Intravaginal drug delivery device based on one-way liquid guide film

Abstract

An intravaginal drug delivery device based on a one-way liquid guide film comprises a drug storage chamber, a drug storage capsule is arranged in the drug storage chamber, the intravaginal drug delivery device further comprises a supporting framework and a multi-layer film structure arranged on the outer surface of the supporting framework, and the supporting framework is of an elastic framework structure designed according to the inner contour structure of the female vagina through human engineering. The multi-layer film structure comprises a bottom film fixedly arranged on the outer surface of the supporting framework, a one-way liquid guide film arranged on the bottom film and a surface film arranged on the outer side of the one-way liquid guide film. The in-vivo unit is used for being placed in the vagina, liquid medicine in the medicine storage capsule is conveyed to the affected part in a one-way mode through the one-way liquid guide film in the multi-layer film structure, and smooth flowing of the liquid medicine is guaranteed by squeezing the medicine storage capsule through pressure. The device is reasonable in structural design, simple and convenient to use, capable of directly and continuously feeding medicine to an affected part, and capable of reducing the dosage of the medicine and the influence on the vagina environment to the maximum extent.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of gynecological drugs, and more particularly relates to a vagina-in drug device based on a one-way liquid guiding film. BACKGROUND

[0002] The female vagina is warm and humid, and a healthy vagina is in a bacterial balance state. If inflammation occurs in the vagina, the healthy bacterial flora is destroyed, which can accelerate the spread and diffusion of inflammation and also has a negative impact on healing.

[0003] In the prior art, the conventional drugs for vaginitis are generally suppositories or lotions. Whether the suppositories or the lotions, they are given to the vagina without distinction (i.e., the entire vagina is given), which not only causes overuse of the drug amount, but also further destroys the healthy bacterial flora. SUMMARY

[0004] (I) Technical problem

[0005] To sum up, how to provide a device for targeted vagina-in drug has become a problem to be solved by those skilled in the art.

[0006] (II) Technical solution

[0007] The present application provides a vagina-in drug device based on a one-way liquid guiding film, which comprises an extracorporeal unit and an intracorporeal unit.

[0008] The extracorporeal unit comprises a drug storage chamber, which comprises a drug storage chamber main body, a cabin structure is arranged in the drug storage chamber main body, a connector structure is arranged on the drug storage chamber main body corresponding to the cabin structure, a drug storage capsule connected with the connector structure is arranged in the cabin structure, and the drug storage capsule is a flexible and compressible film structure for loading liquid medicine and can provide a delivery pressure for the liquid medicine loaded therein under the action of positive pressure.

[0009] The intracorporeal unit comprises a support framework and a multilayer film structure arranged on the outer surface of the support framework, the support framework is an elastic frame structure designed by ergonomics and according to the internal profile of the female vagina, the multilayer film structure comprises a bottom film fixedly arranged on the outer surface of the support framework, a one-way liquid guiding film arranged on the bottom film, and a surface film arranged outside the one-way liquid guiding film.

[0010] The bottom membrane is a flexible and tough hydrophobic membrane, which is used to support the setting of the one-way liquid guiding membrane, the one-way liquid guiding membrane can guide liquid in one direction, which is used to guide the liquid medicine loaded in the medicine storage capsule to the vagina in one direction, the surface membrane is a flexible and hydrophobic membrane, the surface membrane is fixedly connected with the bottom membrane, and the one-way liquid guiding membrane is arranged between the bottom membrane and the surface membrane to form a one-way medicine delivery channel.

[0011] Preferably, in the one-way liquid guiding membrane based intravaginal administration device provided by the application, the support framework is curved from a titanium alloy filament, an intermediate filament for changing the profile shape of the support framework is arranged at the middle position of the support framework, the intermediate filament is arranged in the same plane as the support framework, and a raised filament is arranged on the support framework, the raised filament is smoothly arched outward relative to the plane of the support framework, and is used to improve the fitting degree of the support frame with the anterior wall of the vagina and the posterior wall of the vagina.

[0012] Preferably, in the one-way liquid guiding membrane based intravaginal administration device provided by the application, the one-way liquid guiding membrane comprises a medicine guiding area and a liquid medicine releasing area, the medicine guiding area is in a strip shape, the liquid medicine releasing area is in a circular or elliptical shape, and the medicine guiding area is used to realize one-way liquid communication between the medicine storage capsule and the liquid medicine releasing area; the administration time is changed by changing the width of the medicine guiding area and / or the internal pressure of the medicine storage chamber.

[0013] Preferably, in the one-way liquid guiding membrane based intravaginal administration device provided by the application, a liquid outlet window is arranged on the surface membrane corresponding to the liquid medicine releasing area, and a sealing film is arranged outside the surface membrane corresponding to the liquid outlet window.

[0014] Preferably, in the one-way liquid guiding membrane based intravaginal administration device provided by the application, a silicone film layer is arranged outside the support framework and the raised filament; the bottom membrane is fixedly connected with the silicone film layer.

[0015] Preferably, in the one-way liquid guiding membrane based intravaginal administration device provided by the application, the connector structure is a circular tube structure extending from the upper surface of the medicine storage chamber to the inside of the cabin structure, one end of the connector structure is connected with the medicine storage capsule, and the other end of the connector structure is flush with the upper surface of the medicine storage chamber and is sealed by arranging a sealing aluminum film.

[0016] Preferably, in the one-way liquid guiding film based intravaginal administration device provided by the present application, one end of the drug guiding area is connected with the drug liquid releasing area, the other end of the drug guiding area is provided with a piercing head, the piercing head has a channel for drug liquid flow, the end of the drug guiding area is accommodated in the channel, the bottom film and the surface film extend to the piercing head and are connected with the piercing head; the piercing head can pierce the closed aluminum film and be inserted into the joint structure.

[0017] Preferably, in the one-way liquid guiding film based intravaginal administration device provided by the present application, the one-way liquid guiding film has multiple types, and the length of the drug guiding area in each type of the one-way liquid guiding film is different.

[0018] Preferably, in the one-way liquid guiding film based intravaginal administration device provided by the present application, at least two one-way liquid guiding films are arranged in the same multi-layer film structure, at least two drug storage capsules are arranged on the drug storage chamber, and one of the drug storage capsules corresponds to each one-way liquid guiding film.

[0019] Preferably, in the one-way liquid guiding film based intravaginal administration device provided by the present application, the one-way liquid guiding film is a porous PES film, the bottom film and the surface film are PVC films or LDPE films, and the outer surface of the surface film is a smooth surface.

[0020] (III) Beneficial Effects

[0021] As can be seen from the above, the present application provides a one-way liquid guiding film based intravaginal administration device, which comprises a drug storage chamber, a cabin structure arranged in the main body of the drug storage chamber, a drug storage capsule arranged in the cabin structure, a supporting framework, and a multi-layer film structure arranged on the outer surface of the supporting framework. The supporting framework is an elastic frame structure designed by ergonomics and according to the internal profile of the female vagina. The multi-layer film structure comprises a bottom film fixedly arranged on the outer surface of the supporting framework, a one-way liquid guiding film arranged on the bottom film, and a surface film arranged on the outer side of the one-way liquid guiding film.

[0022] Through the above structural design, the one-way liquid guiding film based intravaginal administration device provided by the present application is creatively provided with an in-vivo unit and an ex-vivo unit. The ex-vivo unit is provided with a drug storage capsule, the in-vivo unit is used to be placed into the vagina to one-way transport the drug liquid in the drug storage capsule to the patient through the one-way liquid guiding film in the multi-layer film structure, and the smooth flow of the drug liquid is ensured by pressure extrusion of the drug storage capsule. The present application has reasonable structure design and is easy to use. The present application can directly and continuously administer drugs to the patient, and can minimize the drug dosage and the influence on the vaginal environment. BRIEF DESCRIPTION OF DRAWINGS

[0023] Fig. 1A schematic diagram of the structure of a supporting framework in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application;

[0024] Fig. 2 A schematic diagram of the structure of a multi-layer film in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application;

[0025] Fig. 3 A schematic diagram of the structure of a drug storage chamber in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application.

[0026] In Figs. 1 to 3 In the above description, the correspondence between the component names and the reference numerals is as follows:

[0027] Drug storage chamber main body 1, cabin structure 2, joint structure 3, drug storage capsule 4, supporting framework 5, intermediate filament 6, raised filament 7, bottom film 8, one-way liquid guiding film 9, drug liquid release area 91, drug guiding area 92, and protruding head 10. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solutions and advantages of the present application clearer, the following will further describe the embodiments of the present application in conjunction with the drawings.

[0029] In addition, in the description of the present application, the orientations or positional relationships indicated by the terms "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and do not require the present application to be constructed and operated in a particular orientation, and therefore should not be understood as a limitation on the present application. The terms "connected", "connected" used in the present application should be understood broadly, for example, can be fixed connection, can also be detachable connection; can be directly connected, can also be indirectly connected through intermediate components. For those skilled in the art, the specific meanings of the above terms can be understood according to the specific circumstances.

[0030] Please refer to Figs. 1 to 3 In which, Fig. 1 A schematic diagram of the structure of a supporting framework in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application; Fig. 2 A schematic diagram of the structure of a multi-layer film in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application; Fig. 3 A schematic diagram of the structure of a drug storage chamber in an intravaginal administration device based on a one-way liquid guiding film according to an embodiment of the present application.

[0031] The application provides an intravaginal administration device based on a one-way liquid guiding film, which is mainly composed of two parts, namely an in-vivo unit and an out-vivo unit.

[0032] For the in-vitro unit, its core structure is a drug storage chamber capable of bearing pressure, which is made of medical plastic. The specific manufacturing material and wall thickness of the drug storage chamber are designed according to the designed pressurized drug delivery parameters. The pressure-bearing capacity of the drug storage chamber is at least twice the highest design pressure of the pressurized drug delivery, which is the design standard. For example, in the present application, the design pressure of the pressurized drug delivery is 0.08-0.12 MPa, and the pressure-bearing capacity of the drug storage chamber is at least 0.24 MPa. The drug storage chamber is designed as a flat curved surface structure according to ergonomics (smooth curved surface structure with both ends curved upward in the front view, and shuttle-shaped structure in the top view but with both ends as circular arc ends). Since the drug storage chamber is made of hard plastic, in the wearing condition, this design (flat curved surface structure) can be more fitted to the user's private parts, improving the comfort (larger area of skin contact, without pressing the skin) and privacy (closer to the shape of the natural state of the private parts) of the present application. If the drug storage chamber is used alone, the bottom surface of the drug storage chamber is provided with an adhesive layer, and the surface of the adhesive layer is provided with a release film. Before use, tear off the release film, and the drug storage chamber can be stuck to the underpants through the adhesive layer, thereby improving the stability of the drug storage chamber during use. The upper side of the drug storage chamber is provided with a silica gel layer or a cotton layer (consistent with the skin-friendly material provided on the surface of the traditional sanitary napkin), and when a silica gel layer is used, a plurality of groove structures are provided on the surface of the silica gel layer to improve the air permeability of the silica gel layer. The purpose of providing the silica gel layer or the cotton layer is to improve the comfort when the drug storage chamber contacts the human skin. The drug storage chamber is designed as a double-layer structure, the outer layer is the drug storage chamber body 1, which is a hard structure made of medical plastic, and at least one independent cabin structure 2 (generally designed as three) is arranged in the drug storage chamber body 1. A drug storage capsule 4 is arranged in the cabin structure 2, which is made of flexible film and stores a drug liquid for treating vaginitis or a probiotic nutrient liquid beneficial to the vaginal environment. A joint structure 3 extending inward is arranged on the drug storage chamber body 1 corresponding to each cabin structure 2, and the drug storage capsule 4 is fixedly arranged on the joint structure 3. The joint structure 3 is open at one end connected with the drug storage capsule 4, and the other end (also designed as an open structure) of the joint structure 3 is flush with the surface of the drug storage chamber body 1. For the other end of the joint structure 3, a preferred design scheme of the present application is to provide a puncturable closed aluminum film for closing the opening of the other end of the joint structure 3, and then to open the opening by piercing the closed aluminum film with a sharp structure.

[0033] The manufacturing process of the medicine storage chamber is briefly described as follows: first, the medicine storage chamber body 1 is divided into an upper body and a lower body, the lower body is provided with a plurality of groove structures, the upper body and the joint structure 3 are designed in an integrated manner, and the upper body and the lower body are integrally formed by the same medical plastic; second, the medicine storage capsule 4 is arranged at one end of the joint structure 3 by using a heat sealing process (the medicine storage capsule 4 is sleeved on the joint structure 3, and then the edges of the medicine storage capsule 4 in contact with the joint structure 3 are sealed and connected by heating), and the medicine storage capsule 4 is filled with liquid medicine, and the liquid medicine naturally expands the medicine storage capsule 4; third, an aluminum film plastic package (which needs to have pressure bearing capacity) is arranged on the upper body corresponding to the other end opening of the joint structure 3, so that the medicine storage capsule 4 forms a closed flexible medicine storage structure; fourth, the lower body and the upper body are butted and fixedly connected (heat sealing or glue fixing can be used), and after the lower body and the upper body are fixedly connected, the groove structure of the lower body forms a cabin structure 2, and each cabin structure 2 is provided with one medicine storage capsule 4; fifth, nitrogen gas is filled into the inside of the medicine storage chamber body 1 to pressurize, and the pressurizing pressure is preferably 0.12 MPa.

[0034] In the present application, the medicine storage chamber body 1 and the medicine storage capsule 4 are designed in a transparent structure, which facilitates observation of the medicine administration situation (the remaining amount of the liquid medicine). In the present application, the liquid storage capacity of each medicine storage capsule 4 is about 5 ml, and due to various reasons, the liquid loss is set to be 1.5 ml during use, so the actual liquid supply amount of each medicine storage capsule 4 is 3.5 ml, therefore, the concentration of the effective component in the liquid medicine should be based on the medicine amount of 3.5 ml.

[0035] In order to improve the comfort of the present application during administration, the present application can set a pad structure based on the structure of the above-mentioned medicine storage chamber, the pad structure is basically the same as the traditional sanitary napkin structure, and can be outsourced for production and manufacturing. An installation groove is arranged in the middle position of the pad structure according to the structure of the medicine storage chamber, the medicine storage chamber is arranged in the installation groove, the upper surface of the medicine storage chamber is flush with the upper surface of the pad structure, and the lower surface can be exposed outside the pad. The medicine storage chamber and the pad structure are fixedly connected, for example, an extension of 2-3 mm is arranged around the medicine storage chamber, the extension is arranged in the pad and fixedly connected by glue.

[0036] For the in-vivo unit, the specific structure is as follows: the in-vivo unit comprises a flexible support skeleton 5, which is designed according to ergonomics, and the overall contour shape is close to the shape presented by the female vagina in a natural state, but slightly larger (more than 10%-20%). The support skeleton 5 is made of titanium alloy filaments, and the overall shape of the support skeleton 5 is close to a water droplet, which is close to the transverse cross-sectional shape of the vagina. The support skeleton 5 has a certain tension, and the support skeleton 5 is made of a complete titanium alloy filament, the two ends of which are brought together, and the other segments naturally "expand" to form a shape close to a water droplet. The present application can also set an intermediate filament 6 at the "expansion" position to change the overall contour shape of the support skeleton 5, so that it is more close to the transverse cross-sectional shape of the female vagina. The support skeleton 5 is a planar structure, and a raised filament 7 is also provided on the support skeleton 5, which forms a smooth convex structure relative to the plane of the support skeleton 5, so as to be more fitted to the anterior wall of the vagina. The raised filament 7 can be provided on both sides of the support skeleton 5, so as to be more fitted to the anterior wall of the vagina and the posterior wall of the vagina. Specifically, the overall length of the support skeleton 5 is between 7 cm and 9 cm, the maximum width of the support skeleton 5 is between 2 cm and 4 cm, and the raised height of the raised filament 7 is between 2 mm and 4 mm. A silicone film layer with a thickness of 1 mm to 2 mm is provided on the support skeleton 5, the intermediate filament 6 and the raised filament 7, and the two ends of the titanium alloy filaments constituting the support skeleton 5 are fixedly connected through the silicone film layer after being kept 1 cm to 1.5 cm wide. The entire support skeleton 5 is an elastically deformable skeleton. The diameter of the support skeleton 5, the intermediate filament 6 and the raised filament 7 is between 1 mm and 2 mm. A multi-film layer structure is provided on the outer side of the entire support skeleton 5 (including the raised filament 7). Specifically, the multi-film layer structure comprises a bottom film 8, a one-way liquid guiding film 9 provided on the outer side of the bottom film 8, and a surface film provided on the outer side of the one-way liquid guiding film 9, and the surface film is provided with a liquid outlet window. A sealing film is provided on the outer side of the surface film and corresponds to the liquid outlet window, and the sealing film can be torn off before use.In the present application, the bottom film 8 is used as the base, and the unidirectional liquid guiding film 9 is arranged on the bottom film 8 and supported by the bottom film 8. The unidirectional liquid guiding film 9 has a drug liquid releasing area 91, which is circular or elliptical in structure and has a diameter ranging from 1.0 cm to 1.5 cm. The unidirectional liquid guiding film 9 also has a drug guiding area 92, which is long strip-shaped in structure and has a width ranging from 0.2 cm to 0.4 cm. One end of the drug guiding area 92 is connected to the drug liquid releasing area 91, and the other end of the drug guiding area 92 is provided with a pricking head 10 (the length of the pricking head 10 is consistent with the depth of the joint structure 3 or slightly larger than 2-3 mm). One end of the pricking head 10 is pointed, and the pricking head 10 can penetrate the closed aluminum film arranged on the joint structure 3 and be inserted into the joint structure 3 through the pointed structure. The pricking head 10 has a drug liquid flow channel, and the other end of the drug guiding area 92 is accommodated in the drug liquid flow channel. After the pricking head 10 penetrates into the joint structure 3, the drug liquid in the drug liquid capsule flows into the drug liquid flow channel under the action of pressure and is absorbed by the drug guiding area 92. The drug guiding area 92 is unidirectional, and the drug liquid can diffuse along the drug guiding area 92 to the drug liquid releasing area 91 for release under the action of pressure. In the present application, the unidirectional liquid guiding film 9 has multiple types, and the lengths of the drug guiding area 92 in different types of unidirectional liquid guiding film 9 are different, so that targeted drug delivery can be performed on different positions of the vagina. Generally, the length of the drug guiding area 92 ranges from 1 cm to 2 cm, 2 cm to 3 cm, 3 cm to 4 cm, 4 cm to 5 cm, or 5 cm to 6 cm. Multiple unidirectional liquid guiding films 9 can be arranged on the same bottom film 8, and gaps are provided between the multiple unidirectional liquid guiding films 9 (especially, the drug liquid releasing areas 91 of the unidirectional liquid guiding films 9 do not contact each other), so that different drug liquids can be provided to different areas. The cover film covers the entire bottom film 8 and is fixedly connected to the bottom film 8, so that a drug liquid flow channel can be formed between the cover film and the bottom film 8 through the unidirectional liquid guiding film 9. The edges of the bottom film 8 and the cover film are fixedly connected and fixedly connected to the silica gel film layer arranged on the support framework 5, and the entire multi-film layer structure is supported and expanded by the support framework 5 and the raised filaments 7. Specifically, the unidirectional liquid guiding film 9 is a porous PES film, the bottom film 8 and the cover film can be PVC films or LDPE films, and the outer surface of the cover film is smooth, which makes it easier to push the in-vivo unit into the vagina.

[0037] The manufacturing method of the in-vivo unit is briefly described as follows: first, the shape of the whole multi-layer film structure is designed according to the structure of the supporting framework 5; second, the bottom film 8, the one-way liquid guiding film 9 and the surface film (with a window and a closed film) are manufactured respectively; third, the bottom film 8 or the surface film is glued (the gluing part is the contact part of the bottom film 8 and the surface film, and the part corresponding to the one-way liquid guiding film 9 is not glued), then the bottom film 8, the one-way liquid guiding film 9 and the surface film are laminated and pressed tightly, so that the contact part of the bottom film 8 and the surface film forms airtight connection structure by gluing; fourth, the drug guiding area 92 of the one-way liquid guiding film 9 forms a "small tail" extending out of the bottom film 8 and the surface film and is inserted into the protruding structure, and the bottom film 8 and the surface film are also provided with an extension part wrapped on the outer side of the protruding structure. Through the above steps, a complete in-vivo unit can be formed. In use, the protruding structure pierces the closed aluminum film, then the in-vivo unit is pushed into the vagina so that the drug storage chamber is attached to the human skin, and then the underpants are put on. Through the design of the width of the one-way liquid guiding film 9 and the pressure in the drug storage chamber, the drug delivery time can be limited, for example, two hours, three hours or four hours. The wider the width of the drug guiding area 92 and the greater the pressure in the drug storage chamber, the faster the drug delivery and the shorter the drug delivery time.

[0038] From the common general knowledge, the present application can be realized by other embodiments which do not depart from the spirit or essential characteristics thereof. Therefore, the above disclosed embodiments, in all aspects, are only illustrative and not restrictive. All changes within the scope of the present application or within the equivalent scope of the present application are intended to be embraced by the present application.

Claims

1. An intravaginal drug delivery device based on a one-way liquid guide membrane, characterized in that: Including in vitro and in vivo units: The in vitro unit includes a drug storage chamber, which includes a drug storage chamber body, a cabin structure provided in the drug storage chamber body, a joint structure provided on the drug storage chamber body corresponding to the cabin structure, a drug storage capsule connected to the joint structure provided in the cabin structure, the drug storage capsule being a flexible and compressible membrane structure for loading a drug solution and providing a delivery pressure for the drug solution loaded therein under the action of positive pressure; The in-vivo unit includes a support frame and a multi-layer membrane structure provided on the outer surface of the support frame. The support frame is an elastic frame structure designed based on ergonomics and the internal contour of the female vagina. The multi-layer membrane structure includes a base membrane fixedly provided on the outer surface of the support frame, a one-way liquid-conducting membrane provided on the base membrane, and a surface membrane provided on the outer side of the one-way liquid-conducting membrane. The base membrane is a flexible and tough hydrophobic membrane, which is used to provide support for the setting of the one-way liquid guide membrane. The one-way liquid guide membrane can guide liquid in a one-way manner and is used to guide the liquid medicine loaded in the medicine storage capsule into the vagina in a one-way manner. The surface membrane is a flexible hydrophobic membrane, which is fixedly connected to the base membrane, and the one-way liquid guide membrane is arranged between the base membrane and the surface membrane to form a one-way drug delivery channel.

2. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 1, characterized in that: The support frame is formed by bending a titanium alloy filament, and an intermediate filament for changing the contour shape of the support frame is arranged in the middle position of the support frame. The intermediate filament is arranged in the same plane as the support frame, and a raised filament is arranged on the support frame. The raised filament is smoothly arched outward relative to the plane where the support frame is located, and is used to improve the fit between the support frame and the anterior and posterior walls of the vagina.

3. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 2, characterized in that: The one-way liquid guide membrane includes a drug guide area and a drug release area. The drug guide area is a long strip structure, and the drug release area is a circular or elliptical structure. The drug guide area is used to achieve one-way liquid guide communication between the drug storage capsule and the drug release area. The drug administration time is changed by changing the width of the drug guiding area and / or the internal pressure of the drug storage chamber.

4. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 3, characterized in that: A liquid outlet window is provided on the surface membrane corresponding to the liquid release area, and a sealing membrane is provided on the outer side of the surface membrane corresponding to the liquid outlet window.

5. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 4, characterized in that: A silicone film layer is provided on the outer sides of the support frame and the raised filaments; The base film is fixedly connected to the silicone film layer.

6. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 5, characterized in that: The joint structure is a circular tube structure extending from the upper surface of the medicine storage chamber to the interior of the cabin structure. One end of the joint structure is connected to the medicine storage capsule, and the other end of the joint structure is flush with the upper surface of the medicine storage chamber and is closed by providing a closed aluminum film.

7. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 6, characterized in that: One end of the drug-conducting area is connected to the drug-liquid releasing area, and the other end of the drug-conducting area is provided with a protruding head, wherein the protruding head has a channel for the circulation of the drug liquid, and the end of the drug-conducting area is accommodated in the channel, and the bottom film and the surface film extend to the protruding head and are connected to the protruding head; The piercing head can pierce the closed aluminum film and be inserted into the joint structure.

8. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 3, characterized in that: The one-way liquid guide film has multiple types, and the lengths of the drug guide areas in each type of the one-way liquid guide film are different.

9. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 8, characterized in that: At least two one-way liquid-guiding films are provided in the same multi-layer film structure, at least two drug storage capsules are provided on the drug storage chamber, and each one-way liquid-guiding film is provided with a corresponding drug storage capsule.

10. The intravaginal drug delivery device based on a one-way liquid guide membrane according to claim 8, characterized in that: The one-way liquid guide membrane is a porous PES membrane, the bottom membrane and the surface membrane are PVC membrane or LDPE membrane, and the outer surface of the surface membrane is a smooth surface.

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