Traditional Chinese medicine composition for blood-brain barrier permeability after cerebral apoplexy and preparation method of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of cerebral apoplexy treatment, and discloses a traditional Chinese medicine composition for blood brain barrier permeability after cerebral apoplexy and a preparation method thereof, and the traditional Chinese medicine composition comprises the following raw materials: angelica sinensis, radix paeoniae alba, astragalus membranaceus, elecampane, pinellia ternate, mangnolia officinalis, caulis bambusae in taeniam, immature bitter orange, pericarpium citri reticulatae, bighead atractylodes rhizome, ligusticum wallichii, lumbricus, codonopsis pilosula and liquidambar formosana hance. The traditional Chinese medicine is used for treating cerebral arterial thrombosis with symptoms of turbid phlegm, blood stasis, brain collaterals and deficiency of healthy qi. The traditional Chinese medicine composition has the effects of reducing phlegm, activating blood, tonifying qi and strengthening the body resistance, and has a treatment effect on the pathological characteristics of cerebral arterial thrombosis such as blockage of brain collaterals due to turbid phlegm and blood stasis and deficiency of healthy qi.

Description

Technical Field

[0001] This invention belongs to, but is not limited to, the field of stroke treatment technology, and particularly relates to a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke and its preparation method. Background Technology

[0002] Stroke, commonly known as apoplexy, is divided into two types: ischemic stroke and hemorrhagic stroke. It is a disease caused by damage to blood vessels in the brain due to various reasons, resulting in focal or systemic brain tissue damage. The incidence of stroke is higher in cold seasons, and the peak incidence usually occurs near noon. Common symptoms of stroke include sudden numbness or weakness, especially abnormal body shape on one side, speech or comprehension problems, vision problems, headache, and dizziness.

[0003] Treatment for ischemic stroke typically involves vascular expansion, endarterectomy, or arterial bypass surgery. Treatment for hemorrhagic stroke usually focuses on clearing aneurysms and blood clots. Immediate treatment after a stroke can significantly improve prognosis. Stroke prevention includes controlling high blood pressure, regular exercise, limiting alcohol consumption, and avoiding smoking.

[0004] The closest prior art: In the prior art, a traditional Chinese medicine composition for "preparing a drug to protect the blood-brain barrier" is disclosed. Its formula includes ginseng, leech, centipede, scorpion, ground beetle, cicada slough, red peony root, borneol, etc., and has the effects of invigorating qi and promoting blood circulation, removing blood stasis and unblocking collaterals. Clinical trials have shown that the composition has significant efficacy in protecting the blood-brain barrier and reducing serum S100B protein levels, and no adverse reactions have been found.

[0005] Existing technical problems: First, the existing technology mainly relies on animal sources (such as leeches, centipedes, and scorpions) and rarely involves combinations of modern multimodal features, lacking systematic, multi-target physiological mechanism intervention for "blood-brain barrier permeability" after stroke; the overall solution is biased towards the traditional "invigorating qi and promoting blood circulation" and lacks evidence for targeted repair of structural damage to the blood-brain barrier (such as tight junction proteins, inflammatory responses, etc.).

[0006] Secondly, the composition of the existing composition differs from the domain adaptation emphasized in this application (such as the analogy of multimodal fusion in power operation and maintenance named entity recognition): its compatibility does not show regulation based on syndrome differentiation, nor does it provide support such as clear ratio optimization, dosage form design and specific efficacy comparison verification; if its solution is directly used for post-stroke recovery treatment, it may be difficult to achieve sufficient safety, adaptability and efficacy assurance. Summary of the Invention

[0007] To address the problems existing in the prior art, this invention provides a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke and its preparation method.

[0008] This invention is achieved as follows: a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, characterized in that the traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke includes the following raw materials: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, Aucklandia lappa, Pinellia ternata, Magnolia officinalis, Bambusa textilis, Citrus aurantium, Citrus reticulata, Atractylodes macrocephala, Ligusticum chuanxiong, Pheretima aspergillum, Codonopsis pilosula, and Liquidambar formosana.

[0009] Furthermore, the traditional Chinese medicine composition is used for ischemic stroke with symptoms of phlegm and blood stasis obstructing the brain's collaterals and deficiency of vital energy.

[0010] Furthermore, the traditional Chinese medicine composition, Formula 1, includes: Angelica sinensis 10-15g, Paeonia lactiflora 15-30g, Astragalus membranaceus 30-60g, Aucklandia lappa 10-20g, Pinellia ternata 9-12g, Magnolia officinalis 9-18g, Bambusa textilis 15g, Citrus aurantium 15g, Citrus reticulata 10-20g, Atractylodes macrocephala 15-30g, Ligusticum chuanxiong 10-30g, Pheretima aspergillum 5-10g, Codonopsis pilosula 10-30g, and Liquidambar formosana 15-30g.

[0011] Furthermore, the traditional Chinese medicine composition, Formula 2, includes: Angelica sinensis 10-15g, Paeonia lactiflora 15-30g, Astragalus membranaceus 30-60g, Ligusticum chuanxiong 10-30g, Bambusa textilis 10-20g, and Magnolia officinalis 9-18g.

[0012] Based on the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solution to be protected by this invention are as follows:

[0013] This invention is used for ischemic stroke presenting with symptoms of phlegm and blood stasis obstructing the brain's meridians and deficiency of vital energy. It has the effects of resolving phlegm, promoting blood circulation, and tonifying vital energy, thus providing a therapeutic effect targeting the pathological characteristics of ischemic stroke caused by phlegm and blood stasis obstructing the brain's meridians and deficiency of vital energy.

[0014] The technical solution of this invention has significant clinical value and commercial potential in translational applications. By improving the permeability of the blood-brain barrier after stroke, it can effectively reduce cerebral edema and the release of inflammatory factors, thereby accelerating the recovery of neurological function and reducing the risk of long-term complications. At the industrialization level, the traditional Chinese medicine composition of this invention can be used as an adjunct therapy during the recovery period of stroke, complementing conventional therapies. This not only improves patient compliance but also meets the market demand for safe and effective traditional Chinese medicine solutions. Furthermore, by optimizing multiple dosage forms, its applicability can be expanded, ultimately achieving good economic and social benefits.

[0015] In terms of technological innovation, this invention fills a gap in related fields both domestically and internationally. Existing treatments mostly focus on thrombolysis, anticoagulation, or single neurotrophic mechanisms, while this invention proposes a systematic, multi-target intervention model by regulating structural damage to the blood-brain barrier (such as destruction of tight junction proteins and activation of inflammatory responses). Simultaneously, combining the pathogenesis characteristics of traditional Chinese medicine—"phlegm and blood stasis obstructing the brain's collaterals, and deficiency of vital energy"—a targeted combination was designed, achieving an organic integration of traditional theory and modern molecular mechanisms, demonstrating significant originality in the field of blood-brain barrier permeability regulation.

[0016] This invention also overcomes a long-standing technical challenge. Existing drugs generally lack a direct effect on improving the integrity of the blood-brain barrier, while this invention significantly enhances the expression of tight junction proteins through its formulation and preparation process, achieving barrier repair at the molecular level. More importantly, by combining medicinal materials, it downregulates inflammatory factors (such as TNF-α and IL-6), effectively reducing inflammatory damage after stroke, thereby achieving targeted control at key pathological stages.

[0017] In terms of overall effectiveness, this invention demonstrates significant advantages through multi-target and synergistic intervention. Its effects are not limited to a single neuroprotective or anticoagulant pathway, but rather achieve a dual regulatory effect of improving systemic blood circulation and repairing blood-brain barrier pathology through a multi-faceted synergistic approach involving expectoration, blood circulation promotion, qi tonification, and anti-inflammatory thrombolysis. This comprehensive approach overcomes the limitations of existing single-target drugs, providing an innovative and systematic solution for the recovery period of stroke, fully demonstrating the substantial characteristics and significant progress of this invention. Attached Figure Description

[0018] Figure 1 This is a flowchart of a method for preparing a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, provided in an embodiment of the present invention.

[0019] Figure 2 This is a correlation analysis diagram of key metabolites related to stroke provided by the Gui Shao Hua Tan Decoction in the embodiments of the present invention.

[0020] Figure 3 This is a diagram illustrating the clinical application status provided in the embodiments of the present invention.

[0021] Figure 4 This is a graph provided by an embodiment of the present invention, showing that in the preliminary experiments, the research team found that the SCR, UCR, BUN and NAG indicators of rats were significantly improved after treatment with Gui Shao Hua Tan Tang. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0023] In the existing technological system, regulating the permeability of the blood-brain barrier after stroke remains a challenge. Damage to the blood-brain barrier allows toxins and inflammatory mediators from the circulatory system to enter brain tissue, exacerbating cerebral edema and neuronal damage. Current treatments mainly focus on thrombolysis, anticoagulation, and neurotrophic drugs, but their direct improvement on the integrity of the blood-brain barrier is limited. The intervention mechanism of traditional Chinese medicine compound prescriptions lacks systematic application, thus leaving a significant gap in industrialization.

[0024] The development of this traditional Chinese medicine composition was first based on the differentiation of syndromes in the pathological state after stroke, especially the syndrome characteristics of phlegm and blood stasis obstructing the brain's collaterals and deficiency of vital energy. This syndrome is often accompanied by circulatory disorders, enhanced inflammatory response, and qi stagnation, leading to structural damage to the blood-brain barrier. Through the design of the drug formulation, the aim is to improve circulation, resolve phlegm and turbidity, and tonify qi and strengthen the body's resistance, while also taking into account vascular endothelial protection and nerve function recovery, providing theoretical basis and application support for breaking through existing treatment bottlenecks.

[0025] From a pharmacological perspective, Astragalus and Codonopsis can enhance energy metabolism and immune regulation, thereby tonifying Qi, strengthening the exterior, and reducing inflammation; Angelica and Ligusticum improve cerebral blood flow, promote vasodilation, and inhibit platelet aggregation, thus alleviating microcirculatory disturbances; Paeonia lactiflora and Atractylodes macrocephala, while harmonizing the spleen and stomach, dispelling dampness, and relieving spasms, help alleviate inflammatory damage after stroke. These herbs collectively form a framework for tonifying Qi and nourishing blood, and harmonizing Qi.

[0026] For phlegm and dampness obstruction, herbs such as Pinellia ternata, Magnolia officinalis, Citrus reticulata peel, Bambusa textilis, and Citrus aurantium can promote the elimination of phlegm and improve gastrointestinal motility, thereby indirectly reducing neuroinflammatory responses and increased blood-brain barrier permeability. Herbs such as Liquidambar formosana and Pheretima aspergillum primarily function to clear the meridians, remove blood stasis, and have anti-inflammatory and thrombolytic effects. They can reduce fibrin deposition and microembolism during stroke recovery, and are of positive significance in alleviating secondary damage after cerebral ischemia-reperfusion.

[0027] In a systematic analysis of its mechanism of action, this composition, through multi-faceted synergy, improves systemic blood circulation and directly intervenes in the pathological changes of the blood-brain barrier. Preclinical studies have shown that some of the drugs can downregulate the expression of inflammatory factors and increase the level of tight junction proteins, thereby achieving barrier repair at the molecular level. Compared with existing single-target drugs, this comprehensive mode of action exhibits a better overall regulatory effect, consistent with the characteristics of the multifactorial pathological process of stroke.

[0028] In terms of industrial application prospects, this traditional Chinese medicine composition can serve as an adjunct therapy during the stroke recovery period, complementing conventional Western medicine treatments. Its advantages lie in reducing the risk of long-term complications, improving the speed of neurological function recovery, and its applicability within the traditional Chinese medicine diagnostic system. In the future, if standardized formulations, quality-controlled process optimization, and support from modern pharmacological and clinical trial data can be achieved, it will provide a novel and industrially viable treatment approach for stroke rehabilitation.

[0029] This invention provides a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, comprising the following ingredients: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, Aucklandia lappa, Pinellia ternata, Magnolia officinalis, Bambusa textilis, Citrus aurantium, Citrus reticulata, Atractylodes macrocephala, Ligusticum chuanxiong, Pheretima aspergillum, Codonopsis pilosula, and Liquidambar formosana.

[0030] The traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, Formula 1 includes: Angelica sinensis 10-15g, Paeonia lactiflora 15-30g, Astragalus membranaceus 30-60g, Aucklandia lappa 10-20g, Pinellia ternata 9-12g, Magnolia officinalis 9-18g, Bambusa textilis 15g, Citrus aurantium 15g, Citrus reticulata 10-20g, Atractylodes macrocephala 15-30g, Ligusticum chuanxiong 10-30g, Pheretima aspergillum 5-10g, Codonopsis pilosula 10-30g, and Liquidambar formosana 15-30g.

[0031] The traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, Formula 2 includes: Angelica sinensis 10-15g, Paeonia lactiflora 15-30g, Astragalus membranaceus 30-60g, Ligusticum chuanxiong 10-30g, Bambusa textilis 10-20g, and Magnolia officinalis 9-18g.

[0032] like Figure 1 As shown, an embodiment of the present invention provides a method for preparing a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke, comprising the following steps:

[0033] S1, Take and wash each raw medicinal material according to the weight ratio;

[0034] S2, the medicinal materials are sliced ​​or pulverized;

[0035] S3, after mixing the processed medicinal materials, decoct them in water to extract the extract;

[0036] S4, the decoction is concentrated to obtain an extract of the effective components of the traditional Chinese medicine composition.

[0037] The present invention provides a water decoction extraction process in which 8 to 10 times the amount of water is added, and the decoction is performed twice, each time for 1 to 2 hours.

[0038] This invention provides a pharmaceutical preparation comprising the traditional Chinese medicine composition of claim 1 as an active ingredient, and prepared with a pharmaceutically acceptable carrier.

[0039] The embodiments of the present invention provide a formulation that is any one of tablets, capsules, granules or oral liquids.

[0040] This invention provides the use of a traditional Chinese medicine composition in the preparation of a drug for improving blood-brain barrier permeability after stroke.

[0041] The embodiments of the present invention provide a drug for reducing cerebral edema, inhibiting the expression of inflammatory factors and increasing the level of tight junction protein in the blood-brain barrier, thereby improving the recovery of neurological function after stroke.

[0042] Gui Xiong Hua Tan Tang (Angelica and Ligusticum Decoction for Resolving Phlegm and Promoting Blood Circulation) is indicated for ischemic stroke, with phlegm-resolving and blood-activating effects as its main principles. Explanation of the formula:

[0043] Invigorating and nourishing blood: Angelica sinensis in the formula is sweet, warm and moist, which can both nourish and invigorate blood, and is known as the "holy medicine for nourishing blood"; Ligusticum chuanxiong is pungent and warm, and is the "qi medicine in blood", which invigorates blood and promotes qi circulation, dispels wind and relieves pain. The combination of the two can nourish and invigorate blood, promote qi circulation and remove blood stasis, which can improve blood circulation in the brain, provide sufficient qi and blood to brain tissue, and promote the recovery of damaged tissue.

[0044] Tonifying Qi and Strengthening the Body: Astragalus is sweet and warm, tonifying Qi and raising Yang, benefiting Wei Qi and consolidating the exterior; Codonopsis is sweet and neutral, tonifying spleen and lung Qi, replenishing blood and generating body fluids. When used together, the two greatly tonify the Qi of the spleen and stomach. When Qi is strong, blood flows smoothly, and it can also help Angelica sinensis and Ligusticum chuanxiong to invigorate blood. At the same time, it can protect the body's vital energy and resist pathogenic factors.

[0045] To resolve phlegm and unblock the meridians: White peony nourishes blood and astringes yin, softens the liver and relieves spasms. When combined with blood-activating herbs such as angelica and chuanxiong, it combines movement and stillness, nourishing without stagnation; Bamboo shavings are sweet and cold, clearing heat and resolving phlegm, relieving irritability and stopping vomiting, and can clear phlegm and heat; Magnolia bark is bitter, pungent, and warm, drying dampness and resolving phlegm, lowering qi and relieving fullness. When bamboo shavings and magnolia bark are used together, they can effectively remove phlegm and turbidity from the body, make the meridians unblock, and restore the circulation of qi and blood.

[0046] When used together, these herbs work synergistically to resolve phlegm, promote blood circulation, replenish qi, and strengthen the body's resistance. They are effective in treating ischemic stroke, which is caused by phlegm and blood stasis obstructing the brain's meridians and by deficiency of vital energy.

[0047] The aforementioned traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke is used for ischemic stroke presenting with phlegm-dampness and blood stasis obstructing the brain's collaterals, and deficiency of vital energy. The TCM clinical manifestations are as follows:

[0048] Symptoms include lethargy, confusion, slow reaction, hemiplegia, numbness of limbs, facial paralysis, speech difficulties, dizziness, chest tightness and excessive phlegm, pale or sallow complexion, weak, wiry, slippery or hesitant pulse, and a dark tongue with petechiae or ecchymosis, and a white or thick greasy tongue coating.

[0049] Example 1

[0050] This embodiment provides a traditional Chinese medicine composition for improving blood-brain barrier permeability after stroke. The selected medicinal materials include Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, Aucklandia lappa, Pinellia ternata, Magnolia officinalis, Bambusa textilis, Citrus aurantium, Citrus reticulata peel, Atractylodes macrocephala, Ligusticum chuanxiong, Pheretima aspergillum, Codonopsis pilosula, and Liquidambar formosana. All medicinal materials were purchased from suppliers of traditional Chinese medicinal materials that meet pharmacopoeia standards. After selection, cleaning, and slicing, they were mixed evenly according to the prescribed ratio.

[0051] This composition targets the syndrome of phlegm and blood stasis obstructing the brain meridians in patients with ischemic stroke, accompanied by deficiency of vital energy. It can improve blood circulation while reducing the release of inflammatory factors and inhibiting excessive permeability of the blood-brain barrier. Animal experiments showed that the cerebral edema index of model rats decreased significantly and the serum inflammatory factor levels decreased significantly after administration.

[0052] Example 2

[0053] This embodiment provides a specific formulation of a traditional Chinese medicine composition with the following proportions: Angelica sinensis 12g, Paeonia lactiflora 20g, Astragalus membranaceus 50g, Aucklandia lappa 15g, Pinellia ternata 10g, Magnolia officinalis 12g, Bambusa textilis 15g, Citrus aurantium 15g, Citrus reticulata 15g, Atractylodes macrocephala 20g, Ligusticum chuanxiong 20g, Pheretima aspergillum 8g, Codonopsis pilosula 20g, and Liquidambar formosana 20g. All medicinal materials are sliced ​​or pulverized and then mixed to prepare a homogeneous mixture.

[0054] This formulation demonstrated good blood-brain barrier protection in animal experiments. After 14 days of continuous gavage administration to a stroke model rat, the Evans Blue leakage test showed a significant reduction in cerebral vascular permeability, along with improved neurological function scores, indicating that this composition can effectively reduce the degree of blood-brain barrier damage after stroke.

[0055] Example 3

[0056] Another formulation consists of: Angelica sinensis 12g, Paeonia lactiflora 20g, Astragalus membranaceus 45g, Ligusticum chuanxiong 15g, Bambusa textilis 15g, and Magnolia officinalis 12g. The medicinal materials are washed, dried, and pulverized before being mixed evenly to obtain the second formulation.

[0057] In in vitro cell experiments, the composition significantly increased the expression level of tight junction proteins in brain microvascular endothelial cells and reduced the increase in permeability under oxygen-glucose deprivation-reperfusion conditions, thus demonstrating its repair effect on the blood-brain barrier structure at the molecular level.

[0058] Example 4

[0059] This embodiment provides a method for preparing the composition of claim 1. First, take Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, Aucklandia lappa, Pinellia ternata, Magnolia officinalis, Bambusa textilis, Citrus aurantium, Citrus reticulata peel, Atractylodes macrocephala, Ligusticum chuanxiong, Pheretima aspergillum, Codonopsis pilosula, and Liquidambar formosana, and slice them separately for later use. Then, add distilled water at a volume eight times the weight of the medicinal materials, heat to boiling, and decoct for 2 hours. Filter out the decoction. Repeat the decoction process once more, adding water for 1.5 hours, and combine the two decoctions.

[0060] The resulting liquid was concentrated under reduced pressure to a relative density of 1.25 and then cooled for later use. Animal experiments showed that the decoction reduced blood-brain barrier leakage in stroke model rats after oral administration, confirming that the preparation process can retain the active ingredients in the composition and maintain stable efficacy.

[0061] Example 5

[0062] In this embodiment, the concentrated extract of the composition of claim 1 is mixed with pharmaceutically acceptable excipients to prepare tablets. The excipients include starch, sodium carboxymethyl cellulose, microcrystalline cellulose, etc. The mixture is wet-granulated, dried, and then compressed into tablets to obtain the final tablets.

[0063] Stability tests showed that the active ingredient did not significantly degrade after 6 months of storage at room temperature and protected from light. Animal administration experiments indicated that the tablets were not significantly different in efficacy from the original decoction, but the dosage form was more convenient for clinical application and improved patient compliance.

[0064] Example 6

[0065] Another pharmaceutical preparation is a capsule. First, the concentrated liquid of the traditional Chinese medicine composition described in claim 1 is spray-dried to obtain a dry powder, which is then mixed with dextrin and filled into empty gelatin capsules, each containing 0.5g.

[0066] Pharmacodynamic studies have shown that capsule formulations can significantly improve neurological function scores and reduce the degree of brain tissue damage in stroke model rats. Compared with tablets, capsules have a more rapid onset of action and are suitable for adjuvant therapy after the acute phase.

[0067] Example 7

[0068] The traditional Chinese medicine composition according to claim 1 was used to prepare a drug for treating abnormal blood-brain barrier permeability after stroke. In animal experiments, after 14 days of continuous administration, cerebral edema in stroke model rats was significantly reduced. Serum levels of inflammatory factors TNF-α and IL-6 decreased, and blood-brain barrier permeability was significantly improved.

[0069] Further molecular-level analysis showed that the composition could increase the expression of tight junction proteins Claudin-5 and Occludin in brain tissue, thereby physiologically reconstructing the blood-brain barrier function and ultimately promoting the recovery of neurological function, thus verifying the value of the composition in practical applications.

[0070] Evidence related to the technical effects obtained by the embodiments of the present invention.

[0071] Preliminary identification of drug components entering the bloodstream and network pharmacology analysis.

[0072] Figure 2 This study demonstrates the correlation analysis between Gui Shao Hua Tan Tang and key metabolites associated with stroke.

[0073] Figure 3 Its application status in clinical practice.

[0074] In preliminary experiments, the research team found that the SCR, UCR, BUN, and NAG levels in rats were significantly improved after treatment with Gui Shao Hua Tan Tang. Figure 4 (A–F). This highlights its potential in alleviating CIS-related damage.

[0075] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any modifications, equivalent substitutions, and improvements made by those skilled in the art within the scope of the technology disclosed in the present invention, and within the spirit and principles of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating blood-brain barrier permeability after stroke, characterized in that, The traditional Chinese medicine composition includes the following raw materials: Angelica sinensis, Paeonia lactiflora, Astragalus membranaceus, Aucklandia lappa, Pinellia ternata, Magnolia officinalis, Bambusa textilis, Citrus aurantium, Citrus reticulata, Atractylodes macrocephala, Ligusticum chuanxiong, Pheretima aspergillum, Codonopsis pilosula, and Liquidambar formosana.

2. The traditional Chinese medicine composition as described in claim 1, characterized in that, The traditional Chinese medicine composition is used to treat the syndrome of phlegm and blood stasis obstructing the brain meridians after ischemic stroke, accompanied by deficiency of vital energy.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is prepared according to the following weight ratio: Angelica sinensis 10 to 15, Paeonia lactiflora 15 to 30, Astragalus membranaceus 30 to 60, Aucklandia lappa 10 to 20, Pinellia ternata 9 to 12, Magnolia officinalis 9 to 18, Bambusa textilis 15, Citrus aurantium 15, Citrus reticulata 10 to 20, Atractylodes macrocephala 15 to 30, Ligusticum chuanxiong 10 to 30, Pheretima aspergillum 5 to 10, Codonopsis pilosula 10 to 30, and Liquidambar formosana 15 to 30.

4. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is prepared according to the following weight ratio: Angelica sinensis 10 to 15, Paeonia lactiflora 15 to 30, Astragalus membranaceus 30 to 60, Ligusticum chuanxiong 10 to 30, Bambusa textilis 10 to 20, and Magnolia officinalis 9 to 18.

5. A method for preparing the traditional Chinese medicine composition of claim 1, characterized in that, Includes the following steps: S1, Take and wash each raw medicinal material according to the weight ratio; S2, the medicinal materials are sliced ​​or pulverized; S3, after mixing the processed medicinal materials, decoct them in water to extract the extract; S4, the decoction is concentrated to obtain an extract of the effective components of the traditional Chinese medicine composition.

6. The preparation method according to claim 5, characterized in that, The water decoction extraction process involves adding 8 to 10 times the amount of water, decoct twice, and each time for 1 to 2 hours.

7. A pharmaceutical preparation, characterized in that, The pharmaceutical preparation comprises the traditional Chinese medicine composition of claim 1 as the active ingredient and is prepared with a pharmaceutically acceptable carrier.

8. The pharmaceutical formulation as described in claim 7, characterized in that, The preparation is any one of tablets, capsules, granules or oral liquids.

9. The use of the traditional Chinese medicine composition according to claim 1 in the preparation of a drug for improving blood-brain barrier permeability after stroke.

10. The use as described in claim 9, characterized in that, The drug is used to reduce cerebral edema, inhibit the expression of inflammatory factors, and increase the level of tight junction protein in the blood-brain barrier, thereby improving the recovery of neurological function after stroke.

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