Laboratory-on-a-chip consumable with functionalizable reaction chamber and reaction chamber functionalization method

The laboratory-on-a-chip consumable with direct access channels for reaction chamber functionalization addresses the challenge of non-specific binding, enhancing the specificity and sensitivity of ELISA assays by using metal-ionic complexes and sealing to maintain fluid flow integrity.

WO2026125527A1 Publication Date: 2026-06-18BIOTHINK TECH SL
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
BIOTHINK TECH SL
Filing Date
2025-12-10
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Existing laboratory-on-a-chip devices face challenges in effectively functionalizing the reaction chamber due to difficulties in accessing and maintaining the integrity of the surface, leading to non-specific binding and increased false positives in ELISA assays.

⚗Method used

A laboratory-on-a-chip consumable with direct access channels to the reaction chamber, allowing selective functionalization using metal-ionic complexes, followed by sealing to prevent contamination and maintain fluid flow integrity.

🎯Benefits of technology

Enhances the specificity and sensitivity of ELISA assays by reducing non-specific binding and maintaining fluid flow, thereby improving the accuracy and reproducibility of results.

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Abstract

Laboratory-on-a-chip consumable (10) provided with a reaction chamber (5) configured to contain a fluid sample, one or more direct access channels (2) for the functionalization of the reaction chamber (5), where the direct access channels (2) are through holes that extend from the surface of the consumable (10) to the reaction chamber (5), arranged to exclusively functionalize the surface of the reaction chamber (5). By virtue of this functionalization, the capacity to specifically bind the capturing agent in the reaction chamber without affecting the adjacent hydrophobic microfluidic channels is increased, thus reducing contamination and the presence of nonspecific signals generated by the binding of the antibodies to the base material.
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