Method for preparing high-purity sulfonamide compound, and intermediate of sulfonamide compound
Patent Information
- Application Number
- CN201580075876.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2015-03-10
- Publication Date
- 2017-11-28
- Estimated Expiration
- 2035-03-10
AI Technical Summary
It is difficult to effectively prepare high-purity sulfonamide compounds with existing technology, especially due to their low solubility in conventional solvents and difficulty in purification, resulting in low product purity. Similar chemical and physical properties make other new herbicides also have similar technical difficulties. .
By converting crude sulfonamide compounds into intermediates that are easily soluble in conventional solvents, hydrolysis is performed to obtain high-purity sulfonamide compounds, and specific reaction conditions and catalysts are used to improve the purity of the product, including reacting with solvents, bases or acids under the action of solvents, bases or acids. For the reaction of specific compounds, 4-dimethylaminopyridine is used as a catalyst, the reaction temperature is controlled between -10°C and 80°C, and the reaction is monitored by HPLC to complete.
The preparation of high-purity sulfonamide compounds is achieved. The HPLC purity reaches more than 99.9%. The operation is simple and the yield is high. It is suitable for the scientific research and production of sulfonamide drugs and overcomes the problems of low solubility and difficult purification.