Antibacterial medical packaging film and preparation method thereof

Abstract

The invention relates to the technical field of packaging film materials, in particular to an antibacterial medical packaging film and a preparation method thereof. The antibacterial medical packaging film is prepared from the following raw materials in parts by weight: 40 to 50 parts of HDPE (High Density Polyethylene), 20 to 35 parts of LLDPE (Linear Low Density Polyethylene), 3 to 5 parts of maleic anhydride grafted polyethylene, 5 to 7 parts of antibacterial agent, 8 to 10 parts of POE (Polyolefin Elastomer), 1 to 3 parts of zinc stearate and 2 to 5 parts of antioxidant, the antibacterial medical packaging film prepared by the invention not only has better antibacterial property, but also has excellent low temperature resistance and mechanical property.

Description

Technical Field

[0001] The present invention relates to the technical field of packaging film materials, and particularly to an antibacterial medical packaging film and a preparation method thereof. Background Technique

[0002] Medical packaging film is a key material for the sterile preservation of medical devices, drugs and biological products. At present, polyethylene (PE) has become the mainstream substrate for medical packaging due to its excellent processing performance and cost advantages.

[0003] However, the traditional polyethylene (PE) medical packaging film has the following problems: (1) The traditional polyethylene (PE) medical packaging film lacks antibacterial function, is easy to become a carrier for microbial growth, and is prone to cause infection risks; (2) The traditional polyethylene (PE) medical packaging film still has a sharp drop in flexibility due to the increase in crystallinity at low temperatures, and cannot meet the requirements of ultra-low temperature cold chain transportation and storage; (3) The reinforcing fillers (such as glass fiber, calcium carbonate) of the traditional polyethylene (PE) medical packaging film can improve the strength, but cause the material to become brittle, and have poor compatibility with the polyethylene (PE) matrix, and are prone to interface peeling.

[0004] Based on this, the present invention provides an antibacterial medical packaging film and a preparation method thereof to solve the above-mentioned technical problems. Summary of the Invention

[0005] The purpose of the present invention is to provide an antibacterial medical packaging film and a preparation method thereof. The prepared antibacterial medical packaging film not only has good antibacterial performance, but also has excellent low-temperature resistance and mechanical properties, effectively ensuring its quality and quality.

[0006] To achieve the above purpose, the present invention provides the following technical solutions: The first aspect of the present invention: provides an antibacterial medical packaging film, which is composed of the following raw materials in parts by weight: 40-50 parts of high-density polyethylene (HDPE), 20-35 parts of linear low-density polyethylene (LLDPE), 3-5 parts of maleic anhydride grafted polyethylene, 5-7 parts of antibacterial agent, 8-10 parts of polyolefin elastomer (POE), 1-3 parts of zinc stearate and 2-5 parts of antioxidant.

[0007] The present invention is further provided as follows: The preparation method of the antibacterial agent is: Lay the carrier substrate flat with a thickness of 3-5 mm, spray the KH550 solution onto the carrier substrate according to a mass ratio of 0.1-0.2:1, and stand for 10-15 min. After drying, obtain the pretreated carrier substrate; Mix nanocrystalline cellulose whiskers and pretreated carrier substrates in a mass ratio of 1:4 to 5 by ball milling under a nitrogen atmosphere, collect the composite powder, and mix the composite powder and pretreated silicon carbide nanowires in a mass ratio of 5:1 to obtain an antibacterial agent.

[0008] The present invention is further configured such that: the rotation speed of the ball milling is 300 - 320 r / min, the ball-to-material ratio is 10:1, and the diameter of the grinding balls is 5 mm.

[0009] The present invention is further configured such that: the KH550 solution is prepared by compounding KH550 and ethanol in a mass ratio of 1:96 to 99.

[0010] The present invention is further configured such that: the preparation method of the pretreated silicon carbide nanowires is as follows: Put silicon carbide nanowires into concentrated nitric acid with a volume concentration of 65% at a solid-liquid ratio of 0.02 - 0.04 g / mL, and perform ultrasonic treatment for 120 - 140 min under the condition of 55 - 60 °C; Then centrifuge at 8000 - 10000 r / min for 10 - 12 min, discard the supernatant, wash with deionized water until neutral, and then dry at 110 - 120 °C for 12 - 14 h to obtain pretreated silicon carbide nanowires.

[0011] The present invention is further configured such that: the preparation method of the carrier substrate is as follows: Put zeolite into ethanol at a solid-liquid ratio of 0.1 - 0.2 g / mL, and then add 6 - 10% of methacryloyloxyethyl dimethyl benzyl ammonium chloride based on the mass of zeolite and mix well; then add 0.5 - 0.6% of ammonium persulfate based on the mass of zeolite, and treat under a nitrogen atmosphere at 70 - 72 °C for 6 - 7 h; centrifuge at 8000 - 10000 r / min for 10 - 12 min, collect the solid, wash with ethanol 2 - 3 times, and then dry at 60 - 70 °C under vacuum for 12 - 14 h to obtain the first base material; Add 120 - 150% of cinnamaldehyde based on the mass of gelatin to the first glue solution and perform ultrasonic treatment for 5 - 10 min, then add 100% of the second glue solution based on the volume of the first glue solution, continue ultrasonic treatment for 2 - 3 min, adjust the pH to 4.0 with glacial acetic acid, then treat at 80 - 100 r / min for 60 - 70 min, cool down to 10 °C, add 0.4 - 0.5% of glutaraldehyde based on the volume of the first glue solution and cure for 100 - 120 min, centrifuge at 8000 - 10000 r / min for 10 - 12 min, collect the solid, wash with deionized water 2 - 3 times, and after spray drying, obtain the second base material; Mix the first base material and the second base material according to a mass ratio of 1:3.2 to 3.5 to obtain a third base material. Then, put the third base material into ethanol according to a solid-liquid ratio of 0.15 to 0.2 g / mL and perform ultrasonic treatment for 20 to 30 minutes, and then dry it at 60 to 70 °C for 8 to 10 hours to obtain a carrier substrate.

[0012] A further setting of the present invention is that the first glue solution is prepared by putting gelatin into deionized water at 50 °C according to a solid-liquid ratio of 0.01 to 0.02 g / mL and stirring for 10 to 12 minutes.

[0013] A further setting of the present invention is that the second glue solution is prepared by putting gum arabic into deionized water according to a solid-liquid ratio of 0.01 to 0.02 g / mL and stirring for 10 to 12 minutes.

[0014] A further setting of the present invention is that the antioxidant is selected from any one of antioxidant 1010, antioxidant 1076, and antioxidant CA.

[0015] The second aspect of the present invention: It also provides a preparation method of the above antibacterial medical packaging film, including the following steps: Step 1: Accurately weigh high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer POE, zinc stearate, and antioxidant, and put high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, polyolefin elastomer POE, zinc stearate, and antioxidant into a mixing device, mix at 1500 to 2000 r / min for 10 to 20 minutes, and then add antioxidant to it and continue to mix for 5 to 10 minutes; Step 2: After mixing evenly, transfer the obtained mixed material into a twin-screw extruder for extrusion granulation to obtain masterbatch; Step 3: Blow the obtained masterbatch through a blown film machine to obtain a finished antibacterial medical packaging film.

[0016] A further setting of the present invention is that in the second step, the extrusion temperature of the twin-screw extruder is divided into 4 zones, the temperature of the first zone is 160 to 165 °C, the temperature of the second zone is 170 to 175 °C, the temperature of the third zone is 180 to 185 °C, and the temperature of the fourth zone is 175 to 180 °C.

[0017] A further setting of the present invention is that in the third step, the die head temperature of the blown film machine is 175 °C, the air ring cooling temperature is 10 to 15 °C, the blow-up ratio is 2.5 to 3:1, and the traction speed is 15 to 20 m / min.

[0018] Compared with the prior art, the beneficial effects of the present invention are: In the present invention, high-density polyethylene (HDPE), linear low-density polyethylene (LLDPE), maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer (POE), zinc stearate, antioxidant, etc. are used as raw materials. By putting HDPE, LLDPE, maleic anhydride grafted polyethylene, POE, zinc stearate and antioxidant into a mixing device for mixing, and then adding antioxidant thereto and continuing to mix, after mixing evenly, the obtained mixed material is transferred into a twin-screw extruder for extrusion granulation to obtain masterbatch. The obtained masterbatch is blown into film by a blown film machine to obtain the finished antibacterial medical packaging film. The prepared antibacterial medical packaging film not only has good antibacterial performance, but also has excellent low-temperature resistance and mechanical properties, effectively ensuring its quality and quality. The antibacterial medical packaging film and its preparation method provided by the present invention have a broader market prospect and are more suitable for popularization. Detailed Embodiments

[0019] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0020] Example 1. This example provides an antibacterial medical packaging film, which is composed of the following raw materials in parts by weight: 40 parts of HDPE, 20 parts of LLDPE, 3 parts of maleic anhydride grafted polyethylene, 5 parts of antibacterial agent, 8 parts of POE, 1 part of zinc stearate and 2 parts of antioxidant.

[0021] In this example, it should be noted that HDPE is purchased from Ningbo Yongyang Plastic Technology Co., Ltd., LLDPE is purchased from Guangdong Yuming New Material Technology Co., Ltd., maleic anhydride grafted polyethylene is purchased from Dongguan Taotao Plastic Raw Material Co., Ltd., and POE is purchased from Suzhou Suzheng Plastic Co., Ltd.

[0022] Among them, the preparation method of the antibacterial agent is as follows: Lay the carrier substrate flat with a thickness of 3 mm, spray the KH550 solution onto the carrier substrate according to a mass ratio of 0.1:1, and stand for 10 min. After drying, the pretreated carrier substrate is obtained; Mix nanocrystalline cellulose whiskers (CNW) and the pretreated carrier substrate in a ball mill under a nitrogen atmosphere according to a mass ratio of 1:4, collect the composite powder, and mix the composite powder and the pretreated silicon carbide nanowires (SiC NWs) according to a mass ratio of 5:1 to obtain the antibacterial agent.

[0023] Further, the rotation speed of the ball milling is 300 - 320 r / min, the ball-to-material ratio is 10:1, and the diameter of the grinding balls is 5 mm.

[0024] Further, the KH550 solution is prepared by compounding KH550 and ethanol according to a mass ratio of 1:96.

[0025] Among them, the preparation method of the pretreated silicon carbide nanowires is as follows: Put the silicon carbide nanowires into concentrated nitric acid with a volume concentration of 65% according to a solid-liquid ratio of 0.02 g / mL, and perform ultrasonic treatment for 120 min at 55 °C; Then centrifuge at 8000 r / min for 10 min, discard the supernatant, wash with deionized water until neutral, and then dry at 110 °C for 12 h to obtain the pretreated silicon carbide nanowires.

[0026] Among them, the preparation method of the carrier substrate is as follows: Put zeolite into ethanol according to a solid-liquid ratio of 0.1 - 0.2 g / mL, and then add 6% of methacryloyloxyethyl dimethyl benzyl ammonium chloride based on the mass of zeolite and mix well; then add 0.5% of ammonium persulfate based on the mass of zeolite, and treat under a nitrogen atmosphere at 70 °C for 6 h; centrifuge at 8000 r / min for 10 min, collect the solid, wash with ethanol twice, and then dry under a vacuum condition at 60 °C for 12 h to obtain the first base material; Add cinnamaldehyde which is 120% of the mass of gelatin to the first glue solution and perform ultrasonic treatment for 5 min, then add the second glue solution which is 100% of the volume of the first glue solution, continue ultrasonic treatment for 2 min, adjust the pH to 4.0 with glacial acetic acid, then treat at 80 r / min for 60 min, cool down to 10 °C, add 0.4% of glutaraldehyde based on the volume of the first glue solution and cure for 100 min, centrifuge at 8000 r / min for 10 min, collect the solid, wash with deionized water twice, and after spray drying, obtain the second base material; Mix the first base material and the second base material according to a mass ratio of 1:3.2 to obtain the third base material, then put the third base material into ethanol according to a solid-liquid ratio of 0.15 g / mL and perform ultrasonic treatment for 20 min, and then dry at 60 °C for 8 h to obtain the carrier substrate.

[0027] In this embodiment, it should be noted that the zeolite is purchased from Jiangsu Deyi Environmental Protection Technology Co., Ltd. and ground to a particle size of 10 μm.

[0028] Further, the first glue solution is prepared by putting gelatin into deionized water at 50 °C according to a solid-liquid ratio of 0.01 - 0.02 g / mL and stirring for 10 min.

[0029] The second adhesive solution was prepared by adding gum arabic to deionized water at a solid-liquid ratio of 0.01 g / mL and stirring for 10 min.

[0030] Among them, antioxidant 1010 was selected as the antioxidant.

[0031] In addition, this embodiment also provides a preparation method of the above antibacterial medical packaging film, including the following steps: Step 1: Accurately weigh high-density polyethylene (HDPE), linear low-density polyethylene (LLDPE), maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer (POE), zinc stearate and antioxidant, and put HDPE, LLDPE, maleic anhydride grafted polyethylene, POE, zinc stearate and antioxidant into a mixing device, mix at 1500 r / min for 10 min, then add antioxidant to it and continue to mix for 5 min; Step 2: After mixing evenly, transfer the obtained mixed material into a twin-screw extruder for extrusion granulation to obtain masterbatch; Among them, the extrusion temperature of the twin-screw extruder is divided into 4 zones. The temperature of the first zone is 160 °C, the temperature of the second zone is 170 °C, the temperature of the third zone is 180 °C, and the temperature of the fourth zone is 175 °C.

[0032] Step 3: Blow the obtained masterbatch through a blown film machine to obtain the finished product of the antibacterial medical packaging film.

[0033] Among them, the die head temperature of the blown film machine is 175 °C, the air ring cooling temperature is 10 °C, the blow-up ratio is 2.5:1, and the traction speed is 15 m / min.

[0034] Example 2, the preparation method of the antibacterial medical packaging film provided in this example is basically the same as that in Example 1, the differences are: the specific raw material composition and the specific preparation method of the antibacterial medical packaging film in this example are different; the specific raw material composition and the specific preparation method of the antibacterial medical packaging film in this example are as follows: An antibacterial medical packaging film is composed of the following raw materials in parts by weight: 45 parts of high-density polyethylene (HDPE), 27 parts of linear low-density polyethylene (LLDPE), 4 parts of maleic anhydride grafted polyethylene, 6 parts of antibacterial agent, 9 parts of polyolefin elastomer (POE), 2 parts of zinc stearate and 3 parts of antioxidant.

[0035] In this example, it should be noted that HDPE was purchased from Ningbo Yongyang Plastic Technology Co., Ltd., LLDPE was purchased from Guangdong Yuming New Material Technology Co., Ltd., maleic anhydride grafted polyethylene was purchased from Dongguan Taotao Plastic Raw Materials Co., Ltd., and POE was purchased from Suzhou Suzheng Plastic Co., Ltd.

[0036] Among them, the preparation method of the antibacterial agent is as follows: Lay the carrier substrate flat with a thickness of 4 mm. Spray the KH550 solution onto the carrier substrate according to a mass ratio of 0.1:1, and let it stand for 12 min. After drying, obtain the pretreated carrier substrate. Mix nanocellulose whiskers (CNW) and the pretreated carrier substrate according to a mass ratio of 1:4 by ball milling under a nitrogen atmosphere, collect the composite powder, and mix the composite powder and the pretreated silicon carbide nanowires (SiC NWs) according to a mass ratio of 5:1 to obtain the antibacterial agent.

[0037] Furthermore, the rotation speed of the ball milling is 300 - 320 r / min, the ball-to-material ratio is 10:1, and the diameter of the grinding balls is 5 mm.

[0038] Furthermore, the KH550 solution is prepared by compounding KH550 and ethanol according to a mass ratio of 1:98.

[0039] Among them, the preparation method of the pretreated silicon carbide nanowires is as follows: Put the silicon carbide nanowires into concentrated nitric acid with a volume concentration of 65% according to a solid-liquid ratio of 0.03 g / mL, and perform ultrasonic treatment for 130 min at 57 °C. Then centrifuge at 9000 r / min for 11 min, discard the supernatant, wash with deionized water until neutral, and then dry at 1105 °C for 13 h to obtain the pretreated silicon carbide nanowires.

[0040] Among them, the preparation method of the carrier substrate is as follows: Put zeolite into ethanol according to a solid-liquid ratio of 0.1 g / mL, and then add 8% of methacryloyloxyethyl dimethyl benzyl ammonium chloride based on the mass of zeolite and mix well; then add 0.5% of ammonium persulfate based on the mass of zeolite, and treat under a nitrogen atmosphere at 71 °C for 7 h; centrifuge at 9000 r / min for 11 min, collect the solid, wash with ethanol 3 times, and then dry at 65 °C under vacuum for 13 h to obtain the first base material. Add 135% of cinnamaldehyde based on the mass of gelatin to the first glue solution and perform ultrasonic treatment for 7 min, then add 100% of the second glue solution based on the volume of the first glue solution, continue ultrasonic treatment for 3 min, adjust the pH to 4.0 with glacial acetic acid, then treat at 90 r / min for 65 min, cool down to 10 °C, add 0.4% of glutaraldehyde based on the volume of the first glue solution to cure for 110 min, centrifuge at 9000 r / min for 11 min, collect the solid, wash with deionized water 2 times, and after spray drying, obtain the second base material. Mix the first base material and the second base material according to a mass ratio of 1:3.3 to obtain a third base material. Then, put the third base material into ethanol according to a solid-liquid ratio of 0.17 g / mL and ultrasonically treat it for 25 min, and then dry it at 65 °C for 9 h to obtain a carrier substrate.

[0041] In this embodiment, it should be noted that the zeolite was purchased from Jiangsu Deyi Environmental Protection Technology Co., Ltd. and ground to a particle size of 10 μm.

[0042] Furthermore, the first adhesive solution was prepared by putting gelatin into deionized water at 50 °C according to a solid-liquid ratio of 0.01 g / mL and stirring for 11 min.

[0043] The second adhesive solution was prepared by putting gum arabic into deionized water according to a solid-liquid ratio of 0.01 g / mL and stirring for 11 min.

[0044] Among them, antioxidant 1076 was selected as the antioxidant.

[0045] In addition, this embodiment also provides a preparation method of the above antibacterial medical packaging film, including the following steps: Step 1: Accurately weigh high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer POE, zinc stearate and antioxidant, and put high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, polyolefin elastomer POE, zinc stearate and antioxidant into a mixing device, mix at 1700 r / min for 15 min, and then add antioxidant to it and continue to mix for 7 min; Step 2: After mixing evenly, transfer the obtained mixed material into a twin-screw extruder to extrude and granulate to obtain masterbatch; Among them, the extrusion temperature of the twin-screw extruder is divided into 4 zones. The temperature of the first zone is 162 °C, the temperature of the second zone is 172 °C, the temperature of the third zone is 182 °C, and the temperature of the fourth zone is 177 °C.

[0046] Step 3: Blow the obtained masterbatch through a blown film machine to obtain a finished product of antibacterial medical packaging film.

[0047] Among them, the die head temperature of the blown film machine is 175 °C, the air ring cooling temperature is 12 °C, the blow-up ratio is 2.7:1, and the traction speed is 17 m / min.

[0048] Example 3. The preparation method of the antibacterial medical packaging film provided in this embodiment is basically the same as that in Example 1, except that: the specific raw material composition and the specific preparation method of the antibacterial medical packaging film in this embodiment are different; the specific raw material composition and the specific preparation method of the antibacterial medical packaging film in this embodiment are as follows: An antibacterial medical packaging film is composed of the following raw materials in parts by weight: 50 parts of high-density polyethylene (HDPE), 35 parts of linear low-density polyethylene (LLDPE), 5 parts of maleic anhydride grafted polyethylene, 7 parts of antibacterial agent, 10 parts of polyolefin elastomer (POE), 3 parts of zinc stearate, and 5 parts of antioxidant.

[0049] In this embodiment, it should be noted that the high-density polyethylene (HDPE) is purchased from Ningbo Yongyang Plastic Technology Co., Ltd., the linear low-density polyethylene (LLDPE) is purchased from Guangdong Yuming New Material Technology Co., Ltd., the maleic anhydride grafted polyethylene is purchased from Dongguan Taotao Plastic Raw Materials Co., Ltd., and the polyolefin elastomer (POE) is purchased from Suzhou Suzheng Plastic Co., Ltd.

[0050] Among them, the preparation method of the antibacterial agent is as follows: Lay the carrier substrate flat with a thickness of 5 mm, spray the KH550 solution onto the carrier substrate according to a mass ratio of 0.2:1, and let it stand for 15 min. After drying, obtain the pretreated carrier substrate; Mix nanocellulose whiskers (CNW) and the pretreated carrier substrate in a ball mill under a nitrogen atmosphere according to a mass ratio of 1:5, collect the composite powder, and mix the composite powder and the pretreated silicon carbide nanowires (SiC NWs) according to a mass ratio of 5:1 to obtain the antibacterial agent.

[0051] Furthermore, the rotation speed of the ball mill is 300 - 320 r / min, the ball-to-material ratio is 10:1, and the diameter of the grinding balls is 5 mm.

[0052] Furthermore, the KH550 solution is prepared by compounding KH550 and ethanol according to a mass ratio of 1:99.

[0053] Among them, the preparation method of the pretreated silicon carbide nanowires is as follows: Put the silicon carbide nanowires into concentrated nitric acid with a volume concentration of 65% according to a solid-liquid ratio of 0.04 g / mL, and perform ultrasonic treatment for 140 min at 60 °C; Then centrifuge at 10000 r / min for 12 min, discard the supernatant, wash with deionized water until neutral, and then dry at 120 °C for 14 h to obtain the pretreated silicon carbide nanowires.

[0054] Among them, the preparation method of the carrier substrate is as follows: Put zeolite into ethanol according to a solid-liquid ratio of 0.2 g / mL, and then add 10% of methacryloyloxyethyl dimethylbenzyl ammonium chloride based on the mass of zeolite and mix well; then add 0.6% of ammonium persulfate based on the mass of zeolite, and treat at 72 °C under a nitrogen atmosphere for 7 h; centrifuge at 10000 r / min for 12 min, collect the solid, wash it with ethanol 3 times, and then dry it under vacuum at 70 °C for 14 h to obtain the first base material; Add cinnamaldehyde which is 150% of the mass of gelatin to the first glue solution and ultrasonically treat it for 10 min. Then add the second glue solution which is 100% of the volume of the first glue solution, and continue to ultrasonically treat it for 3 min. After adjusting the pH to 4.0 with glacial acetic acid, treat it for 70 min under the condition of 100 r / min. Cool down to 10 °C, add glutaraldehyde which is 0.5% of the volume of the first glue solution to it and cure for 120 min. Centrifuge for 12 min under the condition of 10,000 r / min, collect the solid, wash it 3 times with deionized water, and after spray drying, obtain the second base material; Mix the first base material and the second base material according to a mass ratio of 1:3.5 to obtain the third base material. Then put the third base material into ethanol according to a solid-liquid ratio of 0.2 g / mL and ultrasonically treat it for 30 min, and then dry it at 70 °C for 10 h to obtain the carrier substrate.

[0055] In this embodiment, it should be noted that the zeolite is purchased from Jiangsu Deyi Environmental Protection Technology Co., Ltd. and ground to a particle size of 10 μm.

[0056] Furthermore, the first glue solution is prepared by putting gelatin into deionized water at 50 °C according to a solid-liquid ratio of 0.02 g / mL and stirring for 12 min.

[0057] The second glue solution is prepared by putting gum arabic into deionized water according to a solid-liquid ratio of 0.02 g / mL and stirring for 12 min.

[0058] Among them, the antioxidant CA is selected as the antioxidant.

[0059] In addition, this embodiment also provides a preparation method of the above antibacterial medical packaging film, including the following steps: Step 1: Accurately weigh high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer POE, zinc stearate and antioxidant, and put high-density polyethylene HDPE, linear low-density polyethylene LLDPE, maleic anhydride grafted polyethylene, polyolefin elastomer POE, zinc stearate and antioxidant into the mixing equipment, mix for 10 - 20 min under the condition of 2,000 r / min, and then add the antioxidant to it and continue to mix for 10 min; Step 2: After mixing evenly, transfer the obtained mixed material into a twin-screw extruder to extrude and granulate to obtain the masterbatch; Among them, the extrusion temperature of the twin-screw extruder is divided into 4 zones. The temperature of the first zone is 165 °C, the temperature of the second zone is 175 °C, the temperature of the third zone is 185 °C, and the temperature of the fourth zone is 180 °C.

[0060] Step 3: Blow the obtained masterbatch with a blown film machine to obtain the finished antibacterial medical packaging film.

[0061] Among them, the die head temperature of the blown film machine is 175°C, the air ring cooling temperature is 15°C, the blow-up ratio is 3:1, and the traction speed is 20 m / min.

[0062] Comparative Example 1: The difference from Example 1 is that this example does not contain antibacterial agents.

[0063] Comparative Example 2: The difference from Example 1 is that this example uses an equal amount of zeolite to replace the carrier substrate.

[0064] Comparative Example 3: The difference from Example 1 is that this example uses an equal amount of carrier substrate to replace the antibacterial agent.

[0065] Performance test: The high antibacterial medical packaging film samples provided in Examples 1 to 3 and Comparative Examples 1 to 3 were respectively labeled as Examples 1 to 3 and Comparative Examples 1 to 3; and the relevant performances of the antibacterial medical packaging films provided in Examples 1 to 3 and Comparative Examples 1 to 2 were tested as follows: 1. Antibacterial test: The test method is ISO 22196-2011.

[0066] 2. Mechanical test: The test method is ASTM D638-2003 (23°C, tensile rate is 50 mm / min).

[0067] 3. Low temperature resistance test: The test method is ASTM D638-2003 (-40°C, tensile rate is 50 mm / min).

[0068] The obtained test data are recorded in Tables 1 to 3 below: Table 1 Antibacterial performance test results of each group of antibacterial medical packaging films Group Escherichia coli (%, 24 h) Staphylococcus aureus (%, 24 h) Example 1 Group 99.8 99.9 Example 2 Group 99.7 99.8 Example 3 Group 99.8 99.8 Control 1 Group No antibacterial effect No antibacterial effect Control 2 Group 67 58 Control 3 Group 82 74 Table 2 Mechanical performance test results of each group of antibacterial medical packaging films Group Tensile strength (MPa) Elongation at break (%) Example 1 Group 33 420 Example 2 Group 31 412 Example 3 Group 30 400 Control 1 Group 18 380 Control 2 Group 23 350 Control 3 Group 25 322 Table 3 Low temperature resistance performance test results of each group of antibacterial medical packaging films Group Tensile strength (MPa) Elongation at break (%) Example 1 Group 32 322 Example 2 Group 30 313 Example 3 Group 29 302 Control 1 Group 17 278 Control 2 Group 22 247 Control 3 Group 23 220 By comparing and analyzing the relevant data in Tables 1 to 3, it can be seen that the antibacterial medical packaging film prepared by the present invention not only has good antibacterial performance, but also has excellent low temperature resistance and mechanical properties, effectively ensuring its quality and quality. This shows that the antibacterial medical packaging film and its preparation method provided by the present invention have a broader market prospect and are more suitable for promotion.

[0069] In the description of this specification, the description referring to terms such as "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0070] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can well understand and utilize the present invention. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. An antibacterial medical packaging film, characterized in that, It is composed of the following raw materials in parts by weight: 40-50 parts of high-density polyethylene HDPE, 20-35 parts of linear low-density polyethylene LLDPE, 3-5 parts of maleic anhydride grafted polyethylene, 5-7 parts of antibacterial agent, 8-10 parts of polyolefin elastomer POE, 1-3 parts of zinc stearate and 2-5 parts of antioxidant; The preparation method of the antibacterial agent is as follows: Lay the carrier substrate flat with a thickness of 3-5 mm. Spray the KH550 solution onto the carrier substrate according to the mass ratio of 0.1-0.2:1, and let it stand for 10-15 min. After drying, obtain the pretreated carrier substrate; Ball-mill and mix nanocellulose whiskers and the pretreated carrier substrate according to the mass ratio of 1:4-5 under a nitrogen atmosphere, collect the composite powder, and mix the composite powder and the pretreated silicon carbide nanowires according to the mass ratio of 5:1 to obtain the antibacterial agent; The preparation method of the pretreated silicon carbide nanowires is as follows: Put the silicon carbide nanowires into concentrated nitric acid with a volume concentration of 65% according to the solid-liquid ratio of 0.02-0.04 g / mL, and perform ultrasonic treatment for 120-140 min under the condition of 55-60 °C; Then centrifuge at 8000-10000 r / min for 10-12 min, discard the supernatant, wash with deionized water until neutral, and then dry at 110-120 °C for 12-14 h to obtain the pretreated silicon carbide nanowires.

2. The antibacterial medical packaging film according to claim 1, characterized in that, The KH550 solution is prepared by compounding KH550 and ethanol according to the mass ratio of 1:96-99.

3. The antibacterial medical packaging film according to claim 1, wherein The preparation method of the carrier substrate is as follows: Put zeolite into ethanol according to the solid-liquid ratio of 0.1-0.2 g / mL, and then add 6-10% of methacryloyloxyethyl dimethylbenzyl ammonium chloride based on the mass of zeolite and mix well; then add 0.5-0.6% of ammonium persulfate based on the mass of zeolite, and treat under a nitrogen atmosphere at 70-72 °C for 6-7 h; centrifuge at 8000-10000 r / min for 10-12 min, collect the solid, wash with ethanol 2-3 times, and then dry under vacuum at 60-70 °C for 12-14 h to obtain the first base material; Add 120-150% of cinnamaldehyde based on the mass of gelatin to the first glue solution and perform ultrasonic treatment for 5-10 min, then add 100% of the second glue solution based on the volume of the first glue solution, continue ultrasonic treatment for 2-3 min, adjust the pH to 4.0 with glacial acetic acid, then treat at 80-100 r / min for 60-70 min, cool down to 10 °C, add 0.4-0.5% of glutaraldehyde based on the volume of the first glue solution and cure for 100-120 min, centrifuge at 8000-10000 r / min for 10-12 min, collect the solid, wash with deionized water 2-3 times, and after spray drying, obtain the second base material; Mix the first base material and the second base material according to the mass ratio of 1:3.2-3.5 to obtain the third base material, then put the third base material into ethanol according to the solid-liquid ratio of 0.15-0.2 g / mL and perform ultrasonic treatment for 20-30 min, and then dry at 60-70 °C for 8-10 h to obtain the carrier substrate.

4. The antibacterial medical packaging film according to claim 3, characterized in that, The first glue solution is prepared by putting gelatin into deionized water at 50°C and stirring for 10 - 12 minutes according to a solid-liquid ratio of 0.01 - 0.02 g / mL.

5. The antibacterial medical packaging film according to claim 3, characterized in that, The second glue solution is prepared by putting gum arabic into deionized water and stirring for 10 - 12 minutes according to a solid-liquid ratio of 0.01 - 0.02 g / mL.

6. The antibacterial medical packaging film according to claim 1, wherein The antioxidant is selected from any one of antioxidant 1010, antioxidant 1076, and antioxidant CA.

7. The preparation method of an antibacterial medical packaging film according to any one of claims 1 to 6, characterized in that, It includes the following steps: Step 1: Accurately weigh high-density polyethylene (HDPE), linear low-density polyethylene (LLDPE), maleic anhydride grafted polyethylene, antibacterial agent, polyolefin elastomer (POE), zinc stearate, and antioxidant, and put HDPE, LLDPE, maleic anhydride grafted polyethylene, POE, zinc stearate, and antioxidant into a mixing device, mix at 1500 - 2000 r / min for 10 - 20 minutes, then add antioxidant to it and continue to mix for 5 - 10 minutes; Step 2: After mixing evenly, transfer the obtained mixed material into a twin-screw extruder for extrusion granulation to obtain masterbatch; Step 3: Blow the obtained masterbatch by a blown film machine to obtain the finished antibacterial medical packaging film.

8. The preparation method of an antibacterial medical packaging film according to claim 7, characterized in that, In the second step, the extrusion temperature of the twin-screw extruder is divided into 4 zones. The temperature of the first zone is 160 - 165°C, the temperature of the second zone is 170 - 175°C, the temperature of the third zone is 180 - 185°C, and the temperature of the fourth zone is 175 - 180°C.