Coprophilous fungus transplantation combined preparation and method for combined treatment of intestinal diseases by combining coprophilous fungus transplantation with miR-146b

Through the method of fecal bacteria transplantation combined with miR-146b, the instability and safety of fecal bacteria transplantation in the treatment of inflammatory bowel disease was solved, and the bacterial function was accurately regulated and the infection risk was reduced, and the treatment effect was improved.

CN120285010APending Publication Date: 2025-07-11THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
0 Cites 0 Cited by

Patent Information

Application Number
CN202510475508.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-16
Publication Date
2025-07-11

AI Technical Summary

Technical Problem

The existing fecal bacteria transplantation technology has unstable efficacy in the treatment of inflammatory bowel disease, insufficient function regulation of colonization flora, safety risks, low miRNA delivery efficiency and single effect.

Method used

Fecal bacteria transplantation combined with miR-146b combined therapy, by adding chemically modified miR-146b mimic or engineered bacteria to express miR-146b to the fecal bacteria suspension, targeting the inhibition of pathogenic bacteria and promoting the growth of anti-inflammatory bacteria. Enema or oral enteric capsules ensure release in the intestinal tract, combined with colonoscopy assisted administration to accurately locate the lesion site.

Benefits of technology

The colonization rate of bacterial flora is improved, the function of precisely regulating bacterial flora is achieved, the safety risks are reduced, and the treatment effect and safety are enhanced.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention belongs to the technical field of coprophilous fungus transplantation, and particularly relates to a coprophilous fungus transplantation combined preparation and a method for combined treatment of intestinal diseases by combining coprophilous fungus transplantation with miR-146b. The coprophilous fungi transplantation combined preparation disclosed by the invention comprises coprophilous fungi and miR-146b. The invention creatively provides a coprophilous fungus transplantation and miR-146b combined therapy, and the coprophilous fungus transplantation and miR-146b combined therapy can achieve the following beneficial effects: the flora colonization rate is increased: the host intestinal microenvironment is adjusted through miR-146b, and the colonization capability of transplanted flora is enhanced; the miR-146b can inhibit the transcriptional activity of pathogenic bacteria (such as enterobacteriaceae) in a targeted manner, and can promote the functional expression of anti-inflammatory bacteria at the same time; and the safety risk is reduced: the proliferation of potential pathogenic bacteria in transplanted flora can be inhibited by miR-146b, and the adverse reaction is reduced.
Need to check novelty before this filing date? Find Prior Art