Steroids TRIZ Cases

An industrial SAGE-718 route replaces chiral CO2 chromatography with achiral epimer separation, cutting complexity and improving yield.

Modulating NR4A1 with triterpenoid compounds induces apoptosis and expands treatment options for cancer and other proliferative diseases.

Direct nasal delivery of isolithocholic acid derivatives bypasses gut-lung dilution to suppress airway cytokines and neutrophil influx.

Microbial phytosterol conversion improves cholesterol derivative yield and purity while avoiding animal extraction and difficult purification.

Stepwise enzymatic UDCA synthesis simplifies cofactor regeneration and reaction equilibrium control while delivering high yield and 99.75% enantiomeric purity.

Stepwise enzyme stages with tailored cofactors and reaction conditions overcome incompatibility and reversibility in high-purity ursodeoxycholic acid production.

Precipitation, recrystallization, and mild hydrolysis deliver high-purity allopregnanolone while avoiding solvent-heavy chromatography.

Stable pregnadiene intermediates and non-toxic solvents enable scalable, high-purity corticosteroid synthesis without unstable halo-diol starting materials.

Controlled reduction, acetylation, and oxidation steps help prepare cholesterol derivatives while addressing yield, purification, safety, and supply constraints.

Organic solvent nanofiltration separates vitamin D3 precursors from higher molecular species for purified feedstock and colorant recovery.

Polar protic solvents enable 6-bromo-4-en-3-one steroids to react with thioamides or thioureas, forming 3,4-thiazolo steroids without anhydrous conditions or inert atmospheres.

A halogen replaces the 11-hydroxy group to alter glucocorticoid processing while preserving anti-inflammatory activity and limiting side effects.

Adding the protected intermediate to a hot aromatic solvent limits photoreactor-depositing byproducts while preserving conversion and yield.

Cholesterol-conjugated sulfated quercetin dimers target CSCs with improved oral bioavailability.

Room-temperature phosphorylation converts insoluble budesonide into a stable, water-soluble disodium salt without harsh conditions or strong acid byproducts.

Replacing carcinogenic chromium(VI) oxide with a ruthenium catalyst system eliminates toxic waste while maintaining high oxidation yields.

One-pot synthesis bypasses unstable intermediate isolation to reduce impurities and improve product quality for industrial production.

Actinic-ray-sensitive resin composition uses compounds converting to acid groups upon exposure to enhance sensitivity and resolving power.

Crystalline intermediate isolation drives high-purity abiraterone acetate production while eliminating complex silica chromatography steps.

Recrystallizing the diethylamine salt intermediate replaces column chromatography, raising obeticholic acid yield to 32% and simplifying industrial synthesis.

New testosterone derivatives with carboxyalkyl substitution enable sensitive tracer detection in competitive immunoassays.

Solvent-free quaternization of steroid precursors with 3-bromopropene minimizes genotoxic residue and shortens reaction time.

A cholic acid preparation method uses oxidation and ethylene attachment to achieve high yields.

Molecular oxygen mediates copper halide catalysis to resolve the contradiction between reaction completion and excessive copper waste in steroid production.

Cholate photoacid generators enable sub-quarter micron resolution by improving solubility and imaging effectiveness in photoresist compositions.

Replacing methanol with isopropyl ether maintains 44-51% epimer A while achieving over 90% purity.

Segmented synthesis replaces hazardous chromium oxidants with pyridinium tribromide to improve product purity and scalability.

A segmented chemical synthesis process for bile acid derivatives employs Grignard reactions and oxidative cleavage to form complex molecular structures.

Covalently attached azobenzene units allow glassy polymers to fix shapes with 442 nm light, solving lengthy UV exposure and limited fixity issues.

Safe manufacturing of epimerically pure ciclesonide avoids explosive perchloric acid hazards while maintaining high yield.

A resist composition uses a specific acid generator to change solubility upon exposure.

Adjusting pH to 8-9.5 during lyophilization prevents hydrolysis, reducing residual 3-bromopropylene while maintaining product stability.

Merging protection and activation steps reduces synthesis complexity while improving product purity.

Novel berberine and ursodeoxycholic acid salt compositions target multiple metabolic pathways simultaneously.

Pyridyl analogs of CDDO-Im modulate nitric oxide production while achieving higher plasma stability in human blood.

Integrated copper-chelating ligands stabilize the Cu(I) oxidation state to accelerate click chemistry while eliminating cell toxicity from external chelators.

A chenodeoxycholic acid purification process uses a mixed ethyl acetate and hexane solvent system to enhance yield and purity.

Small molecule compounds bind to the EGFR kinase domain to stabilize its active conformation and enhance traditional TKI affinity.

Alkali metal alcoholates mediate prasterone triflation to prevent genotoxic impurity formation, eliminating chromatographic purification steps.

Replacing chemical oxidants with galvanostat-controlled electrocatalytic oxidation eliminates peroxidation side reactions and boosts product yield.

Halogenated tetracyclic triterpene derivatives resolve low bioavailability by improving solubility and metabolic stability via structural modification.

Iodine catalyzes cyclic ketal deprotection to produce brexanolone with minimal epimerization, avoiding chromatographic purification.

A one-pot process converts chenodeoxycholic acid derivatives into high-purity obeticholic acid salts using sequential catalytic hydrogenation and metal hydride reduction.

Methanol extraction and silica gel chromatography isolate uttroside B and A from Solanum nigrum, eliminating preparative HPLC to reduce cost.

Direct oxidation replaces complex multi-step sequences that lower yield and require debromination, maintaining optical activity.

Replacing ethyl chloroformate with pivaloyl chloride resolves yield and purity contradictions in glycocholic acid synthesis.

Narrow bandwidth light converts onapristone intermediates, raising yield to 95% while eliminating complex separation steps.