A proton Flash therapy device based on a linear induction accelerator

Abstract

The present invention discloses a proton Flash therapy device based on a linear induction accelerator, which includes a proton injector, a linear induction acceleration mechanism, a beam current regulation mechanism, a radiation dose rate measurement system, a pulse power source system, and a pulse transmission system; the linear induction acceleration mechanism is configured to be connected to the proton injector; the beam current regulation mechanism is configured to be connected to the linear induction acceleration mechanism; the radiation dose rate measurement system is used to measure and monitor the dose rate of the proton beam passing through the beam current regulation mechanism in real time; the pulse power source system is used to provide pulse power for the proton injector and the linear induction acceleration mechanism; the pulse transmission system is used to effectively transmit the pulse power generated in the pulse power source system to the proton injector and the linear induction acceleration mechanism; the proton Flash therapy device based on the linear induction accelerator has a simple structure and is suitable for popularization and use in major hospitals.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a proton Flash therapy device based on a linear induction accelerator. Background Art

[0002] Currently, research shows that compared with conventional radiotherapy, the incidence of radioactive dermatitis in proton Flash therapy is reduced by an average of 35%. Moreover, when protons penetrate biological tissues, their depth-dose distribution characteristics are very suitable for tumor treatment. The kinetic energy loss of protons is mainly concentrated at the end of the range, presenting a sharply enhanced Bragg peak. By adjusting the proton energy and beam position, the position of this Bragg peak can be accurately located on tumor cells to obtain the maximum killing effect, while effectively ensuring that healthy tissues are protected from radiation damage. Existing proton Flash therapy research and application devices are generally based on cyclotron main accelerators or radio frequency linear accelerators. Such devices are large and complex in volume, with high construction and operation costs, and the treatment cost is expensive. Therefore, there is a need for improvement. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a proton Flash therapy device based on a linear induction accelerator with a simple structure, which is suitable for popularization and use in major hospitals.

[0004] To solve the above problems, the present invention adopts the following technical solutions:

[0005] A proton Flash therapy device based on a linear induction accelerator includes a proton injector, a linear induction acceleration mechanism, a beam current regulation mechanism, a radiation dose rate measurement system, a pulse power source system, and a pulse transmission system.

[0006] The proton injector is used to generate a proton beam with a high peak current intensity, and pre-accelerate and focus the proton beam.

[0007] The linear induction acceleration mechanism is configured to be connected to the proton injector and is used to accelerate the proton beam so that the proton beam reaches the energy required for treatment.

[0008] The beam current regulation mechanism is configured to be connected to the linear induction acceleration mechanism and is used to perform energy regulation and configuration regulation on the proton beam accelerated by the linear induction acceleration mechanism.

[0009] The radiation dose rate measurement system is used to perform real-time measurement and monitoring on the dose rate of the proton beam passing through the beam current regulation mechanism.

[0010] The pulse power source system is used to provide pulse power for the proton injector and the linear induction acceleration mechanism, and form a pulse electric field required for the accelerated beam current.

[0011] The pulse transmission system is used to effectively transmit the pulse power generated in the pulse power source system to the proton injector and the linear induction acceleration mechanism.

[0012] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the proton injector includes: a hydrogen plasma source and an injector induction cavity assembly.

[0013] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the hydrogen plasma source is a solid electrode vacuum arc discharge proton source or a laser ablation proton source.

[0014] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the linear induction acceleration mechanism includes: at least two modular induction acceleration cavities; wherein, the at least two modular induction acceleration cavities are connected in series.

[0015] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the pulse power source system includes: an injector power source and at least two modular induction acceleration cavity power sources.

[0016] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the modular induction acceleration cavity has a helical coil, and the helical coil is used to generate a focusing magnetic field in the central drift section of the modular induction acceleration cavity to effectively constrain and regulate the proton beam.

[0017] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, it further includes: an external delay controller, which is used to control the pulse power source system to feed pulse power to the at least two modular induction acceleration cavities and gradually accelerate the proton beam entering the linear induction acceleration mechanism.

[0018] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the pulse transmission system includes: an injector transmission line and at least two induction acceleration cavity transmission lines; wherein, one end of the injector transmission line is connected to the injector power source, and the other end of the injector transmission line is connected to the injector induction cavity assembly;

[0019] Among them, the number of induction acceleration cavity transmission lines is the same as that of the modular induction acceleration cavity power sources, and one end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity power source one by one. The number of induction acceleration cavity transmission lines is the same as that of the modular induction acceleration cavities, and the other end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity one by one.

[0020] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the radiation dose rate measurement system includes: a dose rate meter and a dose rate monitor.

[0021] In the proton Flash therapy device based on a linear induction accelerator provided by at least one embodiment of the present disclosure, the beam control mechanism includes: a beam energy controller and a beam configuration controller.

[0022] The beneficial effects of the present invention are as follows: simple structure, high proton energy, high proton beam dose rate, narrow pulse width, meeting the requirements of Flash therapy, being widely applicable to Flash radiotherapy, and being suitable for popularization and use in major hospitals. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for description in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0024] Figure 1 It is a block diagram of component connections of a proton Flash therapy device based on a linear induction accelerator in some embodiments of the present disclosure.

[0025] Figure 2 It is a schematic structural diagram of a proton injector in some embodiments of the present disclosure.

[0026] Figure 3 It is a schematic structural diagram of a proton injector in some embodiments of the present disclosure.

[0027] Figure 4 It is a schematic structural diagram of one of the induction acceleration cavities of a linear induction acceleration mechanism in some embodiments of the present disclosure.

[0028] In the figure:

[0029] 1. Proton injector; 11. Hydrogen plasma source; 110. Hydrogen-containing electrode plate; 111. Stainless steel electrode; 112. Optical platform; 113. Laser; 114. First reflector; 115. Second reflector; 116. Focusing mirror; 12. Injector induction cavity assembly; 120. Injector induction cavity; 121. Injector magnetic core; 122. Injector high-voltage coaxial cable; 123. Inner electrode rod;

[0030] 2. Linear induction acceleration mechanism; 21. Induction acceleration cavity; 210. Induction acceleration cavity body; 211. Linear induction acceleration mechanism magnetic core; 212. Helical coil; 213. Linear induction acceleration mechanism high-voltage coaxial cable;

[0031] 3. Beam control mechanism; 31. Beam energy controller; 32. Beam configuration controller;

[0032] 4. Radiation dose rate measurement system; 41. Dose rate meter; 42. Dose rate monitor;

[0033] 5. Pulse power source system; 51. Injector power source; 52. Induction acceleration cavity power source;

[0034] 6. Pulse transmission system; 61. Injector transmission line; 62. Induction acceleration cavity transmission line;

[0035] 7. Proton beam;

[0036] 8. External flange. Specific implementation manner

[0037] Next, the technical solutions in the embodiments will be clearly and completely described in conjunction with the accompanying drawings in the embodiments. Obviously, the described embodiments are only a part of the embodiments, rather than all the embodiments.

[0038] In the embodiments, it should be understood that the orientation or positional relationships indicated by terms such as "middle", "upper", "lower", "top", "right side", "left end", "above", "back", "middle", etc. are based on the orientation or positional relationships shown in the accompanying drawings, and are only for the convenience of description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention. Unless otherwise defined, the technical terms or scientific terms used in this disclosure should be the ordinary meanings understood by those of ordinary skill in the art to which this disclosure belongs. The "first", "second" and similar terms used in this disclosure do not denote any order, quantity or importance, but are only used to distinguish different components. Words such as "including" or "comprising" mean that the elements or objects appearing before this word cover the elements or objects listed after this word and their equivalents, without excluding other elements or objects.

[0039] In addition, in the description of the present invention, it should be noted that, unless otherwise clearly specified and defined, terms such as "installation", "connection", and "coupling" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0040] At least one embodiment of the present disclosure provides a proton Flash therapy device based on a linear induction accelerator, including a proton injector, a linear induction acceleration mechanism, a beam current regulation mechanism, a radiation dose rate measurement system, a pulse power source system, and a pulse transmission system; the proton injector is used to generate a proton beam with a high peak current intensity and perform pre-acceleration and focusing. The linear induction acceleration mechanism is configured to be connected to the proton injector and is used to accelerate the proton beam so that the proton beam reaches the energy required for treatment. The beam current regulation mechanism is configured to be connected to the linear induction acceleration mechanism and is used to perform energy regulation and configuration regulation on the proton beam accelerated by the linear induction acceleration mechanism. The radiation dose rate measurement system is used to perform real-time measurement and monitoring on the dose rate of the proton beam passing through the beam current regulation mechanism. The pulse power source system is used to provide pulse power for the proton injector and the linear induction acceleration mechanism and form a pulse electric field required for the accelerated beam current. The pulse transmission system is used to effectively transmit the pulse power generated in the pulse power source system to the proton injector and the linear induction acceleration mechanism. The proton injector includes: a hydrogen plasma source and an injector induction cavity assembly. The hydrogen plasma source is a solid electrode vacuum arc discharge proton source or a laser ablation proton source. The linear induction acceleration mechanism includes: at least two modular induction acceleration cavities; wherein, the at least two modular induction acceleration cavities are connected in series. The pulse power source system includes: an injector power source and at least two modular induction acceleration cavity power sources. The modular induction acceleration cavity has a helical tube coil, and the helical tube coil is used to generate a focusing magnetic field in the central drift section of the modular induction acceleration cavity to effectively constrain and regulate the proton beam.

[0041] In at least one embodiment of the present disclosure, a proton Flash therapy device based on a linear induction accelerator further includes: an external delay controller for controlling the pulse power source system to feed pulse power to at least two modular induction acceleration cavities and gradually accelerating the proton beam entering the linear induction acceleration mechanism. The pulse transmission system includes: an injector transmission line and at least two induction acceleration cavity transmission lines; wherein one end of the injector transmission line is connected to the injector power source, and the other end of the injector transmission line is connected to the injector induction cavity assembly; wherein the number of induction acceleration cavity transmission lines is the same as the number of modular induction acceleration cavity power sources, and one end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity power source one by one, the number of induction acceleration cavity transmission lines is the same as the number of modular induction acceleration cavities, and the other end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity one by one. The radiation dose rate measurement system includes: a dose rate meter and a dose rate monitor. The beam control mechanism includes: a beam energy controller and a beam configuration controller.

[0042] The following will provide an overall introduction to the proton Flash therapy device based on a linear induction accelerator according to the embodiments of the present disclosure with reference to the accompanying drawings.

[0043] As Figure 1 shown, the proton Flash therapy device based on a linear induction accelerator according to at least one embodiment of the present disclosure includes a proton injector 1, a linear induction acceleration mechanism 2, a beam control mechanism 3, a radiation dose rate measurement system 4, a pulse power source system 5, a pulse transmission system 6, and an external delay controller (not shown).

[0044] The function of the proton injector 1 is to generate a proton beam with a high peak current intensity and pre-accelerate and focus the proton beam for matching the main accelerator (not shown) at the rear end. The proton injector 1 includes a hydrogen plasma source 11 and an injector induction cavity assembly 12.

[0045] The function of the linear induction acceleration mechanism 2 is to accelerate the proton beam 7 provided by the proton injector 1 and reach the maximum energy required for proton Flash therapy at the outlet. It is connected to the proton injector 1 and includes a plurality of identical modular induction acceleration cavities 21 connected in series.

[0046] The function of the beam control mechanism 3 is to perform energy control and configuration control on the proton beam 7 accelerated by the linear induction acceleration mechanism 2 to obtain an energy range and beam configuration that meet the requirements of proton Flash therapy. It is connected to the linear induction acceleration mechanism 2 and includes a beam energy controller 31 and a beam configuration controller 32.

[0047] The function of the radiation dose rate measurement system 4 is to measure and monitor the dose rate of the proton beam 7 after beam current regulation in real time to meet the requirements for the dose rate during actual proton Flash therapy. The radiation dose rate measurement system 4 includes a dose rate meter 41 and a dose rate monitor 42.

[0048] The function of the pulsed power source system 5 is to provide pulsed power for the proton injector 1 and the linear induction accelerator mechanism 2. The pulsed power source system 5 includes an injector power source 51 and multiple identical modular induction accelerator cavity power sources 52, so that the injector induction cavity assembly 12 and multiple modular induction accelerator cavities 21 form the pulsed electric field required to accelerate the beam current.

[0049] The function of the pulsed transmission system 6 is to effectively transmit the pulsed power generated in the pulsed power source system 5 to the injector induction cavity assembly 12 and multiple modular induction accelerator cavities 21; the pulsed transmission system 6 includes an injector transmission line 61 and an induction accelerator cavity transmission line 62;

[0050] Among them, one end of the injector transmission line 61 is connected to the injector power source, and the other end of the injector transmission line 61 is connected to the injector induction cavity assembly 12;

[0051] The number of induction accelerator cavity transmission lines 62 is the same as that of the modular induction accelerator cavity power sources 52, and one end of the induction accelerator cavity transmission line 62 is connected to the modular induction accelerator cavity power source 52 one by one. The number of induction accelerator cavity transmission lines 62 is the same as that of the modular induction accelerator cavities 21, and the other end of the induction accelerator cavity transmission line 62 is connected to the modular induction accelerator cavity 21 one by one.

[0052] As Figure 4 shown, the induction accelerator cavity 21 includes: an induction accelerator cavity body 210, a linear induction accelerator mechanism magnetic core 211, a linear induction accelerator mechanism high-voltage coaxial cable 213, and an induction accelerator cavity power source 52, where: the linear induction accelerator mechanism magnetic core 211 is used to generate a high voltage for accelerating protons in the gap of the induction accelerator cavity 21 through the principle of electromagnetic induction.

[0053] As Figure 1 and 2 shown, in some embodiments, the proton injector 1 includes: a hydrogen plasma source 11 and an injector induction cavity assembly 12, where:

[0054] The hydrogen plasma source 11 generates hydrogen plasma by means of vacuum arc discharge with a solid-state electrode for subsequent extraction of protons. It includes two parts: a hydrogen-containing electrode sheet 110 and a stainless steel electrode 111;

[0055] The function of the injector induction cavity assembly 12 is to extract protons from the plasma generated by the hydrogen plasma source 11 and perform pre-acceleration. It includes an injector induction cavity 120, an injector magnetic core 121, an injector high-voltage coaxial cable 122, and an inner electrode rod 123;

[0056] The hydrogen-containing electrode plate 110 is installed at the head of the inner electrode rod 123. The center of the hydrogen-containing electrode plate 110 and the center of the stainless-steel electrode 111 are on the same central axis, and there is a certain gap between the hydrogen-containing electrode plate 110 and the stainless-steel electrode 111. The stainless-steel electrode 111 is a stainless-steel disc with a hole in the middle and is connected to the housing of the proton injector 1. The pre-accelerated proton beam 7 exits from the middle hole of the stainless-steel electrode 111 and enters the subsequent linear induction acceleration mechanism 2.

[0057] As Figure 1 and 3 shown, in some embodiments, the proton injector 1 includes: a hydrogen plasma source 11 and an injector induction cavity assembly 12, where:

[0058] The hydrogen plasma source 11 uses a laser ablation plasma source as the component for generating hydrogen plasma, which is used for subsequent extraction of protons. It includes a hydrogen-containing electrode plate 110, a stainless-steel electrode 111, an optical platform 112, a laser 113, a first mirror 114, a second mirror 115, and a focusing mirror 116;

[0059] The optical platform 112 is used to place the laser 113, the first mirror 114, and the second mirror 115; the laser 113 is used to provide a laser beam for this laser ablation plasma source; the first mirror 114, the second mirror 115, and the focusing mirror 116 form an optical path system for propagating the laser beam generated by the laser 113 to the hydrogen-containing electrode plate 110 and bombarding to generate hydrogen plasma;

[0060] The function of the injector induction cavity assembly 12 is to extract protons from the plasma generated by the hydrogen plasma source 11 and perform pre-acceleration. It includes an injector induction cavity 120, an injector magnetic core 121, an injector high-voltage coaxial cable 122, and an inner electrode rod 123; where the hydrogen-containing electrode plate 110 is installed at the head of the inner electrode rod 123. The center of the hydrogen-containing electrode plate 110 and the center of the stainless-steel electrode 111 are on the same central axis, and there is a certain gap between the hydrogen-containing electrode plate 110 and the stainless-steel electrode 111; the stainless-steel electrode 111 is a cylinder and is connected to the external flange 8. The proton beam 7 passes through the stainless-steel electrode 111 and exits from the external flange 8 and enters the subsequent linear induction acceleration mechanism 2.

[0061] In some embodiments, the hydrogen plasma source 11 of the proton injector 1 uses a solid - state electrode vacuum arc discharge proton source or a laser ablation plasma proton source. The solid - state electrode vacuum arc discharge proton source uses a titanium hydride electrode, and the ratio of hydrogen atoms to titanium atoms in the titanium hydride electrode is 0.5 - 1.6. The arc current of the solid - state electrode vacuum arc discharge proton source is 0.1 - 1 kA, and the pulse width is 0.1 - 0.5 μs. The laser ablation plasma proton source uses polyethylene as the laser - bombarded target, the laser power is 1.5 J, the wavelength is 1064 nm, and the pulse width is 9 ns. The injector induction cavity assembly 12 of the proton injector 1 uses the induction superposition technology, and a proton beam with a proton energy range of 3 - 5 MeV, a peak current intensity of 0.2 - 1 A, a repetition frequency of 1 - 10 Hz, and a pulse width of 50 - 100 ns can be obtained at the outlet of the proton injector 1.

[0062] In some embodiments, the linear induction acceleration mechanism 2 includes a number of modular induction acceleration cavities 21, and the induction acceleration cavities 21 are connected in series in turn. The acceleration gradient of a single induction acceleration cavity is 0.5 - 1 MV. Each induction acceleration cavity 21 includes an induction cavity and a magnetic core. The induction cavity is made of non - magnetic stainless steel 306L, with an outer diameter of 200 - 350 mm, an inner diameter of 40 - 180 mm, and a thickness of 30 - 100 mm. The magnetic core has an inner diameter of 50 - 200 mm, an outer diameter of 100 - 250 mm, a thickness of 25 - 50 mm, and is made of an iron - based amorphous magnetic material.

[0063] In some embodiments, the acceleration gradient of a single induction acceleration cavity 21 is 1 MV, the proton energy output by the proton injector 1 is 5 MeV, and 15 induction acceleration cavities 21 are connected in series. A proton energy of 20 MeV can be obtained at the outlet of the linear induction acceleration mechanism 2.

[0064] As Figure 4 shown, in some embodiments, a helical coil 212 is added to the induction acceleration cavity 21, and a focusing magnetic field can be generated in the central drift section of each induction acceleration cavity 21. The axial magnetic induction intensity is 0.1 T, which can effectively constrain and regulate the proton beam 7 and avoid the loss of beam divergence and wall - hitting.

[0065] In some embodiments, the beam control mechanism 3 includes a beam energy regulator 31 and a beam configuration regulator 32. The beam energy regulator 31 uses an energy - reducing sheet, and the energy - reducing sheet has a mass thickness of 0.5 - 4.0 g / cm 2Graphite, according to the requirements of tumor size of 10mm and depth from the body surface of 50mm, by adjusting the initial proton energy of 200MeV, the peak position and peak width of the proton range Bragg peak are changed to meet the requirements of tumor size and depth; illustratively, the beam shape controller 32 uses a mechanical slit or collimator or scatterer or electromagnetic scanning system to regulate the uniformity and shape of the beam radiation field so that it meets the requirements of the tumor appearance shape for the proton beam 7.

[0066] In some embodiments, the radiation dose rate measurement system 4 includes a dose rate meter 41 and a dose rate monitor 42; illustratively, the dose rate meter 41 uses radioactive film or a scintillator detector or an ultrasonic transducer to measure the proton radiation dose rate in real time after bombardment by the proton beam 7; the dose rate monitor 42 uses an instantaneous gamma ray meter based on inorganic scintillator detectors such as YAP:Ce, PbWO4, LaCl3:Ce, etc., to monitor the dose rate level during proton Flash therapy in real time.

[0067] In some embodiments, the pulse power source system 5 includes an injector power source 51 and multiple identical induction acceleration cavity power sources 52, wherein the injector power source 51 has an output voltage of 3-5MV and an output peak power of 0.6-5MW, which is used to provide pulse power to the proton injector 1; the induction acceleration cavity power source 52 has a single output voltage of 0.5-1MV and an output peak power of 0.1-1MW, which is used to provide pulse power to a single induction acceleration cavity 21; multiple induction acceleration cavities 21 need to be equipped with multiple identical induction acceleration cavity power sources 52 at the same time to achieve power output for the entire linear induction acceleration mechanism 2.

[0068] In some embodiments, the pulse transmission system 6 uses a water medium Blumlein pulse forming line, and the pulse transmission system 6 includes an injector transmission line 61 and multiple induction acceleration cavity transmission lines 62. One end of the injector transmission line 61 is connected to the injector power source 51, and the other end is connected to the injector induction cavity assembly 12 to feed pulse power thereto; one end of the single induction acceleration cavity transmission line 62 is connected to the induction acceleration cavity power source 52, and the other end is connected to the single induction acceleration cavity 21 to feed power thereto.

[0069] The working principle of the present disclosure is further described below according to the working mode of the proton flash therapy device based on the linear induction accelerator provided by at least one embodiment of the present disclosure;

[0070] The working method of the proton flash therapy device based on the linear induction accelerator includes the following steps:

[0071] 1) The external delay controller controls the injector power source, and through the injector transmission line, feeds pulsed power to the hydrogen plasma source and the injector induction cavity assembly, enabling the hydrogen plasma source to generate a dense hydrogen-containing plasma. Among them, protons are pre-accelerated by the injector induction cavity assembly to obtain a primary acceleration energy of 3 - 5 MeV, and the pulse duration is 50 - 100 ns;

[0072] 2) The external delay controller controls the power sources of each induction acceleration cavity in the pulsed power source system, and through the induction acceleration cavity transmission line, feeds pulsed power to each group of induction acceleration cavities respectively, enabling the proton beam entering the linear induction acceleration mechanism to be accelerated step by step and obtaining an acceleration energy of 20 - 300 MeV at the exit;

[0073] 3) The proton beam emitted from the linear induction acceleration mechanism enters the beam control mechanism, and the energy and configuration of the proton beam are controlled according to the actual needs of subsequent Flash therapy;

[0074] 4) The proton beam emitted from the beam control mechanism passes through the radiation dose rate measurement system to measure and monitor the Flash therapy dose rate in real time to ensure that the treatment requirements are met.

[0075] In some embodiments, the working method of the proton injector includes the following steps:

[0076] STEP1. The external delay controller controls the injector power source, and through the injector transmission line, feeds pulsed power to the corresponding injector induction cavity via a multi-channel injector high-voltage coaxial cable;

[0077] STEP2. Multiple injector induction cavities adopt an induction stacker design, and through the central inner electrode rod, the pulsed high voltage is stacked on the hydrogen-containing electrode plate at the end of the inner electrode rod;

[0078] STEP3. The pulsed high voltage causes arc discharge breakdown between the hydrogen-containing electrode plate and the stainless steel electrode, generating a dense hydrogen-containing plasma;

[0079] STEP4. Protons in the plasma are accelerated by the pulsed high voltage of the inner electrode rod, and a proton beam exits at the proton injector outlet and enters the subsequent linear induction acceleration mechanism.

[0080] In still other embodiments, the working method of the proton injector includes the following steps:

[0081] STEP1. The external delay controller controls the injector power source to provide pulsed power and the laser to generate a laser beam by setting the delay;

[0082] STEP2. The injector power source passes through the injector transmission line and feeds pulsed power to the corresponding injector induction cavity via a multi-channel injector high-voltage coaxial cable;

[0083] STEP 3. The induction cavities of multiple injectors adopt an induction superposer design. Through the central inner electrode rod, the pulsed high voltage is superposed on the hydrogen-containing electrode piece at the end of the inner electrode rod.

[0084] STEP 4. The laser beam generated by the laser passes through the first mirror, the second mirror and the focusing mirror, and then bombards the hydrogen-containing electrode piece to generate laser ablation plasma.

[0085] STEP 5. The protons in the plasma obtain velocity under the action of the pulsed high voltage formed at the end of the inner electrode rod. After passing through the stainless steel electrode, they exit from the outer flange of the proton injector and enter the subsequent linear induction acceleration mechanism.

[0086] In the description of this specification, the description with reference to terms such as "this embodiment", "some embodiments", "other embodiments" or "specific examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0087] Although the embodiments of the present application have been shown and described above, the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be thought of without creative work should be covered within the protection scope of the present invention; unless expressly stated, any element, action or instruction used herein should not be construed as critical or essential.

Claims

1. A proton Flash therapy device based on a linear induction accelerator, characterized in that, Comprising: A proton injector for generating a proton beam with a high peak current intensity, and pre-accelerating and focusing the proton beam; A linear induction acceleration mechanism configured to be connected to the proton injector for accelerating the proton beam; A beam current regulation mechanism configured to be connected to the linear induction acceleration mechanism for regulating the energy and configuration of the proton beam accelerated by the linear induction acceleration mechanism; A radiation dose rate measurement system for measuring and monitoring in real time the dose rate of the proton beam passing through the beam current regulation mechanism; A pulse power source system for providing pulse power to the proton injector and the linear induction acceleration mechanism, and for forming a pulse electric field required for accelerating the proton beam current; And A pulse transmission system for effectively transmitting the pulse power generated in the pulse power source system to the proton injector and the linear induction acceleration mechanism; The proton injector includes: A hydrogen plasma source; And An injector induction cavity assembly; The hydrogen plasma source uses a laser ablation plasma source as a component for generating hydrogen plasma for subsequent extraction of protons. The hydrogen plasma source includes a hydrogen-containing electrode plate, a stainless steel electrode, an optical platform, a laser, a first reflector, a second reflector, and a focusing mirror; The function of the injector induction cavity assembly is to extract protons from the plasma generated by the hydrogen plasma source and perform pre-acceleration. The injector induction cavity assembly includes an injector induction cavity, an injector magnetic core, an injector high-voltage coaxial cable, and an inner electrode rod.

2. The proton Flash therapy device based on a linear induction accelerator according to claim 1, wherein The hydrogen plasma source is a solid electrode vacuum arc discharge proton source or a laser ablation proton source.

3. The proton Flash therapy device based on a linear induction accelerator according to claim 1, characterized in that, The linear induction acceleration mechanism includes: At least two modular induction acceleration cavities; Wherein, the at least two modular induction acceleration cavities are connected in series.

4. A proton Flash therapy device based on a linear induction accelerator according to claim 3, characterized in that, The pulse power source system includes: An injector power source; And At least two modular induction acceleration cavity power sources.

5. A proton Flash therapy device based on a linear induction accelerator according to claim 3, characterized in that, The modular induction acceleration cavity has a helical coil for generating a focusing magnetic field in the central drift section of the modular induction acceleration cavity to effectively constrain and regulate the proton beam current.

6. The proton Flash therapy device based on a linear induction accelerator according to claim 3, wherein It further includes: An external delay controller for controlling the pulse power source system to feed pulse power to the at least two modular induction acceleration cavities and enabling the proton beam entering the linear induction acceleration mechanism to be accelerated step by step.

7. A proton Flash therapy device based on a linear induction accelerator according to claim 4, characterized in that, The pulse transmission system includes: An injector transmission line; And At least two induction acceleration cavity transmission lines; Wherein, one end of the injector transmission line is connected to the injector power source, and the other end of the injector transmission line is connected to the injector induction cavity assembly; Wherein, the number of induction acceleration cavity transmission lines is the same as the number of modular induction acceleration cavity power sources, and one end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity power source one by one. The number of induction acceleration cavity transmission lines is the same as the number of modular induction acceleration cavities, and the other end of each induction acceleration cavity transmission line is connected to a modular induction acceleration cavity one by one.

8. A proton Flash therapy device based on a linear induction accelerator according to claim 1, characterized in that, The radiation dose rate measurement system includes: A dose rate meter; and A dose rate monitor.

9. A proton Flash therapy device based on a linear induction accelerator according to claim 1, characterized in that, The beam current regulation mechanism includes: A beam energy regulator; and A beam configuration regulator.

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