Sevelamer Carbonate for Oral Suspension and Its Preparation Method

Through the specific ratio and preparation process of severam carbonate dry suspension, the problem of inability to improve gastrointestinal side effects in the prior art is solved, and good dispersion and taste are achieved, while reducing the occurrence of side effects.

CN116270722BActive Publication Date: 2025-07-25HUBEI HUASHITONG BIOMEDICAL TECH CO LTD
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Patent Information

Application Number
CN202310205829.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-03-06
Publication Date
2025-07-25
Estimated Expiration
2043-03-06

AI Technical Summary

Technical Problem

Although the existing severam carbonate dry suspension improves dispersion, it cannot improve its common gastrointestinal side effects such as constipation, indigestion, inadequate intestinal motility and intestinal obstruction.

Method used

The content of severam carbonate is prepared by selecting specific proportions of suspending agents, flocculants, lactulose and flavoring agents, especially using propylene alginate, sodium chloride and water-soluble flavors, and by preparing preparation processes such as mixing, sieving, wet granulation and drying to form dry granules.

Benefits of technology

It improves the gastrointestinal side effects of severam carbonate dry suspension, while maintaining good redispersity and taste, reducing the occurrence of side effects such as constipation, indigestion, inadequate intestinal motility and intestinal obstruction.

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Abstract

The present invention relates to the field of pharmaceutical preparations, and in particular, to a sevelamer carbonate dry suspension and a preparation method thereof. In the sevelamer carbonate dry suspension, the dosage of the suspending agent is 0.13 - 0.33% of the total mass, the dosage of the flocculant is 0.05 - 0.39% of the total mass, the dosage of lactulose is 72.53 - 86.90% of the total mass, the dosage of the flavoring agent is 0.34 - 0.72% of the total mass, and the dosage of the sevelamer carbonate crude drug is 12.51 - 26.20% of the total mass. This sevelamer carbonate dry suspension not only has excellent dispersibility, but also can improve its gastrointestinal side effects.
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