Composition for treating hypothyroidism

Abstract

The present invention discloses a composition for treating hypothyroidism. The formula includes: placenta, antler, Pseudostellaria baicalensis, Salvia miltiorrhiza, and Herba Lycopodii. The prescription of the present invention is demonstrated to have therapeutic effects on hypothyroidism from both traditional Chinese medicine and modern medicine perspectives: from the perspective of traditional Chinese medicine, the efficacy of the present invention in replenishing qi and blood, regulating yin and yang, tonifying kidney essence, filling the marrow sea, and unblocking meridians is unique in treating goiter. From the perspective of modern medicine: Panlushending Jiawei Decoction has the effects of promoting cell reproduction, differentiation, and repairing damaged cells, and is also anti-apoptotic. It also has the effects of promoting the regeneration of vascular endothelial cells, forming new blood vessels, increasing blood flow rate, increasing blood supply, and increasing the secretion and synthesis of thyroid hormones. It can also increase the level of free hormone reabsorption from the intestine and lower the concentration of antibodies.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and particularly to a composition for treating hypothyroidism. Background Art

[0002] Hypothyroidism, abbreviated as HT, is a disease caused by decreased synthesis and secretion of thyroid hormones or insufficient physiological effects, resulting in reduced body metabolism. Its symptoms include: fear of cold, fatigue, few words, anemia, lethargy, mental decline, facial and limb swelling, loss of appetite, abdominal distension, constipation, hair loss, palpitation, shortness of breath, occasional precordial pain or pressure sensation, tinnitus, hearing loss, etc.

[0003] Traditional Chinese medicine has no clear disease name for hypothyroidism. In the past, it was mostly determined based on its clinical main symptoms and was called consumptive fatigue, edema, five retardations, coma, etc. Modern medical experts aim to standardize the traditional Chinese medicine disease name of hypothyroidism and conduct a series of discussions on it, calling it goiter consumptive fatigue, goiter deficiency disease or consumptive goiter. The pathogenic factors of goiter deficiency disease (HT) are diverse, but generally speaking, it is mainly due to the deficiency of the congenital foundation inherited and the improper care in the later-day recuperation and treatment. "Supplementary and Revised Guide to Physicians' Palm: Deficiency and Consumption" states: "The consumptive fatigue of children is caused by the mother's womb." Congenital hypothyroidism has a great relationship with the diet of the mother during pregnancy and the environment (exposure to strong radiation). Most of the acquired hypothyroidism is caused by iatrogenic damage such as surgery, 131I and drug treatment when suffering from goiter tumor or goiter disease (hyperthyroidism), which can cause damage to the qi and blood, yin and yang, essence and fluid, and marrow of the body, and the viscera are not nourished, thus resulting in this disease.

[0004] Primary hypothyroidism has a great relationship with the mother eating less iodine-containing foods or taking too much iodine-rich drugs during pregnancy or working and living in an environment with excessive radiation. Most of the secondary hypothyroidism is caused by directly removing part of the thyroid tissue after surgery for hyperthyroidism, or destroying thyroid cells with 131I treatment. There are also some patients who take anti-hyperthyroidism drugs to treat hyperthyroidism and cause hypothyroidism. The symptoms and signs of hypothyroidism caused by drug treatment can gradually减轻 after stopping the drug. For the first two types of hypothyroidism, patients with partial thyroid resection or damaged thyroid cells almost need to take thyroid hormones for life, and with the passage of time, the amount of hormones taken continuously increases, resulting in varying degrees of side effects in patients.

[0005] Currently, the treatment with simple traditional Chinese medicine prescriptions only relieves symptoms and signs stage by stage, and the efficacy stability time is short. It often needs to be配合 with western medicine thyroid hormone treatment to have obvious effects. Western medicine uses thyroid hormone replacement treatment, which can improve laboratory indicators, but the relief of clinical symptoms is poor, and it cannot fundamentally change the lesions of the thyroid itself. It needs to be taken for life, and during the treatment process, especially in elderly patients, serious side effects such as tachycardia, arrhythmia, angina pectoris, and heart failure may occur. Summary of the Invention

[0006] In view of the problems existing in the above-mentioned prior art, the present invention provides a composition for treating hypothyroidism, which can effectively inhibit thyroid cell reduction, atrophy, damage, etc.

[0007] The purpose of the present invention is achieved through the following technical solutions:

[0008] A composition for treating hypothyroidism comprises components of placenta, cervus antler, Pseudostellaria heterophylla, Salvia miltiorrhiza and Herba Cyperi.

[0009] Preferably, the components are calculated in parts by mass:

[0010]

[0011]

[0012] The present prescription demonstrates its therapeutic efficacy for hypothyroidism from both traditional Chinese medicine and modern medicine perspectives. From a traditional Chinese medicine perspective, placenta and deer antler nourish kidney essence, warm yang, and fill the marrow sea, resulting in robust kidney essence. Deer antler and placenta, combined with their mild medicinal properties, are pure tonics without damaging, treating various deficiencies and achieving a combined replenishing effect. Salvia miltiorrhiza activates blood circulation and unclogs the meridians, opening the extraordinary meridians. Pseudostellaria chinensis replenishes qi, promotes fluid production, and strengthens the spleen. These two ginsengs share the effects of dredging the meridians, promoting fluid production, regenerating muscle, and replenishing new blood. Meanwhile, the cold nature of gentiana scabra prevents the various discomforts caused by excessive warmth from these herbs. Therefore, the present invention's efficacy in tonifying qi and blood, regulating yin and yang, tonifying kidney essence, filling the marrow sea, and unblocking the meridians is unique in its efficacy in treating goiter deficiency.

[0013] From the perspective of modern medicine: Panlu Shending Jiawei Decoction has the effect of promoting cell reproduction, differentiation and repairing damaged cells, and is also anti-apoptotic. It also has the effect of promoting the regeneration of vascular endothelial cells, forming new blood vessels, increasing blood flow rate, increasing blood supply, and increasing the secretion and synthesis of thyroid hormones. It can also increase the level of free hormone reabsorption from the intestine and lower the concentration of antibodies. DETAILED DESCRIPTION

[0014] The following specific examples further illustrate the present invention so that those skilled in the art can better understand the present invention and implement it, but the examples are not intended to limit the present invention. According to common technical knowledge and customary means in this field, without departing from the above-mentioned basic technical concept of the present invention, other various forms of modification, replacement or change made to the above-mentioned structure of the present invention should all fall within the scope of protection of the present invention.

[0015] Common causes of hypothyroidism after treatment of hyperthyroidism include the following:

[0016] 1. Thyroid cell reduction, atrophy or damage

[0017] The human thyroid gland is the organ that synthesizes and secretes thyroid hormones. When it is larger than normal, the amount of hormone secreted increases, indicating hyperthyroidism. Conversely, when it is too small, it indicates hypothyroidism. When patients with hyperthyroidism use antithyroid drugs or iodine-131 to treat hyperthyroidism, this can cause thyroid cell atrophy or damage. Surgical removal of part of the thyroid gland can also reduce its size and cells, leading to decreased function and reduced thyroid hormone secretion and synthesis, resulting in hypothyroidism.

[0018] 2. The blood vessels in the thyroid gland are sparsely distributed, the blood flow rate is reduced, and the blood supply is insufficient.

[0019] For the thyroid gland to synthesize and secrete thyroid hormones normally, it needs normal vascular distribution, blood flow rate, and blood supply. If the vascular distribution is sparse, the blood flow rate is reduced, and the blood supply to the thyroid vessels is insufficient, the synthesis and secretion of thyroid hormones will be too low, resulting in hypothyroidism. If the blood supply to the thyroid vessels is increased, angiogenesis will be promoted first. Angiogenesis requires the proliferation of endothelial cells. Endothelial cell generation is related to many factors, but is most closely related to the proliferation of endothelial progenitor cells and the action of vascular endothelial growth factor (VEGF). The links between these two factors promoting angiogenesis are:

[0020] 2.1 Endothelial progenitor cells (EPCs): These cells originate from the bone marrow, umbilical cord, and peripheral blood. They are the precursors of endothelial cells and gradually migrate, proliferate, and differentiate in the circulation, ultimately forming mature endothelial cell types. Yu Zhangping's research has found that EPCs can be mobilized through the bloodstream when the body is damaged or stimulated. Late-stage EPCs possess strong proliferation, migration, and differentiation abilities, allowing them to directly enter damaged tissues to repair the tubular endothelium and form new capillaries.

[0021] 2.2 Vascular endothelial growth factor (VEGF): It has long been considered an important factor in promoting thyroid angiogenesis. Research by Xiong Yan et al. has shown that VEGF expression levels are relatively low in thyroid tissue with functional decline. Experimental results by Liu Qingyang et al. have shown that there is a positive correlation between thyroid volume and serum VEGF levels. The higher the serum VEGF level, the more obvious the thyroid enlargement. The VEGF family consists of VE-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor. They play a role in angiogenesis by activating the tyrosine kinase receptors VEGFR-1, VEGFR-2, and VEGFR-3.

[0022] 3. Insufficient intestinal reabsorption of free hormones

[0023] Free thyroid hormone is the main part of realizing the biological effect of the hormone, including T3 (triiodothyronine), T4 (total thyroxine), FT3 (free triiodothyronine), FT4 (free thyroxine), and TSH (thyrotropin). After the thyroid hormone enters the cells and is utilized by the tissues, it is deiodinated and inactivated in the tissues. Some thyroid hormones are combined with glucuronic acid or sulfate in the liver and enter the intestines through bile. Some of the combined bodies are broken down by intestinal bacteria (Bibacterium, Lactobacillus, Escherichia coli, etc.) and release free hormones, which are reabsorbed by the intestines, forming an enterohepatic circulation. Since HT patients often have hard or dry stools, the reason is that there are few beneficial bacteria in the intestines, resulting in low levels of decomposition, release and reabsorption of free hormones. Therefore, the more beneficial bacteria in the intestines, the greater the amount of glucuronic acid or sulfate combined bodies broken down and released as free hormones, the more free hormones are reabsorbed into the blood, and more free hormones are available in the body, which can relieve or alleviate the symptoms and signs of hypothyroidism.

[0024] In addition to hypothyroidism caused by hyperthyroidism after treatment, there is also hypothyroidism caused by autoimmune damage, various thyroid inflammations, amiodarone and other reasons.

[0025] Although traditional Chinese medicine has achieved certain results in the treatment of hypothyroidism, due to limited conditions, the understanding of the etiology and pathogenesis of hypothyroidism is not deep and detailed enough, and the medication does not target the main etiology and pathology of hypothyroidism. The treatment needs to be combined with Western medicine thyroid hormones to be effective. Treatment with simple Chinese medicine prescriptions can only relieve symptoms and signs, and does not fundamentally solve the defects of thyroid cell reduction, atrophy or damage, insufficient blood supply to the thyroid gland resulting in too little secretion and synthesis of hormones, or insufficient reabsorption of free hormones in the intestine.

[0026] Modern medicine mostly uses exogenous thyroid hormone replacement therapy. Although it can improve laboratory indicators, it is not effective in relieving clinical symptoms, and there are problems in the accuracy of replacement dosage and reducing antibody titers. It cannot fundamentally change the pathological changes of the thyroid itself, and often requires lifelong replacement therapy. Moreover, during the treatment process, the dosage of thyroid hormone is gradually increased, and the side effects of the drug are aggravated accordingly. In particular, elderly patients may experience serious side effects such as tachycardia, arrhythmia, angina pectoris, and heart failure. Some patients may develop goiter after taking the drug for a long time, while thyroid function (low T3, T4, FT3, FT4, high TSH) is reduced. The complexity of the disease increases the difficulty of treatment. In addition, it may also cause anemia, fatigue, facial edema, enlarged uterus leading to functional uterine bleeding, enlarged prostate, increased blood pressure, increased blood viscosity and other treatment contradictions.

[0027] 1. Composition and usage

[0028] Ingredients: Placenta powder (Placenta), antler slices, Pseudostellaria baicalensis, Salvia miltiorrhiza, and Herba Cyperi chinensis g.

[0029] Usage: Steam the placenta powder according to the proportion (or disinfect it); add appropriate amount of water (water should be 1.5cm above the surface of the medicine) to deer antler slices (crushed), Salvia miltiorrhiza, Pseudostellaria baicalensis, and Plantago asiatica and boil the medicine twice, each time for about 55 minutes. Mix the liquid medicine with the placenta powder and take it orally, one dose per day, divided into three times.

[0030] Since each patient's condition is not the same and may change at any time, the amount of each ingredient in each dose of Pan Lu Shen Ding Jia Wei Tang needs to be confirmed again, but it needs to be ensured that it is within this content range.

[0031] 2. Pharmacology

[0032] From the perspective of traditional Chinese medicine:

[0033] 1. Placenta: Compendium of Materia Medica calls human placenta "placenta", which is "sweet, salty and warm in nature" and enters the lung, heart and kidney meridians. It has the effects of "calming the mind, nourishing blood, replenishing qi, replenishing kidney, benefiting essence, detoxifying and replenishing blood". It has miraculous effects on "those who are tired, emaciated and weak". "Those who take it for a long time will have sharp ears and eyes, black hair and beard, and prolong their lifespan. It has the power to surpass nature." "Supplement to Materia Medica" records that it "is used to treat thinness of qi and blood, strain in women, dark complexion and skin, and those who gradually become thin and emaciated due to various abdominal diseases." It can replenish qi and blood, regulate yin and yang, benefit kidney essence and fill the marrow sea, and has extremely comprehensive effects.

[0034] 2. Deer antler: First mentioned in Shennong's Herbal Classic, it refers to the ossified antlers of red deer (Cervus elaphus Linnaeus) and sika deer (Cervus nippon Temminck), or the antler bases shed in the spring of the following year after velvet sawing. Deer antler is warm in nature, salty in flavor, and enters the liver and kidney meridians. It has the effects of warming the kidneys and tonifying deficiency, strengthening tendons and bones, and promoting blood circulation. It is used to treat kidney yang deficiency, impotence and spermatorrhea, low back pain, genital ulcers, early-stage mastitis, and hemorrhoidal bleeding.

[0035] 3. Salvia miltiorrhiza: Bitter, slightly cold, it clears the heart and cools the blood, and is used to treat blood-heat rash. The Rihuazi Materia Medica states that it can "nourish the mind and calm the spirit, open the meridians... discharge pus and relieve pain, promote muscle growth, and replenish new blood." Therefore, Salvia miltiorrhiza is often used in tonic prescriptions to treat deficiency-related diseases.

[0036] 4. Pseudostellariae: It has the effects of invigorating Qi and strengthening the spleen, promoting fluid production and moistening the lungs. It is mainly used to treat spleen deficiency, fatigue, loss of appetite, weakness after illness, Qi and Yin deficiency, spontaneous sweating and thirst, and dry cough caused by dry lungs.

[0037] 5. Viola yedoensis: It is cold in nature and slightly bitter in taste. It has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling.

[0038] Chemical composition and pharmacological effects:

[0039] 1. The chemical composition of placenta is relatively complex, and its pharmacological effects mainly include the following five aspects:

[0040] Hormones: Placenta contains a large amount of hormones, mainly estrogen, including human chorionic gonadotropin (HCG), adrenocorticotropic hormone-releasing hormone (GnRH), adrenocorticotropic hormone-releasing hormone (GRH), estradiol, estrone, etc.

[0041] Cytokines, including interferon (IFN-β), colony stimulating factor-1 (CSF-1), human placental immunomodulatory factor (HPIF, also known as placental peptide PIP), epidermal growth factor (EGF), transforming growth factor-β (TGF-β), etc.

[0042] Enzymes and enzyme inhibitors, including membrane matrix metalloproteinases, Kunit-type proteinase inhibitors, sialolysinogen activating factor, histaminease, etc.

[0043] Amino acids: Human placenta contains a total of 17 amino acids, among which Ala has the highest content, accounting for 18.8% of the total amino acids, and 7 essential amino acids, accounting for about 35.7% of the total amino acids.

[0044] Human placenta contains trace amounts of vitamin B12, acetylcholine, immunoglobulin G, etc. Placenta powder preparation can significantly increase the phagocytic index of mouse monocytes and macrophages, increase the weight of immune organs, and has a strong promoting effect on the transformation reaction of mouse spleen lymphocytes.

[0045] 2. Deer antlers: Their chemical composition mainly contains animal hormones, a variety of amino acids, peptides, sugars and a small amount of trace elements.

[0046] Deer antlers contain trace amounts of testosterone, progesterone, pituitary prolactin, and estradiol. Low levels of LH (luteinizing hormone) and T (testosterone) in plasma, or high levels of PRL (prolactin), in male sexual function can be linked to decreased sexual function. Studies have shown that water-purified deer antler peptides can significantly increase the levels of luteinizing hormone (LH) and testosterone (T) in male rat plasma and pituitary cell culture fluid, while also significantly increasing the levels of testosterone (T) in male rat plasma and reducing the levels of prolactin (PRL) in female rat plasma and pituitary cell culture fluid. The mechanism of action may be that deer antler peptides can directly act on pituitary cells to promote the release of LH and T, while inhibiting the release of PRL.

[0047] Amino acids. Deer antlers and antler discs are rich in amino acids. Zhang Dechang et al. found that red deer antlers contain 17 kinds of amino acids, with a total content of 36.44%, and the total amount of essential amino acids is 8.51%, which has a protective effect on the gastric mucosa.

[0048] Horn glue increases bone calcium, bone phosphorus, and serum BGP levels in ovariectomized rats, widens and enlarges trabecular bone, stimulates bone formation, and increases NO concentration to prevent and treat osteoporosis. Wei Li suggests that red deer antler significantly promotes the proliferation and differentiation of mouse embryonic osteoblasts MC3T3-E1. Its anti-osteoporosis effects are not only mediated through the OPG / RANKL / RANK signaling pathway, but may also affect other cellular signaling pathways.

[0049] Trace elements and other organic substances Red deer antlers contain 18 kinds of trace elements, among which calcium, magnesium and phosphorus are very high. They are also rich in essential trace elements such as iron, copper, zinc and manganese.

[0050] The pallet protein PSAB in red deer antlers can significantly enhance the body's anti-fatigue effect and improve adrenal function. It has a significant protective effect on paint-stressed mice and can significantly increase the red blood cell count and hemoglobin content in mice.

[0051] 3. Pseudostellaria heterophylla: Contains organic acid compounds such as apigenin, as well as flavonoids such as quercetin, hyperoside, salvianolic acid, and rutin. Liu Lusong et al. conducted experiments showing that salvianolic acid can promote the proliferation, autodifferentiation, and paradifferentiation of endothelial progenitor cells.

[0052] 4. Danshen: It promotes cell repair and regeneration and also has anti-apoptotic properties. Danshensu can inhibit OX-LDL-induced apoptosis in mouse endothelial cells by inhibiting the MAPKs signaling pathway. The development of atherosclerosis involves multiple pathological changes, including endothelial damage, oxidative stress, and immune deficiency. Danshensu can inhibit endothelial cell apoptosis and has antioxidant properties, inhibiting the formation of OX-LDL and reducing OX-LDL damage to endothelial cells.

[0053] Danshensu can antagonize the apoptosis of osteoblasts in osteoporotic rats. Its mechanism of action may be to upregulate the expression levels of Bax protein and cleavedcaspase3 protein, downregulate the expression levels of Bcl-2 protein and total caspase3 protein, activate the PI3k / Akt pathway, thereby reducing the apoptosis of osteoblasts and exerting an anti-osteoporosis effect.

[0054] 5. Viola yedoensis: It contains trace elements such as Ca, Na, K, Mg, Cu, Fe, Mn, Zn, Si, and P.

[0055] It can promote epithelial cell repair and cell division. Viola yedoensis is rich in trace elements such as Cu, Fe, Mn, Zn, Mg, etc., which have effects on the activity of various enzymes in the human body, and have direct or indirect effects on the synthesis of nucleic acid proteins, immune processes, and cell reproduction. It can promote epithelial cell repair, increase cell division, increase T cells, and increase activity, thereby regulating the immune function of the organism, and regulating and controlling the body's metabolism through the enzyme system.

[0056] It can inhibit the proliferation of B lymphocytes and downregulate antibody production. Zhao Hong et al. explored the immune regulatory function of Viola yedoensis. The results showed that the water decoction of Viola yedoensis inhibited the proliferation of B lymphocytes induced by LPS in mice and downregulated the production of antibodies, but had no obvious effect on the cellular immune function of mice.

[0057] 3. Clinical Experimental Research

[0058] When patients suffer from hypothyroidism, their thyroid cells are reduced or atrophied and damaged. The present invention has the pharmacological effects of promoting the differentiation and proliferation of hypothyroid thyroid cells and repairing damaged thyroid cells. After clinical treatment of hypothyroidism, its symptoms and signs disappear.

[0059] In patients with hypothyroidism, the blood vessels in the thyroid gland are sparsely distributed and the blood flow velocity decreases. The efficacy of the present invention can increase the blood vessel density in the thyroid gland or restore it to normal levels, and the blood flow velocity can also return to normal or increase the blood flow velocity. Panlushending Jiawei Decoction can treat hypothyroidism and increase or restore abnormal thyroid function indicators T3, T4, FT3, and FT4, and reduce or mostly restore TSH to normal.

[0060] Some patients with hypothyroidism have too high peroxidase antibody concentrations. Panlu Shending Jiawei Decoction can reduce the peroxidase antibody concentration or restore it to normal levels.

[0061] Four: Analysis

[0062] 1Traditional efficacy

[0063] From the above discussion, it can be seen that most cases of acquired hypothyroidism are treated with surgery, 131 iodine and drugs when suffering from goiter or goiter (hyperthyroidism). Iatrogenic damage can cause damage to the body's qi, blood, yin and yang, essence, fluid and marrow, and malnutrition of the internal organs leading to this disease. Treatment requires prescriptions and medicines that regulate qi, blood, yin and yang, essence, fluid and marrow to be effective.

[0064] The placenta and deer antler in this invention's formula nourish kidney essence, warm yang, and fill the marrow sea, resulting in robust kidney essence, an abundant blood sea, and a full marrow sea. Deer antler and placenta, a living, symbiotic plant, greatly replenish yin essence and yang qi. Deer antler warms the body's yang qi. Together, these two herbs replenish qi and blood, regulate yin and yang, benefit kidney essence, fill the marrow sea, and unclog the meridians. Their mild properties, pure tonic without damaging, treat various deficiencies and achieve a synergistic, restorative effect. Salvia miltiorrhiza activates blood circulation and unclogs the meridians, opening the extraordinary meridians. Pseudostellaria pseudoginseng invigorates qi, promotes fluid production, and strengthens the spleen. Together, these two herbs promote unclogged meridians, promotes muscle growth, and replenishes new blood. The cooling properties of syringa chinensis prevent excessive warmth and discomfort.

[0065] Therefore, the invention has unique efficacy in treating goiter with the effects of replenishing qi and blood, regulating yin and yang, benefiting kidney essence, filling marrow sea and unblocking meridians.

[0066] 2 Modern pharmacological analysis

[0067] Panlushending Decoction promotes cell reproduction, differentiation, and repair of damaged cells. It also resists cell apoptosis and promotes the regeneration of endothelial cells, forming new blood vessels, increasing blood flow, increasing blood supply, and increasing the secretion and synthesis of thyroid hormones. It can also increase the level of free hormone reabsorption from the intestine and reduce the concentration of antibodies. The specific pharmacological effects are as follows:

[0068] 2.1 Promote cell differentiation and proliferation, and repair damaged thyroid cells

[0069] The epidermal growth factor (EGF) in the placenta is similar to the vascular endothelial growth factor (VEGF). The expression level of VEGF is relatively low in thyroid tissue with functional decline. There is a positive correlation between thyroid volume and serum VEGF level. The higher the serum VEGF level, the more obvious the thyroid enlargement. The effect of EGF may increase the volume of the thyroid gland; and colony stimulating factor-1 (CSF-1) can stimulate the proliferation and differentiation of multipotent hematopoietic stem cells and hematopoietic stem cells at different developmental and differentiation stages.

[0070] The trace elements such as Cu, Fe, Mn, Zn, Mg in Viola yedoensis have effects on the activity of various enzymes in the human body, and have direct or indirect effects on the synthesis of nucleic acid proteins, immune processes, and cell reproduction. They can promote epithelial cell repair, increase cell division, increase T cells, and increase activity.

[0071] Red deer antler has a significant effect on promoting the proliferation and differentiation of mouse embryonic osteoblasts MC3T3-E1.

[0072] The trace elements and red deer antlers in the above ingredients can promote cell differentiation and proliferation, and EGF has the effect of increasing the volume of the thyroid gland. It is speculated that these substances may cause the atrophied thyroid cells to proliferate or repair damaged thyroid cells, play the role of normal secretion and synthesis of hormones, thereby restoring the function of thyroid tissue to normal or mostly restoring to normal levels.

[0073] 2.2 Increase the formation of new blood vessels and improve blood supply

[0074] The main reasons for the decrease in thyroid hormone secretion and synthesis are the sparse distribution of blood vessels in the thyroid gland, slow blood flow and insufficient blood supply. If the blood supply to the thyroid gland is increased, the generation of new blood vessels needs to be increased. Endothelial progenitor cells are the precursors of endothelial cells. Studies have shown that estrogen can promote the proliferation of endothelial progenitor cells. The principle is that estrogen can promote the proliferation and migration of endothelial progenitor cells through the MAPK pathway. Experiments have shown that Chinese medicine for invigorating the kidneys and promoting blood circulation can promote the mobilization of endothelial progenitor cells from the bone marrow to the blood circulation by activating the MMP-9 signaling pathway.

[0075] The placenta and deer antlers in Panlu Shending Jiawei Decoction both contain estrogen, with the amount of estrogen in the placenta being more obvious. Deer antlers contain trace amounts of testosterone. Deer antler polypeptides can significantly increase the LH content in the plasma and pituitary cell culture fluid of male rats, and can also significantly increase the T content in the plasma of male rats. The placenta and deer antlers nourish the kidney and replenish essence, and Danshen promotes blood circulation. Panlu Shending Jiawei Decoction is a kidney-tonifying and blood-activating prescription.

[0076] It can be seen that the combined effects of the estrogen and androgen and the kidney-tonifying and blood-activating drugs of the present invention promote the generation and proliferation of endothelial progenitor cells, induce the thyroid endothelial cells to form new blood vessels, improve the blood supply level, and subsequently increase the secretion and synthesis levels of thyroid hormones.

[0077] 2.3 Anti-apoptotic effect

[0078] Studies have found that tanshinone can inhibit the formation of OX-LDL, reduce the damage of OX-LDL to vascular endothelial cells, and inhibit the apoptosis of vascular endothelial cells.

[0079] 2.4 Increase the reabsorption rate of intestinal free hormones

[0080] The more beneficial bacteria there are in the intestines, the greater the amount of free hormones that are decomposed and released. The placenta, deer antlers, and plantains contain more than 20 kinds of amino acids and multiple enzymes. These nutrients are the culture medium for beneficial bacteria in the intestines, which promote the increase in the number of beneficial bacteria in the intestines, causing the glucuronic acid or sulfate complexes in the intestines to be decomposed and the amount of free hormones released. Subsequently, the amount of free hormones reabsorbed back into the blood increases, significantly improving the reuse rate of free thyroid hormones.

[0081] 2.5 Downregulation of anti-peroxidase antibodies (A-TPO)

[0082] Some patients with hypothyroidism have very high concentrations of peroxidase antibodies. Viola yedoensis decoction inhibits the proliferation of B lymphocytes induced by LPS in mice, downregulates the production of antibodies, and reduces the concentration of antibodies (anti-peroxidase antibodies), thereby regulating the immune function of the organism and regulating and controlling the body's metabolism through the enzyme system.

[0083] 2.6 Treatment of symptoms, signs and complications:

[0084] Pallet protein PSAB can significantly enhance the body's anti-fatigue effect and improve adrenal function, has a significant protective effect on paint-stressed mice, and can significantly increase the red blood cell count and hemoglobin content of mice.

[0085] Trace elements have obvious auxiliary therapeutic effects on anemia. There are 18 kinds of trace elements in red deer antlers, among which the content of calcium, magnesium and phosphorus is very high. At the same time, it is rich in iron, copper, zinc, manganese, etc. Essential trace elements such as copper and iron are substances for synthesizing hemoglobin, which have the effects of strengthening the hematopoietic system and stimulating the hematopoietic function of the bone marrow. They can treat anemia and relieve symptoms such as fatigue, drowsiness, intellectual impairment, swelling of the face and limbs, palpitations, shortness of breath, tinnitus, and hearing loss.

[0086] V. Conclusion

[0087] 1. From the above analysis, we can know that Panlu Shending Jiawei Decoction has the effects of replenishing qi and blood, regulating yin and yang, benefiting kidney essence, and filling the marrow sea. It can make HT patients' qi and blood vigorous, yin and yang balanced, kidney essence abundant, and marrow sea full, so that HT disease can heal itself.

[0088] 2. From a pharmacological perspective, the growth factors, immunomodulatory factors, colony-stimulating factors, trace elements, and red deer antlers in the prescription have the ability to promote cell proliferation and differentiation, thereby increasing the volume of the thyroid gland. The combined effects of male and female hormones, various other hormones, and kidney-tonifying and blood-activating drugs promote the proliferation of endothelial progenitor cells and endothelial cells to form new blood vessels, thereby improving the blood supply level within the thyroid gland. The decoction of Viola yedoensis inhibits the proliferation of B lymphocytes and downregulates the production of antibodies.

[0089] Example 1

[0090] The mass calculation includes the components:

[0091]

[0092] Usage: Steam the placenta powder according to the proportion; add water to the antler slices, salvia miltiorrhiza, Pseudostellaria heterophylla, and phyllanthus chinensis to soak the medicine surface for 1.5cm, boil the medicine twice, each time for about 55 minutes, mix the medicine liquid with the above placenta powder and take it orally, one dose per day, divided into three times.

[0093] Example 2

[0094] The mass calculation includes the components:

[0095]

[0096] Usage: Steam the placenta powder according to the proportion; add water to the antler slices, salvia miltiorrhiza, Pseudostellaria heterophylla, and phyllanthus chinensis to soak the medicine surface for 1.5cm, boil the medicine twice, each time for about 55 minutes, mix the medicine liquid with the above placenta powder and take it orally, one dose per day, divided into three times.

[0097] Example 3

[0098] The mass calculation includes the components:

[0099]

[0100] Usage: Steam the placenta powder according to the proportion; add water to the antler slices, salvia miltiorrhiza, Pseudostellaria heterophylla, and phyllanthus chinensis to soak the medicine surface for 1.5cm, boil the medicine twice, each time for about 55 minutes, mix the medicine liquid with the above placenta powder and take it orally, one dose per day, divided into three times.

[0101] Example 4

[0102] The mass calculation includes the components:

[0103]

[0104] Usage: Steam the placenta powder according to the proportion; add water to the antler slices, salvia miltiorrhiza, Pseudostellaria heterophylla, and phyllanthus chinensis to soak the medicine surface for 1.5cm, boil the medicine twice, each time for about 55 minutes, mix the medicine liquid with the above placenta powder and take it orally, one dose per day, divided into three times.

[0105] Example 5

[0106] The mass calculation includes the components:

[0107]

[0108] Usage: Steam the placenta powder according to the proportion; add water to the antler slices, salvia miltiorrhiza, Pseudostellaria heterophylla, and phyllanthus chinensis to soak the medicine surface for 1.5cm, boil the medicine twice, each time for about 55 minutes, mix the medicine liquid with the above placenta powder and take it orally, one dose per day, divided into three times.

[0109] Case introduction: Treatment was carried out using the prescription of Example 1.

[0110] (1) Case Overview

[0111] 1 Case selection

[0112] The cases selected in the present invention are mainly hypothyroidism cases with a history of conventional treatment with anti-hyperthyroidism Western medicine, 131 iodine and surgical removal of part of the thyroid gland, without other complications, and without a history of treatment with anti-hypothyroidism Western medicine levothyroxine tablets (if used, the time was short and the dosage was small).

[0113] 2 courses of treatment: This prescription is used to treat hypothyroidism cases, and one course of treatment is every 2 months. The course of treatment for each patient is different. Patients with mild symptoms (no other complications, only a history of using Western anti-hyperthyroidism drugs, no history of using 131 iodine agents and surgery, etc.) require 2-3 courses of treatment; moderate patients (no other complications, only a history of using Western anti-hyperthyroidism drugs, no history of using 131 iodine agents and surgery, etc., or a history of using 131 iodine agents or surgery, etc.) require 4-6 courses of treatment; severe patients (with a history of using 131 iodine agents or surgery, etc.) require 7-12 courses of treatment.

[0114] 3 Treatment process and efficacy evaluation:

[0115] The process of treating hypothyroidism cases according to the present invention is divided into three stages

[0116] After 2-3 courses of treatment in the first stage: symptoms and signs of mild patients treated with the present invention (without other complications, only a history of using Western medicine for hyperthyroidism, and no history of treatment such as 131 iodine and surgery) disappear, and T4, FT4, TSH, and A-TPO basically return to normal; symptoms and signs of moderate patients treated with the present invention (without other complications, only a history of using Western medicine for hyperthyroidism, and no history of treatment such as 131 iodine and surgery) can partially disappear, with T4 and FT4 increasing, and TSH and A-TPO decreasing. Symptoms and signs of moderate patients (if they have used 131 iodine or surgery) can be largely alleviated, with T4 and FT4 increasing, and TSH and A-TPO decreasing; symptoms and signs of severe patients (with a history of treatment such as 131 iodine or surgery) can be partially alleviated, with T4, FT4, TSH, and A-TPO indicators improving. Special cases may require longer time.

[0117] In the second stage, after 4-6 courses of treatment with the present invention, symptoms and signs of mild patients (without other complications, who have used Western medicine for hyperthyroidism but have no history of treatment with 131 iodine, surgery, etc.) disappear, and T4, FT4, TSH, and A-TPO return to normal; symptoms and signs of moderate patients (without other complications, who have only used Western medicine for hyperthyroidism but have no history of treatment with 131 iodine, surgery, etc.) disappear, T4 and FT4 increase, and TSH and A-TPO decrease. Symptoms and signs of moderate patients (who have used 131 iodine or surgery, etc.) partially disappear, T4 and FT4 increase, and TSH and A-TPO decrease; symptoms and signs of severe patients (who have used 131 iodine or surgery, etc.) are alleviated, and T4, FT4, TSH, and A-TPO indicators improve. Special cases require longer time.

[0118] The third stage: After 7-12 courses of treatment with the present invention, moderate patients (without other complications, only a history of using Western medicine for hyperthyroidism, and no history of treatment such as 131 iodine and surgery) have their symptoms and signs disappear, and T4, FT4, TSH, and A-TPO indicators return to normal. Moderate patients (without other complications, but with a history of treatment such as 131 iodine and surgery) have their symptoms and signs disappear, and T4, FT4, TSH, and A-TPO basically return to normal; severe patients (without other complications, but with a history of treatment such as 131 iodine and surgery) may have their symptoms and signs disappear, with T4 and FT4 increasing and TSH and A-TPO decreasing. Special cases may require longer time.

[0119] After the symptoms and signs disappear and thyroid function returns to normal, the medication should be continued for 1-2 years. The chance of recurrence of the disease is very low.

[0120] 4. Diet and care: Eat less cold food during medication, and use heat-clearing, detoxifying, laxative, and diuretic drugs with caution.

[0121] 5Physical and laboratory examinations

[0122] Thyroid B-ultrasound, five thyroid function tests, and A-TPO are important diagnostic indicators and primary evidence for prognosis of hypothyroidism. Their normal reference values ​​are as follows:

[0123] Normal reference values ​​for thyroid B-ultrasound:

[0124] The size of the thyroid gland is approximately 30x10x10mm or larger;

[0125] The blood flow velocity of the left and right superior arteries is psv: 25 cm / s or more;

[0126] It is normal for the thyroid to have minimal vascularity;

[0127] The thickness of the isthmus is 3 mm.

[0128] Normal reference values ​​for the five thyroid function tests:

[0129] T3 (triiodothyronine) 1.1-3.1 nmo / L

[0130] T4 (total thyroxine) 66-181 nmo / L

[0131] FT3 (free triiodothyronine) 2.6-6.8pmo / L

[0132] FT4 (free thyroxine) 8-22 pmo / L

[0133] Pregnant women T1 stage 12.91-22.3pmo / L

[0134] Pregnant women T2 stage 9.81-17.26pmo / L

[0135] TSH (thyroid-stimulating hormone) 0.27-4.2 IU / L

[0136] Pregnant women in T1 stage: 0.05-5.17 IU / L

[0137] Pregnant women T2 stage 0.39-5.22IU / L

[0138] A-TPO (peroxidase antibody) 0-34 IU / ml

[0139] (II) The following are the changes in symptoms and signs of hypothyroidism patients before and after treatment, as well as the results of thyroid ultrasound, five thyroid function tests, and A-TPO examinations:

[0140] 1 Name: Chen Moumou, Gender: Female, 56 years old, from Rendong Town, Yulin City

[0141] Chief complaint: chills, fatigue, taciturnity, drowsiness, and intellectual impairment for over a year.

[0142] In 2009, he took 131 iodine to treat hyperthyroidism. After 2016, he developed chills, fatigue, sluggishness, mental retardation, loss of appetite, abdominal distension, constipation, shortness of breath, occasional pain and pressure in the precordial area, tinnitus, pale complexion, pale tongue, white and slippery tongue coating, and weak pulse.

[0143] Physical and laboratory examinations before treatment (2017)

[0144] Thyroid B-ultrasound:

[0145] The size of the thyroid gland is about 28x8x9mm.

[0146] The blood flow velocity of the left and right superior arteries is psv: 20 cm / s,

[0147] The thyroid gland is sparsely vascularized.

[0148] The thickness of the isthmus is 3 mm.

[0149] Five thyroid function tests:

[0150]

[0151]

[0152] Follow-up after 2 courses of Panlushending Jiawei Decoction:

[0153] Symptoms and signs: After two courses of treatment, the patient still had symptoms of chills, fatigue, few words, and intellectual impairment. His drowsiness, loss of appetite, abdominal distension, constipation, and shortness of breath were alleviated, and occasional precordial pain and pressure, tinnitus, and hearing loss disappeared. His tongue was pale, with a white coating, and his pulse was thin.

[0154] Thyroid B-ultrasound:

[0155] The size of the thyroid gland is about 30x8x10mm.

[0156] The blood flow velocity of the left and right superior arteries is psv: 20 cm / s,

[0157] The thyroid gland is sparsely vascularized.

[0158] The thickness of the isthmus is 3 mm.

[0159] Five A-level Merits:

[0160]

[0161] Note: After two courses of treatment, the patient only had symptoms of chills, fatigue, few words, and intellectual impairment. His drowsiness, loss of appetite, abdominal distension, constipation, shortness of breath were alleviated, and the pain or pressure in front of the heart, tinnitus, etc. disappeared. His tongue was pale with white fur and his pulse was thin.

[0162] The five items of thyroid function have improved.

[0163] Follow-up after 4 courses of Panlushending Jiawei Decoction:

[0164] Symptoms and signs: After 4 courses of treatment, the patient only had mild chills, fatigue, few words, and intellectual impairment. Other symptoms disappeared, his complexion was normal, his tongue was pale with white fur, and his pulse was thin.

[0165] Thyroid B-ultrasound:

[0166] The size of the thyroid gland is about 30x10x12mm.

[0167] The blood flow velocity of the left and right superior arteries is psv: 25cm / s,

[0168] The thyroid gland has few blood vessels.

[0169] The thickness of the isthmus is 3 mm.

[0170] Five A-level Merits:

[0171]

[0172] Note: After 4 courses of treatment, the patient still had mild chills, fatigue, few words, and intellectual impairment, but the other symptoms disappeared.

[0173] Except for TSH, all other thyroid function tests have returned to normal.

[0174] Follow-up after 8 courses of Panlushending Jiawei Decoction:

[0175] The symptoms and signs disappeared, the face became rosy, the tongue became pale red with white fur, and the pulse became thin.

[0176] Thyroid B-ultrasound:

[0177] The size of the thyroid gland is about 30x12x11mm.

[0178] The blood flow velocity of the left and right superior arteries is psv: 30cm / s,

[0179] The thyroid vascularity is normal.

[0180] The thickness of the isthmus is 3 mm.

[0181] Five A-level Merits:

[0182]

[0183] Note: After 8 courses of treatment, the patient's complexion became rosy, his tongue was light red with white fur, and his pulse was thin.

[0184] Except for TSH, which is basically normal, all other thyroid function tests have returned to normal.

[0185] The patient continued to take the medication for 1-2 years to maintain the therapeutic effect. After 2 years, his symptoms and signs had not recurred, and the five thyroid function tests were normal.

[0186] 2. Name: Kong Moumou, Gender: Male, 29 years old, from Nanjiang Town, Yulin City

[0187] Chief complaint: fear of cold, fatigue, few words, and drowsiness for more than three years, accompanied by infertility after two years of marriage.

[0188] In 2012, he took 131 iodine to treat hyperthyroidism. After 2013, he developed chills, fatigue, sluggishness, drowsiness, intellectual impairment, and loss of appetite. He did not pay attention to it at the time. He got married in 2014. Two years after marriage, his wife did not get pregnant, so he went to the hospital for treatment. Examination showed that his sperm motility was very low, the number of deformities was very high, and his thyroid function was hypoactive. He was also pale in complexion, had a pale tongue, a white and slippery tongue coating, and a weak pulse.

[0189] Physical and laboratory examinations before treatment

[0190] Thyroid B-ultrasound:

[0191] The size of the thyroid gland is about 28x10x8mm.

[0192] The blood flow velocity of the left and right superior arteries is psv: 23cm / s,

[0193] The thyroid gland is sparsely vascularized.

[0194] The thickness of the isthmus is 3 mm.

[0195] Five A-level Merits:

[0196]

[0197] Sperm routine examination: sperm survival rate 15%. Sperm static analysis: sperm deformity rate 99%, sperm normal rate 1%.

[0198] Follow-up after 2 courses of Panlushending Jiawei Decoction:

[0199] Symptoms and signs: After two courses of treatment, the patient still had symptoms of chills, fatigue, taciturnity, and intellectual impairment. His sleepiness was reduced, his appetite was normal, his tongue was pale with white fur, and his pulse was thin.

[0200] Thyroid B-ultrasound:

[0201] The size of the thyroid gland is about 30x10x8mm.

[0202] The blood flow velocity of the left and right superior arteries is psv: 25cm / s,

[0203] The thyroid blood vessels are sparsely distributed.

[0204] The thickness of the isthmus is 3 mm.

[0205] Five A-level Merits:

[0206]

[0207] Note: After two courses of treatment, the patient still had symptoms of chills, fatigue, silence, and intellectual impairment.

[0208] The five items of Jia Gong have changed.

[0209] After 4 courses of treatment with Panlushending Jiawei Decoction,

[0210] Symptoms and signs: fear of cold, fatigue, taciturnity, intellectual impairment, disappearance of drowsiness, good appetite, normal complexion, pale tongue with white fur, and thin pulse.

[0211] Thyroid B-ultrasound:

[0212] The size of the thyroid gland is about 30x12x11mm.

[0213] The blood flow velocity of the left and right superior arteries is psv: 28cm / s,

[0214] The thyroid vascularity is basically normal.

[0215] The thickness of the isthmus is 3 mm.

[0216] Five A-level Merits:

[0217]

[0218] Note: After 4 courses of treatment, the symptoms disappeared, the complexion became rosy, the tongue became light red with white fur, and the pulse became thin.

[0219] Except for TSH, which is basically normal, all other thyroid function tests have returned to normal.

[0220] Follow-up after 8 courses of Panlushending Jiawei Decoction:

[0221] The symptoms and signs disappeared, the face became rosy, the tongue became pale red with white fur, and the pulse became thin.

[0222] Thyroid B-ultrasound:

[0223] The size of the thyroid gland is about 30x12x11mm.

[0224] The blood flow velocity of the left and right superior arteries is psv: 30cm / s,

[0225] The thyroid vascularity is normal.

[0226] The thickness of the isthmus is 3 mm.

[0227] Five A-level Merits:

[0228]

[0229]

[0230] Sperm routine: sperm survival rate 60%. Sperm static analysis: sperm abnormality rate 97%, sperm normal rate 3%.

[0231] Note: After 8 courses of treatment, the patient's complexion became rosy, his tongue was light red with white fur, and his pulse was thin.

[0232] Except for TSH which was slightly elevated, all other thyroid function tests have returned to normal.

[0233] The patient continued to take the medication for 2 years to maintain the therapeutic effect. After 2 years, his symptoms and signs had not recurred, and his five thyroid function tests were normal. In 2019, his wife gave birth to two twin boys.

[0234] 3. Name: Chen Moumou, Gender: Male, 33 years old, from Mingshan Street, Yulin City

[0235] Chief complaints: chills, fatigue, taciturnity, loss of appetite, abdominal distension, and drowsiness for more than a year.

[0236] In 2010, he took 131 iodine to treat hyperthyroidism. After 2015, he developed chills, fatigue, loss of appetite, abdominal distension, drowsiness, intellectual impairment, and mild facial edema. He did not pay attention to it at the time because he could work normally. In 2016, he was preparing to get married and had a physical examination. The examination showed that he had hypothyroidism, very low sperm motility, a high number of deformities, a pale complexion, a pale tongue, a white and slippery tongue coating, and a weak and thready pulse.

[0237] Physical and laboratory examinations before treatment

[0238] Thyroid B-ultrasound:

[0239] The size of the thyroid gland is about 32x10x11mm.

[0240] The blood flow velocity of the left and right superior arteries is psv: 23cm / s,

[0241] The thyroid vascularity is good.

[0242] The thickness of the isthmus is 3 mm.

[0243] Five A-level Merits:

[0244]

[0245] Sperm routine: sperm survival rate 21%. Sperm static analysis: sperm deformity rate 99.5%, sperm normal rate 0.5%.

[0246] Follow-up after 2 courses of Panlushending Jiawei Decoction:

[0247] Symptoms and signs: After two courses of treatment, the patient still had symptoms of chills, fatigue, few words, and intellectual impairment, but no other obvious discomfort. The tongue was pale, the tongue coating was white, and the pulse was thin.

[0248] Thyroid B-ultrasound:

[0249] The size of the thyroid gland is about 32x10x12mm.

[0250] The blood flow velocity of the left and right superior arteries is psv: 30cm / s,

[0251] The thyroid vascularity is good.

[0252] The thickness of the isthmus is 3 mm.

[0253] Five A-level Merits:

[0254]

[0255]

[0256] Note: After two courses of treatment, the patient still had symptoms of chills, fatigue, silence, and intellectual impairment.

[0257] Follow-up after 4 courses of Panlushending Jiawei Decoction:

[0258] Symptoms and signs: There is still mild chills, fatigue, silence, and intellectual impairment, but other symptoms have basically disappeared.

[0259] Thyroid B-ultrasound:

[0260] The size of the thyroid gland is about 30x12x11mm.

[0261] The blood flow velocity of the left and right superior arteries is psv:32cm / s,

[0262] The thyroid vascularity is basically normal.

[0263] The thickness of the isthmus is 3 mm.

[0264] Five A-level Merits:

[0265]

[0266] Note: After 4 courses of treatment, the patient's complexion became rosy, his tongue was pale red with white fur, and his pulse was thin.

[0267] Except for TSH, which is basically normal, all other thyroid function tests have returned to normal.

[0268] Follow-up after 8 courses of Panlushending Jiawei Decoction:

[0269] The symptoms and signs disappeared, the face became rosy, the tongue became pale red with white fur, and the pulse became thin.

[0270] Thyroid B-ultrasound:

[0271] The size of the thyroid gland is about 30x12x11mm.

[0272] The blood flow velocity of the left and right superior arteries is psv:32cm / s,

[0273] The thyroid vascularity is normal.

[0274] The thickness of the isthmus is 3 mm.

[0275] Five A-level Merits:

[0276]

[0277] Sperm routine: sperm survival rate 60%, sperm static analysis: sperm deformity rate 97%, sperm normal rate 3%.

[0278] Note: After 8 courses of treatment, the patient's complexion became rosy, his tongue was light red with white fur, and his pulse was thin.

[0279] Except for a slightly elevated TSH, all other thyroid function tests have returned to normal.

[0280] The patient continued to take the medication for 1.5 years to maintain the therapeutic effect. Two years later, his symptoms and signs had not recurred, his five thyroid function tests were normal, and his wife had given birth to a baby boy.

Claims

1. A composition for treating hypothyroidism, characterized in that: The invention is composed of the following components in parts by mass: 25 parts of placenta, 10 parts of cervus antler, 25 parts of Pseudostellariae Radix, 9 parts of Salviae Miltiorrhiza and 9 parts of Viola yedoensis.

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