Antitumor traditional chinese medicine composition and its preparation and application for preparing pd-1 inhibitor synergist

Abstract

The application discloses an anti-tumor traditional Chinese medicine composition, a preparation method thereof and application of the anti-tumor traditional Chinese medicine composition in preparation of a synergist of a PD-1 inhibitor. The anti-tumor traditional Chinese medicine composition comprises ginsenoside Rg1 and atractylenolide-I, and the mass ratio of the ginsenoside Rg1 to the atractylenolide-I is 4:1-1:4. The composition can further comprise a drug carrier and a surface modification material. In the composition, the ginsenoside Rg1 can regulate the MVA pathway of the normal metabolism of dendritic cell cholesterol, and enhance the antigen presentation capacity of the dendritic cells; the atractylenolide-I can enhance the activity of the immunoproteasome of tumor cells, and then up-regulate the MHC-I expression of the tumor cells. The drug carrier can efficiently co-load the anti-tumor traditional Chinese medicine composition, and the surface modification material can realize the in-vivo Ly6C + macrophage transport of the preparation to the central region of tumor tissues. The anti-tumor traditional Chinese medicine composition of the application can significantly promote the infiltration of T lymphocytes to tumor tissues and recognize and kill tumors, and the combination with the PD-1 inhibitor can significantly improve the anti-MSS type colorectal cancer effect of the PD-1 inhibitor.

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