the total weight of the preparation.

12. Use of the preparation according to any of the preceding claims for lightening human skin.

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