Aromatic carboxamide compounds and methods of using thereof
Aromatic carboxamide compounds address the need for new treatments by modulating STAT6 activity, effectively treating IL-4 and IL-13 mediated conditions like atopic dermatitis and asthma.
WO2026139841A1PCT designated stage Publication Date: 2026-07-02NOVARTIS AG
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- NOVARTIS AG
- Filing Date
- 2025-12-22
- Publication Date
- 2026-07-02
AI Technical Summary
Technical Problem
There is a need for new and/or alternative treatments for IL-4 and/or IL-13 mediated diseases and/or conditions such as atopic dermatitis (AD), as existing biologic antagonists and small molecule inhibitors have limitations.
Method used
Development of aromatic carboxamide compounds that modulate or inhibit STAT6 activity, which are key drivers of type 2 immune responses in conditions like atopic dermatitis, asthma, and other inflammatory disorders.
Benefits of technology
The aromatic carboxamide compounds effectively treat conditions mediated by IL-4 and IL-13, providing therapeutic benefits for atopic dermatitis and other STAT6-dependent diseases by modulating or inhibiting STAT6 activity.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure IB2025063301_02072026_PF_FP_ABST
Abstract
The present disclosure relates to a compound of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein the variable are as defined herein. The invention further provides modulators or inhibitors of STAT6 activity, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by IL-4 and / or IL-13.
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