Skin absorption-promoting composition comprising water-soluble active ingredient

Abstract

The present invention relates to a composition for promoting skin absorption of a water-soluble active ingredient. Specifically, the present invention provides a cosmetic composition or a topical skin composition, in which an amphiphilic solvent and a highly polar oil are used to allow the water-soluble active ingredient to penetrate deeply into the lipid-based skin barrier composed of lipids, whereby the composition has excellent usability while maintaining superior activity of the active ingredient.

Description

Skin absorption enhancing composition containing water-soluble active ingredients

[0001] This patent application claims priority to Korean Patent Application No. 10-2024-0184481 filed with the Korean Intellectual Property Office on December 12, 2024, and the disclosures of said patent application are incorporated herein by reference.

[0002] The present invention relates to a composition for enhancing the absorption of a water-soluble active ingredient into the skin, and more specifically, to a cosmetic composition or a topical skin composition that uses an amphiphilic solvent and a highly polar oil to enable a water-soluble active ingredient to penetrate deeply into a skin barrier composed of lipids.

[0003] In modern society, as the demand for skin beauty and health increases, functional substances for skin improvement and cosmetics containing them are being developed. For example, niacinamide, tranexamic acid, arbutin, and ascorbic acid are known as functional substances that contribute to skin whitening, and adenosine is known as a functional substance that contributes to improving skin wrinkles.

[0004] However, among these functional ingredients, water-soluble functional ingredients (hereinafter water-soluble active ingredients) may not be absorbed deep into the skin due to the skin barrier.

[0005] Specifically, the skin is composed of the epidermis, dermis, and subcutaneous fat layer, and as the body's outermost membrane, it plays a crucial role in protecting the body from harmful environments and maintaining homeostasis. Among these, the stratum corneum, the outermost layer of the epidermis, is composed of protein-based corneocytes and intercellular lipids.

[0006] Intercellular lipids are composed of ceramides, cholesterol, free fatty acids, cholesterol esters, cholesterol sulfates, and small amounts of phospholipids, and perform the role of a skin barrier by blocking the transdermal penetration of harmful substances and maintaining moisture within the skin.

[0007] In other words, since the skin barrier of the stratum corneum is composed of lipid components as described above, its absorption capacity for water-soluble components may be low.

[0008] Meanwhile, when water-soluble active ingredients are included in a high amount in the composition, there is a problem that stickiness occurs and spreadability becomes stiff, resulting in a reduced user experience.

[0009] Against this backdrop, the inventors have made research efforts to produce a composition with excellent skin penetration power for water-soluble active ingredients. As a result, the inventors have developed a cosmetic composition or a topical skin composition that uses an amphiphilic solvent and a polar oil to increase the affinity for lipid components, thereby penetrating water-soluble active ingredients deep into the skin, and consequently, has excellent usability with minimal sticky residue remaining on the skin surface, while exhibiting excellent activity by acting deep within the skin.

[0010] The object of the present invention is to provide a skin absorption-enhancing cosmetic composition comprising: a water-soluble active ingredient; an amphiphilic solvent comprising one or more of dimethyl isosorbide and ethoxydiglycol; and a polar oil comprising propylene glycol caprylate.

[0011] Another objective of the present invention is to provide a skin absorption-enhancing topical skin composition comprising: a water-soluble active ingredient; an amphiphilic solvent comprising one or more of dimethyl isosorbide and ethoxydiglycol; and a polar oil comprising propylene glycol caprylate.

[0012] The present invention relates to a cosmetic or topical skin composition that uses an amphiphilic solvent and a polar oil to increase the affinity for lipid components, thereby enabling water-soluble active ingredients to be absorbed deep into the skin.

[0013] According to the prior art regarding compositions containing existing water-soluble active ingredients, water-soluble ingredients are not absorbed deep into the skin due to the skin barrier composed of lipids, and a significant amount remains on the surface of the skin. On the other hand, the present invention uses an amphiphilic solvent and a polar oil to increase the solubility of lipid ingredients, so they can penetrate deep into the skin barrier composed of lipids. Consequently, the amount of sticky ingredients remaining on the skin is small, resulting in excellent usability, and because it acts deep within the skin, the activity of the active ingredients is excellent.

[0014] The present invention will be described in more detail below.

[0015]

[0016] One aspect of the present invention is a skin absorption-enhancing cosmetic composition comprising: a water-soluble active ingredient; an amphiphilic solvent comprising one or more of dimethyl isosorbide and ethoxydiglycol; and a polar oil comprising propylene glycol caprylate.

[0017] In the present invention, any water-soluble active ingredient that can be dissolved in water to form an aqueous phase may be used. For example, it may be an ingredient with a molecular weight of 500 g / mol or less, specifically 300 g / mol or less. As another example, it may be niacinamide, tranexamic acid, arbutin, ascorbic acid, or derivatives thereof as whitening ingredients, or adenosine or derivatives thereof as wrinkle-improving functional ingredients, or a mixture of the above ingredients, but is not limited thereto. The water-soluble active ingredient is not limited to functional ingredients and may be an ingredient that is soluble in an aqueous phase, such as a natural extract.

[0018] In the present invention, the water-soluble active ingredient is present in an amount of 0.00001 to 30 wt%, 0.00001 to 20 wt%, 0.00001 to 15 wt%, 0.00001 to 10 wt%, 0.01 to 30 wt%, 0.01 to 20 wt%, 0.01 to 15 wt%, 0.01 to 10 wt%, 1 to 30 wt%, 1 to 20 wt%, 1 to 15 wt%, 1 to 10 wt%, 2 to 30 wt%, 2 to 20 wt%, 2 to 15 wt%, 2 to 10 wt%, 3 to 30 wt%, 3 to 20 wt%, 3 to 15 wt%, 3 to 10 wt%, 4 to 30 wt%, and 4 to 20 wt% relative to the total cosmetic composition. It may contain 4 to 15 weight%, 4 to 10 weight%, 10 to 30 weight%, 10 to 20 weight%, or 10 to 15 weight%, and specifically, it may be included in a high content of 10 to 30 weight%, but is not limited thereto. If the water-soluble active ingredient is less than 0.00001 weight%, the active effect may be negligible, and if it exceeds 30 weight%, the skin absorption enhancement effect, the stability of the composition, or the feel of use may be reduced.

[0019] In the present invention, the amphiphilic solvent comprises 0.1 to 60 wt%, 0.1 to 50 wt%, 0.1 to 40 wt%, 0.1 to 30 wt%, 0.1 to 20 wt%, 0.1 to 10 wt%, 0.1 to 6 wt%, 1 to 60 wt%, 1 to 50 wt%, 1 to 40 wt%, 1 to 30 wt%, 1 to 20 wt%, 1 to 10 wt%, 1 to 6 wt%, 2 to 60 wt%, 2 to 50 wt%, 2 to 40 wt%, 2 to 30 wt%, 2 to 20 wt%, 2 to 10 wt%, 2 to 6 wt%, 3 to 60 wt%, 3 to 50 wt%, 3 to 40 wt%, 3 to It may contain 30 wt%, 3 to 20 wt%, 3 to 10 wt%, 3 to 6 wt%, 4 to 60 wt%, 4 to 50 wt%, 4 to 40 wt%, 4 to 30 wt%, 4 to 20 wt%, 4 to 10 wt%, 4 to 6 wt%, 5 to 60 wt%, 5 to 50 wt%, 5 to 40 wt%, 5 to 30 wt%, 5 to 20 wt%, 5 to 10 wt%, and 5 to 6 wt%, but is not limited thereto. If the amphiphilic solvent is less than 0.1 wt%, the effect of enhancing skin absorption of the water-soluble active ingredient, formulation stability, or stickiness improvement may be reduced, and if it exceeds 60 wt%, skin irritation may increase, making it unsuitable as a cosmetic composition.

[0020] In the present invention, the amphiphilic solvent may comprise one or more selected from the group consisting of isosorbide-based compounds, ethoxydiglycol-based compounds, and 2,3-butanediol.

[0021] In the present invention, the isosorbide-based compound may comprise one or more selected from the group consisting of dimethyl isosorbide, isosorbide, isosorbide dicaprylate, isosorbide disunflowersidet, isosorbide laurate, isosorbide oleate, and isosorbide dicaprylate / caprate, and preferably may be dimethyl isosorbide, but is not limited thereto.

[0022] In the present invention, the ethoxydiglycol-based compound may be one or more selected from the group consisting of ethoxydiglycol, diethoxydiglycol, bis-ethoxydiglycol succinate, and ethoxydiglycol acetate, and preferably may be ethoxydiglycol, but is not limited thereto.

[0023] In the present invention, the dimethyl isosorbide may be included in an amount of 0.1 to 50 wt%, 0.1 to 40 wt%, 0.1 to 30 wt%, 0.1 to 20 wt%, 0.1 to 10 wt%, 0.1 to 5 wt%, 1 to 50 wt%, 1 to 40 wt%, 1 to 30 wt%, 1 to 20 wt%, 1 to 10 wt%, 1 to 5 wt%, 4 to 50 wt%, 4 to 40 wt%, 4 to 30 wt%, 4 to 20 wt%, 4 to 10 wt%, and 4 to 5 wt% relative to the total cosmetic composition, but is not limited thereto. If the above dimethyl isosorbide is less than 0.1 weight%, the skin absorption enhancement effect or the feel of use may be reduced, and if it exceeds 50 weight%, skin irritation may be increased, making it unsuitable as a cosmetic composition.

[0024] In the present invention, the ethoxydiglycol may be included in an amount of 0.1 to 10 wt%, 0.1 to 9 wt%, 0.1 to 8 wt%, 0.1 to 7 wt%, 0.1 to 6 wt%, 0.1 to 5 wt%, 0.1 to 4 wt%, 0.1 to 3 wt%, 0.1 to 2 wt%, 0.1 to 1 wt%, 0.5 to 10 wt%, 0.5 to 9 wt%, 0.5 to 8 wt%, 0.5 to 7 wt%, 0.5 to 6 wt%, 0.5 to 5 wt%, 0.5 to 4 wt%, 0.5 to 3 wt%, 0.5 to 2 wt%, and 0.5 to 1 wt% relative to the total cosmetic composition, but is not limited thereto. If the above ethoxydiglycol is less than 0.1 weight%, the skin absorption enhancement effect or the feel of use may be reduced, and if it exceeds 10 weight%, skin irritation may increase, making it unsuitable as a cosmetic composition.

[0025] In the present invention, the amphiphilic solvent may be included in one or more of the aqueous phase and the oil phase.

[0026] In the present invention, the polar oil may comprise one or more selected from the group consisting of propylene glycol caprylate-based compounds and octyldodecanol, but is not limited thereto.

[0027] In the present invention, the propylene glycol caprylate-based compound may be one or more selected from the group consisting of propylene glycol caprylate, dipropylene glycol caprylate, and PEG-6 propylene glycol caprylate / caprate, and preferably may be propylene glycol caprylate, but is not limited thereto.

[0028] In the present invention, the polar oil may be included in an amount of 0.00001 to 1 weight%, 0.00001 to 0.5 weight%, 0.00001 to 0.2 weight%, 0.01 to 1 weight%, 0.01 to 0.5 weight%, or 0.01 to 0.2 weight% relative to the total cosmetic composition, but is not limited thereto. If the polar oil is less than 0.00001 weight%, the skin absorption enhancing effect may be reduced, and if it exceeds 1 weight%, skin irritation may increase, making it unsuitable as a cosmetic composition.

[0029] In the present invention, the propylene glycol caprylate is present in an amount of 0.00001 to 1 wt%, 0.00001 to 0.5 wt%, 0.00001 to 0.4 wt%, 0.00001 to 0.3 wt%, 0.00001 to 0.2 wt%, 0.01 to 1 wt%, 0.01 to 0.5 wt%, 0.01 to 0.4 wt%, 0.01 to 0.3 wt%, 0.01 to 0.2 wt%, 0.05 to 1 wt%, 0.05 to 0.5 wt%, 0.05 to 0.4 wt%, 0.05 to 0.3 wt%, 0.05 to 0.2 wt%, 0.1 to 1 wt%, and 0.1 to 0.5 wt% relative to the total cosmetic composition. It may contain 0.1 to 0.4 weight%, 0.1 to 0.3 weight%, or 0.1 to 0.2 weight%, but is not limited thereto. If the propylene glycol caprylate is less than 0.00001 weight%, the skin absorption enhancing effect may be reduced, and if it exceeds 1 weight%, skin irritation may increase, making it unsuitable as a cosmetic composition.

[0030] In the present invention, the cosmetic composition may be used to provide an improvement in stickiness or a skin whitening effect.

[0031] In the present invention, the whitening or wrinkle improvement effect of the cosmetic composition can be enhanced to the extent that skin absorption is enhanced.

[0032] In the present invention, the cosmetic composition may additionally include one or more selected from the group consisting of moisturizers, preservatives, solubilizers, and thickeners, but is not limited thereto.

[0033] In the present invention, the humectant may include a polyol, specifically one or more selected from the group consisting of glycerin, butylene glycol, dipropylene glycol, and propanediol, but is not limited thereto.

[0034] In the present invention, the humectant may be included in an amount of 1 to 30 weight%, 1 to 20 weight%, 1 to 15 weight%, 5 to 30 weight%, 5 to 20 weight%, 5 to 15 weight%, for example, 10 weight%, but is not limited thereto.

[0035] In the present invention, the preservative may be one or more selected from the group consisting of 1,2-hexanediol, pentylene glycol, caprylyl glycol, ethylhexylglycerin, hydroxyacetophenone, glyceryl caprylate, and phenoxyethanol, but is not limited thereto.

[0036] In the present invention, the preservative may be included in an amount of 0.1 to 5 weight%, 0.1 to 4 weight%, or 0.1 to 3 weight% relative to the total cosmetic composition, but is not limited thereto.

[0037] In the present invention, the solubilizing agent may be one or more selected from the group consisting of polyglyceryl-10 laurate, C12-14 alkes-12, choles-24, PEG-60 hydrogenated castor oil and glycolipids, but is not limited thereto.

[0038] In the present invention, the solubilizing agent may be included in an amount of 0.00001% to 5% by weight, 0.00001% to 4% by weight, 0.00001% to 3% by weight, 0.1% to 5% by weight, 0.1% to 4% by weight, 0.1% to 3% by weight, 0.1% to 1% by weight, 0.1% to 0.5% by weight, or 0.2% to 0.4% by weight relative to the total cosmetic composition, but is not limited thereto.

[0039] In the present invention, the thickening agent may be one or more selected from the group consisting of acrylate / C10-30 alkyl acrylate crosspolymer, sodium polyacrylate, polyacrylic acid, hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, carbomer, sodium carbomer, potassium carbomer, ammonium acryloyl dimethyl taurate / VP copolymer, polyacrylate crosspolymer-11, sodium polyacryloyl dimethyl taurate, xanthan gum, and hydroxyethyl cellulose, but is not limited thereto.

[0040] In the present invention, the thickening agent may be included in an amount of 0.01 to 5 weight%, 0.01 to 4 weight%, 0.01 to 3 weight%, 0.01 to 2 weight%, 0.01 to 1 weight%, 0.1 to 5 weight%, 0.1 to 4 weight%, 0.1 to 3 weight%, 0.1 to 2 weight%, and 0.1 to 1 weight% relative to the total cosmetic composition, but is not limited thereto.

[0041] In the present invention, the cosmetic composition may further include one or more additives selected from the group consisting of a pH adjuster, a chelating agent, an antioxidant, a pigment, and a fragrance, but is not limited thereto. The pH adjuster, the chelating agent, the antioxidant, the pigment, and the fragrance are not particularly limited in type and weight, and may be used in the form and weight commonly used in the art.

[0042] In the present invention, the cosmetic composition can be prepared in any formulation conventionally manufactured in the art. For example, it may be a transparent formulation, a solubilized formulation, an emulsion formulation, a skin toner, an ampoule, a moisturizing gel, a moisturizing cream, an essence, a two-step essence, a serum, a lotion, a cream, a liquid foundation, or a solid foundation formulation, but is not limited thereto. The cosmetic composition may preferably be a solubilized formulation or an emulsion formulation.

[0043]

[0044] Another aspect of the present invention is a skin absorption-enhancing topical skin composition comprising: a water-soluble active ingredient; an amphiphilic solvent comprising one or more of dimethyl isosorbide and ethoxydiglycol; and a polar oil comprising propylene glycol caprylate.

[0045] In the present invention, the details regarding the water-soluble active ingredient, the amphiphilic solvent, and the polar oil may be those described in other embodiments above.

[0046]

[0047] Throughout this specification, materials, methods, and embodiments are merely illustrative and do not limit the invention. To enable the practice of various embodiments of the invention, descriptions of specific terms are provided:

[0048] The term “Dimethyl Isosorbide (CAS No. 5306-85-4)” in this specification refers to the dimethyl ether of the anhydrous isomer of sorbitol. It is a transparent, slightly oily liquid and, because it is amphiphilic, can be used as a solvent for water-soluble or fat-soluble substances, and can also be used as an antioxidant or a viscosity reducer.

[0049] The term “ethoxydiglycol (CAS No. 111-90-0)” in this specification has amphiphilic properties and can be used as a solvent for water-soluble or fat-soluble substances, and can also be used as a flavoring agent or a viscosity reducing agent.

[0050] The term “Propylene Glycol Caprylate (CAS No. 31565-12-5 or 68332-79-6)” in this specification is an ester of caprylic acid and propylene glycol. It can be used as a polar oil and can also be used as a skin softener or a surfactant (emulsifier).

[0051] The term “amphipathic” in this specification refers to a property in which hydrophobic and hydrophilic groups coexist in a single substance and have an affinity for both polar and non-polar substances.

[0052] The term “solubilization” as used in this specification refers to a phenomenon in which the solubility of a sparingly soluble substance increases, causing the liquid or solid of the sparingly soluble substance to dissolve beyond its apparent solubility limit.

[0053] The present invention relates to a cosmetic composition or a topical skin composition for enhancing the absorption of a water-soluble active ingredient into the skin. The cosmetic composition or topical skin composition according to the present invention uses an amphiphilic solvent and a highly polar oil to allow the water-soluble active ingredient to penetrate deep into the skin barrier composed of lipids. As a result, the amount of sticky ingredients remaining on the skin is reduced, so the user experience is excellent, and the activity can be excellent because the active ingredient acts deep within the skin.

[0054] Figure 1 shows the results of comparing the skin absorption capacity of a water-soluble active ingredient by an amphiphilic solvent according to one embodiment of the present invention.

[0055] Figure 2 shows the results of comparing the skin absorption capacity of a water-soluble active ingredient by an amphiphilic solvent and a polar oil according to one embodiment of the present invention.

[0056] Figure 3 shows the results of comparing stickiness caused by an amphiphilic solvent and a polar oil according to one embodiment of the present invention.

[0057] Figure 4 shows the skin brightness improvement effect of the composition according to one embodiment of the present invention.

[0058] Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings so that those skilled in the art can easily implement the present invention. Unless otherwise defined, terms used in this specification should be interpreted as generally understood by those skilled in the art.

[0059] The drawings and embodiments of this specification are intended to enable a person skilled in the art to easily understand and practice the invention. Content that may obscure the essence of the invention may be omitted from the drawings and embodiments, and the invention is not limited to the drawings and embodiments.

[0060] Throughout this specification, "%" used to indicate the concentration of a particular substance is (weight / weight)% for solid / solid, (weight / volume)% for solid / liquid, and (volume / volume)% for liquid / liquid, unless otherwise noted.

[0061]

[0062] Preparation Example: Preparation of compositions for examples and comparative examples

[0063] After weighing the water-soluble active ingredient, purified water, dimethyl isosorbide, polyol, thickener, solubilizer, and preservative, the aqueous phase was prepared by mixing for 5 minutes using a homogenizer (HOMOGENIZING MIXER MARK II Model 2.5, 147012A, PRIMIX). Additionally, after weighing the ethoxydiglycol, propylene glycol caprylylate, and solubilizer, the solubilized part was prepared by mixing for 5 minutes using a homogenizer. Then, the solubilized part prepared above was added to the aqueous phase prepared above, and the cosmetic compositions of the examples and comparative examples were prepared by mixing for 5 minutes using a homogenizer.

[0064]

[0065] Experimental Example 1: Evaluation of Skin Absorption of Water-Soluble Active Ingredients According to Amphiphilic Solvents

[0066] The skin absorption capacity of Reference Examples 1 and 2 and Comparative Example 1, prepared according to the compositions shown in Table 1 below in accordance with the above preparation example, was compared. At this time, dimethyl isosorbide and ethoxydiglycol were used as amphiphilic solvents, and niacinamide was used as a water-soluble active ingredient.

[0067] Classification Component Name Comparative Example 1 Reference Example 1 Reference Example 2 Aqueous Phase Solvent Purified Water To 100 To 100 To 100 Active Ingredient Niacinamide 444 Amphiphilic Solvent Dimethyl Isosorbide-510 Polyol Glycerin; Butylene Glycol 101010 Preservative 1,2-Hexanediol 222 Thickening Agent Sodium Polyacryloyl Dimethyl Taurate 0.30.30.3 Solubilizing Part Amphiphilic Solvent Ethoxydiglycol-11 Oil Propylene Glycol Caprylate---Solubilizing Agent Polyglyceryl-10 Laurate 0.30.30.3 Total (Weight%) 100 100 100

[0068] Specifically, the test area (inner forearm) was washed with IVORY soap and kept in a constant temperature and humidity room (22±2 ℃ to 60 % RH) for 10 minutes, after which the absorption spectrum at different skin depths was measured. Then, Reference Examples 1 and 2 and Comparative Example 1 were applied to the test area and used for 20 minutes, after which the absorption spectrum at different skin depths was measured. At this time, the measurement of the absorption spectrum at different skin depths was performed using Raman spectroscopy, and a Raman Spectroscopy instrument (HORIBA, France) was used for the measurement. The measured skin absorption power is represented as Intensity (AU) values ​​according to skin depth (μm), and is shown in Table 2 and Figure 1 below.

[0069] Skin depth (μm) Intensity (AU) Comparative Example 1 Reference Example 1 Reference Example 20 (Surface) 25.05 30.1 330.5 75 19.6 231.1 830.4 910 18.2 919.6 136.3 21 514.5 618.7 733.6 420 14.9 116.3 624.6 925 15.8 914.5 318.3 230 19.9 417.0 216.3 735 17.8 114.3 16.9 840 19.0 413.1 417.2 745 12.0 410.7 717.2 550 11.5 819.7 119.7

[0070] As a result of the measurement, Reference Example 1, which had 5 wt% of dimethyl isosorbide added, penetrated niacinamide to a depth of 5 μm in the skin, and Reference Example 2, which had 10 wt% of dimethyl isosorbide added, penetrated niacinamide to a depth of 10 μm in the skin. On the other hand, Comparative Example 1, which did not have dimethyl isosorbide added, failed to penetrate niacinamide deep into the skin, so a significant amount of niacinamide remained on the surface of the skin.

[0071]

[0072] Experimental Example 2: Evaluation of Skin Absorption of Water-Soluble Active Ingredients According to Amphiphilic Solvent and Polar Oil

[0073] The skin absorption capacity of Example 1 and Comparative Example 1, prepared according to the compositions shown in Table 3 below in accordance with the above preparation example, was compared. At this time, dimethyl isosorbide and ethoxydiglycol were used as amphiphilic solvents, propylene glycol caprylate was used as a polar oil, and niacinamide was used as a water-soluble active ingredient.

[0074] Classification | Ingredient Name | Comparative Example 1 | Example 1 Aqueous Phase Solvent | Purified Water | To 100 | To 100 Active Ingredient | Niacinamide 44 | Amphiphilic Solvent | Dimethyl Isosorbide-5 | Polyol | Glycerin; Butylene Glycol 10 | 10 Preservative | 1,2-Hexanediol 22 Thickening Agent | Sodium Polyacryloyl Dimethyl Taurate 0.3 | 0.3 Solubilizing Agent | Amphiphilic Solvent | Ethoxydiglycol-1 | Oil | Propylene Glycol Caprylate-0.2 Solubilizing Agent | Polyglyceryl-10 | Laurate 0.3 | 0.3 Total (Weight%) | 100 | 100

[0075] The experiment measured the absorption spectrum at different skin depths using Example 1 and Comparative Example 1 in the same manner as Experimental Example 1. At this time, the measurement of the absorption spectrum at different skin depths was performed using Raman spectroscopy, and a Raman Spectroscopy instrument (HORIBA, France) was used for the measurement. The measured skin absorption power was expressed as Intensity (AU) values ​​according to skin depth (μm), and is shown in Table 4 and Figure 2 below.

[0076] Skin depth (μm) Intensity (AU) Comparative Example 1 Example 10 (Surface) 25.05 19.3 25 19.6 217.6 6 10 18.29 24.25 15 14.5 6 21.8 4 20 14.9 129.1 1 25 15.8 9 27.9 9 30 19.9 4 17.2 9 35 17.8 121.7 4 40 19.0 4 37.6 4 5 12.0 4 27.5 4 5 0 11.5 8 23.39

[0077] As a result of measurement, Example 1, which contained 5 wt% dimethyl isosorbide and 0.2 wt% propylene glycol caprylate, penetrated niacinamide to a depth of 40 μm in the skin. That is, compared to Experimental Example 1, when propylene glycol caprylate is used together with dimethyl isosorbide, the skin absorption capacity of the water-soluble active ingredient is significantly enhanced compared to using dimethyl isosorbide alone.

[0078]

[0079] Experimental Example 3: Evaluation of stickiness according to dimethyl isosorbide and propylene glycol caprylate

[0080] The stickiness of Example 2 and Comparative Example 2, prepared according to the compositions shown in Table 5 below in accordance with the above preparation example, was compared. In this case, dimethyl isosorbide and ethoxydiglycol were used as amphiphilic solvents, propylene glycol caprylate was used as a polar oil, and tranexamic acid was used as a water-soluble active ingredient.

[0081] Classification Component Name Comparative Example 2 Example 2 Aqueous Phase Solvent Purified Water To 100 To 100 Active Ingredient Tranexamic Acid 10 10 Amphiphilic Solvent Dimethyl Isosorbide-4 Polyol Glycerin; Butylene Glycol; Propanediol 10 10 Preservative 1,2-Hexanediol 2 2 Solubilizing Part Amphiphilic Solvent Ethoxydiglycol-1 Oil Propylene Glycol Caprylate-0.01 Solubilizing Agent Polyglyceryl-10 Laurate 0.3 0.3 Total (Weight%) 100 100

[0082] Specifically, the test area (back of the hand, 3×3 cm) was cleaned, and equal amounts of Example 2 and Comparative Example 2 were applied to the test area, respectively, and left for 5 minutes. Then, colored paper (sprinkles) of a uniform size were placed tightly on the test area where Example 2 and Comparative Example 2 were applied, and after applying a constant pressure and gently tapping the surrounding area to make the colored paper fall off, the number of colored papers remaining attached to the test area was checked. The experimental results are shown in Figure 3 below.

[0083] As a result of the experiment, there were 12 colored papers remaining on the test area coated with Example 2, and 37 colored papers remaining on the test area coated with Comparative Example 2.

[0084] In other words, when an amphiphilic solvent and a polar oil are included along with a water-soluble active ingredient, penetration is improved, which reduces the amount of ingredients remaining on the skin surface and allows for the preparation of a composition with improved stickiness.

[0085]

[0086] Experimental Example 4: Evaluation of Skin Brightness Improvement Effect

[0087] The skin brightness improvement effect of Example 2, prepared in Experimental Example 3 according to the above manufacturing example, was compared.

[0088] Specifically, the test area (inner forearm) was washed with IVORY soap, and after waiting in a constant temperature and humidity room (22±2 ℃, 40 to 60 % RH) for 10 minutes, skin brightness was measured. Then, Experimental Example 2 was applied to the test area, and skin brightness was measured in the same manner as before application. The measurement results are shown in Fig. 4 below.

[0089] As a result of the measurement, the L value increased from 72.7 to 73.8, indicating that skin brightness was improved by 1.6% by Example 2 with just one use.

Claims

1. Water-soluble active ingredient; An amphiphilic solvent comprising one or more of dimethylisosorbide and ethoxydiglycol; and Skin absorption-enhancing cosmetic composition containing a polar oil containing propylene glycol caprylate.

2. A cosmetic composition according to claim 1, wherein the water-soluble active ingredient is one or more selected from the group consisting of niacinamide, tranexamic acid, arbutin, ascorbic acid, adenosine, and derivatives thereof.

3. A cosmetic composition according to claim 1, wherein the water-soluble active ingredient is contained in an amount of 0.00001 to 30 weight% relative to the total cosmetic composition.

4. A cosmetic composition according to claim 1, wherein the dimethyl isosorbide is included in an amount of 0.1 to 50 weight% relative to the total cosmetic composition.

5. A cosmetic composition according to claim 1, wherein the ethoxydiglycol is included in an amount of 0.1 to 10 weight% relative to the total cosmetic composition.

6. A cosmetic composition according to claim 1, wherein the propylene glycol caprylate is contained in an amount of 0.00001% to 1% by weight relative to the total cosmetic composition.

7. The cosmetic composition of claim 1, wherein the cosmetic composition further comprises one or more selected from the group consisting of moisturizers, preservatives, solubilizers, thickeners, pH adjusters, chelating agents, antioxidants, pigments, and fragrances.

8. Water-soluble active ingredient; An amphiphilic solvent comprising one or more of dimethylisosorbide and ethoxydiglycol; and A topical skin composition containing a polar oil containing propylene glycol caprylate.

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