Formula of medicine for oral administration for treating psoriasis

Abstract

The invention provides an oral medicine formula for treating psoriasis, and relates to the field of traditional Chinese medicine formulas. The oral medicine for treating psoriasis is prepared from the following raw materials by weight: 10 g of astragalus membranaceus, 50 g of rhizoma smilacis glabrae, 10 g of salvia miltiorrhiza, 10 g of cassia twig, 10 g of cicada slough, 10 g of ligusticum wallichii, 30 g of angelica sinensis and 10 g of honey-fried licorice root. Salvia miltiorrhiza, ligusticum wallichii, angelica sinensis and other medicines have the effects of promoting blood circulation to remove blood stasis, can improve the blood circulation state of skin and promote repair of skin lesions, and have a certain curative effect on blood stasis type psoriasis patients; cassia twig and cicada slough have the effects of dispelling wind and arresting itching, can relieve the symptom of skin itch, and improve the life quality of patients; astragalus membranaceus, angelica sinensis and honey-fried licorice root have the effects of reinforcing qi and nourishing blood, can improve the overall physique of a patient, enhance the immunity of the body and contribute to disease recovery, the clinical effective rate reaches 70% or above, one treatment course lasts for three months, and the cure rate can reach 40% or above.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine formula, in particular to a formula of an oral medicine for treating psoriasis. BACKGROUND

[0002] Psoriasis, medically known as psoriasis, is a common chronic, recurrent, inflammatory skin disease, with a global prevalence of about 2%-3%, and there are certain differences between different races and regions. The disease can occur at any age, but usually between the ages of 20-30 or 50-60. The etiology of psoriasis is complex and has not been fully elucidated, but it is generally believed that it is closely related to genetic factors, immune system abnormalities, environmental factors (such as infection, trauma, drugs, and mental stress), and lifestyle habits (such as smoking and drinking).

[0003] The pathogenesis of psoriasis is closely related to the immune system, especially the functional abnormalities of T lymphocytes. The abnormal activation of T lymphocytes in the skin leads to the release of a series of inflammatory factors, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-17 (IL-17), and interleukin-23 (IL-23). These inflammatory factors stimulate the excessive proliferation and abnormal differentiation of keratinocytes, leading to the appearance of red plaques and scales on the skin, which are the typical symptoms of psoriasis. In normal skin, the process of keratinocyte proliferation and differentiation from the basal layer to the stratum corneum takes about 28 days, while in the skin of psoriasis patients, this process is significantly shortened to only 3-7 days. The excessive proliferation and abnormal differentiation of keratinocytes lead to the formation of thick scales on the skin surface, accompanied by inflammatory cell infiltration and vascular proliferation, making the skin appear red plaques.

[0004] Hormone drugs are one of the commonly used oral medicines for treating psoriasis. Although they can quickly alleviate symptoms such as skin redness and scaling, allowing the disease to be quickly controlled, their side effects cannot be ignored. Long-term use of hormone drugs in large doses can cause thinning of the skin, dilation of capillaries, and hormone dependence, among other adverse reactions. Although many oral medicines have some effect in treating psoriasis, the overall treatment effect is limited, and it is difficult to cure psoriasis fundamentally. Therefore, the present application provides a formula of an oral medicine for treating psoriasis to solve the problems raised in the background art. SUMMARY

[0005] (I) Technical problems solved

[0006] In view of the deficiencies of the prior art, the present application provides a formula of an oral medicine for treating psoriasis, which solves the problem that existing medicines contain certain hormones, which can affect the skin health of users when used for a long time, and the treatment effect is limited, making it difficult to cure psoriasis fundamentally.

[0007] (II) Technical Solution

[0008] To achieve the above object, the present application is implemented by the following technical solution: An oral medicine formula for treating psoriasis, comprising the following raw materials: Radix Astragali, Smilax Glabra, Salvia Miltiorrhiza, Ramulus Cinnamomi, Periostracum Cicadae, Ligusticum Chuanxiong, Angelica sinensis and Radix Glycyrrhizae Praeparata.

[0009] Preferably, the following weights of raw materials are used: Radix Astragali 10g, Smilax Glabra 50g, Salvia Miltiorrhiza 10g, Ramulus Cinnamomi 10g, Periostracum Cicadae 10g, Ligusticum Chuanxiong 10g, Angelica sinensis 30g and Radix Glycyrrhizae Praeparata 10g.

[0010] An oral medicine formula for treating psoriasis, comprising the following steps:

[0011] S1. Acceptance and selection of medicinal materials, strictly accept the medicinal materials, and carefully check the appearance shape, texture and odor of each medicinal material according to the Chinese Pharmacopoeia and related medicinal material standards, and remove medicinal materials that do not meet the quality requirements;

[0012] S2. Cleaning, the selected qualified medicinal materials are respectively placed in a cleaning pool and cleaned with flowing clean water, and for medicinal materials with relatively hard texture, stirring cleaning is adopted to remove the surface mud and dust;

[0013] S3. Drying, the cleaned medicinal materials are treated by manual drying, a drying machine is used for drying, the temperature is controlled at 50-60℃, and attention is paid to turning the materials to ensure uniform drying, and the moisture content of the dried medicinal materials should be controlled at 5-10%;

[0014] S4. Extraction, the water decoction extraction method is used for extraction, a corrosion-resistant and evenly heated extraction container is selected, the dried traditional Chinese medicine is placed in the prepared container, 8-10 times the weight of the medicinal material of pure water is added into the container, heated to boiling with a large fire, then changed to small fire decoction for 60 minutes, then the medicinal liquid is taken out and cooled for standby, then 6-8 times the weight of pure water is added into the container, also heated to boiling with a large fire, then changed to small fire decoction for 40 minutes, the medicinal liquid is taken out and mixed with the medicinal liquid taken out in the first time;

[0015] S5. Filtration, the two medicinal liquids in S4 are mixed and stirred uniformly, the extraction liquid is filtered with multiple layers of gauze to remove the internal dregs and impurities, and to ensure that there is no suspended matter and precipitate in the medicinal liquid;

[0016] S6. Forming of preparation, the filtered extraction liquid can be directly packaged into bags or bottled;

[0017] S7. Quality control, including but not limited to microscopic identification, chemical reaction and thin layer chromatography to identify the effective components in the traditional Chinese medicine preparation, to ensure that the preparation contains the specified traditional Chinese medicine components.

[0018] (III) Beneficial Effects

[0019] The application provides a kind of oral medicine formula for treating psoriasis.

[0020] 1、In the application, the drugs such as smilax glabra, salvia miltiorrhiza and periostracum cicada in the formula have the effects of clearing heat and resolving toxicity, which can effectively eliminate heat and dampness in the body and reduce the inflammatory response of the skin, and has good therapeutic effect on patients with blood heat type psoriasis.

[0021] 2、In the application, the drugs such as salvia miltiorrhiza, ligusticum wallichii and angelica sinensis have the effects of activating blood and resolving stasis, which can improve the blood circulation state of the skin and promote the repair of skin lesions, and have certain curative effect on patients with blood stasis type psoriasis; cassia twig and periostracum cicada have the effects of dispelling wind and relieving itching, which can relieve the symptoms of skin itching and improve the quality of life of patients; astragalus, angelica and licorice have the effects of benefiting qi and nourishing blood, which can improve the overall constitution of patients and enhance the immunity of the body, which is helpful for the recovery of the disease, and the clinical effective rate is more than 70%, and the cure rate is more than 40% in three months. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the application will be clearly and completely described below with reference to the embodiments of the application. Obviously, the described embodiments are only a part of the embodiments of the application, rather than all the embodiments of the application. Based on the embodiments in the application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the application.

[0023] Embodiment one:

[0024] The application provides a kind of oral medicine formula for treating psoriasis, which comprises the following raw materials: astragalus, smilax glabra, salvia miltiorrhiza, cassia twig, periostracum cicada, ligusticum wallichii, angelica and licorice.

[0025] The following raw materials are used to make it: 10g of astragalus, 50g of smilax glabra, 10g of salvia miltiorrhiza, 10g of cassia twig, 10g of periostracum cicada, 10g of ligusticum wallichii, 30g of angelica and 10g of licorice.

[0026] An oral medicine formula for treating psoriasis comprises the following steps:

[0027] S1. Drug acceptance and selection, strictly accept the medicinal materials, according to "Chinese Pharmacopoeia" and related medicinal material standards, carefully check the appearance shape, texture and smell of each medicinal material, and remove the medicinal materials that do not meet the quality requirements;

[0028] S2. Cleaning, the selected qualified medicinal materials are respectively put into the cleaning pool, and the flowing clean water is used for cleaning. For the medicinal materials with hard texture, stirring cleaning is adopted to remove the surface mud and dust;

[0029] S3. Drying, the cleaned medicinal materials are treated by manual drying, and a drying machine is used for drying. The temperature is controlled at 50-60°C, and the materials are turned over to ensure uniform drying. The moisture content of the dried medicinal materials should be controlled at 5-10%;

[0030] S4. Extraction, the water decoction extraction method is used for extraction. A corrosion-resistant and evenly heated extraction container is selected. The dried traditional Chinese medicine is placed in the prepared container. 8-10 times the weight of the medicinal material of pure water is added to the container. A large fire is used to heat to boiling, and then a small fire is used to decoct for 60 minutes. Then the medicinal liquid is taken out and cooled for standby. Then 6-8 times the weight of the pure water is added to the container. A large fire is used to heat to boiling, and then a small fire is used to decoct for 40 minutes. The medicinal liquid is taken out and mixed with the medicinal liquid taken out in the first time;

[0031] S5. Filtration, the two medicinal liquids in S4 are mixed and stirred uniformly. The extraction liquid is filtered with multiple layers of gauze to remove the internal dregs and impurities, so as to ensure that there is no suspended matter and precipitate in the medicinal liquid;

[0032] S6. Preparation forming, the filtered extraction liquid can be directly packaged into bags or bottled;

[0033] S7. Quality control, including but not limited to microscopic identification, chemical reaction and thin layer chromatography to identify the effective components in the traditional Chinese medicine preparation, so as to ensure that the preparation contains the specified traditional Chinese medicine components.

[0034] Among them, Huangqi has the effects of tonifying qi, consolidating the exterior, promoting water circulation and reducing swelling. In the treatment of psoriasis, Huangqi can enhance the body's immunity and improve the overall constitution of the patient, thereby helping to relieve the disease;

[0035] Tufuling has the effects of detoxifying, removing dampness and unblocking joints. Tufuling can effectively remove the damp-heat toxins in the body and reduce the inflammatory reaction of the skin. At the same time, Tufuling can also improve the symptoms of joints, and has a certain relieving effect on some psoriasis patients with arthritis;

[0036] Danshen has the effects of promoting blood circulation and removing blood stasis, and cooling blood and resolving abscesses. Danshen can improve blood circulation and reduce local blood stasis in the skin, thereby helping to reduce the color and thickness of the skin lesions. In addition, Danshen also has certain anti-inflammatory effect, which can reduce the inflammatory reaction of the skin;

[0037] Cassia twig has the effect of inducing perspiration and warming meridians, and can promote blood circulation, improve the microcirculation of the skin, and make the medicine better reach the diseased area to play a role;

[0038] Cantala has the effect of dispelling wind-heat and benefiting the throat, and can help relieve the symptoms of skin itching, and has certain anti-allergic effect, which can reduce the inflammatory reaction of the skin caused by allergic factors;

[0039] Chuanxiong has the effect of promoting blood circulation and relieving pain, and can promote blood circulation, improve the blood circulation of the skin, and help reduce the color and thickness of the skin lesions, in addition, Chuanxiong can also relieve pain and discomfort caused by skin lesions;

[0040] Angelica has the effect of tonifying blood and regulating menstruation, and its role in treating psoriasis mainly lies in its function of tonifying blood and regulating menstruation, which can improve the blood supply of the skin, promote the metabolism of the skin, and help repair the skin lesions, in addition, Angelica also has certain moisturizing effect, which can improve the dryness of the skin;

[0041] Gancao has the effect of tonifying the center and benefiting qi, and can adjust the properties of various drugs, making the drug effect more mild and lasting. For patients with psoriasis, Gancao can enhance the body's immunity and improve the function of the spleen and stomach, thereby helping to improve the treatment effect.

[0042] Although the embodiments of the present application have been shown and described, it can be understood by those skilled in the art that various changes, modifications, replacements and variations can be made to the embodiments without departing from the principles and spirits of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. An oral medication formulation for treating psoriasis, characterized in that: It includes the following ingredients: Astragalus membranaceus, Smilax glabra, Salvia miltiorrhiza, Cinnamomum cassia, Cicadae periostracum, Ligusticum chuanxiong, Angelica sinensis, and Glycyrrhiza uralensis (processed).

2. The oral medication formulation for treating psoriasis according to claim 1, characterized in that: It is made from the following ingredients by weight: Astragalus membranaceus 10g, Smilax glabra 50g, Salvia miltiorrhiza 10g, Cinnamomum cassia twig 10g, Cicadae periostracum 10g, Ligusticum chuanxiong 10g, Angelica sinensis 30g, and Glycyrrhiza uralensis (processed) 10g.

3. An oral medication formulation for treating psoriasis, characterized in that: Includes the following steps: S1. Acceptance and selection of medicinal materials: Strict acceptance of medicinal materials, in accordance with the Chinese Pharmacopoeia and relevant medicinal material standards, carefully inspecting the appearance, texture and odor of each medicinal material, and removing those that do not meet the quality requirements; S2. Cleaning: Select qualified medicinal materials and place them into the cleaning pool. Clean them with running water. For medicinal materials with a harder texture, stir and clean them to remove mud and dust from the surface. S3. Drying: The cleaned medicinal materials are dried manually using a dryer at a temperature of 50°C to 60°C. The materials are turned frequently to ensure even drying. The moisture content of the dried medicinal materials should be controlled between 5% and 10%. S4. Extraction: Extraction is carried out by water decoction. Select an extraction container that is corrosion-resistant and heats evenly. Place the dried Chinese medicine in the prepared container and add 8 to 10 times the weight of the medicine in purified water. Heat to a boil over high heat, then reduce to low heat and decoct for 60 minutes. Remove the liquid and let it cool. Then add 6 to 8 times the weight of purified water to the container and heat to a boil over high heat, then reduce to low heat and decoct for 40 minutes. Remove the liquid and mix it with the liquid extracted the first time. S5. Filtration: Mix and stir the two medicinal solutions from step S4 until they are evenly mixed. Filter the extract through multiple layers of gauze to remove the internal residue and impurities, ensuring that there are no suspended matter or sediment in the medicinal solution. S6. Formulation: The filtered extract can be directly packaged into bags or bottles. S7. Quality control, including but not limited to the use of microscopic identification, chemical reaction and thin-layer chromatography to identify the active ingredients in traditional Chinese medicine preparations, to ensure that the preparations contain the prescribed traditional Chinese medicinal ingredients.