Application of L-2-HG in embryo quality evaluation, embryo quality evaluation method and application thereof
By detecting the changes in L-2-HG content in embryo culture medium and using liquid chromatography-mass spectrometry technology, the subjectivity and high cost of existing embryo quality assessment methods are solved, and high-precision, low-cost and safe embryo quality assessment is achieved, thereby improving screening efficiency and success rate.
CN120741739APending Publication Date: 2025-10-03LIANGZHU LAB
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Patent Information
- Application Number
- CN202511261575.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-05
- Publication Date
- 2025-10-03
AI Technical Summary
Technical Problem
Existing embryo quality assessment methods are highly subjective, costly, and have low sensitivity, making it difficult to achieve non-invasive and accurate embryo screening.
Method used
Embryo quality was assessed by detecting changes in L-2-HG content in the culture medium during in vitro embryo culture using liquid chromatography-mass spectrometry.
Benefits of technology
It achieves high-precision, low-cost and safe embryo quality assessment, can provide multi-dimensional evaluation indicators within 2 hours, and improves the efficiency and success rate of embryo screening.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides application of L-2-HG in embryo quality evaluation, an embryo quality evaluation method and application thereof, and relates to the technical field of biology. According to the research of the inventor, the metabolite L-2-HG generated by the embryo in the culture medium can be used as an embryo quality evaluation index, and non-invasive, accurate and reliable embryo quality evaluation can be realized according to the change of the L-2-HG in the culture medium in the culture process, so that the efficiency and success rate of embryo screening are improved.
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